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Metacognition And The 5cs Of Positive Youth Development Programs: A Review Of Metacognitive Interventions, Omolola A. Odejimi, Leslie F. Clark Mar 2025

Metacognition And The 5cs Of Positive Youth Development Programs: A Review Of Metacognitive Interventions, Omolola A. Odejimi, Leslie F. Clark

Journal of Youth Development

Positive youth development (PYD) programs have increased positive outcomes for adolescents, however research on the underlying change processes in these programs remains limited. The 5Cs (Competence, Confidence, Character, Caring and Connection) of PYD are a framework of desirable outcomes for youth programs. Change to metacognition is proposed as a mechanism by which PYD programming accomplishes these outcomes. This review describes findings from metacognitive interventions with PYD-relevant outcomes in adolescents aged 10-24. Fifteen electronic databases were searched using keyword phrases related to “metacognitive intervention” and “adolescents”. Seventeen studies met inclusion criteria. Included studies addressed 2 of the 5 goals of PYD …


The Accuracy Of Artificial Intelligence In The Diagnosis Of Soft Tissue Sarcoma: A Systematic Review And Meta-Analysis, Feras Al-Obeidat, Asrar Rashid, Wael Hafez, Hayssam Gibbaoui, Gilbert Ayoub, Sokiyna Al Ameer, Arun Kumar Venkatachalapathi, Munier Gador, Surra Hassan, Mahmad Anwar Ibrahim, Nouran Hamza, Ivan Cherrez-Ojeda Mar 2025

The Accuracy Of Artificial Intelligence In The Diagnosis Of Soft Tissue Sarcoma: A Systematic Review And Meta-Analysis, Feras Al-Obeidat, Asrar Rashid, Wael Hafez, Hayssam Gibbaoui, Gilbert Ayoub, Sokiyna Al Ameer, Arun Kumar Venkatachalapathi, Munier Gador, Surra Hassan, Mahmad Anwar Ibrahim, Nouran Hamza, Ivan Cherrez-Ojeda

All Works

Introduction Soft-tissue sarcomas (STSs) constitute a rare group of malignancies. Diagnostic biopsies require experts and are invasive with long diagnostic intervals. Artificial intelligence (AI)-based STS models may serve as accurate detection and categorization tools; however, their diagnostic performance remains questionable. Method The PubMed, Scopus, and Web of Science databases were searched for related studies published until January 10, 2024. Studies that developed or used AI-based models to diagnose STS were included. Results Nine studies were included in this meta-analysis. The common effects model yielded an accuracy of 0.8923 [0.8831; 0.9016], and the random effects model yielded an accuracy of 0.8524 …


Exploring Ai Technology In Grammar Performance Testing For Children With Learning Disabilities, Dimitra V. Katsarou, Evangelos Mantsos, Soultana Papadopoulou, Maria Sofologi, Efthymia Efthymiou, Ilias Vasileiou, Kalliopi Megari, Maria Theodoratou, Georgios A. Kougioumtzis Mar 2025

Exploring Ai Technology In Grammar Performance Testing For Children With Learning Disabilities, Dimitra V. Katsarou, Evangelos Mantsos, Soultana Papadopoulou, Maria Sofologi, Efthymia Efthymiou, Ilias Vasileiou, Kalliopi Megari, Maria Theodoratou, Georgios A. Kougioumtzis

All Works

The study explores the application of artificial intelligence (AI) in addressing grammar challenges among children with learning disabilities, aiming to assess the efficacy of an AI-driven tool for personalized interventions. A sample of 100 children aged 8–12, diagnosed with learning disabilities, was recruited from special education programs. Participants were divided into an experimental group (n = 50), which used an AI-based grammar assessment tool with personalized feedback, and a control group (n = 50), which completed conventional paper-based grammar tests without feedback. The AI tool administered adaptive grammar tasks, including sentence correction and verb conjugation, and performance was evaluated over …


Exploration Of Cytokines And Microbiome Among Males And Females With Diarrhea-Predominant Irritable Bowel Syndrome, Li Juen Chen, Anna M Plantinga, Robert Burr, Kevin Cain, Pamela Barney, Tor Savidge, Robert J Shulman, Margaret Heitkemper, Kendra Kamp Mar 2025

Exploration Of Cytokines And Microbiome Among Males And Females With Diarrhea-Predominant Irritable Bowel Syndrome, Li Juen Chen, Anna M Plantinga, Robert Burr, Kevin Cain, Pamela Barney, Tor Savidge, Robert J Shulman, Margaret Heitkemper, Kendra Kamp

Faculty, Staff and Students Publications

Background: Whether pathophysiological factors differ between males and females with irritable bowel syndrome-diarrhea (IBS-D) remains to be tested. To better understand potential sex differences, males with IBS-D were compared to naturally cycling females and to females with IBS-D taking hormonal contraception on plasma levels of cytokines and gut microbiome characteristics.

