Digital Commons Network^™

Afghanistan: Taliban’S Second Chance And Red Strategy, Oleg Golishnikov

Journal of Strategic Security

An objective evaluation of Afghanistan’s political and socioeconomic situation since the Taliban’s takeover in August 2021 is crucial for understanding and addressing security issues at the national, regional, and global levels. Unlike most studies, this article provides new insights, offering a balanced assessment of the situation in Afghanistan and developing recommendations on dealing with the Taliban regime. By employing qualitative methods and a rational theory framework, this article argues that Afghanistan under Taliban rule is experiencing a mix of positive and negative trends. Major positive trends include the relative peace in Afghanistan, the Taliban’s real power and control over the …

Space Piracy: Preparing For A Criminal Crisis In Orbit. By Marc Feldman And Hugh Taylor. Hoboken, Nj: Wiley, 2025., Mark T. Peters Ii

Journal of Strategic Security

No abstract provided.

Effects Of Verbal Tasks On Driving Simulator Performance, Jonathan Cheshire Rann

Theses and Dissertations

We report the results from a driving simulator paradigm we developed to test the effects of simple verbal tasks on simultaneous driving performance. A total of 74 undergraduate students participated in two experiments in which they controlled a car using the steering wheel to track a moving target. The dependent measure, overall deviation from target, was continuously recorded. Experiment 1 (E1) tested tracking performance during slow and fast target speeds under conditions involving either no verbal input or output (Absent), passive listening to spoken prompts via headphones (Listen), or responding to the spoken prompts (Respond). Experiment 2 (E2) was similar …

Stimulation Of The Rostromedial Tegmental Nucleus Induces Long-Lasting Avoidance Behavior, Jacob Ryan Watson

Theses and Dissertations

The role of midbrain dopamine (DA) activity in reward seeking and reinforcement learning is well-documented, contrasting the lesser-understood impact of inhibitory signaling on DAergic activity, especially in the context of aversive learning and avoidance. The rostromedial tegmental nucleus (RMTg) is a GABAergic midbrain structure activated by aversive stimuli and exerts inhibitory influence over ventral tegmental area (VTA) DAergic activity in response to aversive consequences. Stimulation of the RMTg decreases the firing rate of VTA DA neurons and direct inhibition of the RMTg – VTA circuit enhances persistent reward seeking despite aversive consequences, a major criterion of substance use disorder (SUD). …

The Impact Of The Flipped Learning Approach On Student Engagement In A High School Chemistry Classroom, Alana Lyn Hicks

Theses and Dissertations

This mixed-methods action research study investigated the impact of the flipped classroom approach on student engagement and attitudes within a science classroom. Data was collected using student-reported responses on the Classroom Engagement Inventory, Motivated Strategies for Learning Questionnaire, student journal entries, teacher reflective journals, and an observation tracking chart kept by the classroom teacher. Findings revealed that the flipped classroom model significantly increased affective and cognitive engagement among students in a larger class size, as well as for medium-achieving students and girls. These results suggest that while the flipped classroom has the potential to enhance engagement, its effectiveness is influenced …

Clinical Correlates: Using Case-Based Learning In The Physician Assistant Classroom, Pamela Schindler Wilson

Theses and Dissertations

Physician Assistant (PA) education is rigorous and comprehensive. In only 27 months, the students must learn medical knowledge and skills for effective patient care. Instruction must be efficient and effective to teach these students how to be safe and functional PAs. Of primary concern is teaching students how to perform like clinicians, which requires critical thinking, self-directed learning, and teamwork.

This convergent, mixed-methods action research explored the impacts of case-based learning (CBL) in the PA classroom. The findings support using CBL to develop clinical reasoning skills, improve comprehension of the material, and develop self-directed learning skills. CBL requires the students …

Lessons In Game Use: Examining Engagement And Content Knowledge With The Use Of Digital Game-Based Learning Lessons In Biology, Rebecca Anne Valencia

Theses and Dissertations

According to both national and local data, students in high school biology classes are disengaged in content learning and do not demonstrate sufficient understanding of the content taught during units focused on the mechanisms of heredity and gene expression. Traditional teaching methods do not hold their interest which leads to disengagement and missed learning opportunities. The purpose of this action research was to evaluate the effect of digital game-based learning lessons on biology 1 students’ engagement and content knowledge application regarding the mechanisms of heredity and gene expression, as well as on the students’ perceptions of their digital game-based learning …

Explainable Process Recommendation Through Multi-Contextual Grounding Of Dynamic Multimodal Process Knowledge Graphs, Revathy Venkataramanan

