Digital Commons Network^™

Protein Arginine Methyltransferases As Regulators Of Cellular Stress, Julia Zaccarelli-Magalhães, Cristiane Teresinha Citadin, Julia Langman, Drew James Smith, Luiz Henrique Matuguma, Hung Wen Lin, Mariana Sayuri Berto Udo

Faculty, Staff and Student Publications

Arginine modification can be a "switch" to regulate DNA transcription and a post-translational modification via methylation of a variety of cellular targets involved in signal transduction, gene transcription, DNA repair, and mRNA alterations. This consequently can turn downstream biological effectors "on" and "off". Arginine methylation is catalyzed by protein arginine methyltransferases (PRMTs 1-9) in both the nucleus and cytoplasm, and is thought to be involved in many disease processes. However, PRMTs have not been well-documented in the brain and their function as it relates to metabolism, circulation, functional learning and memory are understudied. In this review, we provide a comprehensive …

Management Of Isolated Partial Acl Tears: A Survey Of International Acl Surgeons, Christopher S Frey, Kinsley J Pierre, Nicole S Pham, Geoffrey D Abrams, Seth L Sherman, Tim Spalding, Marc R Safran

Faculty, Staff and Student Publications

Background: Partial anterior cruciate ligament (ACL) tears, particularly injuries detected with magnetic resonance imaging (MRI) but stable on ligamentous examination, appear to be recognized more frequently; however, there remains no consensus management for this complex pathology.

Purpose: To present the results of a survey of a group of international ACL experts on the management of partial ACL injuries.

Study design: Survey study; Level of evidence, 5.

Methods: The ACL Study Group is an international group of orthopaedic surgeons with a special interest in the ACL. There are 169 members overall, with 135 clinically active surgeons. A branching logic survey was …

Deformity Considerations In Cervical Laminoplasty: A Narrative Review, Joseph P Drain, Paul Alvarez, William Ryan Spiker, Elizabeth Yu

Faculty, Staff and Student Publications

Objectives: We discuss the incidence of postoperative kyphosis following laminoplasty and its impact on outcomes, as well as critical radiographic parameters, intraoperative technical factors, and postoperative protocols that can be used to improve results.

Summary of background data: When appropriately selected, cervical laminoplasty is a motion-sparing treatment option for cervical myelopathy and is a valid alternative to laminectomy and fusion procedures. However, like other posterior-based cervical decompression techniques, laminoplasty can cause postoperative kyphosis.

Methods: A PubMed search was performed to gather articles that focus on cervical deformity in the context of cervical laminoplasty.

Results: The reported conversion rates of lordotic …

Non-Invasive Prenatal Screening: Testing Motivations And Decision Making In The Low-Risk Population, Jenna K Lea, Blair K Stevens, Shannon Mulligan, Syed S Hashmi, Rebecca Lunstroth, Meagan G Choates

Faculty, Staff and Student Publications

Non-invasive prenatal screening provides a risk assessment for aneuploidies by utilizing cell-free DNA (cfDNA). It is recommended that cell-free DNA screening (cfDNA screening) be offered to all pregnant people regardless of a priori risk for aneuploidy. In the absence of an increased risk, alternative motives for electing cfDNA screening and different levels of informed decision making may arise. Therefore, our study aimed to characterize low-risk patients' motivations for cfDNA screening election, determine how often informed decisions are being made, and compare motivations between informed and uninformed decision makers. A survey that included a modified, validated measure of informed choice (MMIC) …

Applications Of Metabolomics And Lipidomics In The Neonatal Intensive Care Unit, Jonathan D Reiss, Samson J Mataraso, Lindsay F Holzapfel, Ivana Marić, Maya M Kasowski, Camilia R Martin, Jonathan Z Long, David K Stevenson, Gary M Shaw

