Digital Commons Network^™

Diffusion Model For Medical Image Denoising, Reconstruction And Translation, Wei Wang, Shuo Li

Faculty Scholarship

Diffusion models, as a class of generative models, have demonstrated significant performance in image generation since their inception. The fundamental principle behind diffusion models is the definition of a forward process and a reverse process. The input data is progressively perturbed by adding random noise during the forward process, and the expected noise distribution is learned. In the reverse process, noise is gradually reduced from a Gaussian distribution to generate the image. Recently, diffusion models have been widely adopted in various image processing tasks, including text-to-image synthesis, denoising, segmentation, and object detection. In medical image analysis, diffusion models have shown …

Utility Of The Us Preventive Services Task Force For Preeclampsia Risk Assessment And Aspirin Prophylaxis, Thomas Mcelrath, Arun Jeyabalan, Arkady Khodursky, Alison Moe, Manfred Lee, Maneesh Jain, Laura Goetzl, Elizabeth Sutton, Pamela Simmons, George Saade, Antonio Saad, Luis Pacheco, Esther Park-Hwang, Antonina Frolova, Ebony Carter, Ai-Ris Collier, Daniel Kiefer, Vincenzo Berghella, Rupsa Boelig, Michal Elovitz, Cynthia Gyamfi-Bannerman, Joseph Biggio, Kara Rood, William Grobman, Carrie Haverty, Morten Rasmussen

Department of Obstetrics and Gynecology Faculty Papers

IMPORTANCE: The US Preventive Services Task Force (USPSTF) guidelines on preeclampsia risk assessment and aspirin prophylaxis (AP) have not been evaluated for clinical utility.

OBJECTIVE: To evaluate which characteristics in the USPSTF guidelines identify risk status and the association of preeclampsia risk with AP recommendations.

DESIGN, SETTING, AND PARTICIPANTS: This observational cohort study enrolled from July 2020 to March 2023 with data analysis performed from October to December 2024. Enrollment occurred at 11 centers throughout the US or via direct-to-participant recruitment. Pregnant participants aged 18 years or older with a singleton pregnancy less than 22 weeks' gestation were selected via …

Allied Health Student's Attitudes And Beliefs On Health Literacy Issues Focused On The Non-Native English-Speaking Community, Amy I. Thompson

Graduate Theses, Dissertations, and Capstones

Today's allied health students and their professors are faced with many challenges, including the low level of health literacy among the United States population. Healthy People 2020 defined health literacy as “the degree to which individuals have the capacity to obtain, process, and understand basic health information and services needed to make appropriate health decisions” (Healthy People 2030). This definition was expanded in Healthy People 2030, to include concepts related to personal and organizational health literacy. Social determinates, such as a language barrier, further complicates an already complex situation with health literacy levels. This focus group, interview-based qualitative …

Using Confidence Scores To Improve Eyes-Free Detection Of Speech Recognition Errors, Sadia Nowrin, Keith Vertanen

Michigan Tech Publications

Conversational systems rely heavily on speech recognition to interpret and respond to user commands and queries. Despite progress on speech recognition accuracy, errors may still sometimes occur and can significantly affect the end-user utility of such systems. While visual feedback can help detect errors, it may not always be practical, especially for people who are blind or low-vision. In this study, we investigate ways to improve error detection by manipulating the audio output of the transcribed text based on the recognizer's confidence level in its result. Our findings show that selectively slowing down the audio when the recognizer exhibited uncertainty …

Perceptions Of Blind Adults On Non-Visual Mobile Text Entry, Dylan Gaines, Keith Vertanen

Michigan Tech Publications

Text input on mobile devices without physical keys can be challenging for people who are blind or low-vision. We interview 12 blind adults about their experiences with current mobile text input to provide insights into what sorts of interface improvements may be the most beneficial. We identify three primary themes that were experiences or opinions shared by participants: the poor accuracy of dictation, difficulty entering text in noisy environments, and difficulty correcting errors in entered text. We also discuss an experimental non-visual text input method with each participant to solicit opinions on the method and probe their willingness to learn …

Tailoring Hiv/Aids Communication To The Cultural Contexts Of The Borana Pastoral Community In Ethiopia, Dano Olana, Sabihah Moola

