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Articles 75511 - 75540 of 1449633
Full-Text Articles in Entire DC Network
Wine Production In The Byzantine Winepresses Of Southern Israel: Insights From A Statistical Analysis, Matan Chocron, Oren Ackermann, Ilan Stavi, Boaz Zissu
Wine Production In The Byzantine Winepresses Of Southern Israel: Insights From A Statistical Analysis, Matan Chocron, Oren Ackermann, Ilan Stavi, Boaz Zissu
'Atiqot
This paper focuses on various technological aspects of Byzantine winepresses. The Byzantine period presents a unique point in time when the increased demand for wine from the Southern Levant is attested by the introduction of new elements in the architecture and design of the winepress. Whereas past studies have stressed the importance of the introduction of the screw-press, it is shown here that this is but one of numerous features that helped increase the yield. Other elements, such as the addition of a second collecting vat and the integration of fermentation cells contributed significantly to local wine production in the …
Iron Age Ii And Persian-Period Wine Production In Southern Samaria: New Data From Archaeological Surveys, Aharon Tavger
Iron Age Ii And Persian-Period Wine Production In Southern Samaria: New Data From Archaeological Surveys, Aharon Tavger
'Atiqot
New evidence for Iron Age II and Persian-Period wine production in southern Samaria, including many winepresses and bell-shaped winery pits, has recently come to light, expanding our knowledge and revising some of our understandings concerning this phenomenon. While it was widely accepted that industrial wine production during these periods was confined to central Judah, in Jerusalem’s environs, it is now clear that wine was also produced throughout the southern Samaria region, particularly on the desert fringes. Some of these wine-production sites seemingly functioned already during Iron Age IIB, under Northern Kingdom control, while some of the sites also operated under …
Identifying The (Royal) Winepresses In The “Valley Of The King”, Benyamin Storchan, Nathan Ben-Ari, Neria Sapir, Oded Lipschits
Identifying The (Royal) Winepresses In The “Valley Of The King”, Benyamin Storchan, Nathan Ben-Ari, Neria Sapir, Oded Lipschits
'Atiqot
This paper presents four Iron Age winepresses discovered at ‘Emeq Lavan, Rogem Gannim and Mordot Arnona in Jerusalem. The winepresses located along ‘Emeq Refa’im share a uniform industrial plan featuring three treading surfaces, settling vats and a central collection chamber. The installations date to the late eighth–seventh centuries BCE, when the subjugation of Judah to Assyria created a need for a centralized royal economy. The newly identified winepresses attest to the high degree of standardization of wine production in the region. We suggest that the location and implementation of a standardized plan indicate that these installations were part of a …
Front Matter & Editorial, The Editorial Board
Front Matter & Editorial, The Editorial Board
'Atiqot
Wine consumption is an ongoing social act practiced on domestic, religious and state level, and as such, it defines social status, cultural affiliation and identity. The current volume presents a varied range of studies that broadly consider wine, wine production and trade in the Southern Levant.
Powerpoint: Charges Of Forgery: Roger Williams And The Narragansett Deed To Providence, Heather Marie Rockwell, Jeroen Van Den Hurk Ph.D., William Leeman, Liza Tietjen
Powerpoint: Charges Of Forgery: Roger Williams And The Narragansett Deed To Providence, Heather Marie Rockwell, Jeroen Van Den Hurk Ph.D., William Leeman, Liza Tietjen
Rare Book Salon Fall 2024: Charges of Forgery
In the Fall 2024 Rare Book Salon, Salve’s archivist and faculty with expertise in the fields of archaeology, cultural and historic preservation, and history engage in a multidisciplinary discussion spanning Indigenous histories and land evidence. In this 1896 paper from Salve Special Collections on the authenticity of the 1638 deed to Moshassuck, which would become the site of Providence, George Paine uses legal evidence and primary sources to examine the document signed by Sachems Canonicus and Miantonomi that conveyed the land rights to the English colonizer.
