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Articles 56851 - 56880 of 1441032
Full-Text Articles in Entire DC Network
Compliant Parallel-Guiding Mechanisms Scaling Data, Jared Hunter, Larry L. Howell Dr.
Compliant Parallel-Guiding Mechanisms Scaling Data, Jared Hunter, Larry L. Howell Dr.
ScholarsArchive Data
Force/displacement and strain data is captured for various geometric scales of compliant parallel-guided mechanisms.
Jc Polyomavirus Pooled Seropositivity Prevalence In Healthy Subjects, Lenka J. Kimla
Jc Polyomavirus Pooled Seropositivity Prevalence In Healthy Subjects, Lenka J. Kimla
Walden Dissertations and Doctoral Studies
JC polyomavirus (JCV) causes progressive multifocal leukoencephalopathy in immunocompromised individuals and has been linked to cancer development. To-date, no information is available about the JCV seroprevalence in the healthy (nondiseased) population or whether this virus is ecologically connected to humans. The aim of this systematic literature review and meta-analysis was to the estimate the overall seroprevalence of JCV in the healthy human population by age, region, and testing method. A meta-analysis conducted on 24 studies revealed a pooled JCV seroprevalence of 60% (95% CI, 55% - 65%) with statistically significant effect size (z = 32.93, p < 0.001). Meta-regression and subgroup analyses with STATA18 showed that age and region had a strong positive predictive value on prevalence (R = .578, R2 = 0.334, F(2,52) = 12.543, p < 0.001) whereas the testing method had no significant effect on prevalence. The theories that grounded this study were the ecological model and the systems theory, which support the study result that JCV appears to be ubiquitous in the human population with JCV being acquired very early in life. The results of the systematic literature review indicated that JCV is transmitted via fecal-oral and respiratory routes within and outside of families. Most infants are infected with JCV by the age of 6 months and JCV seronegativity may not be indicative of a lack of an underlying JCV infection. JCV seropositivity increases with age, which is most probably by viral reactivation due to immune senescence. These findings have positive social change implications with JCV treatment, screening, and vaccine development.
Leveraging Arginine Catabolism To Treat Metabolic Complications, Yiming Zhang
Leveraging Arginine Catabolism To Treat Metabolic Complications, Yiming Zhang
Arts & Sciences Graduate Student Theses and Dissertations
Fasting and caloric restriction are effective to treat patients with pre-diabetes or metabolic dysfunction-associated steatotic liver disease (MASLD), previously known as non-alcoholic fatty liver disease (NAFLD), but intensive lifestyle changes are difficult for many to implement and sustain. Therefore, by identifying and studying fasting-mediated signals, we hope to elicit and convey the therapeutic effects of fasting against MASLD without actual physiological fasting. We discovered a key pathway in the liver through unbiased transcriptomic screening in fasted mice, a novel glucose fasting-activated effector: the amino acid hydrolase, arginase 2 (ARG2). Our previously published data demonstrates that forced hepatocyte-specific Arg2 overexpression is …
Tau Oligomers Resist Phase Separation, Lathan Lucas, Phoebe S Tsoi, Josephine C Ferreon, Allan Chris M Ferreon
Tau Oligomers Resist Phase Separation, Lathan Lucas, Phoebe S Tsoi, Josephine C Ferreon, Allan Chris M Ferreon
Faculty, Staff and Students Publications
Tau is a microtubule-associated protein that undergoes liquid-liquid phase separation (LLPS) to form condensates under physiological conditions, facilitating microtubule stabilization and intracellular transport. LLPS has also been implicated in pathological Tau aggregation, which contributes to tauopathies such as Alzheimer's disease. While LLPS is known to promote Tau aggregation, the relationship between Tau's structural states and its phase separation behavior remains poorly defined. Here, we examine how oligomerization modulates Tau LLPS and uncover key distinctions between monomeric, oligomeric, and amyloidogenic Tau species. Using dynamic light scattering and fluorescence microscopy, we monitored oligomer formation over time and assessed oligomeric Tau's ability to …
Celebrating Tolkien’S Legacy: Essays (2024), By Nancy Bunting, Seamus Hamill-Keays, And Toby Widdicombe, Douglas Charles Kane
Celebrating Tolkien’S Legacy: Essays (2024), By Nancy Bunting, Seamus Hamill-Keays, And Toby Widdicombe, Douglas Charles Kane
Journal of Tolkien Research
Book review, by Douglas Charles Kane, of Celebrating Tolkien’s Legacy: Essays (2024), by Nancy Bunting, Seamus Hamill-Keays, and Toby Widdicombe
Governing Generative Ai, Daryl Lim
Governing Generative Ai, Daryl Lim
Akron Law Review
