Digital Commons Network^™

Umn Morris Announces 2025 Student Award Winners, Communications And Marketing

Campus News Archive

No abstract provided.

The Ai-Powered Future Of Digital Transformation: Enhancing Organizations And Leadership Development, Martin Sposato, Eduardo Carlos Dittmar

All Works

Purpose: This paper examines the integration of AI-enhanced coaching systems into traditional organizational development practices and develops a comprehensive theoretical framework to understand these complex interactions. Design/methodology/approach: A narrative literature review synthesizes theoretical perspectives and empirical studies at the intersection of digital transformation and coaching practices. This review systematically examines multiple theoretical frameworks related to human–technology collaboration in organizational contexts. Findings: The research establishes a theoretical framework comprising four interconnected domains: cognitive amplification, collaborative learning, ethical governance and adaptive evolution. Three hypothetical case studies demonstrate the practical application of this framework across diverse organizational settings, revealing both challenges and opportunities …

Exploring Differences Between Mothers’ And Fathers’ Language Attitudes In Multilingual London, Anna Caunt, Caroline Floccia, Rana Abu-Zhaya

School of Psychology

This study investigated the language attitudes of parents raising multilingual infants in London. Using a newly developed questionnaire, 131 mothers and fathers rated their attitudes towards their languages across three themes: (1) their emotional resonance with the language, (2) the significance of the language in their personal life, and (3) its importance in bringing up a multilingual child. Parents varied in the combination of languages they reported speaking, and English, the society language, was either parents’ L1, L2 or L3. Our results showed that both mothers and fathers had similarly positive attitudes towards English, but differed in their attitudes towards …

Poetries Of Abandonment: A Study Of Plath And Glück, Yara Abdelmoneim

Theses and Dissertations

This thesis explores the intersection between literature and trauma, which can be discerned in the key works of two poets, Sylvia Plath and Louise Glück. While offering readings of crucial poems, the thesis also examines the interrelations among trauma, memory and narrative as theorized by two contemporary psychiatrists, Bessel van der Kolk and Judith Herman. Both Plath and Glück wrote about personal and generational trauma after going through different experiences of abandonment. Absence, indirection and repetition provide the basis for literary techniques that allow their traumas to be better understood by authors and readers alike. The degree to which each …

Cmlit 101w Syllabus, Alexander Moudrov

Open Educational Resources

The syllabus for CMLIT 101W (Global Literatures 1) based on open-source materials.

Corradjust Unveils Biologically Relevant Transcriptomic Correlations By Efficiently Eliminating Hidden Confounders, Stepan Nersisyan, Phillipe Loher, Isidore Rigoutsos

Computational Medicine Center Faculty Papers

Correcting for confounding variables is often overlooked when computing RNA-RNA correlations, even though it can profoundly affect results. We introduce CorrAdjust, a method for identifying and correcting such hidden confounders. CorrAdjust selects a subset of principal components to residualize from expression data by maximizing the enrichment of "reference pairs" among highly correlated RNA-RNA pairs. Unlike traditional machine learning metrics, this novel enrichment-based metric is specifically designed to evaluate correlation data and provides valuable RNA-level interpretability. CorrAdjust outperforms current state-of-the-art methods when evaluated on 25 063 human RNA-seq datasets from The Cancer Genome Atlas, the Genotype-Tissue Expression project, and the Geuvadis …

Post-Recovery Viral Shedding Shapes Wastewater-Based Epidemiological Inferences, Tin Phan, Samantha Brozak, Bruce Pell, Stanca M Ciupe, Ruian Ke, Ruy M Ribeiro, Anna Gitter, Kristina D Mena, Alan S Perelson, Yang Kuang, Fuqing Wu

Faculty, Staff and Student Publications

Background: The prolonged viral shedding from the gastrointestinal tract is well documented for numerous pathogens, including SARS-CoV-2. However, the impact of prolonged viral shedding on epidemiological inferences using wastewater data is not yet fully understood.

Methods: To gain a better understanding of this phenomenon at the population level, we extended a wastewater-based modeling framework that integrates viral shedding dynamics, viral load data in wastewater, case report data, and an epidemic model.

