Digital Commons Network^™

Long-Term Outcomes And Treatment Patterns In Waldenström Macroglobulinemia Patients Who Discontinue Bruton Tyrosine Kinase Inhibitor (Btki) Therapy, Karan L Chohan, Lorenzo Gensini, Sherif Seif, Xiaowen Sun, Lei Feng, Melody R Becnel, Mahmoud M Gaballa, Hans C Lee, Oren Pasvolsky, Krina K Patel, J Christine Ye, Donna M Weber, Robert Z Orlowski, Sheeba K Thomas

Faculty, Staff and Student Publications

No abstract provided.

Cdk2 Inhibition Enhances Cdk4/6 Inhibitor Antitumor Activity In Comprehensive Breast Cancer Pdx Model Screen, Nealia C House, Maxine M Chen, Sima Khazaei, Victoria Brown, Philip Ramsden, David H Peng, Sydney Moore, Liang Yuan, Rentian Wu, Fangyang Wang, Linjie Luo, Ningping Feng, Christopher A Bristow, Timothy A Yap, Khandan Keyomarsi, Joseph R Marszalek, Scott Ribich, Mikael L Rinne, Lakshmi B Muthuswamy, Kerrie L Faia

Faculty, Staff and Student Publications

Aberrant cyclin-dependent kinase 2 (CDK2) activity is implicated as a resistance mechanism to CDK4/6 inhibitors (CDK4/6i) in hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2-) breast cancer. Using preclinical patient-derived xenograft models, the CDK2i + CDK4/6i combination was active broadly across CDK4/6i-resistant and -naïve HR+ and triple-negative breast cancer models. A novel, weighted mRNA expression signature involving CCND1, CCNE1, RB1, and CDKN2A (p16) predicted response to combined inhibition of CDK2 and CDK4/6. Addition of endocrine therapy significantly enhanced antitumor activity in HR+ models, providing preclinical proof-of-concept for the broad antitumor activity of the triple combination. Early clinical data demonstrated …

His 242 Contemporary European History, Rhiannon L. Dowling

Open Educational Resources

In this course we will be covering European history from the French Revolution to the end of the 20th Century. Students will become familiar with major themes including industrialization, colonization, socialism, nationalism, revolution and world war. They will engage with these topics by listening and responding to lectures, doing various readings, and responding to them in essays and discussion posts. In the process they will develop their critical reading and analytical writing skills and learn to collaborate, revise and refine their ideas as well as their writing.

Unsaturated Fatty Acid Oil-Based Microdroplets: A Promising Novel Class Of Microdroplets, Ramiz S. Alejilat

Seton Hall University Dissertations and Theses (ETDs)

Droplet-based microfluidics has rapidly advanced numerous fields, including chemistry, biology, materials science, medicine, food science, and cosmetics. In these systems, fluorocarbon oil combined with fluorinated surfactants is the preferred medium for fluid encapsulation, offering exceptional stability and biocompatibility essential for sensitive biological and chemical processes. However, growing concerns about the environmental and biological risks associated with fluorinated chemicals have prompted a search for alternatives.

This study is the first to explore the use of unsaturated fatty acids derived from emu oil for microdroplet formation. We characterized droplet formation based on flow rates and the presence non-fluorinated surfactant at a certain …

Fall 2025 Student Scholar Symposium Abstract Volume, Chapman University Center For Undergraduate Excellence

Student Scholar Symposium Abstracts and Posters

No abstract provided.

Bridging Machine Learning And Islamic Scholarship: A Study In Hadith Translation And Similarity Analysis, Asiyah R. Speight

Student Scholar Symposium Abstracts and Posters

Translation of Islamic religious texts poses unique challenges requiring both linguistic and theological expertise. This study explores the application of neural machine translation (NMT) models to Arabic-English hadith translation while analyzing semantic similarity patterns across different human translations. Using the complete Sahih Bukhari corpus (7,550 hadiths) as the primary dataset, we adopt a dual approach combining transfer learning and comprehensive neural network analysis to demonstrate the critical impact of corpus size on model performance.

