Digital Commons Network^™

Long Read Sequencing And Expression Studies Of Ahdc1 Deletions In Xia-Gibbs Syndrome Reveal A Novel Genetic Regulatory Mechanism, Varuna Chander, Medhat Mahmoud, Jianhong Hu, Zain Dardas, Christopher M Grochowski, Moez Dawood, Michael M Khayat, He Li, Shoudong Li, Shalini Jhangiani, Viktoriya Korchina, Hua Shen, George Weissenberger, Qingchang Meng, Marie-Claude Gingras, Donna M Muzny, Harsha Doddapaneni, Jennifer E Posey, James R Lupski, Aniko Sabo, David R Murdock, Fritz J Sedlazeck, Richard A Gibbs

Faculty, Staff and Students Publications

Xia-Gibbs syndrome (XGS; MIM# 615829) is a rare mendelian disorder characterized by Development Delay (DD), intellectual disability (ID), and hypotonia. Individuals with XGS typically harbor de novo protein-truncating mutations in the AT-Hook DNA binding motif containing 1 (AHDC1) gene, although some missense mutations can also cause XGS. Large de novo heterozygous deletions that encompass the AHDC1 gene have also been ascribed as diagnostic for the disorder, without substantial evidence to support their pathogenicity. We analyzed 19 individuals with large contiguous deletions involving AHDC1, along with other genes. One individual bore the smallest known contiguous AHDC1 deletion (∼350 Kb), encompassing eight …

Natural 2d Layered Mineral Cannizzarite With Anisotropic Optical Responses, Arindam Dasgupta, Xiaodong Yang, Jie Gao

Mechanical and Aerospace Engineering Faculty Research & Creative Works

Cannizzarite is a naturally occurring mineral formed by van der Waals (vdW) stacking of alternating layers of PbS-like and Bi2S3-like two-dimensional (2D) materials. Although the PbS-type and Bi2S3-type 2D material layers are structurally isotropic individually, the forced commensuration between these two types of layers while forming the heterostructure of cannizzarite induces strong structural anisotropy. Here we demonstrate the mechanical exfoliation of natural cannizzarite mineral to obtain thin vdW heterostructures of PbS-type and Bi2S3-type atomic layers. The structural anisotropy induced anisotropic optical properties of thin cannizzarite flakes are explored through angle-resolved polarized Raman scattering, linear dichroism, and polarization-dependent anisotropic third-harmonic generation. …

A New Chapter In An Evolving Pandemic: Successful Pediatric Liver Transplantation With Sars-Cov-2+ Donors, Matthew Benjamin Goss, Daniel Hao Bin Leung, Stephanie Marie Pouch, Flor M Munoz, Elizabeth Andrea Moulton, Tyler Malcolm Mccann Lambing, Sarah Koohmaraie, Nicolas Fernando Moreno, Christine A O'Mahony, John A Goss, Nhu Thao Nguyen Galván

Faculty, Staff and Students Publications

BACKGROUND: Amid a viral pandemic with poorly understood transmissibility and pathogenicity in the pediatric patient, we report the first pediatric liver transplants utilizing allografts from SARS-CoV-2+ donors.

METHODS: We describe the outcomes of two pediatric liver transplant recipients who received organs from SARS-CoV-2 nucleic acid test-positive (NAT+) donors. Data were obtained through the respective electronic medical record system and UNet DonorNet platform.

