Engineered Immunomodulatory Extracellular Vesicles From Epithelial Cells With The Capacity For Stimulation Of Innate And Adaptive Immunity In Cancer And Autoimmunity, Xin Luo, Fernanda G Kugeratski, Dara P Dowlatshahi, Hikaru Sugimoto, Kent A Arian, Yibo Fan, Li Huang, Danielle Wills, Sergio Lilla, Kelly Hodge, Sara R Zanivan, Valerie S Lebleu, Kathleen M Mcandrews, Raghu Kalluri

Faculty, Staff and Student Publications

Extracellular vesicles (EVs) are generated by all cells. Systemic administration of allogenic EVs derived from epithelial and mesenchymal cells have been shown to be safe, despite carrying an array of functional molecules, including thousands of proteins. To address whether epithelial cells derived EVs can be modified to acquire the capacity to induce immune response, we engineered 293T EVs to harbor the immunomodulatory molecules CD80, OX40L and PD-L1. We demonstrated abundant levels of these proteins on the engineered cells and EVs. Functionally, the engineered EVs efficiently elicited positive and negative co-stimulation of human and murine T cells. In the setting of …

Intensive Lifestyle Intervention, Cardiac Biomarkers, And Cardiovascular Outcomes In Diabetes: Look Ahead Cardiac Biomarker Ancillary Study, Kershaw V Patel, Zainali Chunawala, Subodh Verma, Matthew W Segar, Katelyn R Garcia, Chiadi E Ndumele, Thomas J Wang, James L Januzzi, Antoni Bayes-Genis, Javed Butler, Carolyn S P Lam, Christie M Ballantyne, James A De Lemos, Alain G Bertoni, Mark Espeland, Ambarish Pandey

Faculty, Staff and Students Publications

Background: N-terminal pro-B-type natriuretic peptide (NT-proBNP) and high-sensitivity cardiac troponin T (hs-cTnT) are associated with cardiovascular outcomes and are recommended for measurement in type 2 diabetes (T2D). However, the effects of an intensive lifestyle intervention (ILI) targeting weight loss on cardiac biomarkers and the prognostic association of changes in these biomarkers with risk of adverse cardiovascular outcomes in T2D are not well-established.

Objectives: This study sought to evaluate the effects of an ILI on cardiac biomarkers and the association of changes in cardiac biomarkers with risk of cardiovascular outcomes in T2D.

Methods: Participants of the Look AHEAD (Action for Health …

Author Correction: Orthogonal And Multiplexable Genetic Perturbations With An Engineered Prime Editor And A Diverse Rna Array, Qichen Yuan, Hongzhi Zeng, Tyler C Daniel, Qingzhuo Liu, Yongjie Yang, Emmanuel C Osikpa, Qiaochu Yang, Advaith Peddi, Liliana M Abramson, Boyang Zhang, Yong Xu, Xue Gao

Faculty, Staff and Students Publications

Correction to: Nature Communications 10.1038/s41467-024-55134-9, published online 30 December 2024

In the version of the article initially published, there were errors in Fig. 3d, where in the x-axis labels now reading “GPP-shRNA1, GPP-shRNA2, GPP-shRNA3…,” the second and third labels were duplicates of the first. The figure is amended in the HTML and PDF versions of the article.

Otolaryngology Practitioner Attitudes Toward Human Papillomavirus Vaccination In Academic Otolaryngology Clinics, Dante J. Merlino, Katelyn S. Rourk, George B. Sankar, Adam J. Luginbuhl, Brian J. Boyce, Michelle M. Chen, Eric M. Dowling, Michael C. Topf, Raymond L. Chai, Karthik Rajasekaran, Eric J. Moore, Daniel L. Price, George Saieed, Kathryn M. Van Abel

