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Articles 6511 - 6540 of 1439291
Full-Text Articles in Entire DC Network
Defying Impossibility: Critical Qualitative Reorientations To Black Lgbtqia+ Sense Of Belonging, Olivia H. Hunte
Defying Impossibility: Critical Qualitative Reorientations To Black Lgbtqia+ Sense Of Belonging, Olivia H. Hunte
Electronic Theses and Dissertations
Belonging is a human need central to survival and can be cultivated within all spheres of life. Social environments are vital for experiencing a sense of belonging. In some social environments, Black LGBTQIA+ people encounter greater impediments to their daily lives with consequences for survival, including threatening their belonging needs. Within the United States, systems of oppression create and inform conditions within social environments that can potentially thwart pathways to belonging for Black LGBTQIA+ people. Thus, fulfillment of belonging needs for Black LGBTQIA+ people is one of nuance, pain, resilience, hope, harm, trauma, resistance, and healing; scant research is available …
Don't Self-Opt Out Of Career Opportunities: Proceed With Confidence, Valerie Mendoza
Don't Self-Opt Out Of Career Opportunities: Proceed With Confidence, Valerie Mendoza
Faculty Publications
While reflecting on your career in the past, have you ever stepped back from an opportunity that you wanted because you doubted yourself? In the workplace, confidence often gets mistaken for competence, and that means talented employees can be overlooked simply because they hesitate. The truth is that confidence isn’t something you’re born with. It’s a skill you can build. This session will get you started on building that skill.
We’ll explore practical strategies to strengthen your confidence starting today. We’ll also break down the key differences between how confident individuals act compared to those who aren’t, so you can …
Glycosphingolipids Regulate Phosphatidylserine Transport Machinery That Operates At Er-Pm Contact Sites, Ritchel Gannaban, Sher Ali, Wei Chen, Melanie Nguyen, Li Lai, Travis I Moore, Yubin Zhou, John F Hancock, Junchen Liu
Glycosphingolipids Regulate Phosphatidylserine Transport Machinery That Operates At Er-Pm Contact Sites, Ritchel Gannaban, Sher Ali, Wei Chen, Melanie Nguyen, Li Lai, Travis I Moore, Yubin Zhou, John F Hancock, Junchen Liu
The Brown Foundation: Institute of Molecular Medicine
Plasma membrane (PM) localization of KRAS requires specific glycosphingolipids in the outer leaflet and phosphatidylserine (PS) in the inner leaflet. PM PS content is controlled by lipid transport proteins ORP5 and ORP8, which operate at ER-PM membrane contact sites (MCSs). Using high-resolution imaging, we now show that GSLs, including GM3 and SM4, are required to maintain ORP5 and ORP8 localization to MCSs. Genetic deletion or pharmacologic inhibition of enzymes required for the biosynthesis of GM3 or SM4 displaces PI4-kinase Type IIIα (PI4KIIIα) and its adaptor EFR3A from the PM, thereby reducing PM phosphatidylinositol 4-phosphate (PI4P) content. PM interactions of ORP5 …
Higher Education Institutions In U.S. Blockchain Innovation Governance Documents, Clarissa Terracciano
Higher Education Institutions In U.S. Blockchain Innovation Governance Documents, Clarissa Terracciano
Electronic Theses and Dissertations
Blockchain technologies have attracted growing attention as an evolution of digital recordkeeping, prompting interest in higher education governance, credentialing, and data management. Yet, no systematic analysis exists on how U.S. government blockchain documents define institutional roles and governance authority within higher education institutions. As the national blockchain innovation system expands through governance infrastructure, the inclusion of higher education institutions as governing actors is imperative for coherent and equitable deployment. This qualitative study examines what roles the U.S. government blockchain documents assign to higher education institutions within the national blockchain innovation system.
