Digital Commons Network^™

Comprehensive Data-Driven Analysis Of Nyc Real Estate Transactions: Insights Into Pricing Dynamics, Neighborhood Evolution, And Socioeconomic Influences, Ruiming Xu

Dissertations, Theses, and Capstone Projects

This project provides a comprehensive analysis of New York City’s real estate market, focusing on its historical evolution, shifting demographics, and the significant impact of the COVID-19 pandemic on housing trends. Utilizing data from trusted sources like Zillow, the NYC Department of Finance, and the U.S. Census Bureau, the study investigates how property values have changed over time, highlights neighborhoods undergoing notable transformations, and identifies the economic, cultural, and social factors driving these changes. The research aims to reveal the complex forces shaping the market while offering insights into its future direction and the reasons behind current trends. A key …

A Prototype Online Platform For Exploring Post-Covid Academic Recovery In U.S. Public Schools: An Example From California Public Schools, Nicole Baz

Dissertations, Theses, and Capstone Projects

This project introduces a prototype online platform designed to analyze the effects of the COVID-19 pandemic on academic achievement in public schools and districts across the United States. Leveraging data from the Stanford Education Data Archive (SEDA) and the National Center for Education Statistics (NCES), the platform enables users to examine recovery rates as measured by standardized test scores. California serves as a proof-of-concept case study, demonstrating the platform's ability to explore recovery patterns in Reading Language Arts and Mathematics between 2019 and 2023. The platform provides interactive data visualizations and dashboards that facilitate analyses based on district size, resources, …

Differential Mechanisms Of Access In Working Memory: Comparing Global And Selective Retrieval, Jade M. Turbides

Dissertations, Theses, and Capstone Projects

Working memory (WM) is essential for numerous cognitive tasks, yet the mechanisms underlying selective access to specific subsets of its contents vs. global, nonselective access remain incompletely understood. Context-specific selection of individual items from WM has been found to be more time-consuming and error-prone than globally accessing all memory contents. This study investigates whether the performance costs of selective WM access arise primarily from demands on item-context binding memory. Previous research has suggested that only selective access relies on memory for item-context bindings whereas global access can solely rely on item memory. Across two experiments, we employed task paradigms that …

The Effects Of Irrelevant Parameters In Language Acquisition, Yukun Zhang

Dissertations, Theses, and Capstone Projects

This paper investigates the effects of sententially irrelevant syntactic information on language acquisition models and introduces a new variant of the variational learner (VL) called the early decision variational learner (EDVL). EDVL accelerates convergence by locking in parameter values once they reach a threshold, in contrast to VL’s continued adjustments until all parameter values reach threshold. Both learners are grounded in the generative approach to language acquisition. We examine both learners' responses when they only update their parameter values when the input contain the relevant information to determin the parameter value such as prepositions, wh-words, and auxiliary verbs. Chapter 1 …

The Psychophysiology Of Primary And Secondary Variants Of Psychopathic Traits In Youth, Ines Guariguata

Dissertations, Theses, and Capstone Projects

Psychopathy is a cluster of personality traits marked by a pervasive callousness, lack of shame or remorse, deceitfulness, a persona of confidence and charm, shallow emotional connection, general lack of insight into their actions, and an absence of anxiety (Glenn & Raine, 2014; Hare, 2003). Research suggests that there are distinct etiological pathways to the development of psychopathic traits and that their responses to treatment are different (Craig et al., 2021; Yildrim & Derksen, 2015; Fleming et al., 2023). Primary variants show a low-fear, low-anxiety profile during stress, and have a genetic basis (Craig et al., 2021; Yildrim & Derksen, …

Banking And The Wider Economy: Essays On Capital And Cross-Border Risks, Morgan Hunt