Department of Otolaryngology - Head and Neck Surgery Faculty Papers

Despite the existence of a highly effective and safe vaccine against human papillomavirus (HPV) infection, vaccination rates remain low. The most prevalent HPV-associated malignancy in the United States is oropharyngeal cancer, but otolaryngology practitioners do not offer the HPV vaccine, and their feelings around offering HPV vaccination have not been evaluated. A 43-question survey, including a twelve-question knowledge quiz, was sent to otolaryngology practitioners at seven academic institutions. Twelve questions comprised a knowledge quiz testing practitioner understanding of HPV, while the remainder of the questions evaluated comfort with and likelihood of recommending vaccination. Of the 442 practitioners who were sent …

Mexiletine Dosing And Tolerability In Refractory Chronic Migraine: Insights From Post-Lidocaine Infusion Treatment, Lucia Liao, Hsiangkuo Yuan, Dylan Selbst, Emily Casaletto, Jiangang Liao, Clinton Lauritsen

Department of Neurology Faculty Papers

Background: Mexiletine is used as a preventive medication for refractory chronic migraine (rCM) and to prolong migraine improvement following intravenous lidocaine infusion. However, published evidence supporting its use in migraine remains limited. This retrospective study describes the dosing, treatment duration, and adverse effects of mexiletine in a group of patients with rCM following lidocaine infusion. Methods: Electronic medical records were reviewed at the Jefferson Headache Center. Baseline pain intensity and monthly headache days were collected at baseline and up to 6 office visits within 1-year post-discharge. The duration of mexiletine treatment was evaluated for up to 40 months post-discharge. Results: …

Assessing Dynamic Cognitive Function In The Daily Lives Of Youths With And Without Type 1 Diabetes: Usability Study, Mary Katherine Ray, Jorie Fleming, Andrew Aschenbrenner, Jason Hassenstab, Brooke Redwine, Carissa Burns, Ana Maria Arbelaez, Mary Ellen Vajravelu, Tamara Hershey

2020-Current year OA Pubs

BACKGROUND: Studies have shown a relationship between worse glycemic control and lower cognitive scores in youths with type 1 diabetes (T1D). However, most studies assess long-term glucose control (eg, years-decades) and cognition at a single time point. Understanding this relationship at a higher temporal resolution (eg, minutes-hours) and in naturalistic settings has potential clinical implications. Newer technology (eg, continuous glucose monitoring [CGM] and ecological momentary assessment) provides a unique opportunity to explore the glucose dynamics that influence dynamic cognition; that is, cognitive functions that fluctuate short-term and are influenced by environmental factors.

OBJECTIVE: Before we can assess this relationship, we …

Trends In Osteopathic Medical Education: A Scoping Review, Katie Hoskins, Molly Montgomery, Abbey Griffith, Hannah Pollard, Debra Orr-Roderick, Darell Schmick, Jeanne Strausman, Sarah Wade, Melinda Robertson, Megan Dearmond

Faculty and Staff Publications

Context: Following the transition to a single graduate medical education (GME) accreditation system in 2020, leaders at American Association of Colleges of Osteopathic Medicine (AACOM) were interested in learning more about the research being done about osteopathic medical education leading up to that point in time.

Objectives: The objective of this scoping review was to identify trends in undergraduate and graduate osteopathic medical education and to determine where this information was being disseminated and the institutions who were creating the content.

Methods: Searches were conducted in eight databases: PubMed (National Center for Biotechnology Information [NCBI]), MEDLINE (Ovid), Embase (Elsevier), Cumulative …

Mbnl Overexpression Rescues Cardiac Phenotypes In A Myotonic Dystrophy Type 1 Heart Mouse Model, Rong-Chi Hu, Yi Zhang, Larissa Nitschke, Sara J Johnson, Ayrea E Hurley, William R Lagor, Zheng Xia, Thomas A Cooper

Faculty, Staff and Students Publications

Myotonic dystrophy type 1 (DM1) is an autosomal dominant disease caused by a CTG repeat expansion in the dystrophia myotonica protein kinase (DMPK) gene. The expanded CUG repeat RNA (CUGexp RNA) transcribed from the mutant allele sequesters the muscleblind-like (MBNL) family of RNA-binding proteins, causing their loss of function and disrupting regulated pre-mRNA processing. We used a DM1 heart mouse model that inducibly expresses CUGexp RNA to test the contribution of MBNL loss to DM1 cardiac abnormalities and explored MBNL restoration as a potential therapy. AAV9-mediated overexpression of MBNL1 and/or MBNL2 significantly rescued DM1 cardiac phenotypes including conduction delays, contractile …

