Digital Commons Network^™

Kinematics And Age Of The Afyon Zone In The Akhisar Region, Western Türkiye, Tali̇p Güngör, İsmai̇l İşi̇ntek, Erhan Akay, Cüneyt Akal, Altuğ Hasözbek, Ahmed Erbi̇l, Axel Gerdes

Turkish Journal of Earth Sciences

In western Anatolia, to the south of the İzmir-Ankara Suture, Menderes Massif, Cycladic Blueschists, Afyon Zone and Bornova Mélange form the main tectonic belts from structurally bottom to top. In the Akhisar region, the Akhisar Nappe consists of Hasköy Formation, below, and Görenez Limestone, above. The Hasköy Formation is composed of a metaclastic sequence with metarhyolite intercalations (237.4 ± 1.1 Ma, zircon LA-ICP-MS) and recrystallized limestone lenses, and it gradually passes upward into late Norian-Early Jurassic Görenez Limestone. New radiogenic data from metarhyolites of the Hasköy Formation and fossil determinations from recrystallized limestones of the Görenez Limestone show that the …

Artificial Intelligence For Optical Coherence Tomography In Glaucoma, Mak B. Djulbegovic, Henry Bair, David J. Taylor Gonzalez, Hiroshi Ishikawa, Gadi Wollstein, Joel S. Schuman

Wills Eye Hospital Papers

PURPOSE: The integration of artificial intelligence (AI), particularly deep learning (DL), with optical coherence tomography (OCT) offers significant opportunities in the diagnosis and management of glaucoma. This article explores the application of various DL models in enhancing OCT capabilities and addresses the challenges associated with their clinical implementation.

METHODS: A review of articles utilizing DL models was conducted, including convolutional neural networks (CNNs), recurrent neural networks (RNNs), generative adversarial networks (GANs), autoencoders, and large language models (LLMs). Key developments and practical applications of these models in OCT image analysis were emphasized, particularly in the context of enhancing image quality, glaucoma …

Using Rna-Sequencing To Explore Mechanistic Markers, New Therapeutics, And Immune Imbalance: A Study Of Cancer And Autoimmunity Through The Lens Of Triple Negative Breast Cancer, Systemic Lupus Erythematosus, And B-Cell Non-Hodgkin's Lymphoma, Naomi Lydia Rapier-Sharman

Theses and Dissertations

Cancer and autoimmune diseases both impose a substantial healthcare burden on the US and world populations. In 2016, there were over 17 million cases of cancer, leading to nearly nine million deaths. Additionally, autoimmune diseases cause substantial mortality and morbidity and are present in 3-5% of the general population. Despite the increased attention scientists now give diseases that are impacted by immune imbalance, we have yet to find regimens to treat the core cause(s) of tissue dysfunction without drastically decreasing the quality of life for many patients with either cancer or autoimmune disease. For instance, anti-CD19 Chimeric Antigen Receptor (CAR) …

Ypfs Lessons Learned Oral History Project: An Interview With Pedro Machado, Pedro Machado, Mercedes Cardona

Documents

No abstract provided.

The Student Movement Volume 109 Issue 11: Inaugurating The New Semester, Esther Martin, Ayanda Dewa, Aiko J. Ayala Rios, Callie Carlsen, Timi Olatunde, Madison Vath, Rod Olofernes, Nora Martin, Lexie Dunham, Nate Miller

The Student Movement V. 109 (2024-2025)

