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Articles 20821 - 20850 of 1439316
Full-Text Articles in Entire DC Network
Intestinal Epithelial Tlr5 Signaling Promotes Barrier-Supportive Macrophages, Ming-Ting Tsai, Ryann Callaghan, Charles Ng, Lisette Peres-Tintin, Dean B Matthews, Nikketa Stanford, Karuna Ganesh, Mary K Estes, Gretchen E Diehl
Intestinal Epithelial Tlr5 Signaling Promotes Barrier-Supportive Macrophages, Ming-Ting Tsai, Ryann Callaghan, Charles Ng, Lisette Peres-Tintin, Dean B Matthews, Nikketa Stanford, Karuna Ganesh, Mary K Estes, Gretchen E Diehl
Faculty, Staff and Students Publications
Intestinal macrophages are essential for epithelial barrier repair. In homeostasis, macrophages are continuously replenished by recruitment of circulating CCR2+ monocytes into the intestinal lamina propria. This requires the commensal microbiota, however, the specific microbial factors and downstream host pathways that coordinate macrophage replenishment are inadequately understood. Here, we show that colonization with an E. coli isolate increased CCR2+ macrophages in the intestine and ameliorated pathology in a colitis model. Using human colonic organoids, we showed E. coli colonization induced CCL2 secretion by intestinal epithelial stem cells which promoted monocyte migration. In vivo, protection was abolished in the absence of epithelial …
Fyn-Saracatinib Complex Structure Reveals An Active State-Like Conformation, Hai Minh Ta, Banumathi Sankaran, Eric D Roush, Josephine C Ferreon, Allan Chris M Ferreon, Choel Kim
Fyn-Saracatinib Complex Structure Reveals An Active State-Like Conformation, Hai Minh Ta, Banumathi Sankaran, Eric D Roush, Josephine C Ferreon, Allan Chris M Ferreon, Choel Kim
Faculty, Staff and Students Publications
Fyn is a Src-family tyrosine kinase implicated in synaptic dysfunction and neuroinflammation across multiple neurodegenerative disorders, including Alzheimer's disease (AD) and Parkinson's disease (PD). Saracatinib (AZD0530) is a potent Src-family inhibitor that has been explored as a repurposed therapeutic; however, its clinical utility is limited by poor kinase selectivity caused by high sequence conservation within Src-family ATP-binding sites. Here, we combine surface plasmon resonance (SPR) and X-ray crystallography to define saracatinib recognition by the Fyn kinase domain (KD). SPR single-cycle kinetics shows that saracatinib binds the isolated Fyn KD and full-length Fyn with low-nanomolar affinity, whereas dasatinib binds with subnanomolar …
2020u_Uc02_Approved_Pm_Bs-Interdisciplinary-Studies-Curriculum-Changes-Revision1, Undergraduate Curriculum Council
2020u_Uc02_Approved_Pm_Bs-Interdisciplinary-Studies-Curriculum-Changes-Revision1, Undergraduate Curriculum Council
All Approved Curriculum
No abstract provided.
2020u_Uc01_Approved_Pm-Bgs-Curriculum-Changesrevision1, Undergraduate Curriculum Council
2020u_Uc01_Approved_Pm-Bgs-Curriculum-Changesrevision1, Undergraduate Curriculum Council
All Approved Curriculum
No abstract provided.
2019u_Nhp31_Approved_Cr_Cd-3402-Revision1, Undergraduate Curriculum Council
2019u_Nhp31_Approved_Cr_Cd-3402-Revision1, Undergraduate Curriculum Council
All Approved Curriculum
No abstract provided.
2019u_Nhp32_Approved_Cr_Cd-4502-Revision1, Undergraduate Curriculum Council
2019u_Nhp32_Approved_Cr_Cd-4502-Revision1, Undergraduate Curriculum Council
All Approved Curriculum
No abstract provided.
2020u_Lac77_Approved_Pm_Fye-In-Art-And-Graphic-Design-Majors, Undergraduate Curriculum Council
2020u_Lac77_Approved_Pm_Fye-In-Art-And-Graphic-Design-Majors, Undergraduate Curriculum Council
All Approved Curriculum
No abstract provided.
2020u_Lac65_Approved_Pm_Ba-Theatre-Curricular-Changes, Undergraduate Curriculum Council
2020u_Lac65_Approved_Pm_Ba-Theatre-Curricular-Changes, Undergraduate Curriculum Council
All Approved Curriculum
No abstract provided.
2020u_Lac20_Approved_Cr_Arth-430v-Studies-In-Art-History-Revision1, Undergraduate Curriculum Council
2020u_Lac20_Approved_Cr_Arth-430v-Studies-In-Art-History-Revision1, Undergraduate Curriculum Council
All Approved Curriculum
No abstract provided.
2019u_Lac127_Approved_Nc_Mus-2721-Jazz-Piano-I, Undergraduate Curriculum Council
2019u_Lac127_Approved_Nc_Mus-2721-Jazz-Piano-I, Undergraduate Curriculum Council
All Approved Curriculum
No abstract provided.
2020u_Lac79_Approved_Pm_Bfa-Graphic Design-Digital Design-Curriculum-Changes, Undergraduate Curriculum Council
2020u_Lac79_Approved_Pm_Bfa-Graphic Design-Digital Design-Curriculum-Changes, Undergraduate Curriculum Council
All Approved Curriculum
No abstract provided.
2020u_Lac69_Approved_Nc_Thea-4293-Theatre-History, Undergraduate Curriculum Council
2020u_Lac69_Approved_Nc_Thea-4293-Theatre-History, Undergraduate Curriculum Council
All Approved Curriculum
No abstract provided.
