Digital Commons Network^™

Improved Outcomes Of Acute Lymphoblastic Leukemia After Allogeneic Blood Or Marrow Transplantation With High-Dose Post-Transplantation Cyclophosphamide In The Era Of More Effective Pre-Transplant Therapy, Jonathan A Webster, Madison Reed, Hua-Ling Tsai, Philip H Imus, Douglas B Smith, Alexander J Ambinder, Mark J Levis, Amy E Dezern, Gabrielle T Prince, Tania Jain, Javier Bolaños-Meade, Lukasz P Gondek, Gabriel Ghiaur, William Brian Dalton, Theodoros Karantanos, Suman Paul, Ephraim J Fuchs, Cole Sterling, Lode J Swinnen, Nina Wagner-Johnston, Richard F Ambinder, Christian B Gocke, Syed Abbas Ali, Carol Ann Huff, Leo Luznik, Ravi Varadhan, Richard J Jones, Ivana Gojo

Faculty, Staff and Students Publications

The therapeutic landscape in ALL has changed dramatically over the last decade. Allogeneic blood or marrow transplantation (AlloBMT) has also evolved and remains an important option for consolidation. We assessed the interplay between these factors by analyzing the outcomes of 251 adult ALL (214 B and 37 T ALL) patients undergoing alloBMT with post-transplantation cyclophosphamide (PTCy) across two eras: 2008-2014 (ERA1) and 2015-2022 (ERA2). ERA1 patients were younger (median age 45.5 vs. 50, p=0.03), less likely to have an HCT-CI ≥4 (9% vs. 21%, p=0.01), more likely to have MRD by flow cytometry (20% vs. 9%, p=0.01) and receive myeloablative …

Development Of A Risk Score To Aid With The Diagnosis Of Infections After Spinal Cord Injury: Protocol For A Retrospective Cohort Study, Felicia Skelton, Larissa Grigoryan, Joann Pan, Ashley Collazo, Barbara Trautner

Faculty, Staff and Students Publications

Background: Patients with spinal cord injury (SCI) who develop urinary tract infection (UTI) present differently than the non-SCI population. UTIs can cause loss of quality of life and even lead to life-threatening complications including urosepsis. Challenges in SCI management include distinguishing symptomatic UTI from asymptomatic bacteriuria (ASB), which occurs often in patients with SCI, and the lack of standardization in UTI diagnosis in SCI.

Objective: This study aims to set the foundation for the development of a risk score to improve diagnostic accuracy of UTI after SCI.

Methods: This study will use data from the Veterans Health Administration Corporate Data …

"Significant Bodily Intrusions": Investigations Into Law Enforcement Phlebotomy, Anne Kathleen Johnson

Dissertations and Theses

This three-paper dissertation explores law enforcement phlebotomy, the ability of law enforcement officers to draw blood. Phlebotomy is both a ubiquitous, invasive diagnostic tool as well as a social site with complex relational dynamics at play between phlebotomist and patient. Through law enforcement phlebotomy, the blood draw is co-opted from the medical field into the policing field, and the normative framework through which it is used changes: whereas medical edicts instruct providers to work with patients through an ethics of care--respecting consent and refusal--policing is not similarly bound, instead operating through a prioritization of security and efficiency. In the articles …

Magma Evolution And Eruptive History Of Three Fingered Jack: A Mafic Composite Volcano In The Central High Cascades Of Oregon, Javaria Aziz

Dissertations and Theses

The central High Cascades graben in Oregon has been a center for mafic volcanism since its initiation. Three Fingered Jack is one of the larger mafic composite cones in the graben, located 20km south of Mount Jefferson. Three Fingered Jack erupted between 142.1 - 150.8ka, based on Ar⁴⁰/Ar³⁹ age dates. This study provides stratigraphic, compositional and petrographic evidence to understand the eruptive history of Three Fingered Jack and the processes involved in generating compositionally diverse basaltic andesites here.

