Digital Commons Network^™

Therapeutic Radiation Drives Leptomeningeal Dissemination Of Medulloblastoma Through An Innate Immune Process, Carolina Nör, Kaitlin Kharas, Alex Rasnitsyn, Maria C Vladoiu, Nam Woo Cho, Jacob S Young, Felipe Nör, Ncedile Mankahla, Joonas Haapasalo, Kristiina Nordfors, Sara Rapic, Patryk Skowron, Raúl A Suárez, Alexander T Bahcheli, Oliver Ocsenas, Xin Chen, Shahrzad Bahrampour, Ali Momin, Lakshmikirupa Sundaresan, Winnie Ong, Liam D Hendrikse, Namal Abeysundara, Kyle Juraschka, Michelle Ly, Jonelle G Pallota, Tajana Douglas, Ning Huang, Hao Wang, Esta Mak, Lei Qin, Jessica Liu, Lily Shen, Betty Luu, Alex Manno, Sachin A Kumar, Laura K Donovan, Vernon Fong, Cory Richman, Craig Daniels, Livia Garzia, Jeremy N Rich, Cynthia Hawkins, Xiaochong Wu, Ralph Dacosta, Jüri Reimand, Xi Huang, Vijay Ramaswamy, David R Raleigh, Michael D Taylor

Faculty, Staff and Students Publications

Leptomeningeal metastases are the most important source of morbidity and mortality for medulloblastoma patients. Radiation of the entire brain is highly effective in the treatment and/or prevention of medulloblastoma leptomeningeal metastases. Infants treated on clinical trials with focal tumor radiation recur metastatically, whereas infants treated with only chemotherapy relapse locally. In murine medulloblastoma model systems, provision of a single dose of radiation to the tumor drives leptomeningeal dissemination. An inflammatory response after radiation-induced tumor cell death recruits a variety of immune cells. Inflammation opens the local blood-brain barrier, allowing intravasation of medulloblastoma cells. Experimental induction of inflammation with lipopolysaccharide drives …

Developing Optogenetic Approaches To Study Ca2+ Signaling Processes, Tatsuki Nonomura, Xiaoxuan Liu, Megan Chiu, Zhi Tan, Tien-Hung Lan, Yubin Zhou

Faculty, Staff and Students Publications

Calcium ions (Ca2+) are essential second messengers intimately implicated in a variety of biological processes, ranging from short-term events such as muscle contraction to long-term effects like gene expression. Dysregulated Ca2+ signaling can disrupt cellular function and contribute to the development of various human diseases, including developmental, neurological, immunoinflammatory, metabolic, and cardiovascular disorders. To study the mechanisms and biological consequences of Ca2+ signaling, optogenetic approaches have proven invaluable, as they offer exceptional spatiotemporal resolution compared to traditional methods. Recent progress in non-opsin-based optogenetics, particularly those engineered from Ca2+ release–activated Ca2+ (CRAC) channels, has substantially advanced our understanding of Ca2+ signaling …

An Annotated Biobank Of Triple-Negative Breast Cancer Patient-Derived Xenografts Features Treatment-Naïve And Longitudinal Samples During Neoadjuvant Chemotherapy, Amanda L Rinkenbaugh, Yuan Qi, Shirong Cai, Jiansu Shao, Faiza Baameur Hancock, Sabrina L Jeter-Jones, Xiaomei Zhang, Emily Powell, Lei Huo, Rosanna Lau, Chunxiao Fu, Rebekah Gould, Petra Den Hollander, Elizabeth E Ravenberg, Jason B White, Gaiane M Rauch, Banu Arun, Clinton Yam, Alastair M Thompson, Gloria V Echeverria, Stacy L Moulder, W Fraser Symmans, Jeffrey T Chang, Helen Piwnica-Worms

Faculty, Staff and Student Publications

Triple-negative breast cancer (TNBC) that fails to respond to neoadjuvant chemotherapy (NACT) can be lethal. Developing effective strategies to eradicate chemoresistant disease requires experimental models that recapitulate the heterogeneity characteristic of TNBC. To that end, we established a biobank of 92 orthotopic patient-derived xenograft (PDX) models of TNBC from the tumors of 75 patients enrolled in the ARTEMIS clinical trial (NCT02276443), including 12 longitudinal sets generated from serial patient biopsies collected throughout NACT treatment and from metastatic disease. Models were established from both chemosensitive and chemoresistant tumors, and nearly 30% of the PDX models were capable of metastasizing …

