Digital Commons Network^™

Aperiodic (1/F) Neural Activity Robustly Tracks Symptom Severity Changes In Treatment-Resistant Depression, Carl Hacker, Madaline M Mocchi, Jiayang Xiao, Brian Metzger, Joshua Adkinson, Bailey Pascuzzi, Raissa Mathura, Denise Oswalt, Andrew Watrous, Eleonora Bartoli, Anusha Allawala, Victoria Pirtle, Xiaoxu Fan, Isabel Danstrom, Ben Shofty, Garrett Banks, Yue Zhang, Michelle Armenta-Salas, Koorosh Mirpour, Nicole Provenza, Sanjay Mathew, Jeffrey F Cohn, David Borton, Wayne Goodman, Nader Pouratian, Sameer Anil Sheth, Kelly R Bijanki

Faculty, Staff and Students Publications

Background: A reliable physiological biomarker for major depressive disorder is essential for developing and optimizing neuromodulatory treatment paradigms. In this study, we investigated a passive electrophysiologic biomarker that tracks changes in depressive symptom severity on the order of minutes to hours.

Methods: We analyzed brief recordings from intracranial electrodes implanted deep in the brain during a clinical trial of deep brain stimulation for treatment-resistant depression in 5 human participants (nfemale = 3, nmale = 2). This surgical setting allowed for precise temporal and spatial sensitivity in the ventromedial prefrontal cortex, a challenging area to measure. We focused on the aperiodic …

Five-Year Outcomes Of Lenadogene Nolparvovec Gene Therapy In Leber Hereditary Optic Neuropathy, Patrick Yu-Wai-Man, Nancy Newman, Valérie Biousse, Valerio Carelli, Mark Moster, Catherine Vignal-Clermont, Thomas Klopstock, Alfredo Sadun, Robert C Sergott, Rabih Hage, Simona Degli Esposti, Chiara La Morgia, Claudia Priglinger, Rustum Karanja, Magali Taiel, José-Alain Sahel

Department of Neurology Faculty Papers

IMPORTANCE: Limited studies have assessed the long-term benefit/risk of gene therapy for Leber hereditary optic neuropathy (LHON).

OBJECTIVE: To determine the safety and efficacy of lenadogene nolparvovec in patients with LHON due to the MT-ND4 gene variant for up to 5 years after administration.

DESIGN, SETTING, AND PARTICIPANTS: The RESCUE and REVERSE Long-Term Follow-up Study (RESTORE), conducted from 2018 to 2022, is the 5-year follow-up study of the 2 phase 3 clinical studies RESCUE (Efficacy Study of Lenadogene Nolparvovec for the Treatment of Vision Loss Up to 6 Months From Onset in LHON Due to the MT-ND4 Mutation) and REVERSE …

Pancreatic Cancer Extracellular Vesicles Stimulate Schwann Cell Activation And Perineural Invasion In Vitro Via Il-8/Ccl2, Emory Gregory, Isabel Powers, Azemat Jamshidi-Parsian, Robert J. Griffin, Younghye Song

Biomedical Engineering Faculty Publications and Presentations

Purpose Pancreatic ductal adenocarcinoma (PDAC) remains a leading cause of cancer-related deaths, and perineural invasion (PNI), in which cancer cells infiltrate nerves, enables metastasis in most patients. PNI is largely attributed to Schwann cells (SC) that, when activated, accelerate cancer cell migration towards nerves. However, this cancer-associated reprogramming is generally under-appreciated. Additionally, tumor extracellular vesicle (EV) facilitation of cancer aggravation is well documented, but more investigation is required to better understand their role in PNI. Here, we assessed whether PDAC EVs mediate PNI via SC activation using tissue-engineered in vitro platforms and PANC-1 and HPNE human cell lines as models. …

Human-Ai Synergy In Survey Development: Implications From Large Language Models In Business And Research, Ping Fan Ke, Ka Chung Ng

Research Collection School Of Computing and Information Systems

This study examines the novel integration of Large Language Models (LLMs) into the survey development process in business and research through the development and evaluation of the Behavioral Research ASSistant (BRASS) Bot. We first analyzed the traditional scale development process to identify tasks suitable for LLM integration, including both human-in-the-loop and automated LLM data collection methods. Following this analysis, we developed the details of BRASS Bot, incorporating design principles of falsifiability and reproducibility. We then conducted a comprehensive evaluation of the BRASS Bot across a diverse set of LLMs, including GPT, Claude, Gemini, and Llama, to assess its usability, validity, …