Journal of Social, Behavioral, and Health Sciences

The HIV/AIDS health communication approach in sub-Saharan Africa has often overlooked sociocultural specificities. The current approach follows a generalist notion that does not consider the specific contextual domains accordingly. Similarly, the cultural appropriateness of HIV/AIDS health communication among the Borana pastoral community in Ethiopia is not clear. In this study, we aimed to explore whether HIV/AIDS communication among the Borana pastoral community was tailored to the cultural contexts of the community. A qualitative case study was used to unpack the cultural communication contexts for HIV/AIDS. We collected data using three methods, namely, in-depth interviews, focus group discussions, and document analysis …

Risk Factors For In-Stent Stenosis After Flow-Diverter Implantation For Intracranial Aneurysm: A Single Center Analysis Of 161 Consecutive Patients, Rabab Alshahrani, Spyridon Karadimas, Mohammed Ali Alvi, Patrick Joseph Nicholson, Timo Krings

Department of Neurosurgery Faculty Papers

INTRODUCTION: Flow diverters (FD) are used for the treatment of intracranial aneurysms, by redirecting flow and serving as a scaffold for endothelial coverage of the aneurysm ostium. However, in-stent stenosis has been observed in some patients treated with these devices, the cause of which and the epidemiology remaining elusive. In the current study we aimed to elucidate potential factors leading to higher degree of in-stent stenosis including gender, location, and type of FD.

METHODS: The authors queried their institutional Electronic Health Record (EHR) for all patients undergoing FD for intracranial saccular aneurysms. We excluded cases where an FD was performed …

Patient-Centered, Theory-Based, Online Intervention To Promote A Physically Active Lifestyle For People With Multiple Sclerosis: Protocol For A Randomized Controlled Trial, Chungyi Chiu, Vaishnavi Sridharan, Mojtaba Khaliji, Md Refat Uz Zaman Sajib, Xiaotian Gao, Kathleen Zackowski

Children’s Nutrition Research Center Staff Publications

Background: People with multiple sclerosis (MS) experience life challenges due to the nature of disease progression. Although an active lifestyle has been shown effective for symptom and relapse management, most people with MS lead a sedentary lifestyle and do not reach the recommended physical activity (PA) guidelines.

Objective: This study aims to test the preliminary efficacy of a codeveloped, online self-management intervention based on the health action process approach (HAPA) adapted for people with MS to cultivate a physically active lifestyle.

Methods: The 8-week intervention program was developed using community-based participatory research based on the HAPA. The program includes increasing …

Engaging Trusted Messengers In Public Health Response: Key Strategies To Building Community Trust Among Cdc’S Prevention Research Center’S Vaccine Confidence Network, Emily Stiehl, Amy Borg, John P Cullen, Anaïs Mendiola, Olivia Dominguez, Danielle Pester, Shan Qiao, Pooja Gandhi, Nicole Kuiper, Princilla Minkah, Shekwonya Samuel, Stephen Flores, Richard Quartarone, Grace W Ryan, Paula Cuccaro, Maria E Fernández, Sage Kim

Faculty, Staff and Student Publications

As part of Centers for Disease Control and Prevention's (CDC) Prevention Research Center (PRC) Vaccine Confidence Network (PRC VCN), 26 academic institutions were funded to increase COVID-19 vaccine confidence and uptake in their communities. Six sites (in communities located in Alabama, Illinois, Massachusetts, New York, South Carolina, and Texas) formed a workgroup to identify emergent themes, and share challenges and opportunities across projects. This essay describes their efforts to engage trusted messengers in vaccine activities, and discusses strategies to develop and sustain these types of partnerships in the future. All sites recruited trusted messengers with strong community relationships to engage …

The First Documented Case Of Melanism In Sciurus Anomalus, Recorded In Türkiye, Burak Akdağ, Balkan Mega