This Article paper explores the evolving landscape of copyright law in the age of generative artificial intelligence, dissecting the multifaceted challenges and opportunities it presents for creators, legal practitioners, and policymakers. Part I, “Governing Authorship,” delves into the existential questions AI poses to traditional notions of creativity and authorship, illustrating the tension between innovation and the preservation of human creators’ rights within existing legal frameworks. Part II, “Governing Infringement,” examines the intricate issues of copyright infringement in the digital era, especially the unauthorized use of copyrighted content by AI for training purposes and the exploration of private ordering mechanisms as …
Reimagining Imperfection: A Multimodal Critical Discourse Analysis Of Women Characters In Studio Ghibli Animated Films, Xue Yang, Roslina Mamat, Zaid Mohd Zin
Reimagining Imperfection: A Multimodal Critical Discourse Analysis Of Women Characters In Studio Ghibli Animated Films, Xue Yang, Roslina Mamat, Zaid Mohd Zin
Journal of International Women's Studies
This study aims to explore the representation of flawed women characters in Studio Ghibli animated films, focusing on the themes of environmentalism, anti-war sentiments, and personal growth. Utilizing a qualitative approach and multimodal critical discourse analysis (MCDA), the research examines five selected films—Nausicaä of the Valley of the Wind, My Neighbor Totoro, Kiki’s Delivery Service, Princess Mononoke, and Spirited Away—with some additional attention to Howl’s Moving Castle. The analysis employs Fairclough’s three-dimensional model, visual grammar, and feminist film theory to scrutinize the visual and verbal elements used to represent these characters. The findings …
Support For The United States In The United Nations On Cold War Issues And The Distribution Of Foreign Aid To Central American And Caribbean Countries, Gerald R. Webster
Support For The United States In The United Nations On Cold War Issues And The Distribution Of Foreign Aid To Central American And Caribbean Countries, Gerald R. Webster
The Geographical Bulletin
The agenda of the General Assembly of the United Nations has been dominated by Cold War battles between the United States and the Soviet Union during much of the organization's 45-year history. Do countries who support the United States on votes associated with the Cold War receive larger quantities of U.S. foreign assistance? This paper examines two hypotheses pertaining to this question with regard to the voting behavior of 12 Central American and Caribbean countries between 1970 and 1987. The cross-sectional analysis finds significant evidence for a link between U.N. voting behavior and the quantities of per capita U.S. foreign …
Volume 33-1 Complete Issue, C. Nicholas Raphael
Volume 33-1 Complete Issue, C. Nicholas Raphael
The Geographical Bulletin
Volume 33-1 Complete Issue
The Abandoned Shipwreck Act Of 1987 And The Reaction Of State Historic Preservation Offices, Kelly A. Victor, Gary M. Victor
The Abandoned Shipwreck Act Of 1987 And The Reaction Of State Historic Preservation Offices, Kelly A. Victor, Gary M. Victor
The Geographical Bulletin
The Abandoned Shipwreck Act of 1987 is perhaps the most important piece of recent federal legislation enacted affecting underwater archaeology and the preservation of underwater historic sites. With this short statute, the federal government vested title to virtually all historic shipwrecks in navigable water to the states. The act also changed existing legal principles in order to allow the states to enact their own laws to protect and preserve underwater historic resources. This article begins with a discussion of the Abandoned Shipreck Act of 1987- what it is, what it does and how it has changed the law related to …
Review Of Building Representative Community Archives: Inclusive Strategies In Practice, Shir Bach
Review Of Building Representative Community Archives: Inclusive Strategies In Practice, Shir Bach
Journal of Contemporary Archival Studies
In Building Representative Community Archives, editor Hannah Leah Crummé sets out to provide a practical guide to building community archives through ten case studies. The volume covers three types of projects: oral history, collection and curation, and reassessment. With some exceptions, community-created and community-maintained archives are sidelined in this collection. The majority of case studies describe academic special collections units embracing community archival principles and practices to meet their own goals, and some chapters do not meaningfully engage with community archives at all. Though many chapters succeed on their own terms, the misleading framing produces a collection that is …
Library And Information Science Research; A Scopus-Based Bibliometric Analysis From 2014 To 2023, Khalid Alfouzan, Ikram Ul Haq, Ata Ur Rehman, Gulnaz Elahi, Faisal Shahzad
Library And Information Science Research; A Scopus-Based Bibliometric Analysis From 2014 To 2023, Khalid Alfouzan, Ikram Ul Haq, Ata Ur Rehman, Gulnaz Elahi, Faisal Shahzad
Library Philosophy and Practice (e-journal)
Aim: The purpose of this study is to the highlight research growth in Library and Information Science (LIS) for the last decade (2014-2023) at the global level as indexed in the Scopus database.
