Digital Commons Network^™

Gpat4 Sustains Endoplasmic Reticulum Homeostasis In Endocardial Cells And Safeguards Heart Development, Youjun Wang, Zhongzhou Yang

Faculty, Staff and Student Publications

The endocardium plays a pivotal role in governing myocardial development, and understanding the intrinsic regulatory insights will help apprehend pathological cardiomyopathy. Glycerol-3-phosphate acyltransferase 4 (GPAT4) is an endoplasmic reticulum (ER) membrane anchored protein. While the role of GPAT4 in glycerophospholipid biosynthesis is well established, its function in the ER is less explored. Here, we generate Gpat4 global and tissue-specific knockout mice and identify the essential role of GPAT4 in endocardial development. Deficiency of GPAT4 provokes endocardial ER stress response and enhances ER-mitochondrial (ER-mito) communications, leading to mitochondrial DNA (mtDNA) escape. As a result, the cGAS-STING pathway is triggered to stimulate …

Incorporating A Sustainable Eportfolio Model Within The Curriculum For Enhanced Professional Development: Building Bridges In Pharmacy Technician Education, Tao Zhang, Seána Hogan, Kathryn Young, Mary Therese Mcgrath, Jill Barrett, Julie Dunne

Research Outputs: 2025-Present

No abstract provided.

Open Accessarticle Crystal Plasticity Modeling Of Dislocation Density Evolution In Cellular Dislocation Structures, Md Mahabubur Rohoman, Caizhi Zhou

Faculty Publications

The complex thermal cycles during the solidification process in metal additive manufacturing (AM) lead to the formation of high-density dislocation networks, organizing into submicron-scale cellular structures. These ultrafine structures are recognized as crucial for enhancing the mechanical properties of AM metals. In this study, we investigate the evolution of dislocation density within these cellular structures under plastic deformation and its impact on mechanical response using dislocation density-based crystal plasticity finite element (CPFE) modeling. The model incorporates the evolution of both statistically stored dislocation (SSD) and geometrically necessary dislocation (GND). Our simulations reveal that the yield and flow stresses of dislocation …

Differential Antibody Response To Ebv Proteome Following Ebvst Immunotherapy In Ebv-Associated Lymphomas, Helen E Heslop, Rayne H Rouce, Anna E Coghill, Cliona M Rooney, Carla Proietti, Denise L Doolan

Faculty, Staff and Students Publications

Epstein-Barr virus (EBV) is associated with a diverse range of lymphomas. EBV-specific T-cell (EBVST) infusions have shown promise in safety and clinical effectiveness in treating EBV-associated lymphomas; however, not all patients respond to T-cell immunotherapies. To identify EBV antigen–specific antibody responses associated with clinical outcomes, we comprehensively characterized antibody responses to the complete EBV proteome using a custom protein microarray in 56 patients with EBV-associated lymphoma who received EBVST infusions in phase 1 clinical trials. Responders (nonprogressors) and nonresponders (progressors) had distinct antibody profiles against EBV. Twenty-five immunoglobulin G (IgG) antibodies were significantly elevated in higher levels in nonresponders than …

Tumor-Derived Arachidonic Acid Reprograms Neutrophils To Promote Immune Suppression And Therapy Resistance In Triple-Negative Breast Cancer, Fengshuo Liu, Zhan Xu, Xiaoxin Hao, Ling Wu, Weijie Zhang, Hilda L Chan, Bo Wei, Philip L Lorenzi, Yang Gao, Igor Bado, Luis Becerra-Dominguez, Charlotte Helena Rivas, Sergio Aguirre, Bradley C Pingel, Yi-Hsuan Wu, Yunfeng Ding, Jun Liu, David G Edwards, Livia S Eberlin, Xiang H-F Zhang

Faculty, Staff and Students Publications

The combination of immune checkpoint blockade and chemotherapies is the standard of care for triple-negative breast cancer (TNBC). However, initially, responsive tumors can still develop recurrences, suggesting acquired resistance mechanisms that remain poorly understood. Herein, we discover that TNBC cells surviving anti-programmed cell death protein-1 (anti-PD-1) and chemotherapy treatment accumulate neutral lipids. Disrupting lipid droplet formation in cancer cells reverses resistance and mitigates the immunosuppressive microenvironment. Single-cell RNA sequencing reveals a subset of neutrophils exhibiting a lipid-laden phenotype similar to adjacent tumor cells. Mechanistically, tumor-derived extracellular vesicles carrying lipids, including arachidonic acid (AA), mediate neutrophil reprogramming. Blocking dietary intake of …

84 - Effect Of Organized Sport Interventions On Motor Outcomes Of Children With Autism Spectrum Disorder - A Systematic Review., Maeren Hill, Kailash Ram, Caitlyn Warnock, Kaitlin Hardy, Sonia Khurana, Pt, Ph.D.