Methods: Males and females with Rome III IBS-D completed questionnaires and kept a daily symptom diary for 28 days. Blood and stool samples were collected between days 3 and 8 of the daily diary (estrogen-dominant days in naturally cycling females). Blood samples were analyzed for lipopolysaccharide (LPS)-stimulated and unstimulated cytokine …


A High-Lipid Diet Leads To Greater Pathology And Lower Tolerance During Infection, Weston Gerald Perrine, Erin Sauer, Ashley C. Love, Ashley Morris, Johnathan Novotny, Sarah Durant Mar 2025

A High-Lipid Diet Leads To Greater Pathology And Lower Tolerance During Infection, Weston Gerald Perrine, Erin Sauer, Ashley C. Love, Ashley Morris, Johnathan Novotny, Sarah Durant

Biological Sciences Faculty Publications and Presentations

Altered food landscapes contribute importantly to wildlife disease dynamics and may play a critical role in host heterogeneity in disease outcomes through changes in host diet composition. We explored the effects of dietary macronutrient composition on disease pathology and feeding behavior of canaries (Serinus canaria domestica) infected with Mycoplasma gallisepticum (MG). In the first experiment, we provided canaries with isocaloric diets composed of identical ingredients that varied in macronutrient content (high protein or high lipid) then MG- or sham-inoculated birds. In the second experiment, we offered both diets to canaries before and after MG or sham inoculation. In experiment one, …


Anesthetic Considerations For Repair Of Thoracoabdominal Aortic Aneurysms, David A Lyubashevsky, Thomas Powell, Ali Khalifa, Vicente Orozco-Sevilla, Daniel A Tolpin Mar 2025

Anesthetic Considerations For Repair Of Thoracoabdominal Aortic Aneurysms, David A Lyubashevsky, Thomas Powell, Ali Khalifa, Vicente Orozco-Sevilla, Daniel A Tolpin

Faculty, Staff and Students Publications

Anesthetic management of open thoracoabdominal aneurysm (TAAA) repair poses a number of challenges for even the most experienced of cardiovascular anesthesiologists. This procedure encompasses a large number of unique anesthetic techniques, including one-lung ventilation, invasive hemodynamic monitoring, left-heart bypass, massive transfusion, selective renal and visceral perfusion, and central nervous system monitoring with CSF drainage. In this article, we aim to describe the anesthetic management for thoracoabdominal aortic aneurysm repair, including preoperative workup, intraoperative management, as well as postoperative concerns in the intensive care unit.


Organizational Health Psychology: A Compilation Of Open Access Research For Future Industrial-Organizational Psychologists, Caitlin Lapine Mar 2025

Organizational Health Psychology: A Compilation Of Open Access Research For Future Industrial-Organizational Psychologists, Caitlin Lapine

Open Touro Created

2025

Organizational Health Psychology: A Compilation of Open Access Research for Future Industrial-Organizational Psychologists is a text designed for industrial organizational psychology graduate students and organizational practitioners working to make the workplace better for all employees. This open educational resource provides important scholarly journal articles that describe current findings in the occupational health space, including research conducted on the COVID-19 pandemic’s influence on current work.


