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Rabies Virus-Vectored Lyme Disease Vaccine Provides Long-Term Protection Against Tick-Transmitted Borrelia Burgdorferi, Shantel Rios, Bibek Bhattachan, Christoph Wirblich, Anisha Chandwani, Kruthi Vavilikolanu, Jacob F. Myers, Chrysoula Kitsou, Utpal Pal, Matthias J. Schnell

Department of Microbiology and Immunology Faculty Papers

Lyme disease (LD) cases have doubled globally. LD is a tick-borne illness caused by the Borrelia burgdorferi sensu lato (Bb). If untreated, Bb can disseminate to distal organs, causing carditis, arthritis, and meningitis. Currently, no FDA-approved human LD vaccine exists on the market. This study used two approaches to incorporate OspA into the rabies virus (RABV) vaccine vector. We used the RABV-glycoprotein tail (RVG tail) and the Hendra virus (HeV) glycoprotein tail (HVG tail) to incorporate OspA, creating BNSP333-OspA-RVG and BNSP333-OspA-HVG, respectively. Both vaccines produced type-1 biased anti-OspA antibodies, but only BNSP333-OspA-HVG induced neutralizing antibodies and protected against Bb infection. …

Novice Teacher Voice Of Preservice Preparation To Support Low-Ses Students, Edna Richardson Richardson Billingsley

Walden Dissertations and Doctoral Studies

The problem that was addressed through this study was that there is a gap in the literature about the preparation of mid to lower elementary novice teachers to teach students with low-socioeconomic status (low-SES) in several districts throughout the Southern United States. Grounded in social justice theory, the purpose of the basic qualitative design was to explore lower to middle elementary teachers' perceptions on their preservice preparation to teach low-SES students. For this basic qualitative design, 12 novice teachers participated in semistructured interviews. Data were analyzed through thematic analysis with the following three top themes emerging: (a) poor preparation towards …

Bridging The Knowledge Gap Of Nursing Staff Understanding Patient Medication Discharge Instructions, Tracy L. Outlaw

Walden Dissertations and Doctoral Studies

The project, a Doctor of Nursing Practice (DNP) staff education project, addresses a gap in nursing practice by focusing on the need for comprehensive knowledge and effective communication skills among nursing staff regarding antidepressant discharge instructions. The practice-focused question is as follows: How does a structured educational program on antidepressant pharmacology and communication strategies impact staff knowledge and satisfaction compared to standard discharge practices? The primary purpose of the project is to improve nursing staff knowledge and communication through a systematic, phased approach that aligns with project management principles through the lens of project management theory, thereby increasing and sustaining …

Impact Of Staff Education On Cultural Competency Knowledge And Skills, Okechukwu Cyril Akunwafor

Walden Dissertations and Doctoral Studies

Summary The Doctor of Nursing Practice (DNP) project involved implementing a cultural competency staff education program at an outpatient mental health clinic. The identified practice problem was poor cultural competence practices knowledge among staff, resulting in poor patient engagement and a low patient satisfaction rate. Improving cultural competency in nursing practice was necessary to facilitate therapeutic trust, increase patient treatment adherence, and enhance staff compliance with Culturally and Linguistically Appropriate Services (CLAS). The practice-focused question guiding the DNP project was: Does implementing staff education impact their knowledge of cultural competence and confidence in adhering to CLAS? Data were collected through …

Experiences And Training Of Early Childhood Education Directors, Rochelle Elaine Nadeau

Walden Dissertations and Doctoral Studies

In Colorado, early childhood education (ECE) directors are often not fully prepared to lead and develop high-quality teaching teams, which is integral to offering high-quality programming to children and families in the early years of development. Framed by transformational leadership theory, the purpose of this basic qualitative study was to explore Colorado ECE directors' experiences with training and support, and the resources needed to develop ECE directors to lead high-quality programming . Data were collected through semistructured interviews with 13 Colorado ECE directors from center-based programs that serve children from birth to 8 years. Thematic analysis using open coding yielded …