Exploring The Role Of Tissue-Resident T Cells In Neurotropic Viral Infections And Opioid-Induced Immune Disorders During Exposure And Withdrawal, Shenjian Ai
Arts & Sciences Electronic Theses and Dissertations
Tissue-resident T cells play a crucial role in the immune response to neurotropic viral infections and opioid-induced immune disorders. Understanding the roles of tissue-resident T cells in these contexts is essential for developing therapeutic strategies to mitigate their detrimental effects while enhancing their protective functions. The chemokine receptor CXCR6 and its ligand CXCL16 are critical in maintaining the population of tissue-resident T cells in the CNS. CXCR6 is expressed on CD8 T cells that persist in the CNS after recovery from West Nile virus infection. Research has shown that CXCL16, produced by microglia and other myeloid cells, binds to CXCR6 …
The Chanticleer, 2024-11-14, Coastal Carolina University
The Chanticleer, 2024-11-14, Coastal Carolina University
The Chanticleer Student Newspaper
The editorially independent student produced weekly newspaper of Coastal Carolina University.
The Indiana Statesman, November 14, 2024, Indiana State University
The Indiana Statesman, November 14, 2024, Indiana State University
Student Newspaper
Veteran’s Day Parade; Indiana State Theater presents: Hamlet
Curricular Changes Proposed For 2025-2027 Morris Catalog Division Of Humanities, Division Of Education, And Clean-Up Of All Divisions, Curriculum Committee
Curricular Changes Proposed For 2025-2027 Morris Catalog Division Of Humanities, Division Of Education, And Clean-Up Of All Divisions, Curriculum Committee
Curriculum Committee Reports
No abstract provided.
The Power Of The Written Word: An Exploration Of Writing As Craft And Pedagogy, Kristen Charlesworth
The Power Of The Written Word: An Exploration Of Writing As Craft And Pedagogy, Kristen Charlesworth
Master of Arts in English Plan II Graduate Projects
This portfolio is an exploration of writing, both as a crafted process and a subject of pedagogy. It includes three pieces of vastly different genres, which have one overlapping theoretical notion: autonomy is a key ingredient to successful writing at any level. Student success, creative writing, and scholarly research are all enhanced when the writer is given opportunities to guide their own process. The selected works of this portfolio serve as examples of how student autonomy is not only possible in the classroom, but of the overwhelmingly positive effect it has on the writing process, student engagement, and ultimately, academic …
Navigating Challenges In Higher Education: Narratives Of Undocumented And Daca Recipient Latine Students In Arkansas, Christian Miguel Canizales
Navigating Challenges In Higher Education: Narratives Of Undocumented And Daca Recipient Latine Students In Arkansas, Christian Miguel Canizales
Student Theses and Dissertations
The current study investigated the challenges that undocumented and DACA recipient Latine students in Arkansas face and how they navigate their challenges. Furthermore, the study analyzed the ways in which the challenges and navigation methods influenced the student’s sense of belonging and academic performance. The current study provides support to higher education administration who have previously lacked empirical research to aid in guiding their services provide to Latine DACA and undocumented students. Higher education administrations now use the current study as a foundation for enhancing their services to not only Latine students but other minoritized populations as well. Biographical narrative …
The Integration Of African American History Into State History Curriculum Standards: Examining The Commonwealth Of Virginia, Roxanne Souma
The Integration Of African American History Into State History Curriculum Standards: Examining The Commonwealth Of Virginia, Roxanne Souma
Student Theses and Dissertations
This qualitative case study sought to analyze and describe both the quantity and quality of African American history curriculum integration into Virginia's U.S. History curriculum standards at three points in time (2008 standards, 2015 standards, and revised 2020 standards) in the three U.S. history courses (USI, 5th, USII, 6th, VUS, 11th). Regarding quality, the study measured African American history integration in the three identified U.S. History courses in the three standards revision years according to Banks' (1994) Four Levels of Multicultural Integration, as defined and discussed in the Conceptual Framework. The study results indicated Virginia's U.S. history courses integrate African …
Multitiered Systems Of Support And The Achievement Gap In The Washington, Dc, Metropolitan Mid-Atlantic Region: An Analysis Of Teacher Perceptions Of Effectiveness, Demarco Ray Brooks
Multitiered Systems Of Support And The Achievement Gap In The Washington, Dc, Metropolitan Mid-Atlantic Region: An Analysis Of Teacher Perceptions Of Effectiveness, Demarco Ray Brooks
Student Theses and Dissertations
Efforts to bridge educational achievement gaps and address inequities remain a central challenge across the United States. The multitiered system of supports has emerged as a prominent intervention framework with which to equip educators for this task. Given its growing adoption across school districts, a deeper understanding of teacher perspectives on the effectiveness of the framework is vital to efforts by educational stakeholders, leaders, and officials to eliminate achievement gaps. This study specifically involved exploration of teacher perceptions regarding the impact of the framework on marginalized students’ academic achievement and its use to close achievement gaps. Analysis of interviews and …
All Things Marian: Devotion And Spirituality To Mary In Music, University Of Dayton. International Marian Research Institute, Michele Foley, Richard E. Lenar
All Things Marian: Devotion And Spirituality To Mary In Music, University Of Dayton. International Marian Research Institute, Michele Foley, Richard E. Lenar
Podcast: All Things Marian
Transcript is available using the "Download" button.
