Digital Commons Network^™

Image Circulations And Economic Imagination: Framing The Peruvian And Chilean Peripheries At The End Of The 19th Century, Alexandre Puche

Artl@s Bulletin

Abstract: This study explores two cases of photographic circulation between Peru, Chile and France in the late nineteenth century to show how images contributed to the requalification of the region within global commercial geography. It also proposes a historical methodology that considers visual repetition as a traceable product of transnational circulation. This approach sheds light on both certain mechanisms behind Atlantic propaganda regarding South America’s economic potential and the structuring role such circulations played in shaping regional representations.

Résumé: Cette étude examine deux cas de circulations photographiques entre le Pérou, le Chili et la France à la fin du XIXe …

Antimicrobial Resistance Of Cultivable Bacteria Isolated From Sorcerer’S Cave In Texas, Jennifer R. Huddleston, David E. Sanderson, Braden J. Smith, Joshua M. Brokaw, Evan M. Babb, Jeffrey T. Wooliscroft

International Journal of Speleology

Studying caves with minimal human contact offers insights into antimicrobial resistance before human influence. In this study, we isolated 315 bacterial strains from Sorcerer’s Cave in Texas and evaluated their resistance to seven common antimicrobials. Under half (41.4%) of the Gram-positive isolates and 68.4% of the Gram-negative isolates were resistant to three or more antimicrobials. The two most common genera identified were Pseudomonas and Bacillus. Compared to bacteria isolated in previous cave studies, Sorcerer’s Cave bacteria exhibited more extensive antimicrobial resistance. This study underscores the importance of minimally disturbed cave environments in advancing our knowledge of antimicrobial resistance present …

“A Questionable Culture That Has Dominated Rté For Too Long”: Early Funding Structures And The Nature Of Irish Public Service Media, Roddy Flynn

Irish Communication Review

RTÉ is unusually reliant on advertising revenue in comparison with other European public service media. This article suggests that understanding why this is the case requires a look at the longer history of RTE’s finances, back to the era when the broadcasting service was directly run as an element of the Department of Posts and Telegraphs and thus, indirectly, the Irish state. This status notwithstanding, a sequence of government decisions in the 1930s created a situation whereby the public service medium became reliant on advertising income for its survival, a dependency relationship which not only persisted but became even more …

Discovering New Music: Curators In Irish Radio, Ciarán Ryan

Irish Communication Review

From the arrival of pirate radio stations to the establishment of RTÉ 2FM and the later introduction of commercial radio, Irish audiences have had access to various forms of popular music radio for over half a century. Non-chart or ‘alternative’ music programming is a part of the Irish radio landscape that has been under-researched until now. Primarily scheduled late at night, these programmes have had hosts who have fostered intimate connections with smaller, niche audiences through their musical knowledge and personally selected track listings. Looking at industry perspectives from various strands of broadcasting in Ireland, this research examines the value …

Crystal Sets And Listening-In: Radio In Ireland Before 2rn, Stephanie Rains

Irish Communication Review

When 2RN began broadcasting from its studios on Henry Street in Dublin on 1 January 1926, it became the first radio station in the Free State. However, it was very far from being the start of radio on the island of Ireland, as there was already a community of amateur operators and engineers conducting technical experiments. This article explores the radio landscape in Ireland which 2RN joined and transformed. The early enthusiasts often not very concerned with programming or with most of radio’s possibilities as a form of entertainment, but did have a very international perspective on the medium’s possibilities. …

Icr Radio Centenary Issue: Table Of Contents And Bios, Rosemary Day

Irish Communication Review

No abstract provided.

The Centenary Of Radio In Ireland 2026: Introduction To Special Issue Of Irish Communications Review, Rosemary Day

Irish Communication Review

This article introduces the special issue of Irish Communications Review, 2026, that celebrates the centenary of radio in Ireland. It discusses the aims and aspirations announced on the first night of broadcasting, 1st January 1926 and gives details of the vision shared by Douglas Hyde on that night. It briefly describes the content of each of the seven articles in the special issue. Each one is based on new research and each one investigates a different aspect of the development of Irish radio over the past one hundred years and considers the implications and impact of those developments.