Turkish Journal of Zoology

This study reports the first documented case of melanism in the Caucasian squirrel (Sciurus anomalus) from Türkiye. While melanism has been documented in 12 other species within the Sciurus genus, it has not previously been recorded in S. anomalus. The observation was made during a herpetological field survey in Erzincan Province, Türkiye, where a melanistic specimen was photographed in a mixed habitat comprising natural vegetation and cultivated land. In mammals, melanism is widely regarded as an adaptive trait, potentially conferring advantages such as improved thermoregulation in colder climates and enhanced crypsis in shaded forest environments. This novel observation not only …

The Prevalence And Correlates Of Aberrant Opioid-Related Behaviours Among Patients With Sickle Cell Disease In Oman: A Cross-Sectional Study, Abdullah Al Abulsalam, Khawla Al Kindi, Abdullah Al Ghailani, Hamed Al Sinawi, Naser Al Balushi, Salam Al Kindi, Sathiya P. Murthi, Amal Al Fahdi, Mohammed Al Alawi

Sultan Qaboos University Medical Journal

Objectives: This study aimed to assess the prevalence of aberrant opioid-related behaviours (AORB) among patients with sickle cell disease (SCD) in Oman and identify associated risk factors. Methods: This cross-sectional analytical study was conducted at Sultan Qaboos University Hospital, Muscat, Oman from June to December 2022. Patients with SCD aging 18–65 years old were included and clinically observed for more than 3 months. The Current Opioid Misuse Measure (COMM) was used to evaluate AORB with scores of ≥9 indicating high risk. Demographic and clinical data were collected. The association between AORB and clinical-demographic variables was examined using the Chi-square test. …

Efficacy Of A Novel Bcl-Xl Degrader, Dt2216, In Preclinical Models Of Jak2-Mutated Post-Mpn Aml, Zhe Wang, Anna Skwarska, Gowri Poigaialwar, Sovira Chaudhry, Alba Rodriguez-Meira, Pinpin Sui, Emmanuel Olivier, Yannan Jia, Varun Gupta, Warren Fiskus, Cassandra L Ramage, Guangrong Zheng, Alexandra Schurer, Kira Gritsman, Eirini P Papapetrou, Kapil Bhalla, Daohong Zhou, Adam J Mead, Raajit K Rampal, Jeffrey W Tyner, Hussein A Abbas, Naveen Pemmaraju, Qi Zhang Tatarata, Marina Konopleva

Faculty, Staff and Student Publications

Acute myeloid leukemia (AML) that evolves from myeloproliferative neoplasm (MPN) is known as post-MPN AML. Current treatments do not significantly extend survival beyond 12 months. B-cell lymphoma-extra large (BCL-xL) has been found to be overexpressed in leucocytes from patients with MPN, making it a potential therapeutic target. We investigated the role of BCL-xL in post-MPN AML and tested the efficacy of DT2216, a platelet-sparing BCL-xL proteolysis-targeting chimera, in preclinical models of post-MPN AML. We found that BCL2L1, the gene encoding BCL-xL, is expressed at higher levels in patients with post-MPN AML than in those with de novo AML. Single-cell multiomics …

Cover And Contents

Turkish Journal of Zoology

No abstract provided.

An Acoustofluidic Device For Sample Preparation And Detection Of Small Extracellular Vesicles, Jessica F. Liu, Jianping Xia, Joseph Rich, Shuaiguo Zhao, Kaichun Yang, Brandon Lu, Ying Chen, Tiffany Wen Ye, Tony Jun Huang

Faculty Publications

Small extracellular vesicles (sEVs) have emerged as powerful vectors for liquid biopsy, offering a noninvasive window into the dynamic physiological and pathological states of the body. However, to fully leverage the clinical potential of sEV biomarkers, it is imperative to develop robust and efficient technologies for their isolation and analysis. In this study, we introduce a novel sharp-edge acoustofluidic platform designed for rapid and effective sample preparation, coupled with sensitive detection of specific sEV populations based on their surface markers. Our approach utilizes acoustically activated sharp-edge microstructures to concentrate bead-bound sEVs within the microfluidic device, facilitating immediate visualization by fluorescence …

Identifying The Desired Word Suggestion In Simultaneous Audio, Dylan Gaines, Keith Vertanen