Methodology: The retrospective research approach has been used on the dataset retrieved from the Scopus database. We used the “advanced document search” technique, selected the targeted period and typed the “Library and Information Sciences”. We chose only “Article” and “Review” from the document type filter and English from the language filter. The selected bibliometric properties were analyzed and tabular demonstrations of the periodic growth with …
Teaching Archival Intelligence Through An Immersive Class Experience, Dulce Kersting-Lark
Teaching Archival Intelligence Through An Immersive Class Experience, Dulce Kersting-Lark
Journal of Contemporary Archival Studies
While the University of Idaho does not offer course work in library and information sciences, there is a growing interest in humanities and social science departments on campus to offer skill-based classes that are often found in MLIS programs with an emphasis in archival studies. In particular, building skills considered essential to a public historian has become a goal for the history department's graduate program. As a result, the head of the university library's archives was approached to teach a credit-bearing course on working in archives as well as developing strategies for making archival material engaging to the public. This …
Using Ai To Make Accessible Accessible Content, Melinda Turner
Using Ai To Make Accessible Accessible Content, Melinda Turner
Faculty Other Scholarly Works
This professional development session will explore how to leverage AI tools, specifically Google’s NotebookLM, to create accessible learning materials for college students. Participants will learn how to use NotebookLM to transform existing content into more accessible formats. The session will cover practical strategies for implementing AI to improve readability and comprehension for all learners including students with disabilities, non-native English speakers, and students with varying learning preferences. We will discuss how to create transcripts for audio/video files and ensure content is well-organized and easy to navigate. This session will also highlight the importance of evidence-based practices in content creation and …
Eng 4390-099 Eng Studies Cap, Honors, Jeannie Ludlow
Postnatal Progressive Craniosynostosis: An Unusual Case Presentation Leading To Cascade Diagnosis For Multiple Generations, Jessica T. Ogawa, Maura Guyler, Krystal L. Tomei, Howard D. Wang
Postnatal Progressive Craniosynostosis: An Unusual Case Presentation Leading To Cascade Diagnosis For Multiple Generations, Jessica T. Ogawa, Maura Guyler, Krystal L. Tomei, Howard D. Wang
Faculty Scholarship
NM_000141.5: FGFR2 c.1032G>A is a pathogenic variant that causes Crouzon syndrome through activation of a new donor splice site. This clinical report highlights the intrafamilial variability that can exist with this specific variant. The proband is a 4-year-old boy who initially presented with concern for seizures. Computed tomography and magnetic resonance imaging revealed pancraniosynostosis and Chiari 1 malformation. Papilledema on fundoscopic exam and copper beaten appearance of the skull on imaging both suggested the presence of elevated intracranial pressure. Genetic testing identified c.1032G>A (p.Ala344=) in FGFR2. Familial testing and genetic evaluation confirmed the same pathogenic variant in the …
Understanding Young Adolescent Identity And Experiences Through Internal Dimensions: A Scoping Review, Dezeré J. Martin, Stacie K. Pettit, Sandra L. Stacki, Kristie W. Smith, Micki M. Caskey
Understanding Young Adolescent Identity And Experiences Through Internal Dimensions: A Scoping Review, Dezeré J. Martin, Stacie K. Pettit, Sandra L. Stacki, Kristie W. Smith, Micki M. Caskey
Curriculum and Instruction Faculty Publications and Presentations
The purpose of this study was to explore multiple facets of young adolescent identity and related experiences through a scoping literature review. Based on Gardenswartz and Rowe’s Four Layers of Diversity Model, we specifically examined extant literature around five of the internal dimensions: gender, sexuality, race, ethnicity, and physical ability. Two overarching research questions guided this investigation: What is the range and nature of current findings on young adolescent identity and experience? What gaps exist in research on young adolescent identity and experiences? To address these research questions, our research group conducted a scoping literature review using predetermined search strings …
College Council Meeting Minutes (February 25, 2025), Dmacc
College Council Meeting Minutes (February 25, 2025), Dmacc
College Council
No abstract provided.
