Digital Commons Network^™

Evaluating Human Plasma Biomakers For Alzheimer's Disease; Phosphorylated-Tau 217, Phosphorylated-Tau 181, And Glial Fibrillary Acidic Protein, Mason Jonah, Mayarae N. Mugosa, Bella Hou, Emma-Nikole Krilchev, Zhengshi Yang, Dietmar Cordes, Aaron Ritter, Jefferson W. Kinney

Undergraduate Research Symposium Posters

Alzheimer’s Disease (AD) is a progressive neurodegenerative disease that is primarily identifiable by amyloid-beta (Aβ) neuronal plaques, neurofibrillary tangles (NFT) that form as aggregates of hyperphosphorylated tau (ptau) proteins clump together, and the presence of neuroinflammation; all of which are otherwise known as the hallmarks of AD pathology. Recent emerging research has discovered striking similarities between AD and diabetes mellitus pathology, illustrating how insulin deficiency and insulin resistance–both of which result in the chronic hyperglycemic state seen in the diabetic–are involved in an increase in the phosphorylation of tau. This leads to and intensifies the formation of intracellular NFTs serving …

Association Between Polygenic Scores For Brain Structure And Alzheimer's Disease, Eunjae Lee, Faria Tavacoli, Tingwei Liu, Brittany Diaz Ruiz, Hayley Ho, Alice Lee, Jingchun Chen

Undergraduate Research Symposium Posters

Alzheimer’s disease (AD) is a progressive neurodegenerative condition and the most common type of dementia. Research has shown that volumetric changes in subcortical brain structures, which make up roughly 25% of the brain's total volume and affect many physiological functions. This research project aims to investigate the genetic association between brain structures and AD. GWAS data of eight different brain structures (ICV, accumbens, amygdala, caudate, hippocampus, pallidum, putamen, and thalamus) were used to create polygenic scores (PGSs) in a discovery (cases/controls = 2,651/2,768) and replication dataset (cases/controls = 553/644). We utilized PRSice-2 software to generate PGSs and assess genetic correlations …

The Sacred Duty Of The Christian Storyteller: The Rediscovery Of Divine Creative Heritage And Its Function In The Public Square, Trinity Wood

Senior Honors Theses

This thesis assesses the specific value of the storytelling medium and evaluates how one’s artistic duty coexists with their spiritual responsibility as a Bible-believing Christian. Storytelling has a proven power to evoke change within society and within the hearts of its members, and creativity is an innate characteristic we share with the original Divine Creator. Creativity is our birthright and our inheritance from God the Father, as beings made in His Image. The secular entertainment industry often appears as foreign enemy territory to the Christian creative – in most recent years, faith-based content has garnered a poor reputation for itself …

Ev Charging At Multifamily Properties: Moving Beyond Barriers, Whit Jamieson, Anna Guida, Connor Herman

PSU Transportation Seminars

Transportation is the top contributor of greenhouse gas emissions in the US and light-duty vehicles are the #1 contributor to transportation emissions. Mass adoption of electric vehicles (EVs) is key in the fight toward a more sustainable future, but there are several factors that have delayed our transition to EVs.

EV charging at home is the most convenient and cost-effective charging option for EV drivers, but people living in multifamily housing face serious barriers to accessing home charging. During this session, we will explore why EV charging at multifamily housing is critical to mass adoption of EVs, barriers to charging …

Factors Related To Racial Trauma Distress Among Bipoc College Students, Miguel Castano, Richard Chang, Giezel Guevarra

Undergraduate Research Symposium Posters

Racial trauma distress is when post-traumatic stress disorder symptoms occur due to repeated and cumulative experiences of racism and can negatively impacted Black, Indigenous, and people of color (BIPOC). Consensus in research findings strongly suggest that BIPOC students are more likely to experience racism on university campuses than non-BIPOC students. To mitigate some of these negative outcomes, existing research has shown that psychological safety, resilience, and intraminority solidarity are protective factors for BIPOC students experiencing race-related distress. However, little is known about the frequency of racial trauma distress among BIPOC college students and how these variables may protect against racial …

"We Are All About Equality": D/Deaf Inclusivity In Little Wimmin, Ruth Ann Leber

Theses and Dissertations

Figs in Wigs integration of a British Sign Language interpreter in their performance of Little Wimmin is a compelling example of inclusive theatre for D/deaf audiences. By examining the works of foundational D/deaf studies scholars Neil Glickman and Paddy Ladd alongside the works of contemporary D/deaf scholars such as Tom Humphries, Carol Padden, and Michael Richardson we can gain valuable insight into the evolution of the D/deaf culture and identity. This paper will refer to diversity scholar Susanne Ricee when defining the difference between accommodation, access, accessibility, and inclusivity. It will explore the current advantages and limitations of D/deaf accommodations …

