Digital Commons Network^™

Targeted Genome Sequencing Identifies Multiple Rare Variants In Caveolin-1 Associated With Obstructive Sleep Apnea, Jingjing Liang, Heming Wang, Brian E Cade, Nuzulul Kurniansyah, Karen Y He, Jiwon Lee, Scott A Sands, Jennifer A Brody, Han Chen, Daniel J Gottlieb, Daniel S Evans, Xiuqing Guo, Sina A Gharib, Lauren Hale, David R Hillman, Pamela L Lutsey, Sutapa Mukherjee, Heather M Ochs-Balcom, Lyle J Palmer, Shaun Purcell, Richa Saxena, Sanjay R Patel, Katie L Stone, Gregory J Tranah, Eric Boerwinkle, Xihong Lin, Yongmei Liu, Bruce M Psaty, Ramachandran S Vasan, Ani Manichaikul, Stephen S Rich, Jerome I Rotter, Tamar Sofer, Susan Redline, Xiaofeng Zhu

Faculty, Staff and Students Publications

Rationale: Obstructive sleep apnea (OSA) is a common disorder associated with increased risk for cardiovascular disease, diabetes, and premature mortality. There is strong clinical and epidemiologic evidence supporting the importance of genetic factors influencing OSA but limited data implicating specific genes.

Objectives: To search for rare variants contributing to OSA severity.

Methods: Leveraging high-depth genomic sequencing data from the NHLBI Trans-Omics for Precision Medicine (TOPMed) program and imputed genotype data from multiple population-based studies, we performed linkage analysis in the CFS (Cleveland Family Study), followed by multistage gene-based association analyses in independent cohorts for apnea-hypopnea index (AHI) in a total …

Gene Therapy Knockdown Of Hippo Signaling Resolves Arrhythmic Events In Pigs After Myocardial Infarction, Sui Zhang, Shijie Liu, John P Leach, Ke Li, Emerson C Perin, James F Martin

Faculty, Staff and Students Publications

No abstract provided.

Policy Considerations That Support Equitable Access To Responsible, Accountable, Safe, And Ethical Uses Of Psychedelic Medicines, Sean J Belouin, Lynnette A Averill, Jack E Henningfield, Stephen N Xenakis, Ingrid Donato, Charles S Grob, Ann Berger, Veronica Magar, Alicia L Danforth, Brian T Anderson

Faculty, Staff and Students Publications

There is mounting evidence suggesting psychedelic and entactogen medicines (namely psilocybin and 3,4-methylenedioxymethamphetamine [MDMA]), in conjunction with proper psychosocial support, hold the potential to provide safe, rapid acting, and robust clinical improvements with durable effects. In the US, both psilocybin and MDMA have been granted Breakthrough Therapy designations by the US Food and Drug Administration and may potentially receive full FDA approval with similar regulatory considerations occurring in multiple countries. At the same time, regulatory changes are poised to increase access to legal or decriminalized psychedelic use in various non-medical settings. This review provides a brief discussion on the historical …

A, B, C'S Of Trk Receptors And Their Ligands In Ocular Repair, Akash Gupta, Jeremias G Galletti, Zhiyuan Yu, Kevin Burgess, Cintia S De Paiva

Faculty, Staff and Students Publications

Neurotrophins are a family of closely related secreted proteins that promote differentiation, development, and survival of neurons, which include nerve growth factor (NGF), brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4. All neurotrophins signal through tropomyosin receptor kinases (TrkA, TrkB, and TrkC) which are more selective to NGF, brain-derived neurotrophic factor, and neurotrophin-3, respectively. NGF is the most studied neurotrophin in the ocular surface and a human recombinant NGF has reached clinics, having been approved to treat neurotrophic keratitis. Brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4 are less studied neurotrophins in the ocular surface, even though brain-derived neurotrophic factor is well characterized in …

The Impact Of Murals On Traffic Safety: A Behavior And Crash Analysis, Maria Cecelia Cruz

Civil Engineering ETDs

ABSTRACT

This research analyzed changes in motor vehicle volumes and motor vehicle speeds after the installation of an intersection mural in Albuquerque, NM and changes in crash frequency after mural installations in Philadelphia, PA. Data was collected manually on site for the Albuquerque study and secondary data – including installation dates and physical characteristics – were used for the Philadelphia crash analyses. Statistics were computed to determine trends in motor vehicle speeds and volumes relative to the Albuquerque mural installation. A geographic information system (GIS) spatial analysis and t-test statistical analyses were used to determine which Philadelphia murals saw significant …

