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Scoping Review Of Socio-Ecological Factors Contributing To Sleep Health Disparities In Children With Autism Spectrum Disorder, Megan L. Wenzell, Carolyn E. Ievers-Landis, Sehyun Kim, Samantha Desimio, Siobhan Aaron, Meng Miao Apr 2025

Scoping Review Of Socio-Ecological Factors Contributing To Sleep Health Disparities In Children With Autism Spectrum Disorder, Megan L. Wenzell, Carolyn E. Ievers-Landis, Sehyun Kim, Samantha Desimio, Siobhan Aaron, Meng Miao

Faculty Scholarship

Given the high prevalence of sleep problems in children with autism spectrum disorder (ASD), there is a critical need to examine how sleep problems may be exacerbated for children exposed to social and environmental adversity. Guided by the socio-ecological model, this review aimed to evaluate factors linked to sleep health disparities (SHDs) in children with ASD, determine possible gaps/limitations in existing literature, and identify possible solutions. A scoping review was selected to ascertain what is known about SHDs in ASD. Four databases identified articles from 2004 to 2023. Included articles were those conducted in children with ASD that focused on …


Implementation & Evaluation Of A Neonatal Intensive Care Unit Transition To Early Intervention Program For High-Risk Infants: A Pilot Study, Erin Price, Otd, Otr/L, Cnt, Ntmtc, Amy Carroll Otd, Otr/L Apr 2025

Implementation & Evaluation Of A Neonatal Intensive Care Unit Transition To Early Intervention Program For High-Risk Infants: A Pilot Study, Erin Price, Otd, Otr/L, Cnt, Ntmtc, Amy Carroll Otd, Otr/L

Department of Occupational Therapy Posters and Presentations

Background

Advances in medicine have increased the survival rate of preterm infants. It is well documented that preterm infants have increased risk for developmental delays (Heiny et al., 2020; Pineda et al., 2020) . Additionally, after long stays in the NICU, families report anxiety and feeling unprepared to care for their fragile child at home (Cheong at al., 2020; Garfield et al., 2014; Aloysius et al., 2018; Lakshmanan et al., 2019) . Preterm infants have fewer developmental delays when enrolled in a program that fosters development of skills and provides caregiver education; however, there is often a 4-5 month gap …


University Recognizes 2024-25 Hall Of Fame Inductees, Jordan Karnbach Apr 2025

University Recognizes 2024-25 Hall Of Fame Inductees, Jordan Karnbach

University of Mississippi News

OXFORD, Miss. – The University of Mississippi has inducted 10 seniors into the 2024-25 Hall of Fame, one of the highest honors given to Ole Miss students.


Parasite Contamination Of Soil In Different Peruvian Locations And Outside Built Environments, Lucia Estela Mejia, Katherine Elizabeth Keegan, Lizbet Pilar Patricio Alvarez, Javier Jorge Mora, Fernanda Espinoza Vega, Emilio Rey Mejia, Patrick Olivas Herrera, Elisa Palomino Pando, Zhen Zeng, Athos Silva De Oliveira, Maria Jose Villar Mondragon, Barton Slatko, Eric J Wetzel, Rojelio Mejia Apr 2025

Parasite Contamination Of Soil In Different Peruvian Locations And Outside Built Environments, Lucia Estela Mejia, Katherine Elizabeth Keegan, Lizbet Pilar Patricio Alvarez, Javier Jorge Mora, Fernanda Espinoza Vega, Emilio Rey Mejia, Patrick Olivas Herrera, Elisa Palomino Pando, Zhen Zeng, Athos Silva De Oliveira, Maria Jose Villar Mondragon, Barton Slatko, Eric J Wetzel, Rojelio Mejia

Faculty, Staff and Students Publications

Background: Soil is a reservoir for many parasites that can affect human and animal health, especially in tropical regions where soil-transmitted helminths and protozoa thrive. Understanding how environmental factors influence parasite distribution will provide a basis for relating how climate changes may intensify their impacts, altering parasite habitats and increasing transmission risks. We surveyed soil parasite prevalence, burden, and diversity in several different Peruvian environmental ecologies to catalog current parasite presence and provide a baseline for future surveys.

