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Articles 36541 - 36570 of 1446549
Full-Text Articles in Entire DC Network
The Student Movement Volume 110 Issue 2: Week Of Prayer, Politics, And Purpose, Kara Shepard, Megan Constantine, Corinna Bevier, Melanie Webb, Joey Carrion, Isa Demoraes, Timi Olatunde, Aiko J. Ayala Rios, Ayanda Dewa, Nicoleta Cojan, Madison Vath
The Student Movement Volume 110 Issue 2: Week Of Prayer, Politics, And Purpose, Kara Shepard, Megan Constantine, Corinna Bevier, Melanie Webb, Joey Carrion, Isa Demoraes, Timi Olatunde, Aiko J. Ayala Rios, Ayanda Dewa, Nicoleta Cojan, Madison Vath
The Student Movement V. 110 (2025-2026)
HUMANS
What the Constitution Means to Me, Kara Shepard
Where Passion Meets Purpose: Senior Natalie Reid Reflects on Her College Years, Megan Constantine
ARTS & ENTERTAINMENT
Art Around the City, Corinna Bevier
The Saxophone Reimagined: Cerus Quartet at HPAC, Melanie Webb
The TV Shows That Taught Me Spanish, Corinna Bevier
NEWS
TikTok Survives: Trump Administration Announces Deal to Save the Platform, Joey Carrion
Students Experience "Real Life, real God" at Week of Prayer, Isa DeMoraes
IDEAS
Being Adventist in the 21st Century, Timi Olatunde
Question of the Week #2, Aiko J. Ayala Rios
The Great Spanish Surge, Ayanda Dewa
PULSE …
Controlling Private Economic Power: Lessons Learned From The Us Experience In The First Decades Of The 20th Century, Thierry Kirat, Frédéric Marty
Controlling Private Economic Power: Lessons Learned From The Us Experience In The First Decades Of The 20th Century, Thierry Kirat, Frédéric Marty
Yearbook of Antitrust and Regulatory Studies
Concerns related to Big Techs have led to a proliferation of legislative initiatives to complete competition rules with regulatory devices that would lead gatekeepers to be subject to obligations to preserve an equality of opportunities on the market. Within this context, this contribution revisits American decision-making practice from the end of the 19th century and the beginning of the 20th century to show how regulatory-type interventions and the enforcement of competition rules have been activated to control the strategies of firms acting as gatekeepers. What we can learn from this experience is that a big firm having private regulatory power …
Catholic Jesuit Evangelisation In India: The Successes And Challenges Of Cultural Accommodation And Inculturation, Sajit U. Kabadi
Catholic Jesuit Evangelisation In India: The Successes And Challenges Of Cultural Accommodation And Inculturation, Sajit U. Kabadi
eJournal of Catholic Education in Australasia
Since its inception as a Catholic religious order in 1540, the Society of Jesus continues to be the prominent instrument of Catholic Mission evangelization in the world. There is no bigger example of this than in the country of India. Given that India is a predominantly Hindu nation, Jesuit Catholic evangelization efforts is remarkably successful as well as revealing of complexity. These successful missionary efforts (in terms of number of conversions and Jesuit influence) have not been without its challenges, questions, controversies, and sacrifices of both the Jesuits and the local Indian people. This manuscript presents a historiography of Jesuit …
Rethinking Pain Relief After Surgery: What We Can Learn From Knee Replacements, Asim Trimzi
Rethinking Pain Relief After Surgery: What We Can Learn From Knee Replacements, Asim Trimzi
SKMC Student Presentations and Publications
This paper offers a clear, evidence-based look at how we can reduce opioid use after knee replacement surgery without sacrificing pain relief. This review focuses specifically on total knee arthroplasty (TKA)-one of the most commonly performed and most painful surgeries-and asks whether opioids are truly necessary. By analyzing results from 21 clinical trials, the paper shows that non-opioid medications like NSAIDs and gabapentinoids can provide similar pain control with fewer side effects, such as nausea, dizziness, constipation, and sedation. Lower risk of long-term use is an added benefit. A recent RCT found that after knee/shoulder arthroscopy, 72% of patients in …
Screw Diameter And Healing Outcomes In Jones Fractures: A Scoping Review, Merlin Sajeev, Jessica Sima, Srilalitha Lanka, Amanda Killeen
Screw Diameter And Healing Outcomes In Jones Fractures: A Scoping Review, Merlin Sajeev, Jessica Sima, Srilalitha Lanka, Amanda Killeen
School of Podiatric Medicine - Student Research
Introduction: Jones fractures occur at the metaphyseal–diaphyseal junction of the fifth metatarsal and are prone to delayed or nonunion due to limited perfusion and high mechanical stress. Intramedullary (IM) screw fixation is the standard operative treatment, yielding higher union rates than conservative management. There is no clear consensus on the influence of screw size on healing outcomes.