Theses and Dissertations

Can I eat this food or not? Is this food suitable for diabetes and why? Which AI pipeline is best suited for a given task and dataset? How should an end-to-end pipeline be constructed? These questions differ from factual question-answering tasks. Recipes and AI pipelines are processes consisting of several entities interacting with each other. A recipe consists of ingredients, cooking methods, and their interactions, while an AI pipeline includes datasets, preprocessing techniques, models, hyperparameters, tasks, and results. Each entity must be analyzed individually, and collective inferencing is performed to derive the final decision. This decision-making process, known as compositional …

Margery's Visions: Sight, Emulation, And Medieval Wall Paintings In The Book Of Margery Kempe, Kristin L. Harrell

Theses and Dissertations

This project puts the history, context, and reception of medieval murals in dialog with The Book of Margery Kempe to identify neglected parallels between Margery’s sense of sight and the visual culture around her. Guided by a method of recovery that draws on interdisciplinary approaches to text and image, this dissertation combines digital tools, close reading, and archival accounts to compare how Margery responded to visions of holiness—both in spiritual revelations and in physical imagery—in murals which would have been on display during and in proximity to her travels. While mapping, close reading, and analysis have been applied to Margery …

Analyzing Factors Affecting Retention And Attrition Rates Of Teachers In The Pee Dee Region Of South Carolina, Jessica Allen

Theses and Dissertations

The purpose of this qualitative action research study was to determine the factors and variables that affected the retention and attrition rates of novice and seasoned teachers in the Pee Dee region of South Carolina. Utilizing three frameworks, the Self-efficacy theory, the Social Identity theory, and the Multidimensional Theory of Burnout, the researcher conducted a virtual survey of 33 respondents and interviewed seven participants to collect data. Data was thematically coded to discover commonalities amongst the participant responses.

The data revealed administrative influence, teacher working conditions such as autonomy, time, and control, and workload were the most frequent elements of …

Conjuring Realities: Southern Supernaturalism And Race From The Antebellum Era To The Early Twentieth Century, Dylan T. Kobus

Theses and Dissertations

Conjure practices in the nineteenth-century American South, such as “Hoodoo” or “Voodoo,” are commonly portrayed as primarily “black” beliefs or entrenched in “Africanistic” cultures. For the enslaved, their black spiritual systems, including conjure, were a powerful tool of resistance against the white enslaver. Black conjure practitioners established themselves as an affordable and pervasive medical alternative to often ineffective or harmful professional medicines for black and white Southerners, regardless of class. In this way, conjure challenged the authority of racial capitalism and destabilized the perceived moral and intellectual superiority of whiteness. Moreover, by examining legal documents, newspapers, fictional literature, and oral …

Reassessing Readiness: Physical Performance Trajectories And Future Physical Military Readiness, Giovanna Leone

Theses and Dissertations

This dissertation consists of three studies integrating frequentist and machine learning techniques to examine physical fitness trajectories and future physical military readiness. Study 1 consists of a cross-sectional examination of Physical Fitness Test (PFT) scores from four cohorts of first-year Cadets at a Senior Military College from 2019 to 2022. Study 2 consists of a longitudinal examination of PFT performance from one cohort of Cadets across a baseline test and three years of training at a Senior Military College. Study 3 examines predictive machine learning and growth curve modeling methods to project future physical military readiness based on motor competence …

Conceptions Of Epic Heroism In Thomas May’S Continutation, Michael Blake Hoehn

Theses and Dissertations

Thomas May’s A Continuation of the Subiect of Lucan's Historicall Poem till the Death of Iulius Cæser, continues Lucan’s creative vision of critiquing heroism. Despite his attempt at maintaining an indifferent world, May’s Continuation implicitly favors the heroism of the Pompeians.

Both Caesar and the Pompeians base their heroic conceptions on ideals found in Greek and Roman marital and national heroism. Caesar and his enemies believe that his victories in battle result from Fortune’s protection and approval, allowing Caesar to justify the ideals of traditional heroism. However, Fortune in the Continuation acts as an independent force, making these misinterpretations …

The Tur Nout Effect: Challenging The Median Voter Theorem, George Thomas Rogers

Theses and Dissertations

The classical Median Voter Theorem (MVT) predicts that, in a two-party system with majority rule, candidates will converge toward the ideological center to capture the median voter. This logic, grounded in spatial models of political competition, assumes full voter participation and fails to account for the growing ideological polarization in modern democracies. This thesis reevaluates the MVT by incorporating probabilistic turnout into a utility-based model of voter behavior. It theorizes that turnout is shaped not only by ideological proximity but also by expressive motivations, including both strong affinity and strong aversion to candidates. A novel measure of turnout utility is …