Faculty, Staff and Student Publications

The metabolome and lipidome comprise the thousands of molecular compounds in an organism. Molecular compounds consist of the upstream metabolic components of intracellular reactions or the byproducts of cellular pathways. Molecular and biochemical perturbations are associated with disorders in newborns and infants. The diagnosis of inborn errors of metabolism has relied on targeted metabolomics for several decades. Newer approaches offer the potential to identify novel biomarkers for common diseases of the newborn and infant. They may also elucidate novel predictive or diagnostic measures for a variety of health trajectories. Here, we review the relevance of the metabolome and lipidome for …

Acquired Hepatocerebral Degeneration In A Septic Patient: Hospital Course And Mri Findings, Ethan L Porter, Alexandria R Koney, Alexia R Jauregui, Emelie N Mcquitty, Courtney T Huynh, Rita B Khouri, Alisha Kashyap, Matthew T Wong

Faculty, Staff and Student Publications

Acquired hepatocerebral degeneration (AHD) is a rare neuropsychiatric disorder affecting cirrhotic patients, often presenting with neuropsychiatric symptoms triggered by a precipitating factor. Magnetic resonance imaging (MRI) showing T1 hyperintensities in the globus pallidus is diagnostic. In this case report, a 40-year-old female patient with alcoholic cirrhosis presented with generalized swelling, jaundice, fever, and signs of septic shock. After stabilization, changes in cognition while this patient was hospitalized prompted the management of several different factors, including the underlying infection, hypernatremia, vitamin deficiency, alcohol withdrawal, and hyperammonemia. Infectious disease consultation helped determine the antibiotic selection and dosage for bacteremia and later concerns …

Pharmacologic Management Of Heart Failure With Preserved Ejection Fraction (Hfpef) In Older Adults, Ashkan Hashemi, Min Ji Kwak, Parag Goyal

Faculty, Staff and Student Publications

There are several pharmacologic agents that have been touted as guideline-directed medical therapy for heart failure with preserved ejection fraction (HFpEF). However, it is important to recognize that older adults with HFpEF also contend with an increased risk for adverse effects from medications due to age-related changes in pharmacokinetics and pharmacodynamics of medications, as well as the concurrence of geriatric conditions such as polypharmacy and frailty. With this review, we discuss the underlying evidence for the benefits of various treatments in HFpEF and incorporate key considerations for older adults, a subpopulation that may be at higher risk for adverse drug …

Exploring Unintended Consequences From The Prospective Payment System Transitional Drug Add-On Payment Adjustment To Refine Program Enhancement Strategies, Donald Andrew Molony, Dia Rose Waguespack

Faculty, Staff and Student Publications

No abstract provided.

Respiratory Outcomes Of Infants Born Extremely Preterm In The Necrotizing Enterocolitis Surgery Trial, Sara B Demauro, Erik A Jensen, Scott A Mcdonald, Susan Hintz, Jon Tyson, David K Stevenson, Martin L Blakely

Faculty, Staff and Student Publications

The multicenter Necrotizing Enterocolitis Surgery Trial compared initial peritoneal drainage with laparotomy among infants with extremely low birth weight and surgical necrotizing enterocolitis or intestinal perforation. In this post hoc analysis of trial data, initial drainage was associated with adverse respiratory outcomes, both in hospital and through 2 years corrected age.

Protocol For A Field Trial Of A Hearing And Vision Support Intervention For People Living In Long-Term Care In Australia, Carly Meyer, Najwan El-Saifi, Naomi Rose, Kasia Bail, Colette Browning, Dayna Cenin, Antonio Ahumada-Canale, Megan Campbell, Tim England, Melanie Ferguson, Yuanyuan Gu, Reema Harrison, Chyrisse Heine, Lisa Keay, Sheela Kumaran, Iracema Leroi, Gerald Liew, Angelita Martini, Ralph Martins, John Newall, Smriti Raichand, Emma Scanlan, Hamid R. Sohrabi, Melinda Toomey, Johanna Westbrook, Piers Dawes

