Digital Commons Network^™

Hybrid Sensing For Near-Earth Space Domain Awareness: Leveraging Space-Based Assets For Augmenting Optical Ground Observations, Smriti Nandan Paul, Hang Woon Lee

Mechanical and Aerospace Engineering Faculty Research & Creative Works

Because of recent advancements in space technologies, easier and more economical access to space, and an increase in commercial interests, the near-Earth space environment has witnessed an exploding number of objects being put into orbit. In particular, the low Earth orbit (LEO) region is at an increased risk of orbital collisions from large satellite constellation projects. Thus, monitoring LEO objects for space domain awareness and space traffic management has become increasingly imperative. In this paper, we use the concept of limited-CDF (cumulative distribution function) surface and mutual information for designing sensor tasking algorithms focusing on regular observation of known catalog …

Generative Artificial Intelligence In Aircraft Design Optimization, Xiaosong Du

Mechanical and Aerospace Engineering Faculty Research & Creative Works

Aircraft design optimization is essential for improving aircraft performance (such as reduced fuel consumption and lowered noise), which leads to more efficient, sustainable, and affordable aircraft. Conventional aircraft design adopts physics-based simulation models, but iteratively evaluating simulation models is computationally intensive, or even practically impossible. Meanwhile, artificial intelligence (AI) emerges as a revolutionary game changer in the modern engineering industry, including aircraft design optimization. Generative AI (genAI), one of the groundbreaking AI methods, has been advancing aircraft design optimization from various aspects, including intelligent parameterization, predictive modeling, training facilitation, and constraints handling. However, there is a lack of a review …

Machine Learning In Peak Demand Forecasting: Foundations, Trends, And Insights, Shuang Dai, Fanlin Meng, Hongsheng Dai, Qian Wang, Xizhong Chen, Wenlei Bai, Peizhi Shi, Richard Allmendinger, Yuchen Zhang, Jian Liu

Electrical and Computer Engineering Faculty Research & Creative Works

Peak demand forecasting involves predicting the maximum electricity demand within a specific period, which plays a key role in maintaining the efficiency and stability of power systems. The rapid evolution of power systems, driven by advanced metering infrastructure, local energy applications such as electric vehicles, and the increasing adoption of intermittent renewable energy, has introduced greater randomness and reduced predictability in peak demand. Given the pressing need to address more diverse implementation requirements across different contexts, accurate and reliable peak demand forecasting has become increasingly important. To the best of our knowledge, this study is the first to provide a …

Efficient Function Orchestration For Large Language Models, Xiaoxia Liu, Peng Di, Cong Li, Jun Sun, Jingyi Wang

Research Collection School Of Computing and Information Systems

Function calling is a fundamental capability of today's large language models, but sequential function calling posed efficiency problems. Recent studies have proposed to request function calls with parallelism support in order to alleviate this issue. However, they either delegate the concurrent function calls to users for execution which are conversely executed sequentially, or overlook the relations among various function calls, rending limited efficiency. This paper introduces LLMOrch, an advanced framework for automated, parallel function calling in large language models. The key principle behind LLMOrch is to identify an available processor to execute a function call while preventing any single processor …

Constrained Pricing In Logit-Based Revenue Management, Qian Shao, Tien Mai, Shih-Fen Cheng

Research Collection School Of Computing and Information Systems

We consider a dynamic pricing problem in network revenue management in which customer behavior is predicted by a choice model, that is, the multinomial logit model. The problem, even in the static setting (i.e., customer demand remains unchanged over time), is highly nonconcave in prices. Existing studies mostly rely on the observation that the objective function is concave in terms of purchasing probabilities, implying that the static pricing problem with linear constraints on purchasing probabilities can be efficiently solved. However, this approach is limited in handling constraints on prices, noting that such constraints could be highly relevant in some real …

Prisrv+: Privacy And Usability-Enhanced Wireless Service Discovery With Fast And Expressive Matchmaking Encryption, Yang Yang, Guomin Yang, Yingjiu Li, Pengfei Wu, Rui Shi, Minming Huang, Jian Weng, Hwee Hwa Pang, Deng, Robert H.