Newe Shalom And Tarum: Two Intermediate Bronze Age Sites In The Judaean Shephelah, Benyamin Storchan

Qadum: Journal of Excavation Reports from Israel

Two salvage excavations were conducted at Newe Shalom and Tarum in the Judean Shephelah. The excavations revealed architectural remains indicating the existence of two settlements dating to the Intermediate Bronze Age. At Newe Shalom, a complete multiroom structure was uncovered. The absence of additional architectural remains in the vicinity indicates that it functioned as an isolated structure. At Tarum, the remains of a single structure were uncovered. These structures share common characteristics and fit well within the general architectural, ceramic and flint repertoire of the Intermediate Bronze Age in the region.

Investigating The Effects Of Resveratrol On Opioid-Induced Hyperalgesia, Bryana Cox, Thien Do, Ashlyn Hughes, Zane Kingsbury, Keara Leroy, Andrew J. Payne

Annual Research Symposium

Opioid-induced hyperalgesia (OIH) is an adverse effect of chronic opioid therapy, characterized by increased sensitivity to pain. This study will seek to determine if using resveratrol supplementation as an indirect enhancer to increase the expression of the KCC2 membrane transporter can alleviate the symptoms of OIH in human subjects.

Amplifying Indigenous Wellbeing: ‘Imi Pono Survey Development And Validation, Brandon C. Ledward, Wendy Kekahio, Pālama Lee, Katherine Tibbetts, Carla Hostetter, Lisa Watkins-Victorino, Trudy Cherasaro, Steven Tedeschi, Carrie Germeroth

Journal of Indigenous Research

The growth of indigenous research methodologies and calls for data sovereignty are reshaping the discourse around evidence-based policymaking. This article summarizes the development and validation of the ‘Imi Pono Hawai‘i Wellbeing Survey, which examines wellbeing from indigenous, holistic, and strengths-based perspectives. The survey is anchored to a Kanaka Maoli (Native Hawaiian) model of wellbeing created through a community-participatory process involving diverse stakeholders. Early results show Native Hawaiians to be major contributors to Hawai‘i’s wellbeing, consistently reporting higher rates than non-Hawaiians for civic engagement, family relationships, and spirituality, as well as connections to culture, ‘āina, and community. This project informs strategic …

The Opportunities And Barriers Surrounding The Use Of Digital Health And Telemedicine In Sub-Saharan Africa, Aveline Langmead, Afua Osei-Wusu, Erica Tutuwan, Sara Mcmahon, Porter Biggs

Annual Research Symposium

No abstract provided.

Staff Attitude, Library Policies And Service Delivery In University Libraries In Ogun State, Nigeria, Ilori Edeole Maria Mrs, Owolabi Ruth O Dr, Oden Abigail N. Mrs, Ogungbade Aderonke A. Mrs

Library Philosophy and Practice (e-journal)

University library services aim to meet the information needs of the university community, fostering learning and research. Quality service, particularly in tangible aspects and reliability, leads to user satisfaction. Staff attitude significantly impacts library service utilization, as does library policy, which guides library operations. The study adopted survey research design. The study population comprised 80,247 university library users in Ogun State, Nigeria. A sample size of 1,513 was determined using the Krejcie and Morgan (1970) method. Universities were stratified into federal, state, and private categories, and respondents were purposively selected. The findings indicate high-quality service delivery in university libraries in …

Eng 2901-003 Structure Of English, Melissa Caldwell

Fall 2024

No abstract provided.