Undergraduate Research Symposium

Aim:

The aim of this systematic review was to synthesize randomized clinical trials to evaluate the effectiveness of sports-based interventions on motor outcomes in children with autism spectrum disorder (ASD).

Methods:

A comprehensive literature search was conducted on the following five databases from inception to November 2024: PubMed, Web of Science, CINAHL, Cochrane Library, and Clinical Trials. Gray literature was sourced from Google Scholar and ProQuest Dissertations and Theses.

Articles were eligible for inclusion if they met the following criteria: (1) published in English; (2) participants were under the age of 18 with a diagnosis of ASD; (3) interventions consisted …

70 - Unmeasured Confounding In Meta-Analyses Of Observational Studies Evaluating Maternal Periodontitis And Adverse Birth Outcomes, May Salama, Abdullah Al-Taiar, Denise Claiborne, Anwar Merchant

Undergraduate Research Symposium

Background: Maternal periodontitis has been consistently linked to adverse birth outcomes (ABOs). However, a causal relationship is not established due to potential unmeasured confounding factors in observational studies and inconclusive results from randomized controlled trials. This study aimed to assess the impact of unmeasured confounding factors in meta-analyses examining associations between maternal periodontitis and preterm birth (PTB) or low birth weight (LBW).

Methods: PubMed and MEDLINE, Cochrane, Embase, and Google Scholar were searched for systematic reviews with meta-analyses of observational studies between 2002 and 2023. Systematic reviews with meta-analyses of observational studies were included if either PTB or LBW were …

The Role Of Capital On Literacy And Second Language Acquisition: A Cross-National Comparative Study, Brenda Koumondji

INSPIRE Student Research and Engagement Conference

Key Context:

• Globalization has increased the demand for multilingual skills.
• Yet, language learning opportunities vary based on national education policies and socioeconomic factors.
• Language learning opportunities are shaped by social structures and vary based on economic,social, and cultural capital (ESC) (Bourdieu, 1986).

Second Language Benefits

• Economic (Brown & Lauder, 1991; Foreman-Peck & Wang, 2014)
• Cognitive and Psychological (Bialystok, 2011; Dewaele & Wei, 2012; Graham, 2017)
• Social and Cultural (Marboua et al., 2024)

Research Focus:

• Cross-national comparison of South Korea, Norway, Chile, and the U.S.

A Systematic Review Of Cultural And Structural Barriers To Mammogram Access Among Immigrant Women, Abeer Wael Abukamil, Samar Ghassan Chehab, Sabrina Khan, Rima Charara

Medical Student Research Symposium

Introduction:

Mammograms are crucial for early breast cancer detection and reducing mortality (5). However, U.S. minorities, particularly immigrants, are less likely to receive screenings (9). Identifying barriers can help tailor interventions to meet immigrant women’s needs.

Methods:

Studies were found on PubMed using a systematic review protocol following PRISMA guidelines (8). Search terms included “minority,” “mammograms,” and “barriers.” Articles were then selected for a full-text review by three authors. 220 articles were narrowed down to 7 by relevance and date of publishing (2005 and beyond).

Results:

Cultural barriers often limit immigrant women’s access to breast cancer screenings. In certain non-Western …

The Influence Of Field Experiences On English Language Teachers' Preparedness: An Analysis Of Teacher Education In Nigeria, Bushroh O. Animashaun

INSPIRE Student Research and Engagement Conference

Brief Context:

• Definition of key terms: teacher education, field experiences.
• Importance of teacher education in language education
• Challenges in the Nigerian education system
• Why focus on teacher education?

Why Top-Two Primaries Can't Be Fixed, Quinn Yeargain

Fordham Law Voting Rights and Democracy Forum

No abstract provided.

