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Articles 32641 - 32670 of 1439293
Full-Text Articles in Entire DC Network
Strange And Weird Tales: H.P. Lovecraft And Horror In American History, Serafin Hector Matthews
Strange And Weird Tales: H.P. Lovecraft And Horror In American History, Serafin Hector Matthews
Doctoral Dissertations and Projects
Author Howard Phillips (H.P.) Lovecraft (1890-1937) of Rhode Island was a transformative figure in American fiction. Hailed by one modern writer as “the twentieth-century horror story’s dark and baroque prince,” Lovecraft wrote over sixty-five works of fiction representing—alongside Clark Ashton Smith, Robert Bloch, and David H. Keller—“the golden age of weird fiction.” Lovecraft, however, enjoyed only modest commercial success during his lifetime, writing for amateur journals and pulp magazines such as The Vagrant, Amazing Stories, and Weird Tales. Most of his stories, then, were not published in hardcover or paperback form until after his death, including what many literary critics …
Generation Z And The Church: A Phenomenological Study Of Perceptions, Barriers, And Opportunities For Church Engagement, Hector Albert Soto
Generation Z And The Church: A Phenomenological Study Of Perceptions, Barriers, And Opportunities For Church Engagement, Hector Albert Soto
Doctoral Dissertations and Projects
The purpose of this phenomenological study was to examine the perceptions, barriers, and opportunities that shape the relationship between Generation Z and the Christian church, with particular attention to how these factors influence patterns of engagement. Recent trends indicated a significant decline in church engagement among Generation Z, contributing to the erosion of vital resources necessary for the sustained vitality of contemporary Christian congregations (Barna, 2020; Braddy, 2021; Earls, 2020). The study was guided by three research questions: 1) What Generation Z variables did the church need to focus on to attract and retain Gen Z (e.g., social concerns, leadership …
1-2-1 Reciprocal Discipleship: A Transformation Strategy For Effectively Growing Mature Disciples Of Jesus Christ, Scott M. Whitley
1-2-1 Reciprocal Discipleship: A Transformation Strategy For Effectively Growing Mature Disciples Of Jesus Christ, Scott M. Whitley
Doctoral Dissertations and Projects
Believers in the Lord Jesus Christ are called to be transformed into the image of Christ through the intimacy of knowing the Father (Eph. 4:13; 2 Cor. 3:18; John 17:3). This can be taught and experienced through one-on-one discipleship, thus fulfilling the Great Commission. Unfortunately, many different discipleship models have become the prevailing stratagem, leaving one-on-one discipleship less emphasized or wholly abandoned. This has resulted in significant transformation through intimacy being lost in many churches and leading to a departure from scriptural discipleship. Therefore, this action research project assumed that consistent participation in the 1-2-1 Reciprocal Discipleship: A Transformation Strategy …
An Intellectual History Of The American Right To Keep And Bear Arms, John Charles Davis
An Intellectual History Of The American Right To Keep And Bear Arms, John Charles Davis
Doctoral Dissertations and Projects
This dissertation presents an examination of the intellectual history of the American right to keep and bear arms, as well as its embodiment in the Second Amendment of the United States Constitution. The document presents the history of ideas surrounding the concept of the right to keep and bear arms, from early Western Civilization through various channels, including English traditions, and how they contributed to the unique perspective on the right to keep and bear arms that emerged in America. Explores not only English contributions, but those of the Scots, and philosophers throughout Europe and Western Civilization, as well as …
Building Stability Through Compassion: A Study Of City Gates Ministries’ Impact On Homelessness And Resource Distribution, Bryan Christopher Pruitt
Building Stability Through Compassion: A Study Of City Gates Ministries’ Impact On Homelessness And Resource Distribution, Bryan Christopher Pruitt
Doctoral Dissertations and Projects
