Digital Commons Network^™

Type Iv Secretion Systems: Reconciling Diversity Through A Unified Nomenclature, Peter J Christie, Gabriel Waksman, Ronnie Per-Arne Berntsson, Nicolas Soler, Nathalie Leblond-Bourget, Badreddine Douzi

Faculty, Staff and Student Publications

Type IV secretion systems (T4SS) are versatile nanomachines responsible for the transfer of DNA and proteins across cell envelopes. From their ancestral role in conjugation, these systems have diversified into a superfamily with functions ranging from horizontal gene transfer to the delivery of toxins to eukaryotic and prokaryotic hosts. Recent structural and functional studies have uncovered unexpected architectural variations not only among Gram-negative systems but also between Gram-negative and Gram-positive systems. Despite this diversity, a conserved set of core proteins is maintained across the superfamily. To facilitate cross-system comparisons, we propose in this review a unified nomenclature for conserved T4SS …

Precision Acoustofluidics For High-Throughput Mechanobiology In Suspension Cells, Kaichun Yang, Ruoyu Zhong, Ke Li, John Mai, Pengzhan Liu, Ye He, Joseph Rich, Ying Chen, Janna Wang, Zhiteng Ma, Zhiteng Ma, Xianchen Xu, Qian Wu, Tony Jun Huang

Faculty Publications

Mechanomodulation, the process of altering cellular behavior through applied mechanical forces, plays a critical role in physiological processes and has substantial implications for cancer therapy, immunology, and drug development. However, precise and efficient stimulation of nonadherent cells remains a major challenge, limiting the investigation of mechanotransduction pathways and the development of targeted therapeutics. Here, we developed an acoustofluidic platform named Suspension-cell Targeted Response to Excitation via Acoustofluidic Mechanomodulation (STREAM) to enable precise, high-throughput stimulation of suspension cells. STREAM accomplishes this using 101.14-megahertz high-frequency surface acoustic waves to deliver controlled mechanical stimulation at a throughput of 500,000 cells per minute. STREAM …

Laboratory Evaluation Of Armie, A Portable Sps30-Based Low-Cost Sensor Node For Pm 2.5 Monitoring., Asbjørn Kloppenborg, Louise B Frederickson, Rasmus Ø Nielsen, Clive E Sabel, Tue Skallgaard, Jakob Löndahl, Jose G C Laurent, Torben Sigsgaard

School of Geography, Earth and Environmental Sciences

BACKGROUND: Low-cost particulate matter sensors have enabled new opportunities for exposure monitoring but require evaluation before application in epidemiological studies. This study assessed the performance of the SPS30 sensor integrated into the ARMIE portable monitoring sensor-node under controlled laboratory conditions.

METHODS: Sensors were co-located with two comparison instruments-the optical DustTrak photometer and the combined Scanning Mobility Particle Sizer (SMPS) and Aerodynamic Particle Sizer (APS)-across multiple aerosol sources, including candle burning, cooking, cigarette smoke, and clean air, under both regular and high-humidity conditions. Calibration performance was evaluated using leave-one-sensor-out and leave-one-source-out approaches.

RESULTS: The ARMIE node demonstrated strong agreement with the …

Person-Centered Care In Adult Auditory Rehabilitation: A Scoping Review, Marien Alet Graham, Nannette Nicholson, Rachel Glade, Sonja Delport, Faheema Mahomed-Asmail

Communication Disorders and Occupational Therapy Faculty Publications and Presentations

Objective To scrutinise the efficacy of person-centered care (PCC) in enhancing outcomes for adults navigating hearing loss through a comprehensive examination of literature on PCC in auditory rehabilitation (AR). Design A scoping review was conducted following Joanna Briggs Institute guidelines and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses for Scoping Reviews (PRISMA-ScR) reporting standards. A context framework guided the research question. Study Sample Structured searches across multiple databases identified 36 records which were categorised by research design, mapped by the first author's country, and depicted by number of publications per year. Six identified elements of PCC were anaylzed …

