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Development Of Photolabile Coumarin Linker For Rna Synthesis And Crisprcas9 Applications, Ian Mcclain

Electronic Theses & Dissertations (2024 - present)

The scope of RNA-based therapeutics continues to expand as more siRNA, mRNA, and CRISPR-based treatments are approved for various medical applications. Purification of synthetic RNA drugs is inherently challenging and requires considerable time and resources. New cost-effective and efficient purification strategies will expedite drug development process and will lower the drug costs. In this thesis I describe two generations of photolabile linkers for the non-chromatographic purification of therapeutic RNAs. In addition, the photolabile linker was utilized for regulation CRISPR-Cas9 gene editing. In the first part of the thesis, I describe the first generation of the photolabile coumarin-based linker for non-chromatographic …

Building Fiscal Resilience And Enhancing Social Equity In Disaster Mitigation At The Local Level, Hyoeun Kim

Electronic Theses & Dissertations (2024 - present)

As climate-related disasters are becoming more frequent and severe, local governments face growing pressure to manage disaster-related fiscal shocks. Although disaster mitigation and preparedness are widely recognized as cost-effective strategies for reducing future losses, local governments often lack the financial, political, and technical capacity to invest in them. Despite the importance of pre-disaster investment, mitigation and preparedness efforts continue to lag at the local level, and concerns remain that federal mitigation funding is not distributed equitably across communities. This has important implications for both equity and resilience because unequal access to mitigation resources can reinforce existing vulnerability to future natural …

Three Essays In Labor Economics, Yoritsugu Shimazu

Electronic Theses & Dissertations (2024 - present)

The first chapter decomposes aggregate productivity growth into a pure-technology contribution and an allocative-efficiency contribution for Japan and the United States, applying a single estimation methodology symmetrically to comparable firm-level panels. Production functions are estimated by the Gandhi, Navarro, and Rivers (2020) gross-output procedure under monopolistic competition (GNR-MC), which recovers firm-level price markups and wage markdowns, and these enter the Baqaee–Farhi (2020) decomposition through the closed form of Aoki et al. (2024). Both panels are drawn from Compustat with identical pre-processing and estimation, and we close the markup-level identification gap that GNR leave open with a normalization anchored on the …

The Communicative Constitution Of Resilience In Graduate-Student Parenthood: Ventriloqual Analysis, Intersectionality, And Sociomaterial Assemblages, Lin Lin

Electronic Theses & Dissertations (2024 - present)

Graduate education is often organized around norms of uninterrupted productivity, flexibility, and professional availability, making graduate study especially challenging for students who are simultaneously raising children. Although prior research has documented the structural barriers faced by graduate student parents (GSPs), less attention has been paid to how resilience is communicatively enacted within the intersection of academic work and family life. This dissertation examines how GSPs communicatively constitute resilience while navigating work-life disruptions. Drawing on Communication Theory of Resilience (CTR) and the communicative constitution of organizations (CCO) perspective, particularly ventriloqual analysis, this study explores how resilience emerges through interactions among human …

Perceptions Of Psilocybin-Assisted Psychotherapy And Standard Interventions For Nicotine Cessation, Philip Kamilar-Britt

Electronic Theses & Dissertations (2024 - present)

Clinical trials suggest potential therapeutic utility of psilocybin-assisted psychotherapy (PAP) for nicotine cessation. In response to promising outcomes, research into PAP for nicotine dependence is growing. However, attitudes towards PAP among the general public, especially daily nicotine users, remains understudied. To address this knowledge gap, we recruited daily nicotine users (N=534) to complete an anonymous online survey with questions on demographics, nicotine use, prior history with psychedelics, and attitudes towards PAP and standard interventions for nicotine cessation. As hypothesized, daily nicotine users were more familiar with standard interventions and rated them more favorably than PAP. Despite differences in treatment attitudes, …

When Helpfulness Becomes Harmful: Jailbreaking Llms For Malicious Code Generation, Noelle Capodieci

Electronic Theses & Dissertations (2024 - present)

Generative AI (GenAI) and Large Language Models (LLMs) have made large strides in coding task capabilities, with many software developers integrating agentic engineering into their workflow. While GenAI has largely benefited professional software engineers who can automate their work, it has also created room for those with little coding expertise to also create fully fledged programs and applications. It is commonly noted that GenAI is trained with two major goals in mind: to be as helpful as possible, and be as harmless as possible. There exist moments where helpfulness may be prioritized over harmlessness when these goals conflict. LLMs may …