The Role Of Surprisal In Issue Trackers, James Caddy, Christoph Treude, Markus Wagner, Earl T. Barr

Research Collection School Of Computing and Information Systems

Context: Software development creates and relies on a large volume of information, yet the volume of this information can make it challenging for developers to maintain an overview of all goings-on that a team and external actors contribute to a project. We posit that unexpected or “surprising” events could serve as important signposts amidst this information overload. These unexpected events may indicate underlying anomalies or emergent situations that require immediate attention. To explore this premise, our study leverages the concept of ‘surprisal’ from information theory to identify and quantify these unusual occurrences from the issues and pull requests of popular …

Wf-Ppg: A Wrist-Finger Dual-Channel Dataset For Studying The Impact Of Contact Pressure On Ppg Morphology, Matthew Yiwen Ho, Hung Manh Pham, Aaqib Saeed, Dong Ma

Research Collection School Of Computing and Information Systems

Photoplethysmography (PPG) is a simple optical technique widely used in wearable devices for continuous cardiac health monitoring. However, the quality of PPG signals, particularly their morphology, is influenced by the contact pressure between the skin and the sensor. This variability in signal quality complicates complex tasks that rely on high-quality signals, such as blood pressure and heart rate variability estimation, making them less reliable or even impossible. To address this issue, we present a novel dataset (termed WF-PPG) comprising PPG signals from the wrist measured under varying contact pressures, along with high-quality PPG signals from the fingertip captured simultaneously. Data …

Density Boosts Everything: A One-Stop Strategy For Improving Performance, Robustness, And Sustainability Of Malware Detectors, Jianwen Tian, Wei Kong, Debin Gao, Tong Wang, Taotao Gu, Kefan Qiu, Zhi Wang, Xiaohui Kuang

Research Collection School Of Computing and Information Systems

In the contemporary landscape of cybersecurity, AI-driven detectors have emerged as pivotal in the realm of malware detection. However, existing AI-driven detectors encounter a myriad of challenges, including poisoning attacks, evasion attacks, and concept drift, which stem from the inherent characteristics of AI methodologies. While numerous solutions have been proposed to address these issues, they often concentrate on isolated problems, neglecting the broader implications for other facets of malware detection. This paper diverges from the conventional approach by not targeting a singular issue but instead identifying one of the fundamental causes of these challenges, sparsity. Sparsity refers to a scenario …

Learning An Interpretable Stylized Subspace For 3d-Aware Animatable Artforms, Chenxi Zheng, Bangzhen Liu, Xuemiao Xu, Huaidong Zhang, Shengfeng He

Research Collection School Of Computing and Information Systems

Throughout history, static paintings have captivated viewers within display frames, yet the possibility of making these masterpieces vividly interactive remains intriguing. This research paper introduces 3DArtmator, a novel approach that aims to represent artforms in a highly interpretable stylized space, enabling 3D-aware animatable reconstruction and editing. Our rationale is to transfer the interpretability and 3D controllability of the latent space in a 3D-aware GAN to a stylized sub-space of a customized GAN, revitalizing the original artforms. To this end, the proposed two-stage optimization framework of 3DArtmator begins with discovering an anchor in the original latent space that accurately mimics the …

Procalcitonin-Guided Duration Of Antibiotic Treatment In Children Hospitalised With Confirmed Or Suspected Bacterial Infection In The Uk (Batch): A Pragmatic, Multicentre, Open-Label, Two-Arm, Individually Randomised, Controlled Trial, Cherry-Ann Waldron, Philip Pallmann, Simon Schoenbuchner, Debbie Harris, Lucy Brookes-Howell, Céu Mateus, Jolanta Bernatoniene, Katrina Cathie, Saul N. Faust, Helen Nabwera

Centre of Excellence in Women and Child Health

Background Procalcitonin is a rapid response biomarker specific for bacterial infection, which is not routinely used in the UK National Health Service. We aimed to assess whether using a procalcitonin-guided algorithm would safely reduce the duration of antibiotic therapy compared with usual care, in which C-reactive protein is the commonly used biomarker.

