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Volume 13, Number 1, 2023, Volume 13, Number 1, 2023 Nov 2025

Volume 13, Number 1, 2023, Volume 13, Number 1, 2023

Perspectives in the Arts and Humanities Asia

No abstract provided.


Of Retrospection And Reckoning: Appreciating Soledad S. Reyes, D. M. Reyes Nov 2025

Of Retrospection And Reckoning: Appreciating Soledad S. Reyes, D. M. Reyes

Perspectives in the Arts and Humanities Asia

No abstract provided.


Editor’S Introduction, Jonathan O. Chua Nov 2025

Editor’S Introduction, Jonathan O. Chua

Perspectives in the Arts and Humanities Asia

No abstract provided.


Mater Dolorosa Ivatan, John B. Labella Nov 2025

Mater Dolorosa Ivatan, John B. Labella

Perspectives in the Arts and Humanities Asia

No abstract provided.


Balik-Tanaw: The Road Taken, Soledad S. Reyes Nov 2025

Balik-Tanaw: The Road Taken, Soledad S. Reyes

Perspectives in the Arts and Humanities Asia

This paper looks back at my professional career as a teacher and as a critic in the last fifty years. In hindsight, it was intertwined with the specificities of our history and culture. It began in the context of increasing criticism of the dominance of Western writing vis-à-vis Philippine writing, and of the interrogation of the role of literature in a dysfunctional society. The anticolonial thrust shaped the kind of teaching and scholarly activities I engaged in: the study of vernacular literature, women’s writings, Philippine popular culture, and the translation of Tagalog works for a broader readership.


Three Translations, Soledad S. Reyes Nov 2025

Three Translations, Soledad S. Reyes

Perspectives in the Arts and Humanities Asia

No abstract provided.


Tributes, Nikki B. Carsi Cruz Nov 2025

Tributes, Nikki B. Carsi Cruz

Perspectives in the Arts and Humanities Asia

No abstract provided.


Ilang Retrospektibo At Pagpapalawig Sa Kaisipang Reyes Hinggil Sa Aralín At Pagtuturo Ng Kulturang Popular Ngayon, Louie Jon A. Sánchez Nov 2025

Ilang Retrospektibo At Pagpapalawig Sa Kaisipang Reyes Hinggil Sa Aralín At Pagtuturo Ng Kulturang Popular Ngayon, Louie Jon A. Sánchez

Perspectives in the Arts and Humanities Asia

Layon ng sanaysay na ito na maghain ng retrospektibo o, wika nga ni Soledad S. Reyes, “balik-tanaw” sa dalawa niyang sanaysay na matatagpuang pampinid sa Pagbasa ng Panitikan at Kulturang Popular: Piling Sanaysay, 1976–1996 (1997) at sa pinatnugutan niyang teksbuk na Katha (1992) para sa Pamantasang Ateneo de Manila noong dekada 1990. Ang mga ito ay mahalagang pagtatala at pagninilay ng pangunahing iskolar ng kulturang popular sa Filipinas hinggil sa kaniyang mga kaisipan sa aralín at pagtuturo ng kulturang popular. Sa mga akda ring nabanggit, pinahahalagahan niya ang animasyon ng saliksik hinggil sa kulturang popular sa pedagohiya o pagkasangkapan sa …


Phylogenetics Of Cyrtodactylus In West Nusa Tenggara: A New Distribution Record Of Cyrtodactylus Jatnai From Lombok Island And A Cryptic Species From Sumbawa Island, Sandra Rafika Devi, Rury Eprilurahman, Tuty Arisuryanti, Yuliadi Zamroni, Imran Sadewo, Windi Edriyanti, Maulana Faiz Ilham Kholiq, Evelyn Elvira Nov 2025

Phylogenetics Of Cyrtodactylus In West Nusa Tenggara: A New Distribution Record Of Cyrtodactylus Jatnai From Lombok Island And A Cryptic Species From Sumbawa Island, Sandra Rafika Devi, Rury Eprilurahman, Tuty Arisuryanti, Yuliadi Zamroni, Imran Sadewo, Windi Edriyanti, Maulana Faiz Ilham Kholiq, Evelyn Elvira

