Digital Commons Network^™

Exploring Inorganic And Organometallic Chemistry, W. Christopher Boyd Phd

MSL Academic Endeavors eBooks

This textbook, Exploring Inorganic and Organometallic Chemistry, covers the fundamentals of inorganic and organometallic chemistry for undergraduate and graduate students. Both theories of structure and bonding and reaction chemistry are covered, with applications to the catalysis of organic reactions, biochemistry, and drug design. A modular approach allows for basic materials of each chapter to be covered in an undergraduate course, with more advanced material suitable for M.S. and Ph.D. students."

Interview No. 1802, Bertha Sierra

Combined Interviews

Bertha Sierra was born in Zacatecas, Mexico, and migrated north first to Ciudad Juárez, then to Los Angeles, and eventually settled in El Paso. In this interview, Bertha tells of her childhood and how life was in the smaller pueblos in Zacatecas and the slow life on the ranch. The first things in life she learned to cook were Frijoles, Tortillas, and Sopa de Fideo, all of which she would cook for her family while her mother was busy tending to the other duties of running a small ranch.  Bertha shares her recipes for Pipián and Carrot Cake in the …

Reproducibility In Modeling Of Knee Joint Mechanics, Maryam Nazem

Electronic Theses and Dissertations

Computational modeling of knee joint biomechanics can provide valuable insights into joint function, injury mechanisms, and patient outcomes, and can support surgical planning and informed clinical decision-making. However, achieving consistent and repeatable results, or reproducibility, is a significant challenge that affects the credibility of these models. This thesis addresses reproducibility through two studies related to the KneeHub Project, which is a multi-institutional collaboration designed to investigate reproducibility in finite-element modeling of the knee.

The first study involved model benchmarking, where predicted results of the calibrated models were compared with the experimental data to evaluate model reproducibility. While all models replicated …

Interview No. 1813, Ruben Montanez

Combined Interviews

The interview was conducted with Ruben Montanez, age 58; he works as a store clerk at Circle K. The interview took place at my grandmother’s house on November 21^st, 2025, and lasted for 17 minutes and 56 seconds. The conversation focused on family tradition and curanderismo, specifically with the tradition of the limpia with an egg, and how this practice has been carried through many generations in the Montanez family. Ruben shared memories of his childhood in Mexico and later, when migrating to El Paso, Texas, with his family. He described his family dynamic as a Catholic household …

Liver-Directed Base Editing Of Abcc6 Prevents Ectopic Calcification In A Variant-Humanized Mouse Model Of Pseudoxanthoma Elasticum, Lauren C. Testa, Dora Obiri-Yeboah, Hooda Said, Ping Qu, Michael A. Levine, Mohamad-Gabriel Alameh, Kiran Musunuru, Qiaoli Li, Xiao Wang

Department of Biochemistry and Molecular Biology Faculty Papers

Pseudoxanthoma elasticum (PXE) is an autosomal recessive connective tissue disorder characterized by ectopic calcification of elastic fibers throughout the skin, retina, and arteries. It is caused by pathogenic variants in ABCC6 , which encodes a transmembrane transporter that primarily localizes to hepatocytes. Loss of ABCC6 function in hepatocytes leads to systemic deficiency of inorganic pyrophosphate (PPi), a potent inhibitor of calcification; such depletion of PPi from the circulation is responsible for multisystemic ectopic calcification seen in PXE. Therefore, liver-targeted variant correction by genome editing and subsequent restoration of systemic PPi may offer a one-and-done therapeutic approach for PXE. The ABCC6 …

Culturally Aware Mindfulness Training For Army Leaders: A Scalable Solution To Strengthen Mental Readiness, Katherine Dutler (Skowronski)

Graduate School of Professional Psychology: Doctoral Papers and Masters Projects

This doctoral paper examines cost-effective, easily distributed mindfulness practices as a force-multiplier for psychological readiness in the U.S. Army. Daily mindfulness reduces symptom burden, raises distress tolerance, and sharpens performance—all without added equipment, appointments, or cost. However, stigma, long waitlists, and civilian-centric messaging still deter soldiers from adapting mindfulness practices. Rather than replacing clinicians, the program functions as preventive maintenance and a bridge while soldiers await care, thereby easing load on an overtaxed system. By embedding mental fitness alongside physical PT, the Army can advance its mandate to “deploy, fight, and win” with forces that are both mentally and physically …