First, we fine-tune a pre-trained MarianMT Arabic-English translation model on the full Sahih Bukhari corpus, comparing models trained on 40 hadiths versus 7,550 hadiths. Performance is …

2026 Favorite Foods Festival Participation Packet For Rockingham And Strafford Counties, Caitlin Wollack

UNH Cooperative Extension

No abstract provided.

Pathways To Possibility: A Multilingual Perspective In Community Colleges, Alex Matson

Master's Projects and Capstones

Community Colleges (CCs) play a vital role within both their local communities and the broader American educational system. This study examines the role of the community college, with particular attention to its English Speakers of Other Languages (ESOL) programs, and the structural dynamics of public funding. Despite the recognized significance of community colleges, the allocation of public funding, distinctly for ESOL programs, continues to reflect structural imbalances. Although research demonstrates the significance of community colleges in widening learning opportunities for marginalized students, critical pedagogy reminds us that educational access remains structurally unequal.

Emerging research indicates that the transformation of placement …

Interview No. 1800, Allen Rivera

Combined Interviews

Allen Rivera is a retired Military veteran, now working in the I.T. field on Fort Bliss. In this story about the history behind his sleeve tattoos, he goes through many of the stories and meanings behind his tattoos, whether they were dedicated to family members important to him (Grandmother, Aunt, etc.), tributes to major history moments on Puerto Rico (El Morro, Taino artifacts), or they were popular symbols among Puerto Rican culture (Coqui) each tattoo has a meaning and a reason behind the ink. In a mix of personal and cultural, Allen shares different aspects of Puerto Rican culture, such …

Manuscript And Technical Studies, Mary F. Wheaton

University Libraries Faculty and Staff Publications

Extract

Winter’s Middle English Texts Series (MET) published a single volume this year, containing a number of editions of related medieval texts. Hans Sauer and Alessia Bauer’s To Instruct and Entertain – Medieval Didactic Dialogues is the first parallel-text edition of the Old English Prose Solomon and Saturn (SolSatP) edited from London, British Library, MS Cotton Vitellius A.xv and two copies of the Middle English Master of Oxford’s Catechism (MOC), edited from London, British Library, MSS Harley 1304 and Lansdowne 762. In addition to presenting these texts side-by-side, the editors have daringly attempted to construct a …

A Distinct Pp2a Subunit Regulates Local Protein Phosphorylation At The Axon Initial Segment, Andrew P Anderson, Sanghyun Kim, Allison J Melton, Xiaoyun Ding, Wei Zhang, Alexander B Saltzman, Anna Malovannaya, Matthew N Rasband, Yudong Gao

Faculty, Staff and Students Publications

Protein phosphorylation plays a crucial role in regulating the cytoskeletal and membrane proteins at the axon initial segment (AIS). However, our knowledge of AIS-specific kinases and phosphatases is very limited. Here, we report the identification of a protein phosphatase 2A (PP2A) B55 regulatory subunit enriched at the AIS in mice: Ppp2r2c. Our results demonstrate that PP2A-B55 subunits exhibit substantial heterogeneity in their subcellular localization and function. Notably, the Ppp2r2c subunit is selectively concentrated at the AIS, and this enrichment is driven by its unique structure. Utilizing a microelectrode array system (MEA), we show that Ppp2r2c modulates neuronal activity during in …

Medicaid Funding And Health-Related Social Needs: A Policy Analysis, Passion Ilea

Dissertations and Theses

The U.S. has disproportionately high health care spending compared to other high-income nations and comparatively poor health outcomes. The Centers for Medicare and Medicaid Services (CMS) have recently increased emphasis on addressing Medicaid member social needs. CMS believes addressing health-related social needs (HRSN) may reduce costs and improve health outcomes for Medicaid members. CMS has begun to test theories regarding the impact of member HRSN on health care by designing federal mechanisms to address HRSN, such as in lieu of services and settings-funded services, and by encouraging state Medicaid programs to develop their own approaches, such as Flexible Services. Information …