Results: Our results indicate that as an outbreak progresses, the viral load from recovered individuals gradually becomes predominant, surpassing that from the infectious population. This phenomenon leads to a …

New York City Misses The Exit To Traffic Safety, Joseph Caffrey

Capstones

New York City Misses the Exit to Traffic Safety investigates New York City’s mounting traffic violence crisis through the lens of a devastating crash that killed a Brooklyn mother and her two daughters. It examines the city’s inconsistent enforcement of reckless driving and the failure of the Dangerous Vehicle Abatement Program (DVAP), which aimed to reform recidivist speeders. The piece investigates the imperfections of Vision Zero, public backlash to automated enforcement, and the broader failure to prevent recidivist speeding. It also explores policy alternatives like Intelligent Speed Assistance (ISA), highlighting legislative efforts to revive accountability and save lives, while advocating …

Increasing The Educational Attainment Of Youth In Extension Of Foster Care Through Positive Youth Development Centered Programming, Julia M. Rossmiller

Senior Capstone Papers

Approximately 20,000 young adults age out of the foster care system in America each year. Of these 20,000 individuals, less than one-quarter will choose to participate in Extension of Foster Care services. Even fewer will complete a bachelor’s degree by age 26. Extension of Foster Care provides financial support for housing and education for young adults pursuing an education or working. However, most young adults have received little or no education on post-secondary options despite having the financial resources available for these programs. Low levels of protective factors further raise the barrier to entry for young adults to pursue an …

Decoding Resistance To Immune Checkpoint Inhibitors In Non-Small Cell Lung Cancer: A Comprehensive Analysis Of Plasma Proteomics And Therapeutic Implications, Michal Harel, Nili Dahan, Coren Lahav, Eyal Jacob, Yehonatan Elon, Igor Puzanov, Ronan J. Kelly, Yuval Shaked, Raya Leibowitz, David P. Carbone, David R. Gandara, Adam P. Dicker

Department of Radiation Oncology Faculty Papers

BACKGROUND: Immune checkpoint inhibitors (ICIs) have shown substantial benefit for patients with advanced non-small cell lung cancer (NSCLC). However, resistance to ICIs remains a major clinical challenge. Here, we perform a comprehensive bioinformatic analysis of plasma proteomic profiles to explore the underlying biology of treatment resistance in NSCLC.

METHODS: The analysis was performed on 388 "resistance-associated proteins" (RAPs) that were previously described as pretreatment plasma proteomic predictors within the PROphet computational model designed to predict ICI clinical benefit in NSCLC. Putative tissue origins of the RAPs were explored using publicly available datasets. Enrichment analyses were performed to investigate RAP-related biological …

Workplace Mobbing, Job Satisfaction, And Intent To Leave The Information Technology Industry, Sherry Elaine Baker-Thompson

Walden Dissertations and Doctoral Studies

Some information technology leaders are increasingly concerned about employees’ intent to leave their organizations, as it contributes to higher turnover rates, increased recruitment costs, and potential disruptions to project continuity and service delivery. Grounded in affective events theory, the purpose of this quantitative correlational study was to examine the relationship between workplace mobbing, job satisfaction, and the intent to leave the information technology industry. The study surveyed 101 information technology employees residing in the United States who had experienced workplace mobbing. The participants completed the Negative Acts Questionnaire, the Job Satisfaction Questionnaire, and the Turnover Intention Questionnaire. Results from a …

Essays On The Social Operations, Chenshan Hu

Olin Business School Graduate Student Theses and Dissertations

This dissertation focuses on the intersection of operational decisions and their social implications, an area of growing importance as businesses increasingly optimize for efficiency while simultaneously facing pressures to consider environmental sustainability and technological adoption. In my research, I utilize field experiment and econometrics to study how innovations in delivery speed and algorithmic implementation influence human behavior and create broader impacts beyond immediate business outcomes. In Chapter 1, "Green E-commerce: Environmental Impact of Fast Delivery'', we study the impact of faster delivery on how consumers place orders (their order frequency and basket sizes) and the subsequent environmental implications. Specifically, we …