Research outputs 2022 to 2026

Introduction: Hearing and vision impairments are prevalent among residents in long-term care settings. Hearing and vision impairments frequently go unsupported, affecting residents' quality of life and healthcare costs. This paper describes the protocol for a pre−post evaluation and process evaluation of a pragmatic sensory support intervention (SSI) that was developed with residents, informal caregivers and long-term care workers. Methods and Analysis: A prospective pre−post-intervention trial within long-term care will be conducted, including three groups: residents (n = 87), informal caregivers (n = 87) and long-term care workers (n = 40). Outcome measures include health-related quality of life and well-being measures …

Case Studies In Heritable Vascular Disease: Proceedings Of The Uthealth Houston Multidisciplinary Aortic Conference, Milan Jaiswal, Lucas Ribe, Rana O Afifi, Yuki Ikeno, Alana C Cecchi, Bihong Zhao, Akiko Tanaka, Gustavo S Oderich, L Maximilian Buja, Dianna M Milewicz, Siddharth K Prakash, Anthony L Estrera

Faculty, Staff and Student Publications

Heritable thoracic aortic disease is caused by dominantly inherited mutations in more than a dozen genes, including TGFB2 mutations that cause Loeys-Dietz syndrome. McGovern Medical School at UTHealth Houston convenes a regular conference that includes cardiothoracic and vascular surgeons, cardiologists, geneticists, radiologists, and pathologists to formulate multidisciplinary approaches for the management of complex heritable thoracic aortic disease cases. In this report, we highlight the unique management of individuals with distinct presentations of Loeys-Dietz syndrome owing to TGFB2 mutations.

Blind And Low-Vision Students As Surveyors Of In/Accessibility In Technology-Mediated Formal Education, Natalie Shaheen

Faculty Publications - College of Education

K-12 institutions are slowly realizing (a) that many of the instructional technologies they use are inaccessible and (b) that technical debt oppresses blind and low-vision (BLV) students. Herein, I report the findings from a qualitative exploration of how BLV students differentiate between accessible and inaccessible technology-mediated education. The findings suggest that in/accessible technology-mediated education is an assemblage of learning, access labor, teachers, technologies, temporalities, and affectivities. I argue that to construct technology-mediated education that is equitable and accessible to BLV students K-12 institutions must do more than pay off their technical debt. I conclude with recommendations for how K-12 institutions …

'When The State Looks At You': Administering Whiteness Through Surveillance, Affect, And Efficiency In Elementary Literacy Teaching, Michael J. Young

Faculty Publications - College of Education

Elementary literacy education policy continues to centre intensified use of standardised testing in the early elementary grades across the United States. The increase of datafication in schooling works to establish a surveillance system in schools. Including analysis through the lenses of Foucauldian disciplinary power and critical whiteness studies, this qualitative article examines teacher narratives from five white elementary literacy teachers. Through these narratives, these teachers share their lived experiences in navigating school reforms involving increased datafication. Findings highlight the affective technologies and colonial discursive constructions white teachers employed through this surveillance and how literacy and literacy teaching were shaped through …

Consolidating The Evidence On The Effectiveness Of Strategies To Promote Vegetable Intake In Priority Settings: An Overview Of Systematic Reviews, Paige G. Brooker, Astrid A.M. Poelman, Katherine M. Livingstone, Clare E. Collins, Seema Mihrshahi, Ros Sambell, Jason H.Y. Wu, Gilly A. Hendrie

Research outputs 2022 to 2026

Background: Effective interventions to increase vegetable intake are urgently needed. This systematic rapid review aimed to summarise the effectiveness of interventions targeting increased vegetable intakes across diverse settings. Methodology: The review was guided by the conduct of rapid reviews from the Cochrane Handbook. The literature was searched in February 2024 across PubMed, Web of Science and Cochrane Central for systematic review articles published since 2014. The Risk of Bias In Systematic Reviews tool was used and characteristics of reviews synthesised narratively with intervention effectiveness results were summarised. Results: A total of 20 systematic reviews met the eligibility criteria. Most targeted …

Patient And Family Involvement In Nursing Bedside Handover: A Qualitative Descriptive Study Of Consumer Perceptions Of Nursing Care, Manonita Ghosh, Beverly O’Connell, Hien Thi Nguyen, Linda Coventry, Amanda Towell-Barnard, Olivia Gallagher, Karen Gullick, Lucy Gent, Rosemary Saunders

