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Addressing The Burden Of Prematurity And Its Prevention In Developing Countries: Is It Time To Act Now?, Mahaveer Singh Lakra, Amar Taksande, Revat J. Meshram, Ashwini Lakra, Amit Kumar, Deepak Gandhi, Roshan Prasad, Mayur Wanjari Nov 2025

Addressing The Burden Of Prematurity And Its Prevention In Developing Countries: Is It Time To Act Now?, Mahaveer Singh Lakra, Amar Taksande, Revat J. Meshram, Ashwini Lakra, Amit Kumar, Deepak Gandhi, Roshan Prasad, Mayur Wanjari

Chulalongkorn Medical Journal

Around 3.5 million preterm births occur in India annually, accounting for about 25% of all preterm births worldwide. Prematurity poses a significant burden world-wide but leaves a special impact on the families and health systems of low-socioeconomic countries where easy and universal access to adequate health services is compromised. Premature birth imposes a significant risk of neonatal death among all under-fives due to organ immaturity, sepsis, and respiratory distress syndrome. Efforts to address prematurity on a global scale involve a multifaceted approach, including improving access to quality prenatal care, enhancing neonatal care services, and implementing public health interventions to reduce …


Self-Harm In Indonesian Adolescents And Undergraduates (2015–2025): A Bibliometric And Science-Mapping Study With Guidance And Counseling Implications, Febranti Putri Navion, Wikan Galuh Widyarto, Khilman Rofi' Azmi, Muhammad Sholihuddin Zuhdi, Febri Tri Cahyono, Muchammad Saiful Machfud, Alfan Arifuddin Nov 2025

Self-Harm In Indonesian Adolescents And Undergraduates (2015–2025): A Bibliometric And Science-Mapping Study With Guidance And Counseling Implications, Febranti Putri Navion, Wikan Galuh Widyarto, Khilman Rofi' Azmi, Muhammad Sholihuddin Zuhdi, Febri Tri Cahyono, Muchammad Saiful Machfud, Alfan Arifuddin

Buletin Konseling Inovatif

The objective of this study is to map a decade (2015–2025) of Indonesian research on self-harm among secondary-school students and undergraduates while examining its implications for guidance and counseling practice in schools and universities. The methods applied were a bilingual, population-bounded bibliometric design in which data were retrieved from Google Scholar using Publish or Perish (PoP), screened through a PRISMA-guided protocol, and analyzed with performance indicators such as annual output, sources, top documents, and citation trends, complemented by science-mapping techniques including keyword harmonization and VOSviewer-based co-word networks. The results show that from 440 records initially retrieved, 119 studies met the …


Building Micro-Credential Frameworks: A Strategic Approach For Institutional Success, Justin R. Louder Nov 2025

Building Micro-Credential Frameworks: A Strategic Approach For Institutional Success, Justin R. Louder

TxDLA Journal of Digital Learning

The rise of micro-credentials in higher education presents a transformative opportunity for institutions to deliver flexible, workforce-aligned learning experiences. This article explores key strategies for implementing micro-credential frameworks that align with institutional goals while ensuring quality, scalability, and employer recognition. Drawing from existing models and institutional case studies, the article outlines five critical factors for success: (1) aligning micro-credentials with institutional priorities, (2) conducting market and audience analysis, (3) ensuring academic quality and rigor, (4) leveraging technological infrastructure, and (5) fostering external partnerships. The discussion highlights best practices from leading institutions and offers actionable recommendations for practitioners looking to launch …


The Moderating Effect Of Job Attitudes On Relationship Between Personality Traits And Employees Performance: An Applied Study On Ministry Of Education In Saudi Arabia, Waleed Rashed Alshery Nov 2025

The Moderating Effect Of Job Attitudes On Relationship Between Personality Traits And Employees Performance: An Applied Study On Ministry Of Education In Saudi Arabia, Waleed Rashed Alshery