Ole Miss Giving Day Set For April 8-9, Rebecca Lauck Cleary

Blog Posts

The University of Mississippi will host its sixth annual Giving Day on April 8 and 9. We hope you consider supporting the Center for the Study of Southern Culture. You can donate to the Center for the Study of Southern Culture and specify how your funds should be used, or consider contributing to these two specific challenges that will unlock a gift.

Inspire Student Research & Engagement Conference [Program] April 7-8, 2025, University Of Northern Iowa

INSPIRE Student Research & Engagement Conference Programs

A program for the INSPIRE conference where undergraduate and graduate students present their research, internship, volunteer and study abroad experiences, club activities and creative performances.

A Pilot Study On Tailored Dynamic Written Corrective Feedback For High School Chinese Language Learners, Cilei Han

Doctor of Education (EdD)

Despite a significant increase in global efforts to teach and learn Chinese as a foreign language (CFL) in recent decades (Center for Applied Second Language Studies, 2010), past research reveals that CFL learners face greater challenges in writing than their peers studying AP1 Spanish, French, and German, underscoring the need for targeted writing support at the high school intermediate level (College Board, 2025). To address the gap, this mixed-methods study tailored Dynamic Written Corrective Feedback (DWCF), originally designed for college English (as a second language, ESL) writing courses, to high school intermediate CFL learners. Participants included Level IV students (n …

Dollars And Zen: A Randomized Control Trial Of A Community-Partnered Financial Capability And Stress Management Digital Intervention Among Low-Income Latino Adults, Luisa Blanco, Nataria Joseph, Mckenzie Richards, Flora Sedrakyan

School of Public Policy Working Papers

Latino adults disproportionately experience financial stress, but no programs developed for Latinos comprehensively and successfully integrate financial capability and stress management approaches to address financial stress. Using a community-partnered approach, we enhanced a digital financial capability intervention with theoretically- and empirically-grounded stress management techniques. We tested whether this integrative intervention improved financial capability, self-efficacy, actions, and stress as well as sleep, a correlate of stress. A sample of 76 Latino adults (39 in the intervention group, 37 in the control group; mean age = 45, 76% female, 88% with household income below $59,999) completed the three-month randomized waitlist-control trial. Participants …

Short-Term Study Abroad Programs: A Sustainable Model For Community Colleges, Jorge Grajales-Díaz

Inquiry: The Journal of the Virginia Community Colleges

This study employed qualitative methods to explore how the UVA in Valencia Summer Program 2019/ 2021 approached instructional practices (e.g., in-class and out-of-class immersive learning activities, homestays, pre-program services, including use of L2 and culture learning strategies) to identify those features of the program design that Piedmont Virginia Community College (PVCC) could reproduce in a new short-term study abroad designed to expand its students’ oral proficiency and cultural awareness. The study used data from Zoom interviews with faculty, administrators, and L2 participating students. The findings address the study’s purpose in describing how the UVA in Valencia Summer Program 2019/ 2021 …

Ai Beliefs And Practices In Community College Classrooms, Julie Eng, Heather Umphlett, Jocelyn Gilchrist, Alicia Howell, Mary Ann Howell, Wendy Miller-Edwards, Laurel Pope

Inquiry: The Journal of the Virginia Community Colleges

The country, the Commonwealth of Virginia, and Virginia Community College System initiatives all promote generative AI within education. It is a topic of great concern and interest for higher education instructors, yet at the same time many faculty members feel uncertain about effectively integrating it into class material. To further add pressure to the AI explosion, community colleges particularly face a responsibility to prepare their students for success in this new AI-focused environment. In this article, seven faculty members from Camp Community College discuss the implications of generative AI programs, including subscriptions and chatbots, within their particular courses and how …

The Impact Of Dual Enrollment On Educational Aspirations Of Traditionally Underrepresented Students In Community College, Wayne Carter, Carol Gruber

Inquiry: The Journal of the Virginia Community Colleges

This research study examined the difference in academic motivation and academic self-efficacy of traditionally underrepresented students in community college who previously participated in high school dual enrollment programs versus their comparable peers without dual enrollment experience. This is important given the socio-economic disparities between the various student groups participating in this selective college preparatory program. Historically, traditionally underrepresented students have yet to participate in dual enrollment programs commensurate with their non-minority and affluent peers. By examining the difference between these two specific student subgroups, the researchers addressed what types of motivation and self-efficacious behaviors affected these college students who opted …

Ai Isn’T What We Should Be Worried About – It’S The Humans Controlling It, Billy J. Stratton

English and Literary Arts: Faculty Scholarship

Stratton examines depictions of AI in popular media and literature, drawing comparisons to real-world AI and humanity's capacity to harness technology for good or ill.

