Digital Commons Network^™

Amputation Trends Among People Who Use Drugs In The Context Of Philadelphia’S Increasingly Xylazine Adulterated Drug Supply, Rose Laurano, Monika Pogorzelska-Maziarz, Traci C. Green, Sara Beachy, Kristin L. Rising, Jeffrey K. Hom, Megan K. Reed

Jefferson Center for Connected Care Faculty Papers

BACKGROUND: Xylazine-adulterated fentanyl has rapidly spread across the United States and has been increasingly detected in overdose deaths in Philadelphia, PA through medical examiner reports, clinical testing, and widescale drug checking. Xylazine use has been associated with wounds which may lead to amputation, but the extent of this outcome has not been explored.

METHODS: Utilizing the 10th revision of the International Classification of Diseases (ICD-10) codes, we conducted a de-identified retrospective analysis of data for patients identified with opioid related disorders (ICD-10 code F11) admitted to four different hospitals in Philadelphia, PA between 2018 and 2023. Exposure to xylazine use …

"Driving Circles Around The Holler:" Liminality And The Grotesque In Donald Ray Pollock's Knockemstiff, Celia A. Ranniger

Electronic Theses and Dissertations

Donald Ray Pollock’s 2008 short story cycle, Knockemstiff, is a regionalist work of grotesque Grit Lit featuring characters from a small, rural holler community in southern Ohio. This work examines the form, narratives, and characters through close reading, illuminating the layers of different liminalities present in the cycle. These liminalities include narrative liminality of the form of the short story cycle, the social and economic liminal spaces inhabited by the characters, and the ways that the text comments on the liminal nature of storytelling itself. This thesis will argue that the geography of the cycle’s setting coupled with the subject …

Enhancing Digital Health Development Through Speech Act Theory: Application To Peripartum Depression Management, Alexandra Zingg, Tavleen Singh, Michael Truong, Sahiti Myneni

Faculty, Staff and Student Publications

The peripartum period is a time of complex transition into motherhood when women may develop peripartum depression (PPD). Digital information sources can help prevent and monitor symptoms through social support and mental health knowledge. However, few studies have characterized the content and form of peer interactions in PPD online forums to inform interventions. In this paper, we present preliminary work using a dataset of 55,301 interactions to inform our digital health development. We combine manual coding for speech acts, behavioral theory mapping, and user engagement modeling to conceptualize dynamic digital education modules for PPD. Results reveal "Expressive" speech act, where …

Towards Data-Driven Science Literacy: Extracting Psycholinguistic Markers In Vaping-Related Online Peer Interactions, Michael Truong, Ahmed Abdelhameed, Tavleen Singh, Kirk Roberts, Sahiti Myneni

Faculty, Staff and Student Publications

Social media debates on e-cigarettes raise public health concerns due to evolving evidence and conflicting guidelines. We analyzed 25,127 vaping-related comments to explore how users discuss vaping-related topics. Our analysis revealed 25 topics grouped into three parent topics: positive effects of vaping, negative effects of vaping, and vaping-related news & information. Significant differences were observed in psycholinguistic characteristics with high emotional exchanges as positive and negative effects of e-cigarettes are debated. Our results can inform interventions promoting science literacy and misinformation resistance.

Efficient Training Corpus Retrieval For Large Language Model Fine Tuning: A Case Study In Cancer., Avisha Das, Chiamaka Diala, Guocai Chen, Zhao Li, Rongbin Li, Omer Anjum, W Jim Zheng

Faculty, Staff and Student Publications

The objective is to create an automated knowledge extraction tool for cancer research that builds high-quality academic corpora for LLM fine-tuning while investigating its effectiveness in interleukin-6 and bladder cancer domains. To address the current gap in knowledge retrieval techniques for cancer research data collection, we propose KnowledgePipeline, a novel automated tool that incorporates diverse aspects of academic papers and metadata. Our tool integrates content, co-citations, and co-authorship networks to construct domain-specific academic corpora suitable for fine-tuning LLMs. We leverage two LLMs (GPTJ-6.7B and Galactica30B) trained on domain-specific question-answer pairs from the refined data. The system's evaluation focuses on both …