Using innovation systems theory, particularly the triple-helix model of …
Exploring Engineering Technology: A Multi-Year, Multidisciplinary Project-Based Engineering Technology Workshop, Benito Mendoza, Angran Xiao, Muhammad Ummy
Exploring Engineering Technology: A Multi-Year, Multidisciplinary Project-Based Engineering Technology Workshop, Benito Mendoza, Angran Xiao, Muhammad Ummy
Publications and Research
Many students enter engineering technology programs with a limited understanding of disciplinary differences, curricular expectations, and career pathways, contributing to early dissatisfaction and attrition. To address this challenge, we developed Exploring Engineering Technology, a multidisciplinary, project-based workshop that introduces students to Mechanical, Electrical, and Computer Engineering Technology through a shared robotic systems project. This paper presents a multi-year design-based educational research (DBER) study documenting the iterative refinement and sustained implementation of the workshop across three consecutive summers (2023–2025) at a large urban public college. Using a consistent post-workshop survey administered across cohorts and aggregate student progression indicators, we examine …
Apolipoprotein B100 Predicts Cardiovascular And Limb Events In Type 2 Diabetes Patients With Chronic Limb-Threatening Ischemia, Federico Biscetti, Maria Margherita Rando, Maria Anna Nicolazzi, Flavia Angelini, Roberto Iezzi, Luis H. Eraso, Paul J. Dimuzio, Dario Pitocco, Massimo Massetti, Antonio Gasbarrini, Andrea Flex
Apolipoprotein B100 Predicts Cardiovascular And Limb Events In Type 2 Diabetes Patients With Chronic Limb-Threatening Ischemia, Federico Biscetti, Maria Margherita Rando, Maria Anna Nicolazzi, Flavia Angelini, Roberto Iezzi, Luis H. Eraso, Paul J. Dimuzio, Dario Pitocco, Massimo Massetti, Antonio Gasbarrini, Andrea Flex
Department of Surgery Faculty Papers
BACKGROUND: Patients with type 2 diabetes mellitus (T2DM) and chronic limb-threatening ischemia (CLTI) undergoing lower extremity revascularization (LER) face high risks of major adverse cardiovascular events (MACE) and major adverse limb events (MALE), despite guideline-directed lipid-lowering therapy. Apolipoprotein B100 (ApoB100), reflecting total atherogenic particle number, may identify residual risk beyond LDL-cholesterol (LDL-C). Therefore, we investigated whether baseline ApoB100 levels independently predict MACE and MALE beyond conventional risk factors in this high-risk population.
METHODS: In this prospective cohort study, 167 T2DM patients with CLTI undergoing LER were followed for 12 months with visits at 1, 3, 6, and 12 months post-procedure. …
Cover And Contents
Turkish Journal of Veterinary & Animal Sciences
No abstract provided.
Determination Of Hematobiochemical Parameters And Egg Quality Traits Of Turkish Sultan Chickens, Mehmet Naci̇ Oktay, Ruhi̇ Kabakçi, Ali̇ Karapinar, Gökhan Şen, Taha Altuğ, Yasi̇n Şenel
Determination Of Hematobiochemical Parameters And Egg Quality Traits Of Turkish Sultan Chickens, Mehmet Naci̇ Oktay, Ruhi̇ Kabakçi, Ali̇ Karapinar, Gökhan Şen, Taha Altuğ, Yasi̇n Şenel
Turkish Journal of Veterinary & Animal Sciences
The present study aimed to investigate the hematological and biochemical blood parameters, along with selected egg quality traits, of Turkish Sultan chickens. A total of 90 blood samples collected from 60-week-old hens and roosters and 129 eggs collected from 50 hens were analyzed. The findings showed that hematological parameters such as red blood cells (RBC), hemoglobin (HGB), packed cell volume (PCV), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), and heterophil-to-lymphocyte (H/L) ratio, as well as biochemical markers such as aspartate aminotransferase (AST), lactate dehydrogenase (LDH), and uric acid levels, were significantly higher in roosters. The average egg weight, shape …
The In Vitro Feeding Of Hyalomma Marginatum (Koch, 1844), Nesli̇han Ölmez, Bariş Sari, Zati̇ Vatansever
The In Vitro Feeding Of Hyalomma Marginatum (Koch, 1844), Nesli̇han Ölmez, Bariş Sari, Zati̇ Vatansever
Turkish Journal of Veterinary & Animal Sciences
Ticks are obligate hematophagous ectoparasites that play a major role in the transmission of pathogens affecting both animals and humans. Investigations into tick biology, pathogen transmission, and the development of effective control strategies have traditionally depended on the extensive use of laboratory animals. Consequently, the development of reliable in vitro feeding systems is a valuable alternative approach with the potential to reduce animal use in tick research. In the present study, a previously described silicone membrane artificial feeding system was modified and applied for the in vitro feeding of Hyalomma marginatum (Koch, 1844). Feeding units were prepared using bovine blood …
Chatbot-Based Feedback + Revision And Reflection For Lab Reports, Janie Brennan
Chatbot-Based Feedback + Revision And Reflection For Lab Reports, Janie Brennan
Generative AI Teaching Activities
Students will upload draft versions of laboratory reports to a specially designed chatbot trained on course guidelines and instructor preferences. The chatbot gives structured feedback on the submission, and then students update their work and write a reflection about the experience.