Investigating Dysfunctional Cognition Change As A Putative Mechanism Of Cbt For Youth Anxiety, Ocd And Ptsd: Protocol For An Individual Participant Data Meta-Analysis, Ivana Buric, Anke Klein, Ronald M Rapee, Brooke Levis, Philip C Kendall, Eric A Storch, Lynn Mobach

Faculty, Staff and Students Publications

Introduction: Anxiety disorders, obsessive-compulsive disorder (OCD) and post-traumatic stress disorder (PTSD) are common in children and adolescents and can lead to significant impairment. Cognitive behavioural therapy (CBT) with exposure is the first-line treatment, yet approximately half of treated youth do not achieve full remission. Dysfunctional cognitions-negative automatic thoughts, maladaptive beliefs and distorted interpretations-are considered key targets of CBT, but evidence in youth is mixed and underpowered. This study will examine whether change in dysfunctional cognitions mediates treatment outcome in anxiety, OCD and PTSD symptoms and whether this association varies across individual characteristics.

Methods and analysis: An individual participant data meta-analysis …

Restoration Of Sfrp3 Preserves The Neural Stem Cell Pool And Spatial Discrimination Ability In A Mouse Model Of Alzheimer's Disease, Chia-Hsuan Fu, Jin Park, Umberto Tosi, Francisco A Blanco, Manuel Silva-Pérez, Kavitha Muralidharan, Jason C You, Minjung Lee, Gabriel S Stephens, Xiaohong Zhang, Yi Zheng, Helen Scharfman, Kimberley F Tolias, Jeannie Chin

Faculty, Staff and Students Publications

Individuals with Alzheimer's disease (AD) have an increased incidence of seizures, which worsen cognitive decline. Using a transgenic mouse model of AD neuropathology that exhibits spontaneous seizures, we previously found that seizure activity stimulates and accelerates depletion of the hippocampal neural stem cell (NSC) pool, which was associated with deficits in neurogenesis-dependent spatial discrimination. However, the precise molecular mechanisms that drive seizure-induced activation and depletion of NSCs are unclear. Here, using mice of both sexes, we performed RNA-sequencing on the hippocampal dentate gyrus and identified differentially expressed regulators of neurogenesis in the Wnt signaling pathway that regulates many aspects of …

The Perspectives And Experiences Of Prospective Parents Declining Diagnostic Prenatal Genome Sequencing In Continuing Pregnancies With Fetal Structural Anomalies, Lisa S Weingarten, Allison Rosenbaum, Jessica De Voest, Stephanie Galloway, Jessica L Giordano, Samantha Stover, Lauren E Westerfield, Grant Bonesteele, Kelly L Gilmore, Leandra Tolusso, Beatrix Wong, A Theresa Wittman, Daniel T Swarr, Nancy Leslie, Anthony Johnson, Ignatia B Van Den Veyver, Neeta L Vora, Rebecca G Clifton, Aaron B Caughey, Ronald J Wapner, Wendy K Chung

Duncan NRI Faculty and Staff Publications

Objective: This study evaluates an understudied perspective: the experiences of prospective parents who decline prenatal genome sequencing (pGS) for continuing pregnancies with fetal structural anomalies.

Method: We recruited a total cohort of 300 parents of 150 pregnancies who declined pGS, including 33 individuals who underwent an invasive procedure. These parents were invited to participate in a semi-structured interview between 1 and 15 months post-partum. We used Thematic Analysis to code and analyze interviews.