Methods The BATCH trial was a pragmatic, multicentre, open-label, parallel, two-arm, individually randomised, controlled trial conducted in 15 hospitals in England and Wales. Children aged 72 h to 18 years who were admitted to hospital and were being treated with intravenous antibiotics for suspected or confirmed bacterial infection …

A Commitment Rule For Insolvency Forum, Anthony J. Casey, Aurelio Gurrea-Martinez, Robert K. Rasmussen

Research Collection Yong Pung How School Of Law

In this Article, we propose a new rule for determining the proper forum for insolvency proceedings. Currently, the Model Law on Cross-Border Insolvency (Model Law)—promulgated by the United Nations Commission on International Trade Law (UNCITRAL)—looks to a debtor’s center of main interest (COMI) to determine the proper forum for a foreign main insolvency proceeding. This rule is flawed. It is both inflexible and manipulable. It is also indeterminate and neither requires nor allows advance commitment by debtors. As a result, it leads to uncertainty, increases litigation costs, and opens the door to opportunistic manipulation by debtors. These costs, in turn, …

Negotiating With Gpt-4: Digital Doormat Or Skilful Counterpart?, Dorcas Quek Anderson

Research Collection Yong Pung How School Of Law

Large language models (LLMs) such as GPT-4 have been creatively harnessed in the conflict resolution arena as dialogue agents interacting with humans within negotiations, due to their capacity for in-context learning and giving human-like responses. In light of the burgeoning use of LLMs in conflict resolution training, a pilot study was conducted to ascertain the desirability of using dialogue agents built on GPT-4 in conducting simulations for students learning negotiation skills. This article discusses insights gained from the study on the reliability of LLM agents in following prompts for negotiation simulations; notable negotiation behaviour of the LLM agent; the degree …

Teacher Retention And The Future Of Learning: Alarming Concerns About Preparing The Next Generation Of Citizens, Dejuanna M. Parker, Barbara D. Holmes

Journal of Research Initiatives

Research is robust in detailing the various reasons teachers leave the profession. There is scant literature on why teachers stay and what should be done to improve teacher retention. Teacher retention is a primary concern nationally and internationally. The inability to retain teachers has resulted in a teacher shortage and significantly affects student learning. Sorenson and Ladd (2020) This study yielded three emergent themes related to integral factors of teacher retention: changing attitudes on administrative support, workplace collegiality, and persistence of passion and purpose. Recommendations offered include encouraging administrators to leverage the passion and commitment of the educators to create …

Factors Influencing Jordanian College Understudies' Impressions Of Learning Through Emergency Distance Learning (Edl), Abdelnaser Sanad Alakayleh

Journal of Research Initiatives

In this study, which used a quantitative and correlational approach, the variables influencing Jordanian university students' perceptions of their education under emergency remote learning scenarios were investigated. An online survey was administered to a sample of 765 male and female education stage students. Jordan offers higher education for both genders and at different levels in different regions. Many criteria connected to perceived learning were taken into consideration when administering the study questionnaire. It was discovered that the economics students had a more positive perception of learning than the education and science students, followed by deep learning, avoiding superficial learning factors, …

An Investigation Of Ninth Grade Students’ Perceptions Of Equitable Grading Practices, Sarah Ruth Morris, Sarah C. Mckenzie, Jonathan Wai, Robert Anthony Maranto

Journal of Research Initiatives

This study investigated students’ perceptions of grading equity practices, focusing on preferences and the influence of student characteristics on support for grading equity. Through surveys and open-ended questions involving 256 ninth-grade students, the research highlighted a general preference for fair and supportive grading systems that consider individual circumstances and offer retake opportunities. Multivariate OLS regression analysis reveals that while Pre-AP students show resistance, students experiencing high-stress levels favor equitable grading practices. The findings suggest the need for educational reforms prioritizing transparency and fairness, including student voices in policy development, and emphasizing grading systems that support holistic student development.