Lysosomes As Gatekeepers: How Lic1-Mediated Trafficking Regulates Angiogenesis And Vascular Morphogenesis, Dymonn Johnson

Arts & Sciences Graduate Student Theses and Dissertations

Dynein cytoplasmic 1 light intermediate chain 1 (LIC1, DYNC1LI1) is a core subunit of the dynein motor complex that plays a critical role in cytoplasmic cargo trafficking, including Rab-mediated endosomal recycling and lysosomal degradation. LIC1 interacts with various cargo adaptors, such as RILPL1 and RILPL2, to regulate these processes, and defects in this gene are predicted to impair dynein motor function, Rab binding, and lysosomal trafficking. Here, we identified a dync1li1 zebrafish mutant with a premature stop codon at the exon 12/13 splice acceptor site, that exhibits increased angiogenesis. In vitro, LIC1-deficient human endothelial cells show elevated cell surface levels …

The Illusion Of “El Chingon”: A Scoping Review On How Machismo Affects Mental Health And Behavior, Vanessa Estrada Garza

McNair Summer Research Program

Machismo is a set of cultural values tethered to the gender binary, defined by the specific gender roles and expectations that men have to act upon. These ideals create a male archetype based on aggression, stoicism, superiority, and the enabling of sexist attitudes. Research has shown that rigid hypermasculine attitudes have a negative effect on mental health (e.g., depression and anxiety symptoms) and behavior (e.g., aggression and substance abuse). However, given its cultural context, much less is known about how machismo may manifest based on different demographic variables. Therefore, the goal of this scoping review was to understand the relation …

Streamlined Technology Systems: Optimizing Technology Systems For Meridian Public School District, Latoya Atterberry

Theses and Dissertations

Technology has become a cornerstone of modern education, reshaping how teachers instruct and students learn. "Technology plays a pivotal role in shaping modern learning environments, offering opportunities for enhanced engagement and personalized learning experiences" (Ascione, 2023). This project focuses on the critical role of effective professional development in equipping teachers to integrate technology into their instructional practices meaningfully. Drawing on the TPACK (Technological Pedagogical Content Knowledge) and SAMR (Substitution, Augmentation, Modification, Redefinition) frameworks, this project examines how tailored professional development programs can bridge gaps in teachers’ technological and pedagogical knowledge, guiding them toward transformative technology use. This project culminates in …

Soil Ethics In Practice: Harvesting Conservation Choices Among Puerto Rican Coffee Farmers, Patricia Marie Cordero-Irizarry

Theses and Dissertations

Coffee farming in Puerto Rico has declined over recent decades, partly due to deteriorating soil quality. However, the decision-making process behind farmers’ adoption of soil conservation practices remains unclear, particularly the overlooked role of soil ethics, which emphasizes the moral principles guiding human relationships with the soil. This mixed-methods study examined coffee farmers’ adoption of soil conservation practices by integrating the Values-Beliefs-Norms (VBN) theory and a newly developed Soil Ethics Survey (SES) instrument for the quantitative component, while using Decision-Making Theory and Social Cognitive Theory to qualitatively explore how farmers’ experiences and reflections shape their soil ethics. Quantitative findings revealed …

Improving Engagement Through Readers' Theater: A Systematic Literature Review And Teacher Process Portfolio With Program Proposal, Karen K. Crum

Theses and Dissertations

This project investigated the impact of Readers’ Theater on elementary students’ attitudes toward reading, the teacher’s perception of effectiveness of Readers’ Theater as a tool to improve reading comprehension, and students’ test-related anxiety, within the context of the Mississippi Academic Assessment Program (MAAP) mandated by the Literacy-Based Promotion Act. While existing literature has highlighted Readers’ Theater as an effective instructional strategy that engages reluctant readers and enhances both reading fluency and comprehension through repeated, performance-based readings, gaps in current research exist regarding Readers’ Theater effectiveness as an instructional strategy to mitigate reading- and test-anxiety. Through research questions focused on how …