Investigating The Interactions Of Auxiliary Subunits With The Nav1.5 Channel, Lucy Summer Woodbury
Investigating The Interactions Of Auxiliary Subunits With The Nav1.5 Channel, Lucy Summer Woodbury
McKelvey School of Engineering Graduate Student Theses & Dissertations
The voltage-gated Nav1.5 channel is responsible for the rapid depolarization of the cardiac action potential. A key feature of the Nav1.5 channel is its rapid activation and inactivation. The C-terminal domain (CTD) of Nav1.5 and subsequent auxiliary subunits that bind there can influence the gating kinetics of Nav1.5. In particular, intracellular fibroblast growth factors (iFGFs) and calmodulin (CaM) both shift the voltage-dependence of inactivation, or steady-state inactivation (SSI), in a depolarizing manner. Recently, a non-canonical CaM binding site was discovered on the A-splice variants of iFGFs. As FGF12A and CaM can interact with each other independent of Nav1.5, a model …
Oriented Electrospun Fibers Of Poly(Pro-Curcumin/Peg) Sequester Reactive Oxygen Species And Promote The Growth Of Schwann Cells, Jack W. Devlin, Payton R. O'Connor, Conrad H. Cheung, John T. Leman, Martin Oudega, Edmund F. Palermo, Ryan J. Gilbert
Oriented Electrospun Fibers Of Poly(Pro-Curcumin/Peg) Sequester Reactive Oxygen Species And Promote The Growth Of Schwann Cells, Jack W. Devlin, Payton R. O'Connor, Conrad H. Cheung, John T. Leman, Martin Oudega, Edmund F. Palermo, Ryan J. Gilbert
Chemical and Biochemical Engineering Faculty Research & Creative Works
In the biological injury microenvironment, pathologically elevated oxidative stress hinders healthy cell migration. Aligned electrospun fibers are used as tissue engineering scaffolds to support and guide the directionality of cell migration. The ability of cells in the central nervous system to sequester and quench reactive oxygen species is limited, and most electrospun fibers do not exert any antioxidant activity on contact. Thus, the challenge remains in designing a scaffold that can both guide cells to the injury site as well as sequester and quench excess free radicals, allowing cells to thrive and potentially regenerate. Curcumin is a well-known, potent antioxidant, …
Lost In Loss: A Supportive Handbook For Teens Grieving The Suicide Of A Loved One, Gabriella Potter
Lost In Loss: A Supportive Handbook For Teens Grieving The Suicide Of A Loved One, Gabriella Potter
Graduate School of Professional Psychology: Doctoral Papers and Masters Projects
Adolescence is a complex developmental time. For adolescents grieving a suicide death, there can be added layers of complexity in navigating this developmental period, due to unique challenges and stigma, family disruption, trauma, unanswerable questions, feelings of rejection, abandonment, responsibility, and anger that can result from a suicide death loss. Through a literature review of the available research on adolescent suicide bereavement, this doctoral paper examines models of grief, adolescent development, and suicide loss, aiming to bridge the literature in all these domains. Despite the high prevalence of bereavement in young people, there are limited, tailored resources designed to support …
Driving Development: Coalitions, Policies, And Upgrading Brazilian Automotive Technology (1988–2025), Henrique Estides Delgado
Driving Development: Coalitions, Policies, And Upgrading Brazilian Automotive Technology (1988–2025), Henrique Estides Delgado
Electronic Theses and Dissertations