On Strategy-Proofness And The Salience Of Single-Peakedness In A Private Goods Allotment Problem, Shurojit Chatterji, Jordi Masso, Shigehiro Serizawa Mar 2025

On Strategy-Proofness And The Salience Of Single-Peakedness In A Private Goods Allotment Problem, Shurojit Chatterji, Jordi Masso, Shigehiro Serizawa

Research Collection School Of Economics

We consider strategy-proof rules operating on a rich domain of preference profiles in a set up where multiple private goods have to be assigned to a set of agents with entitlements and where preferences display satiation. We show that if the rule is in addition tops-only, same-sided and individually rational with respect to the entitlements, then the preferences in the domain have to satisfy a variant of single-peakedness (referred to as multi-dimensional single-peakedness relative to the entitlements). We also provide a converse of this main finding. It turns out that this domain coincides with the one already identified in a …


Food Self-Sufficiency And Building-Integrated Urban Agriculture: Lessons From Singapore, Tomoki Fujii, Christoph Waibel, Xinyi Du, Zhongming Shi Mar 2025

Food Self-Sufficiency And Building-Integrated Urban Agriculture: Lessons From Singapore, Tomoki Fujii, Christoph Waibel, Xinyi Du, Zhongming Shi

Research Collection School Of Economics

Singapore aims to achieve 30 percent food self-sufficiency by 2030, known as the 30-by-30 target, and this paper reviews Singapore’s changing landscape for urban agriculture and its recent progress towards the 30-by-30 goal, highlighting key challenges such as land constraints, high production costs, and resource limitations. Building-integrated agriculture (BIA), which utilizes building surfaces such as rooftops, façades, and balconies for food production within urban environments, is examined as a potential way to increase self-sufficiency through a simulation. Despite the BIA’s potential, practical issues—including regulatory concerns and infrastructure limitations—must be addressed before it can be implemented at scale. Insights from Singapore’s …


Fintech’S Rise Reshaping Asean’S Financial Future, Swee Liang Tan Mar 2025

Fintech’S Rise Reshaping Asean’S Financial Future, Swee Liang Tan

Research Collection School Of Economics

Fintech can offset the diminishing effects of bank lending on economic growth. By leveraging innovative technologies, fintech companies can reduce transaction costs, address information asymmetry issues and streamline processes such as customer evaluation and risk assessment. This strategic collaboration between banks and fintech firms can lead to improved efficiency and effectiveness in financial services, such as pressuring traditional banks to innovate in areas such as customer interface and processes, ultimately boosting economic growth.


Unpacking Singapore’S Leasehold Relativity Table: An Empirical And Legal Analysis, Koon Shing Kwong, Jing Rong Goh, Seng Wei, Edward Ti Mar 2025

Unpacking Singapore’S Leasehold Relativity Table: An Empirical And Legal Analysis, Koon Shing Kwong, Jing Rong Goh, Seng Wei, Edward Ti

Research Collection School Of Economics

In Singapore, most land is state-owned, with the state generally issuing leasehold estates via state leases of not more than 99 years1, depending on the intended land use. Naturally, the value of a leasehold estate, which erodes over time as the lease approaches the end of its term, is a key component of the premium charged for lease renewals, or the tax imposed for permission given in relation to a development that would increase the value of the land. By law, the state valuation of leasehold land is prescribed by a leasehold relativity table colloquially known as ‘Bala’s Curve’ or …


The Relationship Between Food Insecurity And Emotional Eating During The Coronavirus Pandemic In Northern California, Andreza S.B. Souza, Marcelle M. Dougan, Giselle A.P. Pignotti Mar 2025

The Relationship Between Food Insecurity And Emotional Eating During The Coronavirus Pandemic In Northern California, Andreza S.B. Souza, Marcelle M. Dougan, Giselle A.P. Pignotti

Faculty Research, Scholarly, and Creative Activity

Objectives: This cross-sectional study examined the association between food insecurity and emotional eating and explored correlations between emotional eating and dietary behavior in the U.S during the pandemic. Methods: Participants (N = 515, 77.1 % female, 44.1 ± 14.7 years old) completed a validated online survey between August and November of 2020 including questions about food security and eating behaviors. A multivariable linear regression model was used to evaluate the association between food insecurity and emotional eating. Pearson correlations were calculated to assess the relationship between emotional eating and dietary behavior Results: Overall, 31.3 % of the participants experienced food …


Forward-Secure Hierarchical Delegable Signature For Smart Homes, Jianfei Sun, Guowen Xu, Yang Yang, Xuehuan Yang, Xiaoguo Li, Cong Wu, Zhen Liu, Guomin Yang, Robert H. Deng Mar 2025

Forward-Secure Hierarchical Delegable Signature For Smart Homes, Jianfei Sun, Guowen Xu, Yang Yang, Xuehuan Yang, Xiaoguo Li, Cong Wu, Zhen Liu, Guomin Yang, Robert H. Deng

