Digital Commons Network^™

Exploiting Structures In Reinforcement Learning: Multi-Agent Homogeneity, Euclidean Symmetry, And Natural Languages, Dingyang Chen

Theses and Dissertations

Reinforcement learning (RL) has emerged as a powerful paradigm for decision-making in complex environments. However, many RL tasks exhibit inherent structural properties—such as homogeneity, symmetry, and linguistic patterns—that are often underutilized, leading to inefficiencies in learning and generalization. This dissertation systematically exploits these structures to improve the efficiency, scalability, and robustness of RL algorithms across multi-agent and sequential decision-making settings. First, we investigate homogeneity in multi-agent systems, where agents share similar roles and objectives. By leveraging this structure, we develop communication-efficient actor-critic methods for homogeneous Markov games, enabling scalable learning with reduced coordination overhead. Second, we introduce Euclidean symmetry in …

Comparing And Contrasting Diversity And Inclusion Concepts: An Identity-Blind And Identity-Conscious Application, William Ward

Theses and Dissertations

This dissertation systematically investigates the differences between diversity and inclusion concepts. Notably, this dissertation focuses on exploring the differences between diversity and inclusion climates and recruitment messages. This paper first explores the theoretical traditions that are often applied to diversity (social identity theory) and inclusion climate (optimal distinctiveness theory) and offers guidance on why individuals may react to diversity and inclusion climates differently from the basis of these theoretical foundations. Additionally, this dissertation expands existing theory by promoting a more novel approach of differentiating diversity and inclusion through exploring their relationships with identity-blind and identity-conscious human resource practices. The first …

Supercritical Water Oxidation For Removing Pfas Contaminants: A Numerical Study, Ashley Joy Poyner

Theses and Dissertations

Per – and polyfluoroalkyl substances (PFAS) are a group of stable pollutants known for their long lifetimes and resistance to treatment methods used traditionally to remove other contaminants. PFAS and their ability to accumulate in both aquatic and terrestrial environments present threats such as detrimental effects to people and ecosystems due to their ability to penetrate entire systems. Though many methods are being explored to treat PFAS contamination in different systems, Supercritical Water Oxidation (SCWO) is a promising method for both removing and decomposing PFAS, with the ability to completely oxidize these persistent contaminants. This study is a numerical investigation …

Designing A Genetics-Based Bibliotherapy Model For Children With Inborn Errors Of Metabolism, Kaitlyn Abagail Gmitro

Theses and Dissertations

Bibliotherapy is a psychotherapy technique utilized to teach individuals about concepts through the use of literature and the arts. The primary aim of this research was to examine how a bibliotherapy model could be applied to improve diet and treatment adherence for people affected with Inborn Errors of Metabolism. Prior to this research, no paper has proposed a tailored bibliotherapy approach for genetic conditions. Through analysis of the caregiver-child relationship and disclosure process and the perceived support needs of both caregivers and providers caring for children with IEMS, our goal was to propose a bibliotherapy model to improve adherence and …

Experimental And Numerical Analysis Of Fluidization Of Pelletized Activated Carbon Columns: Effects Of Glass Bead Retention Layer, Amin Nemati Tamar

Theses and Dissertations

In pressure swing adsorption (PSA) processes there is always a desire to process as much gas as possible in the smallest beds possible. This necessarily leads to velocities that, especially during pressure-changing steps, may exceed the adsorbent particle fluidization velocity within the bed. To prevent the possibility of bed expansion and fluidization bed retention systems are usually employed at the top of the bed in the form of dense beads, bags of the same or springs, otherwise the mechanical integrity of the adsorbent might become compromised. PSA process simulation, based on Archimedes’ force balance involving weight, buoyancy and the drag …

The Effects Of Acute Nutrient Intake On Raw Segmental Bioelectrical Impedance Values And Fluid Shifts In Premenopausal Women, Callie Unrein