RESULTS: The first donor was a 3-year-old boy succumbing to head trauma. One of four nasopharyngeal (NP) swabs and 1 of 3 bronchoalveolar lavage (BAL) NAT tests demonstrated SARS-CoV-2 infection before organ procurement. The second donor was a …

Implementing Molecular Tuberculosis Diagnostic Methods In Limited-Resource And High-Burden Countries, Anca Vasiliu, Antonia Morita Iswari Saktiawati, Raquel Duarte, Christoph Lange, Daniela Maria Cirillo

Faculty, Staff and Students Publications

Tuberculosis (TB) is one of the deadliest infectious diseases in the world with more than a million people dying of TB each year. Accurate and timely TB diagnosis has the potential to alleviate the global TB burden; therefore, one of the pillars of the End TB Strategy developed by the World Health Organization (WHO) is the early diagnosis of TB, including universal drug-susceptibility testing (DST). The WHO emphasises the importance of DST before treatment initiation, using molecular WHO-recommended rapid diagnostic tests (mWRDs). Currently available mWRDs are nucleic acid amplification tests, line probe assays, whole genome sequencing, and targeted next-generation sequencing. …

A Narrative Review Of Sex And Gender Differences In Sleep Disordered Breathing: Gaps And Opportunities, Margaret Bublitz, Nour Adra, Leen Hijazi, Fidaa Shaib, Hrayr Attarian, Ghada Bourjeily

Faculty, Staff and Students Publications

Introduction: Sleep disordered breathing (SDB) is a common condition, associated with multiple comorbidities including cardiovascular and metabolic disease. It has been previously established that SDB is more prevalent in men than women, shifting the literature's focus away from the latter population. As such, underdiagnosis, and thus undertreatment, of SDB in women exists.

Methods: To establish the differences in prevalence, clinical presentation, and pathophysiology of SDB between the two sexes, a narrative review of the current literature was performed.

Results: Rates of SDB are higher among men, likely driven by differences in symptom presentation between men and women, with women presenting …

“It’S About The Two Selves”: Experiences In Code-Switching Between Home And Academic Environments, Travis Wolven

Electronic Theses and Dissertations

This qualitative research study is an exploration of how college students navigate code-switching between their home and academic environments. Data were collected from five participants using interview and small group methods. Through the lenses of Coordinated Management of Meaning (CMM) and Memorable Messages (MM) frameworks, the researcher explores how key MMs affect how participants coordinate and manage meaning in communications with others in their home and college environments. Findings were fourfold: 1) participants chose between following established and creating new rules when code-switching; 2) participants shared experiences and strategies regarding knowing when and how to code-switch; 3) preparing audiences for …

Human Islet Amyloid Polypeptide (Hiapp) Protofibril-Specific Antibodies For Detection And Treatment Of Type 2 Diabetes, Angelina S Bortoletto, W Vallen Graham, Gabriella Trout, Alessandra Bonito-Oliva, Manija A Kazmi, Jing Gong, Emily Weyburne, Brandy L Houser, Thomas P Sakmar, Ronald J Parchem

Faculty, Staff and Students Publications

Type 2 diabetes mellitus (T2D) is a major public health concern and is characterized by sustained hyperglycemia due to insulin resistance and destruction of insulin-producing β cells. One pathological hallmark of T2D is the toxic accumulation of human islet amyloid polypeptide (hIAPP) aggregates. Monomeric hIAPP is a hormone normally co-secreted with insulin. However, increased levels of hIAPP in prediabetic and diabetic patients can lead to the formation of hIAPP protofibrils, which are toxic to β cells. Current therapies fail to address hIAPP aggregation and current screening modalities do not detect it. Using a stabilizing capping protein, monoclonal antibodies (mAbs) can …

Statin Use And Risk Of Diabetes By Subclinical Atherosclerosis Burden (From A Multi-Ethnic Study Of Atherosclerosis Report), Mahmoud Al Rifai, Moyses Szklo, Jaideep Patel, Michael J Blaha, Christie M Ballantyne, Vera Bittner, Pamela Morris, John W Mcevoy, Michael D Shapiro, Mouaz H Al-Mallah, Philip Greenland, Salim S Virani