Michigan Tech Publications

We explore a method for presenting word suggestions for non-visual text input using simultaneous voices. We conduct two perceptual studies and investigate the impact of different presentations of voices on a user's ability to detect which voice, if any, spoke their desired word. Our sets of words simulated the word suggestions of a predictive keyboard during real-world text input. We find that when voices are simultaneous, user accuracy decreases significantly with each added word suggestion. However, adding a slight 0.15 s delay between the start of each subsequent word allows two simultaneous words to be presented with no significant decrease …

Electrochemically-Assisted Low Power Density Laser Writing On Stainless Steel Via Enrichment Of Chromium Oxides, Zechariah Pfaffenberger, Lianlian Liu, Tae Kyong John Kim, Vignesh Venkataramani, Lydia Kisley

Faculty Scholarship

Laser color marking produces nearly permanent, environmentally friendly, vibrant colors on surfaces. However, previous work has used high-power-density pulsed lasers to induce the physicochemical reactions for marking. Here, laser color marking on stainless steel 304 (SS304) is performed with a less expensive continuous wave (CW) laser and a power density five orders of magnitude below that previously reported by combining an electrochemical cell with a fluorescence microscope. Using a combination of optical microscopy, x-ray photoelectron spectroscopy, and bulk electrochemistry, it is demonstrated that the laser-induced luminescence and colors are due to enrichment (32 ± 9% increase) of Cr2O3 in the …

Integrative Spatial Omics Reveals Distinct Tumor-Promoting Multicellular Niches And Immunosuppressive Mechanisms In Black American And White American Patients With Tnbc, Qian Zhu, Akhila Balasubramanian, Jaya Ruth Asirvatham, Megha Chatterjee, Badrajee Piyarathna, Jaspreet Kaur, Nada Mohamed, Ling Wu, Stacy Wang, Niloufar Pourfarrokh, Paula Danika Binsol, Mahak Bhargava, Uttam Rasaily, Yitian Xu, Junjun Zheng, Deborah Jebakumar, Arundhati Rao, Carolina Gutierrez, Angela R Omilian, Carl Morrison, Gokul M Das, Christine Ambrosone, Erin H Seeley, Shu-Hsia Chen, Yi Li, Eric Chang, Xiaoxian Li, Elizabeth Baker, Ritu Aneja, Xiang H-F Zhang, Arun Sreekumar

Center on Aging Staff Publications

Racial disparities in the clinical outcomes of triple-negative breast cancer (TNBC) have been well-documented, but the underlying biological mechanisms remain poorly understood. To investigate these disparities, we employed a multi-omic approach integrating imaging mass cytometry and spatial transcriptomics to characterize the tumor microenvironment (TME) in self-identified Black American (BA) and White American (WA) TNBC patients. Our analysis revealed that the TME in BA patients is marked by a network of endothelial cells, macrophages, and mesenchymal-like cells, which correlates with reduced patient survival. In contrast, the WA TNBC microenvironment is enriched in T-cells and neutrophils, indicative of T-cell exhaustion and suppressed …

Publisher Correction: Comprehensive Evaluation Of Phosphoproteomic-Based Kinase Activity Inference, Sophia Müller-Dott, Eric J Jaehnig, Khoi Pham Munchic, Wen Jiang, Tomer M Yaron-Barir, Sara R Savage, Martin Garrido-Rodriguez, Jared L Johnson, Alessandro Lussana, Evangelia Petsalaki, Jonathan T Lei, Aurelien Dugourd, Karsten Krug, Lewis C Cantley, D R Mani, Bing Zhang, Julio Saez-Rodriguez

Faculty, Staff and Students Publications

No abstract provided.