Staff Education To Improve Cultural Competence In Mental Health Care, Mariam Farah

Walden Dissertations and Doctoral Studies

This doctoral project addressed a gap in staff cultural competence at a mental health and addiction services center in the Midwest. I conducted this project to design, implement, and evaluate a staff educational program to improve staff knowledge, cultural awareness, and communication skills. The guiding practice-focused question was: Among staff at the Midwest mental health and addiction services center, how does a structured cultural competence education program compare to current practices in improving staff knowledge of cultural awareness? A 2-day educational session was held to accommodate participation within regular work schedules without interfering with the project site organization’s services. Arrangements …

Prevalence Of Potentially Inappropriate Medications In People Living With Hiv: A Systematic Review And Meta-Analysis, Mustapha Muhammed Abubakar, Abdulmuminu Isah, Ruth Jeminiwa, Ibraheem Abioye, Ismaeel Yunusa, Mohammed Abba-Aji, Osagie Kenneth Cole, Jamila Sani, Mukhtar Ijaiya, Chukwuemeka Nwachuya, Yusuf Ibrahim, Mustapha Usman, Duke Daniels, Oluwaseun Samuel Ilugbuhi, Blessing Onyinye Ukoha-Kalu

College of Pharmacy Faculty Papers

BACKGROUND: Potentially inappropriate medications (PIM) are associated with adverse health outcomes. The use of PIM among persons living with HIV (PLHIV) could be more problematic due to peculiarities such as antiretroviral toxicity and drug-disease interactions. However, PIM among PLHIV continues to receive little attention. Therefore, we aimed to systematically review and estimate the prevalence of PIM among PLHIV.

METHODS: We searched the PubMed, Scopus, and Web of Science databases to identify relevant studies from 1 January 2014 to 30 June 2024. Studies included were peer-reviewed articles that determined PIM prevalence using validated explicit or implicit tools and provided statistical information …

Efficacy Of Medical-Legal Partnerships To Address Health-Harming Legal Needs: A Systematic Review Of Experimental Studies In The Field, Jemima John, Thomas Murphy, Emily Zientek, Winston Liaw, Odinakachukwu Dimgba, Thien-An Nguyen, Catherine Burnett, Mary Aitken, Shreela Sharma

Faculty, Staff and Student Publications

Background: Despite the documented success of medical-legal partnerships (MLPs), there is a dearth of robust experimental-based research on their efficacy. This review synthesizes the findings of MLP interventions and identifies opportunities for MLP expansion in vulnerable communities.

Methods: Articles were eligible if they tested the experimental effects of an MLP intervention on health-harming legal needs (HHLNs) and had full text for review. Two reviewers independently screened articles for inclusion and assessed the quality (risk of bias) of each study.

Results: Seven studies were eligible. Populations were largely women, of color, and of lower socioeconomic status. All studies demonstrated positive effects …

Research Review: "Experiences Of Women And Minoritized Us Military Veteran Business Owners: Descriptive Evidence On "Vetrepreneur" Survival And Growth, Institute For Veterans And Military Families At Syracuse University

Institute for Veterans and Military Families

This research examines the survival and growth of U.S. veteran-owned businesses, focusing on gender and race disparities. Using longitudinal microdata from 1976–2019, the study reveals that veteran-owned firms exhibit higher survival rates, greater revenues, and strong payroll performance compared to nonveteran businesses, though they experience lower employment growth. Women veterans show notable resilience, suggesting military experience helps mitigate gender gaps in entrepreneurship. Findings highlight the need for targeted policies, such as improved access to capital and workforce planning, to support scaling among women and minority veteran entrepreneurs. The study provides critical insights for policymakers and future research on vetrepreneurship.