Regulating Artificial Intelligence In The U.S.: A Historical-Innovation-Inspired Framework, Di Kevin Gao

Theses and Dissertations

The emergence of OpenAI\textquotesingle s ChatGPT has marked the dawn of a new Artificial Intelligence (AI) era, unleashing a wave of user excitement, moral panic, and apocalyptic warnings. Yet, these concerns have done little to slow the breakneck pace of AI development and deployment. Should the United States adopt the European Union\textquotesingle s top-down, legislation-first approach, or follow the United Kingdom\textquotesingle s bottom-up, court-driven model? This research draws from historical legislative parallels in the U.S. By examining past regulatory frameworks for disruptive technologies, including electricity, automobiles, the telephone, broadband internet, nuclear technology, cryptocurrency, commodity futures, modern pharmaceuticals, and social media, …

Documenting Children’S Use, Physical Activity, And Social Play In Tom Lee Park’S Playscape, Laurel Kelton

Theses and Dissertations

The benefits of nature and physical activity on children’s health and development are well documented. However, many children lack access to nature and physical activity. Researchers have found that “innovative playgrounds” —which, by definition, are more likely to include natural elements that facilitate nature immersion— are associated with increased physical activity and duration of stay. This thesis is a case study of a public innovative playground at Tom Lee Park. It sought to understand the playground’s areas and physical characteristics that have higher levels of use, physical activity, and social play and longer durations of stay. Data was collected over …

My Grandparents Raised Me: The Role Of Formative Individual And Family Experiences In Predicting Emerging Adult Substance Use, Attachment, And Mental Health Outcomes, Acacia Lopez

Theses and Dissertations

Individuals raised in a grandfamily, or family structure in which a grandparent raises their grandchildren, experience higher rates of adverse childhood experiences (ACEs), insecure attachment, and negative mental health outcomes during childhood. Literature on outcomes of these individuals across the lifespan is extremely limited, however, and it is unclear how formative individual and family experiences of being raised by grandparents carry into emerging adulthood (e.g., 18 to 25-years-old). Emerging adulthood is a developmental stage marked by significant instability and unpredictability that is linked with increased vulnerability to mental health concerns and substance use. It has been identified as an important …

Family Matters: How Caregiver Influence And Internal Locus Of Control Relate To Academics, Maia Mclin

Theses and Dissertations

Academics in college predicts life outcomes; students from lower socioeconomic status (SES) backgrounds often face greater challenges. One such population, consisting of many individuals from marginalized backgrounds, are those raised by nontraditional parents. This study investigated predictors of academics among 357 college students, examining authoritative parenting style, intrinsic motivation, academic locus of control (LoC), SES, and caregiver type (parental vs. non-traditional). Academics was assessed using two composite scores: 'academic knowledge' (GPA/ACT) and 'compensatory attention' (working memory via n-back task accuracy and attention/concentration via SMALSI-C). Hierarchical regressions revealed that higher authoritative parenting, higher SES, and being raised by biological parents significantly …

Expanding Access: A College Access Model For English Learners, Amanda Blackwell Mcleod

Theses and Dissertations

As one of the fastest-growing student populations in K -12 schools, English Learners (EL)s remain significantly underrepresented in postsecondary education. Barriers such as academic preparedness, financial constraints, and sociocultural factors hinder their access to postsecondary education. However, by developing targeted strategies to assist ELs in accessing and completing college, institutions can address these challenges and ensure a more diverse and sustainable student body in the face of declining enrollment. Effective models for helping EL students access college include family engagement, early college exposure, peer mentorship, and student-centered advising. By assisting ELs in accessing college, institutions can strengthen their enrollment efforts, …