Research outputs 2022 to 2026

Background/Objectives: Patient and family involvement in bedside handover is a requirement of the national standards on patient safety and quality in Australia. To ensure patient-and-family-centred care, it is essential to understand how patients and families perceive their involvement in nursing bedside handover and what difficulties they face when participating. This study aimed to explore patient and family perceptions of their involvement in nursing bedside handover. Methods: We employed a qualitative descriptive study design with in-depth and semi-structured interviews. Using purposive and convenience sampling, 24 patients and family members were recruited from two adult hospitals in Western Australia between November 2021 …

Patients' Perception Of Missed Nursing Care In A Tertiary Hospital: A Cross-Sectional Study, Afia Achiaa Sarpong, Amanda Towell-Barnard, Lucy Gent, Ebenezer Afrifa-Yamoah, Diana Arabiat

Research outputs 2022 to 2026

AIMS: To identify types of patient-reported missed nursing care and adverse events and identify the factor associated with missed care in a Western Australian tertiary hospital. BACKGROUND: Research in the domain of missed nursing care has established the association between missed nursing care and unsafe patient outcomes. However, there is a paucity of evidence on patient perception of missed nursing care and associated factors. DESIGN: Cross-sectional study. METHOD: A study of inpatients in a tertiary teaching hospital in Western Australia was carried out. Ninety-eight patients admitted in 16 medical and surgical wards were sampled. The patient MISSCARE survey was used …

Trajectories Of Supportive Care Needs For People Who Travel To Receive Cancer Treatment: A Longitudinal Study In Australia, Susannah K. Ayre, Elizabeth A. Johnston, Michael Ireland, Sonja March, Jeff Dunn, Suzanne Chambers, Belinda C. Goodwin

Research outputs 2022 to 2026

Objective: To describe trajectories of change in unmet supportive care needs over a two-year period among people diagnosed with cancer and assess whether these trajectories vary as a function of sociodemographic and clinical characteristics. Methods: This analysis used data from a longitudinal study of people in Queensland, Australia who travelled largely from regional and remote areas to metropolitan centres to receive cancer care (N = 784). Supportive care needs were measured at baseline, then at 3-, 12-, and 24-month post-baseline across five domains (‘psychological’, ‘physical and daily living’, ‘health systems and information’, ‘patient care and support’, ‘sexuality’) using the Supportive …

A Living Feminist Postdevelopmental Lexicon For Early Education, Mindy Blaise, Veronica Pacini-Ketchabaw

Research outputs 2022 to 2026

Expanding the important body of work that addresses child development’s limitations and responding to the ecological crisis that threatens the future of life on Earth, this article proposes a living feminist postdevelopmental lexicon. The lexicon introduces 26 concepts that together challenge the theory/practice divide, disrupt Cartesian modes of subjectivity, reorient taken-for-granted ideas as problematic in early education, open up early education to inquiries that respond to the political and ethical questions of our milieu, and generate conditions for creative, inventive, thoughtful, and ethical projects. The paper invites readers to engage with and creatively add to the lexicon, making it an …

Effects Of Applicants' Use Of Generative Ai In Personnel Selection: Towards A More Nuanced View?, Filip Lievens, Patrick D. Dunlop

Research Collection Lee Kong Chian School Of Business

Generative AI (GenAI) has made rapid inroads in assessment, as a growing number of applicants rely on it as a coach in unproctored assessments of various selection procedures. This had led to assertions that applicants' GenAI use undermines key assumptions of the predictive model underlying selection and is thus disruptive for organizations' current unproctored assessments, thereby invoking various strategies of organizations to deter and detect its use. In this provocation article, we present a more nuanced view. To this end, we start by reviewing the recent research related to the effects of applicants' use of GenAI in assessment and discuss …

Looking Out For Danger: Theoretical And Empirical Issues In Translating Human Attention Bias Tasks To Assess Animal Affective States, Sarah Kappel, Sarah Collins, Michael Mendl, Carole Fureix