UB Journal for Humanities

Current study aims to provide empirical evidence regarding the impact of personality traits (extraversion, neuroticism, conscientiousness, agreeable and openness to experience) on the employees' performance. Moreover, the paper is focused on investigating the moderating effect of job attitudes on the relationship between personality traits and employees' performance. The model of the study was developed based on relevant theoretical background. To examine the hypothesized model, the quantitative research design was employed. This study used the systematic sampling. 550 questionnaires were distributed among the employees working in the higher education system of KSA. 325 questionnaires were returned and were usable for analysis. …


Unleash The Potential - Our Vision For East Africa Nov 2025

Unleash The Potential - Our Vision For East Africa

Vision and mission statements

No abstract provided.


Aga Khan University Hospital, Kampala – Overview And Mission Nov 2025

Aga Khan University Hospital, Kampala – Overview And Mission

Vision and mission statements

No abstract provided.


How Not To Go Viral? A Covid-19 Handbook For Students Nov 2025

How Not To Go Viral? A Covid-19 Handbook For Students

University press releases and calendars

No abstract provided.


Relevance And Challenges Of Artificial Intelligence In Nursing Education, Dione Sandiford, Sara Thimmes Nov 2025

Relevance And Challenges Of Artificial Intelligence In Nursing Education, Dione Sandiford, Sara Thimmes

Biennial Convention (CONV)

The integration of artificial intelligence (AI) has become prominent in nursing education. The use of AI in nursing education includes virtual reality, AI-based simulations, virtual patients, and ChatGPT. These various uses of AI in the academic setting provide opportunities for nursing students to develop critical thinking skills, clinical reasoning, decision-making, and clinical judgment. While this may enhance student learning, and revolutionize nursing education and practice, it also presents challenges and risks. The purpose of this poster presentation is to bring to light the importance of AI in nursing education while stressing the risk that must be considered with its use. …


Front Matter, Editors Of Comparative Labor Law & Policy Journal Nov 2025

Front Matter, Editors Of Comparative Labor Law & Policy Journal

Comparative Labor Law & Policy Journal

Volume 45, Number 3


Lost In Translation: Is Data Protection Labour Law Protection?, Michele Molè Nov 2025

Lost In Translation: Is Data Protection Labour Law Protection?, Michele Molè

Comparative Labor Law & Policy Journal

This article critically examines how the European General Data Protection Regulation (GDPR) defines and applies the legal categories of “data subject” and “data controller” within employment relationships. Under the GDPR, employers who collect and process personal data are classified as data controllers, while employees are designated as data subjects. However, this article argues that such a “translation” of data protection categories, rights, and obligations into the regulation of workplace dynamics requires closer examination. The focus is on evaluating whether the GDPR’s rights and obligations for data subjects and data controllers accurately capture the agency and interests of employee and employer …


Unpacking Alpha In Innovation-Driven Etfs: A Comparative Study Of Artificial Intelligence And Blockchain Funds, Davinder K. Malhotra Nov 2025

Unpacking Alpha In Innovation-Driven Etfs: A Comparative Study Of Artificial Intelligence And Blockchain Funds, Davinder K. Malhotra

School of Business Faculty Papers

This paper evaluates the performance and portfolio role of Artificial Intelligence (AI) and Blockchain exchange-traded funds (ETFs) based on monthly returns from 2010 to 2025. The findings show that both AI and Blockchain ETFs generate positive alpha and high standalone returns but also display considerable drawdown risk. Their weak correlations with each other and with broad indices highlight diversification benefits, particularly when combined with U.S. benchmarks. Portfolio optimization reveals that Global Minimum Variance (GMV) and Tangency portfolios ascribe lower weights to these ETFs, while Risk Parity portfolios have a more balanced exposure, helping to diversify risks. Efficient frontier analysis highlights …