Trends And Financial Burden Of Gastrointestinal Stromal Tumors In The United States: A Comprehensive Analysis Of United States Hospitalizations, Sneh Sonaiya, Raj Patel, Charmy Parikh, Dushyant Dahiya, Karan Yagnik, Nicholas Alonso Barnechea Alvarado, Chun-Han Lo, Kenneth Chow, Abbas Ali Hussain, Anushri Parikh, Pranav Patel, Babu P. Mohan
Trends And Financial Burden Of Gastrointestinal Stromal Tumors In The United States: A Comprehensive Analysis Of United States Hospitalizations, Sneh Sonaiya, Raj Patel, Charmy Parikh, Dushyant Dahiya, Karan Yagnik, Nicholas Alonso Barnechea Alvarado, Chun-Han Lo, Kenneth Chow, Abbas Ali Hussain, Anushri Parikh, Pranav Patel, Babu P. Mohan
Department of Internal Medicine Faculty Research
Background: Gastrointestinal stromal tumors (GISTs) are associated with a substantial economic burden to the healthcare system despite their relatively low incidence and prevalence compared to other more common malignancies. This study aimed to evaluate trends in GIST-related hospitalizations, inpatient mortality, and the financial burden of GISTs in the United States. Methods: The National Inpatient Sample (NIS) database from 2016 to 2020 was used to identify adult hospitalizations (age > 18 years) with a primary diagnosis of GIST. A multivariate logistic regression along with Chi-square and t-tests was performed using SAS 9.4 software to analyze inpatient GIST-associated mortality, inflation-adjusted total hospital charge …
Disability Measures Used In U.S. Federal Surveys Significantly Underreport Disability Status, Nastassia Vaitsiakhovich, Scott D. Landes, Jean P. Hall, Bonnielin K. Swenor
Disability Measures Used In U.S. Federal Surveys Significantly Underreport Disability Status, Nastassia Vaitsiakhovich, Scott D. Landes, Jean P. Hall, Bonnielin K. Swenor
Population Health Research Brief Series
U.S. federal surveys commonly use two question sets to measure disability: the American Community Survey (ACS-6) and the Washington Group Short Set (WG-SS). This data slice uses data from the 2011-2012 National Health Interview Survey to examine the percentage of disabled people captured by these two different survey sets. The authors find that both sets of questions significantly underreport disability statuses that are not directly addressed in their question prompts, including intellectual disability, developmental disability, birth defects, mental health disability, diabetes, and cancer.
Processing Parameter-Performance Nexus In 3d Printing Of Nanostructured Chiral Photonics, Kyle George, Nader Taheri-Qazvini, Peter D. Olmsted, Monirosadat Sadati
Processing Parameter-Performance Nexus In 3d Printing Of Nanostructured Chiral Photonics, Kyle George, Nader Taheri-Qazvini, Peter D. Olmsted, Monirosadat Sadati
Faculty Publications
Precisely crafted hierarchical architectures found in naturally derived biomaterials underpin the exceptional performance and functionality showcased by the host organism. In particular, layered helical assemblies composed of cellulose, chitin, or collagen serve as the foundation for some of the most mechanically robust and visually striking natural materials. By utilizing structured materials in additive manufacturing techniques such as extrusion-based 3D printing, the intrinsic deformation process can be used to implement bottom-up design of printed constructs, offering the potential to create intricate macroscale geometries with embedded nanoscale functionality. In this study, comprehensive rheological and rheo-optical characterization of structurally colored, photocurable liquid crystalline …
Prevalence Of Social Determinants Of Health Risk Factors Among And Their Impact On Viral Suppression, Consistent Visits, And No-Show Rates Among Persons With Hiv Who Identify As Hispanic, Mary Cowden, Ana Clavijo, Pragnya Iyengar, Ann Avery
Prevalence Of Social Determinants Of Health Risk Factors Among And Their Impact On Viral Suppression, Consistent Visits, And No-Show Rates Among Persons With Hiv Who Identify As Hispanic, Mary Cowden, Ana Clavijo, Pragnya Iyengar, Ann Avery
Faculty Scholarship
The current study examines the association between language preference, social determinants of health (SDOH) risk factors, viral load, and HIV care outcomes among individuals of Hispanic ethnicity in the United States. More than half (54%) of all participants reported having two or more unmet needs. Hispanic individuals were more likely to be at risk in 2 or more domains than their non-Hispanic counterparts. Food insecurity was the most common risk factor reported and when present, 51% of patients also reported financial resource strain. Surprisingly, when language preference was analyzed, English-preferring Hispanic patients were at higher risk of financial resource strain, …