Cancer Literacy And Social Determinants Of Health: An Epidemiological Analysis Of Trust, Digital Engagement, And Healthcare Utilization In Cancer Information Seeking, Kimberly Leeann Hazel

Walden Dissertations and Doctoral Studies

The rise of online health information has increased access to cancer resources but also amplified misinformation, creating trust gaps that threaten prevention, treatment, and health equity. This study examined how trust in cancer information sources, online information-seeking, and healthcare perceptions relate among U.S. adults. Guided by the health information seeking behavior, the socioecological model, and the structural influence model of health communication, data from the 2022 Health Information National Trends Survey (N = 6,197) were analyzed with logistic regression, mediation, and moderation modeling, controlling for demographics. Trust in government agencies predicted greater cancer information seeking (odds ratio [OR] = 1.94, …

National Survey Of Physical Therapists’ Participation As Health Educators In Physical Activity Promotion Among Older Adults, Casey Nicole Mokres

Walden Dissertations and Doctoral Studies

Physical inactivity among older adults remains a major national and global public health concern linked to preventable morbidity, mortality, and rising healthcare costs. Physical therapists are uniquely positioned to promote physical activity (PA) through health education, yet their engagement in this role is not well defined. This quantitative cross-sectional study examined associations between clinical practice factors—years of experience, board certification status, and practice setting—and three domains of the theoretical domains framework (knowledge, skills, and behavioral regulation) related to PA promotion among older adults. The framework guided identification of behavioral and contextual factors influencing therapists’ delivery of PA promotion interventions. Data …

Employment Stability And Security Of Low-Wage Workers In The United States, Mathieu Despard, Guangli Zhang, Stephen Roll

Center for Social Development Research

One quarter of workers in the United States make $35,000 or less, and nearly half of these are between 35 and 64 years old. Forty percent are caring for children in the home. As temporary and gig working arrangements become increasingly common, this brief explores the stability of work and income for low-wage workers. The analyses draw upon data from the Workforce Economic Inclusion and Mobility survey administered to a nationally representative sample of U.S. workers earning less than 250% of the federal poverty line. The findings from this work have direct implications for employment practices and labor policies.

Distribution Of New Statistics Of Parking Functions And Their Generalizations, Stephan Wagner, Catherine H. Yan, Mei Yin

Mathematics: Faculty Scholarship

In this paper we present new results on the enumeration of parking functions and labeled forests. We introduce new statistics on parking functions, which are then extended to labeled forests via bijective correspondences. We determine the joint distribution of two statistics on parking functions and their counterparts on labeled forests. Our results on labeled forests also serve to explain the mysterious equidistribution between two seemingly unrelated statistics in parking functions recently identified by Stanley and Yin and give an explicit bijection between the two statistics. Extensions of our techniques are discussed, including joint distribution on further refinement of these new …

Systematic Review And Meta-Analysis Of Placebo Cure In Onychomycosis Clinical Trials, Julianne M. Falotico, Zachary J.K. Neubauer, Anjile An, Shari R. Lipner

Student Papers, Posters & Projects

No abstract provided.

Esg Performance In The Regulatory Transformation Era: A Systematic Thematic Review (2020–2024), Jiyeon Kim Ph.D., Wooyoung Yang

Faculty Publications

Introduction:

The 2020-2024 period represents a regulatory transformation era in ESG research, marked by mandatory disclosure frameworks (CSRD/ESRS, SEC climate rules, ISSB standards) replacing voluntary approaches. This creates a natural experiment for examining ESG-performance relationships under compulsory reporting. Despite extensive voluntary-period literature, limited research addresses how mandatory frameworks alter these relationships during regulatory transformation.

Methods:

We conducted a systematic thematic review following PRISMA 2020 guidelines (INPLASY202570105). Comprehensive database searches (2020–2024) yielded 4,441 records; after screening (Cohen's κ = 0.89), 17 high-quality studies met inclusion criteria (12 primary search, 5 ESRS-specific supplementary search). Thematic analysis identified ten interconnected themes grounded in …

The Role Of Micrornas As Potential Biomarkers In Diffuse Large B-Cell Lymphoma, Eirini Panteli, Epameinondas Koumpis, Vasileios Georgoulis, Georgios Petros Barakos, Evangelos Kolettas, Panagiotis Kanavaros, Alexandra Papoudou-Bai, Eleftheria Hatzimichael