Aim: To examine the impact of IM screw diameter on union rates in Jones fracture fixation.
Methods: A literature search was conducted using Google Scholar and PubMed with the search term: “"Screw" AND "Diameter" AND "Union" AND "Jones Fractures"”. Articles published between 2015 …
The Beacon, September 26, 2025, Beacon Staff
The Beacon, September 26, 2025, Beacon Staff
The Beacon, 2025-2026
Club Spotlight: Raider Baking Club; North fireplace becomes place of worship; New album marks return of the red-head; “Downton Abbey Finale” overall success; Art and science combine at “Camera Obscura”; Preparation for 2025 music showcase; Surprise animal sightings around campus; Opportunities for college employment; Why the Apocrypha matters; Stop romanticizing all-nighters; NW Cross Country season looks promising; NW Golf places high as the season begins; Alumni Serves as interim e-sports director; The Black Hills: home of humility; The Emmy’s celebrate Hollywood stars
Quality Improvement Project Enhancing Provider Education On Phq-9 Depression Screening To Improve Compliance, Obianuju Okafor
Quality Improvement Project Enhancing Provider Education On Phq-9 Depression Screening To Improve Compliance, Obianuju Okafor
Doctor of Nursing Practice Projects
Depression is a leading cause of disability worldwide; however, screening in primary care remains inconsistent. Even though the Patient Health Questionnaire-9 (PHQ-9) is a validated screening tool, its use is often limited by insufficient provider training. This quality improvement (QI) project aimed to evaluate the impact of structured provider education on PHQ-9 screening practices, with the purpose of improving provider knowledge, confidence, and adherence to screening guidelines in a primary care setting. Guided by Donabedian's Model of Quality Care and Lewin's Change Theory and implemented using the Plan-Do-Study-Act (PDSA) framework, the project used a one-group pre/post design at an outpatient …
Preliminary Petrological, Mineralogical, And Geochemical Evaluation Of A Newly Discovered Lignite Field In Yatağan, Muğla (Sw Türkiye), Işik Hacimustafaoğlu, Mehmet Akbulut, Hülya İnaner, Kimon Christanis
Preliminary Petrological, Mineralogical, And Geochemical Evaluation Of A Newly Discovered Lignite Field In Yatağan, Muğla (Sw Türkiye), Işik Hacimustafaoğlu, Mehmet Akbulut, Hülya İnaner, Kimon Christanis
Turkish Journal of Earth Sciences
Thirty-two coal and seven inorganic core samples from a newly discovered coalfield in the Yatağan region of the Muğla Basin were analysed to reconstruct the depositional palaeoenvironment. The coal has an average bed moisture of 34.60%, an ash yield of 33.73% (db), a volatile matter yield of 57.91% (daf), and a gross calorific value of 12.18 MJ/kg (maf). It is composed of mainly huminite macerals (up to 91 vol.%, on whole-rock basis), predominantly densinite, along small amounts of liptinite and inertinite macerals. The average random reflectance of huminite is 0.28%, and the primary minerals identified include pyrite, quartz, and clay …
Kenyon Collegiate - September 26, 2025
Carbonated High-Al Steel Slag As Supplementary Cementitious Material: Synergy Of Carbonation At Elevated Temperature And Addition Of Gypsum, Nannan Zhang, Gao Deng, Wenyu Liao, Chuanlin Hu, Lingyu Chi, Hongyan Ma
Carbonated High-Al Steel Slag As Supplementary Cementitious Material: Synergy Of Carbonation At Elevated Temperature And Addition Of Gypsum, Nannan Zhang, Gao Deng, Wenyu Liao, Chuanlin Hu, Lingyu Chi, Hongyan Ma
Civil, Architectural and Environmental Engineering Faculty Research & Creative Works
High-Al steel slags, such as ladle metallurgy furnace (LMF) slag, substantially retard the early hydration of cement when incorporated into cement pastes, primarily due to the high mayenite content. In this study, carbonation of slag at elevated temperatures of 60°C and 80°C, combined with gypsum addition, was proposed to synergistically mitigate the retardation effect and enhance the early-age strength of cement pastes. The physical and chemical properties of slags carbonated at various temperatures were analyzed to elucidate their impact on cement performance as a supplementary cementitious material. The results indicate that higher temperatures enhance carbonation reactivity, accelerating the carbonation of …
Common Ground Newsletter Fall 2025, Missouri University Of Science And Technology
Common Ground Newsletter Fall 2025, Missouri University Of Science And Technology
Common Ground
- Internships
- Superb Seniors - Giving
- Standout Student Athletes
