Digital Commons Network^™

Unraveling Heart Failure Phenotypes: A Systematic Review And Meta-Analysis Of Peak Oxygen Uptake And Its Determinants, Corey R Tomczak, Stephen J Foulkes, Christopher Weinkauf, Devyn Walesiak, Jing Wang, Veronika Schmid, Sarah Paterson, Wesley J Tucker, Michael D Nelson, Simon Wernhart, Jan Vontobel, David Niederseer, Mark J Haykowsky

Faculty, Staff and Student Publications

Background: Understanding the impact of heart failure (HF) phenotype on peak oxygen uptake (peak ˙V O2) is essential for advancing personalized treatment strategies and enhancing patient outcomes. Therefore, we conducted a systematic review and meta-analysis of the evidence examining differences in peak ˙V O2 (primary objective) and its determinants (secondary objectives) between patients with HF with reduced (HFrEF) or preserved ejection fraction (HFpEF).

Methods: Studies comparing peak ˙V O2 in HFrEF vs HFpEF were found through PubMed (1967-2024), Scopus (1981-2024), and Web of Science (1985-2024). Data extraction and methodologic quality assessment were completed by 2 independent coders. Differences between HFrEF …

Lesion Classification By Model-Based Feature Extraction: A Differential Affine Invariant Model Of Soft Tissue Elasticity In Ct Images, Weiguo Cao, Marc J Pomeroy, Zhengrong Liang, Yongfeng Gao, Yongyi Shi, Jiaxing Tan, Fangfang Han, Jing Wang, Jianhua Ma, Hongbin Lu, Almas F Abbasi, Perry J Pickhardt

Faculty, Staff and Student Publications

The elasticity of soft tissues has been widely considered a characteristic property for differentiation of healthy and lesions and, therefore, motivated the development of several elasticity imaging modalities, for example, ultrasound elastography, magnetic resonance elastography, and optical coherence elastography to directly measure the tissue elasticity. This paper proposes an alternative approach of modeling the elasticity for prior knowledge-based extraction of tissue elastic characteristic features for machine learning (ML) lesion classification using computed tomography (CT) imaging modality. The model describes a dynamic non-rigid (or elastic) soft tissue deformation in differential manifold to mimic the tissues’ elasticity under wave fluctuation in vivo. …

Il13rα2-Targeting Antibodies For Immuno-Pet In Solid Malignancies, Leah Gajecki, Irina V Lebedeva, Yu-Rou Liao, Daisy Ambriz, Lukas M Carter, Melina Kumpf, Samantha Lovibond, Justin S Hachey, Maya S Graham, Michael Postow, Jason S Lewis, David P Andrew, Manuel Baca, Heiko Schöder, Steven M Larson, Darren R Veach, Simone Krebs

Faculty, Staff and Student Publications

Interleukin-13 receptor α-2 (IL13Rα2) is a cell surface receptor frequently expressed in solid malignancies, such as glioblastoma and melanoma, with limited expression in healthy tissue, rendering it an ideal target for noninvasive and specific tumor delineation. In this study, we report the development of 5 novel IL13Rα2-targeted human monoclonal antibodies (mAbs) KLG-1-5; in subsequent in vitro and in vivo studies after radiolabeling with 89Zr, we evaluate their performance to identify a lead candidate.

Methods: Five novel human anti-IL13Rα2 mAbs KLG-1-5 were developed and in vitro binding properties and target specificity assessed. In vivo 89Zr-immuno-PET using KLG-1-5 was conducted in a …

Correction To: Selinexor In Combination With Carboplatin And Paclitaxel In Patients With Advanced Solid Tumors: Results Of A Single-Center, Multi-Arm Phase Ib Study, Kyaw Z Thein, Daniel D Karp, Apostolia Tsimberidou, Jing Gong, Selma Sulovic, Jatin Shah, Denái R Milton, David S Hong, Filip Janku, Lacey Mcquinn, Bettzy A Stephen, Rivka Colen, Brett W Carter, Timothy A Yap, Sarina A Piha-Paul, Siqing Fu, Funda Meric-Bernstam, Aung Naing

Faculty, Staff and Student Publications

No abstract provided.

