Digital Commons Network^™

Understanding The Physical Health Associations Of Intra-Individual Variability In Life Satisfaction Among Older Adults, Frosch Y. X. Quek, Kenneth Tan, David Chan

Research Collection School of Social Sciences

It is well established that inter-individual differences in life satisfaction positively predict health, but it is less clear how intra-individual variability in life satisfaction across time could influence health, particularly across individuals with different satisfaction levels. To address this gap, we analysed a large panel dataset from a national sample of 8,674 older adults, aged 50–70 (M = 59, SD = 5.42) in Singapore who completed surveys over 53 consecutive months. Results from multi-level modelling showed an interaction between variability in life satisfaction and life satisfaction mean on physical health. Specifically, there was no association between variability and health among …

Measuring What Matters: Towards Consequential Research, Lily Kong

Research Collection School of Social Sciences

In a commentary, SMU President Professor Lily Kong reflects on whether and how university researchers seek to make a societal difference, and how such impact can be assessed and recognised. Prof Kong notes that while many faculty members at SMU see the societal value of their work, the global academic system still lacks established frameworks to measure it. Prof Kong highlights SMU’s efforts to develop an approach that aligns with global trends yet is tailored to Singapore’s context, while acknowledging that international recognition still depends on adherence to common standards. She concludes that meaningful change will likely come when funding …

3r-Stadte Furs Leben Gestalten [Designing 3r Cities For Life], Lily Kong

Research Collection School of Social Sciences

What does it mean for a city to be resilient in today’s world? In July this year, over 100 city leaders, scholars, and industry partners gathered at City Dialogues in Vienna, co-convened by Singapore Management University and Urban Innovation Vienna, to reflect on the critical question of urban resilience. Held alongside the Mayors Forum of the World Cities Summit 2025, the dialogue provided a timely opportunity to share how cities can navigate complexity—not only in response to disruption, but also in pursuit of sustainable and inclusive futures. Inspired by SMU City Dialogues, I explore here how cities can bounce back, …

Full Circle: Historiography, Missiology, And Theology In Lin Yutang’S From Pagan To Christian, Teng-Kuan Ng

Research Collection College of Integrative Studies

Lin Yutang (1895–1976) is renowned for bridging the Chinese and Western worlds through his prolific writings, but the vital role of religion in his intercultural endeavors remains underappreciated. This article situates his seminal work of religious reflection, From Pagan to Christian (1959), within the context of World Christianity, defined as both movement and method. Lin’s departure from the Christianity of his youth into Chinese religions—and back again to the church in his later years—presents timely insights for the study of religious change and pluralism in global modernity. Analyzing the text’s decolonizing, dialogical, and polyphonic dimensions, this article brings Lin’s spiritual …

Direct And Indirect Experiences, Risk Perceptions, And Vaccine Booster Intention: A Mediation Study In Singapore Using Secondary Risk Theory, Sonny Rosenthal, Agnes S. F. Chuah, Hye Kyung Kim, Shirley S. Ho

Research Collection College of Integrative Studies

This study examined how direct experiences with COVID-19 infection and vaccination and indirect experience through government and media information predict individuals' intention to receive a COVID-19 booster dose. Drawing on secondary risk theory, we conducted a nationally representative door-to-door survey of 1000 adult Singapore residents in mid-2024. We used structural equation modeling to test whether risk perceptions and efficacy beliefs mediate the effects of experience and information exposure on booster intention. Booster intention was positively related to perceived susceptibility to infection, vaccine effectiveness, vaccination self-efficacy, and prior vaccination, and negatively related to perceived severity of and susceptibility to booster side …

Revealing Building Operating Carbon Dynamics For Multiple Cities, Winston Yap, Abraham Noah Wu, Clayton Miller, Filip Biljecki

Research Collection College of Integrative Studies

Achieving carbon neutrality is a critical yet elusive goal for many cities, hindered by limited understanding of the relationship between building emissions and their surroundings. To address this challenge, we present a generalizable open science framework that integrates building energy-consumption data, multi-modal geospatial inputs and graph deep learning to quantify building operating emissions and their links to urban form and socio-economic factors. Applying this approach to five cities with diverse climates and planning contexts—Melbourne, New York City (Manhattan), Seattle, Singapore and Washington DC—we demonstrate that our models explain 78.4% of the variation in building operating carbon emissions across cities, achieving …