Multi-Ancestry Genome-Wide Meta-Analysis Of 56,241 Individuals Identifies Known And Novel Cross-Population And Ancestry-Specific Associations As Novel Risk Loci For Alzheimer’S Disease, Farid Rajabli, Penelope Benchek, Giuseppe Tosto, Nicholas Kushch, Jin Sha, Katrina Bazemore, Congcong Zhu, Wan-Ping Lee, Jacob Haut, Kara L Hamilton-Nelson, Nicholas R Wheeler, Yi Zhao, John J Farrell, Michelle A Grunin, Yuk Yee Leung, Pavel P Kuksa, Donghe Li, Eder Lucio Da Fonseca, Jesse B Mez, Ellen L Palmer, Jagan Pillai, Richard M Sherva, Yeunjoo E Song, Xiaoling Zhang, Takeshi Ikeuchi, Taha Iqbal, Omkar Pathak, Otto Valladares, Dolly Reyes-Dumeyer, Amanda B Kuzma, Erin Abner, Larry D Adams, Perrie M Adams, Alyssa Aguirre, Marilyn S Albert, Roger L Albin, Mariet Allen, Lisa Alvarez, Liana G Apostolova, Steven E Arnold, Sanjay Asthana, Craig S Atwood, Sanford Auerbach, Gayle Ayres, Clinton T Baldwin, Robert C Barber, Lisa L Barnes, Sandra Barral, Thomas G Beach, James T Becker, Gary W Beecham, Duane Beekly, Bruno A Benitez, David Bennett, John Bertelson, Thomas D Bird, Deborah Blacker, Bradley F Boeve, James D Bowen, Adam Boxer, James Brewer, James R Burke, Jeffrey M Burns, Joseph D Buxbaum, Nigel J Cairns, Laura B Cantwell, Chuanhai Cao, Christopher S Carlson, Cynthia M Carlsson, Regina M Carney, Minerva M Carrasquillo, Scott Chasse, Marie-Francoise Chesselet, Nathaniel A Chin, Helena C Chui, Jaeyoon Chung, Suzanne Craft, Paul K Crane, David H Cribbs, Elizabeth A Crocco, Carlos Cruchaga, Michael L Cuccaro, Munro Cullum, Eveleen Darby, Barbara Davis, Philip L De Jager, Charles Decarli, John Detoledo, Malcolm Dick, Dennis W Dickson, Beth A Dombroski, Rachelle S Doody, Ranjan Duara, Nilüfer Ertekin-Taner, Denis A Evans, Kelley M Faber, Thomas J Fairchild, Kenneth B Fallon, David W Fardo, Martin R Farlow, Victoria Fernandez-Hernandez, Steven Ferris, Robert P Friedland, Tatiana M Foroud, Matthew P Frosch, Brian Fulton-Howard, Douglas R Galasko, Adriana Gamboa, Marla Gearing, Daniel H Geschwind, Bernardino Ghetti, John R Gilbert, Rodney C P Go, Alison M Goate, Thomas J Grabowski, Neill R Graff-Radford, Robert C Green, John H Growdon, Hakon Hakonarson, James Hall, Ronald L Hamilton, Oscar Harari, John Hardy, Lindy E Harrell, Elizabeth Head, Victor W Henderson, Michelle Hernandez, Timothy Hohman, Lawrence S Honig, Ryan M Huebinger, Matthew J Huentelman, Christine M Hulette, Bradley T Hyman, Linda S Hynan, Laura Ibanez, Gail P Jarvik, Suman Jayadev, Lee-Way Jin, Kim Johnson, Leigh Johnson, M Ilyas Kamboh, Anna M Karydas, Mindy J Katz, John S Kauwe, Jeffrey A Kaye, C Dirk Keene, Aisha Khaleeq, Masataka Kikuchi, Ronald Kim, Janice Knebl, Neil W Kowall, Joel H Kramer, Walter A Kukull, Frank M Laferla, James J Lah, Eric B Larson, Alan Lerner, James B Leverenz, Allan I Levey, Andrew P Lieberman, Richard B Lipton, Mark Logue, Oscar L Lopez, Kathryn L Lunetta, Constantine G Lyketsos, Douglas Mains, Flanagan E Margaret, Daniel C Marson, Eden Rr Martin, Frank Martiniuk, Deborah C Mash, Eliezer Masliah, Paul Massman, Arjun Masurkar, Wayne C Mccormick, Susan M Mccurry, Andrew N Mcdavid, Stefan Mcdonough, Ann C Mckee, Marsel Mesulam, Bruce L Miller, Carol A Miller, Joshua W Miller, Thomas J Montine, Edwin S Monuki, John C Morris, Shubhabrata Mukherjee, Amanda J Myers, Trung Nguyen, Thomas Obisesan, Sid O'Bryant, John M Olichney, Marcia Ory, Raymond Palmer, Joseph E Parisi, Henry L Paulson, Valory Pavlik, David Paydarfar, Victoria Perez, Elaine Peskind, Ronald C Petersen, Helen Petrovitch, Aimee Pierce, Marsha Polk, Wayne W Poon, Huntington Potter, Liming Qu, Mary Quiceno, Joseph F Quinn, Ashok Raj, Murray Raskind, Eric M Reiman, Barry Reisberg, Joan S Reisch, John M Ringman, Erik D Roberson, Monica Rodriguear, Ekaterina Rogaeva, Howard J Rosen, Roger N Rosenberg, Donald R Royall, Marwan Sabbagh, A Dessa Sadovnick, Mark A Sager, Mary Sano, Andrew J Saykin, Julie A Schneider, Lon S Schneider, William W Seeley, Susan H Slifer, Scott Small, Amanda G Smith, Janet P Smith, Joshua A Sonnen, Salvatore Spina, Peter St George-Hyslop, Takiyah D Starks, Robert A Stern, Alan B Stevens, Stephen M Strittmatter, David Sultzer, Russell H Swerdlow, Rudolph E Tanzi, Jeffrey L Tilson, John Q Trojanowski, Juan C Troncoso, Magda Tsolaki, Debby W Tsuang, Vivianna M Van Deerlin, Linda J Van Eldik, Jeffery M Vance, Badri N Vardarajan, Robert Vassar, Harry V Vinters, Jean-Paul Vonsattel, Sandra Weintraub, Kathleen A Welsh-Bohmer, Patrice L Whitehead, Ellen M Wijsman, Kirk C Wilhelmsen, Benjamin Williams, Jennifer Williamson, Henrik Wilms, Thomas S Wingo, Thomas Wisniewski, Randall L Woltjer, Martin Woon, Clinton B Wright, Chuang-Kuo Wu, Steven G Younkin, Chang-En Yu, Lei Yu, Xiongwei Zhu, Brian W Kunkle, William S Bush, Akinori Miyashita, Goldie S Byrd, Li-San Wang, Lindsay A Farrer, Jonathan L Haines, Richard Mayeux, Margaret A Pericak-Vance, Gerard D Schellenberg, Gyungah R Jun, Christiane Reitz, Adam C Naj, Alzheimer’S Disease Genetics Consortium (Adgc)