Dissertations, Theses, and Capstone Projects

Chapter 1: This paper examines the impact of growth in the banking industry’s capital and assets on real output growth at both aggregate and industry levels using a short-run factor-augmented vector autoregression (FAVAR) model across 19 NAICS two-digit industries from 2007Q1 to 2019Q4. Results reveal that changes in capital growth significantly affect output growth in the Manufacturing and Finance industries, while changes in risk-weighted assets impact the Construction, Manufacturing, Real Estate, and Transportation industries. Conversely, output growth in the Manufacturing and Retail Trade industries influences capital growth, while Wholesale Trade output growth affects risk-weighted assets. These relationships are robust …

Advancing Structural And Textual Guidance In Medical Image Segmentation: A Journey From Fully Supervised To Weakly Supervised Learning, Jiaqi Yang

Dissertations, Theses, and Capstone Projects

Accurate segmentation of medical images is essential for clinical diagnosis, enabling precise measurement, monitoring, and analysis of anatomical structures. While advanced models have achieved impressive per-pixel performance under fully supervised settings, ensuring fine-scale structural completeness remains a challenge, particularly for complex biomedical structures where coherence and integrity are critical. Fully supervised methods also face inherent limitations due to their reliance on extensive pixel-level annotations. These annotations are labor-intensive, costly, and often suffer from low inter-expert agreement, especially in cases like OCT images where small lesions and unclear boundaries make precise labeling difficult. This underscores the challenge of acquiring large, high-quality …

Inherited Wounds: Generational Trauma In Postcolonial Film And Narrative Fiction Of The Global South, Sabrina Testi Melgarejo

Dissertations, Theses, and Capstone Projects

The theorization of trauma in literary studies emerged in the 1990s, evolving from its physiological origins to a multidisciplinary framework encompassing literature, psychology, and history. However, classical trauma theory, rooted in Western scholarship and focused on singular traumatic events, has been criticized for its limitations in addressing collective and ongoing trauma in non-Western contexts. This thesis responds to a call for a more inclusive approach to trauma studies, examining how multi-generational and cultural trauma is represented in non-Western postcolonial films and literature from the Global South, including works from the Philippines, Sri Lanka, Cuba, Angola, Mozambique, Vietnam, and Lebanon.

The …

Taming Biological Complexity Through The Use Of Symmetries, Luis A. Álvarez-García

Dissertations, Theses, and Capstone Projects

The study of biological systems is, inherently, the study of very complex systems. This is essentially due to the fact that they are made up of numerous, often very complicated, interactions between an extensive number of components. Often necessitating an abundance of quantitative parameters and details for a precise description. The human brain for ex- ample, consisting of ∼ 80 billion neurons with ∼ 800 to 100 trillion connections between them, each of them depending on a large set of parameters. Even simpler examples such as bacterial organisms, such as E. coli and B. subtilis, which we focus on …

Novel Alchemical Methodologies For Modeling Molecular Binding, Solmaz Azimi

Dissertations, Theses, and Capstone Projects

Molecular recognition is fundamental to all biological and biochemical processes. Understanding the interactions between molecules is the foundation for drug discovery and development, for understanding biological processes, and for the design of biosensors and nanomaterials. There is tremendous interest in the development of computer models to predict molecular association equilibria. In structure-based drug discovery enterprises, predicting the strength and selectivity of a small molecule to a biological target can advance target identification, aid ligand design, and accelerate high-throughput screening of drug compounds. This work focuses on free energy models, a class of computational methodologies grounded on the fundamental physical and …

Beauty Comes With A Price: But How Much Is It Worth It, Fabliha Afia

Dissertations, Theses, and Capstone Projects

The global skincare market, valued at 104.24 billion dollars in the year 2022, is very heterogeneous, ranging from prestige brands to more drugstore types. Even when the same key ingredients are present, the latter often sells for much higher due to branding and packaging and the aura of prestige created. This capstone project entitled "Beauty comes with a price: but how much is it worth?" investigates if such higher costs are justified due to superior quality or are driven by non-functional factors. It systematically compared the high-end versus drugstore skincare products in categories like sunscreens, serums, and exfoliants with respect …

Quantifying The Individual Bilingual Experience Through A Lens Of Language Dominance, Leeann Stover

Dissertations, Theses, and Capstone Projects

This article-based dissertation addresses some of the issues regarding the multifaceted nature of bi/multilingualism, focusing on the significance of individual variation in the measurement of language dominance. While age of later-acquired languages has traditionally been used to classify bilingual speakers into early and late bilinguals, the construct of language dominance has emerged as an additional criterion of classification. However, despite its utility in capturing dimensions of language experience beyond age of acquisition, the construct of language dominance has its own challenges of measurement and individual variation.