Research Collection School Of Computing and Information Systems

The evolution of decentralized identity (DID) and self-sovereign identity (SSI) frameworks, as endorsed by W3C Verifiable Credentials (VC) and eIDAS 2.0, underscores the need for secure, efficient, and privacy-preserving credential management. However, existing credential systems often depend on centralized issuers, lack efficient aggregation mechanisms, or fail to ensure unlinkability across authentication sessions. To address these challenges, we propose DISC (Decentralized Identity System with Self-Sovereign Credential Aggregation), a novel credential system that enables multi-authority credential issuance, user-controlled credential aggregation, and unlinkable authentication. DISC allows users to aggregate credentials from multiple issuers while maintaining constant-size authentication tokens and supporting batch verification for …

Prompt Tuning Without Labeled Samples For Zero-Shot Node Classification In Text-Attributed Graphs, Sethupathy Parameswaran, Suresh Sundaram, Yuan Fang

Research Collection School Of Computing and Information Systems

Node classification is a fundamental problem in information retrieval with many real-world applications, such as community detection in social networks, grouping articles published online and product categorization in e-commerce. Zero-shot node classification in text-attributed graphs (TAGs) presents a significant challenge, particularly due to the absence of labeled data. In this paper, we propose a novel Zero-shot Prompt Tuning (ZPT) framework to address this problem by leveraging a Universal Bimodal Conditional Generator (UBCG). Our approach begins with pre-training a graph-language model to capture both the graph structure and the associated textual descriptions of each node. Following this, a conditional generative model …

Mm-Attackg: A Multimodal Approach To Attack Graph Construction With Large Language Models, Yongheng Zhang, Xinyun Zhao, Yunshan Ma, Haokai Ma, Yingxiao Guan, Guozheng Yang, Yuliang Lu, Xiang Wang

Research Collection School Of Computing and Information Systems

Cyber Threat Intelligence (CTI) parsing aims to extract key threat information from massive data, transform it into actionable intelligence, enhance threat detection and defense efficiency, including attack graph construction, intelligence fusion, and indicator extraction. Among these research topics, Attack Graph Construction (AGC) is essential for visualizing and understanding the potential attack paths of threat events from CTI reports. Existing approaches primarily construct the attack graphs purely from the textual data to reveal the logical threat relationships between entities within the attack behavioral sequence. However, they typically overlook the specific threat information inherent in visual modalities, which preserves key threat details …

Roadmap To Implement Statewide Veterans Coordinated Care In New Mexico, Nosa Akol, Zachary Bridgewater, Vincent Delsignore, Emily Graham, Mary Rachel Keville

Institute for Veterans and Military Families

The New Mexico State Legislature is interested in building a statewide coordinated care network to better connect veterans and their families to service. This document translates community input into an actionable roadmap for implementation. This outlines key activities, objectives, and milestones across each phase of the project--designed to guide state leaders and implementation partners from design to launch to steady state operations.

Reflections On Linear B (Part 14) – Sign 76 (With Two Parallel Wavy Lines Pronounced /Ra/); Possible Derivation From The River Traveled Nightly By The Sun God Ra., Gerald Leonard Cohen

Arts, Languages and Philosophy Faculty Research & Creative Works

This article suggests that the two parallel wavy lines in Linear B sign 76 depict the river traveled nightly by the Egyptian sun god Ra. Also:

1. The Egyptian influence was likely exerted already on the Linear A and Cretan hieroglyphic antecedents of Linear B sign 76.

2. Variants of Linear B sign 76 contain a horizontal line across the two wavy vertical lines. The present article suggests the horizontal line might indicate one of the river’s twelve gates that Ra had to navigate through in his nightly journey.