Theses and Dissertations

Background: Raw bioimpedance measures—impedance (Z), resistance (R), reactance (Xc), and phase angle (PhA)—are emerging tools to assess hydration, cellular integrity, and muscle quality. While multifrequency bioimpedance analysis (MF-BIA) can detect acute physiological shifts, its sensitivity to nutrient intake, especially across hormonal phases in women, remains underexplored. Purpose: This study investigated how essential amino acids (EAA), carbohydrates (CHO), and water (CON) influence postprandial segmental bioimpedance and fluid distribution in healthy women, and whether these responses vary by menstrual hormone phase. Methods: Twenty-two recreationally active women (18–40 years) underwent serial MF-BIA (InBody 970) assessments during high- and low-hormone phases, randomized to one …

Estimating Proximity To Failure Using Repetitions In Reserve In Adults Treated For Cancer, Kylah Elizabeth Jackson

Theses and Dissertations

BACKGROUND: There is a consensus from governing bodies that more evidence is needed in understanding how to properly prescribe, monitor and progress resistance training (RT) in oncology populations. Repetitions in reserve (RIR) has been demonstrated as a quick/easy tool to monitor proximity to failure and interventions using RIR have shown promise in improving muscle strength and mass in older adults and apparently healthy populations. However, the validity of RIR in RT in oncology has yet to be examined. Therefore, the purpose of this study was to assess the accuracy of RIR predications in individuals treated for cancer in a pragmatic …

The Impact Of Small-Scale Conflicts On Post-Soviet Alliances, Ani Hakobyan

Journal of Strategic Security

Military alliances are crucial for international and regional security. However, conflicts may disrupt these connections, weakening alliance structures, particularly in complex regions such as the post-Soviet space. This article examines the effects of small-scale conflicts on the post-Soviet alliance network by analyzing the impact of three conflicts: the 2008 Russo-Georgian War, Russia's 2014 annexation of Crimea, and the 2020 Nagorno-Karabakh (Artsakh) War. Using the temporal exponential random graph model (TERGM), the study finds that three conflicts significantly weakened alliance structures in the region, reducing the likelihood of new alliance ties within both the Collective Security Treaty Organization (CSTO) and broader …

Rethinking Cyber Deterrence: Adapting To The Realities Of The Digital Battlefield, Peter Pijpers, Kraesten Arnold

Journal of Strategic Security

The question of whether deterrence is achievable in or through cyberspace has sparked considerable debate among academics. Over time, arguments have evolved, further entrenching this discourse and moving it out of the mainstream spotlight. This article examines how recent armed conflicts in Ukraine and Gaza may reinvigorate discussions surrounding this issue. It emphasizes that cyber activities can indeed produce deterrent effects while also recognizing the necessity for a new terminology to accurately capture these effects. In cyberspace, traditional deterrent logics—such as deterrence by denial or punishment—along with core principles including credibility, communication, and cost-benefit analysis, do not uniformly apply due …

American Extremism: An Evolutionary Process, Christopher Young, Michael Damian Tucker

Journal of Strategic Security

This article critically examines the historical definitions of American right-wing extremism as utilized by the media, political community, academia, and the government. We suggest that the historical definitions of the right wing are inadequate and fail to describe extremism accurately and consistently. Using evolutionary game theory, this article further argues that right-wing extremism (and left wing) is based on an evolutionary process to secure social existence and will rise as predators challenge historical hierarchical systems.

Latin America’S Policing And Reform In The Age Of Crime Fear, José De Arimatéia Da Cruz Phd, Mph

Journal of Strategic Security

No abstract provided.

Subversion: The Strategic Weaponization Of Narratives. By Andreas Krieg. Washington, D.C.: Georgetown University Press, 2023., Chad M. Briggs Phd

Journal of Strategic Security

No abstract provided.