Among industrial activities in Brazil, the automotive sector generates some of the most significant and multifaceted multiplier effects on the country’s gross domestic product (GDP). The sector integrates activities ranging from raw materials to high-tech services, incorporating advanced technologies that influence innovation and positioning in global value chains (GVCs). Remarkably, this industry has been structured over time by public policies that have decisively shaped incentives for its participants. The world’s largest automotive multinationals have been attracted to operate in the country through varied institutional arrangements involving domestic capital and incentives across federative units. This dissertation analyzes how variations in institutional …
Difficult History During Difficult Times: Amache Junior Rangers, Katelyn Morkovsky
Difficult History During Difficult Times: Amache Junior Rangers, Katelyn Morkovsky
Electronic Theses and Dissertations
My research aims to understand approaches to teaching difficult histories to children at cultural heritage institutions. To do this, I examined the creation process of the Amache Junior Ranger booklet that launched at the site in the fall of 2025. Amache, a WWII Japanese American incarceration center, presents significant interpretive challenges in balancing the traumatic nature of the site with age-appropriate content as well as highlighting the agency people exercised without losing the gravity of the situation. In addition to how the booklet was made, I use my research to situate the booklet in the social and political climate in …
The Republican Party And The Creation Of The Bipartisan Foreign Policy, 1945-1953, Alexander Gellos
The Republican Party And The Creation Of The Bipartisan Foreign Policy, 1945-1953, Alexander Gellos
Electronic Theses and Dissertations
This thesis provides a historical and structural reexamination of the Republican Party’s role in shaping American foreign policy from 1945 to 1953. Defying the historiography of a frictionless postwar consensus and an executive branch-centered narrative, this historical chronological study demonstrates that the Republican Party’s role in formulating the bipartisan foreign policy was a contingent and debated legislative construction. Far from representing passive submission or a surrender of partisan identity, the GOP’s role was an indispensable exercise in creating it, and due to politics being what it is, straining it. Through historical chronology spanning from 1945 to 1953, the party's center …
Voice And Choice: Exploring The Role Of Student Agency In High School Math Course Placement, Anne Patia Carpenter Sterry
Voice And Choice: Exploring The Role Of Student Agency In High School Math Course Placement, Anne Patia Carpenter Sterry
Electronic Theses and Dissertations
This study examined how students make sense of the mathematics placement process within a high-rigor independent school. In contexts where placement decisions shape access to advanced coursework, students’ interpretations of these decisions may influence both their academic trajectories and their developing mathematical identities. The purpose of this qualitative bounded case study was to understand the experiences of students who enrolled in mathematics courses that differed from placement recommendations, focusing on their motivations for self-selection, their interpretations of feedback from adults and peers, and how these experiences shaped their mathematical identities.