Essays In Empirical Asset Pricing, Jiaen Li

Olin Business School Graduate Student Theses and Dissertations

My dissertation explores two broad questions. First, what is the role of intangible forces like ideological narratives in belief formation and asset prices? Second, how can we understand the systematic components in asset pricing? In Chapter 1, using cryptocurrencies as a laboratory, I examine the role of ideological narratives in asset prices—an area remains underexplored. Leveraging social media data and large language models to measure ideology dynamics, I find that fluctuations in two ideological narratives—anarchism and decentralization—are priced in the cross-section of cryptocurrency returns. Consistent with the view that factors proxy for state variables, ideology factors contain distinct information about …

Leveraging Ai For Marketing Decisions: Algorithmic Targeting And Healthcare Applications, Annie Shi

Olin Business School Graduate Student Theses and Dissertations

In this dissertation, I leverage artificial intelligence (AI) for making effective marketing decisions, specifically on how to measure the causal effects of targeting promotions and detecting suspicious retail buyers of opioids. In the first chapter, we propose a novel approach in measuring the true causal effects of targeting promotions. Targeting promotions on online platforms are often determined by AI algorithms, which utilize extensive customer and seller information to generate various algorithmic scores for targeting. Effective targeting, however, will lead to selection bias when evaluating the causal effects of promotions. we analyzed 2,294 promotion experiments on a major online retail platform …

Essays In Supply Behavior In Sharing Economy, Chong Bo Wang

Olin Business School Graduate Student Theses and Dissertations

My dissertation investigates supply behavior within the sharing economy, focusing specifically on the ride-sharing market. Leveraging quantitative methods such as structural modeling, field experiments, and lab experiments, I examine supplier behaviors to help platforms design more effective incentives—including subsidies and strategically framed rewards—to better match supply with demand. In Chapter 1, “Using Field Experiments to Infer Cross-Side Network Effects in the Ride-Sharing Market: How Does Driver Supply Impact Rider Orders, Cancellations, and Customer Lifetime Value?”, I address the central question of how shifts in driver supply affect rider behavior. Collaborating with a leading ride-sharing platform, I implement a natural field …

Innovative Algorithmic Approaches In Revenue Management, Yukai Huang

Olin Business School Graduate Student Theses and Dissertations

In this dissertation, I design and analyze tractable algorithms for sequential decision-making problems under uncertainty, with various applications in revenue management. More specifically, I focus on innovative business strategies that have emerged in recent years, with applications ranging from reusable product sales, opaque selling, and maritime shipping. For each application, I identify the unique operational requirements, highlight the complexity of the underlying decision problems, and develop tractable solution approaches. I also provide both theoretical analysis and numerical evaluation to evaluate the performance of the proposed policies. In the first chapter, I study the joint inventory and online assortment problem, wherein …

Behavioral Decision-Making In Platform Operations, Nicholas Clyde

Olin Business School Graduate Student Theses and Dissertations

Over the past decade, online platforms have experienced significant growth, both in terms of user interest and the range of services they offer. These platforms now provide a wide array of services, from groceries (e.g., Instacart) and transportation (e.g., Uber, Lyft) to entertainment (e.g., TikTok, Twitch). Understanding how individuals interact with these platforms is crucial, not only for the platforms’ success but also for assessing their broader societal impact. In my research, I employ a range of empirical methods—including field experiments, natural experiments, and online experiments—to explore how online platforms can intentionally and unintentionally influence behaviors." In Chapter 1, “The …

Essays In Corporate Governance And Financial Intermediation, Renping Li

Olin Business School Graduate Student Theses and Dissertations

Antitrust regulations in banking have historically targeted commercial banking activities. In the first chapter, I ask does the consolidation of investment banks have competitive effects? Using the geographically fragmented municipal bond underwriting market as a natural laboratory and employing a stacked difference-in-differences specification, I find that the underwriting spread increases by 4.8% of its sample mean following within-market consolidation. The effects double for larger M&As or in more concentrated markets and do not dissipate over time. These M&As do not generate efficiency gains that manifest as lower bond yields or substitution of other issuer-paid services. The findings remain robust when …