School of Biological and Marine Sciences

Understanding animal emotional (affective) state is highly relevant to various disciplines (e.g., animal welfare, neuroscience, comparative psychology), and has been significantly advanced by translating affect-induced cognitive bias paradigms rooted in human psychology to non-human animal studies. Attention bias (i.e., preferential attention allocation, AB) tests are increasingly used as more practical substitutes to commonly used judgement bias tests. Yet, evidence that AB reflects affective valence in animals is still limited. We review in-depth the concept of attention and AB described in humans and discuss utilising human-derived AB paradigms for measuring animal affective states. We describe key concepts and functions of attention …

How Managers ‘Make Meaning’ Of Business Tournament Rituals, David Sarpong, Shadrack Asante, Christopher Agyapong Siaw, Nicholas O'Regan, Derrick Boakye

Plymouth Business School

In this paper, we examine how managers ‘make meaning’ of business tournament rituals (BTRs)— recognition-based contests in which participating firms get social endorsements and winners receive prestigious awards. In exploring two UK BTRs, we found that managerial orienting systems, made up of beliefs about the identity of their firm, competitors, and customers, and what it takes to compete in their environments, drive managers to compete in BTRs. Their interpretive view of BTRs as sources of strategic capabilities and hard market power, we argue, is constructed, and projected to the viewing public through a set of four distinct but ‘durationally indivisible’ …

Parental Emotional, Social And Transitional Health In The First 6 Months After Childhood Critical Illness: A Longitudinal Qualitative Study, Pei Fen Poh, Matthew C. Carey, Joseph C. Manning, Jan Hau Lee, Jos M. Latour

School of Nursing and Midwifery

Aim: To explore the experiences and support needs of parents in the first 6 months after paediatric critical care. Design: Longitudinal qualitative design. Methods: Sequential semi-structured qualitative interviews were conducted with a sample of 28 parents in succession at 1 month and at 6 months (n = 22) after their child's discharge from paediatric critical care using purposive sampling. Data were analysed using the adapted five-stage framework analysis. Results: Data were developed into eight synthesized themes, three domains and an overarching theme: Regaining Normalcy. Families of children requiring medical treatment at 6 months showed signs of adaption to daily care …

Information Spillover And Corporate Policies: The Case Of Listed Options, Gennaro Bernile, Jianfeng Hu, Guangzhong Li, Roni Michaely

Research Collection Lee Kong Chian School Of Business

Information production associated with derivatives markets is not a sideshow; rather, it has significantly positive spillover effects on an array of corporate decisions of underlying firms. Using a regression-discontinuity design based on exogenous variation in options availability as an instrument for changes in the information environment, we show that options introductions have causal effects on corporate policies on both sides of the balance sheet. Through improved information efficiency, options availability reduces the need for debt and payout, increases efficient investment, and yields superior innovation. We conduct two independent experiments demonstrating that our instrument s impact is not derived from alternative …

Consumption Responses To Income Shocks Through Lottery Winning, Seonghoon Kim, Kanghyock Koh

Research Collection School Of Economics

We study the effects of lottery winning on consumption spending using newly available household survey data in Singapore. We find strong consumption responses to a transitory income shock via lottery wins. Lottery winners spend about half of their prizes within 12 months of winning. We show that consumption responses are stronger among households with more binding liquidity constraints and less risk aversion, which is consistent with the standard life-cycle model. The strong consumption response suggests that fiscal stimulus policies or other public transfer programs could be an effective means of boosting consumption spending of the economy in the short run.

Something In The Air: Does Air Pollution Affect Fund Managers’ Carbon Divestment?, Thanh Huynh, Frank Weikai Li, Ying Xia

Research Collection Lee Kong Chian School Of Business

We examine whether fund managers overestimate carbon risk when they are exposed to local air pollution. We find that air pollution causes managers to underweight stocks of high-emission firms. The effects are stronger for less salient scopes of carbon emissions, among managers located in pro-environmental states, and among those likely to be surprised by air pollution—consistent with the idea that managers revise their beliefs about climate-transition risk following their exposure to air pollution. Carbon-intensive stocks sold by managers who are exposed to air pollution subsequently outperform stocks that they buy, suggesting that such underweighting is costly to fund investors.