The basaltic andesites of Three Fingered Jack show three compositional trends of magma evolution: 1) enrichment, 2) depletion and …

Sirt6 Deficiency Promotes Senescence And Age-Associated Intervertebral Disc Degeneration In Mice, Pranay Ramteke, Bahiyah Watson, Mallory Toci, Victoria Tran, Shira N Johnston, Maria Tsingas, Ruteja Barve, Ramkrishna Mitra, Richard Loeser, John Collins, Makarand Risbud

Department of Orthopaedic Surgery Faculty Papers

Intervertebral disc degeneration is a major risk factor contributing to chronic low back and neck pain. While the etiological factors for disc degeneration vary, age is still one of the most important risk factors. Recent studies have shown the promising role of SIRT6 in mammalian aging and skeletal tissue health, however its role in the intervertebral disc health remains unexplored. We investigated the contribution of SIRT6 to disc health by studying the age-dependent spinal phenotype of mice with conditional deletion of Sirt6 in the disc (Acan^CreERT2; Sirt6^fl/fl). Histological studies showed a degenerative phenotype in knockout mice …

Increased Fatty Acid Delivery By Tumor Endothelium Promotes Metastatic Outgrowth, Deanna N Edwards, Shan Wang, Kelby Kane, Wenqiang Song, Laura C Kim, Verra M Ngwa, Yoonha Hwang, Kevin Ess, Mark R Boothby, Jin Chen

Faculty, Staff and Students Publications

Metastatic outgrowth in distant microscopic niches requires sufficient nutrients, including fatty acids (FAs), to support tumor growth and to generate an immunosuppressive tumor microenvironment (TME). However, despite the important role of FAs in metastasis, the regulation of FA supply in metastatic niches has not been defined. In this report, we show that tumor endothelium actively promotes outgrowth and restricts antitumor cytolysis by transferring FAs into developing metastatic tumors. We describe a process of transendothelial FA delivery via endosomes that requires mTORC1 activity. Thus, endothelial cell-specific targeted deletion of Raptor (RptorECKO), a unique component of the mTORC1 complex, significantly reduced metastatic …

Telegroup Parent Behavior Management Training For Disruptive Behavior: Mixed-Methods Comparison Of Effectiveness And Engagement For White And Bipoc Caregivers, Li Shen Chong, Nicole B. Groves, Erin S. Gonzalez

Faculty Research, Scholarly, and Creative Activity

Background: Parent Behavior Management Training (PBMT) is the first-line psychosocial intervention for child disruptive behavior, though research documents disparities in PBMT engagement and effectiveness between Black, Indigenous, and People of Color (BIPOC) and White families. Objective: This study aimed to quantitatively compare clinical outcomes and satisfaction ratings of telegroup PBMT and qualitatively identify themes related to engagement and challenges among White and BIPOC caregivers. Method: Data from 177 caregivers (78% White; 22% BIPOC) of children aged 5 to 12 referred for treatment of disruptive behavior and/or ADHD were collected as part of measurement-based care (MBC) before and after participation in …

Recent Trends In Medical Education To Sustain An Effective Practice - A Systematic Review, Sharon Pricilla Jeevan Kumar Leela Ms., Amtuz Zehra Dr, Ayesha Siddiqhha Mukthar Ms

International Journal of Health and Allied Sciences

Learning processes in medical practices in medicinal schools put more emphasis on the hard sciences than they do on developing soft skills like empathy and communication. For this reason, the medical humanities emerged to provide a "different" take on the creative process. Medical ethics, the doctor-patient relationship, clinical research, mental illness, and professionalism are just a few of the topics that have been utilized to discuss in medical school. A strong connection between classroom learning and clinical experience is crucial for medical school graduates. Students graduating from a medical program are expected to have experience with patient care, clinical procedures, …

Awareness Of Symptoms And Risk Factors Of Ovarian Cancer Among Healthy Women Aged 18 Years And Above: A Narrative Review, Surabhi Sai P Raghavendra, Mackwin Kenwood Dmello, Neevan Dsouza

International Journal of Health and Allied Sciences

Introduction: Ovarian cancer is often termed a "silent killer" due to its late presentation and poor prognosis. Awareness of its symptoms and risk factors is crucial for early healthcare intervention, which can significantly increase survival rates. This review article focuses on awareness of ovarian cancer, the risk factors, symptoms and factors influencing awareness among women.