Melatonin Use In Young Children: A Systematic Review, Chelsea L. Kracht, Grace Bolamperti, Rob Breeden, Madeline Crocker, Danielle N. Christifano, Robert C. Gibler, Grace Gyllenborg, Peter Johnson, Jacob Lovell, Lauren Mathews, Obianuju Onuoha, Natesh Samaroo, Anna S. Trofimoff, Perry Weidling, Anna Wallisch

Student Publications

Importance: Melatonin is the leading cause of unsupervised medication exposure and overdose in emergency departments for young children (aged 0-6 years). Existing literature has documented the benefits of melatonin in older children (aged 7-18 years) with neurologic conditions but has yet to examine young children.

Objective: To examine the long-term outcomes (safety and effectiveness) associated with melatonin use in young children.

Evidence review: Nine databases, including Ovid MEDLINE, Embase, and Web of Science; 2 clinical trial registries; existing subject matter systematic reviews; and forward and backward citation of included articles were reviewed from inception to February 26, 2025, to identify …

Career Plans Among Graduating Us Emergency Medicine Residents, Dave W. Lu, Bo Gu, D. Mark Courtney, Bryan G. Kane, Michelle D. Lall, Michael Gottlieb, Yvette Calderon, Christopher Bennett

Department of Emergency Medicine Faculty Papers

IMPORTANCE: The emergency medicine (EM) workforce is undergoing complex change, including a potential projected physician surplus, the volatile and evolving interests of medical students, and the continued high rates of burnout. Understanding the career intentions of graduating residents is critical to inform workforce planning.

OBJECTIVE: To examine the career plans, anticipated career durations, and key factors associated with the career decisions of graduating US EM residents.

DESIGN, SETTING, AND PARTICIPANTS: This cross-sectional survey study, which sampled graduating residents from all Accreditation Council for Graduate Medical Education-accredited categorical EM programs, was conducted after the 2023 American Board of Emergency Medicine In-Training …

Reported Safety Practices Of Publicly Advertised Psychedelic Retreats, Amy L Mcguire, Logan Neitzke-Spruill, Jill O Robinson, Caroline S Beit, Nikita Singh, David S Mathai, Lynnette A Averill

Center for Medical Ethics and Health Policy Staff Publications

Importance: The availability of psychedelic retreats has grown to meet the demand for access to these substances. Despite centuries of use among Indigenous communities, psychedelics can pose serious risks for some users.

Objective: To determine safety precautions that retreat organizations that offer psychedelic substances currently use.

Design, setting, and participants: This qualitative study included structured interviews conducted by phone or email with representatives from 49 organizations publicly advertising psychedelic retreat offerings from July to October 2023. Organizations were eligible if they marketed their services in English, offered at least 1 psychedelic substance, and made contact information available online. Organizations were …

Toward A British Guitar Canon: Ernest Shand’S Collected Works, Declan Hickey

Soundboard Scholar

A review of Guitar Music from Late Victorian England: Collected Works, by Ernest Shand, edited by Stanley Yates (Classical Guitar Study Editions, 2022), publisher's website.

Pengujian High Fidelity Prototipe Media Pembelajaran Interaktif Bahasa Inggris Dengan Gamifikasi Menggunakan User Experience Questionare, Adhitya Prastyadi, Meizano Muhammad Ardhi, Daniel Rinaldi, Margaretha Karolina Sagala

Jurnal Sosial Humaniora Terapan

Abstract

Testing a Hi-Fi Prototype of Interactive English Learning Media with Gamification Using UEQ

This study aims to test and evaluate the User Experience (UX) quality of a High-Fidelity prototype for interactive English learning media integrating gamification elements. The research is motivated by the low English proficiency and motivation among Indonesian students, and the potential of digital media and gamification to enhance learning engagement. Inspired by the success of the Duolingo application, this prototype was designed to create an enjoyable and effective learning experience. A quantitative research methodology was employed, involving high school students as participants selected via purposive sampling. …