HUMANS

New Year, New Me or New Year, Same Me?, Esther Martin

Season's Celebrations, Ayanda Dewa

ARTS & ENTERTAINMENT

Schubertiade Afternoon of Piano and Voice, Aiko J. Ayala Rios

NEWS

A History of the Inauguration, Callie Carlsen

IDEAS

Are New Year's Resolutions Worth It?, Timi Olatunde

TikTok: The Political Weapon, Madison Vath

TikTok, Your Time is Up, Rod Olofernes

PULSE

An Overview of Trump's Second Cabinet, Nora Martin

Winter in Michigan, Lexie Dunham

LAST WORD

Slammed, Again, Nate Miller

Atm Expression And Activation In Ataxia Telangiectasia Patients With And Without Class Switch Recombination Defects, Fereshte Salami, Tannaz Moeini Shad, Nazanin Fathi, Hanieh Mojtahedi, Marzie Esmaeili, Sepideh Shahkarami, Ladan Gol Mohammad Pour Afrakoti, Parisa Amirifar, Samaneh Delavari, Hassan Nosrati, Azadehsadat Razavi, Mohammad Reza Ranjouri, Mahsa Yousefpour, Zahra Hamidi Esfahani, Gholamreza Azizi, Mahmoudreza Ashrafi, Nima Rezaei, Reza Yazdani, Hassan Abolhassani

Department of Neurology Faculty Papers

BACKGROUND: Ataxia telangiectasia mutated (ATM) kinase plays a critical role in DNA double-strand break (DSB) repair. Ataxia telangiectasia (A-T) patients exhibit abnormalities in immunoglobulin isotype expression and class switch recombination (CSR). This study investigates the role of residual ATM kinase expression and activity in the severity of A-T disease.

METHODS: A-T patients with defined genetic diagnoses were classified based on CSR and based on the severity of their medical complications. Isolated peripheral blood mononuclear cells from any patient were evaluated before and after exposure to 0.5 Gy ionizing radiation for one minute. Western blotting was performed to identify the expression …

Social, Racial, And Economic Disparities Affecting Outcomes Of Hypertensive Adolescents, Kanya Singhapakdi, Amelia Haydel, Marla Johnston, Shengping Yang, Tamara Bradford, Dedrick Moulton, Thomas R. Kimball

School of Medicine Faculty Publications

Essential hypertension is one of the most common conditions managed in pediatric cardiology and can result in lasting deleterious effects on the cardiovascular system. Pediatric hypertension is so prevalent in the United States that it is often referred to as a public health challenge. Social determinants of health (SDH) are the cultural, economic, educational, healthcare accessibility, and political influences in the environment in which an individual is born or lives, all of which can affect that individual's overall health. This study investigated the impact of social determinants such as rurality, food insecurity, transportation challenges, minority status, income, and race on …

Improper Fitting Personal Protective Clothing And Subsequent Countermeasures For Physical Conditioning In Female Firefighters: A Narrative Review, Katie Sell, Mark Abel, J. Jay Dawes, Megan Thompson, Annette Zapp, Ofra Pottorf, Lilly Bernardi, James Prendergast

International Journal of Physical Activity and Health

The purpose of this paper was to 1) use an explorative literature overview to identify issues related to ill-fitting clothing and occupational gear for female firefighters, and 2) use an inductive approach to develop generalizable recommendations for exercise professionals to utilize by identifying significant themes in published peer reviewed articles related to movement and injury risk. Research, including both qualitative and quantitative approaches, has shown that the majority of current personal protective clothing (PPC) and operational gear was developed to fit a limited array of male physiques. Consequently, the improper fit of PPC and gear has presented numerous concerns that, …

Prevalence Of Autoimmune Diseases In Patients Treated With Immune Checkpoint Inhibitors: An Epidemiological Study Using A Global Network Of Health Care Organizations, Pushti Khandwala, Devashish Desai, Arthur Lau

Einstein Health Papers

OBJECTIVE: Evaluate prevalence of new onset autoimmune conditions (ACs) after commencement of immune checkpoint inhibitors (ICIs).

METHODS: This retrospective observational study was done using TriNetX. Patients with neoplasm for which ICIs were approved were stratified into two groups based on ICI use. Multivariate Cox proportional hazard models and Kaplan Meier method were used to assess risk of developing ACs among the groups. Subgroup analysis was done to evaluate risk of ACs in patients receiving cytotoxic T-lymphocyte-associated protein 4 inhibitor (CTLA4i) versus program cell death protein 1 inhibitor (PD1i) and program death ligand 1 inhibitor (PDL1i) inhibitors and combination treatment (CT) …

Use Of Multi-Modal Non-Contrast Mri To Predict Functional Outcomes After Stroke: A Study Using Dp-Pcasl, Dti, Noddi, And Map Mri, Julia Diamandi, Christian Raimondo, Keenan Piper, Joanna Roy, Stephanie Serva, Mahdi Alizadeh, Adam Flanders, Stavropoula Tjoumakaris, Michael Gooch, Pascal Jabbour, Robert Rosenwasswer, Nikolaos Mouchtouris

Department of Neurosurgery Faculty Papers

PURPOSE: This study aims to assess whether water exchange rate (k_w), a surrogate for blood-brain barrier (BBB) permeability, is associated with functional outcomes in patients with acute ischemic stroke (AIS).