Data were collected through semi-structured interviews with 10 high school …
Heroes At Home: Developing And Evaluating A Comprehensive Parenting Program For Expectant Parents And Parents Of Young Children, Olivia Adams
Graduate School of Professional Psychology: Doctoral Papers and Masters Projects
Parental preparedness plays a critical role in parental wellbeing, relationship functioning, and early child development; however, many parents report feeling unprepared for the emotional, relational, and developmental demands of parenthood. Although psychoeducational parenting programs have demonstrated positive effects on parental mental health and child outcomes, access to comprehensive and time-efficient interventions remains limited. This pilot program evaluation assessed the feasibility and preliminary outcomes of a brief, online psychoeducational parenting program designed to reduce parenting stress and enhance parental self-efficacy. A quasi-experimental pre–post design was used to examine changes in parenting stress and parental self-efficacy following participation in a single 120-minute …
A Narrative Study Of The “Religious Dones” And Their Religious Identity, Relationship To God, And Social Connections, Michelle Suh
A Narrative Study Of The “Religious Dones” And Their Religious Identity, Relationship To God, And Social Connections, Michelle Suh
Graduate School of Professional Psychology: Doctoral Papers and Masters Projects
This qualitative study aims to learn about how religious dones — those who were formerly religious but no longer identify as religious — have constructed their life narratives in light of their religious deidentification, with particular attention on the evolution of religious identity, perceived relationship with God, and social connections across the lifespan. A narrative methodology was employed to capture participants’ experiences in a story format to understand the subjective meaning-making process of their lived experiences, and six young adults between the ages of 23-29 participated in the study. Data collection consisted of a life-story portion of the interview with …
Motherwise In Nicaragua: The Implementation Of Culturally Adapted Relationship Education For Women During Pregnancy And Postpartum, Amanda Key Correa Love
Motherwise In Nicaragua: The Implementation Of Culturally Adapted Relationship Education For Women During Pregnancy And Postpartum, Amanda Key Correa Love
Graduate School of Professional Psychology: Doctoral Papers and Masters Projects
Intimate partner violence (IPV) is a concerning public health issue of global proportions, particularly within rural and under-resourced settings. Communities in these settings face elevated risk for relationship abuse, further compounded by barriers to access culturally responsive preventive intervention programming. This qualitative study investigated participant experiences, cultural adaptation, and implementation of the MotherWise program, a healthy relationship education intervention in rural Leon, Nicaragua. Semi-structured interviews were conducted with former and current program participants as well as the program facilitator following the initial program implementation. Data were analyzed using thematic analysis to identify patterns related to participant experiences, the types of …
Fort Hays State University Tiger Weekly, June 12, 2026, University Relations
Fort Hays State University Tiger Weekly, June 12, 2026, University Relations
Tiger Weekly Newsletters
No abstract provided.
Artificial Intelligence In Biomedical Scientific Publishing, Tomasz J Guzik, Victor Aboyans, Stefan Agewall, Steven Bailey, Adrian Baranchuk, Magnus Bäck, Michael Böhm, Robert O Bonow, George W Booz, Giuseppe Boriani, Biykem Bozkurt, Nico Bruining, Davide Capodanno, Çetin Erol, Péter Ferdinandy, Alessia Gimelli, Gerd Heusch, Thomas Kahan, Chim Choy Lang, Gerald Maurer, Robert J Mentz, Marco Metra, Philip Moons, Daniel Piskorz, Massimo Piepoli, Piotr Ponikowski, Alexandra Popma, Bianca Rocca, Juan Sanchis Fores, Philipp Sommer, Rhian M Touyz, Zoltan Ungvari, Pascal Vranckx, Joseph A Hill, Thomas F Lüscher, Filippo Crea