Techno-Economic Analysis Of Atmospheric Water Harvesting Across Climates, Natalie Gayoso

Civil Engineering ETDs

Drinking water scarcity is a global challenge as ground water and surface water availability diminishes. The atmosphere is an alternative freshwater reservoir that has universal availability and an abundance of water within the air. This makes the atmosphere a great source to capture drinking water. In order to effectively perform Atmospheric Water Harvesting (AWH) we need to 1) understand how different climate regions (e.g., arid, temperate, and tropical) drive the amount of water being produced, and 2) determine the cost to purchase, operate, and power AWH. This research pairs thermodynamics with Techno-Economic Analysis, a method of analyzing the economic performance …

¿Cuál Es La Potencial Influencia De Los Juegos De Rol En La Construcción De Relaciones Interpersonales En Niños Y Niñas?, Maria J. Espinosa Chueca

Journal of Roleplaying Studies and STEAM

ESPAÑOL

Los juegos de rol existen hace ya más de 50 años; pero, su impacto y beneficios en el desarrollo del niño no son valorados y/o reconocidos. Por ese motivo, la presente investigación argumenta que los juegos de rol pueden influir en la construcción de las relaciones interpersonales en niños. Mediante el análisis teórico, se ha buscado en el capítulo 1analizar desarrollo de los juegos de rol; explicando -mediante un marco conceptual debidamente articulado- las motivaciones detrás del juego, para, luego, poder discutir la importancia y necesidad de los juegos. Este estudio concluye que los juegos de rol pueden brindar …

Narración Colectiva, Horizontes De Interpretación Y Subjetividad: Los Juegos De Rol Como Mecanismos De Construcción De Subjetividades, Juan M. Díaz De La Torre

Journal of Roleplaying Studies and STEAM

ESPAÑOL

La presente propuesta busca establecer que, por medio de la narración y la construcción de un relato colectivo, el cual acontece en un juego de rol; se gesta una (inter)subjetividad compartida entre los miembros de los juegos de rol. Esta última entendida como la estructura que permite organizar sentimientos, emociones, percepciones e ideas de los sujetos sociales, en este caso, los jugadores/narradores.

Es decir, hay una estructura organizativa interior que se genera en la interacción por medio del relato durante el juego. De esta forma, el relato/juego, se vuelve un mecanismo de construcción de subjetividades que es interiorizada por …

Los Juegos De Rol Como Apoyo Para El Desarrollo De Narrativas Literarias De Fantasía Y Ciencia Ficción, Ricardo Victoria-Uribe, Nazario Robles-Bastida

Journal of Roleplaying Studies and STEAM

ESPAÑOL

El ‘storytelling’ o la narrativa, al igual que el juego, han formado parte de la civilización humana desde tiempos inmemoriales. Ambos han tenido como función ayudar al desarrollo psicológico y cultural de los participantes, así como al desarrollo de historias que transmiten una serie de creencias, valores, conocimientos y filosofías. A finales del Siglo XX, se dio origen a una transversalidad entre juegos y narrativa, cuando obras como las del afamado Tolkien, Conan el Bárbaro de Robert E. Howard y ‎Fafhrd & the Gray Mouser de Frietz Leiber, entre otras, inspiran la creación de los primeros juegos de …

Gabbard V. Madison Local School Dist. Bd. Of Edn. 179 N.E.3d 1169 (2021), Daniel W. Gudorf

Ohio Northern University Law Review

No abstract provided.

No Means No: A Constitutional Challenge To The Forced Blood Draw Provision Of Ohio’S Implied Consent Statute, Justin Hill

Ohio Northern University Law Review

No abstract provided.

The Conquest Of Milk: The Rise Of Lactase Persistence And The Fall Of Scandinavian Hunter-Gatherers, Nicholas Mays

James Madison Undergraduate Research Journal (JMURJ)

Over half of the global human population suffers from lactase nonpersistence, a condition marked by losing the ability to digest lactose after infancy. However, a minority of the global population, primarily located in Central and Northern Europe, has a genetic mutation that results in lactase persistence, which is the continued ability to process lactose after infancy. This interdisciplinary analysis blends archaeology, cultural anthropology, evolutionary biology, and archaeogenetics to explore the origin and rise of lactase persistence in Europe and its contribution to the end of hunter-gatherer societies in Scandinavia. Furthermore, the paper uses gene-culture coevolutionary theory to argue that lactase …