Research Collection School Of Computing and Information Systems

Aiming to provide people with great convenience and comfort, smart home systems have been deployed in thousands of homes. In this paper, we focus on handling the security and privacy issues in such a promising system by customizing a new cryptographic primitive to provide the following security guarantees: (1) fine-grained, privacy-preserving authorization for smart home users and integrity protection of communication contents; (2) flexible self-sovereign permission delegation; (3) forward security of previous messages. To our knowledge, no previous system has been designed to consider these three security and privacy requirements simultaneously. To tackle these challenges, we put forward the first-ever …


Adaptive Deviation Learning For Visual Anomaly Detection With Data Contamination, Aanindya Sundar Das, Guansong Pang, Monowar Bhuyan Mar 2025

Adaptive Deviation Learning For Visual Anomaly Detection With Data Contamination, Aanindya Sundar Das, Guansong Pang, Monowar Bhuyan

Research Collection School Of Computing and Information Systems

Visual anomaly detection targets to detect images that notably differ from normal pattern, and it has found extensive application in identifying defective parts within the manufacturing industry. These anomaly detection paradigms predominantly focus on training detection models using only clean, unlabeled normal samples, assuming an absence of contamination; a condition often unmet in real-world scenarios. The performance of these methods significantly depends on the quality of the data and usually decreases when exposed to noise. We introduce a systematic adaptive method that employs deviation learning to compute anomaly scores end-to-end while addressing data contamination by assigning relative importance to the …


Faith Misplaced: Working Out The Roles Of Faith And Law In Pluralist Democracies, Seow Hon Tan Mar 2025

Faith Misplaced: Working Out The Roles Of Faith And Law In Pluralist Democracies, Seow Hon Tan

Research Collection Yong Pung How School Of Law

In pluralist democracies where legal and constitutional rights to freedom of conscience and religion exist, one can too readily-and sometimes, misguidedly - conclude that faith-based arguments, or arguments made by those who are religiously motivated, have little or no place in lawmaking. For example, it maybe thought that free and equal citizens have been accorded the freedom (not) to profess and practice a religion. Given the ubiquity of law and its impact on all, including those without a religion, if the religious were to shape the law from religious perspectives, freedom of others may be negatively impacted or rendered nugatory …


Revisiting Sentiment Analysis For Software Engineering In The Era Of Large Language Models, Ting Zhang, Ivana Clairine Irsan, Thung Ferdian, David Lo Mar 2025

Revisiting Sentiment Analysis For Software Engineering In The Era Of Large Language Models, Ting Zhang, Ivana Clairine Irsan, Thung Ferdian, David Lo

Research Collection School Of Computing and Information Systems

Software development involves collaborative interactions where stakeholders express opinions across various platforms. Recognizing the sentiments conveyed in these interactions is crucial for the effective development and ongoing maintenance of software systems. For software products, analyzing the sentiment of user feedback, e.g., reviews, comments, and forum posts can provide valuable insights into user satisfaction and areas for improvement. This can guide the development of future updates and features. However, accurately identifying sentiments in software engineering datasets remains challenging.This study investigates bigger large language models (bLLMs) in addressing the labeled data shortage that hampers fine-tuned smaller large language models (sLLMs) in software …


How To Securely Delegate And Revoke Partial Authorization Credentials, Meng Sun, Junzuo Lai, Wei Wu, Ye Yang, Cheng-Kang Chu, Robert H. Deng Mar 2025

How To Securely Delegate And Revoke Partial Authorization Credentials, Meng Sun, Junzuo Lai, Wei Wu, Ye Yang, Cheng-Kang Chu, Robert H. Deng

Research Collection School Of Computing and Information Systems

An attribute-based credential (ABC) system allows a user, obtaining a credential on a set of attributes from an issuer, to anonymously prove a subset of attributes to a service provider. Nowadays, delegation is an important requirement of ABC, which allows a user to delegate his credentials to other users. However, traditional delegatable ABC systems only support delegating a credential with all attributes. In many scenarios, an appropriate delegation is a user can delegate his credential on parts of attributes to others. Another requirement is revocation of credentials in case of unexpected events. In this article, we propose a delegatable and …