Shifting The Paradigm With Wednesday Addams: An Intersectional Analysis Of The First (Autistic) Female Latinx Detective, Camille Bassett, Jason Gilmore

Communication Studies and Philosophy Student Research

For centuries, Autistic people have been portrayed in media through two dehumanizing stereotypes, the robot and the superhuman savant. Together, the robot and the superhuman savant combine into one of the most popular hybrid stereotypes to appear in media: the detective. Past detectives have been almost exclusively white male characters, a longstanding pattern that erases Autistic women and people of color, among others. In 2022, however, Netflix’s spinoff series of The Addams Family, Wednesday, brought to the screen the first-ever female Latinx detective. This study is a thematic analysis of Wednesday as a character, the autism …

A Review Of Optical Flow Velocimetry In Fluid Mechanics, Gauresh Raj Jassal, Bryan E. Schmidt

Faculty Scholarship

Optical flow methods have been developed over the past two decades for application to particle image velocimetry (PIV) images with the goal of acquiring higher resolution measurements of the velocity field than conventional cross-correlation (CC)-based techniques. Numerous optical flow velocimetry (OFV) algorithms have been devised to solve the ill-posed optical flow problem, with various physics-inspired strategies to tailor them to fluid flows. While OFV can be applied to continuous scalar fields, it has demonstrated the most success on images of tracer particles, i.e. traditional planar PIV images. Compared to state-of-the-art CC algorithms, OFV methods have demonstrated an order of magnitude …

English The Effectiveness Of A Group Counseling Program In Positive Psychology In Reducing Anxiety And Depression And Improving The Quality Of Life Among High School Students, Faten Alrawahneh

Journal of King Abdulaziz University: Educational and Psychological Sciences

Substance abuse is one of the critical and acute public health problems, being related to various health, psychological, and life issues. It was found that narrative therapy is an effective intervention to reduce the psychological dysphoria caused by addiction. Objectives: The objectives of this research are defining whether narrative group therapy is a helpful instrument to reduce depression and anxiety in high school students with addiction and to improve the overall life quality of such students. Methods: The structured quasi-experimental design, with pretest-posttest conditions were selected; one group was experimental, receiving counseling, and the other was not. The total number …

Against Moralizing Nature: Latin American Romanticism And The Aporias Of The Ecocritical Turn, Claudio Aguayo-Borquez

Modern Languages Faculty Publications

This article argues that the ecocritical turn in literary criticism reproduces the dualisms it seeks to avoid, especially the contradiction between nature and culture. At the same time, ecocriticism risks the veneration of Nature already practiced and promoted within the Romantic tradition in the global epoch of primitive accumulation during the 19th century. To sustain this argument, this article follows three main steps. In the first place, it establishes a characterization of Romanticism's attitude towards Nature, defining it as the literaturization of Nature, following Abrams' notion of supernatural naturalism and Jean Luc-Nancy and Philippe Lacoue-Labarthe's definition of Romanticism as the …

Study Of Long-Term Spectral Evolution And X-Ray And Γ-Ray Correlation Of Blazars Seen By Hawc, R. Alfaro, C. Alvarez, A. Andrés, J. C. Arteaga-Velázquez, D. Avila Rojas, H. A.Ayala Solares, R. Babu, E. Belmont-Moreno, A. Bernal, K. S. Caballero-Mora, T. Capistrán, A. Carramiñana, F. Carreón, S. Casanova, U. Cotti, J. Cotzomi, S. Coutiño De León, E. De La Fuente, D. Depaoli, N. Di Lalla, R. Diaz Hernandez, B. L. Dingus, M. A. Duvernois, M. Durocher, J. C. Diaz-Velez, K. Engel, C. Espinoza, K. L. Fan, N. Fraija, S. Fraija, J. A. Garcia-Gonzalez, F. Garfias, A. Gonzalez Munoz, M. M. Gonzalez, J. A. Goodman, S. Groetsch, J. P. Harding, S. Hernandez-Cadena, I. Herzog, D. Huang, F. Hueyotl-Zahuantitla, A. Iriarte, V. Joshi, S. Kaufman, D. Kieda, A. Lara, W. H. Lee, J. Lee, H. Leon Vargas, J. T. Linnemann, A. L. Longinotti, G. Luis-Raya, K. Malone, O. Martinez, I. Martinez-Castellanos, J. Martinez-Castro, J. A. Matthews, P. Miranda-Romagnoli, J. A. Montes, E. Moreno, M. Mostafa, A. Nayerhoda, L. Nellen, M. U. Nisa, R. Noriega-Papaqui, N. Omodei, M. Osorio, Y. Perez Araujo, E. G. Perez-Perez, C. D. Rho, D. Rosa-Gonzalez, E. Ruiz-Velasco, H. Salazar, D. Salazar-Gallegos, A. Sandoval, M. Schneider, M. Serna-Franco, A. J. Smith, Y. Son, R. W. Springer, O. Tibolla, K. Tollefson, I. Torres, R. Torres-Escobedo, R. Turner, F. Urena-Mena, E. Varela, L. Villasenor, Xiaojie Wang, I. J. Watson, K. Whitaker, E. Willox, S. Yun-Carcamo, H. Zhou