Burden Of Central Nervous System Cancer In The United States, 1990-2021, Hyun Jin Han, Yun Seo Kim, Seoyeon Park, Jae Il Shin, Min Seo Kim, Ju Hyung Moon, Yong Bae Kim, Hazim S Ababneh, Ahmed Abu-Zaid, Demelash Areda, Santhosh Arul, Ahmed Y Azzam, Mainak Bardhan, Mohammad Amin Bayat Tork, Babak Behnam, Gokce Belge Bilgin, Prarthna V Bhardwaj, Soumitra S Bhuyan, Nima Broomand Lomer, Meng Xuan Chen, Suma Sri Chennapragada, Xiaochen Dai, Frances E Dean, Sindhura Deekonda, Xueting Ding, Ojas Prakashbhai Doshi, Abdel Rahman E'Mar, Muhammed Elhadi, Jawad Fares, Patrick Fazeli, James L Fisher, Maryam Fotouhi, Ali Gholamrezanezhad, Fidelia Ida, Chidozie Declan Iwu, Mohamed Jalloh, Chinmay T Jani, Rizwan Kalani, Samuel Berchi Kankam, Foad Kazemi, Ariz Keshwani, Atulya Aman Khosla, Stephen S Lim, Riffat Mehboob, Tomislav Mestrovic, Ali H Mokdad, Christopher J L Murray, Gurudatta Naik, Zuhair S Natto, Dang Nguyen, Fred Nugen, Atakan Orscelik, Romil R Parikh, Louise Penberthy, Richard G Pestell, Disha Prabhu, Jagadeesh Puvvula, Shakthi Kumaran Ramasamy, Cameron John Sabet, Austin E Schumacher, Yigit Can Senol, Sunder Sham, Samendra P Sherchan, Gizeaddis Lamesgin Simegn, Jasvinder A Singh, Ranjan Solanki, Bahadar S Srichawla, Jabeen Taiba, Manoj Tanwar, Mike Tuffour Amirikah, Anjul Verma, Ismaeel Yunusa, David X Zheng, Dong Keon Yon, Keun Young Park

Faculty, Staff and Students Publications

Importance: Primary brain and central nervous system cancer (collectively referred to as CNS cancer) comprises 2% of all human cancers and poses significant health and economic challenges in the United States.

Objective: To analyze CNS cancer burden in the US, stratified by time, location (state and division), sex, age group, and Sociodemographic Index (SDI).

Design, setting, and participants: This cross-sectional study involved a repeated analysis of Global Burden of Disease Study (GBD) 2021 data in 2024. Using data from 183 sources, CNS cancer metrics in the US were estimated across states and years. US CNS cancer metrics across all sexes …

Posttraumatic Growth Following Pregnancy Loss: Understanding The Influence Of Positive Religious Coping And The Moderating Effect Of Perceived Social Support, Maria Alayza

Electronic Theses and Dissertations 2020 - Present

The purpose of this research study was to examine positive religious coping, perceived social support, and posttraumatic growth (PTG) among bereaved mothers who had experienced pregnancy loss. I aimed to inform counselors about the nuances of the aftermath of pregnancy loss, as well as the protective and risk factors of PTG. The final sample consisted of 154 bereaved mothers who thoroughly completed a demographic questionnaire, the Positive Religious Coping subscale of the Brief Religious Coping Scale (Brief R-COPE), the Posttraumatic Growth Inventory–Expanded (PTGI-X), and the Multidimensional Scale of Perceived Social Support (MSPSS). I utilized the IBM Statistical Package for the …

Music As A Strategy To Improve Hypertension And Stroke Management: Evidence From A Crowdsourcing Open Call And Designathon In Nigeria, Chidi Okafor, Shravya Allena, Olufunto A Olusanya, Titilola Gbaja-Biamila, Temitope Ojo, Juliet Iwelunmor, Et Al.

2020-Current year OA Pubs

BACKGROUND: In Nigeria, cardiovascular diseases, especially hypertension, are on the rise. This increase in hypertension correlates with more strokes, significantly impacting mortality. Since hypertension often persists into adulthood, early interventions are crucial to prevent its complications. Non-invasive methods, such as music and creative activities, can effectively improve blood pressure and reduce stroke risk. This study aims to improve intergenerational awareness of hypertension and promote sustainable preventive practices by involving youth and caregivers within families and communities.