This dissertation focuses on two open-ended challenges in the quantification of language dominance: how …

Guaqueras And Campesinas In Western Boyacá, Colombia, María F. Buitrago

Dissertations, Theses, and Capstone Projects

Guaqueras and Campesinas in Western Boyacá (https://mariabuitsan.github.io/guaqueras-ycampesinas/) is a digital memory project chronicling the lives and labors of women residing in the emerald-producing municipalities of Colombia. The project explores women’s remarkable resilience amidst a historically extractive and patriarchal emerald economy by co-creating an online collection enriched with various sources such as interviews, photos of artifacts, and audio from fieldwork. The collection uses Dédalo, a free and open-source Cultural Heritage and Management System, to store, digitize, and index all the unedited material and presents a selection of these resources through a static website. The collection intends to illuminate and honor the …

Silver-Alloyed Cigs Thin-Film Solar Cells On Flexible Stainless-Steel Substrate, Zhi Huang

Dissertations, Theses, and Capstone Projects

Our dissertation demonstrates the optimization of ACIGS (Ag-Cu-In-Ga-Se) thin-film solar cells, achieving an efficiency of 20.4% through the combined effects of silver incorporation and alkali metal post-deposition treatment (PDT). The incorporation of 2.8% Ag into the CIGS lattice enhanced crystal quality, reduced disorder, and widened the bandgap by 0.103 eV, as evidenced by a significant reduction in Urbach energy. These improvements resulted in stronger light absorption, increased carrier generation, and enhanced photovoltaic parameters, including a short-circuit current density Jsc of 35.31 mA/cm², an open-circuit voltage Voc of 0.74 V, and a fill factor (FF) of 75.8%. PDT using rubidium fluoride …

China And Russia In Africa: The Case Of Togo, Eli J. Messanh

Dissertations, Theses, and Capstone Projects

This thesis examines the impacts of China and Russia’s influence in Africa and focuses on the case of Togo, looking into how the increase in China and Russia’s presence on the continent affects the latter, the similarities and differences of their engagements, and what Africans as well as Togolese think of the proliferation of China and Russia’s influence in their countries. Using a mixed-methods approach with discussions and in-depth literature reviews, the research concludes that China and Russia’s relations vis à vis African countries produce both positive and negative effects, however, the negative effects outweigh the positive. It is therefore …

Testing Toxicity: Two Approaches To Toxicity Detection, Nelson E. Jarrin

Dissertations, Theses, and Capstone Projects

The current online environment is increasingly being polluted by polarization, echo chambers, and a lack of constructive dialogue between individuals with differing viewpoints. Social media algorithms, while intended to personalize user experiences and marketing areas, have been heavily criticized for inadvertently amplifying extremist content and contributing to the spread of toxic commentary. The current state of the internet hinders productive conversations, fuels misinformation, entices disinformation and contributes to online and offline societal division. This is fueled by algorithms that can create echo chambers and by the anonymity given by online platforms. While tools like the Perspective API exist to identify …

Mid-Life Anti-Inflammatory Metabolites Are Inversely Associated With Long-Term Cardiovascular Disease Events, Anum Saeed, Chris Mckennan, Jiaxuan Duan, Yueh-Ning Yang, Kevin E Kip, David Finegold, Michael Vu, Justin Swanson, Oscar L Lopez, Ann Cohen, Mark Mapstone, Bing Yu, Christie M Ballantyne, Steven E Reis

Faculty, Staff and Student Publications

BACKGROUND: Preclinical data have shown that low levels of metabolites with anti-inflammatory properties may impact metabolic disease processes. However, the association between mid-life levels of such metabolites and long-term ASCVD risk is not known.