Faculty, Staff and Students Publications

Although there is a significant reduction in atherosclerotic cardiovascular disease risk with statins, a higher risk of diabetes mellitus has been demonstrated in randomized clinical trials. The risk of incident diabetes with statins may be heterogeneous by presence of coronary artery calcium (CAC). We evaluated participants without prevalent diabetes at baseline from the MESA (Multi-Ethnic Study of Atherosclerosis), a prospective cohort study of subjects free of clinical cardiovascular disease at baseline. We used multivariable-adjusted Cox proportional hazards models to study the association between statin use and incident diabetes, adjusting for sociodemographic and cardiovascular risk factors, including time-varying statin use and …

From Computer Curriculum That Works For The Use Of Computer Intellignece Computer Science, Malachi B. Bacchus

Publications and Research

Computer interconnection can link different networks by using electrical artificial flow ways that can travel through different connections. these are called data network which travels through different sectors of the network simulation of service computer network using artificial intelligence to enhanced further understanding the computations, I've also demonstrated knowing by using the network to get better understanding of how ethical computing can be learned through universities and collegiate that can help established knowledge and healthy computer information. The main tools for the research are using data networking, ethical learning and translation towards different computer systems.

Use Of Ai And Machine Learning For Engineering Applications, Max Rios Carballo

Publications and Research

In this paper, we examine how artificial intelligence (AI) and computer-based intelligence (CBI) may be used to address design challenges. We examine artificial intelligence (AI) and machine learning (ML) as they relate to developing applications from the inside out, highlighting the most challenging issues as well as intriguing research areas for further consideration.

Radiomics Of Neurodegeneration In Alzheimer's: Mr, Mrs, & Pet, Analia Basilicata, Jennifer Padilla, Anjalee Rabbani, Anam Riaz

Publications and Research

This work aims to review and assess the current state of Radiology research in Alzheimer’s Disease to complement and coordinate multi-modal research progress via Radiomics. Alzheimer’s Disease. Neuroimaging Initiative (ADNI) is a center that utilizes the different standard methods for the use of clinical magnetic resonance imaging (MRI) and positron emission tomography (PET) and cerebrospinal fluid (CSF) biomarkers for advancing. Early diagnosis and assessing the efficacy of treatment and related biomarkers for Alzheimer's’ Disease. ADNI databases can be assessed to analyze the patterns and changes in imaging and CSF biomarker data with Mild Cognitive Impairment and Alzheimer’s Disease patients. The …

Role Of Bacteriophage Therapy For Resistant Infections In Transplant Recipients, Paul Nicholls, Saima Aslam

Faculty, Staff and Students Publications

Purpose of review: Multidrug-resistant organisms (MDROs) are prevalent in transplant recipients and associated with poor outcomes. We review recent cases of phage therapy used to treat recalcitrant infections in transplant recipients and explore the future role of such therapy in this setting.

Recent findings: Individual case reports and small case series suggest possible efficacy of phage therapy for the treatment of MDRO infections in pre and posttransplant patients. Importantly, there have been no serious safety concerns in the reported cases that we reviewed. There are no applicable randomized controlled trials (RCTs) to better guide phage therapy at this time.

Summary: …

Association Between Cause Of Kidney Failure And Fracture Incidence In A National Us Dialysis Population Cohort Study, Susan Ziolkowski, Sai Liu, Maria E Montez-Rath, Michelle Denburg, Wolfgang C Winkelmayer, Glenn M Chertow, Michelle M O'Shaughnessy

Faculty, Staff and Students Publications

Background: Whether fracture rates, overall and by fracture site, vary by cause of kidney failure in patients receiving dialysis is unknown.

Methods: Using the US Renal Data System, we compared fracture rates across seven causes of kidney failure in patients who started dialysis between 1997 and 2014. We computed unadjusted and multivariable adjusted proportional sub-distribution hazard models, with fracture events (overall, and by site) as the outcome and immunoglobulin A nephropathy as the reference group. Kidney transplantation and death were competing events.