METHODS: We employed a participatory, observational design, incorporating a five-month crowdsourcing open call followed by a designathon event. Participatory social and health innovations were …

The Impact Of Geographic And Community Diversity On The Transitionary Experiences Of International College Athletes, Marek Taškár, Chris Corr, Nicole Sellars, Sarah Stokowski, Karina Jolly, Trevor Bopp

Journal of Issues in Intercollegiate Athletics

International college athletes migrating to the United States for athletic competition encounter unique challenges such as language barriers, cultural adjustment, and familial detachment. These obstacles can hinder international college athletes’ transition compared to those of domestic athletes. While supportive programming and personnel have been illustrated to ease the transition and foster acculturation among international college athletes, the impact of the geographic location of an institution may impact the acculturation process for international college athletes. Given the importance of acculturation to athletic and academic success, this study examined how cultural diversity within communities hosting NCAA member institutions affects international college athletes’ …

Ethical Leadership: Rooted, Open, Generative, And Mindful, John Arthur Nunes

Intersections

No abstract provided.

Full Issue

Intersections

No abstract provided.

Building A Third Space In The Age Of Ai : A Conversation With Dr. Walter Earl Fluker, Elizabeth Kubek

Intersections

No abstract provided.

Moderators Of Peer Influence Effects For Adolescents’ Smoking And Vaping Norms And Outcomes In High And Middle-Income Settings, Jennifer M. Murray, Sharon C. Sánchez-Franco, Olga L. Sarmiento, Erik O. Kimbrough, Christopher Tate, Shannon C. Montgomery, Rajnish Kumar, Laura Dunne, Abhijit Ramalingam, Erin L. Krupka, Felipe Montes, Huiyu Zhou, Laurence Moore, Linda Bauld, Blanca Llorente, Frank Kee, Ruth F. Hunter

Economics Faculty Articles and Research

Background: Peer influence is central to adolescent smoking initiation, yet its impact varies depending on individual and contextual factors. Understanding which moderators (personality, contextual, cultural, and environmental traits) shape these processes can inform more effective prevention strategies. We investigated hypothesized moderators of peer influence for adolescent smoking/vaping norms and other smoking-related outcomes in high and low-middle-income countries (LMICs): Northern Ireland and Bogotá.

Methods: Across 12 schools (n = 1,344, age 12–13 years), participants completed novel behavioral economics experiments measuring social norms, and self-report surveys, before and after school-based prevention interventions (ASSIST and Dead Cool). We examined how peer influence …

Ready Or Not? Merits Of An End-Of-Fourth-Year Summative Osce, Shruti Chandra, Md, Mehp, Deborah Ziring, Md, Katherine Berg, Md, Mph, Stefani Russo, Md

JeffMD Academic Affairs

Purpose

To develop a summative OSCE for fourth-year medical students to assess core clinical skills for internship readiness and remediate low performers.

Program directors report gaps between expectations and interns’ skills.

End of clerkship OSCEs, End of third-year summative OSCE

• Different competencies assessed
• Not reflective of graduation skills

An end-of-fourth-year summative OSCE was developed to

• Assess advanced reasoning and communication
• Assure residency readiness
• Identify and remediate clinical skills deficiencies

The Role Of The Preamble: Evidence From The Constitutional Convention And The Ratification Debates, Stuart Ford

Texas A&M Law Review

This Article explores the role of the Preamble in constitutional interpretation by looking at how it was perceived at the founding. It does this in three ways. First, it explores how preambles were used in eighteenth-century America. At the time, preambles were almost universally understood to be key to interpreting the laws and constitutions they preceded. This shared understanding forms the backdrop against which the Preamble was received by the founding generation. Second, it looks at the records of the Constitutional Convention for evidence of what role the drafters expected the Preamble to serve. Unfortunately, the records of the Convention …

Proteomic Perspectives On Kras-Driven Cancers And Emerging Therapeutic Approaches, Ramesh Karki, Ru Chen, Sheng Pan