METHODS: We studied 22 AIS patients enrolled from 1/2022 to 4/2024 who underwent multi-modal non-contrast imaging on a 3.0-Tesla scanner, including DP-pCASL, DTI, NODDI and MAP imaging. For each parametric map, the intensity and standard deviation (SD) were calculated for the infarcted region. The diffusion maps included were b0, Fractional Anisotropy (FA), Mean Diffusivity (MD), Intra-cellular Volume Fraction (ICVF), Free Water Fraction (FWF), and Orientation Dispersion Index (ODI), …

Co-Option Of Mitochondrial Nucleic Acid-Sensing Pathways By Hsv-1 Ul12.5 For Reactivation From Latent Infection, Patryk A. Krakowiak, Matthew E. Flores, Sean R. Cuddy, Abigail L. Whitford, Sara A. Dochnal, Aleksandra Babnis, Tsuyoshi Miyake, Marco Tigano, Daniel A. Engel, Anna R. Cliffe

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Although viruses subvert innate immune pathways for their replication, there is evidence they can also co-opt antiviral responses for their benefit. The ubiquitous human pathogen, Herpes simplex virus-1 (HSV-1), encodes a protein (UL12.5) that induces the release of mitochondrial nucleic acid into the cytosol, which activates immune-sensing pathways and reduces productive replication in nonneuronal cells. HSV-1 establishes latency in neurons and can reactivate to cause disease. We found that UL12.5 is required for HSV-1 reactivation in neurons and acts to directly promote viral lytic gene expression during initial exit from latency. Further, the direct activation of innate immune-sensing pathways triggered …

Transforming Diagnosis Through Artificial Intelligence

Faculty, Staff and Students Publications

Artificial intelligence (AI) is increasingly permeating the fabric of medicine, but getting full benefits will likely require fundamental changes in practice. Accepting this will be challenging for many clinicians. However, it may be necessary to ensure that AI’s ambitious promises translate into real-life improvement.

A Randomized, Placebo-Controlled, Cross-Over Trial Of Ketamine In Rett Syndrome, Elizabeth Berry-Kravis, Tim A Benke, Cary Fu, Alan Percy, Bernhard Suter, David Morris, Randall L Carpenter, Eric D Marsh, Jana Von Hehn

Faculty, Staff and Students Publications

BACKGROUND: Preclinical studies and anecdotal case reports support the potential therapeutic benefit of low-dose oral ketamine as a treatment of clinical symptoms in Rett syndrome (RTT); however, no controlled studies have been conducted in RTT to evaluate safety, tolerability and efficacy.

DESIGN: This was a sequentially initiated, dose-escalating cohort, placebo-controlled, double blind, randomized sequence, cross-over study of oral ketamine in 6-12-year-old girls with RTT to evaluate short-term safety and tolerability and explore efficacy.

METHODS: Participants were randomized to either five days treatment with oral ketamine or matched placebo, followed by a nine-day wash-out period and then crossed-over to the opposite …

Incorporating Visual Information Into Natural Language Processing, Maxwell Mbabilla Aladago

Dartmouth College Ph.D Dissertations

Natural language describes entities in the world, some real and some abstract. It is also common practice to complement human learning of natural language with visual cues. This is evident in the heavily graphical nature of children’s literature which underscores the importance of visual cues in language acquisition. Similarly, the notion of “visual learners” is well recognized, reflecting the understanding that visual signals such as illustrations, gestures, and depictions effectively supplement language. In machine learning, two primary paradigms have emerged for training systems involving natural language. The first paradigm encompasses setups where pre-training and downstream tasks are exclusively in natural …

Heartmate 3 Left Ventricular Assist Device Infection-Related Left Ventricular Pseudoaneurysm: Extirpation In The Setting Of Left Ventricular Recovery, Hari K. Rajagopal, Mark J. Zucker, J. Eduardo Rame, Louis E. Samuels, Keshava Rajagopal

Department of Surgery Faculty Papers

No abstract provided.