3. But the single line for that one gate was likely …

Recommended Best Practices For Construct-Centered Adaptation Of The Harmonized Cognitive Assessment Protocol, Emily M. Briceño, Darina T. Bassil, Pranali Khobragade, Anthony Ngugi, Martine El Bejjani, Eric Ochieng, Silvia Mejia-Arango, Salima Douhou, Kazione Kulisewa

School of Medicine Publications

Objectives: The Harmonized Cognitive Assessment Protocol (HCAP) neuropsychological assessment approach aims to support the collection of harmonizable data on cognitive function for cross-national cognitive aging and dementia research. As the measurement of cognition is sensitive to differences in contextual, cultural, educational, linguistic, social, and other factors that may influence cognitive test performance, HCAP requires adaptation to be appropriate for the contexts in which it is administered. We aim to provide methodological recommendations for the adaptation and implementation of the HCAP and other cognitive data collection tools in novel settings.

Methods: We drew from existing guidelines on cross-cultural psychological test adaptation …

Artificial Intelligence In Cardiology: An Updated Systematic Review With Ethical Considerations And Challenges In Implementing Artificial Intelligence Models, Dev Patel, Reshmitha Kantamneni, Jabez David John, Tirath Patel, Arnesh Shukla, Ayesha Salma, Nikhilesh Anand

School of Medicine Publications

The integration of artificial intelligence (AI) in cardiovascular medicine presents a transformative opportunity to enhance diagnostic accuracy and improve patient outcomes. This systematic review evaluates the impact of AI on cardiovascular diagnostics with a focus on its ability to surpass traditional methods in accuracy, efficiency, and predictive capabilities. Machine learning and deep learning have demonstrated significant advancements in areas such as echocardiography, electrocardiography, computed tomography angiography, and predictive analytics.

AI algorithms have demonstrated superior performance in identifying subtle patterns and anomalies. Additionally, AI has shown promise in predictive analytics, forecasting disease progression and tailoring treatment plans, thereby improving patient outcomes. …

Electric Dipole Forbidden, Quadrupole Allowed Transitions In The Pure Rotational Spectrum Of Cyclopropylchloromethyldifluorosilane, Alexander R. Davies, Abanob G. Hanna, Alma Lutas, Gamil A. Guirgis, S. A. Cooke, Garry S. Grubbs

Chemistry Faculty Research & Creative Works

In a recent publication, some electric dipole forbidden, quadrupole allowed ΔJ = +2 and x-type transitions were observed in the chirped-pulse Fourier transform microwave spectrum of two conformations of cyclopropylchloromethyldifluorosilane. Many of these transitions arise from a handful of mixed states and mechanisms are proposed through which these transitions become weakly allowed. Observations of electric dipole forbidden, quadrupole allowed transitions in rotational spectra are unusual for molecules which contain a chlorine nucleus owing to the small quadrupole moment of ³⁵Cl and ³⁷Cl; thus, we believe we are the first to observe x-type transitions arising from perturbations caused by …

Full Core Fuel Burnup Assessment Of The Itu Triga Mark Ii Research Reactor Using Gamma Spectroscopy, Z. Boduroglu, A. Kaya, O. Erbay, I. A. Reyhancan, M. S. Kiziltas, T. Akyurek

Nuclear Engineering and Radiation Science Faculty Research & Creative Works

This study investigates the burnup distribution of fuel elements in the ITU TRIGA Mark II research reactor core through gamma spectroscopy using¹³⁷Cs as a burnup indicator. Non-Destructive Assay (NDA) techniques were employed to analyze fuel depletion, utilizing a specialized fuel investigation system installed above the reactor pool. The results indicate that the highest burnup values, exceeding 5 %, were concentrated in the inner core rings (B and C) due to intense neutron flux exposure, while the outer rings (D, E, F) exhibited lower burnup levels. To address this asymmetric distribution, a proposed fuel reshuffling strategy was analyzed, aiming …

Originalism, Official History, And Perspectives Versus Methodologies, Keith N. Hylton

Faculty Scholarship

This paper addresses a well-worn topic: originalism, the theory that judges should interpret the U.S. Constitution in a manner consistent with the intent of its framers. I am interested in the real-world effects of originalism. The primary effect advanced by originalists is the tendency of the approach to constrain the discretion of judges. However, I identify another effect of originalism: the creation of official histories, a practice that imposes a hidden tax on society. Another question I consider is whether originalism should be considered a methodology of analyzing the law or a perspective on the law; I argue that originalism …