Specification Of Validated Groundwater Flow And Transport Models For Historical Perfluorinated Compound Dose Reconstruction, Cindy A. Arthur

Electronic Theses & Dissertations (2024 - present)

Per- and polyfluoroalkyl substance (PFAS) contamination in Hoosick Falls, New York, resulted from historical industrial activities, with groundwater transport identified as the primary pathway impacting the municipal wellfield within the Village of Hoosick Falls, whereas atmospheric deposition remains a potential source of private well contamination. This study employed two complementary methodologies to evaluate historical municipal and private well contamination: (i) groundwater flow and transport modeling of PFOA, PFOS, PFHxS, and PFNA within the village, and (ii) Geographic Information Systems (GIS)–based inverse distance weighting (IDW) interpolation of PFOA concentrations in private wells across the broader Town of Hoosick.

Groundwater modeling results …

The Effects Of Downdraft And Radial Ventilation In Hurricanes Earl (2010) And Edouard (2014), Jacob Vile

Electronic Theses & Dissertations (2024 - present)

Tropical cyclone (TC) intensity change in moderate vertical wind shear (VWS) is difficult to predict. Specifically, ventilation, the intrusion of dry and/or cool (i.e., low equivalent potential temperature (theta-e) air inside the TC, can have differing effects on TCs. Downdraft ventilation is the downward transport of below-mean  theta-e air by downdrafts, and radial ventilation is the inward transport of below-mean theta-e air by storm-relative radial winds. If this low theta-e air is able to get ingested by updrafts, it can result in a reduction of convection in the TC, thereby reducing intensity. Although most studies of ventilation have been conducted …

Key Processes Involved In The Vortex Alignment Of Sheared Tropical Cyclones, Luis O. Hernandez

Electronic Theses & Dissertations (2024 - present)

Tropical cyclones (TCs) are challenging to forecast when under vertical wind shear (VWS). VWS tilts a TC’s vortex, creating asymmetries in its structure that impedes intensification. Although work has been done to conceptualize and understand how TCs evolve under shear and how they axisymmetrize and intensify, vortex alignment remains a complex and unresolved topic. The goal of this study is to assess what physical processes are important to tilt reduction and how these processes evolve in weak TCs. Using the Hurricane Analysis Forecast System Model-B (HAFS-B) 2.1, a case study on two storms, Hurricane Earl (2022) and Hurricane Lee (2023) …

An Evaluation Of Current And Future Extreme Precipitation Events In The South American Altiplano Using Convective-Permitting Model Simulations, Karen R. Conron Chamberlain

Electronic Theses & Dissertations (2024 - present)

Extreme precipitation events in the South American Altiplano present significant hazards to communities in the Andean region, yet their future characteristics under anthropogenic climate change remain uncertain because of complex terrain and limitations of course-resolution climate models. This study evaluates the ability of South America Affinity Group Weather Research and Forecasting (SAAG-WRF) model with 4-km grid-spacing to reproduce 2000-2015 temperature, precipitation, and extreme precipitation events over the Altiplano. Examination of projected future changes is completed using the SAAG-WRF pseudo global warming (WRF PGW) simulation representing an approximately 3°C warmer global climate. The historical/control simulation (WRF CTL) was evaluated against DECADE …

Combating Antibiotic Resistance With Plasmid-Dependent Phages, Rhiannon T. Mariano

Electronic Theses & Dissertations (2024 - present)

The alarming rise of carbapenem-resistant bacteria poses an urgent global health threat, driven in large part by the horizontal spread of carbapenemase-encoding plasmids (Ma et al., 2023). These plasmids are often highly mobile and transmissible, enabling rapid dissemination of resistance genes across diverse bacterial populations. Their mobility is largely mediated by conjugation, a process dependent on the formation of pili, which serve as physical bridges for plasmid transfer between cells (Murray et al. 2022; San Millan and MacLean 2017; Virolle et al. 2020). Beyond their role in gene exchange, these pili also act as entry points for a unique class …

From Written Curriculum To Classroom Practice: Teacher Supplementation In The Teaching Of American Slavery In Florida And New York, Matthew T. Maloof

Electronic Theses & Dissertations (2024 - present)

This study examined how K–12 public school teachers in Florida and New York perceived the adequacy of curriculum standards and instructional materials for teaching American slavery, how they responded when those materials were perceived as limited, and how the standards and materials aligned with Shuster’s (2018) Ten Key Concepts for Teaching American slavery. Using a qualitative multi-method design, the study combined qualitative survey research with document analysis. Teachers’ open-ended survey responses were analyzed through a Modified Grounded Theory approach, while curriculum standards and instructional materials were analyzed in relation to Shuster’s framework. The final sample included 41 teachers, including 20 …