Faculty, Staff and Student Publications

KRAS mutations are implicated in approximately 23% of all human malignancies, with particularly high prevalence in pancreatic ductal adenocarcinoma (PDAC) (~92%), colorectal cancer (CRC) (~49%), and non-small cell lung cancer (NSCLC) (~35%). The recent approval of the KRASG12C-specific inhibitors for NSCLC represents a pivotal advancement in KRAS-targeted therapy. Nevertheless, the emergence of intrinsic and acquired resistance to KRAS-targeted therapies poses a significant clinical obstacle to targeting KRAS, which necessitates a deeper understanding of the resistance mechanisms. Recent progress in proteomic studies has enabled comprehensive profiling of the proteomic alterations driven by KRAS mutations, offering valuable insights into the disrupted KRAS …

The American Friends Of Irish Neutrality And The American Irish Defense Association: The Last Irish American Committees, Patrick J. Horan

USF Tampa Graduate Theses and Dissertations

This dissertation examines the complex narratives surrounding Irish neutrality during World War II within the Irish American community. It focuses on two key organizations, the American Friends of Irish Neutrality (AFIN) and the American Irish Defense Association (AIDA), arguing that the conflict over neutrality was a pivotal moment in the assimilation of Irish American identity. The study explores how Irish Americans balanced their connection to their ancestral homeland with their desire for full acceptance in the United States.

The research reveals a fervent propaganda war between the AFIN, a grassroots organization defending Ireland’s right to remain neutral, and the AIDA, …

Ireland Blossoms Through Multiculturalism - Designing For Community Connection, Julia Kuczera, Shirley Casey, Hilary Kenna

SURE Journal: Science Undergraduate Research Experience Journal

No abstract provided.

The Impact Of Chronic Pain On Income And Employment, Jordan Vaarsi, Amber Jolly, Karim S. Ladha

SURE Journal: Science Undergraduate Research Experience Journal

No abstract provided.

The Tax Adviser, Volume 2, Number 10, October 1971, American Institute Of Certified Public Accountants

Tax Adviser

No abstract provided.

Machine Learning And Deep Learning Applications In Sports Biomechanical Analysis: A Systematic Scoping Review Of Performance Enhancement And Injury Prevention Strategies, Wissem Dhahbi, Nidhal Jebabli, Manar Boujabli, Marouen Souaifi, Ismail Dergaa, Lamia Ben Ezzdine

ISBS Proceedings Archive

Aim: This scoping review systematically maps current trends in artificial intelligence applications for sports biomechanical analysis, examining performance enhancement and injury prevention utility, methodological approaches, implementation challenges, and ethical considerations. Methods: A comprehensive analysis synthesized evidence on AI methodologies applied to sports biomechanics across various contexts, including machine learning, neural networks, and deep learning approaches integrated with learning management systems. This review examined data collection modes, analytical approaches, and practical implementation in laboratory and field settings. Results: AI applications evolved from basic statistical modeling to sophisticated machine learning configurations, demonstrating superior performance in technique analysis (94% agreement with international judges), …

Within-Session Variability In Treadmill Running Mechanics In Team Sport Athletes, Claire Chaisson, Brian Hanley, Dan Weaving, Stacey Emmonds

ISBS Proceedings Archive

This study investigated within-session variability in treadmill running mechanics during repeated same-day runs across multiple speeds, with a secondary aim to assess how these mechanics changed with speed. Eleven team sport athletes (9 M, 2 F; 25.0 ± 3.2 years) completed three trials of 30-s treadmill runs at 10, 12, 14, 16, 18 and 20 km/h. The coefficient of variation (CV%) for step length (2.7 to 1.7%, β = -0.10, p = 0.004) and flight time (7.9 to 4.3%, β = -0.41, p < 0.001) decreased with speed, indicating greater consistency. Step length (β = 0.068), step rate (β = 0.054), flight time (β = 3.69) and horizontal work (β = 0.026) increased with speed, and contact time (β = –9.86), duty factor (β = –0.008) and vertical work (β = –0.041) decreased. These findings suggest movement patterns become more consistent at higher speeds.

Bermuda Trust: Why And How, Julian S. Bush

Tax Adviser

No abstract provided.

Volume 12 Issue 2 (Nov 1912)

The Soul Winner

No abstract provided.