METHODS: We characterised the plasma metabolomic profile (1228 metabolites) of 1852 participants (58.1 ± 7.5 years old, 69.6% female, 43.6% self-identified as Black) enrolled in the Heart Strategies Concentrating on Risk Evaluation (Heart SCORE) study. Logistic regression was used to assess the impact of metabolite levels on ASCVD risk (nonfatal MI, revascularisation, and cardiac mortality). We additionally explored the effect of genetic variants neighbouring ASCVD-related genes …

Association Between Maternal Stress And Child Sleep Quality: A Nationwide Echo Prospective Cohort Study, Sarah Dee Geiger, Aruna Chandran, Marie L Churchill, Maxwell Mansolf, Cai Zhang, Salma Musaad, Courtney K Blackwell, Stephanie M Eick, Dana E Goin, Susan Korrick, Akram Alshawabkeh, Patricia A Brennan, Carrie V Breton, Jose F Cordero, Sean Deoni, Viren D'Sa, Anne L Dunlop, Amy J Elliott, Assiamira Ferrara, Arlene Keddie, Monique Lebourgeois, Kaja Z Lewinn, Daphne Koinis-Mitchell, Maristella Lucchini, Sara S Nozadi, Thomas O'Connor, Yeyi Zhu, Emily Zimmerman, Susan L Schantz

Children’s Nutrition Research Center Staff Publications

Background: Childhood sleep quality is associated with physical, cognitive, and behavioral health and predicts later sleep quality; it has many determinants, including developmental exposures.

Objectives: To examine associations between maternal stress during pregnancy and childhood sleep quality and determine whether postnatal stress mediates the association.

Method: Data from the Environmental Influences on Child Health Outcomes cohort were used. Perceived Stress Scale (PSS) T-scores were the exposure measure. Outcome measures were preschool Child Behavior Checklist (CBCL) sleep syndrome scale and Patient-Reported Outcomes Measurement Information System Sleep Disturbance Parent Proxy short form 4a (PSD4a) T-scores at ages 4-8 years. Linear mixed-effects regression …

Synaptic Alterations In Pyramidal Cells Following Genetic Manipulation Of Neuronal Excitability In Monkey Prefrontal Cortex, Guillermo Gonzalez-Burgos, Takeaki Miyamae, Yosuke Nishihata, Olga L Krimer, Kirsten Wade, Kenneth N Fish, Dominique Arion, Zhao-Lin Cai, Mingshan Xue, William R Stauffer, David A Lewis

Duncan NRI Faculty and Staff Publications

The primate dorsolateral prefrontal cortex (DLPFC) displays unique in vivo activity patterns, but how in vivo activity regulates DLPFC pyramidal neuron (PN) properties remains unclear. We assessed the effects of in vivo Kir2.1 overexpression, a genetic silencing tool, on synapses in monkey DLPFC PNs. We show for the first time that recombinant ion channel expression successfully modifies the excitability of primate cortex neurons, producing effects on synaptic properties apparently different from those in the rodent cortex.

Figg At 5: An Update On Us Public Perspectives On Forensic Investigative Genetic Genealogy Five Years After Its Introduction To Criminal Investigations, Christi J Guerrini, Jill O Robinson, Mohamed I Elsaid, Whitney Bash Brooks, Ariel Levchenko, Stephanie M Fullerton, Sara Huston, Norah L Crossnohere, John F P Bridges, Jacklyn M Dahlquist, Louiza Kalokairinou, Diana Madden, Cece Moore, Amy L Mcguire

Center for Medical Ethics and Health Policy Staff Publications

In 2018, after law enforcement announced it had used a technique called forensic investigative genetic genealogy (FIGG) to identify the Golden State Killer, we conducted a U.S. general population survey and found most respondents supported using FIGG to solve violent crimes. Since then, FIGG has helped close hundreds of criminal cases, but it also has weathered controversies. On FIGG's fifth anniversary, we conducted an expanded, follow-up survey with U.S.-based participants to determine if public opinion had changed and found continued support for FIGG across most applications. The same proportion (91 %) of respondents in the 2018 and 2023 surveys endorsed …