Physics Faculty Research & Creative Works

The HAWC Observatory collected 6 yr of extensive data, providing an ideal platform for long-term monitoring of blazars in the very high energy (VHE) band, without bias toward specific flux states. HAWC continuously monitors blazar activity at TeV energies, focusing on sources with a redshift of z ≤ 0.3, based on the Third Fermi-LAT Catalog of High-Energy sources. We specifically focused our analysis on Mrk 421 and Mrk 501, as they are the brightest blazars observed by the HAWC Observatory. With a data set of 2143 days, this work significantly extends the monitoring previously published, which was based on 511 …

Marginalized, Secularized, And Popularized? The Prevalence And Patterns Of Paranormal Belief In The United Kingdom, Tom Clark, Joseph O. Baker, Christoper D. Bader

Sociology Faculty Articles and Research

There is growing recognition of the prevalence of paranormal beliefs in Western countries. However, most of this interest has been focused on the United States and robust, comparative data remain limited. This study extends this literature to report findings from a national survey of the United Kingdom designed to assess the prevalence and patterns of paranormal beliefs. Although there are many similarities to previous research, the results also suggest that there are significant differences in the scope, clustering, and patterns of paranormalism across contexts. The study makes four contributions to research on the paranormal by a) reiterating the continuing popularity …

University Of New Hampshire 2024-2025 Faculty Senate Xxix - February 10, 2025 Minutes Summary, Faculty Senate

Faculty Senate Agendas & Minutes

No abstract provided.

Crow's Nest, February 10, 2025, Crow's Nest Staff

Crow's Nest

The February 10, 2025, issue of Crow's Nest.

Juggling In The Glass Center, Nicole Burkett

Marian Library Blog Archive

Stained-glass artwork on loan from the Marian Library adorns a sunlit walkway in the Roger Glass Center for the Arts, encouraging students and visitors to humbly share their talents.

Glucagon-Like Peptide-1 Receptor Agonists Improve Metabolic Dysfunction-Associated Steatotic Liver Disease Outcomes, Brandon Havranek, Rebecca Loh, Beatriz Torre, Rachel Redfield, Dina Halegoua-De Marzio

Division of Gastroenterology and Hepatology Faculty Papers

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the leading cause of chronic liver disease and is associated with significant cardiovascular morbidity and mortality. This study aims to investigate the association of glucagon-like peptide-1 (GLP-1) agonists with major cardiovascular events, clinically significant portal hypertension events, and all-cause mortality in patients with MASLD. A large, population-based retrospective cohort study was conducted using the TriNetX platform, which provided real-time access to electronic health records of 634,265 adult patients with MASLD/MASH. Propensity score matching (PSM) was employed to create two cohorts: A GLP-1 agonists group and a control group without GLP-1 agonists usage. Hazard …

California Teacher Librarians & The Differences They Make, Keith Curry Lance, Mary Ann Harlan

Learning Hub

In August 2024, the California Department of Education released data gathered via its 2022-23 school library evaluation. Following are major findings of an analysis of this dataset focusing on factors associated with where there are credentialed teacher librarians and how their presence helps to shape school library programs—details about staffing levels, library access, staff activities, collection size and budget, and implementation of the Model School Library Standards. Because data were reported by a voluntary sample covering approximately a third of California public schools, the dataset was not adequate to generate state totals or averages. Most responding schools had on-campus libraries. …