Integrated Optimization Of Underground Mine Ventilation Using Hardy Cross, Monte Carlo Simulations, And Machine Learning Techniques: A Step Toward Sustainable Mining, Hussein A. Saleem

Journal of Sustainable Mining

Underground mine ventilation is crucial for ensuring worker safety, air quality, and operational efficiency. Effective optimization of ventilation systems reduces energy consumption, enhances airflow distribution, and minimizes risks associated with harmful gases and fire hazards. This study proposed an integrated framework combining the Hardy Cross (HC) method, Monte Carlo (MC) simulations, and machine learning (ML) techniques to optimize the ventilation system at the Jabal Sayid mine in Saudi Arabia. The HC method was employed to provide deterministic baseline airflow calculations, while the MC simulations accounted for uncertainties in resistance values and environmental conditions, generating probabilistic distributions of key parameters. Among …

Prevalence Of Sexual Harassment Among Nurses And Nursing Students In A Culturally Conservative Country, Hanadi Mohamad Nur Steitiyeh, Fatin Ahmad Safa, Jana Daoud Al Hajj Daoud, Adam Tarek Ikkawi, Sahed Ali Fawaz, Hiba Deek

BAU Journal - Science and Technology

The prevalence of sexual harassment among nurses and nursing students in Lebanon is an unidentified social concern. This study aims to identify this prevalence and assess the related factors. Using a self-administered questionnaire the sociodemographic characteristics, workplace variables, physical appearance, and the Sexual Experience Questionnaire (SEQ) were assessed, the data was analyzed using Statistical Package for the Social Sciences (SPSS) version 25. A total of 380 participated with 71.8% being female and 63.9% aged between 18 and 25. Sexual harassment was experienced by 91 participants (23.9%) and occurred mainly in the patients’ rooms and during procedures. Policies were absent or …

Teacher-Implemented Scaffolding, Sara Dominguez, Vanessa Svihla

Organization, Information and Learning Sciences ETDs

Teacher-implementing scaffolding is fundamental in teaching that was disrupted by the sudden move to emergency remote teaching during the pandemic.  A review of research found trends based on grade and subject and that teacher’s responsiveness was the main contingent processes reported.  Based on this a survey was developed and an exploratory factor analysis was completed.  An analysis of the survey results found differences in teacher agency, self-efficacy, and the supports used when comparing in-person and online teacher-implemented scaffolding.  Qualitative results further support findings and describe teachers’ perspective on the change to the environment, adaptations made, and hinderances noted while supporting …

Making Sense: Envy In Libanius' Declamation 30, Andrew Scholtz

Middle Eastern and Ancient Mediterranean Studies (MEAMS) Faculty Scholarship

Declamation, a genre famous for its sometimes extravagant fictions, has lately been approached as a vehicle for declaimers to reflect on realities familiar to them and their audiences. Reading Libanius' rarely discussed Declamation 30 in just such a self-reflective key, I argue that it explores the mindset of the phthoneros, the "envious man," as a way to make sense of risks posed by unscrupulous rivals. To shed light on this sense-making, I analyze High- and Late-Imperial emotion scripts foregrounding envy’s power to catalyze the formation of dysfunctional networks within and around competitive situations.

The Relationship Between Celebrity Worship And Psychotherapy Preferences, Sean Frydman M.S.

Selected Full Text Dissertations, 2011-

Celebrity worship (CW) is defined as an increased admiration toward a celebrity figure which may lead to excessive interest in their lives (McCutcheon et al., 2021). Intense CW has been found to be associated with a variety of pathological traits, suggesting that individuals with higher CW might benefit from psychotherapy (Sansone & Sansone, 2014). However, no research is available regarding psychotherapy preferences for this population. Research to date has found positive correlations between accommodating patients’ treatment preferences and greater treatment satisfaction and outcomes, stronger alliance, and reduced attrition (Iacoviello et al., 2007; Lindhiem et al., 2014; Swift et al., 2011, …

Pacs Viewbook 2026-2027, Program In Audiology And Communication Sciences

PACS News

No abstract provided.