Methods: Articles published in English between 2009 and 2024 were included, focusing on awareness of ovarian cancer symptoms and risk factors among healthy women aged 18 years and above in a community-based or facility-based study setting.

Results: Overall, awareness of ovarian cancer symptoms …

Beaulieu V. Beaulieu: An Obituary For Lex Loci And An Approach To Interest Analysis, David C. Shonka

Maine Law Review

Clifford Beaulieu, a guest in his father's automobile, was injured when the vehicle struck a telephone pole in Massachusetts. Both parties were residents of Maine. The trip had originated in Maine and was to terminate there. The son filed an action against his father in the Maine Superior Court, alleging negligent operation of the vehicle. On an agreed statement of facts, the case was reported to the Maine Supreme Judicial Court where the defendant argued for dismissal of the action on the grounds that the doctrine of lex loci delictus, the law of the place of the tort, was applicable …

Conservation, Policy And The Role Of Counsel, David J. Halperin

Maine Law Review

The conservation interests in the State of Maine have been roused to a furor by the decision of Maine's highest court in State v. Johnson. The case, in substance, holds that Maine's Wetlands Act is unconstitutional when applied to prohibit the filling of a specific segment of salt water marsh. While both the decision and the underlying statute are of considerable substantive interest, the case deserves particular study for the light it sheds on the role of counsel in helping the legal process accommodate new policy concerns. A note of caution must, of course, be sounded before seeking to generalize …

De Novo Juries, Misdemeanor Counsel, And Other Problems: Changes Ahead For The Maine District Courts?, Pierce B. Hasler

Maine Law Review

The Maine judicial system has two levels of criminal courts, the superior court having exclusive trial jurisdiction over felony prosecutions and the district court operating with concurrent trial jurisdiction for misdemeanors. The district court also processes the preliminary phases of felony cases; included in this function are bail hearings, initial appearances (arraignments), and preliminary hearings. To provide jury trials in misdemeanor prosecutions state law permits all district court convictions to be appealed to the superior court for trial de novo to a jury. The accepted reason for unlimited de novo trials is that the state constitution requires a jury in …

The Constitutional Law Of Remedies In Welfare Litigation, Donald F. Fontaine

Maine Law Review

It is becoming increasingly obvious that the problems of poor people in the United States are dependent, more than those of other classes, upon the proper administration of government agencies. The contact of poor people with government agencies involves most of their chief concerns in life: Welfare, social security, adequate health care, adequate income from work, a safe and healthy place to live, whether privately or publicly owned, and schools that provide real education without racial or economic discrimination. Where payments are improperly withheld from a presumably destitute recipient, the need for a speedy and adequate remedy should be obvious. …

The Development Of Admiralty Jurisdiction And Practice Since 1800, David P. Dawson

Maine Law Review

This book undertakes several tasks. It contains a detailed narrative of the ebb and flow of the admiralty jurisdiction exercised by the English Admiralty Courts from earliest times to the present, together with a look at the practice during each period. Unlike our Admiralty jurisdiction which rests on the Constitution and has grown steadily through court interpretation, the jurisdiction of the English Admiralty Court has expanded and contracted with frequent and varying statutory changes.

Judicial Administration: The American Experience, Robert B. Williamson

Maine Law Review

Professor Karlen's Judicial Administration: The American Experience "contains, in revised and updated form, the substance of three lectures delivered in England in December, 1968, upon the occasion of the founding of the English Institute of Judicial Administration at the University of Birmingham."