Methods: A total of 198 soil samples from 43 locations across three Peruvian regions-Tingo María (TM) (Amazon rainforest), Andabamba/Marabamba (A/M) (Andean highlands), …


Protocol For A Multisite, Observational Clinical Study Of The Association Between Skin Colour And Pulse Oximeter Accuracy In Children Undergoing Cardiac Catheterisation (Pach Study), Athar M Qureshi, Christopher P Bonafide, Elizabeth E Foglia, Jeffery Feldman, Meghan B Lane-Fall, Jennifer M Lynch, Anna Chien, Michelle Dunn, Michael L O'Byrne Apr 2025

Protocol For A Multisite, Observational Clinical Study Of The Association Between Skin Colour And Pulse Oximeter Accuracy In Children Undergoing Cardiac Catheterisation (Pach Study), Athar M Qureshi, Christopher P Bonafide, Elizabeth E Foglia, Jeffery Feldman, Meghan B Lane-Fall, Jennifer M Lynch, Anna Chien, Michelle Dunn, Michael L O'Byrne

Faculty, Staff and Students Publications

Introduction: Prospective, real-world clinical studies of the association between skin color and pulse oximeter (SpO2) accuracy in children are needed to address the limitations of previous research. Such studies are essential for generating evidence for clinicians, regulators and industry. This is the protocol for a multisite study funded by the National Heart, Lung, and Blood Institute (R01HL171313; 1 January 2024-31 December 2028).

Methods and analysis: In this pragmatic, observational study conducted in three large paediatric cardiac catheterisation centres in the USA, children undergoing cardiac catheterisation with directly measured arterial oxygen saturation will be prospectively enrolled. The outcome variable (SpO2 bias) …


Training To Move An Evidence-Based Dementia Caregiver Support Program Into Practice: A Pragmatic, Randomized, Non-Inferiority Trial Protocol, Nancy A. Hodgson, Miranda V. Mcphillips, Karen B. Hirschman, Emily Summerhayes, Catherine Verrier Piersol, Laura N. Gitlin Apr 2025

Training To Move An Evidence-Based Dementia Caregiver Support Program Into Practice: A Pragmatic, Randomized, Non-Inferiority Trial Protocol, Nancy A. Hodgson, Miranda V. Mcphillips, Karen B. Hirschman, Emily Summerhayes, Catherine Verrier Piersol, Laura N. Gitlin

Department of Occupational Therapy Faculty Papers

Background

Despite over 200 evidence-based dementia caregiver programs, we know little about the best approaches for optimally scaling these programs in daily service contexts, nor do we fully understand the most effective approaches of ensuring successful implementation. As a result, a small fraction of the many individuals living with dementia and their caregivers within in the US have access to evidence-based programs. A leading barrier to implementation of evidence-based dementia caregiver support programs into long-term care settings is the lack of streamlined, scalable, user-friendly, and tested training modalities.

Objective

To describe the protocol for a study evaluating the implementation of …


Tobacco Smoke Exposure Is A Driver Of Altered Oxidative Stress Response And Immunity In Head And Neck Cancer, Yang Li, Pedram Yadollahi, Fonma N Essien, Vasanta Putluri, Chandra Shekar R Ambati, Abu Hena Mostafa Kamal, Lama M Abdurrahman, Maria E Ruiz Echartea, Keenan J Ernste, Akshar J Trivedi, Jonathan Vazquez-Perez, William H Hudson, William K Decker, Rutulkumar Patel, Abdullah A Osman, Farrah Kheradmand, Stephen Y Lai, Jeffrey N Myers, Heath D Skinner, Cristian Coarfa, Kwangwon Lee, Antrix Jain, Anna Malovannaya, Mitchell J Frederick, Vlad C Sandulache Apr 2025

Tobacco Smoke Exposure Is A Driver Of Altered Oxidative Stress Response And Immunity In Head And Neck Cancer, Yang Li, Pedram Yadollahi, Fonma N Essien, Vasanta Putluri, Chandra Shekar R Ambati, Abu Hena Mostafa Kamal, Lama M Abdurrahman, Maria E Ruiz Echartea, Keenan J Ernste, Akshar J Trivedi, Jonathan Vazquez-Perez, William H Hudson, William K Decker, Rutulkumar Patel, Abdullah A Osman, Farrah Kheradmand, Stephen Y Lai, Jeffrey N Myers, Heath D Skinner, Cristian Coarfa, Kwangwon Lee, Antrix Jain, Anna Malovannaya, Mitchell J Frederick, Vlad C Sandulache

Faculty, Staff and Student Publications

Background: Exposomes are critical drivers of carcinogenesis. However, how they modulate tumor behavior remains unclear. Extensive clinical data show cigarette smoke to be a key exposome that promotes aggressive tumors, higher rates of metastasis, reduced response to chemoradiotherapy, and suppressed anti-tumor immunity. We sought to determine whether smoke itself can modulate aggressive tumor behavior in head and neck squamous cell carcinoma (HNSCC) through reprogramming of the cellular reductive state.