Dualopt: A Dual Divide-And-Optimize Algorithm For The Large-Scale Traveling Salesman Problem, Shipei Zhou, Yuandong Ding, Chi Zhang, Zhiguang Cao, Yan Jin Mar 2025

Dualopt: A Dual Divide-And-Optimize Algorithm For The Large-Scale Traveling Salesman Problem, Shipei Zhou, Yuandong Ding, Chi Zhang, Zhiguang Cao, Yan Jin

Research Collection School Of Computing and Information Systems

This paper proposes a dual divide-and-optimize algorithm (DualOpt) for solving the large-scale traveling salesman problem (TSP). DualOpt combines two complementary strategies to improve both solution quality and computational efficiency. The first strategy is a grid-based divide-and-conquer procedure that partitions the TSP into smaller subproblems, solving them in parallel and iteratively refining the solution by merging nodes and partial routes. The process continues until only one grid remains, yielding a high-quality initial solution. The second strategy involves a path-based divide-and-optimize procedure that further optimizes the solution by dividing it into sub-paths, optimizing each using a neural solver, and merging them back …


Simulation-Free Hierarchical Latent Policy Planning For Proactive Dialogues, Tao He, Lizi Liao, Yixin Cao, Yuanxing Liu, Yiheng Sun, Zerui Chen, Ming Liu, Bing Qin Mar 2025

Simulation-Free Hierarchical Latent Policy Planning For Proactive Dialogues, Tao He, Lizi Liao, Yixin Cao, Yuanxing Liu, Yiheng Sun, Zerui Chen, Ming Liu, Bing Qin

Research Collection School Of Computing and Information Systems

Recent advancements in proactive dialogues have garnered significant attention, particularly for more complex objectives (e.g. emotion support and persuasion). Unlike traditional task-oriented dialogues, proactive dialogues demand advanced policy planning and adaptability, requiring rich scenarios and comprehensive policy repositories to develop such systems. However, existing approaches tend to rely on Large Language Models (LLMs) for user simulation and online learning, leading to biases that diverge from realistic scenarios and result in suboptimal efficiency. Moreover, these methods depend on manually defined, context-independent, coarse-grained policies, which not only incur high expert costs but also raise concerns regarding their completeness. In our work, we …


Enhancing Item‑Level Bundle Representation For Bundle Recommendation, Xiaoyu Du, Kun Qian, Yunshan Ma, Xinguang Xiang Mar 2025

Enhancing Item‑Level Bundle Representation For Bundle Recommendation, Xiaoyu Du, Kun Qian, Yunshan Ma, Xinguang Xiang

Research Collection School Of Computing and Information Systems

Bundle recommendation approaches offer users a set of related items on a particular topic. The current state-of-the-art (SOTA) method utilizes contrastive learning to learn representations at both the bundle and item levels. However, due to the inherent difference between the bundle-level and item-level preferences, the item-level representations may not receive sufficient information from the bundle affiliations to make accurate predictions. In this article, we propose a novel approach, Enhanced Bundle Recommendation (EBRec), which incorporates two enhanced modules to explore inherent item-level bundle representations. First, we propose to incorporate the bundle-user-item (B-U-I) high-order correlations to explore more collaborative information, thus to …


Individual Liberty, Safety And Police Liabilities Under The Mental Health (Care And Treatment) Act, Gary Kok Yew Chan Mar 2025

Individual Liberty, Safety And Police Liabilities Under The Mental Health (Care And Treatment) Act, Gary Kok Yew Chan

Research Collection Yong Pung How School Of Law

How should a society strike a balance between the objective of ensuring safety from dangers that may be posed by individuals believed to have a mental disorder and the deprivation of their liberty? How should police officers discharge their duties in apprehending such individuals with a view to conveying them to a medical practitioner at a psychiatric institution? These legal issues took centrestage in the Singapore High Court decision of Mah Kiat Seng v Attorney-General in which the apprehended individual brought claims in false imprisonment against a police officer. The decision examined the underlying purposes of the Singapore Mental Health …


Mobilizing Frontline Workers Against Wage Theft, Terri Adams-Fuller, John Ahlquist, Jacob Grumbach, Tess Starman Phd Mar 2025

Mobilizing Frontline Workers Against Wage Theft, Terri Adams-Fuller, John Ahlquist, Jacob Grumbach, Tess Starman Phd