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Opportunities And Barriers To Engaging Caregivers In Firearm Suicide Prevention: Findings From Focus Groups With Caregivers Of Veterans., Katherine Macwilliams, John Marmion, Dee Blascyk, Sharon Urbina, Rachel Moyers, Gala True
Opportunities And Barriers To Engaging Caregivers In Firearm Suicide Prevention: Findings From Focus Groups With Caregivers Of Veterans., Katherine Macwilliams, John Marmion, Dee Blascyk, Sharon Urbina, Rachel Moyers, Gala True
School of Medicine Faculty Publications
Background: Firearms are involved in more than 70% of U.S. Veteran suicides. Caregivers, defined as family members or concerned significant others, can play an important role in firearm suicide prevention through initiating conversations about secure firearm storage with Veterans. Our objective was to explore caregivers' experiences with lethal means safety (LMS) conversations and identify perceived barriers to caregivers discussing LMS with healthcare providers and with Veterans. Methods: We conducted focus groups with 32 caregivers with experience caring for a Veteran at risk for suicide. Qualitative data were analyzed using thematic analysis. Results: We identified three primary themes: 1) caregivers recognize …
Effects Of Olfactory Enrichment On Perioperative Neurocognitive Disorders In Elderly Patients Undergoing Orthopedic Surgery: A Study Protocol Of A Multi-Center Randomized Controlled Trial, Xinchun Mei, Jiayi Wang, Zihan Ni, Yanyan Wang, Binglei Zhao, Daniel I Sessler, Zhongcong Xie, Yuan Shen
Effects Of Olfactory Enrichment On Perioperative Neurocognitive Disorders In Elderly Patients Undergoing Orthopedic Surgery: A Study Protocol Of A Multi-Center Randomized Controlled Trial, Xinchun Mei, Jiayi Wang, Zihan Ni, Yanyan Wang, Binglei Zhao, Daniel I Sessler, Zhongcong Xie, Yuan Shen
Faculty, Staff and Student Publications
Background: Neurocognitive disorders are prevalent among older surgical patients, yet their underlying mechanisms and effective interventions remain largely unknown. Studies in rodents and patients suggest a connection between olfactory impairment and perioperative neurocognitive disorder (PND). Previous work in mice demonstrates that anesthesia and surgery can lead to both olfactory impairment and cognitive deficits. Olfactory enrichment, which is also referred to as olfactory training (i.e., daily exposure to multiple odorants), may prove helpful. For example, olfactory enrichment appears to reduce PND-like behaviors in mice, possibly by mitigating anesthesia- and surgery-induced reductions in olfactory receptor neurons. Additionally, olfactory enrichment increases the volume …
Women Clergy Members' Perceptions Of Mentorship Strategies For Leader Development, Linda Ann Brady
Women Clergy Members' Perceptions Of Mentorship Strategies For Leader Development, Linda Ann Brady
Walden Dissertations and Doctoral Studies
According to recent studies, women were underrepresented in senior leadership in the global Christian church, and leadership pathways for the development of women were often lacking. The local problem within the International Christian Church (ICC) was a lack of understanding of holistic mentoring strategies that support the development of women clergy members, which could help fill the current leadership gap. Guided by Dahlvig and Longman’s model of women’s leadership development, the purpose of this basic qualitative study was to explore the perceptions of women clergy regarding holistic mentoring strategies that might increase the number of women in leadership within the …
Native Hawaiian Culturally Appropriate Substance Use Disorders Formative Program Evaluation, Kelly J. Penn
Native Hawaiian Culturally Appropriate Substance Use Disorders Formative Program Evaluation, Kelly J. Penn
Walden Dissertations and Doctoral Studies
Substance use disorders (SUDs) disproportionately affects Native Hawaiians, yet conventional treatments often overlook the cultural, spiritual, and relational foundations of well-being for Native Hawaiians. This gap represents a human services problem, as it perpetuates health disparities, limits recovery, and slows social change within Native Hawaiian communities. The purpose of this qualitative single case study was to identify culturally relevant components for an SUD treatment program tailored to Native Hawaiians. The research question guiding this study was, what are culturally appropriate components for a SUD program for Native Hawaiians. The Nā Pou Kihi framework grounded the exploration of Indigenous approaches to …
The Diamond, September 26, 2025, Dordt University
The Diamond, September 26, 2025, Dordt University