In Good Times & Bad: Measuring Ambivalence In Custodial Grandparents, Marin Gail Olson

Theses and Dissertations

Like other forms of caregivers, custodial grandparents experience both the joys and trials of raising their grandchildren. This culmination of positive and negative feelings is called “caregiver ambivalence." It has only recently been studied in relation to caregiver burden and wellness in the form of caregiver ambivalence theory (CAT). By collecting data from approximately 395 custodial grandparents via an online survey, the current study aimed to test if custodial grandparents’ feelings of burden influence their perceived well-being and if feelings of ambivalence mediate this relation. Implications of this research include identifying areas of strength and growth within custodial grandparents and …

Mastering Skills Together: Effects Of Video Modeling On Parent-Implemented Academic Intervention, Chelsea S. Thorpe

Theses and Dissertations

Reading proficiency is a fundamental skill for academic success and long-term developmental outcomes. Yet, despite ongoing efforts to strengthen literacy education, a significant number of students continue to face reading difficulties that hinder comprehension, critical thinking, and overall academic achievement. National data demonstrate the urgency of this issue. The 2024 National Assessment of Educational Progress (NAEP) reported that 40% of fourth-grade students and 33% of eighth-grade students scored below the Basic level in reading, marking the highest rate on record for eighth graders. Early reading challenges can often lead to other academic and psychosocial challenges such as low achievement, low …

Academics Vs Athletics: Prioritizing The Students In Student-Athletes And The Importance Of Their Return To The Classroom, Stephen Walker

Theses and Dissertations

The Mississippi High School Activities Association (MHSAA) aims to enhance student- athletes' educational experiences but Law 6.5.1 inadvertently causes students to miss 300 hours of academic instruction annually. This dilemma forces school districts to choose between robust sports programs and rigorous academic schedules, ultimately creating a disadvantage for students. While participation in sports has been linked to improved academic performance, the current structure disproportionately allocates resources to athletics over academics, with only 51% of schools offering after-school academic programs compared to 77% for sports. This paper discusses the benefits of sports, including higher attendance and graduation rates, but also highlights …

Adipokines And Transitions In Metabolic Health Over Time: The Atherosclerosis Risk In Communities (Aric) Study, Bige Ozkan, Sui Zhang, Justin B Echouffo-Tcheugui, Roberta Florido, Vijay Nambi, Erin D Michos, Layla A Abushamat, Kunihiro Matsushita, Gary Gerstenblith, Roger S Blumenthal, Ron Hoogeveen, Christie M Ballantyne, Josef Coresh, Elizabeth Selvin, Chiadi E Ndumele

Faculty, Staff and Students Publications

Context: Transitions in metabolic health status over time are strongly linked to risk for cardiovascular events, particularly among individuals with obesity. Adipokines are proteins with metabolic effects, but their role in transitions in metabolic health status over time is unknown.

Objective: To evaluate the associations of adiponectin and leptin with metabolic risk transitions over time.

Methods: Among 8423 individuals who attended ARIC Visits 2 (1990-1992) and 4 (1996-1998), we evaluated prospective associations of Visit 2 levels of the adipokines adiponectin and leptin (per 1-SD higher) with 6-year transitions in metabolic health. Metabolic health was categorized as metabolically "healthy" [no metabolic …

Urinary Pneumococcal Serotype Detection Among Children With And Without Community-Acquired Pneumonia, Lilliam Ambroggio, Lindsay R Grant, Jillian M Cotter, Samuel R Dominguez, Daniel Olson, Sara R Saporta-Keating, Cody Bender, Mohammad Ali, Kathleen Grice, Gonzalo Lerner, Michael W Pride, Ashley Miller, Maria J Tort, Annaellis Vaughan, Elizabeth Temte, Alec Edid, Alejandro Cané, Kristina G Hulten, Jill Stein, Bradford D Gessner, Edwin J Asturias

Faculty, Staff and Students Publications

Background: Urinary antigen detection (UAD) assays can address diagnostic challenges with culture-based identification of S. pneumoniae. We aimed to evaluate the utility of Pfizer's UAD1 and UAD2 assays for pneumococcal serotype surveillance in children with community acquired pneumonia (CAP) or upper respiratory tract infections (URI).