Advisor Satisfaction To Support Online Student Retention, Erica K. Whiddon

Electronic Theses and Dissertations

In this dissertation, the researcher explored the relationship between satisfaction with academic advising and online student retention. Online student retention is a critical issue in the context of increasing competition for students in higher education institutions. The specific problem was that online students have lower retention rates, and the reasons students typically select online degree programs are also the reasons they drop out of their degree programs. The purpose was to identify whether students’ reported satisfaction with their advisors mediated the relationship between the existence of external personal life factors and retention. A quantitative nonexperimental causal-comparative and correlational research design …

Improving Outcomes Of Depression Through Implementation Of Depression Screenings At A College Health Center, Shelby Leigh Hanigan

Electronic Theses and Dissertations

Depression is a common phenomenon. Depression and suicidality are a problem on university campuses. This quality improvement Doctor of Nursing project aimed to establish the importance of routine depression screenings within a college health clinic. The purpose of this project was to determine if implementing routine depression screenings at a university health clinic will or will not increase the number of counseling referrals when compared to the absence of depression screenings in place within an identified timeframe. This protocol screened for depression in college-aged students and suggested care to those students who screened positive. It also led an interprofessional team …

The Impact Of Vacations On Urban Women's Well-Being From The Perspective Of Feminist Urbanism, Jie Gao, Deborah Kerstetter, Tianfu Wang

Faculty Research, Scholarly, and Creative Activity

Vacations are known to foster well-being outcomes, yet few researchers have accounted for the influence of individual attributes such as gender, residential setting, or cultural context. As a result, there is a noticeable gap in the well-being literature concerning well-being outcomes for female travelers whose subjectivities have been shaped in as well as by their residential environment (urban) and culture. Using qualitative inquiry informed by the feminist urbanism perspective, this study uncovered urban Chinese women's cognitive representations of well-being outcomes from vacations. Findings revealed that vacations provide liberation from cultural constraints, boosting of social bonds and relationship building, enabling reflection …

What Happened When I Took Calculus For The First Time At Age 47, Britt Kaufmann

Journal of Humanistic Mathematics

These five poems are inspired by being in high school math classes and could be used in the classroom for cross-curricular enrichment.

The Operator Algebras Mentor Network: Impact Of Community-Based Mentoring, Anna Duwenig, Kari Eifler, Priyanga Ganesan, Lara Ismert, Viviana Meschitti, Sarah Plosker, Karen Strung

Journal of Humanistic Mathematics

The Operator Algebras Mentor Network (OAMN) is an international mentoring initiative that offers support in small groups to women and minority genders in the particularly male-dominated field of operator algebras (OA) in mathematics. Expected advantages of membership include raising awareness of the lack of gender diversity in this field, providing advice to mentees by mentors (e.g., pertaining to career or work/life balance), broadening one’s network in OA, etc. In this project, we set out to determine if membership within the OAMN is beneficial to its members. To this end we sent a questionnaire to OAMN members and a control group …

White Horses In The Sky: Or The Magical Place Where Topology Meets Poetry, Sanziana Caraman, Lorelei Caraman

Journal of Humanistic Mathematics

What do Shakespearean words, doughnuts, cups of tea, and horses in the sky all have in common with a famous theorem? To discover the answer, we take you on a journey in a strange, enchanted land: the land where mathematics meets poetry. Here we explore how a fundamental literary trope, metaphor, and a fundamental result in topology, Brouver's Fixed Point Theorem, touch and illuminate one another. Delving into the symmetry of this transdisciplinary embrace, we find that it reveals, not only the beauty of poetry and mathematics, but that of life itself: the beauty hidden in ordinary things like a …

On The Development Of Equations In Ancient China, Wanwan Huang

Journal of Humanistic Mathematics

This article explores the evolution of equations in ancient China, detailing the development process through the presentation of various classical mathematics problems spanning four stages. We present these problems and their solutions, both using ancient Chinese terminology and modern language. With this work, we hope to offer an insightful examination of the achievements and limitations of ancient Chinese mathematicians in their work on equations, particularly in relation to culture, practical needs, and human creativity.

Teaching Mathematics For Labour Emancipation: An Autoethnography Of A Math Teacher In Mykonos, Dimitris T. Maris, Konstantinos P. Christou

Journal of Humanistic Mathematics

A wealthy society does not necessarily ensure a good education for its students, just as it does not guarantee wealth for its workers. In this paper we visit a junior high school mathematics classroom on the Greek island of Mykonos, where a significant number of students are employed. In this context, we explore how a mathematics teacher, inspired by social justice mathematics, can empower students in their work environments. We adopt an autoethnographic approach in our narrative, presenting the process of designing and implementing specific mathematical activities aimed at revealing the issue of labour exploitation in the touristic Greek islands. …