It's Just A Game! Effects Of Fantasy In A Storified Test On Applicant Reactions, Marie L. Ohlms, Klaus G. Melchers, Filip Lievens

Research Collection Lee Kong Chian School Of Business

There is increasing attention to storification of assessments (i.e., embedding a storyline into a non-storified assessment) in research and practice and to gamified and game-based assessment in general. However, there is a surprising lack of agreement and of recommendations regarding what level of fantasy of the storyline one should choose for the storification from the perspective of applicant reactions. A distinction is typically made between fantasy (e.g., fighting aliens) and realistic (e.g., workday simulations) storylines, with both choices having their advantages and disadvantages. In this study, a sample of 195 participants was shown either a storified realistic test, a storified …

A Head-To-Head Comparison Of Situational Judgment Tests And Assessment Centers For Measuring And Predicting The Same Performance Dimensions, Iman Shakeri, Filip Lievens

Research Collection Lee Kong Chian School Of Business

To date, a limited set of studies have compared the criterion-related validity of low-fidelity (SJT) versus high-fidelity (AC) simulations for predicting job performance. Unfortunately, these studies validated these simulations through the overall assessment rating (OAR) instead of on the basis of specific dimensions. Given SJTs and ACs were compared that measured different dimensions, our understanding of the relative and comparative validity of these assessment approaches in measuring the same set of dimensions is still limited. Therefore, this study aims to conduct a head-to-head comparison of the criterion-related validity of the AC and the SJT (and their incremental validity) while keeping …

Retirement And Organizations: Advocating Organizational Responsibility For Retirement In Practice And Scholarship, Valerie Caines, Gokhan Ertug, Prashant Bordia, Deidra J. Schleicher

Research Collection Lee Kong Chian School Of Business

In this editorial we discuss organizations’ role in the process of retirement. We argue that organizations have abdicated their moral obligation to older workers, thereby negatively impacting older workers’ wellbeing and their successful transition to retirement. We also note that organizational studies scholars have not paid adequate attention to that negligence, or its alternatives. We suggest that, among other reasons, this oversight can be a result of the comparatively privileged socioeconomic positions of faculty in business schools vis-à-vis older workers in many other occupations, as well as to a discord between traditional human capital and human resource management theories and …

The Boundaries Of The Law: Can Us Private Enforcement Discipline Foreign Firms?, Massimo Massa, Xiaoqiao Wang, Bohui Zhang, Hong Zhang

Research Collection Lee Kong Chian School Of Business

Existing studies tend to focus on how a legal system reinforces the efficiency of its domestic firms or foreign companies that are subject to its domestic jurisdiction (e.g., via cross-listing). Our study provides critical normative implications in the era of financial globalization by showing that the influence of a country’s legal institutions extend beyond its territorial boundaries. We examine whether US shareholder-initiated class action lawsuits can discipline non-US firms. Using an international sample of firms over the period 1994–2019, we find that a US class action lawsuit against a non-US firm cross-listed in the US negatively affects the value of …

Coevolution Of Soes And The Chinese Economy: The Roles Of Soe Heterogeneity From The Institutional, Strategic, And Organizational Perspectives, Kenneth G. Huang, Runtian Jing, Jun Xia, Man Zhang, Weiguo Zhong, David Zhu

Research Collection Lee Kong Chian School Of Business

State-owned enterprises (SOEs) in China play a critical role in national economic development and the country's positioning on the global stage. Chinese SOEs have undergone substantial transformations from traditional government-run entities to a variety of corporate forms exhibiting different levels of state involvement. Despite their substantial influence, the internal diversity of SOEs – from wholly state-owned to mixed-ownership – has not been thoroughly examined. This paper provides an overview of SOEs' critical roles in the Chinese economy, the relationship between SOEs and privately owned enterprises (POEs), and the challenges of SOEs in different stages of Chinese economic development. It then …