Dordt Diamond
- Front Page: Announcement of Future Construction Brings Mixed Emotions to Campus Community; Dordt Students React to Charlie Kirk's Assassination; Everything and Anything: A Look at the World of Dordt Fizz
- News: An Inside Look at the Atrium: Dining System Changes and Updates; Changes in Academic Calendar Lead to Reduced Finals Week; Gaming Guild Hosts Gaming Guild Olympics Throughout School Year; Retro & Roast Pop-Up; A Turning Point for Revival: Memorial Services Held for Charlie Kirk Across Nation and in Community; Adding Some Pizzazz to Performance Arts Center; Phishing for Trouble
- Feature: Faith, Family, and Farming: Another Fall …
Space: The Final Frontier (For State Power): The History Of The East India Company And The Future Of Outer Space, Richard Culbert
Space: The Final Frontier (For State Power): The History Of The East India Company And The Future Of Outer Space, Richard Culbert
International Law Studies
Outer space may be the last domain where States largely lack the capability to use coercive force as an instrument of State control. In all areas of the globe, major powers have militaries and police forces that far exceed the capability of even the largest corporations. As corporations take an increasingly large role in outer space commerce it is likely that these private actors will develop a capacity to use force that quickly surpasses even the most powerful States.
To date there has been little analysis of this future phenomenon by legal scholars. Perhaps as a result, the current international …
Metaphor Use In Indonesian Scholars' Talk About Migration, Heri Yusup
Metaphor Use In Indonesian Scholars' Talk About Migration, Heri Yusup
Electronic Theses and Dissertations Archive
Despite the growing body of research on the use of metaphors to discuss personal experiences during complex and challenging situations (such as during the COVID-19 pandemic or related to life-threatening illnesses), metaphor analysis is rarely employed to examine how certain individuals use metaphors to talk about their migration experiences. Extensive studies on metaphorical framing of migration have been conducted. However, private discourse is rarely the subject of these studies. Furthermore, metaphor research incorporating conceptual metaphor theory as its theoretical framework seldom underscores the intersection of metaphorical conceptualization and identity construction. Therefore, this dissertation examines the conceptual metaphors used by individuals …
Microstructure Densification In Cement Pastes Enabled By Novel Graphene Types, Sahil Surehali, Taihao Han, Ranjith Divigalpitiya, Aditya Kumar, Narayanan Neithalath
Microstructure Densification In Cement Pastes Enabled By Novel Graphene Types, Sahil Surehali, Taihao Han, Ranjith Divigalpitiya, Aditya Kumar, Narayanan Neithalath
Materials Science and Engineering Faculty Research & Creative Works
The primary barriers hindering graphene's widespread adoption as a performance-enhancing additive in cement-based systems have traditionally been its prohibitive cost and the sustainability concerns associated with conventional manufacturing processes. However, these impediments have recently been mitigated by advancements in detonation synthesis techniques, enabling scalable, cost-effective, and environmentally favorable production of novel graphene types—specifically fractal graphene (FG) and reactive graphene (RG). This paper explores the influence of ultra-low dosages of FG and RG (≤ 0.04 % by mass of cement, which results in ∼20 % increase in compressive strengths) on the pore-structure features of cement pastes. Compared to the control paste, …
Association Between Therapeutic Alliance And Clinical Outcomes In Virtual Telepsychiatry: A Retrospective Analysis Of Data From Talkiatry, Cheryl Person, Nathaniel David Phillips, Kartik Venkatachalam, Georgia Gaveras
Association Between Therapeutic Alliance And Clinical Outcomes In Virtual Telepsychiatry: A Retrospective Analysis Of Data From Talkiatry, Cheryl Person, Nathaniel David Phillips, Kartik Venkatachalam, Georgia Gaveras
Faculty, Staff and Student Publications
Background: Given the increasing demand for accessible mental health services, fully virtual telepsychiatry has become a vital component of modern health care delivery. Therapeutic alliance, the collaborative and affective bond between patients and therapists, is a well-established predictor of clinical outcomes in traditional face-to-face and teletherapy. However, the relationship between therapeutic alliance and clinical outcomes in an outpatient telepsychiatry setting remains less understood.