This Dissertation-in-Praxis focused on how City Gates Ministries, a nonprofit organization in Thurston County, Washington, improved its support for individuals and families facing homelessness and poverty by refining its operational systems. The initiative aimed to strengthen donation intake, inventory management, and furniture delivery, which had previously strained resources and hindered organizational consistency. Guided by biblical leadership principles, the project introduced cost-effective solutions like a barcode-based digital inventory system, color-coded signage, and modular volunteer training sessions. Outcomes included a 30% reduction in inventory duplication errors, a nearly 45% decrease in retrieval times for high-demand items, and a decrease in misplaced inventory …
The Effects Of Personalized Learning On High School English Language Arts Students' Self-Perceived College And Career Readiness: A Phenomenological Study, Erica Hyneman
Doctoral Dissertations and Projects
The purpose of this phenomenological study was to discover the lived experiences of personalized learning when implemented in a high school English language arts class for students at County High School. The theory guiding this study was constructivist learning theory, as it is the foundation for personalized learning. The central research question aimed to discover the lived experiences of personalized learning in a high school English language arts classroom. This transcendental phenomenological study included 12 participants enrolled in an 11th-grade English language arts class at County High School, a rural, public, Title I school in the deep south. Data was …
"Concealed Sorrow": Unveiling The Implications Of Miscarriages On Women In England 1500-1600s, Krista Ann Everson
"Concealed Sorrow": Unveiling The Implications Of Miscarriages On Women In England 1500-1600s, Krista Ann Everson
Doctoral Dissertations and Projects
This study examines the societal, religious, and political implications of miscarriage in Tudor England, with a particular focus on the experiences of Anne Boleyn. Miscarriage, a profoundly personal yet historically stigmatized event, intersects with broader cultural, theological, and economic forces that shape public and private responses to it. By exploring Anne Boleyn’s miscarriages within the context of Tudor society, this research sheds light on how historical understandings of pregnancy loss have influenced cultural attitudes and policies, offering insights into the lived realities of women in the early modern period.
Influence Of High-Speed Internet Infrastructure Availability On Aggregate Academic Outcome Measures For Washington State High Schools, Jessie A. Tanksley
Influence Of High-Speed Internet Infrastructure Availability On Aggregate Academic Outcome Measures For Washington State High Schools, Jessie A. Tanksley
Walden Dissertations and Doctoral Studies
Limited research has been conducted about the potential influence of high-speed broadband infrastructure availability in rural and urban communities on high school academic outcome measures in Washington state. Guided by Siemens’s theory of connectivism and van Dijk’s digital divide theory, the purpose of this quasi-experimental, causal-comparative, quantitative study was to determine whether significant differences in high school academic performance, measured by graduation rates and standardized test scores, exist between urban and rural communities with and without access to high-speed broadband internet infrastructure in Washington state. Three research questions were developed to examine differences in graduation rates, 10th-grade English Language Arts …
Strategies For Recruitment And Retention Of Mental Health Providers In The Military Health System, Christopher J. Chase
Strategies For Recruitment And Retention Of Mental Health Providers In The Military Health System, Christopher J. Chase
Walden Dissertations and Doctoral Studies
Recruitment and retention of mental health professionals are critical challenges for the Military Health System (MHS), affecting timely access to behavioral health care, workforce stability, and mission readiness. Persistent shortages threaten the well-being of service members and increase reliance on the resilience of overburdened staff, particularly in rural and underserved areas. This integrative review aimed to identify and synthesize best practices to improve recruitment and retention of mental health providers within the MHS. Using the Johns Hopkins Nursing Evidence-Based Practice Model, a systematic literature search and thematic analysis were conducted on 27 high-quality research and non-research articles. The Affective, Continuance, …