Piecing Together The Past: Documenting The Philanthropic History Of Lincoln’S Arts And Culture, Audrey L. Ellis

Honors Program: Senior Projects (Public)

This project explores the creation of a book chapter discussing the history of philanthropy in Lincoln, Nebraska, focusing on its impact on arts and culture. The chapter will be published in Fall 2025 by the Lincoln Community Foundation. By documenting philanthropy in the arts and culture spaces, this book and chapter hope to inspire further giving by showcasing the benefit that has been reaped through giving. Through research of public records and a series of interviews, this chapter examines Lincoln’s key donors and arts organizations from the mid-19th century to the present. This project explores the process and key takeaways …

Phi 243 Early Modern Philosophy, Naomi Zack Phd

Open Educational Resources

This course will introduce the student to key authors and texts in the history of modern western philosophy, from the 17^th and 18^th centuries--Descartes, Locke, Berkeley, and Hume. The focus will be on metaphysics (what exists) and epistemology (how we know, what knowledge is and what we know); universal human identity (what am I? and what makes me the same person?); what some philosophers thought the role of God is in metaphysics and epistemology. Included will be historical contexts of the philosophers studied, and their religious claims.

Psy 321 The Psychology Of Immigration And Acculturation Syllabus, Marjorine Henriquez-Castillo

Open Educational Resources

This course is all about understanding how immigration (moving to a new country) and acculturation (adapting to a different culture) shape who we are. Together, we’ll explore the history, theories, policies, and research surrounding these processes, focusing on how they influence the physical and mental development of individuals and communities in the U.S. By the end of the course, you’ll have a deeper understanding of how these experiences impact both you and the world around you.

Age-Associated Proteins Explain The Role Of Medial Temporal Lobe Networks In Alzheimer’S Disease, Adam Turnbull, Yejin Kim, Kai Zhang, Xiaoqian Jiang, Zihuai He, Victor W Henderson, F Vankee Lin

Faculty, Staff and Student Publications

The structural connectivity (SC) of the medial temporal lobe and its associated cortical anterior temporal and posterior medial networks (MTL-AT-PM) is linked to pathologies and memory decline in Alzheimer's disease (AD). However, neuroimaging analyses cannot tell us how SC changes occur in AD at the molecular level and do not provide a means of intervening to slow/prevent pathology-related changes in MTL-AT-PM SC. The current study aimed to understand how and where AD-related changes occur within MTL-AT-PM using proteomics. We used a 4-step approach in 101 older adults from a local sample, aiming to understand how proteins and SC in combination …

On The Provenance Of Software Systems: Automating Software Traceability With Knowledge Graph And Large Language Model Synergy, Tyler Procko

Doctoral Dissertations and Master's Theses

The present dissertation delineates a system that enables those engaged in software development to automatically generate and maintain project life cycle provenance. All projects are implemented and made manifest with the development of artifacts, e.g., papers, code files, etc. Tools exist to accelerate artifact creation, but little focus is paid to the processes that produce them. In terms of Ontology, or, from Ancient Greek, the study of being, the two most basic entities in reality are Continuant and Occurrent, or, roughly, “Artifact” and “Process”. This dissertation posits that for any created artifact, its process of creation, i.e., its life …

For The Birds, Charlotte L. Middleton

School of Art, Art History, and Design: Theses and Student Creative Work

For the Birds is a homogenous material exhibition of porcelain pottery that explores the relationships between, expectations of, and roles placed upon women and pottery. Using traditional craft processes, still life imagery, and the language and limits of porcelain, I create arrangements that expose the viewers assumptions of both subjects. Pottery- pitchers, cups, and vases—is a product of anthropocentrism and anthropomorphism and can be entirely taken for granted- their role is assumed and unquestionable—to serve. The language and expectations of these objects are the medium I build with.

The title of the show, For the Birds, is both a …

Ethical Ai Use And Classroom Integration Training Modules, Daniel Boudon

Open Educational Resources

This project focuses on developing comprehensive training modules to equip students and faculty with the knowledge and skills necessary to ethically and effectively use AI tools in academic settings. The training consists of interconnected modules that cover a wide range of topics, including the ethical use of AI, evaluating AI-generated content, integrating AI tools into curriculum design, and creating AI-enhanced classroom activities. Additional modules emphasize fostering digital literacy, staying updated with AI advancements, and collaborating on best practices for AI in education.

Designed for flexibility, the modules cater to diverse academic disciplines, making them suitable for undergraduate and graduate courses, …

Textual Transformations: An Introduction To Ai For Composition 101, J. Elizabeth Clark

Open Educational Resources

This curriculum unit is a critical literacy unit about AI designed for first-year writing. The introductory composition course prepares students for academic writing with a heavy emphasis on writing-as-process, critical reading, gathering information, inquiry-based writing, and taking research notes. This curriculum unit pairs the writing portion of the course with an AI critical literacy framework for students.

This is a 20-hour, 9 lesson unit designed for an introductory composition course:

• Prepwork: Preliminary Assessment and AI Policies

• Lesson 1: What is AI?

• Lesson 2: The History of AI

• Lesson 3: How Does AI Work?