The Efficacy Of Cgrp Antagonists Versus Other Non-Migraine Specific Medications As Prophylactic Treatment For Episodic And Chronic Migraine, Lauryn C. Hutto

The PA Department Journal of Medical Science

Introduction: Migraines are a disabling neurological condition affecting 12-15% of the population. Migraines are characterized by a unilateral throbbing headache lasting between 4 and 72 hours, often accompanied by photophobia, phonophobia, nausea, or vomiting. Until the approval of the first CGRP antagonist, Erenumab, in May 2018, the prophylactic treatment for migraines relied on non-migraine-specific medications, such as antihypertensives and antiepileptics. Studies have been done to determine the efficacy and safety of the new medications, but few have directly compared them to older non-migraine-specific medications used for prevention. The purpose of this paper is to compare the efficacy of CGRP …

The Role Of Conjunctive Hyperbaric Oxygen Therapy In Decreasing Amputations In Those With Diabetic Foot Ulcers: A Clinical Review, Jazmyne D. Smith

The PA Department Journal of Medical Science

Diabetic Foot Ulcers (DFU) are a common complication of Diabetes Mellitus, which is the most common cause of amputations in the US. The purpose of this clinical review is to analyze the impact of Hyperbaric Oxygen Therapy on reducing amputations and improving healing rates in DFUs. PubMed was searched using the key terms “Diabetic Foot Ulcer,” “Amputation,” and “Hyperbaric Oxygen Therapy.” With the addition of filters, Mesh terms, and Boolean operations, 18 results were yielded. The inclusion and exclusion criteria narrowed the search to 6 articles, which were used for this review. The 6 articles included in this study were …

Pharmacologic Therapy Versus Catheter Ablation For Atrial Fibrillation, Jahkarius Hargrove

The PA Department Journal of Medical Science

Introduction- Atrial fibrillation is a common type of cardiac arrythmia that affects many people across the world. Patients with atrial fibrillation are at high risk for complications and poor outcomes. Stroke is the most prominent complication of atrial fibrillation if left untreated. The purpose of this clinical review is to analyze which modality is a better first line treatment, antiarrhythmic drug therapy or catheter ablation for long term management of this arrythmia.

Methods- Pubmed was searched with a specific search strategy using key terms “cardiac”, “Arrythmia”, “Antiarrhythmic agents”, “radiofrequency ablation”, and “surgical operation”. Operators and filters such as …

Comparing Autografts And Bioengineered Skin Equivalents In The Management Of Severe Burns, Madison Hill

The PA Department Journal of Medical Science

INTRODUCTION: Severe burns are associated with high morbidity, mortality, and treatment costs, often requiring surgical intervention to restore the skin barrier and prevent complications like infection and hypothermia. Autologous skin grafting is the current gold standard for burn wound closure but may not be feasible in cases of large TBSA injuries with limited donor sites. Bioengineered skin equivalents, including acellular dermal substitutes and cell-based therapies, offer potential benefits in wound healing and scar quality while reducing donor site morbidity. This review evaluates the effectiveness of autografts compared to bioengineered skin equivalents in severe burn management, with a focus on healing …

Extracorporeal Shockwave Therapy For Plantar Fasciitis Pain Reduction, Nathan J. Lopez

The PA Department Journal of Medical Science

Introduction: Plantar fasciitis (PF), aka plantar heel pain (PHP), is a degenerative and debilitating musculoskeletal condition that is prevalent across various populations. There is some debate concerning the hierarchy of second-line treatment options. The purpose of this article is to compare the efficacy, as it relates to pain reduction, of extracorporeal shockwave therapy (ESWT) and other invasive, non-surgical interventions (injections, dry needling, etc.).