Results: Among 491 496 individuals, with a median follow-up of 2.0 (25%, 75% range 0.9-3.9) years, 62 954 …

Employer Collaboration In Developing Graduate Employability: A Pilot Study In Ireland, Miriam O'Regan, Aiden Carthy, Colm Mcguiness, Philip Owende

Articles

Purpose – The purpose of this paper is to evaluate the impact on student work readiness outcomes of collaboration with employers in developing and delivering tailored graduate employability workshops in socioemotional skills for work (SES4Work).

Design/methodology/approach – Framed by the CareerEDGE model of graduate employability, the authors piloted a five-session module for near graduates in five disciplines. The research included an online employer survey (n 5 128), employer interviews (n 5 21) and tailored workshops for near graduates, culminating in a mock competency-based interview. Using a pre/post-test design, participants (n 5 24) also completed the CareerEDGE Employability Development Profile (EDP) …

The Use Of Najwa Tsurayya Dictionary In Increasing Arabic Vocabulary Memorization For Class Vii Students At Mts Al Irsyad Tengaran 7 Batu City/ استخدام قاموس نجوى الثرايا في زيادة حفظ المفردات العربية لطلبة الصف السابع في المدرسة الثانوية الإرشاد تنجاران, Muhammad Alwan Nursuhaida, Nurul Murtadho

Al-Arabi: Journal of Teaching Arabic as a Foreign Language

This article is the result of research with the aim of describing the implementation of vocabulary learning with Najwa Al-Thoraya's Pocket Dictionary in seventh-grade students of Al-Irshad Tangaran Seventh Secondary School, Batu City. The researcher us

Development Of A Web-Based Crossword Puzzles To Teach Arabic Vocabulary In Islamic Junior High Schools/ تنمية الكلمات المتقاطعة على الإنترنت لتعيلم المفردات في المدرسة الثانوية, M. Adnan Al-Faraid Rahaded, Nurul Murtadho, Mohammad Ahsanuddin

Al-Arabi: Journal of Teaching Arabic as a Foreign Language

The purpose of this research is to design crossword puzzles on the Internet (web) to teach Arabic vocabulary in secondary schools and describe its quality. The researcher used the ADDIE method, which consisted of five stages: analysis, design, developm

Improving The Understanding Of Maharah Qira'ah Students Of Mtsn 3 Jombang Using The Question-Answer Relationships Method, Muhammad Afthon Ulin Nuha, Nurul Musyafa’Ah

Al-Arabi: Journal of Teaching Arabic as a Foreign Language

Seventh-grade students of MTsN 3 Jombang in learning Arabic are still low in understanding questions related to reading. They have difficulty identifying the main ideas in the reading, have not been able to make conclusions, and have problem retelling

Environmental Sensitivity Of Maternal And Offspring Phenotype In The Green Anole (Anolis Carolinensis) Lizard, Jamie Marks

LSU New Orleans Theses and Dissertations

Animals dynamically invest their acquired energetic resources into fitness-related traits, and life-history trade-offs occur when limited resources are invested in a given trait at the expense of another. The phenotypic effects of life history trade-offs are well documented, but the mechanisms facilitating these trade-offs are poorly understood. One such mechanism is the insulin/insulin-like signaling (IIS) network, and specifically its two primary hormones: insulin-like growth factor 1 (IGF1) and insulin-like growth factor 2 (IGF2). IGF1 is well-characterized but IGF2 is severely understudied, though it is present in nearly all amniotes and sometimes expressed at higher levels than IGF1 in adulthood. I …

Teachers’ Perceptions Of Their Roles In Blended Learning Environments, Sabrina E. Pence

LSU New Orleans Theses and Dissertations

Schools are widely implementing blended learning, defined as a combination of face to face instruction and computer-assisted instruction, to increase student achievement. Given that the computer is taking on a component of instruction, there is some evidence that the role of the teacher is changing. The purpose of this study is to understand the perceptions of primary teachers about their role and possible role change in a blended learning environment. A qualitative study using transcendental phenomenology was conducted among a group of primary teachers who teach reading and math in grades K-4. Role theory was applied to illuminate whether the …