Large Negative Magnetoresistance In The Off-Stoichiometric Topological Semimetal Prsbxte2-X, Gokul Acharya, Krishna Pandey, M. M. Sharma, Jian Wang, Santosh Karki Chhetri, Md Rafique Un Nabi, Dinesh Upreti, Rabindra Basnet, Joshua Sakon, Jin Hu

Physics Faculty Publications and Presentations

Magnetic topological materials LnSbTe (Ln = lanthanide) have attracted intensive attention because of the presence of interplay between magnetism, topological, and electron correlations depending on the choices of magnetic Ln elements. Varying Sb and Te composition is an efficient approach to control structural, magnetic, and electronic properties. Here, we report on the composition-dependent properties in PrSbxTe2-x. We identified the tetragonal-to-orthorhombic structure transitions in this material system and very large negative magnetoresistance in the x = 0.3 composition, which might be ascribed to the coupling between magnetism and transport. Such unusual magnetotransport enables PrSbxTe2-x topological materials as a promising platform for …

Image Of Mathematics: A Case Study Of Two Women's Early Mathematics Experiences, Lili Zhou, Elizabeth Suazo-Flores, Bima Sapkota, Rose Mbewe, Jill Newton

School of Mathematical & Statistical Sciences Faculty Publications

People often view mathematics as abstract, cold, and irrelevant to real life, and their school experiences likely influence such views. In this case study, we investigated the mathematics experiences of two women who participated in an afterschool girls-only STEM club 30 years ago when they were in fifth and sixth grades. We explored how the participants' early in- and out-of-school experiences informed their images of mathematics. We collected data through a survey, focus group interviews, and individual interviews. We employed oral history methods in interviews to grant participants a significant degree of freedom to retrospectively recount and reconstruct their experiences. …

Identifying Cyberbullying Roles In Social Media, Manuel Sandoval, Mohammed Abuhamad, Patrick Furman, Mujtaba Nazari, Deborah Hall, Yasin N. Silva

Computer Science: Faculty Publications and Other Works

Social media has revolutionized communication, allowing people worldwide to connect and interact instantly. However, it has also led to increases in cyberbullying, which poses a significant threat to children and adolescents globally, affecting their mental health and well-being. It is critical to accurately detect the roles of individuals involved in cyberbullying incidents to effectively address the issue on a large scale. This study explores the use of machine learning models to detect the roles involved in cyberbullying interactions. After examining the AMiCA dataset and addressing class imbalance issues, we evaluate the performance of various models built with four underlying LLMs …

Insect Frass Fertilizer As Soil Amendment For Improved Forage And Soil Health In Circular Systems, Amanda J. Ashworth, Helen Carla S. Amorim, Gerson L. Drescher, Philip A. Moore, Maria Guadalupe Rojas, Juan Morales-Ramos, Ann M. Donoghue

Crop, Soil and Environmental Sciences Faculty Publications and Presentations

Insect farming is expected to increase in coming years, thus generating high quantities of frass (insect excreta). Frass valorization hinges on basic agronomic research prior to industry upscaling. Here, we investigated soil physiochemical properties, SMAF (Soil Management Assessment Framework) soil health, CO2 efflux, and bermudagrass [Cynodon dactylon (L.) Pers.] yield and quality as affected by yellow mealworm (Tenebrio molitor L.) frass [3400 and 6800 kg ha-1, low (LF) and high (HF) rates], poultry litter (PL; 3400 kg ha-1), and ammonium nitrate (AN; 67 kg N ha-1). HF increased soil C, N, P, K, and Mg by 10, 12, 44, 58, …