Student Perspective Of Motivation And Success In Online Learning, Jonathan Samuel Long

Doctoral Dissertations and Projects

The purpose of this case study was to understand the perceptions of how motivation influences success in online courses for students at a rural high school in the North Georgia. The theory guiding this study was motivation theory, including growth mindset theory, self-determination theory, and adult learning theory. The central research question for this study is, “What are high school students’ perceptions of the influence of motivation on success in an online course?” This study utilized a case study approach in a rural high school in Northeast Georgia to qualitatively analyze data. Data was collected through a letter-writing exercise, personal …

Mental Health Among Minorities In Law Enforcement Positions, Sydnee Monet Brown

Doctoral Dissertations and Projects

Law enforcement officers often deal with complex work environments, including negative public opinions, challenging legal systems, and resource constraints. These factors can compound to make officers' work more psychologically stressful. This is especially true for minority officers who also have to deal with daily incidents of prejudice, discrimination, and cultural misunderstandings within the police force. The current qualitative phenomenological study employed semi-structured interviews to investigate the experiences of minority police officers, in an effort to gain more insight into their mental health experiences. The results of this study show that discrimination, systemic issues, and stigma associated with accessing psychological help …

A Phenomenological Study On The Influence Of Teacher Perceptions On Play-Based Learning, Courtney Simpson

Doctoral Dissertations and Projects

The purpose of this phenomenological study was to describe the lived experiences of implementing play-based learning for teachers at early childhood settings in Georgia. The theory guiding this study was Jon Dewey’s theory of experiential learning, as it addressed the significance of children learning through play. The Central Research Question was: What are the experiences of teachers implementing play-based learning in early childhood settings in Georgia? A qualitative methodology approach utilizing transcendental phenomenology was taken to describe the lived experiences of 13 teachers implementing play-based learning. The setting included early learning centers and schools in Georgia. A combination of snowball …

Exploring Collaborative Engagement To Meet The Academic Needs Of Multilingual Learners: A Case Study, Shannon M. Smith

Doctoral Dissertations and Projects

This qualitative case study described the collaborative engagement of middle school teachers to address the academic needs of multilingual learners in Pennsylvania. The central research question that guided the study was: How do teachers collaborate to address the academic needs of multilingual learners in content classrooms? In addition, guiding questions were implemented to understand the phenomenon of collaborative engagement among middle school teachers. The guiding questions were: How does collaborative engagement shape academic and language learning for multilingual learners? How does the culture of collaborative engagement support social interactions as a scaffold? Sociocultural theory guided the study. Sociocultural theory is …

Atonement As The Path To Holiness: The Suffering Servant Of The Fourth Servant Song As The Missing Sacrifice Of Isaiah 6, William Anthony Whitfield

Doctoral Dissertations and Projects

This study argues that the Suffering Servant of the Fourth Servant Song (SS4, Isaiah 52:13-53:12) is the missing sacrifice of Isaiah 6. This conclusion is supported by the multitude of intertextual links between these two hallmark texts of Isaiah, including language of exaltation, messianic imagery, and, most notably to the current study, atonement imagery, specifically as it relates to being an avenue to holiness. This study addresses the necessity for a sacrifice in Isaiah 6, although no sacrifice is explicitly mentioned. Atonement is the central theme of SS4, where the Suffering Servant is depicted as being given as a guilt …

Divine Intervention Emphasized In Ptsd Treatment Strategies, Zachary R. Kuster

Doctoral Dissertations and Projects

This study examined how theological concepts might enhance PTSD treatment outcomes by challenging existing paradigms within evidence-based interventions. While some therapeutic models acknowledge the value of integrating theological concepts within treatment, little empirical evidence explains how emphasizing the theological concepts that may already exist within evidence-based strategies may enhance the overall efficacy of treatment. In this study, an experimental group received strategies emphasizing grace, hope, and forgiveness, while a control group received strategies without these emphases. The PCL-5 psychometric assessment tool was used to measure changes across two 4-week PTSD programs that incorporated 48 strategies from the same four therapeutic …