Monitoring And Modeling Legacy Tree Response To Restoration Treatments In The Klamath Mountains, Oregon, Usa, Isaac Joseph Ball
Monitoring And Modeling Legacy Tree Response To Restoration Treatments In The Klamath Mountains, Oregon, Usa, Isaac Joseph Ball
Dissertations and Theses
Climate change and its disruption of historical drought and wildfire patterns pose a substantial threat to forest health in the western United States. This threat is compounded by past management practices like fire suppression. The largest, oldest, and most ecologically valuable trees are particularly vulnerable, making their conservation a key objective of climate-adaptive forest management. Restoration treatments such as mechanical thinning have been shown to enhance tree growth and drought resilience in dry conifer forests, but long-term monitoring is necessary to understand their sustained effects. This study used dendroecological tree-ring analysis to investigate the effects of thinning on the growth, …
Becoming A Learner: An Autoethnography, Joshua Dickinson
Becoming A Learner: An Autoethnography, Joshua Dickinson
Dissertations and Theses
It is well understood that attitudes toward language learning impact outcomes. This thesis uses autoethnography to explore the author's experiences learning German, in-class and independently, examining the interplay between motivation, attitudes, and the learning environment. I analyze personal journals and notes, employing graphic storytelling to illustrate their emotional journey. This paper draws upon existing literature on second language acquisition, particularly focusing on Dörnyei's L2 Motivational Self System and Ushioda's person-in-context approach. The study reveals how personal beliefs, self-doubt, and the limitations of traditional classroom settings impacted my motivation and ultimately, how reflection facilitated a renewed commitment to learning. In conclusion, …
Ultrasound-Triggered Release Of Vancomycin From A Novel Spinal Device: Antibiotic Release And Efficacy In Vivo, Lauren J. Delaney, Priscilla Machado, Ji-Bin Liu, Rachel Evans, Asia Winslow, Neil Zhao, Christopher K. Kepler, Rajkishen Narayanan, Teeto Ezeonu, Viren Soni, Gagan Kaushal, Rachel Hilliard, Thomas P. Schaer, Noreen J. Hickok, Flemming Forsberg
Ultrasound-Triggered Release Of Vancomycin From A Novel Spinal Device: Antibiotic Release And Efficacy In Vivo, Lauren J. Delaney, Priscilla Machado, Ji-Bin Liu, Rachel Evans, Asia Winslow, Neil Zhao, Christopher K. Kepler, Rajkishen Narayanan, Teeto Ezeonu, Viren Soni, Gagan Kaushal, Rachel Hilliard, Thomas P. Schaer, Noreen J. Hickok, Flemming Forsberg
Department of Orthopaedic Surgery Faculty Papers
Post-surgical spinal infection occurs in up to 20 % of patients, despite aggressive peri-operative antibiotic treatments. To improve prophylaxis, we have designed and evaluated an ultrasound-activated prophylactic antibiotic release system to combat post-surgical bacterial survival. Polylactic acid (PLA) clips (1 cm3) were 3D-printed with an interior reservoir (0.8 cm3) for carrying drug payload, specifically vancomycin (VAN). Under IACUC approval, clips were surgically implanted into the spines of sheep (n = 9) and swine (n = 2) by removing the spinous process at several levels of the lumbar spine. In the sheep, clips were insonated and the …
Immersive Modeling To Communicate And Manage Risks Of Water Shortages, David Rosenberg, Erki Porse
Immersive Modeling To Communicate And Manage Risks Of Water Shortages, David Rosenberg, Erki Porse
Civil and Environmental Engineering Faculty Publications
Our project goal is to use immersive online collaborative modeling as a tool for active learning to communicate and manage users conflicting risks of water shortages because decisions now to manage risk effect future risk. State-of-the art river basin forecasting tools provide probabilistic estimates of streamflow at hourly to annual scales. Water resource models quantify tradeoffs and risk across hundreds or thousands of scenarios of inflow and demand forecast out decades. Our project objectives are: 1) Formulate extreme scenarios for reservoir inflows without probabilities one to three years out that pose imminent risk of water shortages. 2) Hold immersive model …
Efficacy And Safety Of Mechanical Transvenous Lead Extraction: Median Follow-Up Analysis And Development Of An Experimental Model For Predicting Survival Post-Extraction, Shima Nasri, Sahar Samimi, Masoud Eslami, Khashayar Hematpour, Morteza Eslami, Hirad Yarmohammadi, Reza Mollazadeh, Mehrzad Rahmanian