Methods: Using established human and murine HNSCC cell lines and syngeneic mouse models, we utilized conventional western blotting, steady state and flux metabolomics, RNA sequencing, quantitative proteomics and flow cytometry to …


Acompañamiento And Assessment: Examples Of Community Building Through Assignments In A First-Year Class, Shaianne Tran, Hector Amezola, Dalissa Rodriguez, Morgan Baird, Jennifer Fuentes Luna, Alejandra Vazquez, Fattemah Zia, David Peterson Del Mar Apr 2025

Acompañamiento And Assessment: Examples Of Community Building Through Assignments In A First-Year Class, Shaianne Tran, Hector Amezola, Dalissa Rodriguez, Morgan Baird, Jennifer Fuentes Luna, Alejandra Vazquez, Fattemah Zia, David Peterson Del Mar

Amplify: A Journal of Writing-as-Activism

This collection of seven diverse assignments written by students from under-represented communities for a first-year inquiry class on immigration, migration, and belonging illustrates how instructors can facilitate a sense of belonging or acompañamiento through course assignments, assessment instruments. Each of the student authors provides a retrospective introduction on how their personal reflection, essay, or research project helped them to make personal connections within or outside of the class. The instructor provides a brief introduction to the concept of acompañamiento and why it is particularly important for New Majority college students.


Inciting Action By Analyzing Pachirat, Rhi N. Soto Apr 2025

Inciting Action By Analyzing Pachirat, Rhi N. Soto

Amplify: A Journal of Writing-as-Activism

The book Every Twelve Seconds: Industrialized Slaughter and the Politics of Sight by Timothy Pachirat explores “the politics of sight”, or the intentional invisibilizing or transparentizing of repugnant acts in order to encourage or limit them, through the case study of a beef slaughter house in Omaha, NE. While also utilizing the politics of sight, Pachirat hopes for great political and social change concerning the immoral acts that happen at meat plants through a radical act of transparency: a narrative ethnography. Writers with similar goals of great change in social and political issues can make use of Pachirat’s techniques, which …


Recognizing The Right To Care: A Key Step In Building The Care Economy, Valdrin Dragusha Apr 2025

Recognizing The Right To Care: A Key Step In Building The Care Economy, Valdrin Dragusha

Bridges: An Undergraduate Journal of Contemporary Connections

The care crisis stems from the social prescription of women as caregivers, leading to their overrepresentation in unpaid care work. Unpaid is linked to broader structural crises like economic inequality, poverty, and precarity, which are exacerbated by intersecting inequalities. The care crisis perpetuates women’s marginalization in economic and social spheres due to the invisibility of care work in the care economy. The care economy includes non-market and market-based care provision, involving public investments in social infrastructure and protection. According to the International Labour Organization, women perform 76.2% of all unpaid care work globally, dedicating 3.2 times more hours than men. …


The Impact Of Covid-19 On Nurses' Feelings, Stress, Coping, And Motivation In Palestinian Treatment Centers Of Corona, † Wafaa Menawi, Shatha Mari, Ahmad Adel Hanani Apr 2025

The Impact Of Covid-19 On Nurses' Feelings, Stress, Coping, And Motivation In Palestinian Treatment Centers Of Corona, † Wafaa Menawi, Shatha Mari, Ahmad Adel Hanani

An-Najah University Journal for Research - B (Humanities)

Background: Frontline nurses of COVID-19 found themselves in an unfamiliar new disease work environment, fighting to adapt and control the stress while working at covid-19 centers in Palestine. Aim: To investigate the impact of COVID-19 on nurses' feelings, stress, coping, and motivation in COVID-19 Palestinian treatment Centers. Method: A descriptive cross-sectional design was conducted between Mid of July to the end of October 2021 by recruiting a purposive sample of 390 nurses who worked at the Ministry of Health during COVID-19 pandemic treatment centers. The nurses filled out the COVID-19 Health Personnel Questionnaire with Cronbach's Alpha > 0.9. Results: Palestinian frontline …