Methods: From March 2021-December 2023, children 3 months to 5 years who presented to the Children's Hospital Colorado Emergency Department with respiratory symptoms were enrolled as CAP or URI; healthy children served as controls. Nasal swabs were tested for pneumococcus by PCR. UAD assays identified pneumococcal serotypes from urine. Groups were compared using descriptive statistics. …

Tet2-Mutant Myeloid Cells Mitigate Alzheimer’S Disease Progression Via Cns Infiltration And Enhanced Phagocytosis In Mice, Katie A Matatall, Trisha K Wathan, Minh Nguyen, Hu Chen, Alexandra Mcdonald, Guantong Qi, Julia A Belk, Marcus A Florez, Duy T Le, Temitope Olarinde, Caitlyn Vlasschaert, Marco M Buttigieg, Chih-Wei Fan, Saul Carcamo, Ruoqiong Cao, Daniel E Kennedy, Arushana A Maknojia, Apoorva Thatavarty, Josaura V Fernandez Sanchez, Hind Bouzid, Surabi Veeraragavan, Susan Crocker, Margaret A Goodell, Antony Rodriguez, Siddhartha Jaiswal, Michael J Rauh, Eirini P Papapetrou, Samuele G Marro, Katherine Y King

Faculty, Staff and Students Publications

Clonal hematopoiesis (CH) is associated with many age-related diseases, but its interaction with Alzheimer's disease (AD) remains unclear. Here, we show that TET2-mutant CH is associated with a 47% reduced risk of late-onset AD (LOAD) in the UK Biobank, whereas other drivers of CH do not confer protection. In a mouse model of AD, transplantation of Tet2-mutant bone marrow reduced cognitive decline and β-amyloid plaque formation, effects not observed with Dnmt3a-mutant marrow. Bone-marrow-derived microglia-like cells were detected at an increased rate in Tet2-mutant marrow recipients, and TET2-mutant human induced pluripotent stem cell (iPSC)-derived microglia were more phagocytic and hyperinflammatory than …

More Than A Ramp: Rethinking School Design For Sensory And Cognitive Inclusion, Andrew Ho

University Honors Theses

This thesis advocates for the integration of the ASPECTSS framework, developed by Magda Mostafa, into legislative standards that would govern the design of educational environments that accommodate students with Autism Spectrum Disorder (ASD). Drawing on evidence from a case study demonstrating significant improvements in student behavior and overall satisfaction through ASPECTSS-based interventions, the thesis highlights the urgent need for these principles to move beyond voluntary adoption and rather, toward enforceable design mandates.

The ASPECTSS framework includes the seven following criterias; Acoustics, Spatial Sequencing, Escape Spaces, Compartmentalization, Transitions, Sensory Zoning, and Safety. This model provides a comprehensive and actionable approach to …

We Who Are Not Cared For: Social Death, The Lie Of Educational Equity, And A Radical Replanting Praxis, Chantell Wesley

University Honors Theses

This thesis examines how the concept of social death, as theorized by Orlando Patterson and expanded by Frank B. Wilderson III and Christina Sharpe, can serve as a transformative foundation for culturally informed care practices within academic institutions. Arguing that traditional equity efforts and even critical race interventions often fall short by focusing on reform within inherently anti-Black systems, I propose a new framework: Radical Replanting Praxis. Using the metaphor of education as a tree, this praxis calls for a shift in attention from reforming institutional "roots" to transforming the "soil"--the relational, ideological, and everyday conditions in which …