Essays On Nursing Home Closures And Disparities In Post-Acute And Long-Term Care, Hyeonwoo Do

Electronic Theses & Dissertations (2024 - present)

This dissertation examines the consequences of nursing home closures for access to care, local economic conditions, and resident health in the United States. As the long-term care system shifts toward home- and community-based services and the nursing home sector contracts, facility closures have become an increasingly important policy concern. Although closures may reflect necessary market restructuring in some settings, they may also reduce access, weaken local economies, and place pressure on surviving facilities. Across three essays, this dissertation shows that the consequences of nursing home contraction are uneven and depend on racial and ethnic composition, rurality, local market concentration, and …

Cognate Awareness Training For Novice L2 Learners: Orthographic And Phonological Routes To Vocabulary Learning, Jennifer M. Martin

Electronic Theses & Dissertations (2024 - present)

Within the study of cross-linguistic influence, research on cognate facilitation has consistently shown that proficient bilinguals process cognates (e.g., English “sock” and German “Socke”) more efficiently than non-cognates. However, less is known about how novice adult learners may benefit from these similarities during the earliest stages of second language acquisition or how instructional interventions might facilitate this process. This dissertation addressed this gap through experiments with English-speaking adults learning German. A series of experiments examined the effects of cross-linguistic similarity and explicit cognate awareness training on vocabulary acquisition. Experiment 1A found robust similarity effects in written recall and …

Psychometric Assessment Of The Facilitative Systemic Intervention Skills Rating System– Spanish Version, Sarah J. Crosky

Electronic Theses & Dissertations (2024 - present)

Despite the growing understanding of therapist factors in client outcomes, there remains limited understanding of the skills that distinguish effective family therapists. The aim of the present study was to assess the interrater reliabilities and factorial structure of a Spanish version of the Facilitative Systemic Intervention Skills (FSIS; Jones et al., 2023a), an observational rating system for evaluating the skillfulness of family therapists in delivering systemic interventions. The FSIS includes eight empirically and theoretically informed systemic therapy skills (Inclusiveness, Empathy for Relational Difficulties, Responsiveness to Safety Concerns, Collaborative Stance, Conceptualizing Family Problems Systemically, Responsiveness to Disparate Goals, Focus on Family …

On Quantum Processes And The Epistemic Constraints, Varun Immanuel Premkumar Immanuel

Electronic Theses & Dissertations (2024 - present)

This doctoral dissertation on the foundations of quantum theory tells the story of a conceptual protagonist I have called “Epistemic Constraint.” Here, epistemic constraints are the definite, intersubjectively agreeable, ordinary-language conditions under which experiments are described.

The usual formulation of the quantum measurement problem, which I call the Schrodingerian measurement problem, has the structure of an anomaly: if we take quantum theory at face value, we expect no definite values, and yet we see definite values in experiments. The responses to this problem have been either to solve it or to dissolve it. These responses, which have taken the form …

Intergroup Relationship Attitudes Among Multicultural Adolescents In South Korea: Friendship, Dating, And Marriage, Jeewoo Shin

Electronic Theses & Dissertations (2024 - present)

This dissertation asks how multicultural adolescents in South Korea develop their attitudes toward crossing group boundaries in social and intimate life—whom they would accept as a close friend, a romantic partner, and a spouse—and what factors shape these attitudes. Korea’s immigrant population has grown more than seventyfold since 1990, largely through marriage migration, and the children of those unions are now reaching adulthood. Research on these adolescents has focused on how well they adjust, leaving open how they themselves come to view relationships across group lines.

Using eight annual waves of the Multicultural Adolescent Panel Study (N = 1,112), which …

Drivers Of Extreme Streamflow During A Snowmelt-Enhanced Heavy Rainfall And Atmospheric River Event In The Catskill Mountains Of New York, Christopher A. Gilberti

Electronic Theses & Dissertations (2024 - present)

This study uses atmospheric reanalysis, precipitation and snow water equivalent (SWE) analyses, mesonet observations, and streamflow records to examine the impact of an atmospheric river storm that produced heavy rainfall and snowpack ablation across the Catskill Mountains of New York on 24–25 December 2020. Earlier in December, an antecedent storm produced SWE values in the Catskills above the 90^th percentile for that point in the season. The atmospheric river event followed with strong southerly warm-air advection ahead of an anomalously deep trough, temperatures and dewpoints that exceeded 10°C, and heavy orographically enhanced rainfall and rapid snowmelt. Sensible heat fluxes …