Turkish Journal of Zoology

Cyrtodactylus is one of the most diverse vertebrates of the Gekkonidae family, first described by Gray in 1827 and widely distributed in Asia, Northern Australia, and the Pacific Islands including Wallacea. The biodiversity in West Nusa Tenggara—a region in Wallacea—has been underestimated despite high fauna endemicity. Conservation strategies are needed to maintain the stability of Cyrtodactylus populations in their habitat. Therefore, this study aims to enhance the understanding of cryptic species and potential new distribution records of the genus Cyrtodactylus in West Nusa Tenggara. Molecular character identification was carried out by isolating the ND2 gene in liver tissue using polymerase …


Bilateral Endogenous Fungal Endophthalmitis Following Elective Surgical Abortion: A Single Center Case Series, Viet Q. Chau, Jesse D. Sengillo, Flavius A. Beca, Julia L. Hudson, Thomas A. Albini, Harry W. Flynn Nov 2025

Bilateral Endogenous Fungal Endophthalmitis Following Elective Surgical Abortion: A Single Center Case Series, Viet Q. Chau, Jesse D. Sengillo, Flavius A. Beca, Julia L. Hudson, Thomas A. Albini, Harry W. Flynn

Wills Eye Hospital Papers

BACKGROUND: To describe the clinical features and management of three cases of bilateral endogenous fungal endophthalmitis following elective surgical abortion performed at the same outpatient surgical center.

METHODS: Case series.

OBSERVATIONS: Three immunocompetent women presented with vision loss days to weeks following elective surgical abortions performed at a single outpatient clinic. Initial visual acuities ranged from 20/20 to 20/300. Fundoscopic examination revealed multiple white round chorioretinal lesions with vitreous infiltration bilaterally in all three patients. Vitreous tap samples were obtained for culture and broad-spectrum intravitreal antimicrobials were administered. Despite negative cultures and systemic workup, the clinical presentation was consistent with …


Ash Sickle Cell Disease Cpkd Guidelines Report, Robert I. Liem, Madeleine Verhovsek, Ted Wun, Sophie Lanzkron Nov 2025

Ash Sickle Cell Disease Cpkd Guidelines Report, Robert I. Liem, Madeleine Verhovsek, Ted Wun, Sophie Lanzkron

Cardeza Foundation for Hematologic Research

No abstract provided.


Exploring The Experiences Of Bahamian Men Diagnosed With Hypertension And Medication Adherence, Bianca Edwards Nov 2025

Exploring The Experiences Of Bahamian Men Diagnosed With Hypertension And Medication Adherence, Bianca Edwards

Walden Dissertations and Doctoral Studies

Hypertension (HTN) is associated with significant health complications, including stroke, myocardial infarction, heart failure, and kidney disease. Despite advances in the treatment and management of HTN, a lack of medication adherence contributes to the persistence of HTN-related morbidity and mortality affecting men in The Bahamas. The purpose of this qualitative descriptive phenomenological study, guided by Pender’s health promotion model and Bandura’s social cognitive theory, was to explore the lived experiences of Bahamian men diagnosed with hypertension regarding their adherence to prescribed medications. Using Giorgi’s descriptive phenomenological method, in-depth, semistructured interviews were conducted with 11 participants. Data were analyzed through repeated …


We Are Not Okay: Narratives Of Black Women Educators Working With Predominantly White Staff, Lindsay Charlotta Bussey Nov 2025

We Are Not Okay: Narratives Of Black Women Educators Working With Predominantly White Staff, Lindsay Charlotta Bussey

LMU Theses and Dissertations

Black women educators (BWEs) who worked in schools with a predominantly White staff endured environments that discouraged them from being themselves, oppressed their natural skill set, and limited their effectiveness. BWEs were not typically recognized for their pedagogical strengths and talents but rather only as racial minority representation in the school. This dissertation study’s two central research questions asked (a) how BWEs perceived the challenges and socio-emotional effects of working in school spaces with predominantly White staff and (b) what conditions were needed to be created for BWEs to heal and feel safe. This research utilized qualitative methods and focused …


Field Validation Of Multiple Species Distribution Models Shows Variation In Performance For Predicting Aedes Albopictus Distributions At The Invasion Edge, Anna V. Shattuck, Brandon D. Hollingsworth Ph.D., Jared Skrotzki, Scott R. Campbell, Christopher L. Romano, Courtney C. Murdock Nov 2025

Field Validation Of Multiple Species Distribution Models Shows Variation In Performance For Predicting Aedes Albopictus Distributions At The Invasion Edge, Anna V. Shattuck, Brandon D. Hollingsworth Ph.D., Jared Skrotzki, Scott R. Campbell, Christopher L. Romano, Courtney C. Murdock

Faculty Publications

Background

Climate and land use changes have resulted in range expansion of many species. In this shifting disease landscape, it is important to leverage tools that can predict the distributions of invading vectors to target surveillance and control efforts and identify at-risk populations. Species distribution models (SDMs) are used to predict ranges of invasive species; however, invasive species often violate assumptions of equilibrium and niche conservatism. Moreover, these studies are rarely validated using independent data.