Identification Of Optimal Knowledge Transfer Methods From Generation X To Millennials, Maria Nanci Denmark

Doctoral Dissertations and Projects

This qualitative study uses a descriptive phenomenological approach to examine the experience and insights of Generation X and Millennial software engineers employed by the United States government on their preferred methods for tacit knowledge transfer. Phenomenological examination allows for the structured exploration and documentation of common themes and fundamental structures across the generational cohorts. Participants were selected based on inclusion criteria that produced a sample that shared common training and career paths split evenly across the two generations. Using Colaizzi’s Seven Step Method for analysis, the researcher led semi-structured interviews producing data that provided a clear description of the themes …

A Comparative Analysis Of K–12 Public School Music Teacher Burnout From 1986 To 2025, Veronica A. Rovatti

Doctoral Dissertations and Projects

This historical comparative analysis assessed five different sources to understand the effect stress and burnout have had on public school music educators over the last fifty years. In the United States, music educators are facing stress and burnout in their teaching careers, which can result in attrition from their profession. In this research study, four studies pertaining to music educator burnout are analyzed through a narrative compilation of research already established. Also analyzed is a supplementary recent article providing contemporary relevance. The criteria for source selection included studies or articles that primarily researched stress and burnout among K-12 public school …

Understanding The Influence Of Declining Nursing Motivation On Hospital Performance: A Qualitative Mixed Method Case Study, Kisena J. Leverette

Doctoral Dissertations and Projects

This qualitative single-case study examined how a decline in nursing motivation affects nurse retention and organizational performance in a large urban hospital in Cincinnati, Ohio. The data were collected through in-depth interviews with nurse managers and anonymous surveys administered to registered nurses, resulting in a total of 20 participants. There were three emergent themes discovered from the findings from the interview transcripts and survey responses. Supportive leadership, intrinsic and extrinsic factors, safe staffing and workplace management were the primary emergent themes for this research. This research revealed that open communication, fair compensation, and proactive support from leadership are imperative. Additionally, …

Shaping The Hills: Women Folklorists And Writers In The Ozarks And The Advancement Of A Romanticized Regional Identity And Heritage Tourism, Rachel Pendergraft

Doctoral Dissertations and Projects

This study examines how women folklorists and writers in the Ozarks, between 1930 and 1970, shaped a romanticized regional identity, preserved its history, and, as cultural representatives, reframed the perception of the region, thus facilitating the advancement of heritage tourism. This development is further explored within the context of a national framework. Moreover, by focusing on three women, May Kennedy McCord, Mary Elizabeth Mahnkey, and Lucile Morris Upton, and using them as key analytical tools, a broader assessment of women’s contributions to Ozark cultural identity and their leadership in the development of heritage tourism is achieved. Drawing on archival material …

A Qualitative Intrinsic Case Study For A Christian Marriage Mentorship Program In Kentucky, Victoria Barbour

Doctoral Dissertations and Projects

The purpose of this intrinsic qualitative case study was to explore the marriage mentorship program of Glory Carriers Church (pseudonym) a non-denominational Christian ministry in central Kentucky to be a larger model for other churches that may also have or want to build their marriage mentorship program. The theories guiding this study are social constructivism therapy, the wraparound model, solution focused therapy, emotion focused therapy and last, the Gottman Method: Sound relationship house. The central research question asked, “What programs does Glory Carriers Church provide for married couples?” with Sub-question 1 that asked, “How does this program provide wraparound support …

Mental Well-Being, Belonging, And Chronic Absenteeism: A Correlational Study, Crystal D. Woodall