Where Perspectives Meet: A Comparative Case Study Of How Participatory Practices Shape Deliberation During District-Level Educational Change, Gregory Vincent Massara

Electronic Theses & Dissertations (2024 - present)

Public education in the United States is socially and politically constructed, and ongoing reforms increasingly require collaborative engagement among diverse stakeholders amid heightened divisiveness. This mixed methods comparative case study examined how educational stakeholders make sense of one another’s perspectives during district-level collaborative work and the conditions that may foster conscientization, the critical reflection on one’s positionality. Two school districts developing a Profile of a Graduate (POG) and one engaged in deliberation about the relationship between public and charter schools within its community serve as comparative cases. The study triangulated meeting observations, a post-deliberation survey of stakeholders (N = 43), …

Victimized And Criminalized: The Intertwined Narratives Of Trauma And Offending, Caitlin Maria Udas

Electronic Theses & Dissertations (2024 - present)

How do pathways between childhood victimization, drug use, and offending behavior vary for recordholders of different races and genders? Prior literature and theory indicates that there are distinct processes that can link childhood victimization to drug use and other offending behavior. These processes are rooted at least partially in experiences of racism/discrimination, placement relative to sociocultural power structures, and norms established over one’s childhood through peer and familial influences. However, less is known about how these differ by race, gender, and the intersection thereof. This dissertation examines the intersectional differences in narrative pathways that link childhood victimization, drug use, and …

Analysis Of Vertical Tropospheric Atmospheric Profiles Associated With Extreme Rainfall Events Over KauaʻI, HawaiʻI, Amanda Maria Maminimini

Electronic Theses & Dissertations (2024 - present)

Extreme rainfall is a persistent hazard in the Hawaiian Islands, where steep terrain and short catchments convert heavy rain into damaging floods with little warning. The trade wind inversion, a subsidence-driven stable layer that caps the marine boundary layer over the subtropical North Pacific, limits the depth of convection and is therefore expected to govern whether available moisture can be converted into extreme rainfall. Previous work has characterized the inversion climatologically and has related the El Niño-Southern Oscillation (ENSO) and the Pacific-North American (PNA) pattern to Hawaiian rainfall totals, but the behavior of the inversion on the specific days when …

A Comprehensive Investigation Of Service Utilization In Innovative Models Of Hepatitis C Care And Treatment For Persons Who Inject Drugs In New York State, Amanda C. Sue

Electronic Theses & Dissertations (2024 - present)

Hepatitis C virus (HCV) is the most prevalent blood-borne infection in the United States and is primarily transmitted through the sharing of unsterilized drug injection equipment. With surges in opioid overdose deaths, there has been an increase in people diagnosed with HCV that can be attributed to persons who inject drugs (PWID) in the United States. PWID have therefore been identified as a priority population to achieve the goal of eliminating HCV as a public health threat. Despite the availability of safe and effective direct-acting antiviral (DAA) therapies that can cure people with HCV, uptake of HCV treatment in PWID …

The Predictability And Verification Of Precipitation From Landfalling Tropical Cyclones Using An Object-Based Framework, Melissa Piper

Electronic Theses & Dissertations (2024 - present)

Precipitation from landfalling tropical cyclones (TCs) poses a significant risk to life and property in both coastal and inland communities. Early warning systems can help mitigate the impacts of TC-induced flooding; however, this requires accurate quantitative precipitation forecasts (QPFs). Forecasting precipitation from landfalling TCs is a challenge, as the intensity, duration, and location of precipitation can be dependent on numerous storm-related and environmental factors. Previous studies have attempted to identify and correct NWP model deficiencies and reduce forecast uncertainty by applying traditional and advanced verification metrics to TC QPF. However, these studies have mostly used gridpoint verification metrics, limited samples …

Gender Inequality In Afghanistan's Public Schools: Provincial Disparities Amid Historical And Political Change, 2002-2021, Enayatullah Nasir

Electronic Theses & Dissertations (2024 - present)

This dissertation examines the persistence and spatial concentration of gender-based educational inequality in Afghanistan's public school system from 2002 to 2021–– a period spanning post-2001 reconstruction, the expansion of the Republic era, and the reversal under the second Taliban regime. Despite substantial international investment and two decades of repeated commitments to gender parity, access to and progression through public schooling remained profoundly uneven across the country’s thirty-four provinces. The Gender Parity Index values differ sharply between provinces, and those with the lowest overall enrollment tend to exhibit the widest gender gaps. Existing scholarship has concentrated on the national level, obscuring …

High-Tcr Multivalence Vanadium Oxide Thin-Films From Deposition Parameter Control To Microbolometer Applications, Latika Susheel M. Chaudhary

Electronic Theses & Dissertations (2024 - present)

This thesis details the development of multivalence-nanostructured vanadium oxide (VOₓ) thin films for uncooled microbolometer applications, with a systematic optimization of magnetron-sputtering parameters. The temperature coefficient of resistance (TCR), resistivity, and optical response of VOₓ thin-film sensing layers are controlled by valence composition, grain growth, and surface morphology. The primary goal was to achieve a high TCR with low resistivity to improve thermal detector performance.