Interplay Of Menopause, Coronary Artery Calcium Score And Cardiovascular Disease Risk, Tanisha Mishra, Diksha Sanjana Pasnoor, Murtaza Gandhi, Nida Mohamed, Shaylika Chauhan, Kokou Adompreh-Fia, Kesha Mayank Doshi, Prerana Sevella, Rupak Desai Nov 2025

Interplay Of Menopause, Coronary Artery Calcium Score And Cardiovascular Disease Risk, Tanisha Mishra, Diksha Sanjana Pasnoor, Murtaza Gandhi, Nida Mohamed, Shaylika Chauhan, Kokou Adompreh-Fia, Kesha Mayank Doshi, Prerana Sevella, Rupak Desai

Abington Jefferson Health Papers

BACKGROUND: Postmenopausal women face an increased risk of cardiovascular disease (CVD) due to estrogen withdrawal, which exacerbates traditional cardiovascular risk factors such as dyslipidemia, glucose intolerance, and hypertension. Coronary Artery Calcium Score (CACS), a well-established marker of subclinical atherosclerosis, has emerged as a key predictor of adverse cardiovascular events. Despite the recognized association between menopause and heightened CVD risk, there remains a paucity of literature exploring the specific role of menopause in influencing CACS and its implications for cardiovascular morbidity and mortality.

AIM: To examine the interplay between menopause, CACS, and cardiovascular health by synthesizing existing literature.

METHODS: A comprehensive …


Melanoma Mortality Disparity In Asian American And Pacific Islander (Aapi) Communities In Massachusetts: A Systematic Review And Integrated Policy Analysis, Norman Li Nov 2025

Melanoma Mortality Disparity In Asian American And Pacific Islander (Aapi) Communities In Massachusetts: A Systematic Review And Integrated Policy Analysis, Norman Li

Capstones

Abstract

Objective: This systematic review and integrated policy analysis examines the disproportionately high melanoma mortality rate in Asian American and Pacific Islander (AAPI) populations with a focus on policy analysis, change, and equity in the Commonwealth of Massachusetts. The specific aim is to identify the systemic factors contributing to the late-stage diagnosis of Acral Lentiginous Melanoma (ALM) and to propose feasible, evidence-based policy and practice solutions.

Methods: A systematic literature review was conducted following PRISMA guidelines, utilizing databases including PubMed and CINAHL. The search strategy focused on keywords such as "melanoma mortality," "Asian American and Pacific Islander (AAPI)," "skin of …


Exploring Recruitment Strategies For Place-Based Research In Rural Areas Of Australia: A Comparative Case Study Analysis, Tracy L. Schumacher, Anna K. Jansson, Lucy Kocanda, Jennifer May Phd, Rn, Anp-Bc, Leanne J. Brown, Clare E. Collins Nov 2025

Exploring Recruitment Strategies For Place-Based Research In Rural Areas Of Australia: A Comparative Case Study Analysis, Tracy L. Schumacher, Anna K. Jansson, Lucy Kocanda, Jennifer May Phd, Rn, Anp-Bc, Leanne J. Brown, Clare E. Collins

Publications

BACKGROUND: Recruitment of participants into research studies is commonly challenging and becomes more difficult when targeting underrepresented population groups. Recruiting individuals living in rural locations, must use appropriate strategies if the sample size is to be achieved. The aim of this case study was to explore factors associated with research capacity, and to determine their impact on recruitment strategies, including timeframe and participant recruitment outcomes.