Sociology: Faculty Publications

We use an original survey of frontline U.S. workers in five low-wage industries to investigate the prevalence of perceived wage theft and the effectiveness of messages aimed at mobilizing in response. We find that over 14% of workers report recent incidents of late- or underpayment. These workers are both more supportive of union representation and more willing to search for a new job. Using an embedded survey experiment, we study workers’ willingness to respond to a “call to action” on behalf of coworkers experiencing wage theft. Whether the call to action comes from a hypothetical neighbor or a coworker, mobilizing …


Great Power Competition And The Effects Of Global Fragmentation On International Law, Bryan H. Druzin Mar 2025

Great Power Competition And The Effects Of Global Fragmentation On International Law, Bryan H. Druzin

Vanderbilt Journal of Transnational Law

No abstract provided.


Moral Hazard In International Economic Law, Zachary Mollengarden Mar 2025

Moral Hazard In International Economic Law, Zachary Mollengarden

Vanderbilt Journal of Transnational Law

No abstract provided.


Optimal Surveillance For Detecting Sarcoma Lung Metastasis – A Systematic Review, Neha Malik, Kate Krause, Emily Z Keung, Heather G Lyu, Heather Lillemoe, Christopher Scally, Keila Torres, Kelly Hunt, Mary Austin, Christina L Roland Mar 2025

Optimal Surveillance For Detecting Sarcoma Lung Metastasis – A Systematic Review, Neha Malik, Kate Krause, Emily Z Keung, Heather G Lyu, Heather Lillemoe, Christopher Scally, Keila Torres, Kelly Hunt, Mary Austin, Christina L Roland

Faculty, Staff and Student Publications

Introduction: Accurate diagnosis of lung metastasis for patients with soft tissue sarcoma (STS) can impact overall survival, but there is considerable variability in imaging utilized to detect metastasis. Chest x-ray (CXR) or computer tomography (CT) scan of the chest are the most common studies in current practice.

Methods: A systematic literature search was performed. Databases were searched from inception to January 3, 2024. Articles were reviewed to determine if CXR or CT chest was associated with improved overall or recurrence-free survival in patients with STS. Articles were also reviewed for data on cost-effectiveness of CXR versus CT chest. The quality …


Proceedings Of The National Cancer Institute Workshop On Combining Immunotherapy With Radiotherapy: Challenges And Opportunities For Clinical Translation, Zachary S Morris, Sandra Demaria, Arta M Monjazeb, Silvia C Formenti, Ralph R Weichselbaum, James Welsh, Heiko Enderling, Jonathan D Schoenfeld, Joshua D Brody, Heather M Mcgee, Michele Mondini, Michael S Kent, Kristina H Young, Lorenzo Galluzzi, Sana D Karam, Willemijn S M E Theelen, Joe Y Chang, Mai Anh Huynh, Adi Daib, Sean Pitroda, Caroline Chung, Raphael Serre, Clemens Grassberger, Jie Deng, Quaovi H Sodji, Anthony T Nguyen, Ravi B Patel, Simone Krebs, Anusha Kalbasi, Caroline Kerr, Claire Vanpouille-Box, Logan Vick, Todd A Aguilera, Irene M Ong, Fernanda Herrera, Hari Menon, Deedee Smart, Jalal Ahmed, Robyn D Gartrell, Christina L Roland, Fatemeh Fekrmandi, Binita Chakraborty, Eric H Bent, Tracy J Berg, Alan Hutson, Samir Khleif, Andrew G Sikora, Lawrence Fong Mar 2025

Proceedings Of The National Cancer Institute Workshop On Combining Immunotherapy With Radiotherapy: Challenges And Opportunities For Clinical Translation, Zachary S Morris, Sandra Demaria, Arta M Monjazeb, Silvia C Formenti, Ralph R Weichselbaum, James Welsh, Heiko Enderling, Jonathan D Schoenfeld, Joshua D Brody, Heather M Mcgee, Michele Mondini, Michael S Kent, Kristina H Young, Lorenzo Galluzzi, Sana D Karam, Willemijn S M E Theelen, Joe Y Chang, Mai Anh Huynh, Adi Daib, Sean Pitroda, Caroline Chung, Raphael Serre, Clemens Grassberger, Jie Deng, Quaovi H Sodji, Anthony T Nguyen, Ravi B Patel, Simone Krebs, Anusha Kalbasi, Caroline Kerr, Claire Vanpouille-Box, Logan Vick, Todd A Aguilera, Irene M Ong, Fernanda Herrera, Hari Menon, Deedee Smart, Jalal Ahmed, Robyn D Gartrell, Christina L Roland, Fatemeh Fekrmandi, Binita Chakraborty, Eric H Bent, Tracy J Berg, Alan Hutson, Samir Khleif, Andrew G Sikora, Lawrence Fong