Objective: Our primary objective was to evaluate the relationship between therapeutic alliance and clinical outcomes for depression and anxiety in an outpatient telepsychiatry practice.
Methods: This retrospective study analyzed data from treatment-seeking adults receiving services from Talkiatry, …
Polymorphism Crystal Structure Prediction With Adaptive Space Group Diversity Control, Sadman Saadeed Omee, Lai Wei, Jianjun Hu
Polymorphism Crystal Structure Prediction With Adaptive Space Group Diversity Control, Sadman Saadeed Omee, Lai Wei, Jianjun Hu
Faculty Publications
Crystalline materials can form different structural arrangements (i.e., polymorphs) with the same chemical composition, exhibiting distinct physical properties depending on how they are synthesized or the conditions under which they operate. For example, carbon can exist as graphite (soft, conductive) or diamond (hard, insulating). Computational methods that can predict these polymorphs are vital in materials science, which help understand stability relationships, guide synthesis efforts, and discover new materials with desired properties without extensive trial-and-error experimentation. However, effective crystal structure prediction (CSP) algorithms for inorganic polymorph structures remain limited. ParetoCSP2 is proposed, a multi-objective genetic algorithm for polymorphism CSP that incorporates …
Pendant Micro-Droplet Evaporation Fabricates Fiber-Optic Mof Gas Sensor In Seconds, Abhishek Prakash Hungund, Bohong Zhang, Narasimman Subramaniyam, Thomas Spudich, Ryan O'Malley, Farhan Mumtaz, Rex E. Gerald, Jie Huang
Pendant Micro-Droplet Evaporation Fabricates Fiber-Optic Mof Gas Sensor In Seconds, Abhishek Prakash Hungund, Bohong Zhang, Narasimman Subramaniyam, Thomas Spudich, Ryan O'Malley, Farhan Mumtaz, Rex E. Gerald, Jie Huang
Electrical and Computer Engineering Faculty Research & Creative Works
The development of photonic-based gas sensors using metal–organic frameworks (MOFs) and other microporous solids is often a multistep, complex process, typically involving MOF synthesis, purification, and attachment of microcrystals to an optical fiber end face. This study introduces a one-step method that integrates MOF synthesis and sensor head fabrication directly onto the fiber end face, forming an extrinsic Fabry–Perot interferometer (EFPI) with a thin film of MOF microcrystals. The resulting film, only 3–10-μm-thick, enhances sensor response by enabling rapid gas detection within seconds. Utilizing a pendant micro-droplet evaporation technique, this method forms a microporous MOF layer in situ, allowing unreacted …
Magnesium Sulfate Attack Of Alite Paste And Mitigation By Surface Carbonation: Monitoring And Comparison Using Novel Portable Fiber-Optic Raman Probe, Bohong Zhang, Gao Deng, Hongyan Ma, Jie Huang
Magnesium Sulfate Attack Of Alite Paste And Mitigation By Surface Carbonation: Monitoring And Comparison Using Novel Portable Fiber-Optic Raman Probe, Bohong Zhang, Gao Deng, Hongyan Ma, Jie Huang
Electrical and Computer Engineering Faculty Research & Creative Works
Sulfate attack on cement matrix is still a "confused world" especially when magnesium sulfate (MgSO4) is the sulfate source. Accurate assessment of sulfate attack is essential for evaluating the structural integrity and durability of concrete in relevant environments. This study presents a portable fiber-optic Raman probe approach with 125 μm spatial resolution, designed for depth-resolved sulfate ingress monitoring in tricalcium silicate (C₃S, Alite) pastes. The probe is also used to evaluate the effectiveness of surface carbonation in mitigating sulfate attack. The results demonstrate a strong correlation between sulfate penetration depth and Raman spectral intensity ratios of sulfate-related vibrational …