A Phenomenological Study Of Principals’ Perceptions Of Instructional Leadership In The Context Of Mandated Teacher Evaluation, Gabrielle P. Delatte

LSU New Orleans Theses and Dissertations

The literature on instructional leadership includes the practices in which principals can engage (Stein & Nelson, 2003) and discusses how the principal’s leadership practices can be mediated by the teacher observation tool within the teacher evaluation system (Spillane, Halverson, & Diamond, 2001). However, the literature includes less about how and why leaders enact those instructional leadership practices (Spillane et al., 2001; Spillane, 2006) and how the teacher evaluation tool might or might not be influencing that how and why. The purpose of this qualitative study is to produce a description of how principals perceive the instructional leadership they provide teachers …

Associations Of The Covid-19 Pandemic With Older Individuals' Healthcare Utilization And Self-Reported Health Status: A Longitudinal Analysis From Singapore, Sangnam Ahn, Seonghoon Kim, Kanghyock Koh

Research Collection School Of Economics

Background: The COVID–19 pandemic has challenged the capacity of healthcare systems around the world and can potentially compromise healthcare utilization and health outcomes among non-COVID–19 patients. Objectives: To examine the associations of the COVID-19 pandemic with healthcare utilization, out-of-pocket medical costs, and perceived health among middle-aged and older individuals in Singapore. Method: Utilizing data collected from a monthly panel survey, a difference-in-differences approach was used to characterize monthly changes of healthcare use and spending and estimate the probability of being diagnosed with a chronic condition and self-reported health status before and during the COVID-19 outbreak in 2020. Subjects: Data were …

Identifying Knowledge Spillovers From Universities: Quasi-Experimental Evidence From Urban China, Li Jing, Shimeng Liu, Yifan Wu

Research Collection School Of Economics

This paper studies the impact of universities on local innovation activity by exploiting a unique university expansion policy in China as a quasi-experiment. We take a geographic approach, empowered by geocoded data on patents and new products at the address level, to identify knowledge spillovers as an important channel. We obtain three main findings. First, university expansion significantly increases universities’ own innovation capacity, which results in a dramatic boom of local industry patents. Second, the impact of university expansion on local innovation activities attenuates sharply within 2 kilometers of the universities. Third, university expansion boosts nearby firms’ new products and …

Global Value Chains And The Cptpp, Pao-Li Chang, Tran Bao Phuong Nguyen

Research Collection School Of Economics

The CPTPP, or the Comprehensive and Progressive Agreement for Trans-Pacific Partnership, is an example of a ‘mega-regional’ free trade agreement, whose provisions on the rules of origin and trade facilitation can potentially have large impacts on CPTPP-wide supply chains. In this paper, we analyse how intensively the CPTPP members participate in the global value chain (GVC), whether they have stronger linkages with members than with non-members, the position of the members in the global and regional network, and whether the CPTPP members are key upstream and downstream trade partners to each other. We develop formulas of GVC position, and importance …

Learning Generalizable Models For Vehicle Routing Problems Via Knowledge Distillation, Jieyi Bi, Yining Ma, Jiahai Wang, Zhiguang Cao, Jinbiao Chen, Yuan Sun, Yeow Meng Chee

Research Collection School Of Computing and Information Systems

Recent neural methods for vehicle routing problems always train and test the deep models on the same instance distribution (i.e., uniform). To tackle the consequent cross-distribution generalization concerns, we bring the knowledge distillation to this field and propose an Adaptive Multi-Distribution Knowledge Distillation (AMDKD) scheme for learning more generalizable deep models. Particularly, our AMDKD leverages various knowledge from multiple teachers trained on exemplar distributions to yield a light-weight yet generalist student model. Meanwhile, we equip AMDKD with an adaptive strategy that allows the student to concentrate on difficult distributions, so as to absorb hard-to-master knowledge more effectively. Extensive experimental results …

Underrepresentation Of Black Males In Gifted Education: A Phenomenology Study Of The Underrepresentation Of Black Males In Gifted Education, James A. Holemon Jr.