Results: We interviewed 22 parents of 16 pregnancies. Reasons for declining testing included risks of invasive procedures (n = 19, 86%), lack of prenatally actionable findings (n …

Unconventional Binding Of Calmodulin To Chk2 Kinase Inhibits Catalytic Activity, Christopher R Horne, Tingting Wang, Samuel N Young, Toby A Dite, Hunter G Nyvall, Sushant Suresh, Katherine A Davies, Abner Gonzalez Castro, Vineet Vaibhav, Lucy J Mather, Laura F Dagley, Matthew J Belousoff, Gerard Manning, Anthony R Means, John E Burke, Janni Petersen, John W Scott, James M Murphy

Faculty, Staff and Students Publications

Calmodulin (CaM) serves an essential role in eukaryotic cells as a Ca2+ sensor. Ca2+ binding leads to conformation changes in CaM that enable engagement of a repertoire of enzymes and the regulation of their catalytic activities. Classically, Ca2+-CaM binds to an inhibitory pseudosubstrate sequence C-terminal to the kinase domain in members of the Ca2+-CaM-dependent protein kinase (CAMK) family and relieves inhibition to promote catalytic activity. Here, we report an unexpected mechanism by which CaM can bind CHK2 kinase to inhibit its kinase activity. Using biochemical, biophysical and structural mass spectrometry, we identify a direct interaction of Ca2+-CaM with the CHK2 …

Experience From A Distance: Improving Transparency For The Multnomah Athletic Club, Matthew Penner

University Honors Theses

Portland is home to the largest and one of the most prestigious athletic clubs in the world: Multnomah Athletic Club. In many ways, it is the pinnacle of luxury and innovation, and over time, it finds any way to entice prospective members to pay the expensive upfront fee of $6000 and monthly membership fees exceeding $300. Due to the previous technological barrier, which was not being able to see the full extent of what amenities the club had to offer, the club faced major challenges in recruitment and marketing. Over two academic terms, a team of six computer science capstone …

Technology Use In Elementary Music Education: A Scoping Review, David T. Casali

Journal of the Association for Technology in Music Instruction

The purpose of this scoping review was to look at how music technology has been used in the elementary music classroom from 2020 to April 2025. Uses of technology were organized using the Substitution, Augmentation, Modification, and Redefinition (SAMR) model (Puentedura, 2006). Only articles that both described how technology was used and what the learning process looked like were included. A total of 26 articles met the criteria for inclusion. Multiple uses of technology across the four levels of the SAMR were represented from 14 different countries. An article from each of the four SAMR levels is described in depth …

From Function To Culture: Exploring Senior-Centered Design Principles In Korean Context, Sujin Song, Miso Kim, Min Ju Kang, Ye In An, Soojin Jun

IASDR Conference Series

South Korea, as the fastest-aging country in the world, occupies a critical position in aging research. Designing for older adults requires a multidimensional understanding; however, existing studies on design principles for aging have tended to adopt functionalist approaches focused primarily on physical and cognitive decline. In response, this study proposes design principles that center on values systems rather than offering directly prescriptive or procedural guidance. Specifically, we introduce culturally responsive principles grounded in Korea’s unique socio cultural context. Drawing on a co-design workshop with Korean older adults and caregivers, our analysis engages narratives through the lenses of Korea’s rapid industrialization, …

Designing Personalized Digital Self-Control Tools To Address Procrastination Through Co-Design, Youngsoo Shin, Jeremy D. Faulk, Jungkyoon Yoon

IASDR Conference Series

Procrastination, a pervasive challenge among college students, significantly affects mental health, academic performance, and overall well-being. While Digital Self-Control Tools (DSCTs) are commonly used to manage procrastination, existing solutions and studies often fail to address the nuanced, individualized factors that drive this behavior. This study employs a co-design approach to explore how DSCTs can be personalized to better support college students. Over a nine-week co-design project, twenty-two students in the HCI field collaboratively developed personalized DSCT concepts, guided by the Motivation, Engagement, and Thriving in User Experience (METUX) model. The METUX model provided a theoretical basis for designing interventions that …