Protocol For Isolating Patient-Derived Ascites Cells And Extracellular Vesicles From Gastric Cancer Peritoneal Metastases, Yibo Fan, Jody V Vykoukal, Shumei Song, Melissa Pool Pizzi, Gengyi Zou, Katsuhiro Yoshimura, Jiankang Jin, Hiroyuki Katayama, George A Calin, Rebecca E Waters, Qiong Gan, Linghua Wang, Samir Hanash, Shilpa S Dhar, Jaffer A Ajani
Protocol For Isolating Patient-Derived Ascites Cells And Extracellular Vesicles From Gastric Cancer Peritoneal Metastases, Yibo Fan, Jody V Vykoukal, Shumei Song, Melissa Pool Pizzi, Gengyi Zou, Katsuhiro Yoshimura, Jiankang Jin, Hiroyuki Katayama, George A Calin, Rebecca E Waters, Qiong Gan, Linghua Wang, Samir Hanash, Shilpa S Dhar, Jaffer A Ajani
Faculty, Staff and Student Publications
Peritoneal carcinomatosis (PC) cells and extracellular vesicles (EVs) from gastric cancer ascites are valuable for studying tumor-stroma interactions. Here, we present a protocol for isolating PC cells and EVs from patient ascites. We describe steps for PC cell culture, iodixanol-based EV purification, electron microscopy, nanoparticle tracking analysis, flow cytometry, and proteomic profiling. This protocol also includes TD-139 loading into exosomes for functional assays to evaluate their role in modulating the tumor microenvironment. For complete details on the use and execution of this protocol, please refer to Fan et al.
Equal Survival For Black Americans With Multiple Myeloma When Appropriately Matched To White Americans, David E Mery, Guido Tricot, Samer Al Hadidi, Yihao Zhan, Cody Ashby, Clyde Bailey, Eric R Siegel, Daisy V Alapat, Hongwei Xu, Sandra Mattox, Caroline Schinke, Maurizio Zangari, Sharmilan Thanendrarajan, Qing Yi, Robert Z Orlowski, Frits Van Rhee, John D Shaughnessy, Fenghuang Zhan
Equal Survival For Black Americans With Multiple Myeloma When Appropriately Matched To White Americans, David E Mery, Guido Tricot, Samer Al Hadidi, Yihao Zhan, Cody Ashby, Clyde Bailey, Eric R Siegel, Daisy V Alapat, Hongwei Xu, Sandra Mattox, Caroline Schinke, Maurizio Zangari, Sharmilan Thanendrarajan, Qing Yi, Robert Z Orlowski, Frits Van Rhee, John D Shaughnessy, Fenghuang Zhan
Faculty, Staff and Student Publications
No abstract provided.
Cover And Contents
Turkish Journal of Veterinary & Animal Sciences
No abstract provided.
Additive Mindfulness: A Systematic Review And Thematic Analysis, Whitney M. Crawford
Additive Mindfulness: A Systematic Review And Thematic Analysis, Whitney M. Crawford
Doctoral Dissertations and Projects
Mindfulness is a state of present moment-focused non-judgmental awareness, the purposeful practice of which has been shown to promote psychological well-being by alleviating past-oriented rumination, future-focused worry, and experiential avoidance. Because the most widely adopted mindfulness-based interventions (MBIs) were developed based on Buddhist meditation practices, there have also been developed various religiously modified iterations of mindfulness–especially those tailored to Christian clients who are wary of engaging with Buddhist-derived practices. While secular and Buddhist MBIs promote non-judgmental awareness for the sake of mere nonattachment to external and internal experiences, Christian mindfulness promotes detachment from these things in order that one may …
Qualitative Ethnographic Research On The Efficacy Of A Christian-Based Approach To Mentorship For Black Males, Arnold M. Campbell
Qualitative Ethnographic Research On The Efficacy Of A Christian-Based Approach To Mentorship For Black Males, Arnold M. Campbell
Doctoral Dissertations and Projects
This study advanced qualitative research by identifying several statistical gaps in the social sciences related to leadership development, learning principles, character traits, and spiritual formation for a specific demographic of Black males. This researcher aimed to understand the efficacy of Christian-based actions through mentorship programs that intend to address social deficits. From a theological and theoretical context, this research literature review and observations focused on the practical Christian-based approaches to mentorship that provided a model to improve the lives of a specific demographic of Black males considered high-risk and vulnerable. The target group was raised in single-parent homes and attended …