The Pharmaceutical Applications Of Poisonous Compounds Found In Datura Stramonium, Ruby M. Raffaldt

Senior Theses

Datura stramonium is a plant that is known for its toxicity. However, a facet of this plant’s noxious chemicals, namely its tropane alkaloids, can be used medicinally. The aim of this paper was to compile knowledge on the botanical, chemical, and medicinal properties of Datura stramonium L with a focus on atropine, scopolamine, and anisodamine; three tropane alkaloid compounds with the ability to be both a poison and a medicine. Information was compiled using pre-existing studies, articles, and literature reviews on D. stramonium. For each of the three alkaloids, their biosynthetic pathways, targets, administration, distribution, metabolism, and excretion were discussed. …

The Benefits Of Blood Flow Restriction Training Combined With Low-Load Resistance Training In Arthritis Treatment: A Scoping Review, Maya L. Butcher, Dr. Christine Pellegrini, Kailyn Horn

Senior Theses

Background: Arthritis is a condition affecting millions worldwide, with osteoarthritis (OA) and rheumatoid arthritis (RA) being the most common forms. Resistance training is a widely accepted intervention to strengthen muscles and support joint function, however, high-load resistance training may exacerbate joint pain. Blood Flow Restriction (BFR) training, which involves applying controlled vascular occlusion during low-intensity resistance exercises, has gained attention as a potential alternative to promote muscle growth and strength with minimal joint stress. Objective: This scoping review aims to explore the benefits of BFR techniques in conjunction with low-intensity resistance training for the treatment of arthritis. Methods …

From Pregnancy To Postpartum: A Longitudinal Analysis Of Maternal Depressive Symptoms And Hemoglobin Concentration In Uttar Pradesh, India, Abdullah Nurus Salam Khan

Theses and Dissertations

Background: Perinatal depression and maternal anemia impact maternal health, pregnancy outcomes, and infant growth in low- and middle-income countries. This study examines the prevalence and risk factors of these conditions during pregnancy and postpartum in rural Uttar Pradesh, India. Methods: A prospective cohort study was conducted among 475 pregnant women recruited during early pregnancy (≤20 weeks gestation) and followed through late pregnancy (≥27 weeks) and postpartum (< 42 days of childbirth). The outcome variables were, i) depressive symptoms, assessed using the Edinburgh Postnatal Depression Scale (EPDS), and ii) hemoglobin concentrations, measured using HemoCue Hb 301 analyzer from capillary blood. Multivariable linear regression examined associations of the outcome variables with sociodemographic, obstetric, nutritional, interpersonal, and perinatal factors. Path analysis evaluated direct and indirect paths influencing postpartum hemoglobin. Results: Prevalence of probable depression (EPDS score≥13) peaked in early pregnancy (24%) and declined in late pregnancy (17%) and postpartum (4%). Mean hemoglobin declined from early (10.5 g/dL) to late pregnancy (9.7 g/dL), and partially recovering in postpartum (10.4 g/dL). Household food insecurity was associated with higher depressive symptoms during pregnancy and postpartum (early pregnancy:β=2.61, p=0.011; late pregnancy:β=2.84, p< 0.001; postpartum:β=1.40, p=0.023). Psychological intimate partner violence was associated with greater depressive symptoms in early pregnancy (β=3.19, p=0.001). Receiving more antenatal visits was associated with decrease in depressive symptoms in late pregnancy (β=-0.46, p=0.001) and hemoglobin at postpartum (β=-0.11, p=0.070). Consumption of more food groups was associated with increase in depressive symptoms (β=0.63, p=0.004) and hemoglobin in late pregnancy (β=0.10, p=0.026). Iron folic acid (IFA) consumption was associated with increase in hemoglobin in late pregnancy (β=0.01, p< 0.001) and postpartum (β=0.004, p=0.031). Experiencing postpartum health complications was associated with increase in depressive symptoms (β=0.41, p=0.013) and decrease in hemoglobin concentrations (β=-0.18, p=0.036). Antenatal hemoglobin concentrations mediated the associations of IFA supplementation and dietary diversity with postpartum concentrations. Conclusion: Perinatal depression was associated with socioeconomic vulnerabilities, food insecurity, and intimate partner violence, while hemoglobin concentrations were associated with maternal nutrition and perinatal care. Integrating mental health services and comprehensive nutrition interventions into antenatal and postpartum care can improve psychological and physical well-being of mothers during and after pregnancy.

