Digital Commons Network^™

Identifiability And Model Selection Frameworks For Models Of High-Grade Glioma Response To Chemoradiation, Khushi C Hiremath, Kenan Atakishi, Ernesto A B F Lima, Maguy Farhat, Bikash Panthi, Mihir D Shanker, Sara Thrower, Jodi Goldman, Caroline Chung, Thomas E Yankeelov, David A Hormuth Ii

Faculty, Staff and Student Publications

We have developed a family of biology-based mathematical models of high-grade glioma (HGG), capturing the key features of tumour growth and response to chemoradiation. We now seek to quantify the accuracy of parameter estimation and determine, when given a virtual patient cohort, which model was used to generate the tumours. In this way, we systematically test both the parameter and model identifiability. Virtual patients are generated from unique growth parameters whose growth dynamics are determined by the model family. We then assessed the ability to recover model parameters and select the model used to generate the tumour. We then evaluated …

Conformal Predictive Intervals In Survival Analysis: A Resampling Approach, Jing Qin, Jin Piao, Jing Ning, Yu Shen

Faculty, Staff and Student Publications

The distribution-free method of conformal prediction has gained considerable attention in computer science, machine learning, and statistics. Candès et al. extended this method to right-censored survival data, addressing right-censoring complexity by creating a covariate shift setting, extracting a subcohort of subjects with censoring times exceeding a fixed threshold. Their approach only estimates the lower prediction bound for type I censoring, where all subjects have available censoring times regardless of their failure status. In medical applications, we often encounter more general right-censored data, observing only the minimum of failure time and censoring time. Subjects with observed failure times have unavailable censoring …

The Microbiome-Restorative Potential Of Ibezapolstat For The Treatment Of Clostridioides Difficile Infection Is Predicted Through Variant Polc-Type Dna Polymerase Iii In Lachnospiraceae And Oscillospiraceae, Ashok Kumar

Faculty, Staff and Student Publications

Ibezapolstat (IBZ), a first-in-class antibiotic targeting the PolC-type DNA polymerase III alpha-subunit (PolC) in low G + C bacteria, is in clinical development for the treatment of Clostridioides difficile infection (CDI). In the phase 2 trials, IBZ had potent activity against C. difficile while sparing or causing regrowth of Lachnospiraceae, Oscillospiraceae, and Erysipelotrichales, common commensal low G + C bacteria. The purpose of this study was to utilize in silico approaches to better interpret the narrower than expected IBZ spectrum of activity. IBZ susceptibility to human commensal microbiota was predicted using genomic analysis and PolC phylogenetic tree construction in relation …

Ven In Combination With 10-Day Dec In Newly Diagnosed Elderly Or Relapsed/Refractory Acute Myeloid Leukemia, And High-Risk Myelodysplastic Syndrome: Long Term Follow-Up Of A Phase 2 Trial, Mahesh Swaminathan, Courtney D Dinardo, Abhishek Maiti, Naveen Pemmaraju, Maro Ohanian, Guillermo Garcia-Manero, Gautam Borthakur, Farhad Ravandi, Guillermo Montalban-Bravo, Tapan M Kadia, Yesid Alvarado, Elias J Jabbour, Nicholas J Short, William G Wierda, Nitin Jain, Steven M Kornblau, Lucia Masarova, Sherry A Pierce, Wei Qiao, Jing Ning, Hagop Kantarjian, Marina Y Konopleva

Faculty, Staff and Student Publications

No abstract provided.

Long-Term Patient-Reported Bowel And Urinary Quality Of Life In Patients Treated With Intensity-Modulated Radiotherapy Versus Intensity-Modulated Proton Therapy For Localized Prostate Cancer, Kimberly R Gergelis, Miao Bai, Jiasen Ma, David M Routman, Bradley J Stish, Thomas M Pisansky, Richard Choo

Faculty, Staff and Student Publications

Purpose: This study aimed to compare long-term patient-reported outcomes in bowel and urinary domains between intensity-modulated radiotherapy (IMRT) and intensity-modulated proton therapy (IMPT) for localized prostate cancer.