Maternal Morbidity Associated With Early Preterm Birth In Low-Risk Singleton Pregnancies, Moti Gulersen, Erez Lenchner, Alisha Goyal, Amos Grunebaum, Frank A. Chervenak, Eran Bornstein

Department of Obstetrics and Gynecology Faculty Papers

Background/Objectives: While neonatal morbidities associated with early preterm birth are known, the risks of maternal morbidities in these births remain unclear. Thus, we set out to assess the risk of maternal morbidities associated with early preterm births. Methods: Retrospective cohort study utilizing the United States (US) Natality Live Birth database from the Centers for Disease Control and Prevention (2016–2021). Low-risk singleton pregnancies were included. High-risk conditions such as out-of-hospital births, fetal anomalies, pregestational and gestational diabetes, and hypertensive disorders of pregnancy were excluded. The rates of several maternal morbidities were compared among three gestational age at birth groups: 23 0/7–27 …

¡Viva Puerto Rico! How Puerto Rico's Political And Economic Status Has Affected Its Vulnerability To Natural Hazards, Mystique Quintana

University Honors Theses

Using Hurricane Maria as a case study, this thesis examines Puerto Rico's vulnerability to natural disasters and explores the intersections between colonial history, political status, and socioeconomic inequalities. Undertaking the island's susceptibility to environmental crises based on centuries of colonial exploitation and dependence, along with restrictive U.S. policies. It is argued that policies like the Jones Act, Operation Bootstrap, and PROMESA perpetuate systemic neglect and undermine disaster preparedness. Due to these structural vulnerabilities, intensified by climate change, Puerto Rico is ill-equipped to recover from hurricanes. During Hurricane Maria, systemic governance failures, inadequate infrastructure, and insufficient federal aid exposed these deep-rooted …

Mitochondrial Heteroplasmy Improves Risk Prediction For Myeloid Neoplasms, Yun Soo Hong, Sergiu Pasca, Wen Shi, Daniela Puiu, Nicole J Lake, Monkol Lek, Meng Ru, Megan L Grove, Anna Prizment, Corinne E Joshu, Elizabeth A Platz, Eliseo Guallar, Dan E Arking, Lukasz P Gondek

Faculty, Staff and Student Publications

Clonal hematopoiesis of indeterminate potential is the primary pathogenic risk factor for myeloid neoplasms, while heteroplasmy (mutations in a subset of cellular mitochondrial DNA) is another marker of clonal expansion associated with hematological malignancies. We explore how these two markers relate and influence myeloid neoplasms incidence, and their role in risk stratification. We find that heteroplasmy is more common in individuals with clonal hematopoiesis of indeterminate potential, particularly those with higher variant allele fractions, multiple mutations, or spliceosome machinery mutations. Individuals with both markers have a higher risk of myeloid neoplasms than those with either alone. Furthermore, heteroplasmic variants with …

The Zircon, November 22, 2024 [Spoof Issue], Dordt University

Dordt Diamond

No abstract provided.

Neuroprotective Effect Of L-Dopa-Induced Interleukin-13 On Striatonigral Degeneration In Cerebral Ischemia, Eunhae Jeon, Myeong-Seong Seo, Enkhmaa Lkhagva-Yondon, Yu-Ree Lim, Seung-Woo Kim, Yu Jeong Kang, Jun Seok Lee, Byoung Dae Lee, Rayul Wi, So-Yoon Won, Young Cheul Chung, Eun S Park, Eunhee Kim, Byung Kwan Jin, Myung-Shin Jeon

Faculty, Staff and Student Publications

Levodopa (L-DOPA) treatment is a clinically effective strategy for improving motor function in patients with ischemic stroke. However, the mechanisms by which modulating the dopamine system relieves the pathology of the ischemic brain remain unclear. Emerging evidence from an experimental mouse model of ischemic stroke, established by middle cerebral artery occlusion (MCAO), suggested that L-DOPA has the potential to modulate the inflammatory and immune response that occurs during a stroke. Here, we aimed to demonstrate the therapeutic effect of L-DOPA in regulating the systemic immune response and improving functional deficits in mice with ischemia. Transient MCAO led to progressive degeneration …

Towards An International, Generalizable Marketing Strategy Maturity Model, Juan Manuel Harraca

USF Tampa Graduate Theses and Dissertations

In an increasingly dynamic business environment, organizations face relentless pressure to adapt their strategies and optimize value propositions to maintain competitiveness. The formulation of effective marketing strategies has emerged as a critical factor in achieving sustainable competitive advantage and ensuring long-term success. However, many firms struggle to refine their marketing capabilities in response to evolving market demands. Addressing this challenge, the Marketing Strategy Maturity Model (MSMM), introduced by Harraca in 2023, offers a structured framework to assess and improve a firm’s marketing strategy formulation processes.