Augmenting Deep Learning For Efficient Nextg Wireless Communication And Sensing Systems, Hem Kanta Regmi

Theses and Dissertations

Wireless networks have become an integral aspect of our daily lives. Over the years, earlier generations of wireless networks have enabled some innovative applications, such as wireless gaming, fast internet browsing, and home automation, which were previously unattainable. However, to support emerging technologies like autonomous driving, virtual reality, telemedicine, and intelligent manufacturing, which require high data throughput and low latency, there is a need for advanced wireless networks. Legacy networks like WiFi/LTE, which operate below 6 GHz, have limited bandwidth and are insufficient to fulfill the high data throughput demands of several applications. Millimeter-wave (mmWave) networks, operating between 30 GHz …

Approaches To Teaching Music Reading To Students With Dyslexia: A Guide For Piano Teachers, Olivia Grace Bradstreet Colomaio

Theses and Dissertations

Dyslexia is the most common learning disability in the United States, affecting approximately one in five individuals. According to the DSM-V-TR, the ICD-11, and the International Dyslexia Association, dyslexia is a Specific Learning Disorder that causes issues with phonological processing, sequencing of information and information processing, word recognition, reading fluency, and other issues. Due to its prevalence, the chances of piano teachers encountering a student with dyslexia in their teaching studios is highly likely. However, there is relatively little research available for piano teachers of students with dyslexia. In the music lesson, common areas of struggle for students with dyslexia …

Newborn Screening For X-Linked Adrenoleukodystrophy: Experiences, Perspectives, And Future Directions For Genetic Counseling, Sophia Salvatore

Theses and Dissertations

There is a notable lack of research regarding genetic counseling practices for infants with screen-positive results for X-linked adrenoleukodystrophy (X-ALD) via newborn screening (NBS). The exploratory study aimed to understand the experiences of genetic counselors providing follow-up care for these infants, assess the complexities associated with NBS for X-ALD, identify potential gaps in genetic counseling practices, and describe the subsequent impact on patient care. A mixed-methods approach was utilized, incorporating an initial survey and optional semi-structured interviews with practicing genetic counselors who had seen a minimum of five cases of infants with screen-positive results for X-ALD in the last two …

The Role Of B Cells In Promoting Lipid Absorption By Promoting Lacteal Development, Kenny Johnson

Theses and Dissertations

The absorption of dietary lipids in the gut is necessary to maintain the metabolic tone of tissues. Inflammation in the gut can cause defects in lipid absorption, which can result in tissue wasting, otherwise known as cachexia. Cachexia is commonly observed in patients with inflammatory bowel disease and cancer patients. The underlying cause of cachexia is unknown, and there are currently no effective therapeutic options available to treat it. Lymphatic drainage in the small intestine (SI) is specialized to promote the transport of dietary lipids into circulation. Lacteals are blunt-ended lymphatic vessels localized to the central axes of villi in …

Addressing Gaps In Access: Examining Language Barrier Accommodations In Medicaid Member Handbooks, 2015-2019, Sanskruti Patel

Senior Theses

Objective: This study examines the linguistic accessibility of Medicaid Managed Care Organization (MCO) handbooks from 2015 to 2019 by analyzing the instructions provided to access interpreter and written translation services. Trends were compared over time, considering state and plan-level factors that impact equitable healthcare access for Limited English Proficiency (LEP) enrollees.

Methods: A systematic search using manual efforts and FOIA requests located all publicly available Medicaid handbooks from 2015-2019 (N=657) across 39 states with comprehensive MCO plans. These handbooks were coded by independent reviewers to assess the study outcome variables. Random mixed-effects logistic and linear regression models were conducted to …

Impacts On College-Aged Asian American Mental Health, Zahra Soherwardy

Senior Theses

This study explores the relationship between different forms of racial harassment and mental health issues in Asian American college students. Asian American mental health is a growing concern in the field of public health. Asian Americans have the lowest treatment rates and some of the highest stigma levels of any demographic. They are also impacted by the model minority myth and discrimination, further alienating them from getting help. The topics of subtle racism, blatant racism, and current racial discrimination were compared to depressive symptoms, anxiety, self-esteem, and four domains of aggression using survey data. Subtle racism was found to be …