Health And Weather In Unfavourable Environments: Exploring The Historical Dynamics Of Colonial Medical Meteorology In Nineteenth-Century Tropical Asia, Fiona Williamson

Research Collection College of Integrative Studies

Medical meteorology had a long precedent in medical thought across Eastern and Western traditions. This article considers the tradition of medical meteorology that was favoured by Western doctors in the nineteenth century, which was often applied within colonial contexts to the understanding of new climates and how they might impact on human health. Looking at British-held tropical and sub-tropical colonies of the Straits Settlements and Hong Kong respectively, medical meteorology was stimulated by the new pathological and atmospheric conditions that European explorers and settlers now inhabited in the name of the British Empire. They brought with them concepts of disease …

Enhancing The Value Of Satellite Earth Observations For Coastal Management: Tools For Collaboration And Co-Development, Nicole Dejeet Bartlett

Graduate Doctoral Dissertations

Despite unprecedented satellite Earth observation (EO) capabilities and free data availability, widespread adoption in coastal management remains limited due to persistent communication barriers between satellite experts and coastal practitioners. This dissertation addresses the fundamental challenge of translating satellite EO technical capabilities into management-relevant applications. Through synthesis of literature, stakeholder interviews, and two multi-year co-development case studies in Virginia's Middle Peninsula and Cape Cod, Massachusetts, this research identifies systematic barriers to satellite EO adoption and develops innovative frameworks for overcoming them.

The work argues for a common language between satellite product developers and coastal managers, identifying communication barriers spanning technical, institutional, …

Enhancing Non-Visual Interaction With Online User-Generated Content, Mohan Krishna Sunkara

Computer Science Theses & Dissertations

The Web has become the dominant medium for our everyday activities, including communication, business, e-commerce, news, and entertainment. Consequently, the online world is experiencing an explosion of User-Generated Content (UGC), particularly on social media platforms and online review systems. To facilitate convenient interaction with UGC, web platforms have adopted various presentation strategies that enable users to efficiently browse and contribute to the UGC. However, these user interfaces are primarily designed for sighted individuals, so they do little to assist blind users who rely predominantly on audio-based screen reader assistive technology. The extant efforts to improve web interaction for blind users …

School Counselor Burnout And Self-Efficacy And Their Impact On The Degree Of Implementation Of A Comprehensive School Counseling Program, Rebecca Pierre-Louis

Counseling & Human Services Theses & Dissertations

School Counselors are educators who are vital in supporting students’ educational development. School Counselors do this by delivering a comprehensive, developmentally appropriate, and prevention-oriented school counseling programs that provide direct, indirect, and responsive services to support students’ career, academic, and social/emotional development. School Counselors do this while often experiencing an expanded definition of their role within a school building. While research supports the benefits of comprehensive school counseling programs to schools and students, school counselors often face large student caseloads. As well, they are tasked with many non-school counseling duties, which hampers the delivery of a comprehensive school counseling program. …

Examining The Impact Of A Utility Value Intervention On Self-Regulated Learning Engagement, Wanda D. Brooks

STEMPS Theses & Dissertations

The purpose of this study was to examine the impact of inserting a motivation intervention into a self-regulated learning training in an introductory biology course to increase academic performance and persistence to degree completion in science. The study was an experimental design with pre- and post-tests, with treatment and comparison groups. The training was in the form of three self-regulated learning cycles presented to students on a Blackboard Organization site where students were asked to record self-regulated learning activities in a journal during training. The primary aim of the intervention was to increase engagement in the self-regulated learning training by …

Empowering The User Through Inclusive Technical Writing, Robert Enriquez

English Theses & Dissertations

This thesis examines the issues in technical writing due to a disconnect between writer and reader/user. I am basing this study on my real-life job. I am a manager at a well-known sneaker retailer. In August 2024, there was a Workforce Management (WFM) software that the sneaker retailer launched in the retail stores. The WFM itself was glitched and unfinished. Not much disclaimer, training or preparation was given other than these procedural documents the sneaker retailer gave. If all the store managers had to depend on was technical documentation to prepare for this already glitched WFM, then I argue there …