Pilot Study: Integrating The Epic Stroke Narrator Into Inpatient Code Stroke Protocols To Improve Symptom Onset Identification And Reduce Intervention Times, Stacy L. Carter
Doctoral Dissertations and Projects
In-hospital strokes are often underrecognized, leading to treatment delays and poorer outcomes compared to community-onset strokes. This scholarly project evaluated whether integrating the Epic Stroke Narrator into inpatient code stroke protocols could improve documentation of last known well time (LKWT) and reduce time to intervention. A 6-week quasi-experimental pilot study guided by the Iowa Model of Evidence-Based Practice and Rogers’ diffusion of innovations theory was conducted on a neuroscience telemetry step-down unit at a comprehensive stroke center in Richmond, Virginia. Education on the Stroke Narrator was provided to bedside nurses and was followed by implementation and evaluation of narrator use …
The Lived Experiences And Perspectives Of Higher Education Faculty Regarding The Use Of Artificial Intelligence Writing Tools On Students' Coursework: A Phenomenological Study, Kalary T. Driggers
The Lived Experiences And Perspectives Of Higher Education Faculty Regarding The Use Of Artificial Intelligence Writing Tools On Students' Coursework: A Phenomenological Study, Kalary T. Driggers
Doctoral Dissertations and Projects
The purpose of this transcendental phenomenological study was to understand the lived experiences and perspectives of higher education faculty in the Southeastern United States on student use of artificial intelligence writing tools in their coursework. The theory guiding this study was Rogers’ diffusion of innovations, which considers the acceptance of innovations over time. The central research question for this study was, “What are the lived experiences and perspectives of higher education faculty regarding the use of artificial intelligence writing tools on student coursework in higher education?” This study employed a transcendental phenomenological approach, as the researcher sought to understand the …
Public Administrators’ Role In Law Enforcement Training: How Public Administrators Influence The Communication Gap Between Law Enforcement Personnel And Society, Lori B. Singer-Bare
Public Administrators’ Role In Law Enforcement Training: How Public Administrators Influence The Communication Gap Between Law Enforcement Personnel And Society, Lori B. Singer-Bare
Doctoral Dissertations and Projects
Communication training in police academies has historically been lacking across the nation. Prior research indicates that communication skills are necessary for law enforcement professionals. Recent incidents have indicated that a communication gap occurs between law enforcement professionals and community members. Ultimately, public administrators play a role in the delivery of law enforcement services. In Ohio, the 2024 Blue Ribbon Task Force uncovered that communication training for law enforcement professionals is lacking. Public administrators are often charged with making proposals for organizational and law enforcement training to address societal needs. State Attorney Generals often oversee the Peace/Police Officer Training Academy and …
A Phenomenological Study Of Parent And Educator Perceptions Of Inclusive Education For Individuals With Disabilities, Karin Elizabeth Kawagoe
A Phenomenological Study Of Parent And Educator Perceptions Of Inclusive Education For Individuals With Disabilities, Karin Elizabeth Kawagoe
Doctoral Dissertations and Projects
This phenomenological qualitative study, grounded in disability theory, explores the lived experiences of parents and educators regarding inclusive education. At present, laws and regulations promote the inclusion of individuals with disabilities. Inclusion has evolved since the mid-1950s. The biblical foundation for inclusion draws on the life of Jesus. This study examined how concepts of belonging, willingness, perceptions of inclusion, and evidenced based practices manifest in perceptions of advocacy, empathy, flexibility, and collaboration. Data was collected using interviews with parents and educators. Thematic analysis revealed that parents’ experiences centered on advocacy, resilience, empathy, and compassion, reflecting feelings of isolation and being …