“…And I Thought That Was A Queer Thing To Do”: Transmasculine Identity In The Lokasenna, Tevye J. Schmidt

The Confluence

This paper seeks to explain the viewing of Loki through a lens of transmasculine identity, focusing on the ways in which gender expression and identity were viewed in Scandinavia during the Middle Ages. The current scholarship on Loki and gender expression, specifically in his interactions with the other gods in the Lokasenna, suggests a reading that is misogynistic on Loki’s part. This reading and translation also suggest homophobia and transphobia from Odin. This paper argues that these translations lack the nuance that a reading of Loki as transmasculine brings, and that this reading is important in breaking down modern …

The Role Of Ethics And Morality In Law: Similarities Anddifferences, Haxhi Xhemajli

Ohio Northern University Law Review

No abstract provided.

Is Information Property? Distinctive Genetic Information Has Ananswer, Kumiko Kitaoka

Ohio Northern University Law Review

No abstract provided.

The Nitrogen Dynamics Of Deer Cave, Sarawak, And The Role Of Bat Caves As Biogeochemical Sinks In Tropical Moist Forests., Joyce Lundberg, Donald A. Mcfarlane, Guy Van Rentergem

International Journal of Speleology

A better understanding of the role of bat caves as nitrogen sinks in tropical moist forest ecosystems can be expected to shed light on regional and spatial variability in nutrient recycling studies. We measured the nitrogen flux (in air and water) associated with a very large Chaerephon plicata bat colony in Deer Cave, Borneo, in the process generating a new, quantitative, estimate of the total bat population (774,828 ±48,320), and the first detailed modelling of an ammonia plume in a cave. Long-term storage of N does not occur in this wet cave. Our final budget numbers indicate that, of the …

Production-Grade Online Speech Recognition For Low-Resource Languages, Sylvain Le Groux, Zili Huang

Defensive Publications Series

Techniques are provided for speech recognition in real-time with a semi-supervised model based on Wav2vec2.0. Only minimal training data is required, thereby enabling service of under-represented/low resource languages at a quality level comparable to more widely available languages.

Jerry Wood Hill Papers, 1959-2014, Jerry Wood Hill

Center for Restoration Studies Archives, Manuscripts and Personal Papers Finding Aids

No abstract provided.

The Echo: November 14, 2022, Taylor University

2022-2023 (Volume 110)

No abstract provided.

Fall Prevention Among Older Adult Behavioral Health Patients, Jodie Shipley

Dissertations

Abstract

Problem: Inpatient falls are a major patient safety issue. Behavioral health units experience higher rates of falls among elderly patients with between 13.1 to 25 falls per 1,000 occupied bed days (OBD). The risk of falls for the aged population is increased on a psychiatric unit due to a myriad of issues including psychotropic medications, over-activity on the unit, and confusion (Wong & Pang, 2019).

Methods: This QI project is an observational descriptive pilot intervention evaluation of a redesigned fall prevention program with the aim to reduce falls on a midsized suburban Midwestern inpatient geriatric behavior health …

Should Mindfulness For Health Care Workers Go Virtual? A Mindfulness-Based Intervention Using Virtual Reality And Heart Rate Variability In The Emergency Department., King Pascual, Amiad Fredman, Athanasios Naum, Chaitrali Patil, Neal Sikka

Health Sciences Education Research

BACKGROUND: Research on burnout in the medical community has extensively studied the impact of mindfulness-based interventions (MBIs), which can include meditation, outdoor retreats, in-person didactics, and/or online wellness modules. However, in addition to these MBIs lacking objective, physiological measures for wellness, there has been little to no research involving virtual reality (VR) as an MBI modality for healthcare professionals in the United States.

METHODS: A randomized controlled intervention trial was used to study the impact of VR-based guided-meditations in the form of brief paced-breathing exercises. Heart-rate variability (HRV), a biomarker for relaxation, was measured during each session. Thirty-two participants, consisting …

The Utah Statesman, November 14, 2022, Utah State University

The Utah Statesman

Weekly student newspaper of Utah State University in Logan.

Is There A Role For Allogeneic Hematopoietic Stem Cell Transplantation For Refractory Follicular Lymphoma?, Yang Yang, Xia Bi, Mia Gergis, Usama Gergis

Kimmel Cancer Center Papers, Presentations, and Grand Rounds

No abstract provided.