• Lesson 4: AI in Action

• Lesson 5: …

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Adorning Harmony: Comparing Three Of Rachmaninoff’S Piano Transcriptions With The Original Works, Micah Robert Leary

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Sergei Rachmaninoff’s piano transcriptions represent an underperformed genre among his works. They offer a unique perspective on Rachmaninoff’s compositional language because they directly compare to other composer’s original works. Much research is dedicated to understanding Rachmaninoff’s harmonic language through analysis of his own original works. However, very little has been written on Rachmaninoff’s piano transcriptions, and no studies focus on Rachmaninoff’s harmonic language displayed in the transcriptions.

The following analysis aims to reconsider three of these lesser-known works and provide context for their placement alongside Rachmaninoff’s other compositions. Harmonic analysis provides insights relative to the original works within the larger …

Traumatic Brain Injury And Substance Use Disorder: A Clinic Based Exploratory Study, Steven Daniel Wheeler, Amanda Acord-Vira, Cecelia Simons, Kaleigh Papez, Jeremy Dixon, Cortland Nesley

Graduate Student Scholarship

Background: Traumatic brain injury (TBI) and substance use disorders (SUD) are common co-occurring conditions that have been investigated in isolation over the past several decades. Research regarding the conditions in unison have yielded conflicting results; however, there is a clear correlation linking negative implications of one condition on the other.

Objectives: To explore factors contributing to SUD among persons screening positive for a history of TBI and to validate the importance of screening for TBI as part of the SUD treatment program intake process.

Setting: Outpatient SUD treatment programs across West Virginia.

Design: Exploratory Study.

Methods: Those who screened positive …

Do Bank Ceos Learn From Crisis Experiences?, Gloria Yang Yu

Research Collection Lee Kong Chian School Of Business

Does the early-career exposure of bank CEOs to the 1980s savings and loans (S&L) crisis affect the outcomes of banks they subsequently managed? We measure the S&L crisis exposure by the bank failure rate in the states where CEOs worked during the S&L crisis. Armed with this measure, we find that banks managed by CEOs with higher S&L crisis exposure took on less risk and that these banks better survived the financial crisis of 2008. In particular, CEOs adjusted risk attitudes in areas causing the S&L crisis: their more intense crisis experience reduced banks’ interest rate risk, exposure to risky …

From Hanging To Nitrogen Hypoxia: The Evolution Of Execution And The Case For American Abolition, Anna Kuhlman

The International Law Review Association Student Forum

The death penalty has been a dark fixture in societal punishment for most of human history. It has allowed for grisly, violent executions of people found guilty of misconduct relative to the culture they live in. “The first established death penalty laws date as far back as the Eighteenth Century BCE in the Code of King Hammurabi of Babylon, which codified the death penalty for 25 different crimes.” The first death sentence on record was a member of nobility in 16th-century BCE Egypt, where the wrongdoer was accused of magic and ordered to commit suicide. In the seventh century B.C.E., …

Comparison Of Six Handheld Ultrasound Devices By Pediatric Point Of Care Ultrasound (Pocus) Experts, Stephanie K Leung, Ria Dancel, Riya N Soni, Ariadna Perez-Sanchez, Michael J Mader, Haitham Al-Wahab, Thomas W Conlon, Maria V Fraga, Javier J Lasa, Andrea Matho, Hannah Smith, Nilam J Soni

Faculty, Staff and Student Publications

BACKGROUND: Point of care ultrasound (POCUS) use is increasing among pediatric clinicians, but lack of access to ultrasound devices is a major barrier. The availability of pocket-sized handheld ultrasound devices ("handhelds") has improved access. However, no head-to-head comparative studies of handhelds in children have been performed to guide purchasing decisions.

METHODS: This cross-sectional study compared six handhelds: Butterfly iQ+™ (Butterfly Network Inc.), Clarius® (Clarius Mobile Health™), Kosmos™(EchoNous), TE Air™ (Mindray®), Vscan Air™ SL (General Electric), and Lumify™ (Philips Healthcare). Eight pediatric POCUS experts acquired views showing the abdominal right upper quadrant (RUQ), cardiac apical 4-chamber, and superficial neck and lung …

Evaluating The Human Abuse Potential Of Concurrent Use Of Electronic Cigarettes And Low Nicotine Cigarettes Among Adults Who Smoke, Jason D Robinson, Yong Cui, George Kypriotakis, Jeffrey M Engelmann, Maher Karam-Hage, Jennifer A Minnix, Charles E Green, Sanjay Shete, Dorothy K Hatsukami, Eric C Donny, Sharon E Murphy, Stephen S Hecht, Thomas Eissenberg, David W Wetter, Paul M Cinciripini

Faculty, Staff and Student Publications

The U.S. Food and Drug Administration has stated its intention to reduce the nicotine content of combustible cigarettes to render them less addictive. This study evaluated the impact of providing adults who smoke with both very low nicotine content cigarettes (VLNCCs) and electronic cigarettes (ECs) of varying nicotine content on measures of human abuse potential. Participants (

The Characteristics Of Missionary Understanding And Practices And The Impact Of Transnationalism In Reference To The Indian Pentecostal Church Of God (Ipc) In The Us, Jaewoo Joung

ATS Dissertations

No abstract provided.