The Student Movement Volume 109 Issue 19: Once Upon A Total Eclipse, Stripples Fall Victim To A Tariff Apocalypse, Gersh William, Marco Sciarabba, Ayanda Dewa, Aiko J. Ayala Rios, Melissa Moore, Andrew Francis, Finnegan Blake, Anna Rybachek Apr 2025

The Student Movement Volume 109 Issue 19: Once Upon A Total Eclipse, Stripples Fall Victim To A Tariff Apocalypse, Gersh William, Marco Sciarabba, Ayanda Dewa, Aiko J. Ayala Rios, Melissa Moore, Andrew Francis, Finnegan Blake, Anna Rybachek

The Student Movement V. 109 (2024-2025)

HUMANS

The Future of Dining? Bon Appétit Introduces AI-Powered Service, Gersh William

The Grimm's Briar Rose: An Honor Scholar's Thesis, Marco Sciarabba

Love Bridges All: Rec Center to Serve as Wedding Venue, Ayanda Dewa

ARTS & ENTERTAINMENT

Paradise Promised: University Choirs Celebrate Easter, Aiko J. Ayala Rios

NEWS

An AUSA Banquet Once Upon A Dream, Melissa Moore

Solar Skylarking: AU to Experience Total Eclipse Two Years in a Row, Melissa Moore

Hyve 2025 Conference Comes to Andrews University, Melissa Moore

IDEAS

Stripples Struck Down by New U.S. Tariffs, Andrew Francis and Finnegan Blake

PULSE

Are You Kidding Me? A Brief …


2025 Jsu Student Symposium Proceedings, Shannon Robertson Apr 2025

2025 Jsu Student Symposium Proceedings, Shannon Robertson

JSU Student Symposium 2025

No abstract provided.


Infographic: School Student Retention, Enrolments And Teacher Growth, Dominique Russell Apr 2025

Infographic: School Student Retention, Enrolments And Teacher Growth, Dominique Russell

Teacher infographics

The Australian Bureau of Statistics release data on schools, staff and students in Australia each year. The latest data for 2024 show increases from 2023 in student retention, full-time equivalent teaching staff, and student enrolment.


Workplace Isolation And Loneliness In School-Based Occupational Therapy Practitioners: A Cross-Sectional Study, Megan Ziff Otd, Otr/L, Amy Carroll Otd, Otr/L, Catherine V. Piersol Phd, Otr/L Apr 2025

Workplace Isolation And Loneliness In School-Based Occupational Therapy Practitioners: A Cross-Sectional Study, Megan Ziff Otd, Otr/L, Amy Carroll Otd, Otr/L, Catherine V. Piersol Phd, Otr/L

Department of Occupational Therapy Posters and Presentations

Introduction

  • Increasing “epidemic” of social isolation and loneliness in the United States
  • The workplace is one locale that can provide social connection1
  • School-based occupational therapy practitioners (SBOTPs) report feeling isolated in the workplace2
  • Lack of time can constrain development of collaborative relationships3
  • Contractors in particular report feeling on the outskirts of school team communication4
  • No prior study specific to SBOTP’s workplace isolation and loneliness

Purpose: Describe workplace isolation and workplace loneliness in SBOTPs; investigate their relationship to employment type, and indirect time.

Hypothesis 1: A weak-to-moderate positive relationship between workplace isolation and workplace loneliness in SBOTPs …


Analytics Without Borders Program Schedule, Bryant University Department Of Information Systems And Analytics Apr 2025

Analytics Without Borders Program Schedule, Bryant University Department Of Information Systems And Analytics

Analytics Without Borders

No abstract provided.


Application For Leave To File Amicus Curiae Brief In Support Of Petitioners; Amicus Curiae Brief, Myriam E. Gilles Apr 2025

Application For Leave To File Amicus Curiae Brief In Support Of Petitioners; Amicus Curiae Brief, Myriam E. Gilles

Amicus Briefs

Amici curiae are law professors who teach and write about the function and role of state and federal courts. Because Amici have substantial expertise in the history, practices, and workings of courts, Amici submit this brief in the hope of being of assistance to this Court in its deliberation.


Over Explaining Things Again: Poems, Emily Mckinney Apr 2025

Over Explaining Things Again: Poems, Emily Mckinney

Poetry MFA Theses

This thesis contains a collection of poems meditation on family, self, chronic illnesses, and the intersection of these themes. The collection seeks to question itself and make sense of personal history in its spiraling repetitions of subject that move from the abstract speaker into the concrete. The poems are accompanied by a critical essay.