Diras3-Derived Cyclic Peptides Disrupt Kras-Raf Interaction And Kras Nanoclustering, Suppressing Kras-Driven Pancreatic And Ovarian Tumors, Joshua P Gray, Gamze Bildik, Ha-Neul Kim, Margie N Sutton, Jing Wang, Amarachi O Osuji, Nefeli Batistatou, Hailing Yang, Weiqun Mao, Zhi Tan, Geneviève M C Gasmi-Seabrook, Junchen Liu, John F Hancock, Christopher B Marshall, Joshua A Kritzer, Mitsuhiko Ikura, Robert C Bast, Steven W Millward, Zhen Lu

Faculty, Staff and Students Publications

Mutations in KRAS drive 88% of pancreatic ductal adenocarcinomas (PDAC) and up to 40% of low-grade serous ovarian cancers (LGSOC), making KRAS a long-standing therapeutic target. We previously showed that DIRAS3 binds RAS, forming heterodimers that disrupt RAS clustering and downstream MAPK signaling. Building on this, we developed conformationally constrained DIRAS3-derived peptides using two cyclization strategies and characterized them by NMR and biolayer interferometry. These cyclic peptides attenuate the interaction between KRAS and the BRAF RAS-binding domain, penetrate cells efficiently, and inhibit KRAS nanoclustering on the inner leaflet of the plasma membrane. Functionally, they reduce cell viability and suppress PDAC …

Deletion Of Fibro-Adipogenic Progenitors-Specific Follistatin Impairs Muscle Function And Accelerates Skeletal Muscle Atrophy In Obese Mice, Muhammad Rahil Aslam, Muhammad Bilal, Allah Nawaz, Tomonobu Kado, Shinya Abe, Nguyen Quynh Phuong, Memoona, Sana Khalid, Le Duc Anh, Ayumi Nishimura, Yoshiyuki Watanabe, Yoshiko Igarashi, Naeem Iqbal, Maki Yokoyama, Yasuhiro Onogi, Kennichi Hirabayashi, Hiroyuki Miwa, Takumi Era, Martin M Matzuk, Seiji Yamamoto, Koichi Ikuta, Isao Usui, Kohta Kobayashi, Toshihiko Satake, Masaru Kato, Shiho Fujisaka, Kazuyuki Tobe

Faculty, Staff and Students Publications

Background: Follistatin is a potent regulator of various TGF-β superfamily members, including myostatin (MSTN) and activin A. Previous studies have shown that follistatin is crucial in enhancing myogenesis during acute muscle injury. The mechanism by which fibro-adipogenic progenitors (FAPs)-specific follistatin influences muscle homeostasis in obese mice remains unknown. Therefore, we investigated the physiological role of follistatin in PDGFRα-positive FAPs in the regulation of muscle homeostasis and exercise in obese mice.

Methods: A PDGFRα-specific follistatin knockout (follistatin KO) mouse model was generated using PDGFRα-GFP-CreERT2 (PDGFRα-GCE) and follistatinflox/flox mice. These mice were fed a 60% high-fat diet (HFD) for 20 weeks, followed …

The Effect Of Uterine Entry Technique On Chorioamniotic Membrane Separation In Fetoscopic Laser Photocoagulation For Twin-To-Twin Transfusion Syndrome: Protocol For A Randomized Controlled Trial, Brian A Burnett, Jessian L Munoz, Rebecca M Johnson, Christian M Parobek, Luis E Delgadillo Chabolla, Cara Buskmiller, Roopali V Donepudi, Magdalena Sanz Cortes, Michael A Belfort, Ahmed A Nassr

Faculty, Staff and Students Publications

Background: Chorioamniotic membrane separation (CAS) is a recognized complication of fetoscopic laser photocoagulation (FLP) for twin-to-twin transfusion syndrome (TTTS), associated with increased risks of preterm prelabor rupture of membranes (PPROM) and preterm birth (PTB). Although CAS is well described, its incidence and relationship to specific surgical techniques, particularly the method of uterine entry, are not well defined in the published literature. No randomized trials have evaluated whether entry technique influences the risk of CAS.