A Case Study Of Ai-Enabled Software As A Medical Device Cleared By The Fda For Assessing Hemorrhage Risk Index (Appraise-Hri) After Trauma, Andrew Frock, Jeffrey T Robbins, Francisco G Vital-Lopez, Valmik Desai, Gheorghe Doros, Barry E Sands, Arunkumar Prabhakaran, Christopher Nemeth, Gregory T Rule, Jason L Sperry, Francis X Guyette, Stephen R Wisniewski, Ernest E Moore, Martin Schreiber, Bellal Joseph, Chad T Wilson, Bryan Cotton, Daniel Ostermayer, Brian G Harbrecht, Mayur B Patel, Suzanne Tamang, Sanjay Malunjkar, David A Spain, Andrew T Reisner, Jonathan D Stallings, Jaques Reifman
A Case Study Of Ai-Enabled Software As A Medical Device Cleared By The Fda For Assessing Hemorrhage Risk Index (Appraise-Hri) After Trauma, Andrew Frock, Jeffrey T Robbins, Francisco G Vital-Lopez, Valmik Desai, Gheorghe Doros, Barry E Sands, Arunkumar Prabhakaran, Christopher Nemeth, Gregory T Rule, Jason L Sperry, Francis X Guyette, Stephen R Wisniewski, Ernest E Moore, Martin Schreiber, Bellal Joseph, Chad T Wilson, Bryan Cotton, Daniel Ostermayer, Brian G Harbrecht, Mayur B Patel, Suzanne Tamang, Sanjay Malunjkar, David A Spain, Andrew T Reisner, Jonathan D Stallings, Jaques Reifman
Faculty, Staff and Student Publications
Hemorrhage is the leading cause of preventable death on the battlefield, yet combat medics lack clinical decision support systems to help stratify hemorrhage risk in trauma casualties. We previously trained the Automated Processing of the Physiological Registry for Assessment of Injury Severity - Hemorrhage Risk Index (APPRAISE-HRI) software to associate patterns in vital signs (heart rate and blood pressure) collected from trauma patients with three HRI levels: I (low), II (average), or III (high). To independently validate APPRAISE-HRI and obtain U.S. Food and Drug Administration (FDA) clearance, we collected trauma registry and continuous vital sign data from 5895 trauma patients …
Vista: October 16, 2025, University Of San Diego
Vista: October 16, 2025, University Of San Diego
USD Vista (1965-)
No abstract provided.
Kenyon Collegian - October 16, 2025
Invited But Not Welcome: Assimilation, Emotional Labor, And The Limits Of Belonging For Middle-Class Haitians, Jodie Boisvert
Invited But Not Welcome: Assimilation, Emotional Labor, And The Limits Of Belonging For Middle-Class Haitians, Jodie Boisvert
Electronic Theses and Dissertations 2020 - Present
The problem of the 21st century is not simply that of the “color line,” but rather of how diverse groups of Blacks (Americans and immigrants alike) experience the “color line.” This interview-based dissertation project addresses this problem by examining how thirty-eight first-, 1.5-, and second-generation middle-class Haitian immigrants engage with and reconcile the color line in their lives. This dissertation finds that these immigrants “performatively assimilate” to access privileged middle- and upper-class spaces. Through strategies of strategic ethnicity, code switching, and signifying Haitian exceptionalism, they are able to achieve stable and fulfilling careers and financial security. This dissertation proposes a …
A Pooled Sample Study Of Opioid Use Disorder Treatment Wait Time Among A Pregnant Population In New York, Stanley Nkemjika, Gulshan Begum, Bolaji Yoade, Vaibhav Vyas, Henry Onyeaka, Olubusola Olatunji, Olaniyi Olayinka, Ayana Jordan
A Pooled Sample Study Of Opioid Use Disorder Treatment Wait Time Among A Pregnant Population In New York, Stanley Nkemjika, Gulshan Begum, Bolaji Yoade, Vaibhav Vyas, Henry Onyeaka, Olubusola Olatunji, Olaniyi Olayinka, Ayana Jordan
Faculty, Staff and Student Publications
Background and Aim: Opioid use disorder (OUD) during pregnancy has become a major public health issue, with its prevalence rising significantly in recent years. The incidence of neonatal abstinence syndrome (NAS) has also surged, from 1.5 cases per 1000 hospital births in 1999 to 6.0 cases per 1000 in 2013. This study aims to identify and analyze the concerns faced by pregnant people in accessing OUD treatment on time, specifically focusing on New York.