Prompting Progress: Authorship In The Age Of Ai, Edward Lee

Florida Law Review

This Article examines a question of profound importance today: do the works people create using artificial intelligence (AI) qualify for copyright? This Article explains why the Copyright Office’s 2023 guidance excluding AI-generated works from copyright is wrong. The Office’s newfound requirement of the so-called “traditional elements of authorship”—including sufficient control, avoidance of random elements in the creative process, prediction of the final work ahead of time, and dictation of the specific results—finds no support in the text, history, or structure of the Progress Clause, Supreme Court precedent, or the Copyright Act, past or present. It limits “Authors” to “traditional elements” …

Complete Diversity: The Origin Story, Mark Moller

Florida Law Review

The complete diversity rule is among the most criticized rules in the law of federal jurisdiction. The product of Chief Justice John Marshall’s cryptic decision in Strawbridge v. Curtiss, the rule vests federal diversity jurisdiction only if all adverse parties on a complaint are citizens of different states. Complete diversity protects states’ control of state-law litigation. Yet, the rule is also hard to square with the diversity statutes’ text. As a result, federal jurisdiction mavens have condemned the complete diversity rule as a Marshall invention “out of whole cloth.” This Article offers new historical evidence that proves the critics …

Making Things Worse, Failing To Make Things Better, Dov Waisman

Florida Law Review

This Article presents the first extensive analysis of a question in American tort law that has remained unresolved for nearly a century. When someone voluntarily attempts to protect another person from a pre-existing, independent risk of harm, should they be held liable for negligently failing to make the situation better or should they be held liable only if they negligently make the situation worse? Different courts have answered this question differently. Noting the absence of a clear pattern in the case law, the Second and Third Restatements of Torts both decline to take a definitive position on the issue. I …

Theatre As Exigency: A Case For Live Performance From The Ghosts Of The Theatre, Erin J. Schmidt

Theatre, Dance & Film Faculty Publications

No abstract provided.

Building A Global Partnership Through A Shared History, Lisa Lacross, Shawn Dillard, Bri Ard, Kern Jackson

International Journal of Transformative Teaching and Learning in Higher Education

Effective global partnerships in higher education promote intercultural awareness (Delong et al., 2011) and influence future study and work abroad experiences by articulating the value of global learning (Lewin, 2009). Seeking to broaden global engagement opportunities for minoritized students, specifically African Americans, one institution developed a virtual exchange program through a global partnership of stakeholders from Ghana, Togo, Benin, Cape Verde, and the United States. Grounded in a shared history of the 2019 discovery of the last reported ship to bring enslaved West Africans to the United States, students from Mobile, Alabama and Cotonou, Benin participated in virtual discussions that …

Responding To Technology-Induced Transformations In Writing Education: Conceptualizing And Teaching The Literacies Of Privacy, Originality, And Agency, Shyam Sharma

International Journal of Transformative Teaching and Learning in Higher Education

This article explores the transformative impact of technological advancements—especially computers, the internet, and artificial intelligence (AI)—on writing and literacy education. Building on relevant scholarships, it argues that there is an urgent need to update traditional literacy education by adding/extending three additional literacies: the literacies of privacy, originality, and agency. Reconceptualizing privacy, originality, and agency in relation to the reshaping of literacy by emerging technologies in the past few decades, as the article shows, would help advance pedagogies to address the disruption to fundamentals that are worth preserving and building upon. The article addresses the challenges posed by the increasingly public …

Oh076 Lucil Wilson Oral History, David Sullivan

Land Between the Lakes

Lucil Wilson discusses the educational system in the Land Between the Lakes region in Kentucky at both the elementary and secondary levels. She describes attending a one room school as a child and compares that experience with other educational institutions throughout her teaching career. She recalls the schools at Cadiz, Kentucky and the qualification requirements needed for a teacher's certificate in the early 1940s. She reflects upon her school work and activities, along with her goals and responsibilities as an educator. Wilson concludes by describing her husband's general store, purchasing store items on credit, bartering and local hucksters.

Oh068 Beulah Ryan Oral History (2), Sammy Fisk

Land Between the Lakes

Beulah Ryan discusses life on the farm in the Land Between the Lakes region of Kentucky. Her recollections go back to the turn of the 20th Century. She describes her childhood, Saturday and Sunday worship services, and her salvation experiences. She also recalls the organization of the Golden Pond Baptist Church in Trigg County and Hopewell Baptist Church in Lyon County.