Improving Individualized Rhabdomyosarcoma Prognosis Predictions Using Somatic Molecular Biomarkers, Mark Zobeck, Javed Khan, Rajkumar Venkatramani, M Fatih Okcu, Michael E Scheurer, Philip J Lupo

Center for Medical Ethics and Health Policy Staff Publications

Purpose: Molecular markers increasingly influence risk-stratified treatment selection for pediatric rhabdomyosarcoma (RMS). This study aims to integrate molecular and clinical data to produce individualized prognosis predictions that can further improve treatment selection.

Methods: Clinical variables and somatic mutation data for 20 genes from 641 patients with RMS in the United Kingdom and the United States were used to develop three Cox proportional hazard models for predicting event-free survival (EFS). The Baseline Clinical (BC) model included treatment location, age, fusion status, and risk group. The Gene Enhanced 2 (GE2) model added TP53 and MYOD1 mutations to the BC predictors. The Gene …

Longitudinal Phage-Bacteria Dynamics In The Early Life Gut Microbiome, Michael J Tisza, Richard E Lloyd, Kristi Hoffman, Daniel P Smith, Marian Rewers, Sara J Javornik Cregeen, Joseph F Petrosino

Center for Medical Ethics and Health Policy Staff Publications

Microbial colonization of the human gut occurs soon after birth, proceeds through well-studied phases and is affected by lifestyle and other factors. Less is known about phage community dynamics during infant gut colonization due to small study sizes, an inability to leverage large databases and a lack of appropriate bioinformatics tools. Here we reanalysed whole microbial community shotgun sequencing data of 12,262 longitudinal samples from 887 children from four countries across four years of life as part of the The Environmental Determinants of Diabetes in the Young (TEDDY) study. We developed an extensive metagenome-assembled genome catalogue using the Marker-MAGu pipeline, …

Revisiting What Constitutes A Neglected Tropical Disease?, Paul J Brindley, Peter J Hotez, Shaden Kamhawi

Center for Medical Ethics and Health Policy Staff Publications

PLOS Neglected Tropical Diseases (PLOS NTDs) publishes research devoted to pathogenesis and other clinical aspects, epidemiology, prevention, diagnosis, treatment, and control of the neglected tropical diseases (NTDs), as well as work relevant to public health policy. We define NTDs as poverty-promoting infectious diseases that can negatively impact the quality of life in rural areas and poor urban areas of low- and middle-income countries but which can also affect specific communities within high-income countries. The poverty-inducing effects of the NTDs operate by impairing child health and development, pregnancy outcomes for both mother and child, worker productivity, and quality of life. The …

Ethical Governance For Genomic Data Science In The Cloud, Vasiliki Rahimzadeh, Sarah C Nelson, Adrian Thorogood, Jonathan Lawson, Stephanie M Fullerton

Center for Medical Ethics and Health Policy Staff Publications

Cloud platforms offer distinct advantages, but questions remain about how to ethically and efficiently manage human genomic data in the cloud. Data governance needs to be adapted to ensure transparency and security for research participants, as well as equitable and sustainable access for researchers.

Resilience And Coping: A Qualitative Analysis Of Cognitive And Behavioral Factors In Adults With Osteogenesis Imperfecta, Hannah E Cho, Whitney S Shepherd, Gianna M Colombo, Andrew D Wiese, W Conor Rork, Kristin M Kostick, Dianne Nguyen, Members Of The Bbdc, Chaya N Murali, Marie-Eve Robinson, Sophie C Schneider, Justin H Qian, Brendan Lee, V Reid Sutton, Eric A Storch

Center for Medical Ethics and Health Policy Staff Publications

Purpose: The aim of this qualitative study was to investigate resilience among adults with Osteogenesis Imperfecta (OI).

Materials and methods: Semi-structured interviews were conducted with 15 adults with OI. Transcripts were coded and subsequently abstracted, yielding themes specific to resilience and coping. Interview guides covered broad topics including pain challenges specific to OI, mental health issues related to OI, and priorities for future interventions for individuals with OI.

