Digital Commons Network^™

Improving Prediction Accuracy Of Radiation-Induced Temporal Lobe Injury In Nasopharyngeal Carcinoma Using Adc-Based Deep Learning And Dosiomics, Li Wang, Yang Li, Ting Qiu, Junyi Liu, Jiawei Zhou, Han Gao, Hongliang Yu, Yinsu Zhu, Baozhou Sun, Guanyu Yang, Shengfu Huang, Lirong Wu, Li Sun, Xia He

Faculty, Staff and Students Publications

Background: To investigate the potential of apparent diffusion coefficient (ADC) map-based deep learning and dose distribution-based dosiomics in predicting radiation-induced temporal lobe injury (RTLI) in nasopharyngeal carcinoma (NPC).

Methods: This retrospective study included 3578 NPC patients from Jiangsu Cancer Hospital receiving intensity-modulated radiation therapy (IMRT). Ninety-four RTLI patients were recruited based on inclusion criteria and matched 1:1 with 97 control subjects using propensity scores. Patients were randomly assigned to the training cohort (n = 135) and the validation cohort (n = 59). Deep transfer learning (DTL) features and dosiomics features were extracted from ADC map and three-dimensional dose distribution, respectively. …

Defining Clinically Relevant Responses In Erectile Function: An Smsna Position Statement, Landon Trost, Faysal Yafi, Alan Shindel, Mohit Khera, Raymond C Rosen, Petar Bajic, Helen Bernie, Martin Gross, Johanna Hannan, Sevann Helo, Lawrence Jenkins Ii, Carol Podlasek, Daniel Watter, Matthew Ziegelmann, Tobias Köhler

Faculty, Staff and Students Publications

Background: To date, no scoring system has adequately defined clinical efficacy of erectile dysfunction (ED) therapies when evaluating differences between cohorts or in meta-analytic studies.

Aim: To outline the minimal criteria required for any therapy to be considered clinically effective in the treatment of ED.

Methods: An analytic review was performed of standardized ED questionnaires, with a particular emphasis placed on the International Index of Erectile Function, Erectile Function Domain (IIEF-EFD), and the minimally clinically important difference (MCID) concept. The data were used to create a societal position statement and recommendations on best practices within clinical trials to determine treatment …

Overcoming Host Restrictions To Enable Continuous Passaging Of Gii.3 Human Norovirus In Human Intestinal Enteroids, Gurpreet Kaur, Sue E Crawford, Sara Javornik Cregeen, Anil Surathu, B Vijayalakshmi Ayyar, Carmen V Apostol, Hoa Nguyen Phuc, Khalil Ettayebi, Aaya Boussattach, Xi-Lei Zeng, Sarah E Blutt, Harsha Doddapaneni, Donna M Muzny, Cristian Coarfa, Ramakrishnan Anish, B V Venkataram Prasad, Robert L Atmar, Sasirekha Ramani, Mary K Estes

Faculty, Staff and Students Publications

The establishment of human intestinal enteroids (HIEs) as a model for human norovirus (HuNoV) replication has been transformative for studying this leading cause of gastroenteritis. However, indefinite passaging of HuNoVs in HIEs remained a challenge, necessitating the use of patient stool samples as viral inocula. Using RNA-seq, we identified CXCL10, CXCL11, and CCL5 as up-regulated chemokines, suggesting their potential as host restriction factors. TAK-779, a CXCR3/CCR5/CCR2 antagonist, enhanced GII.3 HuNoV replication and viral spread in a dose- and time-dependent manner, enabling successful passaging of GII.3 HuNoV in two different HIE lines and generation of viral stocks. Sequencing passaged virus revealed …

Extracellular Matrix Mediates Circulating Tumor Cell Clustering In Triple-Negative Breast Cancer Metastasis, Georg Om Bobkov, Khushali J Patel, Bree M Lege, Rong Zheng, Gad Shaulsky, Matthew J Ellis, Chonghui Cheng