Uk Supreme Court Rules That English Companies Can Be Sued For Actions Of Foreign Subsidiaries In The Interest Of “Substantial Justice”, Suzanne E. Chiodo

Articles & Book Chapters

No abstract provided.

Resilience And Prenatal Mental Health In Pakistan: A Qualitative Inquiry, Shireen Shehzad, David Arthur, An-Sofie Van Parys, Nicole Letourneau, Gail Wagnild, Shahirose Sadrudin Premji, Nargis Asad, Olivier Degomme

School of Nursing & Midwifery

Background: Women in Pakistan suffer from a high rate of depression. The stress of low-income, illiteracy, exposure to violence and living in a patriarchal society are predisposing vulnerabilities for depression, particularly during and following pregnancy. The resilience of an individual plays a significant role in promoting prenatal mental health, but this has yet to be thoroughly researched. In this article, our objective is to identify the core characteristics of resilience among pregnant women, which will then help us in developing an intervention.
Methods: The exploratory-descriptive study was conducted over 6 months in five different antenatal hospitals in Sindh, Pakistan. A …

Parent Perceptions Of Adolescent Technology Use: Implications For The Parent-Child Relationship, Tiffany Somerville

Dissertations

Technology and social media use are now more popular than ever with adolescents. Problematic technology use has often been associated with decreased mental health and relationship quality. Researchers have typically identified problematic technology use by time spent on a device rather than in an interpersonal context. Phubbing and technoference are two constructs that describe how technology use can potentially be disruptive to in-person interactions. Little research has investigated technology use in the context of the parent-child relationship despite reports from parents that technology use is a frequent source of conflict. Through the theoretical frameworks of Bronfenbrenner’s neo-ecological model and structural …

Escribir El Desarrollo, Desplegar La Cultura: Historias De Imaginación Económica En Colombia Y Brasil, Diego Bustos

Spanish and Portuguese ETDs

In this dissertation, we analyze how a group of artists negotiate through their novels and cultural performances a repertoire of meanings on inequality and plurality, formulating a program of socio-cultural transformation via literature. In the first two chapters, we examine the work by Colombian author Augusto Morales Pino (comprised of four volumes), as proponent of a transnational genealogy of economic development, offering a repertoire of meanings and practices for contemporary public policy in which the concept of middle class predominates. I argue that these representations actively shape the possibility and limits of the contemporary models of inclusion and cultural citizenship. …

The Student Athlete Wellness Portal: Translating Student Athletes’ Prescription Opioid Use Narratives Into A Targeted Public Health Intervention, Anne E. Pezalla, Hyejeong Choi, Francis Mckee, Michelle Miller-Day, Michael L. Hecht

Communication Faculty Articles and Research

Background and Objectives: The opioid epidemic has permeated all strata of society over the last two decades, especially within the adolescent student athletic environment, a group particularly at risk and presenting their own challenges for science and practice. This paper (a) describes the development of a web-based intervention called the Student Athlete Wellness Portal that models effective opioid misuse resistance strategies and (b) details the findings of a single-group design to test its effectiveness. Materials and Methods: Formative research included 35 student athletes residing in the United States, ages 14 to 21, who had been injured in their …

Schools As Community Hubs. Literature Review, Ian Teo, Pru Mitchell, Fabienne Van Der Kleij, Anna Dabrowski

School and system improvement

This literature review focuses on community hub models that include an education setting. The goals of these hubs go beyond improving academic outcomes, and look also to the health and wellbeing of their community. This review explores the ways in which education communities operate as welcoming and enriching places that connect, share, and learn with, not only students, families, and educators, but also their wider community. It focuses on a specific model of school-community partnership, typically known as a school community hub. Core features of community hubs are presented as people, partnerships, place and programs. Benefits and challenges of community …

Digitally Predicting Protein Localization And Manipulating Protein Activity In Fluorescence Images Using 4d Reslicing Gan, Yang Jiao, Lingkun Gu, Yingtao Jiang, Mo Weng, Mei Yang

Electrical & Computer Engineering Faculty Research

While multi-channel fluorescence microscopy is a vital imaging method in biological studies, the number of channels that can be imaged simultaneously is limited by technical and hardware limitations such as emission spectra cross-talk. One solution is using deep neural networks to model the localization relationship between two proteins so that the localization of one protein can be digitally predicted. Furthermore, the input and predicted localization implicitly reflect the modeled relationship. Accordingly, observing the response of the prediction via manipulating input localization could provide an informative way to analyze the modeled relationships between the input and the predicted proteins.