Faculty, Staff and Students Publications

Background: Limited ancestral diversity has impaired our ability to detect risk variants more prevalent in ancestry groups of predominantly non-European ancestral background in genome-wide association studies (GWAS). We construct and analyze a multi-ancestry GWAS dataset in the Alzheimer's Disease Genetics Consortium (ADGC) to test for novel shared and population-specific late-onset Alzheimer's disease (LOAD) susceptibility loci and evaluate underlying genetic architecture in 37,382 non-Hispanic White (NHW), 6728 African American, 8899 Hispanic (HIS), and 3232 East Asian individuals, performing within ancestry fixed-effects meta-analysis followed by a cross-ancestry random-effects meta-analysis.

Results: We identify 13 loci with cross-population associations including known loci at/near CR1, …

Sensing The Stiffness: Cellular Mechano-Sensing At The Implant Interface, Patricia S Pardo, Delia Danila, Raja Devesh Kumar Misra, Aladin M Boriek

Faculty, Staff and Students Publications

In this perspective, we highlight the relevance of the FA-Hippo signaling pathway and its regulation of the Yes-associated protein (YAP) and the transcriptional coactivator with a PDZ-binding domain (TAZ) as main players in the process of implants integration. The modulation and responses of YAP/TAZ triggered by substrate and ECM stiffness are of particular interest in the construction of materials used for medical implants. YAP/TAZ nuclear localization and activity respond to the substrate stiffness by several mechanisms that involve the canonical and non-canonical Hippo signaling and independently of the Hippo cascade. YAP/TAZ regulate the expression of genes involved in several mechanisms …

Development And Validation Of Risk Models For Hospital-Acquired Bleeding In Medical Inpatients: The Medical Inpatients Thrombosis And Hemostasis (Mith) Study, Neil A Zakai, Katherine Wilkinson, Andrew D Sparks, Ryan T Packer, Nicholas S Roetker, Allen B Repp, Mansour Gergi, Chris Holmes, Mary Cushman, Timothy B Plante, Hanny Al-Samkari, Allyson M Pishko, William A Wood, Camila Masias, Radhika Gangaraju, Ang Li, David Garcia, Kerri L Wiggins, Jordan K Schaefer, Nicholas L Smith, Augusto Ferraris, Karlyn A Martin, Deirdra R Terrell, Leslie A Mcclure

Faculty, Staff and Students Publications

Background: Hospital-acquired (HA) bleeding in medical inpatients is a serious complication with limited tools to predict risk.