The Process Is The Reform: Examining The Portrait Of A Learner In Nevada, Jeremy Adam Young Apr 2025

The Process Is The Reform: Examining The Portrait Of A Learner In Nevada, Jeremy Adam Young

Theses and Dissertations

To understand the process and substance of the Portrait of a Learner as an educational reform in Nevada through examining the experiences of individuals leading the initiative and to connect what is learned to educational reform in a larger context. A comprehensive literature review was cross-referenced with in-depth interview and focus group results from the Nevada Department of Education and two school districts. This qualitative study might be best described as a purposive, non-randomized study. Fifteen participants, including teachers, administrators, policymakers, and nonprofit professionals participated in interviews and/or focus groups, which were semi-structured. The data were analyzed and organized by …


Reconstruction From Variable Aperture Measurements Using Band-Limited Inversion Algorithms, Harrison C. Garrett Apr 2025

Reconstruction From Variable Aperture Measurements Using Band-Limited Inversion Algorithms, Harrison C. Garrett

Theses and Dissertations

The signal reconstruction process from discrete samples is inherently band-limited due to the limited amount of spectral content in the discrete set of measurements. In the case of 1D sampling using ideal measurements, the maximum bandwidth of regular and irregular sampling is well known using Nyquist and Gröchenig sampling theorems and lemmas, respectively. However, determining the appropriate reconstruction bandwidth becomes difficult when considering 2D sampling geometries, samples with variable apertures, or signal to noise ratio limitations. Instead of determining the maximum bandwidth a priori, this thesis introduces the use of a bandlimited inverse to simultaneously reconstruct a signal and determine …


Mysterious Munitions In Sleepy St. Pete: The Story Of A 1924 Filibustering Campaign, Arturo Sebastian Gonzalez Apr 2025

Mysterious Munitions In Sleepy St. Pete: The Story Of A 1924 Filibustering Campaign, Arturo Sebastian Gonzalez

Tampa Bay History

No abstract provided.


Work, War, Wit, Wisdom: Lessons And Legacies From Ybor City, Donna Piñero Parrino Apr 2025

Work, War, Wit, Wisdom: Lessons And Legacies From Ybor City, Donna Piñero Parrino

Tampa Bay History

No abstract provided.


Actions Speak Louder Than Words: Public Perceptions Of Victim Forgiveness And Offender Reparative Effort, Samantha Does Apr 2025

Actions Speak Louder Than Words: Public Perceptions Of Victim Forgiveness And Offender Reparative Effort, Samantha Does

Bridges: An Undergraduate Journal of Contemporary Connections

Passing judgment is an inevitable aspect of human behaviour, particularly in cases of severe wrongdoing or crime. These assessments can affect the individuals implicated in the transgressions, including the victim and offender. This research enhances our understanding of how third parties judge offenders and victims of crime, exploring whether offender participation in rehabilitation, offender remorsefulness, and the victim's forgiveness following a crime influence the third party's judgement of the victim and offender. Participants were presented with a scenario depicting a significant transgression, after which they responded to prompts concerning their perceptions of the event and the people involved. The findings …


Using Sound Change To Study Phonological Representations: The Case Of American English Diphthongs, Eitan Price Apr 2025

Using Sound Change To Study Phonological Representations: The Case Of American English Diphthongs, Eitan Price

Lawrence University Honors Projects

The question of diphthong phonematicity —do diphthongs consist of two monophthongs in one nucleus, or a single, dynamic vowel phoneme —is an important question when analyzing the phonemic inventory of a language with diphthongs. American English has a dearth of synchronic phenomena that could be used to test diphthong phonematicity, and phonetic studies have suffered from a lack of direct reference to phonological structures. This study takes a novel approach to diphthong phonematicity by examining the acoustic signature of American English sound changes. Specifically, it compares the vowels of speakers from the North and Midlands regions. When analyzed as biphonematic, …