Results: Participants described resilience in the context of OI as the ability to grow from adversity, adapt to challenges resulting from OI-related injuries, and find identities apart from their condition. Psychological coping …

Predictors Of Bi-Directional Transitions From Mild Cognitive Impairment In A Diverse Cohort, Mitzi M. Gonzales, Roman Fernandez, Sarah Kremen, Zaldy S. Tan, Amy E. Werry, Xueqiu Jian, John Hart, Donald Royall, Gladys Maestre, Sara Espinoza

School of Medicine Publications

Trajectories following a diagnosis of mild cognitive impairment (MCI) are varied and may fluctuate over time. Among diverse ethnic and racial groups, social factors, medical comorbidities, and biases in assessment procedures may contribute to greater heterogeneity in the MCI diagnostic category and affect its prognostic significance for dementia. The study goal was to evaluate the frequency and variables associated with MCI transitions among non-Hispanic White (NHW) and Latinx older adults. Multistate Markov models characterized transitions across diagnostic states (cognitively unimpaired (CU), MCI, dementia) over ten years. Variables associated with transitions were assessed using hazard ratios (HR) and 95% confidence intervals …

Black English For Lawyers: A Primer, L. Alexander Walker Iii

Faculty Scholarship

Lawyers do not know as much about Black English as they should, and people’s freedom hangs in the balance. Differences between language varieties in sounds and grammar can change and have changed the outcome of cases: “He at work” and “He be at work” mean two completely different things. To reduce misinterpretation and therefore wrongful outcomes, this Article provides a primer on the sounds, words, grammar, and social context of Black English targeted directly at legal practitioners. It begins by explaining key concepts in linguistics and making the case for why lawyers must foreground accurate description over normative prescription when …

Simulation-Based Models For Postearthquake Response: A Survey And Research Directions, Abhijit Gosavi, Lauryn A. Spearing, Lesley H. Sneed

Engineering Management and Systems Engineering Faculty Research & Creative Works

Computer simulation is increasingly being used by emergency planners as a tool to improve disaster response given that it can model real-world scenarios, such as earthquakes. Although there has been an increase in simulation research focused on disaster response, much of this literature is from disparate fields and across disaster scenarios. To bridge this gap, this paper surveys simulation-based models for post-earthquake response from the year 2000 onward. Advantages of simulation over closed-form statistical models are discussed. Three main subproblems in post-earthquake response models are explored: (1) service distribution (e.g., food, water), (2) infrastructure restoration (at the building and transportation …

The Common Law Of Constitutional Conventions, David E. Pozen

Faculty Scholarship

Professor Jill Lepore’s Jorde Symposium lecture paints a rich portrait of state constitutional conventions as engines of democratization during the 1800s and issues a dire warning about the United States’ ongoing amendment drought. Citing their unfamiliarity, however, Lepore declines to consider federal constitutional conventions as a possible corrective. In this response Essay, I argue: first, that Lepore’s marginalization of Article V’s convention mechanism is in tension with her own historical and normative account; second, that while Lepore’s wariness of conventions is entirely understandable given the state of our politics — and entirely commonplace among progressives — it carries significant risks …

Research On Wireless Monitoring System For Internal Temperature Field Of Coal Gangue Mountain, Xiaofei Liu, Chunhao Liang, Jifa Qian, Xiaolin Li, Xuemei Li, Baoli Li, Guang Xu, Bin Zhou

Mining Engineering Faculty Research & Creative Works

In the long-term accumulation process, coal gangue can lead to severe consequences such as spontaneous combustion and explosions due to external factors. Additionally, the coal gangue that ignites spontaneously significantly pollutes the land and groundwater, causing serious risks to the health and safety of individuals living and working in the vicinity. Therefore, to mitigate the risk of spontaneous combustion resulting from the long-term accumulation of coal gangue, a monitoring system based on LoRa wireless communication technology is proposed to collect and monitor the internal temperature of coal gangue mountains in real time. In the laboratory, active temperature rise monitoring was …