Objectives: This study aimed to develop and validate risk assessment models (RAMs) for anatomic location-specific HA bleeding in medical inpatients using objective and routinely available risk factors.

Methods: Patients aged ≥18 years admitted to medical hospital services from 6 health systems and 15 hospitals in the United States between 2016 and 2020 for at least 1 midnight and without bleeding at admission were eligible for inclusion. Two health systems (10 hospitals) formed the development cohort, and 4 systems (5 hospitals) constituted the validation …

Prognostic Gene Expression And Microrna Profiling Signatures And Genetic Alterations In Primary Testicular Diffuse Large B-Cell Lymphoma, Wenyu Shi, Zijun Y Xu-Monette, Youchao Jia, Alexandar Tzankov, Heounjeong Go, Ling Li, Maurilio Ponzoni, Yafei Wang, Qiongli Zhai, Anamarija M Perry, Shi Wang, Xiaoxiao Wang, April Chiu, Mina L Xu, Carlo Visco, Karen Dybkaer, Henry Withers, Mark Long, Alyssa F Yuan, Yi Miao, Everardo Macias, Dehong Wu, Wen Shuai, Bangchen Wang, Jianyong Li, Govind Bhagat, Youli Zu, Zenggang Pan, William Choi, Santiago Montes-Moreno, Weina Chen, J Han Van Krieken, Michael B Møller, Xinfang Yu, Benjamin M Parsons, Shanxiang Zhang, Eric D Hsi, Aliyah R Sohani, Jeremy S Abramson, Andrés J M Ferreri, Bing Xu, Yong Li, Ken H Young

Faculty, Staff and Students Publications

Primary testicular (PT) diffuse large B-cell lymphoma (DLBCL) is a rare and aggressive lymphoma with distinct clinical and molecular characteristics. To identify prognostic biomarkers in PT-DLBCL, in this study we analyzed DNA and RNA samples of PT-DLBCL tumors from 206 patients using next-generation sequencing platforms and assays. Genetic alteration analysis found that multiple chromosomal copy number variations (CNVs), TP53 transcript mutations with high variant allele frequency, and MCD subtype had significantly adverse prognostic effects, whereas elevated microsatellite instability had a significantly favorable prognostic effect in PT-DLBCL. Targeted RNA-seq analysis identified a PTL gene expression signature by comparing PT-DLBCL with systemic …

Machine Learning Crime Prediction Models And The Gap Between Research And Implementation: A Systematic Review, Ricardo Huamantingo, Miguel Cano-Lengua, Ciro Rodriguez

Karbala International Journal of Modern Science

A crime is an illegal or violent act committed by one individual against another. The increasing crime rate has become a major concern as it negatively affects people's quality of life and generates significant social and economic costs. This study aims to identify the most widely used machine learning (ML) models for crime prediction, determine evaluation metrics for assessing model performance, and analyze key data characteristics to enhance real-world implementation. The study follows the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) methodology. A search string was formulated using the population, intervention, comparison, and outcomes (PICO) framework and applied …

Aku-Eb Student Awards

University anniversary celebration materials

No abstract provided.