Methods 

We use long-term surveillance data for Aedes albopictus, a highly invasive mosquito capable of transmitting several arboviruses, at its range edge to evaluate a …


Massachusetts Residents Think Prices Have Increased In Past Year And Will Continue To Rise 11/25/2025, Unh Survey Center Nov 2025

Massachusetts Residents Think Prices Have Increased In Past Year And Will Continue To Rise 11/25/2025, Unh Survey Center

All UNH Survey Center Polls

More than four in five Massachusetts residents believe prices for everyday goods have increased over the past year and more than two-thirds expect them to continue rising over the coming year. Half of state residents believe the overall U.S. economy will experience bad times over the next year and two-thirds believe the economy is getting worse. Bay Staters are also dour concerning their personal finances, as a plurality expect to be worse off financially a year from now and four in five are concerned about winter energy costs. Despite this downbeat outlook, most state residents say that they have enough …


Rhode Islanders Worried About Prices Of Everyday Goods, Winter Energy Costs 11/25/2025, Unh Survey Center Nov 2025

Rhode Islanders Worried About Prices Of Everyday Goods, Winter Energy Costs 11/25/2025, Unh Survey Center

All UNH Survey Center Polls

A majority of Rhode Islanders believe prices have increased on regularly purchased items over the past year and will continue to increase in the coming year. Ahead of the winter heating season, more than three-quarters of state residents are concerned about winter heating costs. Rhode Islanders' assessment of their personal finances remains largely negative but has ticked up slightly since May. Regarding holiday shopping, four in ten Rhode Islanders expect to spend less this year and a quarter feel they don't have enough money to cover their holiday shopping. Rhode Islanders are generally downbeat on the state and national economies, …


Few Connecticut Residents Feel Better Off Financially Than Year Ago Or Expect To Be Better Off A Year From Now 11/25/2025, Unh Survey Center Nov 2025

Few Connecticut Residents Feel Better Off Financially Than Year Ago Or Expect To Be Better Off A Year From Now 11/25/2025, Unh Survey Center

All UNH Survey Center Polls

A majority of Connecticut residents believe prices have increased over the past year and will continue to increase in the coming year. Ahead of the winter heating season, more than three-quarters of state residents are concerned about winter heating costs. State residents' assessment of their personal finances remains largely negative. Regarding holiday shopping, four in ten expect to spend less this year and one-third feel they don't have enough money to cover their holiday shopping. Connecticut residents are generally downbeat on the state and national economies, as a majority feel that the economy is getting worse.


Indigenous Invisibility: Gaps In Education About Indigenous Peoples Among Environmental Decision-Makers, Brittany D. Hunt, Ryan E. Emanuel, David E. Wilkins, Shelly H. Wilkins Nov 2025

Indigenous Invisibility: Gaps In Education About Indigenous Peoples Among Environmental Decision-Makers, Brittany D. Hunt, Ryan E. Emanuel, David E. Wilkins, Shelly H. Wilkins

Jepson School of Leadership Studies articles, book chapters and other publications

Millions of Indigenous people belong to hundreds of Tribal nations and self-determined communities throughout the United States. Many of these groups continue to steward lands and waters that have shaped their distinct cultural and political identities since time immemorial. Increasingly, environmental professionals acknowledge the need to respect, understand, and defer to Indigenous knowledge about Earth's stewardship, but substantial barriers prevent full realization of these goals. One deep-seated barrier is a widespread deficiency in basic education about Indigenous peoples. Education on Indigenous peoples in schools is often fraught with two problems: erasure and stereotypes. Thus, students who pursue environmental careers often …


Bathyal Gastropod (Mollusca) Species From The Turkish Levantine And Aegean Seas, Bi̇lal Öztürk Nov 2025

Bathyal Gastropod (Mollusca) Species From The Turkish Levantine And Aegean Seas, Bi̇lal Öztürk