Faculty, Staff and Students Publications

Metastatic tumor cell dissemination is the leading cause of cancer-related deaths. Clustered circulating tumor cells (CTCs) possess higher metastatic potential than single CTCs. Epithelial adherens junction (AJ) proteins typically mediate stable cell-cell interactions; however, these proteins are frequently lost in highly aggressive triple-negative breast cancers (TNBCs), raising the question of how CTCs from such tumors cluster. Here we show that the extracellular matrix (ECM) component hyaluronan (HA) mediates AJ-independent CTC clustering in TNBCs. HA is necessary and sufficient to drive clustering of tumor cells expressing its receptor CD44. Mechanistically, HA initiates contact between neighboring cells through actin-based membrane protrusions. As …

Identifying Barriers And Facilitators To Audit & Feedback In General Practice In Italy: A Qualitative Study, Anna Acampora, Andriy Melnyk, Emanuele La Gatta, Angelo Nardi, Laura Angelici, Rosemary Frasso, Nera Agabiti

College of Population Health Faculty Papers

BACKGROUND: Audit & Feedback (A&F) interventions are recognized as effective strategies for enhancing healthcare quality, yet they remain relatively underutilized in Italian primary care settings. Recent literature highlights the importance of examining the factors influencing the implementation of these interventions across diverse clinical and organizational settings. Thus, this study aimed to identify such factors by exploring the experiences of professionals involved in an A&F intervention tailored for General Practitioners (GPs) treating chronic illnesses.

METHODS: Using qualitative research methods, this study organized focus groups (FGs) separately for each professional role involved in A&F: GPs, GPs acting as internal group coordinators, Public …

Blindsided, Julia Copeland

Creative Nonfiction Magazine

No abstract provided.

The Brown Study, Richard Rodriguez

Creative Nonfiction Magazine

No abstract provided.

Lessons In Killing For The Black Buddhist Nun, Faith Adiele

Creative Nonfiction Magazine

No abstract provided.

Leaving Babylon, Judyth Har-Even

Creative Nonfiction Magazine

No abstract provided.

Gone In Translation, Kate Small

Creative Nonfiction Magazine

No abstract provided.

Joe Stopped By, Andrei Codrescu

Creative Nonfiction Magazine

No abstract provided.

Going Native, Francine Prose

Creative Nonfiction Magazine

No abstract provided.

The Green Room, Eliot Sloan

Creative Nonfiction Magazine

No abstract provided.

What’S The Story #19, Lee Gutkind

Creative Nonfiction Magazine

No abstract provided.

Between The Lines: Report From A College Classroom: After The Terror, Michael Rosenwald, Rose Toubes

Creative Nonfiction Magazine

No abstract provided.

Adventures In Celestial Navigation, Philip Gerard

Creative Nonfiction Magazine

No abstract provided.

Bridges, Sarah Masey-Warren

Creative Nonfiction Magazine

No abstract provided.

Father, Aine Greaney

Creative Nonfiction Magazine

No abstract provided.

Two Years, Russell Tomlin

Creative Nonfiction Magazine

No abstract provided.

Familiar Things, Samuel F. Pickering

Creative Nonfiction Magazine

No abstract provided.

Second Chances, Melissa Bloch

Creative Nonfiction Magazine

No abstract provided.

Dots On The Page, Susan Messer

Creative Nonfiction Magazine

No abstract provided.

Adventures In Celestial Navigation, Philip Gerard

Creative Nonfiction Magazine

No abstract provided.

Between The Lines: Report From A College Classroom: After The Terror, Michael Rosenwald, Rose Toubes

Creative Nonfiction Magazine

No abstract provided.

Bridges, Sarah Masey-Warren

Creative Nonfiction Magazine

No abstract provided.

Father, Aine Greaney

Creative Nonfiction Magazine

No abstract provided.

Familiar Things, Samuel F. Pickering

Creative Nonfiction Magazine

No abstract provided.

Two Years, Russell Tomlin

Creative Nonfiction Magazine

No abstract provided.

Second Chances, Melissa Bloch

Creative Nonfiction Magazine

No abstract provided.

Dots On The Page, Susan Messer

Creative Nonfiction Magazine

No abstract provided.