The Comment, November 14, 2024, Bridgewater State University
The Comment, November 14, 2024, Bridgewater State University
The Comment
No abstract provided.
Conference Report: Review Of Clinical Implementation Of Advanced Quantitative Imaging Techniques For Personalized Radiotherapy, Yevgeniy Vinogradskiy, Houda Bahig, Nicholas Bucknell, Jeffrey Buchsbaum, Hui-Kuo George Shu
Conference Report: Review Of Clinical Implementation Of Advanced Quantitative Imaging Techniques For Personalized Radiotherapy, Yevgeniy Vinogradskiy, Houda Bahig, Nicholas Bucknell, Jeffrey Buchsbaum, Hui-Kuo George Shu
Department of Radiation Oncology Faculty Papers
The topic of quantitative imaging in radiation therapy was presented as a "Masterclass" at the 2023 annual meeting of the American Society of Radiation Oncology (ASTRO). Dual-energy computed tomography (CT) and single-positron computed tomography were reviewed in detail as the first portion of the meeting session, with data showing utility in many aspects of radiation oncology including treatment planning and dose response. Positron emission tomography/CT scans evaluating the functional volume of lung tissue so as to provide optimal avoidance of healthy lungs were presented second. Advanced brain imaging was then discussed in the context of different forms of magnetic resonance …
Perspectives On The Value Proposition Of K-8 Non-Orthodox Jewish Day Schools In Toronto, Amy Goldsweig
Perspectives On The Value Proposition Of K-8 Non-Orthodox Jewish Day Schools In Toronto, Amy Goldsweig
Educational Studies Dissertations
The purpose of this study was to better understand the value proposition of K-8 nonOrthodox Jewish day school education in Toronto by examining enrolment information and reasons for attrition to non-parochial private schools. These findings led to recommendations to help improve the value proposition. Future research was also suggested.
Northern Iowa Symphony Orchestra & Uni Jazz Band One, November 14, 2024 [Program], University Of Northern Iowa. School Of Music.
Northern Iowa Symphony Orchestra & Uni Jazz Band One, November 14, 2024 [Program], University Of Northern Iowa. School Of Music.
Music Recital Programs
Program of a music recital given by faculty, students, or guest artists from the School of Music at the University of Northern Iowa.
A Novel Machine Learning Model To Predict Revision Acl Reconstruction Failure In The Mars Cohort, Kinjal Vasavada, Vrinda Vasavada, Jay Moran, Sai Devana, Changhee Lee, Sharon L. Hame, Laith M. Jazrawi, Orrin H. Sherman, Laura J. Huston, Amanda K. Haas, Christina R. Allen, Daniel E. Cooper, Thomas M. Deberardino, Kurt P. Spindler, Michael J. Stuart, Annunziato Ned Amendola, Christopher C. Annunziata, Robert A. Arciero, Bernard R. Bach, Champ L. Baker, Arthur R. Bartolozzi, Keith M. Baumgarten, Jeffrey H. Berg, Geoffrey A. Bernas, Stephen F. Brockmeier, Robert H. Brophy, Charles A. Bush-Joseph, J. Brad Butler V, James L. Carey, James E. Carpenter, Brian J. Cole, Jonathan M. Cooper, Charles L. Cox, R. Alexander Creighton, Tal S. David, Warren R. Dunn, David C. Flanigan, Robert W. Frederick, Theodore J. Ganley, Charles J. Gatt, Steven