METHODS: This case study investigated the recruitment outcomes of four rurally based research projects performed between 2016-2024. Participants were enrolled either directly by the researchers (face-to-face method [f2f]), or through General Practitioners as trusted local …


Dna Extrusion Size Determines Pathway Choice During Cag Repeat Expansion, Mayuri Bhatia, Ashutosh S. Phadte, Anna Lakhina, Anthony R. Monte Carloi Iii, Sarah Barndt, Anna Pluciennik Nov 2025

Dna Extrusion Size Determines Pathway Choice During Cag Repeat Expansion, Mayuri Bhatia, Ashutosh S. Phadte, Anna Lakhina, Anthony R. Monte Carloi Iii, Sarah Barndt, Anna Pluciennik

Department of Biochemistry and Molecular Biology Faculty Papers

DNA triplet repeat expansion causes several primarly neurological disorders like Huntington's disease, myotonic dystrophy type 1, and fragile-X related disorders. There is general consensus that recognition of extrahelical extrusions or hairpin-loop structures (formed by strand slippage) by the DNA mismatch repair protein MutSβ leads to repeat expansion by a mutagenic process. By contrast, the FAN1 nuclease attenuates triplet repeat expansion, the molecular basis of which was explained by our recent finding that FAN1 nuclease cleaves and initiates removal of extrahelical extrusions. Here we show that extrusions containing two or more triplet repeats are subject to recognition and processing by either …


Economically Optimal Soil Sampling Density And Application Technology For Potassium Fertilizer For Soybean In The Mid-Southern Us, Bayarbat Badarch, Aurelie Poncet, Shelby Ridar, Nathan Slaton, Michael Popp Nov 2025

Economically Optimal Soil Sampling Density And Application Technology For Potassium Fertilizer For Soybean In The Mid-Southern Us, Bayarbat Badarch, Aurelie Poncet, Shelby Ridar, Nathan Slaton, Michael Popp

Agricultural Economics and Agribusiness Faculty Publications and Presentations

To maximize beneficial potassium (K) fertilizer use in irrigated soybean (Glycine max. (L.) Merr.) fields with spatially varying soil-test K (STK), the value of added information from more precise STK maps must be greater than the associated information collection costs. In eleven fields, we modeled the impact of soil sampling densities (SD) ranging from 2.2 samples ha-1 in the largest field (41.2 ha) to 13.59 samples ha-1 in the smallest field (7.4 ha) on STK maps with 0.4 ha grid size. The accuracy of profit-maximizing fertilizer rate prescription maps varied by SD and subsequent yield estimates using either uniform …


Majority In Nh & Southern New England Plan To Eat Turkey For Thanksgiving, One In Six Traveling Outside Of State 11/26/2025, Unh Survey Center Nov 2025

Majority In Nh & Southern New England Plan To Eat Turkey For Thanksgiving, One In Six Traveling Outside Of State 11/26/2025, Unh Survey Center

All UNH Survey Center Polls

A majority of residents of New Hampshire and Southern New England (57%) plan to eat turkey for Thanksgiving this year, 28% plan to watch football, 26% plan to travel somewhere in their state, 25% plan to host friends or family from somewhere else in their state, 17% plan to travel somewhere outside of their state, 12% plan to host friends or family from outside of their state, and 9% do not plan on doing any of these things. Rhode Island residents are most likely to plan to eat turkey and watch football, Massachusetts residents are most likely to travel somewhere …


Experiences Of African Immigrant Nurses Transitioning To The American Healthcare System, Chinomso Nwozichi Nov 2025

Experiences Of African Immigrant Nurses Transitioning To The American Healthcare System, Chinomso Nwozichi

Biennial Convention (CONV)

Introduction: The global nursing shortage has driven a significant migration of African Immigrant nurses (AINs) to the United States. While AINs are essential to the U.S. healthcare workforce, they face considerable challenges, including cultural, professional, and emotional adjustments during their transition.