Methods: We present the protocol for a randomized controlled trial comparing sharp-trocar and Seldinger uterine entry techniques for FLP in TTTS diagnosed between 16 + 0 …

Identifying Compounds To Treat Opiate Use Disorder By Leveraging Multi-Omic Data Integration And Multiple Drug Repurposing Databases, Jeran K Stratford, Megan Ulmer Carnes, Caryn Willis, Melyssa S Minto, Logain Elnimeiry, Ravi Mathur, Matthew Schu, Bryan C Quach, Javan Carter, Tracy Nolen, Nathan Vandergrift, Thomas R Kosten, Eric Otto Johnson, Bradley T Webb

Faculty, Staff and Students Publications

Genes influencing opioid use disorder (OUD) biology have been identified via genome-wide association studies (GWAS), gene expression, and network analyses. These discoveries provide opportunities to identifying existing compounds targeting these genes for drug repurposing studies. However, systematically integrating discovery results and identifying relevant available pharmacotherapies for OUD repurposing studies is challenging. To address this, we've constructed a framework that uses existing results and drug databases to identify candidate pharmacotherapies. For this study, two independent OUD related meta-analyses were used including a GWAS and a differential gene expression (DGE) study of post-mortem human brain. Protein-Protein Interaction (PPI) sub-networks enriched for GWAS …

Alteration Of Gut Microbial Ecology By The Direct Activation Of The Brain: Inverse Gut-Microbiome-Brain Dynamics, I-Ching Wang, Jessica L Swanson, Jillian L Waters, Mikhail Y Kochukov, Shelly A Buffington, Sean W Dooling, Benjamin R Arenkiel, Mauro Costa-Mattioli

Faculty, Staff and Students Publications

The gut-microbiome-brain axis is a bidirectional communication system influencing host physiology and overall fitness. While "bottom-up" effects-where gut microbes influence brain function and behavior-are well established, direct evidence for "top-down" modulation-where the brain shapes the gut microbial ecology-remains elusive. Here, we show that the selective expression of the bacterial ion channel mNaChBac in glutamatergic lateral habenula (LHb) neurons increases their bursting activity and leads to endophentypes associated with depression. Importantly, this chronic activation leads to changes in the gut microbiome composition over time, as reflected by shifts in alpha-diversity and alterations in specific microbial taxa. These findings provide direct evidence …

Multi-Parametric Profiling Of Il-7-Augmented Gd2cart Products In A Phase 1 Clinical Trial, Sarah Schulenberg, Martí Farrera-Sal, Michelle Loeser, Lukas Ehlen, Stephan Schlickeiser, Samira Picht, Lena Peter, Marco Mai, Candise L Tat, Jacqueline Keye, Desiree Kunkel, Frank Lin, Cliona M Rooney, Bilal Omer, Michael Schmueck-Henneresse

Faculty, Staff and Students Publications

CAR T cell (CART) therapy holds promise for cancer treatment, but heterogeneity among products limits clinical effectiveness, making systematic profiling essential to identify predictors of success. Recently, a phase 1 clinical trial investigated whether a constitutively active IL-7 receptor (C7R) could safely improve the function and persistence of GD2-directed CARTs (GD2.CARTs) in pediatric patients with high-grade CNS tumors. We analyzed infusion products from trial participants using a custom-designed 33-color full spectrum flow cytometry (FSFC) panel combined with an image-based tumor killing assay to characterize CART products and evaluate the impact of C7R on GD2.CART performance. Patient-specific variations in T cell …

An Examination Of Disparities In Adhd Diagnosis Between Men And Women, Julia Holloway

University Honors Theses

Attention Deficit Hyperactivity Disorder has become an increasingly popular area of study over the last decade. The rise in cases over the same period likely explains this trend, as does ADHD’s status as one of the most commonly encountered neurodevelopmental disorders. While much of this research has served as an invaluable asset to both practitioners and patients there are still blind spots which have yet to be addressed by the existing body of research. This progress in our understanding of ADHD has gone far in illuminating the biases which have set the precedent for treatment and diagnosis, however, widespread understanding …

Art And Critical Thinking, Audrey Nixon

University Honors Theses

The voice of art molds and dictates norms and behaviors of society. Art eases people into sitting with discomfort or alternate ideas of the world. I work with mixed-media collage to respond and react to culture and the current American political climate. Through the act of expressing and working through thoughts and emotions, art teaches people how to process, it teaches histories of resistance, and empathy. Artists have the ability to engage their audience to critically think about what is happening in our world. By channeling expression and passion, art can help people make necessary connections about concepts that lead …