Exploring Credit Loss For Engineering Transfer Students, Amy J. Richardson, David B. Knight

Inquiry: The Journal of the Virginia Community Colleges

One of the issues at the heart of transfer is the mobility of credits across institutions—moving credits from one institution to another is a crucial process for the transfer pathway to be a viable option. Credit loss is a critical issue for transfer students enrolled in highly sequential degrees, such as engineering. A student could be set back a year or more if they miss one required prerequisite course at the time of transfer. Determining who experiences credit loss in engineering could help ease the transfer process, improve graduation rates, and broaden participation in engineering since the transfer pathway has …

Characterizing Stroke Presenting To A Regional Referral Hospital Before And During The Covid-19 Pandemic In Uganda: A Retrospective Analysis, Christopher Burant, Shirley Moore, Martha Sajatovic

Faculty Scholarship

Introduction: Stroke, a leading cause of global morbidity and mortality, disproportionately impacts low and middle-income countries, particularly in sub-Saharan Africa (SSA) which reports the highest stroke burden. The COVID-19 pandemic further complicated this situation, emerging as a significant stroke risk factor. The pandemic also disrupted healthcare systems worldwide, affecting stroke management and care accessibility, and leading to deteriorated conditions in stroke patients upon hospital admission. In this pre/during COVID-19 pandemic analysis of acute stroke cases presenting to a Ugandan hospital, we investigated the relationship between stroke admissions, management and treatment outcomes. Methods: This was a retrospective medical record review in …

Gardner-Webb Team Answers Call To Help Neighbors In Western North Carolina, Office Of University Communications

Gardner-Webb NewsCenter Archive

Over the years, the Gardner-Webb Office of Christian Life and Service has led student mission teams to serve around the world and other parts of the United States. This year, some of the greatest needs were close to home, just over an hour from campus.

Rotunda - Vol 104, No 6 - Apr 7, 2025, Longwood University

Rotunda

No abstract provided.

Daily Acute Intermittent Hypoxia Elicits Age & Sex-Dependent Changes In Molecules Regulating Phrenic Motor Plasticity, Jayakrishnan Nair, Alexandria Marciante, Carter Lurk, Mia Kelly, Maclain Capron, Gordon Mitchell

Department of Physical Therapy Faculty Papers

Acute intermittent hypoxia (AIH) elicits a form of respiratory motor plasticity known as phrenic long-term facilitation (pLTF). Exposure to repetitive daily AIH (dAIH) enhances pLTF, a form of metaplasticity. Little is known concerning cellular mechanisms giving rise to dAIH-induced metaplasticity and the age-dependent sexual dimorphism of AIH associated pro-plasticity mRNA expression. To test if age, sex, and dAIH effects are associated with differential expression of molecules that regulate the Q- and S-pathways and their cross-talk interactions to phrenic motor facilitation, we analyzed key regulatory molecules in ventral spinal (C3-C5) homogenates from young (3-month) and middle-aged (12-month) male and female Sprague-Dawley …

A Multimethod Study Of The Impact Of Nudge Letters On Middle School Students’ Attendance, Kaila M. Wilson

Doctor of Education (EdD)

The purpose of this study was to increase parent involvement by using nudge theory to increase students’ overall attendance. This study addressed the issue of chronic absenteeism in K–12 schools in the current landscape of post-COVID-19 global pandemic where absenteeism has remained a persistent problem in Oregon. Chronic absenteeism affects student academics, behavior, and socioemotional well-being, displaying the importance of schools increasing their communication efforts with families. Attendance interventions have been used, but chronic absenteeism has remained at high levels postpandemic. Using nudge letters as an intervention is limited yet has proven to be effective in some schools in the …

Achieving Periodontal Disease Stabilization: Assessing The Impact Of Laser Therapy In Scaling And Root Planing And Periodontal Maintenance Visits, Cassandra Charlotte Cooper