Between Florida And The World: Young People And The Politics Of Citizenship, Jessica Flach

Theses and Dissertations

This thesis critically examines how American high school students experience and make sense of global citizenship within the context of a commercial educational tour. Drawing on a case study of students from a Title I public high school in Florida, the research interrogates the narratives of civic transformation promoted by educational travel companies and explores how these narratives intersect with students’ lived realities. Combining ethnographic methods, interviews, and critical discourse analysis, the study reveals that global citizenship is not meaningfully realized through such travel experiences; rather, it is fragmented, depoliticized, and often disconnected from the civic education students receive in …

Addressing Key Challenges In Mhz Power Converters, Aqarib Hussain

Theses and Dissertations

Power electronics are essential in applications such as aerospace, electric vehicles, and electric ships where compact, efficient, and high power-density converters are increasingly demanded. This push toward miniaturization has led to converter designs operating at switching frequencies in the megahertz (MHz) range. Higher-frequency operation enables significant reductions in passive component sizes—particularly transformers and inductors—thereby facilitating dense packaging. However, these benefits come with new challenges, including increased thermal stress, complex semiconductor behavior, higher-frequency magnetic design constraints, and elevated electromagnetic interference (EMI).

This research addresses several key challenges in MHz converter design. The first part involves the development of a 1-MHz, 1-kW …

A Spatial Scan Statistic For Group Testing Data, Vincent Onyame

Theses and Dissertations

Group testing involves pooling specimens from multiple individuals and offers an efficient means to surveil low-prevalence pathogens, but poses challenges for spatial cluster detection when only pooled results are observed. In this thesis, we develop a spatial scan statistic tailored to group-testing data with variable pool sizes. The statistic compares a null hypothesis of a homogeneous infection rate across all clusters to an alternative hypothesis that infection probabilities differ inside and outside a candidate cluster, with both models fitted by maximum likelihood estimation. We approximate the null distribution of the maximum likelihood ratio test via Monte Carlo simulation.

Through a …

Understanding Verbal Irony: A Contrastive Analysis Of Personal And Informational Common Ground, Ruhan Çoban

Theses and Dissertations

This study investigates how representations of personal common ground (PCG; viz., close relationships vs. strangers) and informational common ground (ICG; viz., shared world knowledge) interact in shaping a reader’s comprehension of verbal irony in fictional narratives. While previous research has shown that greater familiarity among story characters enhances readers’ comprehension of ironic statements made by the characters (Gibbs, 2000; Kreuz et al., 1999; Kreuz & Link, 2001; Pexman & Zvaigzne, 2004), the interplay between representations of PCG and ICG remains understudied. In this study, we assumed that ICG takes precedence over PCG. Accordingly, we predicted that irony comprehension would be …

Mtap Immunohistochemistry As A Surrogate Marker Of Cdkn2a Loss In Brain Tumors: A Meta-Analysis And Literature Review, Antonio Dono, Diego Pichardo-Rojas, Leonardo Mendoza Mora, Pavel S Pichardo-Rojas, Luis A Marin-Castañeda, Abril Carrillo, Adrian Coria Medrano, Yoshua Esquenazi, Leomar Y Ballester

Faculty, Staff and Student Publications

Given the known relationship between CDKN2A homozygous deletion (HD) and worsened outcomes in both meningiomas and IDH-mutant astrocytomas, it is paramount to identify CDKN2A HD for accurate risk stratification of patients. Multiple array platforms can detect CDKN2A HD. However, these methods are expensive and are not readily available at every institution. To address this, we conducted a meta-analysis and literature review to evaluate 5'-methylthioadenosine phosphorylase (MTAP) expression determined by immunohistochemistry (IHC) as a surrogate of CDKN2A HD. Our study analyzed 7 cohort studies, 3 of which focused on meningiomas encompassing a total of 87 patients; and 4 studies were conducted …

I2moe: Interpretable Multimodal Interaction-Aware Mixture-Of-Experts, Jiayi Xin, Sukwon Yun, Jie Peng, Inyoung Choi, Jenna L Ballard, Tianlong Chen, Qi Long

Faculty, Staff and Student Publications

Modality fusion is a cornerstone of multimodal learning, enabling information integration from diverse data sources. However, vanilla fusion methods are limited by

It Is Time We Include Leadership Education And Experiences In Mfm Training And Lifelong Learning, Cheryl A Moyer, Timothy R B Johnson

Faculty, Staff and Student Publications

No abstract provided.