Methods: The pooled sample of 225,275 individuals represents pregnant patients with OUD who received treatment at substance use disorder (SUD) facilities across New York State between …
Addressing Language Challenges In Bilingual Neuropsychological Assessments At The South Texas Alzheimer's Disease Research Center (Adrc), Stephanie Santiago-Mejias, Gabrielle Hromas, Ashley Laroche, David A. Gonzalez, Robin C. Hilsabeck, Katya Rascovsky, Silvia Mejia-Arango, Amy Werry-Mcfarlin, Claudia Satizabal, Hector Trevino
Addressing Language Challenges In Bilingual Neuropsychological Assessments At The South Texas Alzheimer's Disease Research Center (Adrc), Stephanie Santiago-Mejias, Gabrielle Hromas, Ashley Laroche, David A. Gonzalez, Robin C. Hilsabeck, Katya Rascovsky, Silvia Mejia-Arango, Amy Werry-Mcfarlin, Claudia Satizabal, Hector Trevino
School of Medicine Publications
Introduction: Neuropsychological assessment of bilingual (English/Spanish) individuals presents challenges that can impact test validity. Language proficiency influences cognitive performance, yet clear guidelines for determining the appropriate test language are lacking. We describe our experiences at the South Texas Alzheimer's Disease Research Center (STAC) in addressing these challenges within the context of National Alzheimer's Coordinating Center (NACC) Uniform Data Set (UDS) assessments and broader Alzheimer's Disease Research Center (ADRC) protocols. We outline steps toward a structured language assessment approach.
Methods: We implemented a process to assess language proficiency, integrating self-reported and objective measures, including the language dominance index (LDI). Case examples …
Collisional Excitation Of Hcn By Co To Refine The Modeling Of Cometary Comae, Francesca Tonolo, Ernesto Quintas-Sánchez, Adrian Batista-Planas, Richard Dawes, François Lique
Collisional Excitation Of Hcn By Co To Refine The Modeling Of Cometary Comae, Francesca Tonolo, Ernesto Quintas-Sánchez, Adrian Batista-Planas, Richard Dawes, François Lique
Chemistry Faculty Research & Creative Works
We present the first dataset of collisional (de)-excitation rate coefficients of HCN induced by CO, one of the main perturbing gases in cometary atmospheres. The dataset spans the temperature range of 5–50 K. It includes both state-to-state rate coefficients involving the lowest ten and nine rotational levels of HCN and CO, respectively, and the so-called "thermalized" rate coefficients over the rotational population of CO at each kinetic temperature. The derivation of these coefficients exploited the good performance of the statistical adiabatic channel model (SACM) on top of an accurate interaction potential computed at the CCSD(T)-F12b/CBS level of theory. The reliability …
Dietary Patterns For Weight And Glycemic Management In Persons With Type 1 Diabetes: A Meta-Analysis Of Clinical Trials, Daria Igudesman, Laura M Nally, Alyssa A Grimshaw, Craig G Gunderson, Elizabeth G Considine, Laura M Jacobsen, Mustafa Tosur, Peter A Gottlieb, Irl B Hirsch, Lori M Laffel, Jennifer L Sherr, Chantal Mathieu, Richard E Pratley
Dietary Patterns For Weight And Glycemic Management In Persons With Type 1 Diabetes: A Meta-Analysis Of Clinical Trials, Daria Igudesman, Laura M Nally, Alyssa A Grimshaw, Craig G Gunderson, Elizabeth G Considine, Laura M Jacobsen, Mustafa Tosur, Peter A Gottlieb, Irl B Hirsch, Lori M Laffel, Jennifer L Sherr, Chantal Mathieu, Richard E Pratley
Children’s Nutrition Research Center Staff Publications
Background: Medical nutrition therapy is fundamental for managing glycemia and weight in type 1 diabetes, yet dietary guidance specific to this population and relevant subgroups is lacking.