Joint Fluid Multi-Omics Improves Diagnostic Confidence During Evaluation Of Children With Presumed Septic Arthritis, Yolanda Peña-López, Naureen G Tareen, Bo Zhang, Indu Raman, Carlos A Arana, Yang Liu, Nicolai S C Van Oers, Simrat Morris, Lora V Hooper, Lawson A B Copley, Prithvi Raj

Faculty, Staff and Student Publications

Background: An accurate diagnosis of septic versus reactive or autoimmune arthritis remains clinically challenging. A multi-omics strategy comprising metagenomic and proteomic technologies were undertaken for children diagnosed with presumed septic arthritis to advance clinical diagnoses and care for affected individuals.

Methods: Twelve children with suspected septic arthritis were prospectively enrolled to compare standard of care tests with a rapid multi-omics approach. The multi-omics combined bacterial 16S rRNA metagenomics, single cell transcriptomics, and proteomics on knee joint fluid specimens. The diagnostic value of the multi-omics was ascertained relative to standard of care culture and PCR-negative results.

Results: Ten children with suspected …

Spatial Transcriptome Reveals Histology-Correlated Immune Signature Learnt By Deep Learning Attention Mechanism On H&E-Stained Images For Ovarian Cancer Prognosis, Chun Wai Ng, Kwong-Kwok Wong, Barrett C Lawson, Sammy Ferri-Borgogno, Samuel C Mok

Faculty, Staff and Student Publications

Background: The ability to predict the prognosis of patients with ovarian cancer can greatly improve disease management. However, the knowledge on the mechanism of the prediction is limited. We sought to deconvolute the attention feature learnt by a deep learning convolutional neural networks trained with whole-slide images (WSIs) of hematoxylin-and-eosin (H&E)-stained tumor samples using spatial transcriptomic data.

Methods: In this study, 773 WSIs of H&E-stained tumor sections from 335 patients with treatment naïve high-grade serous ovarian cancer who were included in The Cancer Genome Atlas (TCGA) Pan-Cancer study were used to train, and validate, and to test a ResNet101 CNN …

A Paper-Based Hpv E7 Oncoprotein Assay For Cervical Precancer Detection At The Point Of Care, Chelsey A Smith, Sai Paul, Karen E Haney, Sonia G Parra, Meaghan Bond, Leticia López, Mauricio Maza, Juan Felix, Preetha Ramalingam, Pablo Escobar, Philip E Castle, Kathleen M Schmeler, Rebecca R Richards-Kortum

Faculty, Staff and Student Publications

Cervical cancer, while preventable through screening and treatment of cervical precancer, remains a global challenge with a disproportionately high burden of disease in resource-limited settings, especially in low- and middle-income countries (LMICs). Lack of affordable, easy-to-use screening and diagnostic tests contributes to this disparity. Most commercially available tests are not appropriate for use in LMICs due to resource constraints. Specifically, HPV mRNA and oncoprotein tests that have high specificity for cervical precancer and cancer require complex sample preparation protocols and expensive instrumentation. To address these limitations, an HPV E7 oncoprotein assay for HPV16, 18, and 45 was developed that is …

The Quic-Sp: A Spanish Language Tool Assessing Unpredictability In Early Life Is Linked To Physical And Mental Health, Sabrina R. Liu, Natasha A. Bailey, Sara Romero-González, Amy Moors, Belinda Campos, Elysia P. Davis, Laura M. Glynn

Psychology Faculty Articles and Research

Accumulating evidence indicates that unpredictable signals in early life represent a unique form of adverse childhood experiences (ACEs) associated with disrupted neurodevelopmental trajectories in children and adolescents. The Questionnaire of Unpredictability in Childhood (QUIC) was developed to assess early life unpredictability, encompassing social, emotional, and physical unpredictability in a child’s environment, and has been validated in three independent cohorts. However, the importance of identifying ACEs in diverse populations, including non-English speaking groups, necessitates translation of the QUIC. The current study aims to translate and validate a Spanish language version of the QUIC (QUIC-SP) and assess its associations with mental and …