Locational Data And The Public Interest, William A. Herbert, Micahel Goodchild, Richard Appelbaum, Jeremy Crampton, Gary Langham, Krzysztof Janowicz, Mei-Po Kwan, Katina Michael, Lisa Schamess

Publications and Research

This article presents a paper developed by the AAG Organizing Committee on Locational Information and the Public Interest through a summit held in Santa Barbara, California in June 2022. The summit resulted in goals and ideas for addressing the issues that arise from the present environment for geodata, whereby public, private, and third-sector entities can tap into publicly available locational information with relatively little regulation on its access or use. The Committee articulates four goals: (1) develop a research agenda extending across disciplines, (2) outline educational resources and strategies to guide ethical practice, (3) devise a pathway to increase public …

Changemaker: Justin Pruett : Juris Doctorate : More Than Words: Insurance Lawyer Justin Pruett L'11 Takes A Different Route Into The Courtroom 2-10-2025, Roger Williams University School Of Law

Life of the Law School (1993- )

No abstract provided.

Exploring Mental Health In Veterinary Students: Common Stressors And Effective Coping Strategies: A Narrative Review, Rahib K. Islam, Emily K. Cobb, Hannah K. Mccowan, Kylie Watson, Kaustuv Bhattacharya, Anjali Chandra, Warda Mohiuddin, Karen Gruszynski, Amanda H. Wilkerson, John J. Dascanio, Robert E. Davis, Vinayak K. Nahar

School of Medicine Faculty Publications

INTRODUCTION: Veterinary students face significant challenges impacting their mental health and wellbeing. The rigorous academic curriculum, high expectations, and demanding clinical training create an environment of intense pressure and constant stress. This review explores the demographic and psychosocial variables influencing mental health outcomes, highlighting common stressors and coping strategies. METHODS: A systematic literature search was conducted using PubMed, CAB Abstracts, and Google Scholar. Studies published up to 2021 involving veterinary students were included. Twenty-one peer-reviewed studies met the inclusion criteria. Demographic data, stressors, mental health measures, and coping strategies were extracted and analyzed. Studies focused on various mental health aspects, …

A Critical Appraisal Of Poverty In The Context Of Nature-Based Communities: Selected Cases From The Philippines, Carla Edith Gonzales Jimena

Dissertations and Theses

The Philippines is considered one of the wealthiest countries in both Southeast Asia and the world when measured by biodiversity, mineral resources and natural resources. It is also one of the most highly mineralized countries on earth. However, despite these natural endowments, when measured by established economic and human development indices the Philippines remains poor. Using critical perspectives derived from Marxist tradition, William Chambliss' theory of law and its dialectical nature, Immanuel Wallerstein's World Systems Theory, and Fred Block's structural mechanism of the state, this study aimed to critically appraise the persistence of poverty in nature-based communities in the Philippines. …

Axl Signaling In Cancer: From Molecular Insights To Targeted Therapies, Monika Yadav, Akansha Sharma, Ketki Patne, Saba Tabasum, Jyoti Suryavanshi, Laxminarayan Rawat, Marc Machaalani, Marc Eid, Rana Singh, Toni Choueiri, Soumitro Pal, Akash Sabarwal

Department of Microbiology and Immunology Faculty Papers

AXL, a member of the TAM receptor family, has emerged as a potential target for advanced-stage human malignancies. It is frequently overexpressed in different cancers and plays a significant role in various tumor-promoting pathways, including cancer cell proliferation, invasion, metastasis, epithelial-mesenchymal transition (EMT), angiogenesis, stemness, DNA damage response, acquired therapeutic resistance, immunosuppression, and inflammatory responses. Beyond oncology, AXL also facilitates viral infections, including SARS-CoV-2 and Zika highlighting its importance in both cancer and virology. In preclinical models, small-molecule kinase inhibitors targeting AXL have shown promising anti-tumorigenic potential. This review primarily focuses on the induction, regulation and biological functions of AXL …