Purpose: We synthesized the interventional literature investigating diet patterns for glycemic and weight management in youth and adults with type 1 diabetes, with attention to interindividual variation that suggests the need for precision approaches. The protocol was prospectively registered (CRD42024519941).
Data sources: AMED, CINAHL, Cochrane Library, Ovid MEDLINE, Ovid Embase, Google Scholar, and Web of Science Core Collection were searched from January 2011 to June 2024.
Study selection: Clinical trials ≥4 weeks with …
Empowering Psychiatric Nurse Practitioners To Address Nutritional Deficits: An Educational Quality Improvement Study, Beatrice Joan Richards
Empowering Psychiatric Nurse Practitioners To Address Nutritional Deficits: An Educational Quality Improvement Study, Beatrice Joan Richards
Doctoral Dissertations and Projects
Psychiatry is a complex and multifaceted discipline, and treatment approaches often vary based on provider preference and philosophy. Some focus heavily on pharmacotherapies, while others use psychotherapeutic methods, and still others take a more holistic approach involving full-body wellness. All three strategies are beneficial, and providing psychiatric care with a combination of them all can address the full spectrum of factors that influence one’s mental health. Much research, education, and clinical focus have been put on pharmacotherapy and psychotherapeutics. However, there is a marked lack of understanding regarding the holistic realm of psychiatric care, specifically the role of nutrition, amongst …
Therapy Dogs As A Catalyst To Physical Exercise And The Effect On Transgender Adolescents’ Mental Health, Tatiana Sokolik
Therapy Dogs As A Catalyst To Physical Exercise And The Effect On Transgender Adolescents’ Mental Health, Tatiana Sokolik
Doctorate in Kinesiology
This dissertation examines the effects of therapy dog interactions on physical activity levels and mental health outcomes among transgender adolescents. Using a quasi-experimental mixed- methods design, participants engaged in three weekly sessions with a certified therapy dog, with data collected through validated measures of anxiety, depression, affect, and physical activity, supplemented by qualitative feedback. Quantitative results indicated no significant increases in physical activity, though participants reported feeling motivated to spend more time outdoors. Notably, negative affect decreased significantly post-intervention, suggesting short-term emotional benefits. Qualitative findings further highlighted enhanced mood, self-awareness, and coping strategies. While improvements in anxiety and depression were …
Two Commonly Reported Incidental Variants In Otc Are Associated With Late-Onset Disease, Steven H Lang, Russell S Lo, Gareth A Cromie, Aimée M Dudley, Nicholas Ah Mew, Kara Simpson, Vernon Reid Sutton, Sandra Darilek, Saima Ali, Matthew T Snyder, Brendan Lee, Ronit Marom, Sandesh C S Nagamani, Lindsay C Burrage
Two Commonly Reported Incidental Variants In Otc Are Associated With Late-Onset Disease, Steven H Lang, Russell S Lo, Gareth A Cromie, Aimée M Dudley, Nicholas Ah Mew, Kara Simpson, Vernon Reid Sutton, Sandra Darilek, Saima Ali, Matthew T Snyder, Brendan Lee, Ronit Marom, Sandesh C S Nagamani, Lindsay C Burrage
Faculty, Staff and Students Publications