R. Gecha, James Robert Giffin, Jo A. Hannafin, Norman Lindsay Harris, Keith S. Hechtman, Elliott B. Hershman, Rudolf G. Hoellrich, David C. Johnson, Timothy S. Johnson, Morgan H. Jones, Christopher C. Kaeding, Ganesh V. Kamath, Thomas E. Klootwyk, Bruce A. Levy, C. Benjamin Ma, G. Peter Maiers, Robert G. Marx, Matthew J. Matava, Gregory M. Mathien, David R. Mcallister, Eric C. Mccarty, Robert G. Mccormack, Bruce S. Miller, Carl W. Nissen, Daniel F. O'Neill, Brett D. Owens, Richard D. Parker, Mark L. Purnell, Arun J. Ramappa, Michael A. Rauh, Arthur C. Rettig, Jon K. Sekiya, Kevin G. Shea, James R. Slauterbeck, Matthew V. Smith, Jeffrey T. Spang, Steven J. Svoboda, Timothy N. Taft, Joachim J. Tenuta, Edwin M. Tingstad, Armando F. Vidal, Darius G. Viskontas, Richard A. White, James S. Williams, Michelle L. Wolcott, Brian R. Wolf, Rick W. Wright, James J. York
A Novel Machine Learning Model To Predict Revision Acl Reconstruction Failure In The Mars Cohort, Kinjal Vasavada, Vrinda Vasavada, Jay Moran, Sai Devana, Changhee Lee, Sharon L. Hame, Laith M. Jazrawi, Orrin H. Sherman, Laura J. Huston, Amanda K. Haas, Christina R. Allen, Daniel E. Cooper, Thomas M. Deberardino, Kurt P. Spindler, Michael J. Stuart, Annunziato Ned Amendola, Christopher C. Annunziata, Robert A. Arciero, Bernard R. Bach, Champ L. Baker, Arthur R. Bartolozzi, Keith M. Baumgarten, Jeffrey H. Berg, Geoffrey A. Bernas, Stephen F. Brockmeier, Robert H. Brophy, Charles A. Bush-Joseph, J. Brad Butler V, James L. Carey, James E. Carpenter, Brian J. Cole, Jonathan M. Cooper, Charles L. Cox, R. Alexander Creighton, Tal S. David, Warren R. Dunn, David C. Flanigan, Robert W. Frederick, Theodore J. Ganley, Charles J. Gatt, Steven R. Gecha, James Robert Giffin, Jo A. Hannafin, Norman Lindsay Harris, Keith S. Hechtman, Elliott B. Hershman, Rudolf G. Hoellrich, David C. Johnson, Timothy S. Johnson, Morgan H. Jones, Christopher C. Kaeding, Ganesh V. Kamath, Thomas E. Klootwyk, Bruce A. Levy, C. Benjamin Ma, G. Peter Maiers, Robert G. Marx, Matthew J. Matava, Gregory M. Mathien, David R. Mcallister, Eric C. Mccarty, Robert G. Mccormack, Bruce S. Miller, Carl W. Nissen, Daniel F. O'Neill, Brett D. Owens, Richard D. Parker, Mark L. Purnell, Arun J. Ramappa, Michael A. Rauh, Arthur C. Rettig, Jon K. Sekiya, Kevin G. Shea, James R. Slauterbeck, Matthew V. Smith, Jeffrey T. Spang, Steven J. Svoboda, Timothy N. Taft, Joachim J. Tenuta, Edwin M. Tingstad, Armando F. Vidal, Darius G. Viskontas, Richard A. White, James S. Williams, Michelle L. Wolcott, Brian R. Wolf, Rick W. Wright, James J. York
Rothman Institute Papers
BACKGROUND: As machine learning becomes increasingly utilized in orthopaedic clinical research, the application of machine learning methodology to cohort data from the Multicenter ACL Revision Study (MARS) presents a valuable opportunity to translate data into patient-specific insights.
PURPOSE: To apply novel machine learning methodology to MARS cohort data to determine a predictive model of revision anterior cruciate ligament reconstruction (rACLR) graft failure and features most predictive of failure.
STUDY DESIGN: Cohort study; Level of evidence, 3.