Faculty, Staff and Student Publications

Radiotherapy both promotes and antagonises tumour immune recognition. Some clinical studies show improved patient outcomes when immunotherapies are integrated with radiotherapy. Safe, greater than additive, clinical response to the combination is limited to a subset of patients, however, and how radiotherapy can best be combined with immunotherapies remains unclear. The National Cancer Institute-Immuno-Oncology Translational Network-Society for Immunotherapy of Cancer-American Association of Immunology Workshop on Combining Immunotherapy with Radiotherapy was convened to identify and prioritise opportunities and challenges for radiotherapy and immunotherapy combinations. Sessions examined the immune effects of radiation, barriers to anti-tumour immune response, previous clinical trial data, immunological and …


Development And Characterization Of Orthotopic Patient-Derived Xenograft Models Of Peritoneal Metastatic Mucinous Appendiceal Adenocarcinoma, Ichiaki Ito, Vinay K Pattalachinti, Abdelrahman Mg Yousef, Saikat Chowdhury, Mohammad M Fanaeian, Emaan Haque, Betul Beyza Gunes, Mahmoud Yousef, Emma R Salle, Mohammad A Zeineddine, Shuangxi Ji, Ruonan Li, Wenyi Wang, Beth A Helmink, Melissa W Taggart, Michael G White, Keith F Fournier, Natalie W Fowlkes, John Paul Shen Mar 2025

Development And Characterization Of Orthotopic Patient-Derived Xenograft Models Of Peritoneal Metastatic Mucinous Appendiceal Adenocarcinoma, Ichiaki Ito, Vinay K Pattalachinti, Abdelrahman Mg Yousef, Saikat Chowdhury, Mohammad M Fanaeian, Emaan Haque, Betul Beyza Gunes, Mahmoud Yousef, Emma R Salle, Mohammad A Zeineddine, Shuangxi Ji, Ruonan Li, Wenyi Wang, Beth A Helmink, Melissa W Taggart, Michael G White, Keith F Fournier, Natalie W Fowlkes, John Paul Shen

Faculty, Staff and Student Publications

Background: Appendiceal adenocarcinomas (AAs) are a rare and heterogeneous group of tumors for which few preclinical models exist. The lack of preclinical models of AA has hindered drug development and is a major factor in why AA remains without a single FDA-approved systemic treatment.

Materials and methods: Tumors from 16 patients with appendiceal neoplasms (15 AA and one HAMN) were implanted into flank and peritoneal cavity of immunodeficient mice leading to the successful establishment of 3 AAPDX models. Histological, immunohistochemical, genetic, and transcriptomic comparison of patient and PDX tumors were performed.

Results: Higher tumor grade, peritoneal implantation, and RAS/RAF mutation …


Rhabdoid Tumor Of The Kidney And Soft Tissues: Results From National Wilms Tumor Study-5 And Children's Oncology Group Study Aren0321, James I Geller, Lindsay A Renfro, Paul E Grundy, Elizabeth J Perlman, John A Kalapurakal, Peter F Ehrlich, Jackie Biegel, Vicki Huff, Anne B Warwick, Arnold Paulino, Elizabeth A Mullen, Najat C Daw, Fredric A Hoffer, Zelig Tochner, Kenneth Gow, Eric Gratias, Deborah A Ward, James R Anderson, Conrad V Fernandez, Jeffrey S Dome Mar 2025

Rhabdoid Tumor Of The Kidney And Soft Tissues: Results From National Wilms Tumor Study-5 And Children's Oncology Group Study Aren0321, James I Geller, Lindsay A Renfro, Paul E Grundy, Elizabeth J Perlman, John A Kalapurakal, Peter F Ehrlich, Jackie Biegel, Vicki Huff, Anne B Warwick, Arnold Paulino, Elizabeth A Mullen, Najat C Daw, Fredric A Hoffer, Zelig Tochner, Kenneth Gow, Eric Gratias, Deborah A Ward, James R Anderson, Conrad V Fernandez, Jeffrey S Dome

Faculty, Staff and Student Publications

Purpose: National Wilms Tumor Study-5 (NWTS-5) and AREN0321 evaluated the outcomes of children with rhabdoid tumor of the kidney (RTK) and malignant rhabdoid tumor of soft tissues (MRT).