Strategies To Foster A Collaborative And Sustainable Transformation: A Vietnam Textile & Apparel Case, Hong Lan Lam, Donna Cleveland

IASDR Conference Series

This case study explores strategies to support the transformation of Vietnam’s textile and apparel industry, particularly large garment exporting enterprises, toward more sustainable and designed-led business models. In response to increasing socio-economic and environmental challenges, the study identifies closer collaboration with academic institutions as a key enabler for building relevant future- facing skills. Drawing on reflexive practice through structured journal writing, the paper analyses a multi-stakeholder workshop facilitated by the International Labour Organization and the Vietnam Textile and Apparel Association (VITAS), highlighting tensions and opportunities in co-design approaches within hierarchical and culturally specific working environments. The concept of đồng- design, …

Process Designing For Creative Well-Being: How Cultural Prescribing Emerges Through Community-Based Art Practice At Machino Zukoushitsu In Nabari City, Japan, Rui Fukumoto, Takakazu Yamaguchi, Hideaki Kawabata, Sawako Inaniwa, Tatsuya Ito

IASDR Conference Series

As societies around the world confront aging populations and growing social isolation, Cultural Prescribing has emerged as a promising approach to community-based care beyond institutional systems. While social prescribing has primarily been implemented through clinical referral models, this study examines how Naturally Emergent Creative Well-being, the interaction between individual creativity and community culture, can generate care organically through everyday practice. The research focuses on Machino Zuko ushitsu, a community art studio in Nabari City, Japan, which serves as a hub for creative participation, intergenerational exchange, and informal support. Using a participatory action research framework, qualitative data were collected through interventional …

A Study On The Current Status Of Technology Application And Learning Models In Senior Citizens' Participation In Ceramic Craft Experience Activities, Tien-Li Chen, Ting-Yu Hsu, Rui Zhu

IASDR Conference Series

Global population aging has brought increasing attention to the quality of later life and physical and mental health. Relevant studies have shown that craft-based art activities can enhance well-being and fine motor skills, and provide older adults with a means of non-verbal communication. In addition, as technology has become integrated into daily life, its impact on elderly learning has also drawn interest. This study aims to explore the actual situations and effects of technology use during older adults’ participation in ceramic craft experience activities, further understanding how elderly learners access learning resources, their level of acceptance toward technological tools, and …

Co-Creating Futures Of Communication: Three-Phase Speculative Co-Design With Adults Of The One-Child Generation, Ines Ziyou Yin, Xinjun Miao, Yirong Jiang, Yijun Yin, Kin Wai Michael Siu

IASDR Conference Series

Traditional linear models of human communication inadequately address emotional and social dynamics in everyday contexts. This study explores speculative futures of interpersonal communication through research through design (RtD) paradigm, integrating participatory co-creation, speculative design, role-playing, and Generative Artificial Intelligence (GenAI). Situated within the socio-cultural context of China’s one-child generation in the Greater Bay Area (GBA), the research transcends linear transmission metaphors in existing information communication technologies (ICTs) to address subtle interpersonal needs among friends. The study adopts a three-phase methodology, including a co-design workshop to generate speculative scenarios, designer-AI collaboration to refine scenarios, and a role- playing session to generate …

The X_Heal Toolkit: Navigating Temporal And Dynamic Self-Healing Processes In Living Materials, Verindi Vekemans, Stefano Parisi, Fanzhe Zeng, Jun Wu, Elvin Karana

IASDR Conference Series

Self-healing, a remarkable ability of living organisms, is gaining attention in biodesign as a pathway toward sustainability. Applications range from fungi-based repair in packaging to bacterial healing in soft robotics. The expressive, dynamic, and temporal nature of self-healing offers rich design opportunities but also presents challenges due to emergent behaviours and environmental dependencies. Healing may unfold gradually, leave visible traces, or transform material in unpredictable ways, making it difficult to observe, describe, and communicate through existing design tools. This paper introduces a toolkit, namely the X_Heal Toolkit, that enables designers to analyse and characterise self-healing processes. Grounded in frameworks of …