Kmt2d Temporally Activates Neuronal Transcriptional Factor Genes To Mediate Cerebellar Granule Cell Differentiation, Shilpa S Dhar, Kyung-Pil Ko, Jinho Jang, Calena Brown-Abel, Tao Lin, Sharad Awasthi, Kaifu Chen, Roy V Sillitoe, Jae-Il Park, Min Gyu Lee
Kmt2d Temporally Activates Neuronal Transcriptional Factor Genes To Mediate Cerebellar Granule Cell Differentiation, Shilpa S Dhar, Kyung-Pil Ko, Jinho Jang, Calena Brown-Abel, Tao Lin, Sharad Awasthi, Kaifu Chen, Roy V Sillitoe, Jae-Il Park, Min Gyu Lee
Duncan NRI Faculty and Staff Publications
Spatiotemporal gene expression is the fundamental feature of cellular differentiation, including neuron differentiation. The epigenetic mechanism underlying spatiotemporal gene regulation during in vivo neuron differentiation remains largely unknown. Granule cells (GCs) constitute the vast majority of neurons in the cerebellum, which contains most of neurons in the brain. Here, we show that
Identifying The Big Questions In Paleontology: A Community-Driven Project, Tracy Aze
Identifying The Big Questions In Paleontology: A Community-Driven Project, Tracy Aze
School of Biological and Marine Sciences
Paleontology provides insights into the history of the planet, from the origins of life billions of years ago to the biotic changes of the Recent. The scope of paleontological research is as vast as it is varied, and the field is constantly evolving. In an effort to identify “Big Questions” in paleontology, experts from around the world came together to build a list of priority questions the field can address in the years ahead. The 89 questions presented herein (grouped within 11 themes) represent contributions from nearly 200 international scientists. These questions touch on common themes including biodiversity drivers and …
Dworf Gene Therapy Improves Cardiac Calcium Handling And Mitochondrial Function, Omar Brito-Estrada, Yasuhide Kuwabara, Aaron M Gibson, Keira R Hassel, Michael L Kamradt, Joseph P Verry, N Scott Blair, Michael J Bround, Jiuzhou Huo, Jeffery D Molkentin, Catherine A Makarewich
Dworf Gene Therapy Improves Cardiac Calcium Handling And Mitochondrial Function, Omar Brito-Estrada, Yasuhide Kuwabara, Aaron M Gibson, Keira R Hassel, Michael L Kamradt, Joseph P Verry, N Scott Blair, Michael J Bround, Jiuzhou Huo, Jeffery D Molkentin, Catherine A Makarewich
Faculty, Staff and Students Publications
Background: Calcium (Ca2+) dysregulation is a hallmark of heart failure, impairing excitation-contraction coupling and contributing to pathological remodeling. The sarco/endoplasmic reticulum Ca2+ ATPase isoform 2a (SERCA2a) mediates Ca2+ reuptake into the sarcoplasmic reticulum (SR) during diastole, but its activity declines in failing hearts. DWORF (dwarf open reading frame), a newly identified cardiac microprotein, enhances SERCA2a activity and improves cardiomyocyte Ca2+ cycling and contractility. SR Ca2+ release also influences mitochondrial metabolism and ATP production. Here, we investigated whether DWORF overexpression improves SR Ca2+ handling, augments mitochondrial Ca2+ signaling, and protects against heart failure progression.