Methods: This study used a phenomenological approach guided by Ricoeur’s interpretive phenomenology framework to explore the lived experiences of AINs transitioning into the American healthcare system. The study was approved by the Institutional Review Board (IRB) of the primary investigator’s institution. Nineteen AINs working in various U.S. health institutions were selected through purposive sampling and participated in in-depth, unstructured …


Faculty Attitudes Toward Preparing Bsn Students For Practice In Hospital And Non-Hospital Settings, Lisa Victoria Radley Nov 2025

Faculty Attitudes Toward Preparing Bsn Students For Practice In Hospital And Non-Hospital Settings, Lisa Victoria Radley

Biennial Convention (CONV)

The ongoing nursing shortage, worsened in recent years following the COVID-19 pandemic, has resulted in increasing concerns about future deficits in the nursing workforce. Changes in nursing education have been recommended to ensure the next generation of nurses are willing and prepared to meet the needs of an ageing population. Nursing faculty have important roles in the education and mentoring of students to prepare them to care for diverse populations in a variety of practice settings. Understanding faculty attitudes about these changes and whether there are long-held beliefs or ‘sacred cow’ practices that may be challenged is an essential first …


Innovative Nursing Education: Bridging Theory And Practice With Simulation-Based Learning, Malliga Jambulingam, Raquel Bicknell Nov 2025

Innovative Nursing Education: Bridging Theory And Practice With Simulation-Based Learning, Malliga Jambulingam, Raquel Bicknell

Biennial Convention (CONV)

Background: Nursing programs face significant challenges in securing clinical placements for students (American Association of Colleges of Nursing, 2022). Innovative technologies are transforming nursing education by providing realistic, immersive, and flexible learning experiences, bridging the gap between theory and clinical practice. Embracing the latest trends in simulation is crucial for creating an impactful educational environment and encouraging interdisciplinary collaboration (Cheng, 2024).

Objective: This review aims to evaluate recent innovations in simulation-based learning (SBL) in nursing education and their impact on nursing students' knowledge, skills, and confidence. It seeks to identify how innovative technologies are being utilized to overcome clinical placement …


Cover And Conents Nov 2025

Cover And Conents

Turkish Journal of Botany

No abstract provided.


Introduction To Machine Learning And Machine Learning Systems, Raffi T. Khatchadourian Ph.D. Nov 2025

Introduction To Machine Learning And Machine Learning Systems, Raffi T. Khatchadourian Ph.D.

Open Educational Resources

Lecture slides introducing machine learning and machine learning systems for an undergraduate software engineering course. Topics include what machine learning is and how it differs from traditional programming, foundation models, the major types of learning (supervised, unsupervised, reinforcement, and others), and applications across domains. Using a food-delivery time-prediction case study, the deck walks through a typical ML pipeline—data collection and cleaning, feature engineering, model training, and evaluation—and covers evaluation methods (precision and recall, confusion matrices, error measures) along with underfitting versus overfitting and the realities of learning and evaluation in production. Based on "Machine Learning in Production/AI Engineering" by Christian …


Privacy As Professional Identity, Einat Albin Nov 2025

Privacy As Professional Identity, Einat Albin

Comparative Labor Law & Policy Journal

This article explores an important course of action to safeguarding privacy in the workplace, grounded in the professional identity of workers and their corresponding moral and ethical duties towards clients or patients. Described as “privacy as professional identity,” this concept is developed through two key contributions. First, the article argues that workers who are ethically and legally obligated to protect the confidentiality and privacy of their clients or patients — such as psychologists and lawyers — also inherently safeguard their own personal privacy. This argument is substantiated through illustrative examples and anchored in theoretical frameworks concerning the right to privacy. …


Prior Incarceration And Dental Insurance Trajectories Throughout Older Adulthood, A Testa, L Mijares, D B Jackson, V Maroufy, R Samper-Ternent, A C Neumann, R Mungia, K T Ganson, J M Nagata, T Oates Nov 2025

Prior Incarceration And Dental Insurance Trajectories Throughout Older Adulthood, A Testa, L Mijares, D B Jackson, V Maroufy, R Samper-Ternent, A C Neumann, R Mungia, K T Ganson, J M Nagata, T Oates

Faculty, Staff and Student Publications

Objectives: This study examines the relationship between prior incarceration and dental insurance trajectories throughout older adulthood.