Methods: PubMed was searched using a specific search strategy with key terms "extracorporeal shockwave therapy" and "plantar fasciitis". Operators and filters were then applied to narrow results to 4 relevant and quality articles for review. …

Prevention Of The Recurrence Of Skin Cancer With The Use Of Nicotinamide, Ryan A. Reibling

The PA Department Journal of Medical Science

Introduction: Skin cancer is the most common form of cancer worldwide, caused by the accumulation of UV ray exposure that people are exposed to daily. The treatment options for skin cancer are costly and inconvenient, with a high chance of recurrence in different sun-exposed areas. Nicotinamide, a form of vitamin B3, has shown promising outcomes in reducing the chance of recurrent in high-risk individuals. The purpose of this review is to examine recent literature on the effectiveness of nicotinamide supplementation in lowering the risk of skin cancer recurrence compared to individuals who do not take it.

Methods: A comprehensive PubMed …

Post-Surgical Prognostic Outlook Comparison Of Off-Pump Vs. On-Pump Cabg Procedures, Tanner A. Hendricks

The PA Department Journal of Medical Science

Introduction: Coronary artery disease in the United States had 680,981 deaths in 2023 alone with 400,000 CABG procedures being done. Coronary artery bypass grafting is a procedure in which coronary arteries occluded by fatty plaques are revascularized to restore blood flow to the myocardium. There are two effective options for this procedure, one being the on-pump approach, and the other being off-pump. Both methods carry risks, such as stoke and MI, as well as benefits, but the question of which carries the better outlook on mortality and complications is up for debate. The purpose of this paper is to study …

Efficacy Of Metformin Compared To Insulin In The Management Of Gestational Diabetes, Sarah Mchale

The PA Department Journal of Medical Science

Intro: Gestational diabetes (GDM) is a condition in which pregnant women are unable to use insulin effectively, leading to increased levels of glucose in the body. Although insulin has traditionally been a first-line pharmacologic treatment for GDM, metformin is increasingly being explored as an alternative. The purpose of this clinical review is to analyze whether metformin could be a safe and effective oral antihyperglycemic option compared to insulin in the treatment of GDM.

Methods: PubMed was searched with a specific search strategy using the key terms “insulin,” “metformin,” “gestational diabetes,” and “blood glucose.” Operator and filters narrowed results to 19 …

Efficacy Of Zuranolone Use For Postpartum Depression, Diana G. Welliver

The PA Department Journal of Medical Science

Introduction: Postpartum depression is a major form of depression that occurs anytime within the first year after a woman gives birth. It is characterized by low moods, increased feelings of sadness and anxiety, and a decreased interest in one’s baby. It is commonly treated with the use of selective serotonin reuptake inhibitors (SSRIs), which present with negative side effects and have a long duration of onset. The purpose of this study is to evaluate the efficacy of zuranolone, a fast-acting neuroactive steroid and GABA-A receptor modulator, on its ability to reduce symptoms of postpartum depression.

Methods: The PubMed database was …

Deep Brain Stimulation For The Management Of Non-Motor Symptoms Related To Parkinson’S Disease, Kyla A. Wallaszek

The PA Department Journal of Medical Science

Introduction: Deep brain stimulation (DBS) is a modern neurosurgical technique where electrodes are implanted in specific brain areas and deliver electrical impulses in order to help regulate abnormal brain activity. DBS is used for the management of several neurological conditions and was approved by the FDA for the treatment of Parkinson’s disease in 2003. The purpose of this review is to analyze the effectiveness of DBS for the management of the non-motor symptoms related to Parkinson's disease.