Methods: Transgenic and adeno-associated virus approaches were …
Heart Failure Devices: Treatment Options, Underutilization, And A Proposed Trigger System For Patient Referral And Evaluation, Marat Fudim, Dmitry M Yaranov, Richa Gupta, Laurie Letarte, Samuel F Sears, Brian G Howard, Nir Uriel, Vikram Raje, Kiran Mahmood, Sean P Pinney, Amin Yehya, Amit Alam, Pujan Patel, Albert Hicks, Amarinder Bindra, Steve M Antoine, Jason Feliberti, Allman Rollins, Vishal N Rao, Patrick Mccann, Nirav Raval, Rachel A Garcia, Ahmed Sayed
Heart Failure Devices: Treatment Options, Underutilization, And A Proposed Trigger System For Patient Referral And Evaluation, Marat Fudim, Dmitry M Yaranov, Richa Gupta, Laurie Letarte, Samuel F Sears, Brian G Howard, Nir Uriel, Vikram Raje, Kiran Mahmood, Sean P Pinney, Amin Yehya, Amit Alam, Pujan Patel, Albert Hicks, Amarinder Bindra, Steve M Antoine, Jason Feliberti, Allman Rollins, Vishal N Rao, Patrick Mccann, Nirav Raval, Rachel A Garcia, Ahmed Sayed
Faculty, Staff and Students Publications
The use of guideline-directed medical therapy (GDMT) has substantially prolonged and improved the lives of patients with heart failure (HF). Nevertheless, adherence rates remain suboptimal. Even when successfully maximized and adhered to, there is a substantial residual risk of recurrent HF hospitalization and death. In light of this, there is a strong need for effective interventions that can decrease the high residual risk seen in patients with HF. Several device options exist that are approved by the US Food and Drug Administration and that have been shown to decrease morbidity and/or mortality in patients among whom GDMT is maximized. These …
A Novel Self-Inhaled Nicotine Exposure System In Murine Models Reveals Age-Dependent Metabolic Effects Of Nicotine, Xu Xu, Hailan Liu, Meng Yu, Qingzhuo Liu, Yongxiang Li, Yue Deng, Yuxue Yang, Jingjing Cheng, Yutian Liu, Mengjie Wang, Xing Fang, Longlong Tu, Olivia Z Ginnard, Kristine M Mcdermott, Darah Threat, Fuhui Wang, Meixin Sun, Xinming Liu, Jiamin Qiu, Xi Wu, Jinjing Jian, Tong Zhou, Megan E Burt, Sanika V Jossy, Junying Han, Chunmei Wang, Yongjie Yang, Yong Xu, Yuhan Shi
A Novel Self-Inhaled Nicotine Exposure System In Murine Models Reveals Age-Dependent Metabolic Effects Of Nicotine, Xu Xu, Hailan Liu, Meng Yu, Qingzhuo Liu, Yongxiang Li, Yue Deng, Yuxue Yang, Jingjing Cheng, Yutian Liu, Mengjie Wang, Xing Fang, Longlong Tu, Olivia Z Ginnard, Kristine M Mcdermott, Darah Threat, Fuhui Wang, Meixin Sun, Xinming Liu, Jiamin Qiu, Xi Wu, Jinjing Jian, Tong Zhou, Megan E Burt, Sanika V Jossy, Junying Han, Chunmei Wang, Yongjie Yang, Yong Xu, Yuhan Shi
Faculty, Staff and Students Publications
Background: Nicotine is known to influence metabolism and body weight, yet existing murine models of nicotine exposure often fail to replicate human smoking behaviors accurately. To address this gap, we designed a cost-effective, self-administered nicotine inhalation system that allows mice to voluntarily inhale nicotine vapor generated from e-liquid.
Results: Using this system, we investigated the metabolic effects of nicotine exposure in adult and adolescent mice. Adult mice exposed to nicotine vapor for 10 days exhibited significant weight loss, which was rapidly regained upon cessation, paralleling human smoking patterns. In contrast, adolescent mice did not lose weight during nicotine exposure but …
Distinct Intrinsic And Extrinsic Factors Differentially Regulate Skeletal Stem Cells In Calvaria Versus Long Bones During Bone Regeneration, Jea Solidum, Kohei Yamasaki, Youngjae Jeong, Laura Ortinau, Francisco Heralde, Dongsu Park
Distinct Intrinsic And Extrinsic Factors Differentially Regulate Skeletal Stem Cells In Calvaria Versus Long Bones During Bone Regeneration, Jea Solidum, Kohei Yamasaki, Youngjae Jeong, Laura Ortinau, Francisco Heralde, Dongsu Park
Faculty, Staff and Students Publications
Calvarial suture skeletal stem cells (Su-SSCs) are a distinct stem cell population for craniofacial bone formation by intramembranous ossification, compared to long bone periosteal SSCs (LB-PSSCs) with endochondral (osteochondrogenic) ossification. However, whether SSC intrinsic or extrinsic factors affect their differentiation process has not been well elucidated. Here, using an inducible Prx1-CreER-EGFP+/−;Rosa26-tdTomato mouse model, we observed that endogenous Prx1+ Su-SSCs and their orthotopic transplantation into calvarial injury do not form cartilage intermediates at the injury sites, while the transplantation of Prx1+ LB-PSSCs into LB injury induces osteochondrogenic differentiation, respectively. However, the heterotopic transplantation of Prx1+ Su-SSCs (Su-SSCs …