Methods and materials: Patients with clinical T1-T2 prostate cancer receiving IMRT or IMPT at a tertiary cancer center from 2015-2018 were analyzed to determine the changes in the prospectively collected bowel function (BF), urinary irritative/obstructive symptoms (UO), and urinary incontinence (UI) domains of EPIC-26. The mean changes in EPIC-26 scores were evaluated from pretreatment to 24 months post-radiotherapy for each modality. A score change >50% of the baseline standard deviation was considered a …

Methylome-Wide Association Analyses Of Lipids And Modifying Effects Of Behavioral Factors In Diverse Race And Ethnicity Participants, Eric A Whitsel, Mindy Szeto, Laura M Raffield, Scott Ratliff, Yuxuan Wang, Xuzhi Wang, Alison E Fohner, Megan T Lynch, Yesha M Patel, S Lani Park, Huichun Xu, Braxton D Mitchell, Joshua C Bis, Nona Sotoodehnia, Jennifer A Brody, Bruce M Psaty, Gina M Peloso, Michael Y Tsai, Stephen S Rich, Jerome I Rotter, Jennifer A Smith, Sharon L R Kardia, Alex P Reiner, Leslie Lange, Myriam Fornage, James S Pankow, Mariaelisa Graff, Kari E North, Charles Kooperberg, Ulrike Peters

Faculty, Staff and Student Publications

Circulating lipid concentrations are clinically associated with cardiometabolic diseases. The phenotypic variance explained by identified genetic variants remains limited, highlighting the importance of searching for additional factors beyond genetic sequence variants. DNA methylation has been linked to lipid concentrations in previous studies, although most of the studies harbored moderate sample sizes and exhibited underrepresentation of non-European ancestry populations. In addition, knowledge of nongenetic factors on lipid profiles is extremely limited. In the Population Architecture Using Genomics and Epidemiology (PAGE) Study, we performed methylome-wide association analysis on 9,561 participants from diverse race and ethnicity backgrounds for HDL-c, LDL-c, TC, and TG …

Un-Silencing Dickinson: Emily Dickinson's Aversion To The Male Body And Heterosexuality In "My Life Had Stood–– A Loaded Gun", Cassandra Barron

Global Tides

This paper examines Emily Dickinson's aversion to heterosexual marriage and sexual initiation in her poem "My Life had stood-- a Loaded Gun". The ethics of deciphering through identifying and categorizing potentially Queer authors and texts impacts our understandings of frequently canonized authors such as Emily Dickinson. Emily Dickinson's nineteenth-century American context informed her ability to write deliberately about her experience of subversive sexual desire. Instead, Dickinson utilizes images of death, apathy, and immortality to illustrate her revulsion toward the male body and heterosexual marriage. This paper illustrates how utilizing Queer and feminist theories illuminates new and potential understandings of Emily …

Duty, Foreseeability, And The Negligent Infliction Of Mental Distress, Mark A. Beede

Maine Law Review

Under early common law if the act of a person gave rise to an action at law, he would be liable for resulting damages regardless of fault. A person acted at his peril. The limitation on liability, if any, lay not with a concept of duty but with a medieval sort of proximate cause. “There is little trace of any notion of. . . an obligation to any one individual, as essential to the tort. The defendant's obligation to behave properly apparently was owed to all the world.” With the merging of the common law actions of trespass and trespass …

The Development And Consequences Of The "Good Faith" Exception To The Exclusionary Rule And The Qualified "Good Faith" Immunity From Liability Under Section 1983, Philip M. Coffin Iii, Paul F. Driscoll