The Diamond, April 4, 2025, Dordt University Apr 2025

The Diamond, April 4, 2025, Dordt University

Dordt Diamond

  • Front Page: Women's Basketball Wins Back-to-Back National Titles; A Closer Look at the Removal of Dordt's Ash Trees; The Non-Dutch, Non-Reformed Experience at Dordt
  • News: New Canadian Prime Minister; Faith CRC Hosts Community Worship Night
  • Feature: Dordt and Northwestern Social Work Clubs Support Sioux Center Families in Need; Senior Spotlight; NISO and Concert Choir Work with Community Members to Present Brahm's Requiem; Puppetry, Faith, and a Whimsical Life: Dordt Alumnus Story; Designing a Space for Community; Dordt University Introduces Innovative Gaming Course
  • Arts & Entertainment: It's Not That Deep: Senior Art Exhibit Showcase; Radium Girls …


Usa V. John Perkins Apr 2025

Usa V. John Perkins

2025 Decisions

USDC for the Eastern District of Pennsylvania


“They Are Fat And Want Special Treatment For Being Fat”: Backlash To And Lay Theories Of Fat Activism, Flora Blanchette-Oswald, Minh Duc Pham, R. J. Harr, Alexandra Garr-Schultz, Kimberly E. Chaney Apr 2025

“They Are Fat And Want Special Treatment For Being Fat”: Backlash To And Lay Theories Of Fat Activism, Flora Blanchette-Oswald, Minh Duc Pham, R. J. Harr, Alexandra Garr-Schultz, Kimberly E. Chaney

Faculty Publications

Fat activism is a movement that seeks to acknowledge and eliminate the oppression of fat people. The movement and those who participate face significant backlash, yet fat activism is understudied. We sought to understand lay theories about fat activism; that is, how everyday people think about the goals and motivations of fat activism, and people who engage in fat activism, to understand how these perceptions shape support for and backlash toward fat activism. In Study 1 (N = 294), we qualitatively elucidated lay theories of fat activism in a US nationally representative sample. We identified lay theories that both …


Addressing Hiv And Substance Use Health Disparities Among Racial/Ethnic Minority Individuals, Jamie V. Saunt, David L. Hussey Apr 2025

Addressing Hiv And Substance Use Health Disparities Among Racial/Ethnic Minority Individuals, Jamie V. Saunt, David L. Hussey

Faculty Scholarship

Purpose of Review: Advances in HIV testing, prevention, and treatment, alongside increased awareness and harm reduction efforts for substance use disorder (SUD) have improved care and treatment access over the past decade. However, racial and ethnic minorities with SUD and HIV or at risk for HIV still face disproportionately high health disparities. Understanding and addressing the reasons behind these disparities is crucial. Recent Findings: Structural and systemic barriers continue to negatively impact minoritized communities, due to lack of access to care, mistrust, and feelings of ostracization. Disconnected systems for HIV and SUD treatment complicate combined care. Delays in HIV diagnosis …


Social Belonging In Post-Resettlement Refugees: The Role Of Aid Organizations In The United States, Jessica Jean Byers Apr 2025

Social Belonging In Post-Resettlement Refugees: The Role Of Aid Organizations In The United States, Jessica Jean Byers

Theses and Dissertations

Since 1975, an estimated 3.6 million refugees have entered the United States (USA Facts, 2024). The months and even years following resettlement can be difficult and isolating for refugees. Previous research has shown that creating connections with others can enhance well-being, feelings of security, and self-reliance, all of which are especially needed for vulnerable populations such as refugees (Archambault et al., 2022; Giovanetti et al., 2022). Using the theory of social network analysis and semi-structured, in-depth interviews with aid organization leaders, this study seeks to understand the relationship between refugees and aid organizations during the post-resettlement phase. It also explores …


A Long Non-Coding Erna Forms R-Loops To Shape Emotional Experience-Induced Behavioral Adaptations, Rose Marie Akiki Apr 2025

A Long Non-Coding Erna Forms R-Loops To Shape Emotional Experience-Induced Behavioral Adaptations, Rose Marie Akiki

MUSC Theses and Dissertations

Emotional experiences often evoke neural plasticity that supports adaptive changes in behavior, including maladaptive plasticity associated with mood and substance use disorders. These adaptations are supported in part by experience-dependent activation of immediate-early response genes, such as Npas4. We discovered that a conserved, long non-coding enhancer RNA (lnc-eRNA) transcribed from an activity-sensitive enhancer produces DNA-RNA hybrid R-loop structures that support 3D chromatin-looping of the enhancer and proximal promoter and stimulus-induced, rapid Npas4 gene induction. We also show that this Npas4 lnceRNA and its R-loops are required for the development of behavioral adaptations produced by chronic psychosocial stress or cocaine exposure, …