Computational Medicine Center Faculty Papers

Diffuse large B-cell lymphoma (DLBCL) is the most common and clinically aggressive subtype of non-Hodgkin lymphoma (NHL). While novel therapies such as rituximab and polatuzumab vedotin have led to improved outcomes, approximately 35% of patients eventually develop relapsed or refractory disease. MicroRNAs (miRNAs), a class of endogenous single-stranded RNAs approximately 22 nucleotides in length, play a pivotal role in the regulation of gene expression at the post-transcriptional level through interactions with complementary target RNAs and contribute significantly to the development, progression, and treatment response of DLBCL. Oncogenic miRNAs, such as miR-155, miR-21, and the miR-17-92 cluster, promote proliferation, survival, immune …

Exploring Parenting Experiences: Fathers And Mothers Raising A Child With Autism, Simmi Santha

Walden Dissertations and Doctoral Studies

The experiences of parenting a child with autism spectrum disorder (ASD) have been widely studied in Western contexts. Still, limited research has explored how sociocultural factors shape these experiences in India. This qualitative study aims to address this gap by exploring and comparing the lived experiences of mothers and fathers raising a child with ASD in Kerala, India. The purpose of this study was to investigate how gender roles, cultural expectations, and social structures impact parental adaptation, coping, and caregiving practices. Bronfenbrenner’s ecological systems theory and Crenshaw’s ideas of intersectionality provide the conceptual framework of this study. Using an interpretative …

A Policy Reversal As Structural Break: A Lesson From China’S Land Lease Financing For Infrastructure, Yilin Hou, Lin Li, Lei Shao

Center for Policy Research

Land-based revenues as a fiscal instrument to finance infrastructure tie public investment to real estate markets, where demand fluctuations cause fiscal consequences. This paper takes policy reversals as structural breaks and examines their impacts on infrastructure investment. We dissect China’s 2016 policy reversal that disallowed developers to finance land purchase with debt, causing sharp declines in local government land revenues, slashing their fiscal base for infrastructure investment. Using prefecture-level panel data and continuous difference-in-differences identification, we estimate the reversal reduced land-lease revenues by 55%. Two-stage least squares estimates suggest a 10% land-revenue decline translates into 6.6% investment reduction. Decomposing the …

Ai In Ocean Traffic Monitoring, Tyler Hawkins, Steven D. Meyers, Aishlin Ingraham, Mark E. Luther

Making Waves REU

The Maritime Automatic Identification System (AIS) produces over 100 terabytes of data annually. offering vital insights into globaJ vessel traffic, identity, and navigation patterns. However, the massive volume and inconsislent quality of AIS data introduce challenges for researchers seeking to extract reliable and applicable information. This study investigates the, effectiveness of Julius Al, an off-the-shelf data science platform, for streamlining the analysis of a ilarge AIS dataset, spanning 2015 to 2019 and covering over 42 million messages from Florida's five busiest ports. The results were compared to a previous human analysis. By leveraging only natural language prompts, we explore how …

Collaborating With ‘Blue Food’ System Stakeholders To Achieve Optimal Nutritional Health And Wellbeing In Less Affluent Communities, Clare Pettinger, Louise Hunt, Carol Wagstaff

School of Health Professions

UK food system transformation is urgently needed, but to date, minimal research has investigated ‘blue foods’ probably because they are ethically nuanced. There exists a paradox whereby materially deprived communities should be eating more fish to meet nutritional requirements, yet there is a global ‘red flag’ around global overfishing. New collaborative and creative solutions are, therefore, needed to tackle such food system inequities. By working together, all voices can be equally heard when decisions are being made to improve the system. Similarly, innovation and disruption of established supply chains will enable better access to healthy, affordable and tasty food that …

Characterization Of Inflammatory Pseudotumors In A Large Animal Model Of Liver Cancer, Erik N K Cressman, Samantha Hicks, Natalie W Fowlkes, Danielle L Stolley, Maria Sophia Stenkamp

Faculty, Staff and Student Publications

Background: The development of relevant and robust large animal models of hepatocellular carcinoma is needed to test new therapeutic strategies for this disease. Transgenic approaches hold promise in addressing this complex problem. One such model, the Oncopig, has been reported to develop tumors of up to 4 cm in diameter within 7-14 days at sites of in situ vector inoculation. However, the resulting lesions reportedly contained an extensive inflammatory component that has not been evaluated in detail.