Doctoral Dissertations and Projects

Chronic absenteeism (CA) is an overwhelming issue facing schools in the United States. A lack of a student’s sense of belonging or signs of emotional symptoms are often red flags that can forecast future absenteeism problems with students. CA has been found to have a positive correlation with a student’s sense of belonging and emotional symptoms. Some CA interventions are geared toward increasing a student’s sense of belonging at school and or improvements in overall mental well-being. The purpose of this predictive correlational study was to examine the relationship between students’ self-reported levels of peer relationship problems and emotional symptoms, …

Acculturative Stress Among Immigrant High School Graduates In North Carolina: A Hermeneutic Phenomenological Study, Caren P. Morgan

Doctoral Dissertations and Projects

Global migration will continue to escalate in the future. In this transition process, the United States is a popular destination. Migrants are motivated by a variety of factors, including education, employment, and research. The purpose of this hermeneutic phenomenological study aimed to better understand lived experiences of acculturative stress among immigrant high school graduates in North Carolina. This qualitative design sought to get answers to the central research question: What are the lived experiences of immigrant high school graduates who encountered acculturative stress? The theoretical framework includes two theories that are essential to this study: acculturation theory, and resilience theory. …

Developing A General Ai Model For Integrating Diverse Genomic Modalities And Comprehensive Genomic Knowledge, Zhenhao Zhang, Xinyu Bao, Linghua Jiang, Xin Luo, Zheyu Zhang, Jing Yin, Meiqi Zhao, Yichun Wang, Annelise Comai, Joerg Waldhaus, Anders S Hansen, Wenbo Li, Jie Liu

Faculty, Staff and Student Publications

Advances in next-generation sequencing technologies have vastly expanded the availability of diverse genomic, epigenomic, and transcriptomic data, presenting the opportunity to develop a general AI model that integrates comprehensive genomic knowledge into a unified model. Unlike previous predictive models, which are typically specialized to certain tasks, our general AI model unifies a wide range of genomic modalities, such as nascent RNA and ultra-high-resolution chromatin organization, within a multi-task architecture. Using ATAC-seq and DNA sequences as inputs, we incorporated diverse genomic modalities as output, and the model exhibits strong generalizability across different cell types and tissues in all tasks we trained. …

The Unfolded Protein Response-Novel Mechanisms, Challenges, And Key Considerations For Therapeutic Intervention, P M Quan Mai, Tam-Anh Truong, Sai Kumar Samala, Bhoomika Muruvekere Lakshmisha, Prapannajeet Biswal, Khadijeh Koushki, Prudhvi Chand Mallepaddi, Geraldine Vijay, Sunil Krishnan

Faculty, Staff and Student Publications

Background: The unfolded protein response (UPR) is an evolutionarily conserved, synchronized, and orchestrated process triggered by eukaryotic cells in response to endoplasmic reticulum (ER) stress. UPR restores the ER's capacity to handle large protein loads within it, and still fold and process these proteins accurately. Many recent studies have documented the non-canonical roles of the UPR, outside of protein quality control, in the context of lipid metabolism and the immune system in cancer. Cancer cells have been known to hijack the UPR to promote survival and evade immune surveillance. However, the underlying mechanisms remain poorly understood.

Objectives: Here, we critically …

Primary Intramedullary Spinal Melanocytomas: Case Report And Review Of Clinical Features, Diagnosis, And Management, Gil Kimchi, Samantha Varela, Juan Pablo Zuluaga-Garcia, Francisco Call-Orellana, Esteban Ramirez Ferrer, Romulo Augusto Andrade De Almeida, Maria A Gubbiotti, Isabella C Glitza, Andrew J Bishop, Jonathan D Grant, Robert Y North, Christopher A Alvarez-Breckenridge, Laurence D Rhines, Claudio E Tatsui

Faculty, Staff and Student Publications

Objective: Intramedullary melanocytomas are extremely rare spinal cord tumors with distinct histopathological and imaging characteristics. This report reviews the literature on this pathology and presents a representative case study, highlighting aspects of diagnosis and management.