A Review Of Medical Ethics In Orthopaedic Surgery: Current Foci And Future Considerations, Ryan X Lam, Zhi Mei Sonia He, Ruhi Thapar, Maggie Wang, Dion G Birhiray, Matthew Milad, Lara Ouellette, Umar Ghilzai, Tucker J Cushing, M Brent Price, Brenden B Ronna, Omar H Atassi, Christopher H Perkins, John R Dawson, William M Granberry, Melvyn A Harrington, Douglas R Dirschl, Lorenzo R Deveza

Library Staff Publications

Medical ethics education is a required component of orthopaedic surgery resident training per the Accreditation Council for Graduate Medical Education (ACGME) guidelines, although no standardized curriculum currently exists.

Beyond the 4 principles of bioethics (autonomy, beneficence, nonmaleficence, justice), additional ethical concepts relevant to orthopaedic care include utilitarianism, deontology, virtue ethics, moral intuitionism, microethics, and narrative ethics.

Ethical themes identified in the literature relevant to orthopaedic surgery include the ethics involved in medical decision-making, use of new technologies, caring for vulnerable patients, performing high-stakes procedures, the impacts of trainee status on patient care, and patient attitude regarding conflict of interest.

Ethical …

The Impact Of Benefits Cliffs And Asset Limits On Low-Wage Workers: New Evidence From A Nationally Representative Survey, Stephen Roll, Selina Miller, Mathieu Despard

Center for Social Development Research

Over 40 million workers in the United States receive public benefits. Many face a challenge: They would like to earn higher wages, take on more hours, or accept better jobs, but doing so can push them over benefit-program limits, causing them to lose eligibility or experience reductions in the benefits they need to make ends meet. This is also an issue for employers, whose ability to attract and retain talent is affected when the workforce’s employment decisions are driven by concerns about public benefit eligibility. Drawing on data from the Workforce Economic Inclusion and Mobility (WEIM) survey administered to a …

M6a Modification Is Incorporated Into Bacterial Mrna Without Specific Functional Benefit, Klara Szydlo, Leonardo Santos, Thomas W. Christian, Sunita Maharjan, Amir Dorsey, Isao Masuda, Jingxuan Jia, Yuan Wu, Weixin Tang, Ya-Ming Hou, Zoya Ignatova

Department of Biochemistry and Molecular Biology Faculty Papers

N 6-Methyladenosine (m6A), the most abundant modification in eukaryotic messenger RNAs (mRNAs), has also been found at a low level in bacterial mRNAs. However, enzyme(s) that introduce m6A modification on mRNAs in bacteria remain elusive. In this work, we combine deep-sequencing approaches that identify m6A sites with in vitro biochemical studies to identify putative m6A methyltransferases that would modify Escherichia coli mRNAs. We tested four uncharacterized candidates predicted to encode proteins with putative methyltransferase domains, whose deletion decreased the m6A level. However, in vitro analysis with the purified putative methyltransferases revealed that none of them installs m6A on mRNA. Exposure …

Multicomponent Parenteral Lipid Emulsions Do Not Prevent Liver Injury In Neonatal Pigs With Obstructive Cholestasis, Greg Guthrie, Caitlin Vonderohe, Valeria Meléndez Hebib, Barbara Stoll, Douglas Burrin

Children’s Nutrition Research Center Staff Publications

Biliary atresia (BA) is a pediatric liver disease that often necessitates parenteral nutrition (PN) to support growth due to impaired liver function. While soy-based lipid emulsions (SLE) are commonly used in PN, they may contribute to cholestatic liver injury. In contrast, mixed lipid emulsions (MLE) show promise in preventing cholestasis in infants without BA, potentially by restoring bile flow. However, their effectiveness in patients of complete bile duct obstruction, as seen in BA, remains uncertain. To explore the potential benefits of MLE in BA, we utilized a neonatal pig model of bile duct ligation (BDL). Pigs underwent either BDL or …