Methods: Herein, we describe our results from multiparametric characterization of the lesions generated using liver biopsy cores incubated in vector solution and replaced …

Loss Of Kdm6a-Mediated Genomic Instability And Metabolic Reprogramming Regulates Response To Therapeutic Perturbations In Bladder Cancer, Pratishtha Singh, Ranit D'Rozario, Bidisha Chakraborty, Swadhin Meher, Deblina Raychaudhuri, Aminah J Tannir, Yang Li, Anurag Majumdar, Jessalyn Hawkins, Yun Xiong, Philip Lorenzi, Padmanee Sharma, Kadir Akdemir, Patrick Pilie, Abhinav K Jain, Byron Hing Lung Lee, Sangeeta Goswami

Faculty, Staff and Student Publications

Mutations in epigenetic regulators are common in bladder cancer, yet their impact on therapeutic responses remains unclear. Here, we identify that loss-of-function mutations in KDM6A, a histone demethylase altered in about 26% of advanced bladder cancers, are associated with poor survival after cisplatin chemotherapy, whereas they correlate with improved outcomes with anti-PD-1 therapy. Using CRISPR-Cas9-engineered murine and human bladder cancer models, we show that KDM6A deficiency increases formation of extrachromosomal circular DNA carrying chemoresistance loci, promoting cisplatin resistance. In parallel, KDM6A loss impairs DNA repair and rewires tumor metabolism, reducing glycolysis and lactate output. This metabolic shift diminishes histone lactylation …

Glossary-Augmented Generative Ai For Enterprise Translation, Tanmay Kayande, Deep Raithatha, Akash Dambhare, Pooja Agrawal, Mohith P

Defensive Publications Series

Global enterprise operations can experience inefficiencies and service delays from language-siloed support queues, while generic machine translation tools may lack the context to handle enterprise-specific terminology. A system and method can facilitate multilingual communication by integrating a generative artificial intelligence model within enterprise workflow platforms, such as customer relationship management systems. The framework can programmatically retrieve a curated, enterprise-specific glossary and inject it into a translation prompt sent to the model. This technique grounds the model, instructing it to prioritize an organization's specific lexicon for a given translation. The approach can produce translations that are both linguistically fluent and terminologically …

Thermodynamic Stability Modulates Chaperone-Mediated Disaggregation Of Α-Synuclein Fibrils, Celia Fricke, Antonin Kunka, Rasmus K Norrild, Shuangyan Wang, Thi Lieu Dang, Jonas Folke, Mohammad Shahnawaz, Claudio Soto, Susana Aznar, Anne S Wentink, Bernd Bukau, Alexander K Buell

Faculty, Staff and Student Publications

Aggregation of the intrinsically disordered protein alpha-synuclein into amyloid fibrils and their subsequent intracellular accumulation are hallmark features of several neurodegenerative disorders, including Parkinson's disease, for which no curative treatments currently exist. In this study, we investigate the relationship between fibril morphology, thermodynamic stability, and susceptibility to disaggregation by the human chaperone system comprising HSP70, DNAJB1, and Apg2. By varying assembly conditions and incubation times, we generated alpha-synuclein fibrils with diverse morphological and biochemical properties, including a broad range of thermodynamic stabilities, which we quantified using a chemical depolymerization assay. The chaperone system effectively disaggregated three of the four fibril …

The Virtual Kitchen Challenge-Version 2: Validation Of A Digital Assessment Of Everyday Function In Older Adults, Marina Kaplan, Moira Mckniff, Stephanie M. Simone, Molly B. Tassoni, Katherine Hackett, Sophia Holmqvist, Rachel E. Mis, Kimberly Halberstadter, Riya Chaturvedi, Melissa Rosahl, Giuliana Vallecorsa, Mijail Serruya, Deborah A. G. Drabick, Takehiko Yamaguchi, Tania Giovannetti

Department of Medicine Faculty Papers

BACKGROUND: Conventional methods of functional assessment include subjective self- or informant report, which may be biased by personal characteristics, cognitive abilities, and lack of standardization (eg, influence of idiosyncratic task demands). Traditional performance-based assessments offer some advantages over self- or informant reports but are time-consuming to administer and score.