Federated Target Trial Emulation Using Distributed Observational Data For Treatment Effect Estimation, Haoyang Li, Chengxi Zang, Zhenxing Xu, Weishen Pan, Suraj Rajendran, Yong Chen, Fei Wang

Faculty, Staff and Student Publications

Target trial emulation (TTE) aims to estimate treatment effects by simulating randomized controlled trials using real-world observational data. Applying TTE across distributed datasets shows great promise in improving generalizability and power but is always infeasible due to privacy and data-sharing constraints. Here we propose a Federated Learning-based TTE framework, FL-TTE, that enables TTE across multiple sites without sharing patient-level data. FL-TTE incorporates federated protocol design, federated inverse probability of treatment weighting, and a federated Cox proportional hazards model to estimate time-to-event outcomes across heterogeneous data. We validated FL-TTE by emulating Sepsis trials using eICU and MIMIC-IV data from 192 hospitals, …

Dynamic Few-Shot Prompting For Clinical Note Section Classification Using Lightweight, Open-Source Large Language Models, Kurt Miller, Steven Bedrick, Qiuhao Lu, Andrew Wen, William Hersh, Kirk Roberts, Hongfang Liu

Faculty, Staff and Student Publications

Objective: Unlocking clinical information embedded in clinical notes has been hindered to a significant degree by domain-specific and context-sensitive language. Identification of note sections and structural document elements has been shown to improve information extraction and dependent downstream clinical natural language processing (NLP) tasks and applications. This study investigates the viability of a dynamic example selection prompting method to section classification using lightweight, open-source large language models (LLMs) as a practical solution for real-world healthcare clinical NLP systems.

Materials and methods: We develop a dynamic few-shot prompting approach to classifying sections where section samples are first embedded using a transformer-based …

Non-Invasive Tools For Analysis Of Plasma Membrane Protein Topology In Living Cells, Daria Savenkova, Leysan Bulatova, Vera Skripova, Ramziya Kiyamova, Mikhail Bogdanov

Faculty, Staff and Student Publications

Membrane protein topology studies offer guidance to membrane protein structure, folding, and function, serving as a credible scaffold for designing site-directed mutagenesis and biochemical experiments, helping to identify functionally significant extracellular and intracellular regions, modeling three-dimensional structures, and building reliable mechanistic models. Membrane protein structure as a function of given lipid composition and physiological state of the cell is best probed in whole intact cells. A described simple and advanced immunofluorescence protocol applied to the transmembrane orientation of extramembrane domains permits a topology analysis of plasma membrane proteins in their native state in living unperturbed eucaryotic cells. The accessibility of …

Long Akap18 Isoforms Anchor Ubiquitin Specific Proteinases And Coordinate Calcium Reuptake At The Sarcoplasmic Reticulum, Taeyeop Park, Katherine Forbush, Yong Li, Oscar Vivas, Kacey J Rosenthal, Jerome Falcone, Cassandra J Wong, James E Bruce, Claudia Moreno, Carmen W Dessauer, John D Scott

Faculty, Staff and Student Publications

Subcellular targeting of signaling enzymes influences where and when various modes of intracellular communication operate. Macromolecular complexes of signal transduction and signal termination elements favor reversible control of repetitive processes. This includes adrenergic stimulation of excitation–contraction coupling in the heart. Long isoforms of A-kinase anchoring protein 18 (AKAP18γ and δ) modulate this process via regulation of calcium uptake into the sarcoplasmic reticulum through the Ca2+ATPase 2a (SERCA2a). AKAP18 proximity-proteomic screening in cardiomyocytes identifies networks for protein kinase A (PKA) and ubiquitin-specific proteinases (USPs). A 2′phosphoesterase domain on AKAP18 interfaces with the USP4 isoform at the Z bands of sarcomeres. PKA …

Bridging Cell Morphological Behaviors And Molecular Dynamics In Multi-Modal Spatial Omics With Morphlink, Jing Huang, Chenyang Yuan, Jiahui Jiang, Jianfeng Chen, Sunil S Badve, Yesim Gokmen-Polar, Rossana L Segura, Xinmiao Yan, Alexander Lazar, Jianjun Gao, Bing Yao, Michael Epstein, Linghua Wang, Jian Hu

Faculty, Staff and Student Publications

Multi-modal spatial omics data are invaluable for exploring complex cellular behaviors in diseases from both morphological and molecular perspectives. Current analytical methods primarily focus on clustering and classification, and do not adequately examine the relationship between cell morphology and molecular dynamics. Here, we present MorphLink, a framework designed to systematically identify disease-related morphological-molecular interplays. MorphLink has been evaluated across a wide array of datasets, showcasing its effectiveness in extracting and linking interpretable morphological features with various molecular measurements in spatial omics analyses. These linkages provide a transparent view of cellular behavior heterogeneity within tissue regions with similar cell type compositions, …