Artificial Intelligence In Biomedical Scientific Publishing, Tomasz J Guzik, Victor Aboyans, Stefan Agewall, Steven Bailey, Adrian Baranchuk, Magnus Bäck, Michael Böhm, Robert O Bonow, George W Booz, Giuseppe Boriani, Biykem Bozkurt, Nico Bruining, Davide Capodanno, Çetin Erol, Péter Ferdinandy, Alessia Gimelli, Gerd Heusch, Thomas Kahan, Chim Choy Lang, Gerald Maurer, Robert J Mentz, Marco Metra, Philip Moons, Daniel Piskorz, Massimo Piepoli, Piotr Ponikowski, Alexandra Popma, Bianca Rocca, Juan Sanchis Fores, Philipp Sommer, Rhian M Touyz, Zoltan Ungvari, Pascal Vranckx, Joseph A Hill, Thomas F Lüscher, Filippo Crea
Faculty, Staff and Students Publications
Artificial intelligence is now embedded across the scientific research and publishing ecosystem, influencing discovery, analysis, knowledge translation, authorship, peer review, and editorial workflows. In cardiovascular and biomedical sciences, these developments offer substantial opportunities to accelerate knowledge generation, integrate complex datasets, and improve efficiency and consistency. At the same time, they introduce new risks related to bias, transparency, data integrity, and authorship responsibility, potentially endangering trust in the scientific record. This commentary examines the evolving role of AI in biomedical publishing, with particular attention to generative models and machine learning tools. We review both benefits and limitations, highlight risks such as …
Single-Nucleus Profiling Reveals A Core Disease Signature And Cell Type-Specific Vulnerabilities In Early Rett Syndrome, Yan Li, Ashley G Anderson, Guantong Qi, Sih-Rong Wu, Jean-Pierre Revelli, Hu Chen, Zhandong Liu, Huda Y Zoghbi
Single-Nucleus Profiling Reveals A Core Disease Signature And Cell Type-Specific Vulnerabilities In Early Rett Syndrome, Yan Li, Ashley G Anderson, Guantong Qi, Sih-Rong Wu, Jean-Pierre Revelli, Hu Chen, Zhandong Liu, Huda Y Zoghbi
Faculty, Staff and Students Publications
Rett syndrome (RTT) is an X-linked neurological disorder caused by MECP2 mutations, creating distinct cellular environments in females (mosaic) versus males (nonmosaic). Despite female patients representing most cases, how mosaicism contributes molecularly to RTT pathogenesis, particularly in presymptomatic stages, remains poorly understood. To address this question, we profiled hippocampal transcriptomes of young female and male RTT mice using bulk and single-nucleus RNA sequencing. We identified a core disease signature of consistently dysregulated genes only in MeCP2− cells across RTT models. Moreover, we uncovered non–cell autonomous effects exclusively in female MeCP2+ excitatory neurons, suggesting that these circuits are more vulnerable early …
Singing As Liberation: Spiritual Imagination And An Embodied Practice Of Hope Through Spirituals And Songs Of The Uhadi, Matisse Geselle
Singing As Liberation: Spiritual Imagination And An Embodied Practice Of Hope Through Spirituals And Songs Of The Uhadi, Matisse Geselle
University Honors Theses
An exploration of the spirituality and the sacredness of music—and especially singing—through recording my own interpretations of spirituals and songs of the uHadi. It is also a poetic inquiry into how imagery of the river is used in spirituals as a pathway to freedom and liberation, and how the singing of spirituals is hope embodied. And it is a reflection of how my experience of the uHadi and my friends of the Ibuyambo ensemble changed me. The process of working on this project also feels like I am connecting to myself—and others—more deeply through singing. And ultimately, I hope for …
Navigating Filipino-American Identity Through Philippine Foodways, Jenelle Kirsten De Leon
Navigating Filipino-American Identity Through Philippine Foodways, Jenelle Kirsten De Leon
University Honors Theses
This thesis examines the complexity of Filipino-American identity and investigates how Philippine foodways can function as a meaningful pathway for cultural understanding, identity formation, and intergenerational connection. Shaped by colonization, cultural hybridity, generational divides, and limited representation in Western education and media, Filipino-American identity is often difficult to define and navigate, leaving many individuals without accessible entry points to explore their culture, history, traditions, and more.