OBJECTIVE: This study aims to evaluate the validity and reliability of the Virtual Kitchen Challenge-Version 2 (VKC-2), an objective, standardized, and highly efficient alternative to current functional assessments for older adults across the spectrum of cognitive aging, from preclinical to mild dementia.

METHODS: A total of 236 community-dwelling, diverse older adults …

Harnessing Microbial Tools: Escherichia Coli As A Vehicle For Neuropeptide Functional Analysis In Caenorhabditis Elegans, Elizabeth M Diloreto, Shruti Shastry, Emily J Leptich, Douglas K Reilly, Rachel N Arey, Jagan Srinivasan

Faculty, Staff and Students Publications

Animals respond to changes in their environment and internal states via neuromodulation. Neuropeptides modulate neural circuits with flexibility because 1 gene can produce either multiple copies of the same neuropeptide or different neuropeptides. However, with this architectural complexity, the function of discrete and active neuropeptides is muddled. Here, we design a genetic tool that facilitates functional analysis of individual peptides. We engineered Escherichia coli bacteria to express active peptides, fed loss-of-function Caenorhabditis elegans, and rescued the activity of genes with varying lengths and functions: pdf-1, flp-3, ins-6, and ins-22. Some peptides were functionally redundant, while others exhibit unique and previously …

Spatially Resolved Integrative Analysis Of Transcriptomic And Metabolomic Changes In Tissue Injury Studies, Eleanor C Williams, Lovisa Franzén, Martina Olsson Lindvall, Gregory Hamm, Steven Oag, Muntasir Mamun Majumder, James Denholm, Azam Hamidinekoo, Javier Escudero Morlanes, Marco Vicari, Joakim Lundeberg, Laura Setyo, Trevor M Godfrey, Livia S Eberlin, Aleksandr Zakirov, Jorrit J Hornberg, Marianna Stamou, Patrik L Ståhl, Anna Ollerstam, Jennifer Y Tan, Irina Mohorianu

Faculty, Staff and Students Publications

Recent developments in spatially resolved -omics have enabled the joint study of gene expression, metabolite levels and tissue morphology, offering greater insights into biological pathways. Integrating these modalities from matched tissue sections to probe spatially-coordinated processes, however, remains challenging. Here we introduce MAGPIE, a framework for co-registering spatially resolved transcriptomics, metabolomics, and tissue morphology from the same or consecutive sections. We show MAGPIE's generalisability and scalability on spatial multi-omics data from multiple tissues, combining Visium with MALDI and DESI mass spectrometry imaging. MAGPIE was also applied to new multi-modal datasets generated with a specialised sampling strategy to characterise the metabolic …

Pathways, Outputs And Impact Of Nih-Supported Bioinformatics And Genomics Graduate Trainees In Africa, Daudi Jjingo, Andrew Walakira, Suhaila Hashim, Cisse Cheickna, Ronald Galiwango, Caleb Kibet, Florence N Kivunike, Gerald Mboowa, Fredrick Elishama Kakembo, Babajide Ayodele, Jean-Baka Domelevo Entfellner, Santie De Villiers, Karen Wambui, Segun Fatumo, Tinashe Chikowore, John Mukisa, Alfred Ssekagiri, Nicholas Bbosa, Julius Mulindwa, Samuel Kyobe, Mike Nsubuga, Grace Kebirungi, Eric Katagirya, Savannah Mwesigwa, Ibra Lujumba, Rogers Kamulegeya, Samuel Kirimunda, Stephen Kanyerezi, Shahiid Kiyaga, Ivan Sserwadda, Davis Kiberu, Bernard S Bagaya, Julius Okwir, Patricia Nabisubi, Grace Nabakooza, Mugume Twinamatsiko Atwine, Ricard Sserunjogi, Rolanda Julius, Mariam Quiñones, Meghan Mccarthy, Phillip Cruz, Karlynn Noble, Christopher J Whalen, Darrell Hurt, Maria Y Giovanni, Michael Tartakovsky, Deogratius Ssemwanga, John M Kitayimbwa, Steven J Reynolds, Christopher C Whalen, Andrew Kambugu, Neil A Hanchard, Li Jian, Peter Amoako-Yirenkyi, Graeme Mardon, I King Jordan, Samson Pandam Salifu, Mamadou Wele, Ezekiel Adebiyi, Jeffrey G Shaffer, Seydou Doumbia, David Patrick Kateete, Michelle Skelton, Nicola Mulder, Jonathan K Kayondo, Daniel Masiga, H3africa Consortium