2020u_Lac11_Approved_Pm_Ba-Theatre-Design-Technology-Emphasis-Renaming, Undergraduate Curriculum Council
2020u_Lac11_Approved_Pm_Ba-Theatre-Design-Technology-Emphasis-Renaming, Undergraduate Curriculum Council
All Approved Curriculum
No abstract provided.
2019u_Lac128_Approved_Nc_Mus-2731-Jazz-Piano-Ii-Revision1, Undergraduate Curriculum Council
2019u_Lac128_Approved_Nc_Mus-2731-Jazz-Piano-Ii-Revision1, Undergraduate Curriculum Council
All Approved Curriculum
No abstract provided.
2019u_Lac126_Approved_Nc_Mus-2701-Improvisation-Ii, Undergraduate Curriculum Council
2019u_Lac126_Approved_Nc_Mus-2701-Improvisation-Ii, Undergraduate Curriculum Council
All Approved Curriculum
No abstract provided.
2019u_Lac122_Approved_Lon_New-Emphasis-Jazz-Studies-Ba-Music, Undergraduate Curriculum Council
2019u_Lac122_Approved_Lon_New-Emphasis-Jazz-Studies-Ba-Music, Undergraduate Curriculum Council
All Approved Curriculum
No abstract provided.
2019u_Lac123_Approved_Lon_New-Certificate-Jazz-Studies-Revision1, Undergraduate Curriculum Council
2019u_Lac123_Approved_Lon_New-Certificate-Jazz-Studies-Revision1, Undergraduate Curriculum Council
All Approved Curriculum
No abstract provided.
2020u_Ecs04_Approved_Lon_Electrical-Engineering-New-Minor-Revision1, Undergraduate Curriculum Council
2020u_Ecs04_Approved_Lon_Electrical-Engineering-New-Minor-Revision1, Undergraduate Curriculum Council
All Approved Curriculum
No abstract provided.
2020u_Ecs01_Approved_Lon_Technology-Name-Change-Revision2, Undergraduate Curriculum Council
2020u_Ecs01_Approved_Lon_Technology-Name-Change-Revision2, Undergraduate Curriculum Council
All Approved Curriculum
No abstract provided.
2020u_Ebs02_Approved_Cr_Ech-4063-Social-Foundations-Of-Education, Undergraduate Curriculum Council
2020u_Ebs02_Approved_Cr_Ech-4063-Social-Foundations-Of-Education, Undergraduate Curriculum Council
All Approved Curriculum
No abstract provided.
2020u_Ebs01_Approved_Cr_Ech-2003-Introduction-To-Instructional-Technology, Undergraduate Curriculum Council
2020u_Ebs01_Approved_Cr_Ech-2003-Introduction-To-Instructional-Technology, Undergraduate Curriculum Council
All Approved Curriculum
No abstract provided.
2020g_Lac22_Approved_Pm_Ma-And-Mse-English-Changes, Graduate Council
2020g_Lac22_Approved_Pm_Ma-And-Mse-English-Changes, Graduate Council
All Approved Curriculum
No abstract provided.
2020g_Lac23_Approved_Pm_Mse-English-Curriculum-Changes, Graduate Council
2020g_Lac23_Approved_Pm_Mse-English-Curriculum-Changes, Graduate Council
All Approved Curriculum
No abstract provided.
2020g_Lac21_Approved_Cr_Eng-6133-Theory-And-Methods-Of-Literary-Study, Graduate Council
2020g_Lac21_Approved_Cr_Eng-6133-Theory-And-Methods-Of-Literary-Study, Graduate Council
All Approved Curriculum
No abstract provided.
2019g_Lac13_Approved_Cr_Eng-6563-Teaching-Literature-In-The-Schools-Revision1, Graduate Council
2019g_Lac13_Approved_Cr_Eng-6563-Teaching-Literature-In-The-Schools-Revision1, Graduate Council
All Approved Curriculum
No abstract provided.
2019g_Lac14_Approved_Cr_Eng-6712-Preceptorship-In-Teaching-Composition-Revision1, Graduate Council
2019g_Lac14_Approved_Cr_Eng-6712-Preceptorship-In-Teaching-Composition-Revision1, Graduate Council
All Approved Curriculum
No abstract provided.
2019g_Lac12_Approved_Cr_Eng-6533-Teaching-Writing-In-The-Schools-Revision1, Graduate Council
2019g_Lac12_Approved_Cr_Eng-6533-Teaching-Writing-In-The-Schools-Revision1, Graduate Council
All Approved Curriculum
No abstract provided.
2020g_Ebs08_Approved_Cr_Rdng-7473-Theories-Of-Language-Acquisition, Graduate Council
2020g_Ebs08_Approved_Cr_Rdng-7473-Theories-Of-Language-Acquisition, Graduate Council
All Approved Curriculum
No abstract provided.
2019g_Ebs38_Approved_Nc_Coun-6703-Counseling-English-Language-Learners-In-The-School-Setting, Graduate Council
2019g_Ebs38_Approved_Nc_Coun-6703-Counseling-English-Language-Learners-In-The-School-Setting, Graduate Council
All Approved Curriculum
No abstract provided.
2021g_Nhp50_Approved_Nc_Otd-7103-Culturally-Competent-Practice-1, Graduate Council
2021g_Nhp50_Approved_Nc_Otd-7103-Culturally-Competent-Practice-1, Graduate Council
All Approved Curriculum
No abstract provided.