Cultural Manifestations Of Sketch Inhibition In East Asian Design Education: A Grounded Theory Approach, Zhenyu Ma, Wei Man

IASDR Conference Series

This study investigates the phenomenon of sketch inhibition in East Asian design education contexts through a grounded theory approach, exploring how cultural, institutional, and technological factors shape students' utilization of sketching as a design thinking tool. Through systematic analysis of in- depth interviews with 41 participants from China, Japan, and cross-cultural backgrounds—including design educators (n=11), industry experts (n=12), and students (n=18)—this research reveals unique manifestations of sketch inhibition distinct from Western contexts. The study employs rigorous open, axial, and selective coding procedures to construct a theoretical framework capturing the multidimensional nature of sketch inhibition in East Asia. Key findings indicate …

Ride Comfort Analysis Of Disaster-Resistant Bicycles Based On Vibration Characteristics, Ryotaro Nagata, Minami Tanaka

IASDR Conference Series

This study examines the influence of handlebar geometry on the vibration characteristics of disaster- resistant bicycles equipped with puncture-resistant tires, which are known to increase vibration and reduce comfort. Three handlebar types—straight, riser, and bullhorn—were evaluated through impulse hammer excitation and acceleration data analysis under controlled conditions. The results showed clear differences in vibration transmission depending on handlebar shape. Notably, the bullhorn handlebar exhibited superior vibration dispersion and lower peak acceleration values compared to the straight and riser types. These findings indicate that handlebar geometry significantly affects vibration characteristics; however, further investigation is required to directly assess improvements in ride …

Cultivating Critical Design Agency Through Serious Game Design: Integrating Systems Thinking And Design Thinking, Yen-Fu Chen, Chu-Chi Weng, Tung-Yi Cheng

IASDR Conference Series

This study explores how integrating Design-Based Learning (DBL), systems thinking, and design thinking within a serious game design curriculum fosters socially responsible design literacy in undergraduate students. Implemented over four academic years at a media design program, the two-semester course sequence guided over 280 students to design both analog and 2D digital games addressing real-world challenges aligned with the UN Sustainable Development Goals (SDGs). The curriculum combined iterative project work with empathy-driven field research, stakeholder analysis, systems mapping, prototyping, and structured peer feedback. Students engaged in translating complex social issues into playable narratives and interaction systems. Data sources included student …

Ageism, Loneliness, And The Built Environment: Shaping Older Women's Play In Public Housing Estates, Yi Izzy Jian, Tian Cheng, Wei Xuan Chen, Ka Him Mo

IASDR Conference Series

Play in later life is more than leisure—it is an act of autonomy, resistance, and identity negotiation, especially for older women navigating marginal ity in public housing. Yet, conventional urban design and social programming often fail to recognize its significance. This study investigates how play is interpreted and practiced by 39 female older adults, using semi-structured interviews and network analysis. Findings indicate that socially-driven, self-organized activities such as chatting and volunteering form the core of meaningful play, while procedural barriers and spatial limitations hinder participation in more structured, passive forms. Ageism, loneliness, and dissatisfaction with the built environment further restrict …

Toward Robot-Driven Elderly Care Home Services And Systems In Hong Kong: An Ecosystem Perspective, Sanqi Yang, Jaehyun Park, Ting Han

IASDR Conference Series

In previous studies, researchers have highlighted the potential of robots and gerontechnologies to address the current caregiver shortage and enhance elderly care home services and systems. Yet most established robot-driven elderly care services and systems often fail to deliver value in actual service environments. Therefore, our study explores design features of robot-driven elderly care home services and systems from a service ecosystem perspective. To address this, we adopted an ecosystem theory incorporating economic, environmental, cultural, and social systems, and conducted multiple field observations in four care homes in Hong Kong. Surprisingly, we found most robot services and systems were overlooked …