Faculty, Staff and Students Publications

Global biomedical and health research is increasingly relying on genomic and computational approaches, largely driven by the increasing volumes of nucleic acid sequencing. Concurrently, epidemiological studies and clinical records are generating enormous amounts of data amenable to disease modeling, machine learning, and artificial intelligence techniques. Bioinformatics and data science expertise is therefore essential for improved population health. Accordingly, in 2012, the US National Institutes of Health (NIH) in partnership with the Wellcome Trust, and with support from the African Society for Human Genetics, initiated the H3Africa (Human Heredity and Health in Africa) consortium. One of its key goals was to …

Machine Learning-Based Multimodal Biomarkers Enable Accurate Diagnosis And Early Detection Of Pancreatic Ductal Adenocarcinoma, Tsung-Hung Yao, Warapen Treekitkarnmongkol, Nagireddy Putluri, Deivendran Sankaran, Tristian Nguyen, Seetharaman Balasenthil, Mark W Hurd, Meng Chen, Randall E Brand, Paul D Lampe, Abu Hena M Kamal, Vasanta Putluri, Tony Y Hu, Anirban Maitra, Eugene J Koay, Ann M Killary, Subrata Sen, Suprateek Kundu

Faculty, Staff and Students Publications

While there has been some progress on discovering clinically validated biomarkers for early detection in pancreatic ductal adenocarcinoma (PDAC), several challenges remain. Most approaches rely on single-modality biomarkers with limited sensitivity and/or specificity. Using data from a multicenter study with an age-matched cohort (n = 203 with healthy controls n = 46, pancreatitis controls n = 36, and diagnosed cases n = 121), we developed a machine learning approach integrating 2,096 microRNAs, 125 metabolites, and CA19-9. Our method performs unsupervised selection of an optimal subset of biomarkers with maximal discriminatory power for diagnosis and early detection. In training data, the …

Assessing The Effects Of Ehealth Literacy And The Area Deprivation Index On Barriers To Electronic Patient Portal Use For Orthopedic Surgery: Cross-Sectional Observational Study, Audrey Lynn Litvak, Nicholas Lin, Kelly Hynes, Jason Strelzow, Jeffrey G Stepan

2020-Current year OA Pubs

BACKGROUND: As electronic patient portals (EPPs) continue to gain popularity and systems transition to online tools for scheduling, communication, and telehealth, patients without access or skills to use these tools may be overlooked.

OBJECTIVE: This study analyzed patient and neighborhood-level factors, including eHealth literacy level and the Area Deprivation Index (ADI), that may limit EPP access for orthopedic surgery.

METHODS: A cross-sectional, survey-based study was performed at a single urban tertiary academic medical center in the United States across foot and ankle, hand and upper extremity, and orthopedic trauma subspecialty clinics from June 21, 2022, to August 12, 2022. Survey …

Editorial: Building Belonging Across Languages: Spanish-English Picturebooks In Conversation Construyendo Pertenencia Entre Lenguas: Libros Bilingües En Diálogo, Brenda Sarmiento-Quezada, Dafne Zanelli

First Opinions, Second Reactions

No abstract provided.

Examining The Impact Of Racial Microaggressions And Psychological Distress In Latine Individuals: A Focus On Ptsd, Anxiety, Depression, And Stress, Melanie Garcia, Yajairy Cabrales, Miguel A. Castano, Richard Chang, Gloria Wong-Padoongpatt

Spectra Undergraduate Research Journal

Latine individuals in the United States face distinct mental health challenges due to unique stressors, including systemic racism and discrimination. While research has established that racial microaggressions—such as daily slights, insults, and invalidations—negatively impact the psychological well-being of people of color, there remains limited scholarship specifically focused on Latine communities. This study examines different types of racial microaggressions—such as invisibility, criminality, and sexualization—as predictors of psychological distress among Latine individuals. A sample of 434 Latine participants completed measures assessing their experiences with racial microaggressions, as well as symptoms of depression, anxiety, stress, and trauma. Four multiple linear regression models were …