Predictors Of Healthcare Providers' Readiness For Health System Transformation In Saudi Arabia, Ahmed Ali Alasiri

Health Services Research Dissertations

The healthcare system in Saudi Arabia is undergoing significant health reform to warrant sustainable welfare provision. Privatization or public-private partnerships (PPPs) were introduced in 2021 and outlined the vision for the health system for 2023. The planned initiatives aim to be comprehensive and effectively reach individuals and society, including citizens, noncitizens, and visitors. This dissertation seeks to study and explore privatization, the role of healthcare providers, and their capacity to adapt to the transformation of the healthcare system. To achieve this ambitious goal, several interrelated projects have been undertaken. The first project was a systematic review aimed at studying the …

Explanations For Racial Inequality In America; Effects Of Protestant Beliefs, Behaviors And Region, Qurshonda Shannae Lomans

Sociology & Criminal Justice Theses & Dissertations

The founder of the Center for the Study of Social Policy in Washington DC, Tom Joe (1987) released an article examining economic disparities between Black and White Americans. Across the measures of income, poverty and unemployment rates, Black Americans were found to be at an economic disadvantage. According to current data published by the U.S. Department of Commerce (2018), the economic wealth gap has remained unequal. Prior research examining racial inequality has found Protestantism to be a foundation from which Americans form their ideologies about social issues (Hunt, 2007; Edgell & Tranby, 2007; Taylor & Merino, 2011). Data provided by …

Graduate Students’ Perspectives On Universal Design For Learning (Udl) 3.0 Guidelines: A Q-Methodology Study, Taylor C. Rodriguez

Educational Leadership & Workforce Development Theses & Dissertations

The purpose of this study was to explore graduate students’ perspectives of Q-methodology to understand their insights on the newly updated Universal Design for Learning (UDL) 3.0 guidelines and how they feel these guidelines support their academic journey. A Q-sort instrument consisting of 36 statements aligned with UDL 3.0 principles was administered to graduate students at the master’s and doctoral levels. Thirty-two participants completed the Q-sort activity, and factor analysis revealed four distinct viewpoints reflecting varied perceptions of UDL’s relevance and impact within graduate education.

Findings indicate areas of consensus among students, particularly regarding the importance of developing student autonomy …

Exploring The Relationship Between Cannabis Use Motives And Readiness To Change Among Young Adult College Students, Emma Kathryn Rawls

Psychology Theses & Dissertations

Cannabis use among young adult college students has risen steadily over the past decade, raising concerns about the associated health, academic, and psychological consequences. While cannabis use motives and readiness to change have each been linked to use patterns and outcomes, limited research has examined how these factors interact. The current study investigated whether readiness to change, based on the Transtheoretical Model (TTM), moderates the relationship between cannabis use motives and cannabis-related consequences as well as past-30-day use frequency. A sample of 100 college students 18-25 years old (M_age = 20.08, SD = 2.12; 67% female; 55.0% Black or …

Intersecting Realities And Evolving Landscapes: Mapping Generative Ai Within The Framework Of Digital Rhetoric, Joshua Troy Nieubuurt

English Theses & Dissertations

The increased usage of [Generative] AI technologies (GenAI) in the 21st century has called into the question the rhetorical agency of these digital things. [Gen]AI has historically been framed within a Heideggerian “readiness-to-hand” dynamic in which it has been unilaterally conceived as a tool to be used by humans. This dissertation proposes that the GenAI assemblage is capable of being a co-actor in rhetorical spaces. To provide evidence for this stance This dissertation utilizes Actor Network Theory to map the actants within a GenAI assemblage. In doing so it allows for an understanding of the stakeholders (both human and non-human) …

The Psychological Constructs Of International Graduate Students Transitioning To A University In America: A Thematic Analysis, Umadevi Ramesh

Doctoral Dissertations

This dissertation employed a qualitative analysis methodology to explore the experiences of first-time international graduate students during their transition to university, focusing on initial adjustment, perceived support, perceived discrimination, and mental well-being. Previous studies about international student experience have mainly focused on undergraduate students. Furthermore, few have examined the initial transition period to university and factors involved in both positively and negatively impacting students’ adjustment process as well as overall psychological well-being. Nine participants qualified for inclusion in the present study and participated in semi-structured interviews, which the researcher analyzed using a thematic analysis framework. Participants expressed a strong need …

Adaptations To Family-Based Treatment For Medicaid-Insured Adolescents With Anorexia Nervosa, Renee Borges

Doctoral Dissertations

Background: Family-based treatment (FBT) is the leading intervention for adolescents with anorexia nervosa (AN), however it is under researched in socioeconomically disadvantaged and racially diverse youth.