Methods: PubMed was searched using the key terms “Parkinson disease,” “deep brain stimulation,” “voice,” “sleep,” “mood,” “cognition,” and “dysphagia.” Operators and filters narrowed …

Labor Induction Versus Expectant Management In Postterm Pregnancy: A Clinical Review, Marisa Putrasahan

The PA Department Journal of Medical Science

Introduction: Postterm pregnancy is associated with increased morbidity and mortality of infant and mother. Current practice varies in the management of late- and postterm pregnancies, with much discussion surrounding the risks and benefits of the intervention options provided to pregnant patients. This study aims to review literature comparing the effectiveness of induction of labor (IOL) with elective management (EM) in reducing adverse perinatal and maternal outcomes for pregnant patients approaching postterm.

Methods: A literature search was performed on PubMed using key terms “late term pregnancy,” “induction of labor,” and “expectant management.” Operators and additional search filters narrowed results …

Outcomes Of Surgical Versus Transcatheter Aortic Valve Replacement: A Clinical Review, Grace Stang

The PA Department Journal of Medical Science

Introduction: Surgical aortic valve replacement (SAVR) has been the predominant

treatment for aortic stenosis (AS) for decades. However, transcatheter aortic valve replacement (TAVR) is becoming increasingly popular. Originally, TAVRs were only performed on patients who were deemed high-risk for surgery and would have died without the valve replacement. The purpose of this paper is to determine if TAVR or SAVR has better health outcomes for all patients no matter their surgical risk.

Methods: A search via PubMed database was done using the key words “aortic stenosis”, “surgical aortic valve replacement”, “transcatheter aortic valve replacement”, and “mortality.” Additional search filters were …

Efficacy And Safety Of Semaglutide In Adults Without Diabetes Who Are Overweight Or Obese, Rebecca Petty

The PA Department Journal of Medical Science

INTRODUCTION:

Obesity is associated with an increased risk of cardiovascular and metabolic disorders and contributes to the leading cause of death in the US — heart disease. Glucagon-like peptide-1 (GLP-1) receptor agonists (RAs) have recently emerged as a treatment option for obesity. The purpose of this clinical review is to evaluate the efficacy and safety of semaglutide in adults without diabetes who are overweight or obese.

METHODS:

PubMed was searched using a precise search strategy and the key terms “semaglutide,” “weight loss,” and “without diabetes.” Results were filtered and narrowed using specific inclusion and exclusion criteria. Four high-quality studies were …

“Ecmo Anticoagulation: Should We Consider Bivalirudin Over Heparin?”, Confidence Paul

The PA Department Journal of Medical Science

Introduction: Extracorporeal membrane oxygenation (ECMO) requires systemic anticoagulation to prevent thrombotic events within the circuit. The use of unfractionated heparin has been the traditional anticoagulant of choice. Bivalirudin, a direct thrombin inhibitor, offers an alternative that has theoretical and observed benefits. The purpose of this clinical review is to evaluate whether bivalirudin provides superior safety and efficacy compared to UFH in ECMO patients.

Methods: PubMed was searched with a specific search strategy using key terms “Extracorporeal membrane oxygenation” AND “indirect anticoagulants” AND “deep vein thrombosis”. Operators and filters narrowed the results to four relevant, quality articles for review.

Results: In …

Effects Of Angiotensin-Converting Enzyme Inhibitors And Angiotensin Receptor Blockers On Covid-19 Outcomes In Severely Ill Patients, Madison L. Edwards

The PA Department Journal of Medical Science

Introduction: Coronavirus disease 2019 (COVID-19) is a contagious disease caused by the virus SARS-CoV-2 and can cause debilitating illness in vulnerable patient populations. The purpose of this clinical review is to analyze the effects of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers on the clinical course and severity in COVID-19 adult patients.

Methods: PubMed was searched with a specific search strategy using key terms “adult,” “COVID-19,” and “RAAS inhibiting medications.” Specific operators and filters narrowed the results to a total of five relevant, quality articles for review.

Results: Two articles were randomized controlled trials that directly compared the continuation of …