The Roles Of Literature And Film In Shaping Culture: An Examination Of All Quiet On The Western Front And The German Lesson, Charles Hansen

Senior Theses

This paper examines the cultural impacts of All Quiet on the Western Front (Im Westen nichts Neues) and The German Lesson (Deutschstunde). More specifically, it examines the impacts of the works through the shaping of German identity and public memory following World War I and World War II, as well as any long-term impacts that have lasted into the present day. These two works of literature, as well as their respective film adaptations, can serve as vehicles for national reflection, education, and confrontation of the past. This paper will examine the key themes of All Quiet …

Nicotinic Acetylcholine Receptor Expression In Merkel Cell Carcinoma Is Associated With Clinical And Histopathologic Parameters, Christopher R Cunningham, Yiannis P Dimopoulos, Ian M García-Quiñones, Denái R Milton, Manuel Delgado-Vélez, Woo Cheal Cho, Victor G Prieto, José A Lasalde-Dominicci, Leomar Y Ballester, Phyu P Aung

Faculty, Staff and Student Publications

Background: Merkel cell carcinoma (MCC) is a rare, aggressive cutaneous malignancy with neuroendocrine differentiation. Several molecular pathways have been implicated in MCC development and multiple cell-of-origin candidates have been proposed, including neural crest cells, which express acetylcholine receptors (AChRs). The role of nicotinic acetylcholine receptors (nAChRs) in MCC has not been explored. In this study, we investigated if MCC expresses nAChRs and if nAChR expression correlates with patient characteristics.

Methods: The study included 71 MCC cases diagnosed with sufficient tissue available to perform immunohistochemical analysis. The median follow-up was 29.8 months (range, 2.7-234.1). We performed immunohistochemistry using antibodies against the …

Nicotinic Acetylcholine Receptor Expression In Merkel Cell Carcinoma Is Associated With Clinical And Histopathologic Parameters, Christopher R Cunningham, Yiannis P Dimopoulos, Ian M García-Quiñones, Denái R Milton, Manuel Delgado-Vélez, Woo Cheal Cho, Victor G Prieto, José A Lasalde-Dominicci, Leomar Y Ballester, Phyu P Aung

Faculty, Staff and Student Publications

Background: Merkel cell carcinoma (MCC) is a rare, aggressive cutaneous malignancy with neuroendocrine differentiation. Several molecular pathways have been implicated in MCC development and multiple cell-of-origin candidates have been proposed, including neural crest cells, which express acetylcholine receptors (AChRs). The role of nicotinic acetylcholine receptors (nAChRs) in MCC has not been explored. In this study, we investigated if MCC expresses nAChRs and if nAChR expression correlates with patient characteristics.

Methods: The study included 71 MCC cases diagnosed with sufficient tissue available to perform immunohistochemical analysis. The median follow-up was 29.8 months (range, 2.7-234.1). We performed immunohistochemistry using antibodies against the …

Adoptively Transferred Tumor-Specific Il-9-Producing Cytotoxic Cd8+ T Cells Activate Host Cd4+ T Cells To Control Tumors With Antigen Loss, Liuling Xiao, Rui Duan, Wendao Liu, Chuanchao Zhang, Xingzhe Ma, Miao Xian, Qiang Wang, Qi Guo, Wei Xiong, Pan Su, Lingqun Ye, Yabo Li, Ling Zhong, Jianfei Qian, Yong Lu, Zhongming Zhao, Qing Yi

Faculty, Staff and Student Publications

Host effector CD4+ T cells emerge as critical mediators for tumor regression but whether they can be activated by adoptively transferred CD8+ T cells remains unknown. We previously reported that adoptive transfer of interleukin 9 (IL-9)-producing cytotoxic CD8+ T (Tc9) cells achieved long-term control of tumor growth. Here, we demonstrate that murine tumor-specific Tc9 cells control the outgrowth of antigen-loss relapsed tumors by recruiting and activating host effector CD4+ T cells. Tc9 cells secreted IL-24 and recruited CCR7-expressing conventional type 2 dendritic cells (cDC2 cells) into tumor-draining lymph nodes to prime host CD4+ T cells against relapsed tumors. Host CD4+ …