Methods: Semi-structured interviews were completed with ten FBT clinicians who practice in publicly-funded settings. Interview questions were focused on implementation challenges, overall acceptability and appropriateness of FBT, and naturally-occurring treatment adaptations.

Results: Content analysis revealed common themes relating to the implementation of FBT in publicly-funded, community-based settings: acceptability and appropriateness, complexity and learnability, perceived core components of FBT, cultural adaptations, socioeconomic factors, logistical considerations, organizational and systemic barriers, training acceptability, participant’s self-efficacy, and telehealth …

Inclusion, Diversity, Equity, And Access Annual Report, Fiscal Year 2025, April Anderson-Zorn, Emily Baldoni, Karmine Beecroft, Chad E. Buckley, Susan Franzen, Tom Hardy, Ellie Harman, Laura Killingsworth, Heather Koopmans, Maddi Loiselle, Joshua Newport, Ryan Peters, Seth Peterson, Lindsey Skaggs, Caitlin Stewart, Maria Tudela, Eric Willey, Angela Yon

Reports and White Papers - Milner Library

Report of Milner Library's activities and initiatives related to Inclusion, Diversity, Equity, and Access in Fiscal Year 2025. Compiled by the IDEA Committee.

Optimization Of Mhealth Behavioral Interventions For Patients With Chronic Lymphocytic Leukemia: The Health4cll Study, Che Young Lee, Max J Gordon, Melissa M Markofski, Emily C Lavoy, Susan K Peterson, Liang Li, Sara Fares, Miranda Baum, Margaret Pace, Danielle Walsh, Alessandra Ferrajoli, Karen Basen-Engquist

Faculty, Staff and Student Publications

Purpose: This pilot study of a diet and physical activity intervention (HEALTH4CLL) was conducted to reduce fatigue and improve physical function (PF) in patients with chronic lymphocytic leukemia (CLL).

Methods: The HEALTH4CLL study used a randomized factorial design based on the multiphase optimization strategy (MOST). Patients received diet, exercise, and body weight management instructional materials plus a Fitbit and were randomized to undergo one of 16 combinations of 4 evidence-based mHealth intervention strategies over 16 weeks. Patients' fatigue, PF, health-related quality of life, behavior changes, and program satisfaction and retention were assessed. Paired t-tests were used to examine changes in …

Language Barriers In Accessing Healthcare Services For Refugees In The United States, Sadaf Khuram

Communication & Theatre Arts Theses

Accessing healthcare is a pivotal aspect of refugees' integration into their host countries and significantly impacts their long-term health outcomes. The literature emphasizes the critical role of language proficiency in overcoming communication barriers within healthcare settings. This thesis, however, challenges the assumption that addressing language barriers alone is universally sufficient. It argues that the importance of language solutions is context-dependent, varying with the design of healthcare systems and the diverse needs and backgrounds of refugees. In some cases, focusing primarily on language barriers can divert resources from other critical areas, particularly when healthcare facilities have limited capacities or when services …

Service With A Smile Or Salesperson Mirroring? Understanding The Flow Of Emotional Contagion In Sales Encounters, Vinh Quoc Trong Luong

Theses and Dissertations in Business Administration

This study examines the directionality of emotional contagion in sales interactions, addressing a critical gap in understanding whether emotions flow primarily from the salesperson to the customer, from the customer to the salesperson, or bidirectionally. While prior research emphasizes customer-driven emotional flow or bidirectional alignment, this study challenges these assumptions by employing categorical Cross-Recurrence Quantification Analysis (CRQA) to assess temporal emotional synchronization in sales dialogues. Leveraging automated sentiment analysis and multi-agent AI evaluation for performance metrics, the research analyzes 166 sales interactions to quantify emotional influence dynamics. Results reveal that salespeople predominantly lead emotional exchanges, exhibiting stronger and more stable …