Flare Guns And Trauma: Patterns, Severity, And Clinical Implications From Case And National Surveillance Data, Ramsay Hafer, Andrew Huff, Lara Phillips

Department of Emergency Medicine Faculty Papers

Flare guns are pyrotechnic devices capable of causing serious injury due to high-temperature combustion and projectile discharge. Though intended for signaling in maritime or wilderness settings, improper use can result in trauma patterns distinct from those seen with typical burns or fireworks. Despite their severity, flare gun injuries remain underreported and poorly characterized. We conducted a scoping review of PubMed, Scopus, and Ovid to identify 12 case reports involving 13 patients, and reviewed US National Electronic Injury Surveillance System records from 2015 to 2024, identifying 18 flare gun-specific injuries for a combined total of 31 injuries. Demographic, injury mechanism, body …

Recurrent Miller Fisher Syndrome: A Case Report, Larry Vernier, Griffin B. Gilmore, Kelsey Van Housen, Xiao C. Zhang

Department of Emergency Medicine Faculty Papers

INTRODUCTION: Guillain-Barré syndrome can manifest with progressive paralysis, requiring careful monitoring and treatment with steroids or intravenous (IV) immunoglobin. While this disease can be devastating and require intensive care unit level of care, there are few incidences of relapses.

CASE REPORT: A 67-year-old man with a past medical history of Miller Fisher syndrome variant of Guillain-Barré syndrome, with complete recovery, presented to the emergency department (ED) with ataxia, ophthalmoplegia, dysphonia, and ambulatory dysfunction. The patient noticed his neurologic symptoms after waking up, and he presented to the ED with physical examination positive for difficulty with upward gaze, mild right lower …

Effect Of Heat Stress On Jejunal Epithelial Barrier Integrity In Broilers Divergently Selected For High- And Low-Water Efficiency, Elizabeth S. Greene, Sara Orlowski, Sami Dridi

Poultry Science Faculty Publications and Presentations

Drought and water scarcity, exacerbated by global warming, are enormous threats to global food sustainability and security. Poultry, in particular, are highly impacted by adverse environmental stressors. As nutrient absorption and intestinal integrity are critical for growth and performance, understanding the impact on the broiler gastrointestinal tract is highly relevant. Here, we examined the effect of chronic cyclic heat stress (HS) on the jejunal expression profile of tight-junction, gap-junction, adherens, and desmosome genes in the 4th generation of broiler lines divergently selected for low (LWE)- and high-water efficiency (HWE). Male HWE and LWE broilers (n = 240/line) were allotted to …

The Case For Ai Authorship In Copyright Law, Cheng Lim Saw, Duncan Lim

Research Collection Yong Pung How School Of Law

Today, with generative AI, literary and artistic works can be created almost effortlessly. There is at present intense debate as to whether works generated by AI – broadly categorised as “AI-assisted” and “AI-generated” works – ought to attract copyright protection. AI-assisted works are those that involve some degree of human intervention. Where AI-generated works are concerned, however, such works are created autonomously by the AI itself with minimal (de minimis) input from an identifiable human being. Presently, it is generally accepted that AI-generated works do not attract copyright protection for want of a human author. This article examines whether it …

Reflections On Judicial Supervision Of Prosecutorial Powers, Benjamin Joshua Ong

Research Collection Yong Pung How School Of Law

The courts occasionally claim that the limits to the power to prosecute are different from the limits to other executive powers. They say that prosecutorial decisions are subject to judicial review on a reduced set of grounds compared to other executive decisions. I have previously argued that this approach is wrong, and aim to elaborate on the argument in this blog post. The focus will be on the laws of the UK and of Singapore, but it is hoped that the reflections here will be of some use in other common-law jurisdictions as well.

Use Of Hybrid Versus Video-Only Teledermatology Varies By Condition: A Cross-Sectional Study Of 2064 Encounters, Jacqueline Penn, Kathryn Achuck, Christine Deng, Richard W. Hass, Elizabeth Jones

Department of Medicine Faculty Papers

No abstract provided.