Turkish Journal of Zoology

This study assigns 35 gastropod specimens and 23 shells collected from two sites on the Turkish Levantine and Aegean coasts at depths of 432 and 702 m, respectively, to 13 species. Among the species identified, Alvania subsoluta (Aradas, 1847), Protatlanta souleyeti (Smith, 1888), Pagodula echinata (Kiener, 1839), Pleurotomella gibbera Bouchet & Warén, 1980, Ringicula gianninii Nordsieck, 1974 and Diaphana marshalli (Sykes, 1904) are new records for the Turkish molluscan fauna; Anatoma aspera (Philippi, 1844) and Acteon monterosatoi Dautzenberg, 1889 are new records for the Levantine coast of Türkiye; and Crenilabium exile (Jeffreys, 1870) is a new record for the Turkish …


Advances In Artificial Intelligence For Glioblastoma Radiotherapy Planning And Treatment, Reid Master, Nesha Rubin, James Sampson, Kamlesh K Yadav, Shruti Pandita, Aria Sabbagh, Anika Krishnan, Patrick J Silva, Kenneth S Ramos, Vincent Gregoire, Nikos Paragios, Sunil Krishnan, Tej K Pandita Nov 2025

Advances In Artificial Intelligence For Glioblastoma Radiotherapy Planning And Treatment, Reid Master, Nesha Rubin, James Sampson, Kamlesh K Yadav, Shruti Pandita, Aria Sabbagh, Anika Krishnan, Patrick J Silva, Kenneth S Ramos, Vincent Gregoire, Nikos Paragios, Sunil Krishnan, Tej K Pandita

The Brown Foundation: Institute of Molecular Medicine

Glioblastoma is an aggressive central nervous system tumor characterized by diffuse infiltration. Despite substantial advances in oncology, survival outcomes have shown little improvement over the past three decades. Radiotherapy remains a cornerstone of treatment; however, it faces several challenges, including considerable inter-observer variability in clinical target volume delineation, dose constraints associated with adjacent organs at risk, and the persistently poor prognosis of affected patients. Recent advances in artificial intelligence, particularly deep learning, have shown promise in automating radiation therapy mapping to improve consistency, accuracy, and efficiency. This narrative review explores current auto segmentation frameworks, dose mapping, and biologically informed radiotherapy …


Nh Economy: Mixed Feelings But Wide Concern About High Prices 11/25/2025, Unh Survey Center Nov 2025

Nh Economy: Mixed Feelings But Wide Concern About High Prices 11/25/2025, Unh Survey Center

All UNH Survey Center Polls

More than three-quarters of Granite Staters say prices on everyday items have increased in the past year and a majority expect that to continue. High energy prices are also a major concern. Only one in five expect good business conditions nationally over the next year and a majority believe the country's economy is on the decline. NH residents are similarly pessimistic about their personal finances, with just over a quarter expecting to be better off in a year. However, Granite Staters' estimates of their holiday spending is higher than in previous years and more than two-thirds say they have enough …


Dating In The Digital Age: The Effects Of Parental Rejection, Rejection Sensitivity, And Self-Esteem Among Gender-Diverse Gen Z, Crystal Currie Nov 2025

Dating In The Digital Age: The Effects Of Parental Rejection, Rejection Sensitivity, And Self-Esteem Among Gender-Diverse Gen Z, Crystal Currie

Walden Dissertations and Doctoral Studies

Gen Z, the first digital-native cohort, faces unique challenges in forming romantic relationships, including heightened dating anxiety. While there is extensive research with previous generations on dating anxiety, self-esteem, and early rejection, no study has examined parental rejection, self-esteem, and dating anxiety collectively, particularly in consideration of gender diverse individuals and digital dating platform use. The purpose of this correlational study was to examine (a) predictors of dating anxiety and (b) whether parental rejection during childhood and rejection sensitivity influenced dating anxiety, as well as the role of self-esteem in mediating those predictor variables. The conceptual framework was the interpersonal …


Targeting The Hepatic Circadian Clock Concomitant With Tyrosine Kinase Inhibition Reverses Late-Stage Hepatocellular Carcinoma, Baharan Fekry, Savera Aggarwal, Rachel Van Drunen, Rafael Bravo, Andy Escalante, Constance Atkins, Sheng Pan, Zheng Chen, Kai Sun, David R Hall, Mamoun Younes, Kristin Eckel-Mahan Nov 2025