Master Protocol Design With Hybrid Control For Efficient Early-Phase Trial Consolidation, Alexander M Kaizer, Xiaojiang Zhan, Eric Baron, Rui Sammi Tang, David S Hong, Brian P Hobbs

Faculty, Staff and Student Publications

Purpose: Master protocols represent transformations, enabling multiple therapies or diseases under a single protocol. These designs streamline therapeutic development by reducing redundancies. Suited for evolving fields such as oncology and global emergencies such as the COVID-19 pandemic, master protocols have been exemplified by studies such as RECOVERY, Solidarity, and I-SPY 2, which accelerated effective treatment identification (with I-SPY 2 focused on molecular subtypes). Recent oncology examples, such as MORPHEUS, evaluate immunotherapy combinations with shared controls. Despite advantages, their application in early-phase oncology remains underutilized amid growing regulatory emphasis on randomization for robust evidence.

Methods: US Food and Drug Administration (FDA) …

Nanotechnology For Immuno-Oncology, Adam J Grippin, Daeyong Lee, Eileen E Parkes, Wen Jiang, Betty Y S Kim

Faculty, Staff and Student Publications

Although the first generation of cancer immunotherapeutics produced unprecedented improvements in clinical outcomes for individuals with cancer, novel strategies to increase treatment specificity, delivery efficiency and pharmacokinetics are still needed. In this Review, we describe the potential advantages and current limitations of nanomaterials for cancer immunotherapy and highlight rational uses of nanosystems to generate potent and durable antitumor immune responses. We close with a review of the current state of clinical development of nanomedicine for cancer immunotherapy.

A Phase 2 Trial Of Cpx-351 Combined With Venetoclax In Relapsed Or Refractory Acute Myeloid Leukemia, Tapan M Kadia, Wei-Ying Jen, Alex Bataller, Alexandre Bazinet, Gautam Borthakur, Elias Jabbour, Wei Qiao, Nicholas J Short, Koichi Takahashi, Ghayas C Issa, Courtney D Dinardo, Guillermo Montalban-Bravo, Naveen Pemmaraju, Andrew Tran, Vanthana Bharathi, Sanam Loghavi, Amin M Alousi, Uday Popat, Naval G Daver, Farhad Ravandi, Hagop M Kantarjian

Faculty, Staff and Student Publications

Outcomes in patients with relapsed/refractory (RR) AML are poor. We sought to investigate if CPX-531 in combination with venetoclax (CPX + VEN) was tolerable and effective in RR AML. This was a single institution phase 1b/2 trial of CPX + VEN. Patients aged ≥ 18 years with RR AML who were fit for intensive chemotherapy were eligible. Prior venetoclax exposure was allowed. The phase 1b portion followed a 3 + 3 design to identify the recommended phase 2 dose (RP2D) for the expansion cohort. At the starting dose level of −1, prolonged myelosuppression was observed, leading to dose level −2 …

Perioperative Durvalumab Plus Chemotherapy Plus New Agents For Resectable Non-Small-Cell Lung Cancer: The Platform Phase 2 Neocoast-2 Trial, Tina Cascone, Laura Bonanno, Florian Guisier, Amelia Insa, Moishe Liberman, Olivier Bylicki, Lorenzo Livi, Thomas Egenod, Romain Corre, Dong-Wan Kim, Maria Rosario Garcia Campelo, Mariano Provencio Pulla, Byoung Yong Shim, Giulio Metro, Jaafar Bennouna, Agata A Bielska, Alula R Yohannes, Yun He, Adam Dowson, Gozde Kar, Lara Mcgrath, Rakesh Kumar, Italia Grenga, Jonathan Spicer, Patrick M Forde

Faculty, Staff and Student Publications

In the phase II NeoCOAST-2 platform study, 202 patients with untreated, resectable stage IIA–IIIB non-small-cell lung cancer (NSCLC) were randomized to receive neoadjuvant durvalumab plus platinum-doublet chemotherapy with oleclumab, a CD73 inhibitor (Arm 1), or with monalizumab, a NKG2A inhibitor (Arm 2), or neoadjuvant durvalumab plus single-agent platinum chemotherapy with the TROP-2 antibody–drug conjugate (ADC) datopotamab deruxtecan (Arm 4), followed by surgical resection and adjuvant durvalumab with oleclumab or monalizumab (Arms 1 and 2) or durvalumab alone (Arm 4). Primary endpoints were pathological complete response (pCR) rate and safety; secondary endpoints included feasibility of surgery and major pathological response (mPR) …