Maine Law Review

The remedies fashioned to redress violations of the fourth amendment to the United States Constitution continue to be the subject of much judicial, legislative, and scholarly inquiry. In striking the balance between the need to protect individual freedom and the need to protect society from criminal activity, the Supreme Court and Congress have developed two principal remedies for fourth amendment violations: the exclusionary rule and civil actions under 42 U.S.C. § 1983 or under theories of constitutional tort. on the development of both of these remedies it is assumed that their effectiveness is the true measure of fourth amendment liberties. …

Saintly Cinema: Modelling The Icon In The Flowers Of St. Francis And Andrei Rublev, Alexander Hart

Journal of Religion & Film

Throughout the history of the cinema, filmmakers have turned to the visual arts for inspiration in creating spiritual styles on film. In this essay, it is argued that Roberto Rossellini’s The Flowers of St. Francis (1950) and Andrei Tarkovsky’s Andrei Rublev (1966) were influenced by Giotto di Bondone’s frescos and Andrei Rublev’s Eastern Orthodox icons, respectively. Committed to realism, Rossellini adopts Giotto’s proto-Renaissance, humanist art as a model for a spiritual style in which the Transcendent is manifested through the natural world. Subverting terrestrial reality, Tarkovsky adopts the aesthetic principles of the Eastern Orthodox icon, translating Pavel Florensky’s concepts of …

“The Amber Campfire“ By Ureltu, Hang Lin

Kritika Kultura

No abstract provided.

Full Issue, Kritika Kultura

Kritika Kultura

No abstract provided.

Desi Dreams In America, Sri Craven

Kritika Kultura

No abstract provided.

Deimperialization Of Difficult Heritage Museums Of Political Repression In Kazakhstan, Dmitriy Melnikov, Anastasia Mitrofanova, Svetlana Riazanova

Kritika Kultura

In this article, we employ a decolonial methodology to question whose voices and histories are highlighted and whose are silenced in museum exhibitions. This methodology is employed to analyze the memorial museums situated on sites associated with state-induced violence, or, more precisely, within the premises of the Karaganda Corrective Labor Camp (the museum in Dolinka and the “ALZHIR” memorial complex). Our objective is to examine how these museums endeavor to reclaim these sites as significant for national history and identity. The museums employ various strategies to deimperialize the message conveyed through their exhibits and to find a balance between the …

Reimagining Decolonization In East Asia: The Mingeikan And Memories Of Japan’S Colonization Of Korea, Christina Mengying Wang

Kritika Kultura

After discovering beauty in the “folk crafts” (mingei) of Korea, Yanagi Sōetsu (1889–1961), an art critic, philosopher, and founder of the Mingei Movement, established the Japan Folk Crafts Museum (Nihon Mingeikan) in 1936. The Mingeikan, with its roots in Japan’s colonization of Korea, plays an uneven role in mediating the postmemory (the memory of those with no direct experience of WWII) of the current generation because the museum does not provide explicit reference to its colonial roots in its exhibitions. Yanagi’s original sentiments in comparison to the museum’s current iteration make for an important case study in understanding how decolonization …

Decolonizing Memory And Examining The Naga Identity In The Works Of Easterine Kire, Paloma Chaterji

Kritika Kultura

Colonization can be twofold: external and internal. For a socio-geographic space like Nagaland, a state in the Northeast of India, colonialism has presented itself through Britain, and even India itself; these multiple faces of colonialism have influenced and destabilized this hilly state. It was the British who had the maximum influence on Nagaland. India, even after its independence from the British in 1947, implemented certain strategies that smelt of British imperialism, whichultimately affected Nagaland and Northeast India as a whole. Thus, referencing the novels by the Naga woman writer, Easterine Kire, namely, Sky is My Father: A Naga Village Remembered …