Patients and methods: Eligible patients with RTK were enrolled prospectively on NWTS-5 (1995-2002) and treated with carboplatin and etoposide alternating with cyclophosphamide (Regimen RTK). Patients with RTK or MRT were enrolled on AREN0321 (2005-2012) and received vincristine, doxorubicin, and cyclophosphamide alternating with carboplatin, cyclophosphamide, and etoposide (Regimens UH-1 or dose-reduced Revised UH-1). We report event-free survival (EFS) and overall survival (OS) from each study.

Results: Thirty patients received Regimen RTK on NWTS-5; …


An Antibody-Toxin Conjugate Targeting Cd47 Linked To The Bacterial Toxin Listeriolysin O For Cancer Immunotherapy, Benjamin R Schrank, Yifan Wang, Annette Wu, Nhat Tran, Daeyong Lee, Jared Edwards, Kristin Huntoon, Shiyan Dong, Jonghoon Ha, Yifan Ma, Adam J Grippin, Seong Dong Jeong, Abin Antony, Mengyu Chang, Minjeong Kang, Thomas D Gallup, Albert C Koong, Jing Li, Kyuson Yun, Betty Y S Kim, Wen Jiang Mar 2025

An Antibody-Toxin Conjugate Targeting Cd47 Linked To The Bacterial Toxin Listeriolysin O For Cancer Immunotherapy, Benjamin R Schrank, Yifan Wang, Annette Wu, Nhat Tran, Daeyong Lee, Jared Edwards, Kristin Huntoon, Shiyan Dong, Jonghoon Ha, Yifan Ma, Adam J Grippin, Seong Dong Jeong, Abin Antony, Mengyu Chang, Minjeong Kang, Thomas D Gallup, Albert C Koong, Jing Li, Kyuson Yun, Betty Y S Kim, Wen Jiang

Faculty, Staff and Student Publications

Antigen-presenting cells phagocytose tumor cells and subsequently cross-present tumor-derived antigens. However, these processes are impeded by phagocytosis checkpoints and inefficient cytosolic transport of antigenic peptides from phagolysosomes. Here, using a microbial-inspired strategy, we engineered an antibody-toxin conjugate (ATC) that targets the 'don't eat me' signal CD47 linked to the bacterial toxin listeriolysin O from the intracellular bacterium Listeria monocytogenes via a cleavable linker (CD47-LLO). CD47-LLO promotes cancer cell phagocytosis by macrophages followed by LLO release and activation to form pores on phagolysosomal membranes that enhance antigen cross-presentation of tumor-derived peptides and activate cytosolic immune sensors. CD47-LLO treatment in vivo significantly …


Wmh Contributions To Cognitive Impairment: Rationale And Design Of The Diverse Vcid Study, Charles Decarli, Kumar B Rajan, Lee-Way Jin, Jason Hinman, David K Johnson, Danielle Harvey, Myriam Fornage Mar 2025

Wmh Contributions To Cognitive Impairment: Rationale And Design Of The Diverse Vcid Study, Charles Decarli, Kumar B Rajan, Lee-Way Jin, Jason Hinman, David K Johnson, Danielle Harvey, Myriam Fornage

Faculty, Staff and Student Publications

As awareness of dementia increases, more individuals with minor cognitive complaints are requesting clinical assessment. Neuroimaging studies frequently identify incidental white matter hyperintensities, raising patient concerns about their brain health and future risk for dementia. Moreover, current US demographics indicate that ≈50% of these individuals will be from diverse backgrounds by 2060. Racial and ethnic minority populations bear a disproportionate burden of vascular risk factors magnifying dementia risk. Despite established associations between white matter hyperintensities and cognitive impairment, including dementia, no study has comprehensively and prospectively examined the impact of individual and combined magnetic resonance imaging measures of white matter …