Comprehensive Evaluation Of Phosphoproteomic-Based Kinase Activity Inference, Sophia Müller-Dott, Eric J Jaehnig, Khoi Pham Munchic, Wen Jiang, Tomer M Yaron-Barir, Sara R Savage, Martin Garrido-Rodriguez, Jared L Johnson, Alessandro Lussana, Evangelia Petsalaki, Jonathan T Lei, Aurelien Dugourd, Karsten Krug, Lewis C Cantley, D R Mani, Bing Zhang, Julio Saez-Rodriguez

Faculty, Staff and Students Publications

Kinases regulate cellular processes and are essential for understanding cellular function and disease. To investigate the regulatory state of a kinase, numerous methods have been developed to infer kinase activities from phosphoproteomics data using kinase-substrate libraries. However, few phosphorylation sites can be attributed to an upstream kinase in these libraries, limiting the scope of kinase activity inference. Moreover, inferred activities vary across methods, necessitating evaluation for accurate interpretation. Here, we present benchmarKIN, an R package enabling comprehensive evaluation of kinase activity inference methods. Alongside classical perturbation experiments, benchmarKIN introduces a tumor-based benchmarking approach utilizing multi-omics data to identify highly active …

Untargeted Proteomics Enables Ultra-Rapid Variant Prioritisation In Mitochondrial And Other Rare Diseases, Daniella H Hock, Nikeisha J Caruana, Liana N Semcesen, Nicole J Lake, Luke E Formosa, Sumudu S C Amarasekera, Tegan Stait, Simone Tregoning, Leah E Frajman, Adam M Bournazos, David R L Robinson, Megan Ball, Boris Reljic, Bryony Ryder, Mathew J Wallis, Anand Vasudevan, Cara Beck, Heidi Peters, Joy Lee, Natalie B Tan, Mary-Louise Freckmann, Mitomdt Diagnostic Network For Genomics And Omics, Vasiliki Karlaftis, Chantal Attard, Paul Monagle, Amanda Samarasinghe, Rosie Brown, Weimin Bi, Monkol Lek, Robert Mcfarland, Robert W Taylor, Michael T Ryan, Sandra T Cooper, Zornitza Stark, John Christodoulou, Alison G Compton, David R Thorburn, David A Stroud

Faculty, Staff and Students Publications

Background: Only half of individuals with suspected rare diseases receive a genetic diagnosis following genomic testing. A genetic diagnosis allows access to appropriate care, restores reproductive confidence and reduces the number of potentially unnecessary interventions. A major barrier is the lack of disease agnostic functional tests suitable for implementation in routine diagnostics that can provide evidence supporting pathogenicity of novel variants, especially those refractory to RNA sequencing.

Methods: Focusing on mitochondrial disease, we describe an untargeted mass-spectrometry based proteomics pipeline that can quantify proteins encoded by > 50% of Mendelian disease genes and > 80% of known mitochondrial disease genes in clinically …

Spousal Bereavement Enhances Proinflammatory Cytokine Production To Acute, Psychological Stress., E Lydia Wu-Chung, Ryan L. Brown, Robert Suchting, Jensine Paoletti-Hatcher, Michelle A. Chen, Angie S. Leroy, Kyle W. Murdock, Cobi J. Heijnen, Christopher P. Fagundes

Psychology Faculty Publications and Presentations

Early widowhood is characterized by chronic stress and is associated with a higher risk of incident depression and cardiovascular-related morbidity and mortality. Peripheral inflammation is involved in the pathogenesis of major depressive disorder and atherothrombosis and may represent a common mechanism underlying widow(er)'s elevated risk for both health conditions. Chronic psychological stress sensitizes the release of proinflammatory cytokines during the peripheral stress response. The present study examined whether recent spousal bereavement enhances the inflammatory response to an acute, psychological stressor. Recently widowed older adults (n = 143) and non-widowed controls (n = 69) participated in a quasi-experimental study, during which …

The Joint Association Of Diet Quality And Sleep Regularity With Incident Cardiovascular Disease In The Multi-Ethnic Study Of Atherosclerosis, Kaitlin S Potts, Claire Veldkamp, Alexis C Wood, Erin D Michos, Raymond Noordam, Tianyi Huang, Susan Redline, Heming Wang

Children’s Nutrition Research Center Staff Publications

Background/objectives: Diet quality and sleep regularity both influence cardiovascular disease (CVD) risk and may influence each other, but there is scarce evidence for their joint or interacting associations in relation to CVD. We assessed these associations in the Multi-Ethnic Study of Atherosclerosis (MESA).