The MSMM provides a dual approach, emphasizing the enhancement of both the processes and the …

Clc-Kb Pore Mutation Disrupts Glycosylation And Triggers Distal Tubular Remodeling, Yogita Sharma, Robin Lo, Viktor N Tomilin, Kotdaji Ha, Holly Deremo, Aishwarya V Pareek, Wuxing Dong, Xiaohui Liao, Svetlana Lebedeva, Vivek Charu, Neeraja Kambham, Kerim Mutig, Oleh Pochynyuk, Vivek Bhalla

Faculty, Staff and Student Publications

Mutations in the CLCNKB gene (1p36), encoding the basolateral chloride channel ClC-Kb, cause type 3 Bartter syndrome. We identified a family with a mixed Bartter/Gitelman phenotype and early-onset kidney failure and by employing a candidate gene approach, identified what we believe is a novel homozygous mutation (CLCNKB c.499G>T [p.Gly167Cys]) in exon 6 of CLCNKB in the index patient. We then validated these results with Sanger and whole-exome sequencing. Compared with wild-type ClC-Kb, the Gly167Cys mutant conducted less current and exhibited impaired complex N-linked glycosylation in vitro. We demonstrated that loss of Gly-167, rather than gain of a mutant Cys, …

American Sign Language Educators’ Perceptions Of Incorporating Multicultural Content In U.S. Higher Education Classrooms, Noe Alexander Turcios

Walden Dissertations and Doctoral Studies

American Sign Language (ASL) courses in U.S. higher education often inadequately incorporate multicultural content, with many educators lacking knowledge of multiculturalism and relevant cultural resources. The purpose of this study was the exploration of ASL educators' perspectives on the incorporation of multicultural content in ASL classrooms and the identified barriers to doing so. The multilevel inclusion framework and the integrated framework for a culture of diversity offered a conceptual lens for the study. For this basic qualitative design, semistructured interviews were conducted with 11 ASL educators with at least 3 years of experience. In the reflexive thematic analysis of the …

Editorial: Cardiogenic Shock: Basic And Clinical Consideration, Volume Ii, Umberto Di Dedda, Indranee Rajapreyar, J. Eduardo Rame, Clement Delmas, Paolo Meani

Division of Cardiology Faculty Papers

No abstract provided.

Applications Of Computer Vision In Biomechanics And Orthopaedics, William Stewart Burton Ii

Electronic Theses and Dissertations

Machine learning has emerged as a key technology for enabling advanced computer vision systems. These systems now permeate many industries, and have enhanced traditional processes through autonomous interpretation of visual data. In the field of orthopaedics, the increasing prevalence of imaging highlights a need for similar tools. In many cases, however, direct translation of available frameworks fails to resolve the complex problems currently facing this field. Stringent performance requirements, complex visual environments, data scarcity, and implications for patient safety represent domain-specific factors which pose unique challenges to proven techniques. Novel approaches are needed to realize the full benefits of visual …

Interview With Melissa Bishop, Disability Worker, Laila Halloul

Oral Histories HIST 300, Fall 2024

Interview with Melissa Bishop about her past and current experiences in the disability field. These discussions include special education (experience and education), music education, and current job responsibilities as a disability resource provider.

Cellular Signatures In Human Blood Track Bone Mineral Density In Postmenopausal Women, Kaichi Kaneko, Jefferson Tsai, Deniece Meñez, Brian Oh, Andrew Junwoo Suh, Seyeon Bae, Masataka Mizuno, Akio Umemoto, Eugenia G. Giannopoulou, Takayuki Fujii, Yaxia Zhang, Emily M. Stein, Richard S. Bockman, Kyung-Hyun Park-Min

Publications and Research

Osteoclasts are the sole bone-resorbing cells and are formed by the fusion of osteoclast precursor cells (OCPs) derived from myeloid lineage cells. Animal studies reveal that circulating OCPs (cOCPs) in blood travel to bone and fuse with bone-resident osteoclasts. However, the characteristics of human cOCPs and their association with bone diseases remain elusive. We have identified and characterized human cOCPs and found a positive association between cOCPs and osteoclast activity. Sorted cOCPs have a higher osteoclastogenic potential than other myeloid cells and effectively differentiate into osteoclasts. cOCPs exhibit distinct morphology and transcriptomic signatures. The frequency of cOCPs in the blood …

Identification Of Lrp1+Cd13+ Human Periosteal Stem Cells That Require Lrp1 For Bone Repair, Youngjae Jeong, Lorenzo Deveza, Laura Ortinau, Kevin Lei, John R Dawson, Dongsu Park