Educational Leadership & Workforce Development Theses & Dissertations

The underrepresentation of Black males in gifted education is an issue that all educators acknowledge and understand. What we are less clear on is the influential factors that contribute to the underrepresentation of Black males in gifted education. Therefore, this research will focus on the phenomenology of gifted coordinators and administrators and their subjective experiences as students and educational leaders and how those perceptions and experiences impact systemic educational processes in the identification and selection process of gifted students. A phenomenological approach is utilized to highlight the voices and personal experiences of the practitioners who are on the ground as …

Work Beyond The Work: Amplifying How Black Women Educators Experience Teacher Preparation Programs, Chéleah Victoria Googe

Educational Leadership & Workforce Development Theses & Dissertations

The representation of Black teachers in the field of K-12 education has declined significantly in the last forty years (Ingersoll, 2011; Milner & Howard, 2004). Once considered a pathway to the middle class for Black Americans, teaching was a sought-after profession for Black folks for job stability (Collier, 2002). While there is extensive research on the experiences of teachers of color, and what might lead to their attrition in the teaching profession, Black women experience a specific intersection of race, class, and gender that affects their sustainability in the teaching profession that deserves exploration.

This qualitative research study examined the …

Prepreg Age Monitoring And Qualitative Prediction Of Mechanical Performance Of Composite Using Dielectric State Variables, Monjur Morshed Rabby, Partha Pratim Das, Minhazur Rahman, Vamsi Vadlamudi, Rassel Raihan

SAGE Open Access Agreement Publications-Archive

The aviation and automobile industries have recently depended on thermoset epoxy-based prepreg as a raw material for manufacturing composites. Since prepregs have a limited out-life (i.e., the maximum storing time allowed at room temperature), they must be stored in refrigerators at low temperatures. If not maintained, they can often adversely affect the desired quality of the final product. Prepregs are often discarded once the prepreg out-life ends, leading to a loss of millions of dollars and a detrimental impact on the environment. Therefore, it is necessary to develop a simple method to monitor prepreg aging/degradation in order to ensure its …

Family Writer's Workshop: A Case Study, Alisa Innes

Teaching & Learning Theses & Dissertations

Today’s students need to be prepared for a successful future in our competitive world. Families and educators need to work together to provide children with a comprehensive literacy foundation. Currently, there are many school-based and community-based family literacy programs that are being implemented. While these programs are successful, they are missing a crucial component: writing intervention. Writing is a skill that our students will need for higher education and future careers.

The problem for this study was that research is lacking in regards to ways to assist parents who are interested in working on writing with their child outside of …

Case Study Of A District-University Partnership: Developing Culturally Responsive Educators In A Rural Setting, Trenice Shauntel Durio

Educational Leadership & Workforce Development Theses & Dissertations

Using a theoretical framework of critical race theory and conceptual frameworks of cultural education, this study explores the intersection of district-university partnerships and culturally responsive education. The purpose of this mixed methods case study was to examine the formulation and outcomes of a district-university partnership established to offer a college level course focused on anti-discrimination, equity and inclusion, and social justice in schools. Using survey data, I explored the relationship between participation in the course and the participants’ self-reflection in the areas of empathic concern and perspective taking, preparation for culturally responsive teaching and equitable practices, and comfortability with discussions …

Invisibly Inked: An Intersectional Analysis Of Tattooed Female Arrest Patterns, Jocelyn N. Camacho

Sociology & Criminal Justice Theses & Dissertations

This project fills a gap in the literature of law enforcement response to a visible tattoo on a racialized female arrestee. With the increase in popularity of tattoos and their inherited status as a proxy for deviance, the entanglement of both racialized female bodies and symbols of deviance at the place of entry into the criminal justice system is significant. The racialized female body does not move without carrying the history of violence and inequality on it. As such, the entry of female bodies of Color into the criminal justice system is a time where capturing their experience is critical. …