Methods: A nationally representative sample of adults aged 55 y and older who participated in the 2012-2020 Health and Retirement Survey was analyzed (n = 6,383). Group-based trajectory modeling was used to identify distinct patterns of dental insurance coverage across the 8 survey waves. Multinomial logistic regression was used to assess the association between prior incarceration and dental insurance trajectory group membership.

Results: Four dental insurance trajectories were identified: persistent dental insurance (30.0%), intermittent high insurance (16.4%), intermittent low insurance (20.4%), and no …


Predicting The Response Of Triple Negative Breast Cancer To Neoadjuvant Systemic Therapy Via Biology-Based Modeling And Habitat Analysis, Casey E Stowers, Chengyue Wu, Clinton Yam, Jingfei Ma, Gaiane M Rauch, Thomas E Yankeelov Nov 2025

Predicting The Response Of Triple Negative Breast Cancer To Neoadjuvant Systemic Therapy Via Biology-Based Modeling And Habitat Analysis, Casey E Stowers, Chengyue Wu, Clinton Yam, Jingfei Ma, Gaiane M Rauch, Thomas E Yankeelov

Faculty, Staff and Student Publications

Despite being the standard-of-care treatment, neoadjuvant therapy (NAT) attains a complete response only in approximately half of the patients with triple negative breast cancer. Thus, methods to predict and optimize patient response to NAT are needed. Previously, we employed patient-specific MRI data to calibrate a biology-based mathematical model that describes cell movement, proliferation, and death due to drug at the tumor level and cell proliferation at an image voxel level. We now extend our approach by using MRI data to group voxels into "habitats" whereby tumor cells of a habitat share the same proliferation. With this approach, we now calibrate …


Impact Of Atrial Fibrillation, Diabetes Mellitus, And Obesity On Outcomes With Aspirin Avoidance And Hemocompatibility With A Left Ventricular Assist Device: An Analysis From The Aries-Hm3 Trial, Nir Uriel, Ivan Netuka, Ulrich P Jorde, Francis D Pagani, Jason N Katz, Jean M Connors, Peter Ivak, Daniel Zimpfer, Yuriy Pya, Jennifer Conway, Finn Gustafsson, Sriram Nathan, Anna Mara Scandroglio, Christopher Hayward, David A D'Alessandro, Morgan Collins, Nicholas Dirckx, Mandeep R Mehra Nov 2025

Impact Of Atrial Fibrillation, Diabetes Mellitus, And Obesity On Outcomes With Aspirin Avoidance And Hemocompatibility With A Left Ventricular Assist Device: An Analysis From The Aries-Hm3 Trial, Nir Uriel, Ivan Netuka, Ulrich P Jorde, Francis D Pagani, Jason N Katz, Jean M Connors, Peter Ivak, Daniel Zimpfer, Yuriy Pya, Jennifer Conway, Finn Gustafsson, Sriram Nathan, Anna Mara Scandroglio, Christopher Hayward, David A D'Alessandro, Morgan Collins, Nicholas Dirckx, Mandeep R Mehra

Faculty, Staff and Student Publications

Background: The ARIES-HM3 trial demonstrated the safety and effectiveness of aspirin elimination from the antithrombotic regimen after HeartMate 3 (HM3) left ventricular assist device (LVAD) implantation. We explored the interaction of atrial fibrillation, diabetes mellitus, and obesity (AF/DM/Ob) with aspirin elimination on hemocompatibility-related adverse events at 1-year postimplant.