Immediate-Use Rescue Medication And The Epilepsy Monitoring Unit: Experiences From An Expert Panel, Evelyn K. Shih, Brin E. Freund, Michael R. Sperling, Danielle A. Becker, Proleta Datta, Sandra Dewar, Edward Faught, Tracy Glauser, R. Edward Hogan, Randa Jarrar, Andres M. Kanner, David King-Stephens, Rebecca E. Matthews, Patricia Penovich, M. Scott Perry, Eric B. Segal, Joseph Sirven, John M. Stern, James W. Wheless, Enrique Carrazana, Adrian L. Rabinowicz, William O. Tatum

Department of Neurology Faculty Papers

BACKGROUND: People with epilepsy (PWE) may experience seizure clusters, broadly defined as ≥2 seizures that occur in close proximity. In epilepsy monitoring units (EMUs), seizure clusters can spontaneously occur during long-term videoelectroencephalogram monitoring (LTVEM) or as a result of antiseizure medication dose adjustments. In this survey, we examined the experiences and practices of expert clinicians with seizure clusters in EMUs.

METHODS: A 55-item survey was sent to members of an Epilepsy Education Council who are epilepsy experts. Items described experiences, treatment practices, and negative outcomes with seizure clusters in EMUs.

RESULTS: Of the 15 experts (aged 43-77 y), 14 are …

Advancing Workforce Development In Digital Health: A Regional Model From The Gcc, Manal Almalki, Osama El-Hassan, Jawad Ahmed, Amr Jamal, Mowafa Househ, Evelyn Hovenga, Paul Barach

College of Population Health Faculty Papers

This study examines the evolution of ZIMAM's role in the Gulf Cooperation Council's (GCC) taskforce on workforce development in digital healthcare. Established in 2016 and formalized as a non-profit organization in 2023, ZIMAM integrates international best practices, regional insights, and innovative strategies to develop a scalable digital health knowledge and skills framework. ZIMAM's methodology includes competency mapping aligned with the Skills Framework for the Information Age (SFIA), stakeholder engagement, and iterative validation to ensure relevance and adaptability. Key ZIMAM initiatives encompass the development of governance structures, capacity-building workshops, annual conferences, and recognition programs such as the ZIMAM-ELSEVIER Digital Health Awards. …

Development Of A Health Knowledge And Skill-Based Framework For The Digital Age, Evelyn Hovenga, Osama El-Hassan, Manal Almalki, Jawad Ahmed, Paul Barach, Mowafa Househ, Amr Jamal

College of Population Health Faculty Papers

The Gulf Cooperation Council (GCC) region is tackling a significant digital healthcare workforce skills gap by creating a computable unified digital health competency framework and repository. Digital technologies and global competency standards are leveraged to professionalize the digital health knowledge domain and facilitate the development of clear career pathways in digital health. A mixed-methods approach was employed to develop the framework. A standardized categorial structure and information model has been developed to support the creation of this computable framework for workforce evaluation and competency-based career development.

Aga Khan University

University press releases and calendars

No abstract provided.

Pakistan: Bringing The Nursing Profession Back To Health

University press releases and calendars

No abstract provided.

Nursing In Pakistan

University press releases and calendars

No abstract provided.

Partnership, Collaboration, And Co-Production To Improve Patient Experience Beyond Conducting Surveys – Lessons From The Quebec Model, Canada, Marie-Pascale Pomey, Catherine Wilhelmy, Myriam Fournier-Tombs, Vincent Dumez, Cécile Vialaron, Monica Nelea Iliescu, Karina Prevost, Simon Courtemanche, Louise Normandin, Geneviève David

Patient Experience Journal

Objective: The objectives of this article are to present how, in the province of Quebec (Canada), healthcare and service partnerships have been implemented, to take stock of the current situation and to suggest ways to continue strengthening the model over the coming years, in Quebec and elsewhere in the world. Methods: Three methods were mobilized: (1) a review of the literature and reports published in recent years on implementations of partnerships in Quebec; (2) a survey sent to the persons responsible for partnerships in Quebec’s health and social services establishments; and (3) a working committee comprised of patient experts, partnership …