Asymptomatic individuals with pathogenic variants in OTC, the gene encoding ornithine transcarbamylase are increasingly being identified through cascade testing, carrier screening, or as secondary findings from genome-wide sequencing tests. However, guidance for counseling and management of such individuals is currently lacking. We selected two common OTC variants for phenotypic and functional characterization: NM_000531.6:c.118C>T p.(Arg40Cys) and NM_000531.6:c.1061T>G p.(Phe354Cys). The former is the most frequently reported pathogenic/likely pathogenic missense variant present in gnomAD, and the latter has been frequently encountered in our clinical practice. We performed a retrospective chart review at our center, queried the database of the Urea Cycle …
Genetic Determinants And Genomic Consequences Of Non-Leukemogenic Somatic Point Mutations, Joshua S Weinstock, Sharjeel A Chaudhry, Maria Ioannou, Maria Viskadourou, Paula Reventun, Yasminka A Jakubek, L Alexander Liggett, Cecelia Laurie, Jai G Broome, Alyna Khan, Kent D Taylor, Xiuqing Guo, Patricia A Peyser, Eric Boerwinkle, Nathalie Chami, Eimear E Kenny, Ruth J Loos, Bruce M Psaty, Russell P Tracy, Jennifer A Brody, Jeong H Yun, Michael H Cho, Ramachandran S Vasan, Sharon L Kardia, Jennifer A Smith, Laura M Raffield, Aurelian Bidulescu, Emily C O'Brien, Mariza De Andrade, Jerome I Rotter, Stephen S Rich, Russell P Tracy, Yii Der Ida Chen, C Charles Gu, Chao A Hsiung, Charles Kooperberg, Bernhard Haring, Rami Nassir, Rasika Mathias, Alex Reiner, Vijay G Sankaran, Charles J Lowenstein, Thomas W Blackwell, Goncalo R Abecasis, Albert V Smith, Hyun M Kang, Pradeep Natarajan, Siddhartha Jaiswal, Alexander Bick, Wendy S Post, Paul Scheet, Paul Auer, Theodoros Karantanos, Alexis Battle, Marios Arvanitis
Genetic Determinants And Genomic Consequences Of Non-Leukemogenic Somatic Point Mutations, Joshua S Weinstock, Sharjeel A Chaudhry, Maria Ioannou, Maria Viskadourou, Paula Reventun, Yasminka A Jakubek, L Alexander Liggett, Cecelia Laurie, Jai G Broome, Alyna Khan, Kent D Taylor, Xiuqing Guo, Patricia A Peyser, Eric Boerwinkle, Nathalie Chami, Eimear E Kenny, Ruth J Loos, Bruce M Psaty, Russell P Tracy, Jennifer A Brody, Jeong H Yun, Michael H Cho, Ramachandran S Vasan, Sharon L Kardia, Jennifer A Smith, Laura M Raffield, Aurelian Bidulescu, Emily C O'Brien, Mariza De Andrade, Jerome I Rotter, Stephen S Rich, Russell P Tracy, Yii Der Ida Chen, C Charles Gu, Chao A Hsiung, Charles Kooperberg, Bernhard Haring, Rami Nassir, Rasika Mathias, Alex Reiner, Vijay G Sankaran, Charles J Lowenstein, Thomas W Blackwell, Goncalo R Abecasis, Albert V Smith, Hyun M Kang, Pradeep Natarajan, Siddhartha Jaiswal, Alexander Bick, Wendy S Post, Paul Scheet, Paul Auer, Theodoros Karantanos, Alexis Battle, Marios Arvanitis
Faculty, Staff and Students Publications
Clonal hematopoiesis (CH) is defined by the expansion of a lineage of genetically identical cells in blood. Genetic lesions that confer a fitness advantage, such as leukemogenic point mutations or mosaic chromosomal alterations (mCAs), are frequent mediators of CH. However, recent analyses of both single cell-derived colonies of hematopoietic cells and population sequencing cohorts have revealed CH frequently occurs in the absence of known driver genetic lesions. To characterize CH without known driver genetic lesions, we use 51,399 deeply sequenced whole genomes from the NHLBI TOPMed sequencing initiative to perform simultaneous germline and somatic mutation analyses among individuals without leukemogenic …