Methods: This prospective, double-blind, placebo-controlled trial randomized patients with an HM3 LVAD implant to receive aspirin (100 mg/d) or placebo, in addition to a vitamin K antagonist. The primary endpoint was survival free of nonsurgical (>14 days postimplant) hemocompatibility-related adverse events, including stroke, pump thrombosis, bleeding, and arterial peripheral thromboembolism at …


Taking Small Steps With Big Data: Exploring The Impact Of Education On Social Mobility, Yung Chun, Jenrose Fitzgerald, Jason Jabbari Nov 2025

Taking Small Steps With Big Data: Exploring The Impact Of Education On Social Mobility, Yung Chun, Jenrose Fitzgerald, Jason Jabbari

Center for Social Development Research

Historically, education and workforce-development programs have relied on survey data or state-government administrative data to examine program impacts. However, surveys are costly, reasonable comparison groups can be difficult to identify, and results from analyses of a single state’s administrative data can seldom be generalized to enable broader conclusions. This brief discusses a research collaboration between the Center for Social Development, the National Student Clearinghouse, and a large credit bureau. Through this collaboration researchers used large, frequently updated, multi-type (i.e., “big”) data to examine the impact of education and certificate programs on social mobility, as well as racial and gender equity. …


Phase Equilibria Modeling Constraints On Channel Flow Of Metasedimentary Crust Beneath The Southeastern Tibetan Plateau, Govind Joshi, Gregory Dumond Nov 2025

Phase Equilibria Modeling Constraints On Channel Flow Of Metasedimentary Crust Beneath The Southeastern Tibetan Plateau, Govind Joshi, Gregory Dumond

Geosciences Faculty Publications and Presentations

Lower crust of the southeastern Tibetan Plateau includes 100 s of km2-scale zones of low resistivity at 20-40 km-depths indicating the presence of melt +/- fluid +/- graphite. These zones coincide with interconnected zones of low shear wave velocity. Data from central and southeastern Tibet support the occurrence of meta-sedimentary felsic granulites in the lower crust along a backarc-like geothermal gradient. Phase equilibria modeling of average metasedimentary pelite and greywacke bulk compositions constrained by these geophysical data explored the impact of partial melting on shear wave velocity for a range of fluid content. Low shear wave velocities beneath southeastern Tibet …


An Updated Perspective On Learning, Andrew S. Gibbons Iii Nov 2025

An Updated Perspective On Learning, Andrew S. Gibbons Iii

Faculty Publications

The subject of human learning is revisited. The emergence of new research findings in cognitive neuroscience and related disciplines using new imaging tools and techniques has revealed the existence of not one but two complementary learning systems. A newly-discovered prospection process, interacting with both memory systems, has been revealed as the pivotal mechanism of learning that leads to new experience and new memory records. The universal impact of emotion on this process also receives a new emphasis. This, coupled with the ever-present social environment, show learning to be the result of conversational activity. The existence of this more complete and …


Loss Of Idh1 And Idh2 Mutations During The Evolution Of Metastatic Chondrosarcoma, William Cross, Iben Lyskjær, Christopher Davies, Abigail Bunkum, Ana Maia Rocha, Tom Lesluyes, Fernanda Amary, Roberto Tirabosco, Cristina Naceur-Lombardelli, Mariam Jamal-Hanjani, Charles Swanton, Nischalan Pillay, Simone Zaccaria, Adrienne M Flanagan, Peter Van Loo Nov 2025

Loss Of Idh1 And Idh2 Mutations During The Evolution Of Metastatic Chondrosarcoma, William Cross, Iben Lyskjær, Christopher Davies, Abigail Bunkum, Ana Maia Rocha, Tom Lesluyes, Fernanda Amary, Roberto Tirabosco, Cristina Naceur-Lombardelli, Mariam Jamal-Hanjani, Charles Swanton, Nischalan Pillay, Simone Zaccaria, Adrienne M Flanagan, Peter Van Loo

Faculty, Staff and Student Publications

Driver mutations in IDH1 and IDH2 are initiating events in the evolution of chondrosarcoma and several other cancer types. Here, we present evidence that mutant IDH1 is recurrently lost in metastatic central chondrosarcoma. This may reflect either relaxed positive selection for the mutant IDH1 locus, or negative selection for the hypermethylation phenotype later in tumor evolution. This finding highlights the challenge for therapeutic intervention by mutant IDH1 inhibitors in chondrosarcoma.