On Legislating Cybercrime: Nigerian, South African, And United Kingdom Perspectives, Sagwadi Mabunda, Roland Akindele

Communications of the IIMA

Cybercrime has evolved to be a menacing challenge to all the countries of the globe. Consequently, it has become necessary for effective laws and policies to be enacted and implemented globally. This paper aims to review the cybercrime legislation of three jurisdictions: Nigeria, South Africa, and the United Kingdom (UK), to examine how each country has conceptualised and legislated cybercrime. The paper begins with a discussion on the definitional considerations necessary for legislating cybercrime. It draws from the Council of Europe Convention on Cybercrime (Budapest Convention) as the primary international convention on cybercrimes, to analyse some of the specific provisions …

Augmenting Legal Expertise: The Role Of Ai In Enhancing Human Capabilities In Legal Services

Communications of the IIMA

This study explores the dynamics of digital transformation within the legal services

industry, focusing on the integration of artificial intelligence (AI) to augment

human capabilities. By examining the interplay between institutional norms and

technological innovations, this research aims to understand how AI disrupts

traditional legal practices while maintaining ethical standards and promoting

equitable access to justice. Employing a qualitative content analysis, this research

analyzes data from international news sources spanning April 2011 to March 2021.

The study examines the roles of key industry actors, identifies barriers to digital

adoption, and explores the implications of digitalization for competition within the

legal …

The Intricate Dance Between Stars And Words: A Review Of Customer Reviews In Tourism

Communications of the IIMA

Travel and tourism industries rely heavily on customer reviews from past travelers as an invaluable source for informing potential travelers’ decisions. Thanks to the internet, reviews are an invaluable source for both quantitative star ratings as well as qualitative text comments that evaluate travel experiences. In this paper we analyse this complex relationship between text comments and their associated star ratings; using existing literature we highlight their interplay to give an overall picture of customer satisfaction. Factors that influence ratings and comments include both intrinsic (service quality, staff behavior) and extrinsic aspects such as location or price. Sentiment analysis through …

A Translation Of John Gower's Cronica Tripertita, Robert J. Meindl, Mark T. Riley

Accessus

John Gower's account of the last years of Richard II presents an uncompromised condemnation of the king's reign.

Tug Of War Between Opt-In And Opt-Out Organ Donation Systems, Amna Cehaja

DePaul Journal of Health Care Law

The demand for organ transplants is far greater than the supply of transplantable organs. Every day, twenty people in the United States die as they await an organ transplant; this equates to roughly 7,300 people annually. Whilst organ donation can be highly effective for prospective patients, not all individuals want to take part in such an action. A person’s decision not to partake in organ donation can stem from their ethics, morality, religion, and much more. For individuals that live in the United States and do not want to donate their organs upon death, they do not have to take …

Overcoming Drone Noise For Effective Human Detection In Emergency Response, Patric Hruswicki, Isaiah Vahos, Hardi Patel

Student Research Symposium (SRS)

In disaster scenarios where visibility can be compromised, and conventional detection methods are ineffective, acoustic detection offers a critical means of localizing victims in search and rescue operations. However, the inherent noise generated by uncrewed aerial rotorcraft systems poses significant challenges to the effective use of acoustic sensing equipment. This research investigates the feasibility of utilizing drones equipped with high-sensitivity microphones to detect and locate humans in such environments. Key questions address the microphone sensitivity required for reliable identification of human sounds and the technologies available to mitigate propeller noise. Through a fusion of aeroacoustic improvements to be made to …

Adjusting Immunity For Unconstitutional Torts, Liam Grah

University of Chicago Legal Forum

Sovereign immunity protects the government from liability arising in suits brought against it by citizens. Though lacking a firm constitutional basis, sovereign immunity has been justified as protecting the public fisc and maintaining the sense of sovereign dignity. The Federal Tort Claims Act (FTCA) broadly waives sovereign immunity for tort claims against the United States. The discretionary function exception maintains immunity for tortious acts committed by employees acting within the valid bounds of their discretion. There is a circuit split about whether the discretionary function exception immunizes tortious conduct that is also unconstitutional. Circuits in the majority side of the …