Targeting The Hepatic Circadian Clock Concomitant With Tyrosine Kinase Inhibition Reverses Late-Stage Hepatocellular Carcinoma, Baharan Fekry, Savera Aggarwal, Rachel Van Drunen, Rafael Bravo, Andy Escalante, Constance Atkins, Sheng Pan, Zheng Chen, Kai Sun, David R Hall, Mamoun Younes, Kristin Eckel-Mahan

Faculty, Staff and Student Publications

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths. Most patients present at advanced stages, and the effectiveness of tyrosine kinase inhibitors (TKIs) and immune checkpoint inhibitors is constrained by limited patient response. A subset of HCC shows elevated expression of the promoter 2 ("P2")-driven hepatocyte nuclear factor 4 alpha (HNF4α) isoform, which directly transcriptionally represses the circadian brain and muscle ARNT-like protein 1 (BMAL1) transcription factor. This subtype of HCC is robustly inhibited by the plant-based flavonoid nobiletin (NOB), a circadian-fortifying compound. Using patient-matched human HCC and serum, we show that BMAL1-deficient HCC shows exaggerated carnitine palmitoyl transferase …


Patient-Reported Outcomes After Ipsilateral Radiation Therapy For N2b Tonsillar Squamous Cell Carcinoma, Chike O Abana, Adam S Garden, G Brandon Gunn, Gregory M Chronowski, Abdallah S R Mohamed, Andrew J Frankart, Natalie Geier, Houda Bahig, Carly E A Barbon, Kate Hutcheson, Vinita Takiar, Clifton D Fuller, Steven J Frank, David I Rosenthal, Jack Phan Nov 2025

Patient-Reported Outcomes After Ipsilateral Radiation Therapy For N2b Tonsillar Squamous Cell Carcinoma, Chike O Abana, Adam S Garden, G Brandon Gunn, Gregory M Chronowski, Abdallah S R Mohamed, Andrew J Frankart, Natalie Geier, Houda Bahig, Carly E A Barbon, Kate Hutcheson, Vinita Takiar, Clifton D Fuller, Steven J Frank, David I Rosenthal, Jack Phan

Faculty, Staff and Student Publications

Background: Previous studies have reported excellent disease control and survival in patients with well-lateralized, American Joint Committee on Cancer (AJCC)-7 T1-2N2b tonsillar squamous cell carcinoma (SCC). The reduced treatment volume is associated with lower rates of physician-assessed toxicity. Patient-reported outcomes (PROs) have been proposed as a similarly reliable measure, but the body of literature is limited for unilaterally treated patients. Our goal was to review PROs of such patients who had reduced treatment volumes.

Methods: We reviewed PROs of patients with AJCC-7 T1-2N2b disease treated with ipsilateral radiation therapy (RT), with or without surgery or chemotherapy before RT. PROs were …


Coordinated Transfer Of Dna Between Pol Θ And Pol Δ Resets Microhomology Choice During Double-Strand Break Repair, Yuzhen Li, Mark Returan, Adele T Guerin, April M Averill, Dorcas Oladapo, Sylvie Doublié, Richard D Wood Nov 2025

Coordinated Transfer Of Dna Between Pol Θ And Pol Δ Resets Microhomology Choice During Double-Strand Break Repair, Yuzhen Li, Mark Returan, Adele T Guerin, April M Averill, Dorcas Oladapo, Sylvie Doublié, Richard D Wood

Faculty, Staff and Student Publications

DNA polymerase theta (Pol θ)-mediated end joining (TMEJ) initiates DNA double-strand break repair by using short homologies (microhomologies) between single-stranded DNA tails. This repair process is particularly important in cancer cells defective in homologous recombination. The exonuclease function of DNA polymerase delta (Pol δ) has been identified as an essential component for TMEJ, functioning to remove unpaired bases flanking a microhomology (MH). It is not known if the exonuclease removes all unpaired bases at once and how this removal might affect subsequent MH selection. Here, we reconstituted a functional TMEJ repair process using purified human Pol θ and Pol δ. …


Cover And Contents Nov 2025

Cover And Contents

Turkish Journal of Zoology

No abstract provided.