Multivalent VOₓ thin films were deposited on silicon, SiO₂, and glass substrates using DC magnetron sputtering. Three key parameters were systematically varied: Ar:O₂ ratio (18:2 to 15:5), deposition time (60–120 minutes), and DC power (300W …

Weather-Related Road Condition Detection Using Co-Developed Machine Learning Methods, Carly Sutter

Electronic Theses & Dissertations (2024 - present)

Transportation agencies make critical operational decisions during hazardous weather events, including assessment of road conditions and resource allocation. In this study, machine learning models are developed to provide additional support for the New York State Department of Transportation (NYSDOT) by automatically classifying road conditions across the state. Convolutional neural networks and random forests are trained on NYSDOT roadside camera images and weather data to predict road surface conditions. This task draws critically on a labeled dataset of 22,000 camera images containing six road surface conditions (severe snow, snow, wet, dry, poor visibility, and obstructed) generated from an iterative hand-labeling process …

On The City-Scale Energy Balance Under Electrification And Renewable Generation: The New York City Case, Nour Elgalad

Electronic Theses & Dissertations (2024 - present)

Integration of renewable resources to meet the growing energy demand of dense urban regions is becoming a global priority under decarbonization mandates. This study contributes to these ongoing efforts by assessing the feasibility of using locally deployable urban renewable resources, namely offshore wind in the New York Bight region and rooftop photovoltaic (PV) systems over New York City, to meet the electricity demand of the city, and the grid vulnerabilities that emerge, during two contrasting extreme-weather periods: the intense heatwave of June 2025 and a fully electrified winter cold snap in January 2018. A unified, meteorologically driven modelling framework, based …

Through Our Eyes: An Exploration Of Hope Among Opportunity Youth, Judith L. Fenlon

Electronic Theses & Dissertations (2024 - present)

Opportunity youth—young people aged 16–24 who are disconnected from both school and employment—experience significant barriers to successful transitions into adulthood. Existing research has largely focused on deficits, risk factors, and outcomes associated with disconnection, often overlooking the strengths, resilience, and aspirations of these young people. Hope has been identified as a critical factor associated with educational achievement, psychological well-being and future orientation; however, little research has explored how opportunity youth experience hope in the context of systemic inequities. The purpose of this study was to explore the lived experience of hope among low-income opportunity youth and to examine the factors …

Masses And The Gothic In The English Novel: 1700-1820, Szu Ying Chen

Electronic Theses & Dissertations (2024 - present)

This dissertation studies the eighteenth-century English novel and expands the understanding of realism by rereading realist novels through Gothic representations of the masses. The conventional understanding of realism is shaped by Ian Watt’s canonical concept of “formal realism” in The Rise of the Novel and Jürgen Habermas’s conception of the bourgeois public sphere. It identifies realism with a vision of civility grounded in the modern individual and bourgeois social reality. However, the masses and the Gothic challenge this conception of the novel’s realism by representing the social as constituted by collective agency, political violence, and struggles over power rather than …

Improving Modeling Of Corrosion Products In The Primary Circuit Of Light Water Reactors Through The Experimental Determination Of Crud Characteristics, Sri Saravana Konganapuram Narasimma Bharathi

Electronic Theses & Dissertations (2024 - present)

High-temperature water flowing through the coolant circuits in pressurized water reactors (PWRs) creates a harsh environment, deteriorating these materials. This corrosion results in the formation of oxide layer(s) primarily composed of nickel ferrites, iron oxides, nickel oxides, and other nickel-iron-chrome spinel oxides. Being exposed to fluid with high flow rates and pressure, these oxide layers can be eroded, resulting in particulate fouling due to the release of corrosion products (Chalk River Unidentified Deposits, CRUD) into the coolant circuit. When CRUD subsequently deposits on fuel surfaces, it negatively affects the fuel performance (heat transfer and fuel failure); in addition, the particles …