Decolonizing Memory: Omnibus Life Writing In Post-1989 Romania, Ioana Luca

Kritika Kultura

This essay conceptualizes omnibus life writing—collective autobiographical volumes—as a means of decolonizing memories of communism and the transition in Romania. I argue that omnibus life writing offers a viable framework for challenging entrenched postcommunist narratives and fostering a relational and intersectional model of remembering the recent past. Through an analysis of Ioana Pârvulescu’s Și eu am trăit în communism [I’ve Also Lived under Communism, 2015], Dan Lungu and Amelia Gheorghiţă’s Cărţi, filme, muzici şi alte distracţii din communism [Books, Movies, Music, and Other Entertainment under Communism, 2014] and Cartea copilăriilor [The Book of Childhoods, 2016], and the Prima dată series …

Paabat: Provincializing Postmemory In Merlie Alunan’S Poems On The Balangiga Encounter Of 1901, Ian Harvey A. Claros

Kritika Kultura

This essay deploys the Waray word for haunting, apparition, and feeling—paabat—to examine Merlie Alunan’s poems about the Balangiga Encounter of 1901 and its aftermath in the anthology Running with Ghosts and Other Poems (2017). This historical event transpired when the townsfolk launched a surprise attack against the American soldiers stationed in Balangiga, a town in Samar, Philippines. Despite its success, the Americans harshly retaliated by pacifying the entire island through militarization, massacre, and arson. Alunan’s poetry attempts to reconstruct a range of events and subjectivities that constitute this traumatic history. Initially, it can be posited that her poetics and self-reflexivity …

Alaála: Tropical Memory, Christian Jil R. Benitez

Kritika Kultura

This essay considers a moment in José Rizal’s novel El Filibusterismo (1891)—namely, the substitution of the Spanish figure of “black King Melchor” with the folk “King of the Indios,” Bernardo Carpio, in the eyes of a native coachman—with a critical attention to how such an instant of comparison unfolds. The essay first ruminates on the crucial phrase deployed by Rizal to signify the moment, pensar naturalmente, which has been interpreted differently across various translations of the novel, but specifically rendered here as alaála or remembering. Through a brief philological examination of the latter Filipino word, regarding it as a material …

Decolonizing National And Imperial Memories: From Postcolonial To Decolonial And Beyond, Jarula M.I. Wegner

Kritika Kultura

This article describes a discursive shift at the beginning of the twenty-first century in academic and public debates from postcolonial to decolonial critiques and asks what this means for the study of national and imperial memories. While some critics, like Robert J. C. Young, see this shift within postcolonial discourse, others, like Sylvia Wynter, believe that postcolonial theory itself needs to be decolonized. Regardless of whether one believes the shift is taking place within postcolonial studies or caused from outside, in any case it presents at least twelve complex transformations. While many of the characteristics hark back to a longer …

Decolonizing National And Imperial Memories: Introduction, Jarula M.I. Wegner, Jocelyn S. Martin, Mary M. Mccarthy, Ruramisai Charumbira

Kritika Kultura

Building on Frantz Fanon’s insights into the intricate entanglements of colonialism, nation-states, and memories, there have been increasing calls to decolonize national and imperial memories. This introduction sketches the wider historical context within which these calls emerged, the collaboration that led to this special issue, and the contributions it makes to the wider debate.The introduction observes a general rise in calls for decolonization around the globe. The appeal to decolonize national and imperial memories was a response to at least three significant historical developments. First, the insight that mid-twentieth century decolonization remained incomplete, second, the widespread “memory boom” of the …

On Exasperated Isles, Joff P. N. Bradley

Kritika Kultura

This essay is an experimental piece of writing that brings together an array of thinkers from different traditions. Readers will encounter allusions to the Heideggerian Marxism of Axelos, the schizoanalysis of Deleuze and Guattari, and the pre-Socratics such as Heraclitus. Badiou is present, alongside Glissant, Nietzsche, and Bernard Stiegler. Karl Marx also makes an appearance. My project is to rethink the question of the unthought and the open system. I have been exploring this theme in various contexts, and for nearly a decade, I have been revisiting the excellent philosophy of Kostas Axelos. Axelos is a thinker who is rarely …