The Impact Of General Anesthesia On Postoperative Respiratory Complications In Patients With Chronic Obstructive Pulmonary Disease (Copd): A Literature Review, Oscar Acosta, Lisandra Chinea, Amaan Ismail, Zain Ismail, Matthew Shelnutt

Research Day

Chronic obstructive pulmonary disease (COPD) is a prevalent respiratory disease characterized by airway narrowing and alveoli breakdown that eventually causes air trapping leading to increased Total Lung Capacity (TLC) and compromised expiration. COPD includes chronic bronchitis and emphysema, which are common among smokers. Patients with COPD are at increased risk of perioperative complications, including but not limited to: Increased post-operative pulmonary complications (PPCs), increased risk of respiratory infections, respiratory failure, prolonged ventilator dependence, and subsequent increased length of hospital stay. Understanding the relationship between COPD severity and postoperative outcomes is critical for optimizing perioperative management and reducing morbidity and mortality …

Use Of Simulation For Teaching Biomedical Sciences To Undergraduate Medical Students- A Scoping Review, Joshua Owolabi, Katresa Gardner, Rasheed Agboola, Rekha Yesudas, Jennifer H. Shaw

Research Day

Objective: The objective of this scoping review is to understand the extent and type of evidence in relation to the use of simulation or SIM-based medical education pedagogies to teach biomedical sciences to undergraduate medical students in accredited medical schools, globally. The review considers literature published between 2014-2024.

Introduction: Simulation, which could be generally described as a computer-based or structured model and practice that replicates the processes, behavior, or characteristics of a real-world system or phenomenon, especially for the purpose of education or training, is increasingly becoming popular and relevant in medical education. However, discrete publications with relatively diverse experiences …

Navigating Ethical Frontiers: Frameworks For Responsible Ai Implementation In Healthcare, Emeka Ikeakanam, Onyekachi Adigwe, Joshua Owolabi

Research Day

Objective: The objective of this systematic review is to explore ethical frameworks that have been proposed or implemented to guide the development and deployment of artificial intelligence (AI) in healthcare. With AI becoming increasingly integrated into society, this review aims to identify key ethical principles, governance structures, and regulatory considerations in the evolving landscape of AI-driven medical interventions.

Introduction: Due to the rapid development and expansion of AI, its adoption has arguably exceeded the rate at which proper oversight can take place. In healthcare, the potential of AI to benefit patients as well as physicians and hospital systems prompts discussions …

Addressing The Effects Of Stress On Menstrual Cycle Regularity And Symptoms: A Review Of Contributing Factors, Racial Disparities, And Lifestyle Interventions, Nahimie Louissaint, Saron Araya, Embre Martin, Jennifer Mitchell

Research Day

Introduction: Menstrual health is a critical aspect of overall well-being, yet many individuals experience cycle irregularities influenced by psychological and physiological stressors. Research suggests that both acute and chronic stressors can impact hormonal regulation, leading to menstrual disturbances. Despite growing evidence of this relationship, gaps remain in understanding the underlying mechanisms and effective interventions.

Objective: This literature review aims to examine the relationship between stress and menstrual irregularities by analyzing physiological mechanisms, psychological and lifestyle influences, and potential mitigation strategies.

Methods: A systematic review of peer-reviewed articles, clinical studies, and meta-analyses published in the past two decades was conducted using …

Contributors, Diamond Line Editors

Diamond Line Undergraduate Literary Magazine

No abstract provided.

Acknowledgements, Diamond Line Editors

Diamond Line Undergraduate Literary Magazine

No abstract provided.

Diamond Line - Spring 2025, Diamond Line Editors

Diamond Line Undergraduate Literary Magazine

No abstract provided.

Leading Schools In The Midst Of Covid-19: Experiences Of Basic School Leaders Of The Komenda Edina Eguafo Abrem District Of The Central Region Of Ghana, Corinne Brion

Journal of African Policy Studies

This qualitative study uses a phenomenological approach to understand the experiences of thirteen Ghanaian head-teachers in suburban and rural areas of the Komenda Edina Eguafo Abrem district during the COVID-19 pandemic. Our findings revealed that these leaders faced numerous challenges related to pivoting to remote learning for the first time combined with the lack of access to technology. Other challenges pertained to the absence of infrastructure and resources such as books. Despite these challenges, these Ghanaian head-teachers were able to adapt to the crisis and alter their leadership style to educate the children they served. Currently, there is a limited …

Cover, Table Of Contents, And Editor's Message, Julius A. Amin

Journal of African Policy Studies

No abstract provided.