METHODS: The authors prospectively recruited patients undergoing rACLR from the MARS cohort and obtained preoperative radiographs, surgeon-reported intraoperative findings, and 2- and 6-year follow-up …
The Relationship Between Mychart Use And Patient Socio-Demographic Factors Of Age, Race, And Insurance Status., Omomhengbe Imhansi-Jacob
The Relationship Between Mychart Use And Patient Socio-Demographic Factors Of Age, Race, And Insurance Status., Omomhengbe Imhansi-Jacob
Walden Dissertations and Doctoral Studies
The specific research problem addressed through this study was that health disparities continue to rise due to inconsistent use of MyChart. The purpose of this quantitative correlational study was to examine the relationship, if any, between the dependent variables of patient MyChart use and activation and the independent variables of age, race, and type of healthcare coverage at a general hospital with over 300 beds located in the Northeastern region of the United States and not been previously used for research. The conceptual framework guiding this research was Antonio and Petrovskaya’s electronic health equity framework (eHEF), which arises from the …
Service-Learning Reflection: Advent Health Hospital, Paola Urena
Service-Learning Reflection: Advent Health Hospital, Paola Urena
UN SDG Open Pedagogy Faculty Fellowship: Renewable Assignments
No abstract provided.
Evidence That Crispr-Cas9 Y537s-Mutant Expressing Breast Cancer Cells Activate Yes-Associated Protein 1 To Driving The Conversion Of Normal Fibroblasts Into Cancer-Associated Fibroblasts, Luca Gelsomino, Amanda Caruso, Emine Tasan, Adele Elisabetta Leonetti, Rocco Malivindi, Giuseppina Daniela Naimo, Francesca Giordano, Salvatore Panza, Guowei Gu, Benedetta Perrone, Cinzia Giordano, Loredana Mauro, Bruno Nardo, Gianfranco Filippelli, Daniela Bonofiglio, Ines Barone, Suzanne A W Fuqua, Stefania Catalano, Sebastiano Andò
Evidence That Crispr-Cas9 Y537s-Mutant Expressing Breast Cancer Cells Activate Yes-Associated Protein 1 To Driving The Conversion Of Normal Fibroblasts Into Cancer-Associated Fibroblasts, Luca Gelsomino, Amanda Caruso, Emine Tasan, Adele Elisabetta Leonetti, Rocco Malivindi, Giuseppina Daniela Naimo, Francesca Giordano, Salvatore Panza, Guowei Gu, Benedetta Perrone, Cinzia Giordano, Loredana Mauro, Bruno Nardo, Gianfranco Filippelli, Daniela Bonofiglio, Ines Barone, Suzanne A W Fuqua, Stefania Catalano, Sebastiano Andò
Faculty, Staff and Students Publications
BACKGROUND: Endocrine therapy (ET) has improved the clinical outcomes of Estrogen receptor alpha-positive (ERɑ +) breast cancer (BC) patients, even though resistance to ET remains a clinical issue. Mutations in the hormone-binding domain of ERɑ represent an acquired intrinsic mechanism of ET resistance. However, the latter also depends on the multiple functional interactions between BC cells and the tumor microenvironment (TME). Here, we investigated how the most common Y537S-ERɑ mutation may influence the behavior of fibroblasts, the most prominent component of the TME.
METHODS: We conducted coculture experiments with normal human foreskin fibroblasts BJ1-hTERT (NFs), cancer-associated fibroblasts (CAFs), isolated from …
November 2024 Graduate Council Minutes, University Of Nebraska At Kearney Graduate Council
November 2024 Graduate Council Minutes, University Of Nebraska At Kearney Graduate Council
Graduate Council Minutes
No abstract provided.
Addressing Statistical Challenges In The Analysis Of Proteomics Data With Extremely Small Sample Size: A Simulation Study, Kyung Hyun Lee, Shervin Assassi, Chandra Mohan, Claudia Pedroza
Addressing Statistical Challenges In The Analysis Of Proteomics Data With Extremely Small Sample Size: A Simulation Study, Kyung Hyun Lee, Shervin Assassi, Chandra Mohan, Claudia Pedroza
Faculty, Staff and Student Publications
Background: One of the most promising approaches for early and more precise disease prediction and diagnosis is through the inclusion of proteomics data augmented with clinical data. Clinical proteomics data is often characterized by its high dimensionality and extremely limited sample size, posing a significant challenge when employing machine learning techniques for extracting only the most relevant information. Although there is a wide array of statistical techniques and numerous analysis pipelines employed in proteomics data analysis, it is unclear which of these methods produce the most efficient, reproducible, and clinically meaningful results.