Living The Coast: On Property And Possession, The Netherlands And Indonesia, And The Free Sea, Rick Dolphijn

Kritika Kultura

When Sigmund Freud visited the Netherlands in the 1920s, he oversaw the Dutch landscape while travelling by rowing boats, carriages, and on foot. The reclamation of the Zuyderzee especially made an impression. He concluded that this drive for culture to control nature was similar to how the Ego wanted to control the Id. Of course, this was not a recent phenomenon in the Netherlands. During two earlier visits (in 1908 and 1910), Freud visited the major museums of the Netherlands where he was especially interested in the landscape painters of the seventeenth century. Landscape is actually one of those Dutch …

Heterotopos Of Desert Island, Woosung Kang

Kritika Kultura

This essay attempts to elucidate the uniqueness of the concept of desert island in Gilles Deleuze’s thinking, juxtaposing it with Carl Schmitt’s idea of struggle between the land and the sea. Especially, Deleuze’s notion of “desert island” is to be reread and revisited in terms of archipelagic literality of islands themselves. Deleuze’s concept of “desert island” is different from other conceptualizations of island in two critical aspects. Firstly, it does not metaphorize something other than island itself; its desertedness has nothing to do with utopian or apocalyptic representation of what the continent lacks. Secondly, it does not feed on the …

Transcultural Identity In Tan Twan Eng’S The Garden Of Evening Mists, Zhen Wang, Kean Yew Lee, Kee Chye Ho

Kritika Kultura

The Garden of Evening Mists by Tan Twan Eng narrates the progression from apprenticeship of a Malaysian Chinese woman, Teoh Yun Ling, to her romantic relationship with a Japanese gardener, Nakamura Aritomo, expanding the space for identity writing in Malaysian English literature that reflects the interactions among diverse cultures. This article discusses Yun Ling’s adaptation of Japanese culture at the acculturation stage, her rediscovery of Chinese culture at the deculturation stage, and her transcultural practice of different cultures at the neoculturation stage, in light of transculturation theory. It argues that Yun Ling’s ongoing negotiation, while involving a collision between the …

Reconstructing Normalcy: Identity And Trauma In The Last Of Us Video Games Saga, Jaime Oliveros Garcia

Kritika Kultura

This article argues that normalcy and trauma are processes central in understanding the narratives of the video games saga The Last of Us. As such, the article will, after a brief introduction, offer the theoretical framework, in which identity, avatarization, normalcy, and trauma will be defined. These terms are key for the analysis: with the players’ connivance, the narrative delves into the identity of the main characters of the saga so that players can infer how they aim to find a normalcy that is, because of the circumstances that the game offers as the plot, unattainable. Afterwards, the article will …

The Posthuman Evolution Of A Hazardous Transcorporeality: Tracy K. Smith’S Poetics Of Water From “Thirst” To Wade In The Water, Bahareh Azad

Kritika Kultura

This study analyzes Tracy K. Smith’s poetry through the lens of ecological materialism and Stacy Alaimo’s concept of transcorporeality, which emphasizes the fluidity and vitality of bodies and their interconnectedness. Tracing the evolution of Smith’s ethicopolitical concerns, I explore the elemental and transcorporeal forces in her work that create a poetics of fluidity. Additionally, I argue that Smith’s poetic trajectory marks a significant shift away from humanist frameworks, advancing toward a politically charged conception of Black marginality. By examining Smith’s poem “Watershed” in relation to Muriel Rukeyser’s The Book of the Dead, this study investigates the development of a posthuman …

Editor’S Introduction, Vincenz Serrano

Kritika Kultura

No abstract provided.

Texas Institute For The Preservation Of History And Culture Newsletter - April 2025, Texas Institute For The Preservation Of History And Culture

Newsletter Collections

No abstract provided.

Fostering Success: The Need For Continued Foster Care Beyond Age Twenty-One, Louisa Twitchell

California Western Law Review

No abstract provided.