Dental Hygiene ETDs

Purpose: This study examined the effectiveness of laser utilization in stabilizing periodontal disease over a one-year period. This research focused on the results following scaling and root planing with adjunctive laser-assisted periodontal therapy and laser bacterial reduction at subsequent periodontal maintenance visits. While short-term advantages are documented in the literature, research on sustained effectiveness is limited. Methods: A retrospective chart review of 30 adult patients who received the above treatment was conducted. Periodontal charting was recorded at three visits over one year. Data was collected and analyzed utilizing Statistical Package for Social Sciences (SPSS) to determine statistical significance of periodontal …

Vestibular Neurons Link Motion Sickness, Behavioural Thermoregulation And Metabolic Balance In Mice, Longlong Tu, Xing Fang, Yongjie Yang, Meng Yu, Hailan Liu, Hesong Liu, Na Yin, Jonathan C Bean, Kristine M Conde, Mengjie Wang, Yongxiang Li, Olivia Z Ginnard, Qingzhuo Liu, Yuhan Shi, Junying Han, Yi Zhu, Makoto Fukuda, Qingchun Tong, Benjamin Arenkiel, Mingshan Xue, Yang He, Chunmei Wang, Yong Xu

Children’s Nutrition Research Center Staff Publications

Motion sickness is associated with thermoregulation and metabolic control, but the underlying neural circuitry remains largely unknown. Here we show that neurons in the medial vestibular nuclei parvocellular part (MVePC) mediate the hypothermic responses induced by motion. Reactivation of motion-sensitive MVePC neurons recapitulates motion sickness in mice. We show that motion-activated neurons in the MVePC are glutamatergic (MVePCGlu), and that optogenetic stimulation of MVePCGlu neurons mimics motion-induced hypothermia by signalling to the lateral parabrachial nucleus (LPBN). Acute inhibition of MVePC-LPBN circuitry abrogates motion-induced hypothermia. Finally, we show that chronic inhibition of MVePCGlu neurons prevents diet-induced obesity and improves glucose homeostasis …

Predictors Of Political Participation Of U.S. Social Workers: The Mediating Effect Of Confidence, Maria Wathen, Rachel A. Young, Amy Krings, Teresa Kilbane

Social Work: School of Social Work Faculty Publications and Other Works

What factors are associated with social workers’ political participation, and how does political confidence mediate those relationships? To answer this question, data were collected in 2020 through an original online survey of members of the U.S.-based National Association of Social Workers (NASW). Informed by self-efficacy theory, researchers conducted a structural equation modeling (SEM) path model with political participation as the outcome variable, and political confidence as a mediating variable. Exogenous variables included: one’s self-reported political orientation, belief that social work has a political mandate, gender, and knowledge about how to effectively participate in politics. Results indicate that high political confidence …

The Role Of The Church In The German Democratic Republic: Examining The Representation Of Christianity In The Novel Einer Trage Des Anderen Last Within Its Cultural And Historical Context, Arden Remnant Gewirtz Levine

Foreign Languages & Literatures ETDs

The attitude towards the Protestant Church in the German Democratic Republic (GDR) changed overtime and was not homogenous during the approximately forty years of the GDR’s existence. This thesis will use this established cultural and historical context in order to analyze the representation of Christianity in the novel Einer trage des anderen Last, written by Wolfgang Held. The premise of the novel is two men diagnosed with tuberculosis are forced to share a room in the Sanatorium, however, one is a protestant pastor and the other is a member of the Volkspolizei (the People’s police). Through their distinct ideologies …

The Impact Of Perceived Discrimination On Mental And Physical Health Among The Hispanic Immigrant Population, Cheyla Tabares Cuesta

Undergraduate Theses

Discrimination has profoundly shaped the lives of individuals within disadvantaged communities, but its impact on mental and physical health has often been overlooked. In this project, I review literature on perceived discrimination based on immigrant status and its effects on psychological and physical health and examine a potential mediator and moderator of these relationships. Specifically, the relationships between immigration-based discrimination and both mental health and physical health may be mediated by perceived stress, meaning that discrimination may lead to higher stress levels, which results in poorer health outcomes. Furthermore, these relationships may be moderated by psychological resilience; individuals with higher …