Gd3 Synthase Drives Resistance To P53-Induced Apoptosis In Breast Cancer By Modulating Mitochondrial Function, Vivek Anand, Fouad El-Dana, Natalia Baran, Jenny Borgman, Zheng Yin, Hong Zhao, Stephen T Wong, Michael Andreeff, V Lokesh Battula

Faculty, Staff and Student Publications

TP53 mutations are common in breast cancer (BC) and are associated with poor prognosis. GD3 synthase (GD3S/ST8SIA1), a gene associated with breast cancer stem cells, is upregulated in tumors with p53 mutations. However, the functional relationship between GD3S and p53 is unknown. Here, we show that GD3S levels are highest in breast tumors with specific p53 mutations. Functional studies revealed that wild-type (WT) p53 inhibits GD3S expression, whereas mutation in p53 enhances GD3S expression by upregulating GD3S promoter activity. Moreover, we found that GD3S inhibits wild-type p53-induced apoptosis in BC cells, while BC cells harboring gain-of-function p53 mutations are dependent …

Summit Max: A Randomized Trial Of The Super Large Bore Hipoint Reperfusion System Versus Vecta System For Aspiration Thrombectomy., Thanh N Nguyen, Guilherme Dabus, Ben Mcguinness, James Caldwell, Ryan Priest, Ansaar T Rai, Osama O Zaidat, Bradley A Gross, Ricardo Hanel, Shane Lee, Shazam Hussain, Hamza Shaikh, Mohamad Abdalkader, Ronald Budzik, Craig Kilburg, Keith Woodward, Marco Colasurdo, Jesse Liu, Albert J Yoo, Priyank Khandelwal, Sohyun Boo, Phong Vu, Eugene Lin, Mohammad Almajali, Jasmeet Singh, Alhamza Al-Bayati, Michael J Lang, Michael Abraham, Ameer E Hassan, Peter Pema, Coleman Martin, Ramesh Grandhi, Daniel A Tonetti, Harry R Hixson, Amin Aghaebrahim, Eric Sauvageau, Santiago Ortega-Gutierrez, Dileep R Yavagal, Esteban Cheng-Ching, Jane Khalife, Italo Linfante, Volodymyr Vulkanov, Jazba Soomro, Johanna T Fifi, Lucien Maidan, Alexander Copelan, Clemens M Schirmer, Mark Bain, Gabor Toth, Mahesh Jayaraman, Roberta Novakovic-White, Sudhakar Satti, Nicolas Villelli, Pascal Jabbour, Matthew Page, Davina J Mcallister, Robert Araujo Contreras, Edgar A Samaniego, David S Liebeskind, Steven W Hetts, Raul G Nogueira, Joey English, Ajit S Puri

Neuroscience Articles

BACKGROUND: Rapid and complete recanalization is a primary goal in the endovascular treatment of large vessel occlusion stroke. The effectiveness and safety of super large bore aspiration catheters (0.088″ inner diameter) for the treatment of large vessel occlusion stroke have not been demonstrated in a randomized trial.

METHODS: SUMMIT MAX (A Prospective, Randomized, Controlled, Interventional Clinical Trial to Evaluate the Safety and Effectiveness of the Route 92 Medical MonoPoint Reperfusion System for Aspiration Embolectomy in Acute Ischemic Stroke Patients) was a prospective, randomized, controlled, open-label clinical trial of patients with internal carotid artery and middle cerebral artery M1 occlusions, comparing …

Advancing File System Model Checking: Coverage, Framework, And Scalability, Yifei Liu

Electronic Dissertations and Theses, 2010-current

File systems serve as the foundation for data storage and access, making their reliability crucial to maintaining system correctness and data integrity. However, building robust file systems remains a significant challenge. Despite numerous testing and verification techniques, file system bugs continue to emerge. To detect file system bugs and improve reliability, we tackle three key aspects: new coverage metrics for testing, a novel model checking approach, and enhanced scalability for file system verification. We begin by introducing input and output coverage (IOCov) as metrics for evaluating and improving file system testing, along with IOCov to compute them. We integrated IOCov …