One-Step Purification Of A Bioactive Pak1-Derived Peptide, Djamali Muhoza, Emily P. Esquivel, Stacy R. Hunter, Pateince S. Okoto, Thallapuranam K.S. Kumar, Paul D. Adams

Chemistry & Biochemistry Faculty Publications and Presentations

The serine/threonine kinase PAK1 serves as a mediator of cytoskeletal reorganization and cancer-related signaling downstream of the small GTPases. Due to the challenges in purifying PAK1 complexes, a 46-residue peptide from PAK1, is widely used to study PAK1-Cdc42 signaling. Traditionally, this purification involved multi-step chromatography of recombinant GST-PBD46 complexes, yielding approximately 1 mg per 1.5 L culture. In this study, a 30 min heat treatment step after thrombin cleavage was used to precipitate GST while leaving pure PBD46 in solution. This step eliminated the need for further affinity and size-exclusion chromatography steps. This improved protocol produces proteins with a 6.5-fold …

Cleavage And Polyadenylation Specificity Factor Subunit 5 Regulates Pulmonary Artery Smooth Muscle Expansion And Hypoxic Response, Scott D Collum, Lisha Zhu, Tingting W Mills, Rene Girard, Jamie Tran, Tinne C J Mertens, Cory Wilson, Nancy Wareing, Erik E Suarez, Howard J Huang, Rahat Hussain, Bindu Akkanti, Wenjin J Zheng, Hari K Yalamanchili, Bela Patel, Eric J Wagner, Sandeep Agarwal, Harry Karmouty-Quintana

Faculty, Staff and Student Publications

Pulmonary hypertension (PH) is a fatal condition that affects individuals with systemic sclerosis (SSc), a multiorgan fibrotic disease with limited treatment options. A central feature of PH is vascular remodeling, defined by the narrowing of the arteriole lumen due to cell proliferation and extracellular matrix deposition. Herein, we identify a central mechanism that can regulate multiple transcripts important for vascular remodeling. The highlight of our study is the demonstration that reduced pulmonary artery smooth muscle (PASMC) Nudt21, which codes for the RNA binding protein Cleavage and Polyadenylation Specificity Factor Subunit 5 (CPSF5) The, known to regulate alternative polyadenylation, results …

Faculty List

Journal of Dispute Resolution

No abstract provided.

The Sport Publication Observational Research Tool (Sport): An Objective Tool To Score The Methodological Quality Of Observational Clinical Sports Medicine Research, Andrew W Kuhn, Paul M Inclan, Ameer A Haider, Michele N Christy, Robert Brophy, Matthew Smith, Matthew J Matava, Et Al.

2020-Current year OA Pubs

BACKGROUND: A critical component of conducting systematic reviews or meta-analyses is assessing the methodological quality and bias of included studies. Several methodological quality assessment tools have been developed; however, these tools may not be relevant to observational sports medicine research, which carries numerous unique nuances and biases.

PURPOSE: To develop the Sport Publication Observational Research Tool (SPORT), which evaluates and scores the methodological quality of observational sports medicine research.

STUDY DESIGN: Consensus statement.

METHODS: SPORT was developed through a modified Delphi approach involving members from the Herodicus Society and The FORUM. All active members were invited to participate in the …

Bet Inhibitor-Based Combinations Targeting Novel Dependencies In Mecom-Rearranged (R) Aml, Christine E Birdwell, Warren Fiskus, Christopher P Mill, Tapan M Kadia, Naval Daver, Courtney D Dinardo, Koji Sasaki, John A Davis, Kaberi Das, Hanxi Hou, Antrix Jain, Anna Malovannaya, Lauren B Flores, Rasoul Pourebrahim, Selina Yuan, Xiaoping Su, Michele Ceribelli, Kapil N Bhalla