Utility Of The Us Preventive Services Task Force For Preeclampsia Risk Assessment And Aspirin Prophylaxis, Thomas F Mcelrath, Arun Jeyabalan, Arkady Khodursky, Alison B Moe, Manfred Lee, Maneesh Jain, Laura Goetzl, Elizabeth F Sutton, Pamela M Simmons, George R Saade, Antonio Saad, Luis D Pacheco, Esther Park-Hwang, Antonina I Frolova, Ebony B Carter, Ai-Ris Y Collier, Daniel G Kiefer, Vincenzo Berghella, Rupsa C Boelig, Michal A Elovitz, Cynthia Gyamfi-Bannerman, Joseph R Biggio, Kara Rood, William A Grobman, Carrie Haverty, Morten Rasmussen

Faculty, Staff and Student Publications

Importance: The US Preventive Services Task Force (USPSTF) guidelines on preeclampsia risk assessment and aspirin prophylaxis (AP) have not been evaluated for clinical utility.

Objective: To evaluate which characteristics in the USPSTF guidelines identify risk status and the association of preeclampsia risk with AP recommendations.

Design, setting, and participants: This observational cohort study enrolled from July 2020 to March 2023 with data analysis performed from October to December 2024. Enrollment occurred at 11 centers throughout the US or via direct-to-participant recruitment. Pregnant participants aged 18 years or older with a singleton pregnancy less than 22 weeks' gestation were selected via …

Practical Considerations For Using The Tite-Boin Design To Handle Late-Onset Toxicity Or Fast Accrual In Phase I Trials, Kai Chen, Ting-Yu Chen, Yiming Zhang, Ruitao Lin, Ying Yuan

Faculty, Staff and Student Publications

Conducting phase I trials is particularly challenging when dealing with late-onset dose-limiting toxicity (DLT) or when patient accrual is rapid relative to the DLT assessment window. In such cases, a new cohort may be ready for enrollment before the DLT assessments are complete for the current cohort, complicating dose assignment decisions. The time-to-event Bayesian optimal interval (TITE-BOIN) design was developed to address this issue by enabling real-time dose assignment for new cohorts, even when some enrolled patients' DLT data are still pending. This design has been increasingly adopted in practice. Upon reviewing trial protocols utilizing TITE-BOIN, we observed considerable variation …

Myh11 Rare Variant Augments Aortic Growth And Induces Cardiac Hypertrophy And Heart Failure With Pressure Overload, Zhen Zhou, Kgosi Hughes, Nisha Saif, Hyoseon Kim, Michael P Massett, Mingjie Zheng, Alana C Cecchi, Dongchuan Guo, David R Murdock, Ping Pan, Jelita S Clinton, Jun Wang, John M Greally, Dianna M Milewicz

Faculty, Staff and Student Publications

Smooth muscle cell-specific myosin heavy chain, encoded by MYH11, is selectively expressed in smooth muscle cells (SMCs). Pathogenic variants in MYH11 predispose to a number of disorders, including heritable thoracic aortic disease associated with patent ductus arteriosus, visceral myopathy, and megacystis-microcolon-intestinal hypoperistalsis syndrome. Rare variants of uncertain significance occur throughout the gene, including MYH11 p.Glu1892Asp, and we sought to determine if this variant causes thoracic aortic disease in mice. Genomic editing was used to generate Myh11E1892D/E1892D mice. Wild-type (WT) and mutant mice underwent cardiovascular phenotyping with and without transverse aortic constriction (TAC). Myh11E1892D/E1892D and WT mice displayed …

Incomplete Toxicity Reporting And Use Of Toxicity-Minimizing Language In Phase Iii Oncology Trials, Avital M Miller, Adina H Passy, Alexander D Sherry, Ramez Kouzy, Joseph Abi Jaoude, Timothy A Lin, Gabrielle S Kupferman, Esther J Beck, Pavlos Msaouel, Ethan B Ludmir

Faculty, Staff and Student Publications

Purpose: This study aimed to determine complete toxicity reporting (CTR), and the use of subjective toxicity-minimizing language (TML) among phase III oncology trials.

Methods: Two-arm superiority-design phase III oncology trials published from 2002 to 2020 were reviewed for toxicity data. CTR was defined as reporting total adverse events (TAEs), total serious adverse events (SAEs), total deaths, and study therapy discontinuations because of toxicity. Guideline concordance was defined according to guidelines published in the BMJ (defined as reporting total SAEs, total deaths, and study therapy discontinuations because of toxicity). TML was defined as a set of terms that subjectively downplay the …