Faculty, Staff and Students Publications

Human periosteal skeletal stem cells (P-SSCs) are critical for cortical bone maintenance and repair. However, their in vivo identity, molecular characteristics, and specific markers remain unknown. Here, single-cell sequencing revealed human periosteum contains SSC clusters expressing known SSC markers, podoplanin (PDPN) and PDGFRA. Notably, human P-SSCs, but not bone marrow SSCs, selectively expressed identified markers low density lipoprotein receptor-related protein 1 (LRP1) and CD13. These LRP1+CD13+ human P-SSCs were perivascular cells with high osteochondrogenic but minimal adipogenic potential. Upon transplantation into bone injuries in mice, they preserved self-renewal capability in vivo. Single-cell analysis of mouse periosteum further supported the preferential …

A Proteogenomic Analysis Of Cervical Cancer Reveals Therapeutic And Biological Insights, Jing Yu, Xiuqi Gui, Yunhao Zou, Qian Liu, Zhicheng Yang, Jusheng An, Xuan Guo, Kaihua Wang, Jiaming Guo, Manni Huang, Shuhan Zhou, Jing Zuo, Yimin Chen, Lu Deng, Guangwen Yuan, Ning Li, Yan Song, Jia Jia, Jia Zeng, Yuxi Zhao, Xianming Liu, Xiaoxian Du, Yansheng Liu, Pei Wang, Bing Zhang, Li Ding, Ana I Robles, Henry Rodriguez, Hu Zhou, Zhen Shao, Lingying Wu, Daming Gao

Faculty, Staff and Students Publications

Although the incidence of cervical cancer (CC) has been reduced in high-income countries due to human papillomavirus (HPV) vaccination and screening strategies, it remains a significant public health issue that poses a threat to women's health in low-income countries. Here, we perform a comprehensive proteogenomic profiling of CC tumors obtained from 139 Chinese women. Integrated proteogenomic analysis links genetic aberrations to downstream pathogenesis-related pathways and reveals the landscape of HPV-associated multi-omic changes. EP300 is found to enhance the acetylation of FOSL2-K222, consequently accelerating the malignant proliferation of CC cells. Proteomic stratification identifies three patient subgroups with distinct features in prognosis, …

Crowdsourcing Reviews Of Reported Content

Defensive Publications Series

Methods, systems, and storage media for crowdsourcing reviews of reported content are disclosed. Exemplary implementations may: receive, by a communication network, a content post; receive a report that the post violates a policy of the communication network; classify, based on the report, a policy violation of the post; determine, based on the classification, to provide the post to one or more users of the communication network or to an administrator of the communication network for review; determine, based on determining to provide the post to the one or more users of the communication network, one or more reviewers to review …

A Family Affair: Family And Feminism In Contemporary Irish Women's Fiction, Mary Ryan

Budhi: A Journal of Ideas and Culture

Despite the fact that the contemporary women’s fiction genre of chick lit is most commonly considered in terms of its apparent focus on romantic relationships, this paper suggests that these are not the only relationships that chick lit heroines embark on. Examining a selection of specifically Irish chick lit novels, this paper explores how they present Irish families in the twenty f irst century, and discusses the genre’s demonstration of how the notion of “family” is changing for many Irish women who, no longer secluded and repressed within the home as many Irish women once were, now increasingly f ind …

Librarian Instruction Of Researcher Profile Systems To Graduate Students: A Case Study, Caroline Monnin, Justin Fuhr

Journal of Graduate Librarianship

Introduction: Academic liaison librarians play a pivotal role in supporting graduate students with their scholarly endeavors, particularly research dissemination. Researcher profile systems (RPSs) are important for promoting academic work; they ensure name attribution and facilitate research distribution. Academic librarians are advocates of these systems and provide support and instruction for them. This article reports on a pre–post survey evaluating a library workshop on RPSs for graduate students, as well as the changes made to the workshop based on the results of the survey.

Methods: The authors co-taught a workshop about RPSs six times between 2021 and 2022. Pre- and post-surveys …

Interview With Blanche Crosson, Sheldon Hamilton

Kansas Oral History Collection

An interview with Blanche Evelyn Gatten Crosson (1905-1972) on the topic of life during the Great Depression.

00:00:15 - Biographical information
00:01:37 - Entertainment on the farm
00:02:27 - Every day life
00:03:03 - Childhood illnesses
00:04:19 - Schooling
00:05:25 - The Great Depression
00:08:00 - Prohibition
00:10:00 - Entertainment during the period
00:11:10 - Surviving economically during the Depression
00:12:05 - World War II
00:15:20 - Work as a nurse in Dighton, KS

Vol. 12, No. 6, Glen Goodknight

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Vol. 12, No. 5, Glen Goodknight

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Vol. 12, No. 4, Glen Goodknight

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Vol. 12, No. 3, Glen Goodknight

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Vol. 12, No. 2, Glen Goodknight

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Vol. 12, No. 1, Glen Goodknight

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.