Morphological Variability And Systematics Of Ponto-Caspian Cladocerans Of The Genus Cercopagis Sars, 1897 (Branchiopoda: Onychopoda: Cercopagidae), Larisa F. Litvinchuk, Spartak N. Litvinchuk Nov 2025

Morphological Variability And Systematics Of Ponto-Caspian Cladocerans Of The Genus Cercopagis Sars, 1897 (Branchiopoda: Onychopoda: Cercopagidae), Larisa F. Litvinchuk, Spartak N. Litvinchuk

Turkish Journal of Zoology

In recent decades, significant changes have occurred in the composition of zooplankton, especially in the Ponto-Caspian Basin. An important component of zooplankton in this region is cladocerans of the genus Cercopagis. However, the introduction of invasive species means that many species of this genus have probably become extinct. Because their disappearance molecular study of these organisms is no longer possible. Therefore, a comparative analysis of morphological variability has become more important. We studied the morphological variability of all 12 currently known species of the genus. Samples from the Caspian, Azov, Black, and Baltic Seas were analyzed. The number of species …


The Current Of Anxieties: Ghosts And Capital For The Liminal Bride In Hiroko Oyamada’S The Hole, Maliha Kabir Nov 2025

The Current Of Anxieties: Ghosts And Capital For The Liminal Bride In Hiroko Oyamada’S The Hole, Maliha Kabir

Electronic Theses and Dissertations 2020 - Present

This thesis offers a reading of Hiroko Oyamada’s The Hole as discourse surrounding modern neoliberalism’s dissolution and transformation of boundaries between socio-political domains, such as the public/private, and its consequent effects on individual subjectivity and interpersonal relationships. Within the novella’s depictions of the mundane, I also seek to argue that Oyamada’s employment of the liminal, through distortions of space and time, is used to depict the precarity of marginalization as an always present force due to the pervasiveness of capitalism, but purposefully hidden to maintain security in illusion.


Botulinum Toxin Combined With Robot-Assisted Therapy For Post-Stroke Spasticity: A Systematic Review, Salvatore Facciorusso, Stefania Spina, Mirko Filippetti, Rajiv Reebye, Gerard E Francisco, Andrea Santamato Nov 2025

Botulinum Toxin Combined With Robot-Assisted Therapy For Post-Stroke Spasticity: A Systematic Review, Salvatore Facciorusso, Stefania Spina, Mirko Filippetti, Rajiv Reebye, Gerard E Francisco, Andrea Santamato

Faculty, Staff and Student Publications

Background: Post-stroke spasticity limits motor recovery and independence. Combining botulinum toxin type-A (BoNT-A) injection with intensive, task-specific robot-assisted therapy (RAT) might enhance neuroplasticity and functional gains, but its additive effect and optimal timing are uncertain. (

Methods: We systematically searched major medical databases and trial registries up to April 2025 for randomized controlled trials in adults with post-stroke spasticity comparing botulinum toxin type-A injection plus RAT with toxin injection plus conventional therapy, or RAT alone with RAT combined with toxin injection. Risk of bias was assessed using the RoB 2 tool, and findings were synthesized narratively.

Results: Seven trials ( …


Optimizing Lower Intensity Triplet Therapy In Acute Myeloid Leukemia: A Practical Guide, Wei-Ying Jen, Curtis A Lachowiez, Jennifer Marvin-Peek, Jessica K Altman, Musa Yilmaz, Jacqueline S Garcia, Yasmin Abaza, Nicholas J Short, Joshua F Zeidner, Naval G Daver, Andrew H Wei, Ghayas C Issa, Courtney D Dinardo Nov 2025

Optimizing Lower Intensity Triplet Therapy In Acute Myeloid Leukemia: A Practical Guide, Wei-Ying Jen, Curtis A Lachowiez, Jennifer Marvin-Peek, Jessica K Altman, Musa Yilmaz, Jacqueline S Garcia, Yasmin Abaza, Nicholas J Short, Joshua F Zeidner, Naval G Daver, Andrew H Wei, Ghayas C Issa, Courtney D Dinardo

Faculty, Staff and Student Publications

Venetoclax-based doublets with azacitidine or low dose cytarabine are the standard of care for the treatment of acute myeloid leukemia (AML) in older patients or those unfit for intensive chemotherapy. However, some patients do not attain complete remission, and over time, most patients relapse. Frontline triplet therapy incorporating a targeted therapy (FLT3, IDH or menin inhibitor) is an emerging treatment concept under investigation for this population. Initial triplet regimens have yielded encouraging composite complete remission and measurable residual disease negativity rates, enabling the transition to allogeneic stem cell transplantation for eligible patients. While effective, triplets are associated with myelosuppression and …