Efficacy And Safety Of Mechanical Transvenous Lead Extraction: Median Follow-Up Analysis And Development Of An Experimental Model For Predicting Survival Post-Extraction, Shima Nasri, Sahar Samimi, Masoud Eslami, Khashayar Hematpour, Morteza Eslami, Hirad Yarmohammadi, Reza Mollazadeh, Mehrzad Rahmanian
Faculty, Staff and Student Publications
Background: Cardiac implantable electronic device (CIED) implantation is on the rise, accompanied by an increase in its inevitable complications such as different types of CIED infections that require further therapy and potential device extraction. Ensuring efficacy and safety remains paramount in transvenous lead extraction (TLE), given the complex nature of the procedure. The purpose of this study is to assess the outcomes of relatively low-cost mechanical TLE, including mid-term clinical follow-up, and to develop a predictive model for post-TLE survival. This study included all consecutive patients admitted for TLE at two tertiary medical centers between 2016 and 2021. Baseline characteristics, …
Potential Of Individual Upper-Limb Muscles To Contribute To Postural Tremor: Simulations From Neural Drive To Joint Rotation, Spencer A. Baker, Landon J. Beutler, Daniel B. Free, Dario Farina, Steven Knight Charles
Potential Of Individual Upper-Limb Muscles To Contribute To Postural Tremor: Simulations From Neural Drive To Joint Rotation, Spencer A. Baker, Landon J. Beutler, Daniel B. Free, Dario Farina, Steven Knight Charles
Faculty Publications
Background: It is unclear which muscles contribute most to tremor and should therefore be targeted by tremor suppression methods. Previous studies used mathematical models to investigate how upper-limb biomechanics affect muscles’ potential to generate tremor. These investigations yielded principles, but the models included at most only 15 muscles. Here we expand previous models to include 50 upper-limb muscles, simulate tremor propagation, and test the validity of the previously postulated principles. Methods: Tremor propagation was characterized using the gains between tremorogenic neural drive to the 50 muscles (inputs) and tremulous joint rotations in the 7 joint degreesof- freedom (DOF) from shoulder …
Power System Operations Modeling And Optimization Using Pyomo, Ahmad Heidari, Rui Bo
Power System Operations Modeling And Optimization Using Pyomo, Ahmad Heidari, Rui Bo
Graduate Student Research & Creative Works
"The energy sector has witnessed transformative advancements over the past few decades. Power systems, which form the backbone of modern society, have grown increasingly complex with the integration of renewable energy sources, energy storage, and emerging technologies. As these systems evolve, so does the need for efficient operation and optimization strategies to ensure reliability, sustainability, and economic performance.
Optimization plays a central role in solving real-world challenges such as balancing power generation and demand, minimizing operational costs, and managing grid constraints. However, many existing resources tend to focus either on theoretical aspects of optimization or rely on expensive, proprietary software …
Clostridioides Difficile Colonization Is Not Mediated By Bile Salts And Utilizes Stickland Fermentation Of Proline In An In Vitro Model, Xiaoyun Huang, April E Johnson, Joshua N Brehm, Thi Van Thanh Do, Thomas A Auchtung, Hugh C Mccullough, Armando I Lerma, Sigmund J Haidacher, Kathleen M Hoch, Thomas D Horvath, Joseph A Sorg, Anthony M Haag, Jennifer M Auchtung
Clostridioides Difficile Colonization Is Not Mediated By Bile Salts And Utilizes Stickland Fermentation Of Proline In An In Vitro Model, Xiaoyun Huang, April E Johnson, Joshua N Brehm, Thi Van Thanh Do, Thomas A Auchtung, Hugh C Mccullough, Armando I Lerma, Sigmund J Haidacher, Kathleen M Hoch, Thomas D Horvath, Joseph A Sorg, Anthony M Haag, Jennifer M Auchtung
Faculty, Staff and Students Publications
Treatment with antibiotics is a major risk factor for Clostridioides difficile infection, likely due to depletion of the gastrointestinal microbiota. Two microbiota-mediated mechanisms thought to limit C. difficile colonization include the conversion of conjugated primary bile salts into secondary bile salts toxic to C. difficile growth and competition between the microbiota and C. difficile for limiting nutrients. Using a continuous flow model that simulates the nutrient conditions of the distal colon, we investigated how treatment with 6 clinically used antibiotics influenced susceptibility to C. difficile infection in 12 different microbial communities cultivated from healthy individuals. Antibiotic treatment reduced microbial richness; …