Social Support, Motivation, And Maternal Knowledge About Providing Essential Health Care Services For Preterm And Low Birth Weight Babies In West Sumatra Province, Indonesia, Ricvan Dana Nindrea, Long Chiau Ming, Nissa Prima Sari

Journal of Health Research

Background: Low birth weight (LBW) and preterm infants face heightened health risks, requiring specialized care. Social support, maternal motivation, and knowledge are vital for their care, yet research on these factors in West Sumatra, Indonesia, is limited. This study examines how social support and maternal motivation enhance maternal knowledge in caring for LBW and preterm infants.

Methods: This community-based, cross-sectional study was conducted from August to October 2024 in Padang City and Solok Regency, West Sumatra. A total of 125 mothers with LBW or preterm infants born between January and December 2023 were selected using multistage random sampling. Data were …

The Development And Impact Of Hospitals Accreditation In Southeast Asia: A Scoping Review, Putri Citra Cinta Asyura Nasution, Dumilah Ayuningtyas, Adang Bachtiar, Besral Besral

Journal of Health Research

Background: The Association of Southeast Asian Nations (ASEAN) Economic Community facilitates its members to provide accessible health services and to improve their quality and safety. Hospital accreditation (HA) is a tool to improve quality, safety, and access. This study aimed to examine publications on HA in ASEAN countries, as well as analyze their implementation and impact on this region.

Methods: This study used Arksey and O'Malley's framework scoping review. Articles were from ProQuest, Scopus, PubMed, MEDLINE, Wiley Online Library, ScienceDirect, SAGE journals, and JSTOR databases. Full-text articles written in English from 2000 to 2024 were searched using the …

Comparison Of Age-Standardized Suicide Rate And Standard Population Composition In South Korea, 2005–2022, Chae-Bong Kim, Eun-Kyu Shine

Journal of Health Research

Background: South Korea has the highest suicide rate among the countries of the Organization for Economic Cooperation and Development, with the highest rates found among older adults and adolescents. Calculating accurate suicide rates requires sophisticated estimates that consider population composition. This study aimed to report the age-standardized suicide rates of South Koreans between 2005 and 2022.

Method: We calculated the age-standardized suicide rates in South Korea utilizing cause-of-death statistics data from the years 2000, 2010, 2015, 2018 and 2022 and the standard populations from 2000 and 2020. We reported the differences in suicide rates in South Koreans by age group …

Preliminary Questions Of Fact: Respective Roles Of Judge And Jury In Maine Courts, Maine Law Review

Maine Law Review

Virtually indisputable in the law is the notion that the trial judge determines questions of admissibility of evidence. However, when admissibility depends upon the evaluation of a preliminary question of fact, both courts and commentators disagree as to whether the judge should continue to occupy the role of sole decision-maker. The intertwining of fact, the preliminary condition, and law, the admissibility decision, raises some havoc with accepted views of the judge as arbiter of the law and the jury as fact finder. If the judge determines both questions, he is resolving not only legal, but also factual issues traditionally within …

Comparative Negligence And Comparative Contribution In Maine: The Need For Guidelines, Maine Law Review

Maine Law Review

In the recent case of Packard v. Whitten, Maine became the second state to adopt the doctrine of comparative contribution among joint tortfeasors. The decision stressed the point that comparative contribution was merely a logical outgrowth of Maine's Comparative Negligence Statute and that, in particular, the 1969 amendment to that law "would appear to have little purpose except to lay the basis for a comparative contribution." The court concluded that the implementation of this new doctrine would pose no major problems: "More than five years' experience in apportioning causal fault under our Comparative Negligence Law convinces us that this change …

Arbitration As An Alternative To Judicial Settlement: Some Selected Perspectives, Mashall E. Lippman

Maine Law Review

The increasing interest in arbitration as a means of judicial reform has been largely due to the fact that arbitration provides a forum for dispute settlement apart from the traditional judicial system. In other words, arbitration is regarded as a useful reform measure primarily because it affords potential litigants a forum other than the already over-burdened courts. Little consideration has been given to the possibility that in some areas arbitration may in fact be both a better forum and a better method of resolving disputes than the traditional judicial system. This article will discuss three areas, areas which are susceptible …