The Clarity And Obscurity Of Inspired Writings: A Historical Survey From Late Antiquity To Early Nineteenth- Century America, Denis Kaiser

Andrews University Seminary Studies (AUSS)

Throughout Christian history, pastors, scholars, and church leaders have discussed whether, or to what extent, Scripture is clear or obscure. This article surveys the views on the clarity and obscurity of Scripture as advocated by Christian writers in five eras from late antiquity to early nineteenth-century America. Writers in the Protestant tradition have generally objected to the common notions among Roman Catholics that Scripture is obscure, consists of a four-fold sense, and that normative teaching authority is in the hands of the magisterium. Lutheran, Reformed, and Pietist scholars have generally emphasized the importance of having an educated clergy that understands …

Tantalizing Fragments Of A Larger Linguistic Tapestry: Exploring Nala Lambë, Mago/Magol, And The Dunlendish Languages In Tolkien's World-Building, Andrew Higgins

Journal of Tolkien Research

In this paper I pluck three leaves from my current research on Tolkien’s Tree of Middle-earth language invention - – Nala Lambë, Mago/Magol, and Dunlendish (also known as the Dunland Tongue). These lesser-known languages, despite their incomplete nature or "orphaned" status, underscore Tolkien's unwavering commitment to linguistic realism and the integral role of language in his sub-creation and world-building. They exist as both individual enigmatic leafs as well part of much larger tree of Tolkien’s linguistic world-building.

Need Frustration And Poor Mental Health Among Collegiate Athletes: The Indirect Role Of Ruminative Thinking, Alanni N. Brown, Adrian J. Bravo, Stimulant Norms And Prevalence 2 (Snap2) Study Team

Journal of Athlete Development and Experience

Vulnerability to negative mental health outcomes (i.e. anxiety and depression) among DI collegiate athletes may best be understood using Self Determination Theory (SDT) and the framework that need frustration impairs autonomy, competence, and relatedness. Need frustration may also relate to negative mental health symptoms via higher ruminative thinking, known to relate to both need frustration and poor mental health. The present study tested these two path models (i.e., SDT need frustration components [autonomy, relatedness, competency]-->rumination facets [problem-focused thoughts, counterfactual thinking, repetitive thinking, anticipatory thoughts]-->mental health problems (one for depression and one for anxiety as outcomes) among 341 collegiate …

Mentoring Of Para-Athletes And Its Impact On The Preparation Process For The 2020 Paralympic Games, Irina Perfilova, Joshua R. Pate, Robin Hardin

Journal of Athlete Development and Experience

Many factors contribute to successful athletic performance, and athletes have reported that mentors have played a vital role in their athletic performance as well as their personal development. Mentoring relationships can have a transformative impact on people’s lives, and mentored athletes, either by peers or coaches, have higher levels of dedication, confidence, and individual performance. Having a mentor is critically important during unexpected challenges in life such as was the case with the extraordinary uncertainty for para-athletes during the postponement of the 2020 Paralympic Games. The purpose of this study was to explore how mentoring aided para-athletes’ navigating the challenges …

Mrs. Sen’S Sense Of Cooking In Jhumpa Lahiri’S Interpreter Of Maladies, Fatma Yalvaç, Meryem Ayan

Khazar Journal of Humanities and Social Sciences

Mrs. Sen’s is one of the short stories in Jhumpa Lahiri’s short story collection Interpreter of Maladies (1999). In Mrs. Sen’s, Lahiri narrates the story of an Indian woman immigrating to a new country due to her husband’s occupation. Mrs. Sen has to leave her motherland and start a new life in a foreign country. She faces some difficulties in adapting to her new life away from India. For Mrs. Sen, the days, after moving to a foreign land, are surrounded by homesickness and loneliness. It can be observed that her reactions to these feelings are closely related to …

The Development And Psychometric Properties Of Climate Change Awareness Scale Among Higher Education Students, Şuay Nilhan Açikalin, Şefika Şule Erçeti̇n, Nihan Potas, Mehmet Sabir Çevik

Khazar Journal of Humanities and Social Sciences

Higher education has a pragmatic and educational approach to mitigating climate change and solving environmental challenges by enhancing awareness. Therefore, the study aims to develop a scale in a survey model to measure higher education students' awareness of climate change. The study group comprises higher education students enrolled at Public Universities in Ankara during the 2023-2024 academic year. For data analysis, exploratory factor analysis, confirmatory factor analysis, convergent and divergent (discriminant) validity, item analysis, and reliability analysis were employed. The scale was rigorously validated through exploratory factor analysis, confirmatory factor analysis, and other measures. As a result of the exploratory …