Between Utterance And Action: The Shaping Of Social Accountability In India’S Coastal Commons, Nayana Udayashankar, Aarthi Sridhar

Journal of Law and Public Policy

Judicial orders, management plans, and zonation maps prepared in relation to environmental laws encode the jurisprudence on accountability. Laws such as India’s Coastal Regulation Zone Notification (CRZ Notification) 2019 serve as sources of discourse on use and access rights. Such laws are crucial in shaping developmental decisions and democratic practice along the coast. As an environmental law that contains detailed articulation on judicially mandated planning, mapping, and public access to regulatory information, the CRZ Notification 2019 offers a good case to understand the relation between legal discourse and citizens’ agency. Citizens of the state of Tamil Nadu representing its small-scale …

Contributors

Regeneración: A Xicanacimiento Studies Journal

Contributor bios of Regeneración v.2.

Re-Membering Self, Rewriting Histories, Reclaiming Futures: Chicanafuturist Agency In V. Castro's The Haunting Of Alejandra, Julia Reade

Regeneración: A Xicanacimiento Studies Journal

Re-membering Self, Rewriting Histories, Reclaiming Futures: Chicanafuturist Agency in V. Castro's The Haunting of Alejandra by Julia Reade.

Journal Of Early Hearing Detection And Intervention: Volume 10 Issue 1, Pages 1-58

Journal of Early Hearing Detection and Intervention

No abstract provided.

Third Grade Reading Proficiency In Deaf/Hard Of Hearing Children Who Received Early Intervention, Jareen Meinzen-Derr, Cassandra Conrad, Mekibib Altaye, Elodie Betances, Jayna Schumacher, Susan Wiley

Journal of Early Hearing Detection and Intervention

Background

Early enrollment in Part C Early Intervention (EI) by age 6 months is linked to improved language and kindergarten readiness in deaf or hard of hearing (DHH) children, but its effect on later academic outcomes is unclear. This study examines whether earlier (<6 months) or later (>6 months) enrollment influences third-grade reading proficiency.

Method

This study used data linked from three Ohio state agencies for infants identified with permanent hearing loss born 2008-2014 who received EI; 412 had third grade standardized reading tests. Reading levels were categorized from limited to advanced. Logistic regression assessed the association between enrollment timing and reading proficiency, …

The Radical Middle: Caregiver Beliefs About Language Access For Deaf And Hard Of Hearing Children, Monica Zmudzinski, Krystal L. Werfel

Journal of Early Hearing Detection and Intervention

The purpose of this study was to explore the communication choices of caregivers of deaf or hard of hearing (DHH) children. Specifically, we explored what communication options caregivers were presented with, identify what factors impacted a caregiver’s decision to pursue spoken language, and identify what barriers exist to learning sign language. We conducted semi-structured interviews with 20 caregivers of DHH children who had decision making power at the time of their child’s diagnosis. Transcripts were coded using an inductive approach with triangulation between authors. Many families reported that minimal to no information was provided about communication options at the time …

Deaf Parents’ Infant-Directed Touch With Their Hearing And Deaf Babies: Intuitive, Cultural, Or In Need Of Instruction?, Brenda C. Seal Ph.D.

Journal of Early Hearing Detection and Intervention

No abstract provided.

Developing A Research Agenda In Partnership With Parents Of Deaf/Hard-Of-Hearing Children, Carrie A. Davenport, Ursula M. Findlen, Ann Schenk Mcalearney, Lisa Vaughn

Journal of Early Hearing Detection and Intervention

Background: Community-based participatory research (CBPR) is an excellent fit for understanding and addressing the unique and diverse needs of deaf or hard-of-hearing (DHH) children and their families.

Objectives: We describe lessons learned from a capacity building project initiating an academic-community partnership between a multidisciplinary research team and a small group of parents of DHH children. Trainings and focus group style discussions created a research agenda reflective of families’ priorities.

Methods: Processes are described related to the development and composition of a Family Advisory Council, training topics and methods, the process for generating and prioritizing topics, and evaluation procedures.