Symptom Documentation In Unstructured Palliative Care Notes Of Children And Adolescents With Cancer., Katherine Bernier Carney, Jacob Wilkes, Tumilara Aderibigbe, Kristin Stegenga, Holly Spraker-Perlman, Lauri A. Linder

Manuscripts, Articles, Book Chapters and Other Papers

CONTEXT: Children and adolescents with cancer experiencing complex symptoms can benefit from subspeciality palliative care. However, standardized methods of symptom documentation by pediatric palliative care teams are lacking. Understanding current approaches to symptom documentation will inform next steps to optimize symptom support.

OBJECTIVE: To explore the documentation of symptom prevalence and characteristics in unstructured clinical notes by pediatric palliative care clinicians caring for children and adolescents with cancer.

METHODS: We reviewed unstructured clinical notes documented by the pediatric palliative care team for 115 children and adolescents with cancer. Symptom-related data were abstracted and evaluated using content analysis based on the …

The Cgas-Sting1 Pathway As A Mediator Of Innate Immune Response In Cardiovascular Disease, Leila Rouhi, Priyatansh Gurha, Ali J Marian

Faculty, Staff and Student Publications

The innate immune response, a rapid and cell-autonomous response of the cell to the pathogens, recognizes the external as well as the internal pathogens, such as self-DNA, released from the damaged cells. The response activates a set of molecules that induce the expression of proinflammatory cytokines and chemokines and leads to inflammation, fibrosis, and cell death. The innate immune response comprised of DNA-sensing protein cyclic guanosine monophosphate-adenosine monophosphate synthase (CGAS) and its downstream molecules, the stimulator of interferon genes 1 (STING1), TANK-binding kinase 1 (TBK1), interferon regulatory factor 3 (IRF3), and nuclear factor kappa B (NFκB), are activated in several …

Role Of Peripheral Amyloid-Β Aggregates In Alzheimer's Disease: Mechanistic, Diagnostic, And Therapeutic Implications, Nazaret Gamez, Rodrigo Morales

Faculty, Staff and Student Publications

No abstract provided.

In Vivo Antibody Labeling Route And Fluorophore Dictate Labeling Efficiency, Sensitivity, And Longevity, Natalie B Hagan, Charles Inaku, Nikesh Kunder, Tayleur White, Thierry Iraguha, Anna Meyer, Kristen E Pauken, Jason M Schenkel

Faculty, Staff and Student Publications

Leukocytes migrate through the blood and extravasate into organs to surveil the host for infection or cancer. Recently, we demonstrated that intravenous (IV) anti-CD45.2 antibody labeling allowed for precise tracking of leukocyte migration. However, the narrow labeling window can make this approach challenging for tracking rare migration events. Here, we show that altering antibody administration route and fluorophore can significantly extend the antibody active labeling time. We found that while both IV and intraperitoneal (IP) anti-CD45.2 antibody labeled circulating leukocytes after injection, they had different kinetic properties that impacted labeling time and intensity. Quantification of circulating antibody revealed that while …

Unleashing The Power Of Multiomics: Unraveling The Molecular Landscape Of Peripheral Neuropathy, Julie Choi, Zitian Tang, Wendy Dong, Jenna Ulibarri, Elvisa Mehinovic, Simone Thomas, Ahmet Höke, Sheng Chih Jin

Faculty, Staff and Student Publications

Peripheral neuropathies (PNs) affect over 20 million individuals in the United States, manifesting as a wide range of sensory, motor, and autonomic nerve symptoms. While various conditions such as diabetes, metabolic disorders, trauma, autoimmune disease, and chemotherapy-induced neurotoxicity have been linked to PN, approximately one-third of PN cases remain idiopathic, underscoring a critical gap in our understanding of these disorders. Over the years, considerable efforts have focused on unraveling the complex molecular pathways underlying PN to advance diagnosis and treatment. Traditional methods such as linkage analysis, fluorescence in situ hybridization, polymerase chain reaction, and Sanger sequencing identified initial genetic variants …