Through an analysis of existing literature, primary research, and a survey of Filipino-American youth, this study finds that Filipino cuisine operates as a powerful site of cultural and historical knowledge. The narratives embedded within …
Characteristics Of Social Capital In Informal Housing Settlements, Lena Parsons
Characteristics Of Social Capital In Informal Housing Settlements, Lena Parsons
University Honors Theses
Many cities see growth of informal housing settlements as urban populations rise across the globe. Residents of informal settlements are observed to use robust networks of social capital to support themselves in an environment of resource scarcity and marginalization. This review synthesizes research examining characteristics of social capital in informal housing settlements, finding that (1) social capital influences residents' acquisition of basic needs, (2) the structure of social capital networks depend on the context of the settlement, and (3) the built environment of informal settlements has a cyclical relationship to their social capital networks. This synthesis concludes that formal solutions …
In Work But Out Of Rights: Migration Governance And The Production Of Precarity Among Third-Country Nationals In Cyprus’ Hotel Sector, Petros Giannoulis, Petros Kosmas, Maria Panagopoulou
In Work But Out Of Rights: Migration Governance And The Production Of Precarity Among Third-Country Nationals In Cyprus’ Hotel Sector, Petros Giannoulis, Petros Kosmas, Maria Panagopoulou
Irish Journal of Tourism, Hospitality, Leisure and Event Research
This study aims to examine how migration and labour governance in Cyprus produces and manages precarity among Third-Country Nationals (TCNs) employed in the hotel sector. For the purposes of the present study this category encompasses various groups of people, including Non-EU migrant workers, international students and asylum seekers. Drawing on critical scholarship on migration governance, differential inclusion, and institutional racism, the study analyses key policy instruments regulating the recruitment, employment and residence of migrant workers through qualitative content analysis. The findings demonstrate that precarity is not an unintended by-product of labour market regulation or administrative failure, but a structurally embedded …
Differentiation Of Self As A Therapist Effect In Couple Therapy, Nathan D. Knebel
Differentiation Of Self As A Therapist Effect In Couple Therapy, Nathan D. Knebel
Theses and Dissertations
Murray Bowen proposed that a therapist's level of differentiation of self influences therapeutic effectiveness, particularly in clinically distressed relational systems. Although existing literature has demonstrated that therapist effects account for a meaningful portion of variance in couple therapy outcomes, differentiation of self has received limited empirical attention as a therapist-level predictor. The present article proposes a framework for empirically examining Bowen's hypothesis by investigating whether therapist differentiation predicts trajectories of couple relationship quality across treatment. Additionally, the article explores theoretical pathways through which therapists may increase their level of differentiation, assuming Bowen's hypothesis is supported.
Defining Replication-Driven Vulnerabilities In High Grade Serous Ovarian Cancers, Natasha Maya Ramakrishnan
Defining Replication-Driven Vulnerabilities In High Grade Serous Ovarian Cancers, Natasha Maya Ramakrishnan
Arts & Sciences Graduate Student Theses and Dissertations
High grade serous ovarian carcinoma (HGSOC) is an aggressive, highly lethal subtype of ovarian cancer. These cancers are typically diagnosed in later stages and are associated with poor patient prognosis. Additionally, HGSOC is characterized by numerous markers of genomic instability and defects in DNA repair pathways, vulnerabilities which have been exploited by the advancement of chemotherapy. Despite these clinical advancements, HGSOC remains a significant therapeutic challenge due to emergence of chemoresistance and limited targeted treatment options. Taken together, these factors highlight an ongoing need to study the development of HGSOC and its progression to identify more effective treatment opportunities. We …
Bap1 Loss Links Myc Activation, Stress Response Vulnerability, And Disease Progression In Kidney Cancer, Ilya Strunilin
Bap1 Loss Links Myc Activation, Stress Response Vulnerability, And Disease Progression In Kidney Cancer, Ilya Strunilin
Arts & Sciences Graduate Student Theses and Dissertations
BAP1, a chromatin modifier, is a frequently mutated tumor suppressor in clear cell renal cell carcinoma (ccRCC). Mutations in BAP1 are associated with a more aggressive and lethal disease. However, the downstream mediators of BAP1 loss in ccRCC oncogenesis are not well understood. To better understand mechanisms of BAP1-mediated tumor suppression, I have extensively characterized the very early transcriptional mediators of BAP1 loss in a postnatal kidney-specific genetic knockout model. Because VHL loss is the initiating event in ccRCC, we modeled Bap1 loss in a Vhl-deficient background. I have found that Vhl/Bap1 double-knockout cells of PT segment S2 strongly activate …