Lessons learned: …

First Report Of A Bat Guano Fire From A Cave In Southeast Asia, Sopark Jantarit, Martin Ellis, Pruet Kalasuwan, Neeranuch Phusunti, Pimonsri Mittraparp-Arthorn, Jiranan Pattano, Arnon Chukamnerd, Turdtun Tong-In, Natthawut Khrueaaunruean

International Journal of Speleology

Fires occurring in cave guano are a rare and unusual phenomenon and the occurrence of such events in Southeast Asia is particularly novel. In this study, we document the first recorded instance of a bat guano fire in a tropical cave at Tham Chao Ram in Sukhothai province, northern Thailand. A bacteriological analysis was made of the guano at the fire site and from a control site within the cave. We give a comprehensive review of global reports on bat guano fires in caves, conduct an initial investigation of the physical factors at the fire site and discuss the potential …

Lessons From Tiktok: Using Popular Social Media Platforms To Engage Gen Z, Debra Bernstein

Urban Library Journal

This study looks at how academic libraries in the New York City metropolitan area are using TikTok to engage with their communities, particularly students. It analyzes the most popular videos from five active library accounts, categorizing content types and measuring engagement through TikTok’s built-in metrics. Results indicate that humorous and lighthearted content consistently receives the highest engagement, while instructional or “how-to” videos tend to underperform. These findings suggest that while TikTok may not be the most effective platform for instructional outreach, it holds potential as a tool for visibility, community engagement, and humanizing the library’s presence. As students increasingly turn …

Development Of Pack-Based Learning Outcome Tests For The Mechanical Engineering Education Study Program Of Teacher Professional Education, Dwi Agus Sudjimat, Darmawan Satyananda

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

This study aims to develop a learning outcome test instrument based on Pedagogical and Content Knowledge (PACK) for students of the Teacher Professional Education Program (PPG) in the Mechanical Engineering Education Study Program (Pendidikan Teknik Mesin, PTM) at Universitas Negeri Malang. The background of this study is based on the need for an assessment that can measure the integration of content knowledge, pedagogy, and technology in accordance with the demands of the Industry 4.0 era. The test development method follows psychometric procedures, including planning, writing, and validating test items, field testing, analyzing test items, and finalizing the instrument. …

Enhancing Recommendation Performance Via Stacking Ensemble And Synthetic Data Augmentation, Zahraa Yaareb Hani, Mohsin Hasan Hussein

Karbala International Journal of Modern Science

Recommendation systems are essential tools that primarily aim to help users navigate through a large volume of information. They simplify the decision-making process by suggesting relevant items based on users’ historical behaviour. However, their performance is often affected by common problems such as data sparsity. This work proposes a stacking-based ensemble recommendation system that integrates multiple machine learning models to enhance the model’s predictive performance. A new synthetic data augmentation technique is introduced to address the sparsity issue in the user–item rating matrix. This method uses the Naïve Bayes algorithm to predict additional ratings for each user. These are then …

The Indiana Statesman, November 20, 2025, Indiana State University

Student Newspaper

Headed to Jeopardy 'Night of Champions.' Who is Harrison Whitaker?; Indiana State Angel Tree donation drive; Campus welcomes Christmas-time Performing Arts Series

November 2025 Academic Affairs Minutes, University Of Nebraska At Kearney Academic Affairs Committee

Academic Affairs Committee Minutes

No abstract provided.

Safety, Security, And… Beavers? An Engineer's Low-Tech Climate Strategy, Matt Mullins

University College: Environmental Policy and Management Capstones

Colorado’s headwaters are the source of drinking water to millions and are a key pillar of the state’s tourism industry. Consequently, they are some of the most vulnerable areas to natural disasters including wildfires, droughts and flooding. Climate change will increase the severity and frequency of these natural disasters. This project focuses on some of the most vulnerable areas from an economic and climate change perspective of Colorado’s headwaters including the Big Thompson River, and the Colorado River. These headwaters located in and around Estes Park, Grand Lake and Rocky Mountain National Park are currently severely impaired. Low-tech process-based restoration …

Incivility Experienced By Males In Nursing Education, Christopher S. Hale

MUSC Theses and Dissertations

Background: Nursing shortages are exacerbated by unhealthy learning environments. Men remain underrepresented among nursing students and faculty, yet their experiences of incivility are rarely examined.

Purpose: Guided by Clark’s Model of Civility in Nursing Education, this dissertation explored how male nursing students and educators in U.S. prelicensure programs experience incivility and how these patterns inform strategies to promote civility and retention.

Methods: This compendium includes (a) an integrative review of nursing faculty mistreatment using Whittemore and Knafl’s method; (b) a cross-sectional survey of male nursing educators and students using the Incivility in Nursing Education–Revised (INE-R) to estimate the prevalence and …