Methods: A scoping review of PubMed, Web of Science, and Embase databases was conducted to identify reports on intramedullary melanocytomas, focusing on clinical presentation, imaging features, histopathology, treatment, and outcomes. Case reports and case series were included due to the rarity of these tumors.

Results: Twelve manuscripts met the inclusion criteria, including 15 patients. In the majority of patients, intramedullary melanocytomas present with progressive myelopathy …

Just In Time: The Definitive Reconstruction Of Biblical Chronology From Adam To The Apostolic Age, James Allen Moseley

Doctoral Dissertations and Projects

By embedding a relational database of chronology within Scripture, the inspired authors handed down a framework so precise that it surpasses archaeology, carbon dating, and every other ancient record as the most reliable means of reconstructing history—shedding light on the why and how of biblical events by specifying their when.

This study defends that thesis, demonstrating that the Bible presents a continuous timeline from Adam to Christ—a mathematically coherent whole often overlooked or misunderstood by modern scholarship. Many modern chronologists assign speculative dates to Abraham, Moses, or David without grounding them in the Genesis genealogies. Few construct a defensible framework …

Exploring Professors’ Lived Experiences Of Interacting With Artificial Intelligence In The Classroom: A Phenomenological Study, Joshua A. Baltzell

Doctoral Dissertations and Projects

The purpose of this hermeneutic phenomenological study was to explore the lived experiences of higher education professors’ interactions with AI in their teaching practices. This study was guided by Ajzen’s theory of planned behavior, which provided a contextual understanding of the concepts that influence higher education professors’ perceptions of AI in their classrooms. A qualitative hermeneutical phenomenological design was employed, utilizing a combination of criterion and snowball sampling. There were 13 participants recruited from higher education institutions from around the United States. Semi-structured individual interviews, a letter-writing exercise, and a qualitative survey were used to collect data from participants. Thematic …

Promoting Leadership To Enhance Safety In Aircraft Maintenance: A Phenomenological Study Of Aviation Technical Operations, Komi Tete

Doctoral Dissertations and Projects

The purpose of this qualitative phenomenological study was to explore how leadership styles affect the safety practices and overall performance of aircraft maintenance technicians (AMTs) in aviation Technical Operations (TechOps) environments. The study built on previous research indicating that safe and efficient aircraft operations depend on numerous technical and social processes. It focused on the comprehensive lived experiences of AMTs as they related to leadership influence on safety. The transformational leadership theory and safety culture theory guided the study, aligning with the inquiry by explaining how leaders could influence the behavior, motivation, and safety practices of AMTs. Ensuring the safety …

Black Men’S Experiences Of Intergenerational Trauma And Identity Development: A Phenomenological Study, Richard N. Tabb

Doctoral Dissertations and Projects

This qualitative phenomenological study explored how Black men exposed to intergenerational trauma describe their experiences of identity development. Grounded in Vivian Rakoff’s Intergenerational Trauma Theory and William Cross’s Nigrescence Theory, the study employed a transcendental phenomenological design to examine how trauma is transmitted across generations and its implications for Black male identity. This research addresses a critical gap in the mental health field, particularly regarding the historical roots of trauma and their impact on contemporary counseling practices. Findings revealed that the enduring legacy of historical trauma rooted in slavery, systemic racism, and ongoing forms of oppression continues to profoundly shape …

Why Christians Should Read And Write Science Fiction An Examination Of The Benefits Of Using Science Fiction To Spread The Gospel, Matthew Ryan Tompkins

Masters Theses

Science fiction is a form of literature that faces many objections from the church that many people may not be aware. Many Christians assume that science fiction is about worlds and technologies that challenge the nature of God’s creation. This assumption is largely because these opposing Christians have neither read or written science fiction. What this Christian opposition doesn’t realize is that whether it be movies, books or television, science fiction continues to grow in popularity as a genre in mainstream media. This growth has created a unique evangelical opportunity to use science fiction to preach to unbelievers. If Christians …