Measuring Student Growth To Support Organizational Learning Using The Academic Progress Indicator (Api): An Evaluation Of Chicago Public Schools’ New Student Progress Metric, Benjamin Boer

Reports, Analyses, and other Publications

A report on early implementation of the Academic Progress Indicator (API), a student progress measure developed by Chicago Public Schools (CPS) as part of its new Continuous Improvement and Data Transparency (CIDT) system. The API represents a significant step forward in how schools and communities can use data to understand and support student learning.

Comparison Of Human Versus Genai Generated Measurements Of Personal Beauty Values, Fumiko Kano Glückstad, Kohei Kanno, Hiromi Kobayashi, Rie Nakamura

Papers from the International Association for Cross-Cultural Psychology Conferences

It is a challenging task to develop a scale to measure psychological constructs in a non-native language. In this study, we compared reliability and validity of a scale to measure five dimensions of Personal Beauty Values (PBV) generated by ChatGPT4 with a human-generated PBV scale. The original human-generated PBV scale in English consists of 14 items divided into five dimensions. The limitation of this scale developed by non-native English speakers is a restricted number of items, which will potentially limit the applicability of the scale to other cultural contexts. To complement this weakness, we generated additional items of the five …

#Willsmith: Text Analyses Of X Posts About The Oscar Slap, Merrisa Lin, Nairán Ramírez-Esparza

Papers from the International Association for Cross-Cultural Psychology Conferences

Social media users share their thoughts on social events, offering insights into the sociocultural climate. Since language reflects related culture, analyzing social media discussions in different languages provides a window into the sociocultural context. In this exploratory study, we examined English and Spanish posts related to the Oscar Slap, which sparked race and gender discussions. We analyzed X posts with #willsmith hashtag in English (N = 28,717) and in Spanish (N = 4,251). The Meaning Extraction Method automated text analyses revealed three similar themes across language cultures, a theme specific to English posts, and two themes unique to Spanish posts. …

Factors Influencing Flourishing In Autoimmune Patients: A Systematic Review, Amherstia Pasca Rina, Endang R. Surjaningrum

Papers from the International Association for Cross-Cultural Psychology Conferences

This scoping literature review aimed to identify factors that influence flourishing and to synthesize gaps in previous studies that flourishing is not only influenced by the internal factor but how the social conditions individuals live in can also affect flourishing. Autoimmune diseases are incurable and associated with mental health conditions that can exacerbate the intensity of recurrence, so it is necessary to take protective measures, namely flourishing as a form of behavioral management of chronic diseases. The prevalence of autoimmune patients who are declared flourishing is relatively small, but flourishing is actually a psychological concept that is needed by everyone …

Home Care Workers, Immigration, And An Aging Population, Catherine Ipsen, Luke Santore

Employment

The size of the Home Care Worker (HCW) workforce has not kept pace with demand, and inadequate compensation and benefits have historically contributed to poor HCW recruitment and retention. Demographic trends put further strain on the workforce, with immigrants, naturalized citizens, and Black and Indigenous People of Color (BIPOC) individuals currently making up the majority of the HCW workforce.

Policy changes, cuts to benefits, and immigration crackdowns threaten to further weaken the supply of HCWs while the demand continues to rise. In this report, Catherine Ipsen and Luke Santore provide analysis and strategies to support HCWs and strengthen the Personal …

Impact And Effectiveness Of Phq-9 Training For School Counselors On Mental Health Referrals For High School Students, Sherikee Dorice Grim Bsn, Rn, Ja’Quay Brister Dnp, Pmhnp-Bc, Margaret Harvey Phd, Aprn, Acnp, Chfn, Fhrs

Doctor of Nursing Practice Projects

Purpose/Background

Adolescents' mental health has worsened and become a public health issue, with depression being a primary concern. There is an urgent need for early screening, school-based referral pathways, and interventions to address common problems in high schools. Patient Health Questionnaire-9 (PHQ-9) is a validated, evidence-based tool for detecting depression; however, its systematic use in school-based counseling settings through organized training has not been studied for implementation in high schools. This review assesses the current literature on the impact and effectiveness of PHQ-9 training for school counselors on mental health referrals among high school students, with a focus on early …

Introduction, James Chukwuma Okoye Cssp

Spiritan Horizons

No abstract provided.

A Journey In Prayer With Father Libermann, Marc Whelan Cssp

Spiritan Horizons

No abstract provided.