Faculty, Staff and Student Publications

MECOM rearrangement in AML involves either inv(3)(q21;q26.2) or t(3;3)(q21;q26.2), where the dislocated GATA2 enhancer drives overexpression of the transcriptional regulator EVI1, causes concomitant GATA2 repression, and promotes AML progression, aggressive phenotype and therapy refractoriness. Treatment with BET protein inhibitor (BETi) induces in vitro and in vivo efficacy in MECOM-r AML cells. Utilizing an unbiased, high-throughput drug screen, focused on mechanistically-annotated drugs, we identified BRD4, PIK3CA, mTOR, BCL-xL and XIAP as dependencies in the MECOM-r AML cells. Monotherapy with mivebresib (BETi), dactolisib (PI3K/mTORi) and LCL161 (IAPi) dose-dependently induced greater lethality in PD MECOM-r versus non-MECOM-r AML cells. RNA-Seq and/or mass spectrometry …

Lessons Learned In A Data Linkage Project On Fatal Drowning, Rohit P Shenoi, Ned Levine, Elizabeth A Camp, Linh Nguyen, Sandra Mckay, Shaila Zaman

Faculty, Staff and Student Publications

Background: Drowning is the leading cause of death in US children 1-4 years old. The epidemiology of drowning at a regional level is understudied because no single data source provides complete information on persons who drown. Probabilistic data linkage is a novel way of studying the epidemiology of drowning. This study aimed to document the lessons learned during the linkage process.

Methods: This was a cross-sectional study of persons of all ages who died from unintentional drowning in metropolitan Houston from 2016 to 2022. We describe the lessons learned during the project planning and execution phases which pertained to data …

Unravelling The Molecular Mechanisms Causal To Type 2 Diabetes Across Global Populations And Disease-Relevant Tissues, Ozvan Bocher, Ana Luiza Arruda, Satoshi Yoshiji, Chi Zhao, Alicia Huerta-Chagoya, Chen-Yang Su, Xianyong Yin, Davis Cammann, Henry J Taylor, Jingchun Chen, Ken Suzuki, Ravi Mandla, Ta-Yu Yang, Fumihiko Matsuda, Josep M Mercader, Jason Flannick, James B Meigs, Alexis C Wood, Marijana Vujkovic, Benjamin F Voight, Cassandra N Spracklen, Jerome I Rotter, Andrew P Morris, Eleftheria Zeggini

Children’s Nutrition Research Center Staff Publications

Type 2 diabetes (T2D) is a prevalent disease arising from complex molecular mechanisms. Here we leverage T2D genetic associations to identify causal molecular mechanisms in an ancestry-aware and tissue-aware manner. Using two-sample Mendelian randomization corroborated by colocalization across four global ancestries, we analyse 20,307 gene and 1,630 protein expression levels using blood-derived cis-quantitative trait loci (QTLs). We detect causal effects of genetically predicted levels of 335 genes and 46 proteins on T2D risk, with 16.4% and 50% replication in independent cohorts, respectively. Using gene expression cis-QTLs derived from seven T2D-relevant tissues, we identify causal links between the expression of 676 …

Differentiating Between Bk Activation And Potentiation By Vanzacaftor Enantiomers, Nathalie Baumlin, Frank T Horrigan, Stefan H Bossmann, Matthias Salathe

Faculty, Staff and Students Publications

No abstract provided.

Purpuric Pityriasis Rosea In A 7-Year-Old Girl: A Rare Variant With Generalized Involvement, Ying-Ying Qian, Ya-Fen Wu, Ting Zhang, Ji-Bing Li, Si-Yuan Song, Wei Li

Faculty, Staff and Students Publications

A 7-year-old girl presented with a 10-day history of generalized purpura and petechiae. The eruption began with a solitary violaceous macule on the trunk and progressed within 1 week to multiple oval and round dark-red to violaceous purpuric macules, ecchymoses, and petechiae affecting the face, trunk, and extremities. Lesions were distributed parallel to skin cleavage lines with a characteristic “Christmas-tree” pattern on the back (Fig 1). No oropharyngeal lesions were noted on examination, and the patient denied sore throat or oral discomfort. She reported no pruritus, pain, fever, or systemic symptoms.