Methods: Participants free of CVD with valid diet and sleep measures in 2010-2013 were included and followed through 2020 for detection of incident CVD (188 events detected over 8.8 years among 1782 participants; 55% women). Sleep timing and duration regularity were assessed via the intra-individual SD of sleep onset time and duration across 5- to 7-day actigraphy. …

The Perk/Atf4 Pathway Is Required For Metabolic Reprogramming And Progressive Lung Fibrosis, Jyotsana Pandey, Jennifer L Larson-Casey, Mallikarjun H Patil, Chao He, Nisarat Pinthong, A Brent Carter

Faculty, Staff and Students Publications

Asbestosis is a prototypical type of fibrosis that is progressive and does not resolve. ER stress is increased in multiple cell types that contribute to fibrosis; however, the mechanism(s) by which ER stress in lung macrophages contributes to fibrosis is poorly understood. Here, we show that ER stress resulted in protein kinase RNA-like ER kinase (PERK; Eif2ak3) activation in humans with asbestosis. Similar results were seen in asbestos-injured mice. Mice harboring a conditional deletion of Eif2ak3 were protected from fibrosis. Lung macrophages from asbestosis individuals had evidence of metabolic reprogramming to fatty acid oxidation (FAO). Eif2ak3fl/fl mice had increased oxygen …

Youth’S Experiences In Trauma-Informed Writing Instruction: A Narrative Inquiry Analysis, Shantell Lee

LSU Doctoral Dissertations

This study examines the experiences of high school age youth who engage trauma-informed writing instruction in an afterschool setting. Trauma-informed writing instruction can aid youth in processing their lived experiences and the after-school program utilizes a curriculum that connects traditional aspects of the writing workshop with trauma-informed writing instruction. Participants in this study included youth who were enrolled in the after-school program and their adult facilitator. For this study, data was collected through observations, semi-structured individual interviews, my research journal, and students’ written pieces. These data sources were then analyzed through the narrative inquiry methodology which resulted in the participants’ …

Retention Intervention Program Success: An Inquiry Into Learning Organization Structural And Cultural Elements In California Community Colleges, Paul Vernon Wickline

Dissertations and Theses

Community colleges serve a diverse, underrepresented, and economically disadvantaged student population, yet most students fail to complete their academic goals, with students from marginalized groups facing even more significant disparities. Some colleges have implemented Early Alert and Intervention (EA&I) programs to improve retention and completion rates. However, colleges may face organizational challenges in implementing and sustaining these retention programs. This qualitative study examined structural and cultural elements in community colleges that have successfully implemented EA&I programs, focusing on student services and student affairs practices that support a learning-centered environment. Findings suggest that effective EA&I programs are grounded in inclusive, collaborative, …

It Is Not Clear How Well Physical Activity Promotion Materials Are Understood: Findings From A Rapid Literature Review, Jafra D. Thomas, Jasmine C. Wong, Regina F. Hockert, Yi Sheng Wu, Winston Kennedy

Topics in Exercise Science and Kinesiology

Topics in Exercise Science and Kinesiology Volume 6: Issue 1, Article 6, 2025. Efforts to promote physical activity and other health-related behaviors are more effective when resource materials are understood by a wide and diverse audience. Before our lab’s previous investigations (Thomas et al., 2024), only one study seemed to use the cloze procedure to directly test the comprehension (i.e., readability) of physical activity promotion material (Cardinal & Seidler, 1995). Thus, this rapid literature review sought to (a) determine the extent the cloze procedure has been used to study physical activity promotion material comprehension in lay adults and (b) collate …