Convention On Safety For Survivors Of Family Violence Involved In International Custody Disputes, Merle H. Weiner

Cardozo Law Review

This Article proposes a new treaty to fix the "domestic violence problem" that plagues the Hague Convention on the Civil Aspects of International Child Abduction. It argues that a new international instrument is legally permissible and would be the most efficient way to solve the problem. It compares the proposed solution to other child abduction instruments that exist in the European Union (EU) and Latin America but that do not address domestic violence. This Article proposes specific treaty provisions and provides commentary on those provisions. This Article is intended to influence state parties to the Hague Abduction Convention who are …

The Creation Of Gender In Conlangs, Alexis L. Campos, Ixchel Mireles, Bryon Haynes, David Kamal, Zachariah Gonzalez

Team - Mere Wudu - Documents

This PowerPoint presentation is an example of grammatical gender and language structure in the world of Mere Wudu using the language of "Letic"

Mere Wudu Legend, Alexis L. Campos, Ixchel Mireles, Bryon Haynes, David Kamal, Zachariah Gonzalez

Team - Mere Wudu - Documents

A story written in Ietic that discusses climate change and how it has impacted our society and land. An English version, Ietic version and a version written in our own alphabet is provided

Mere Wudu Semantics And Pragmatics, Alexis L. Campos, Ixchel Mireles, Bryon Haynes, David Kamal, Zachariah Gonzalez

Team - Mere Wudu - Documents

The Semantics and Pragmatics of our language. Descriptions and explanations of our religious and cultural values and beliefs.

Mere Wudu; Phonological Inventory, Alexis L. Campos, Ixchel Mireles, Bryon Haynes, David Kamal, Zachariah Gonzalez

Team - Mere Wudu - Documents

Display of the Consonants and Vowels used to create our language.

Theshrahk Thwath Poem, Mary Arnolds, Sofia Farias, Alexandra Renteria, Nicholas Denmark

Team - Theshrahk Thwath - Documents

This is an original poem written in Theshalshe’s romanized form and orthography and translated into English. The personification of a plant reflects the Theshrahk Thwath society’s close identification to nature.

Theshrahk Thwath Syntax & Grammar, Mary Arnolds, Sofia Farias, Alexandra Renteria, Nicholas Denmark

Team - Theshrahk Thwath - Documents

This document contains different sentence structures that can occur in Theshalshe, highlighting the subject-verb-object pattern. There are examples of plurals, different tenses, conjunctions, adjectives and adverbs. There are also syntactic tree diagrams.

Theshrahk Thwath Semantics And Pragmatics, Mary Arnolds, Sofia Farias, Alexandra Renteria, Nicholas Denmark

Team - Theshrahk Thwath - Documents

This document contains some semantic fields and pragmatic conventions of the Theshalshe language, including apologies, story openings, and conversational turn-taking.

Theshrahk Thwath Swadesh List, Mary Arnolds, Sofia Farias, Alexandra Renteria, Nicholas Denmark

Team - Theshrahk Thwath - Documents

This document contains some the lexicon, verb conjugation patters, plural structures, and nominalization pattern of Theshalshe. The lexicon entries are presented in Theshalshe, romanized form, and a pronunciation guide using the IPA.

Muzibogun Pragmatics, Serena Parra, Maurissio Gonzalez, Renee Alonzo, Cj Spears

Team - Muzibogun - Documents

This shows how and when certain language elements and politeness strategies are used.

A Quarter Century Of Scholarship: Trends In The St Mary’S Law Scholar’S Journal, Trenton Boudreaux

Capstone Projects

This project catalogs the trends of the articles published in The Scholar: St Mary’s Law Review on Race and Social Justice. Over its 25-year history, The Scholar has published 26 volumes discussing issues related specifically to minority and social justice issues. The project catalogs the topics covered in the volumes, and explores this data for historical trends. The project posts these results on the St. Mary’s Law School History page and provides historical context for some of the topics covered. This information provides a valuable resource for researchers into The Scholar as a publication.