Results: In this study, we compared 9 unique …
Exploring The Role Of Tissue-Resident T Cells In Neurotropic Viral Infections And Opioid-Induced Immune Disorders During Exposure And Withdrawal, Shenjian Ai
Arts & Sciences Graduate Student Theses and Dissertations
Tissue-resident T cells play a crucial role in the immune response to neurotropic viral infections and opioid-induced immune disorders. Understanding the roles of tissue-resident T cells in these contexts is essential for developing therapeutic strategies to mitigate their detrimental effects while enhancing their protective functions. The chemokine receptor CXCR6 and its ligand CXCL16 are critical in maintaining the population of tissue-resident T cells in the CNS. CXCR6 is expressed on CD8 T cells that persist in the CNS after recovery from West Nile virus infection. Research has shown that CXCL16, produced by microglia and other myeloid cells, binds to CXCR6 …
African American Male Overidentification In Special Education Services: Teacher Perspectives On The Referral Process, Amanda Gray
African American Male Overidentification In Special Education Services: Teacher Perspectives On The Referral Process, Amanda Gray
Student Theses and Dissertations
This qualitative narrative study explored the perceptions of public-school general education teachers on the training they received for referring students to special education. Two key aspects of this were investigated: (1) navigating the special education referral process, and (2) using individualized interventions that are effective with African American male students. The problem addressed in this study is the overidentification of African American male students in special education. This causes concern in the educational community, as students misidentified often suffer unintended consequences such as segregated learning environments, low expectations, and fewer post-secondary opportunities. Using social inequality theory as a theoretical framework, …
Antibiogram Pattern Of Enterococcus Species Among Urinary Tract-Infected Patients Visiting Tertiary Care Hospital In Karnataka, India, Sujatha Bhat, Dushan Uvindu Gunawardana, Delisha Kaur Boparai, Tharinya Kasundie Bamunusinghe
Antibiogram Pattern Of Enterococcus Species Among Urinary Tract-Infected Patients Visiting Tertiary Care Hospital In Karnataka, India, Sujatha Bhat, Dushan Uvindu Gunawardana, Delisha Kaur Boparai, Tharinya Kasundie Bamunusinghe
Open Access archive
Background: During the past several decades, enterococci are emerging as an important cause of healthcare-associated infections. They have developed resistance to various antimicrobials previously used for the treatment of urinary tract infections (UTIs). This study was aimed to determine the prevalence of Enterococcus species among urinary tract-infected patients in a tertiary care hospital, in Karnataka, India. Material and Methods: We have analyzed 4341 culture-positive urine samples received by microbiology laboratory during the year 2021. The bacterial identification was done by matrix-assisted laser desorption ionization-time of flight mass spectrometry. The antibiotic sensitivity was tested by automated VITEK-2® COMPACT (bioMérieux) system. Results: …
Exploring Community Adaptation To Public Safety Power Shutoff Events: Findings From Two Case Studies Of Unincorporated Mountain Communities In Southern California, Ramiro M. Brown
Master's Theses
As aging electrical infrastructure in the US continues to succumb to unyielding weather patterns brought on by climate change, there is an urgency among Investor-Owned Utilities (IOUs) to reduce the likelihood of their equipment sparking a wildfire. Public Safety Power Shutoffs (PSPS) – the intentional de-energization of the electrical grid on high fire weather danger days – have become a staple in IOU Wildfire Mitigation Plans (WMPs) since 2018 as one way to avoid wildfire ignitions via electrical infrastructure. One criticism of PSPS events is that they create their own hazard by cutting off power to thousands – sometimes millions-of …
Enhancing Cross-Cultural Communication In Low-Resource Language Conversational Agents, Hardi V. Trivedi
Enhancing Cross-Cultural Communication In Low-Resource Language Conversational Agents, Hardi V. Trivedi
Master's Theses
Recent advancements in natural language processing (NLP) and large language models (LLMs) have facilitated the development of systems capable of generating human-like responses across a wide range of tasks. However, the majority of research has focused predominantly on English, overlooking the vast linguistic diversity globally. For true global inclusivity, extending research to other languages is crucial, particularly as it can significantly benefit various sectors such as business, healthcare, government, and education. A major challenge in this expansion is the scarcity of digital data available and the limited number of pre-trained models for low-resource languages. Our research specifically addresses these challenges …