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Hampton’S Legacies Across Black And Indigenous Education: Subhumanity, Genocide And Self-Determination Of The Past And Present, Arcasia D. James-Gallaway, M. Nathan Tanner, Francena F.L. Turner Feb 2026

Hampton’S Legacies Across Black And Indigenous Education: Subhumanity, Genocide And Self-Determination Of The Past And Present, Arcasia D. James-Gallaway, M. Nathan Tanner, Francena F.L. Turner

College of Humanities and Social Sciences

How are Black and Indigenous education in the US related? How are antiBlackness and settler colonialism interconnected? This essay addresses these questions, reexamining the history of one of the only US schools to educate both groups: Hampton Normal and Agricultural Institute. To explore the contemporary legacies of Hampton, we bring together a race-centered historical methodology and Black and Indigenous studies perspectives. We argue that three enduring legacies – subhumanity, genocide and self-determination – with roots in the school itself frame the present, collective struggle for Black and Indigenous justice in education. This focus provides both historical and current insights with …


The Perspective Of Rural Secondary Vocational Education Instructors On Employability Skills, Unqualified Advancement, And Expulsion To Reduce Delinquency And Justice System Contact, Stacy Lynn Feb 2026

The Perspective Of Rural Secondary Vocational Education Instructors On Employability Skills, Unqualified Advancement, And Expulsion To Reduce Delinquency And Justice System Contact, Stacy Lynn

Walden Dissertations and Doctoral Studies

In this study, the problem in Tennessee and across the United States where the skills of employability, which are used in the reduction of recidivism, are not being emphasized at the secondary level to prevent delinquency and initial justice system contact was highlighted. The purpose of this study was to explore the perspective of rural secondary vocational educators on student unqualified advancement, expulsion, and program employability skills of students participating in vocational education, referencing the reduction of delinquency and justice system contact. Bandura’s social learning theory and subsequent social cognitive theory were the theoretical frameworks for thematic analysis using interpretative …


Hydroxypropyl Methylcellulose As A Mucoadhesive Polymer In Ethanol-Free Buprenorphine Gel For Neonatal Sublingual Delivery, Sanskruti Dave, Viren Soni, Samarth A. Shah, Walter K. Kraft, Gagan Kaushal Feb 2026

Hydroxypropyl Methylcellulose As A Mucoadhesive Polymer In Ethanol-Free Buprenorphine Gel For Neonatal Sublingual Delivery, Sanskruti Dave, Viren Soni, Samarth A. Shah, Walter K. Kraft, Gagan Kaushal

College of Pharmacy Faculty Papers

Buprenorphine (BUP) is widely used in the treatment of neonatal opioid withdrawal syndrome (NOWS). However, the most compounded formulation contains 30% ethanol, despite regulatory and clinical concerns regarding ethanol exposure in pediatric patients. Thus, this research aimed to develop an ethanol-free sublingual (SL) gel formulation of BUP that would be safe, stable, and suitable for NOWS. Multiple polymers were screened as gelling agents, with hydroxypropyl methylcellulose (HPMC) emerging as the ideal base polymer for the formulation due to its optimal pH, rheological characteristics, and stability. The formulated gels were stored at room temperature and refrigerated conditions for 30 days and …


Emotion Regulation And Stress In Adult Learning Through Social Media Platforms, Jennifer Irocky Feb 2026

Emotion Regulation And Stress In Adult Learning Through Social Media Platforms, Jennifer Irocky

Walden Dissertations and Doctoral Studies

Social media platforms have become significant contexts for informal learning among adults, offering access to information and peer exchange outside of formal educational settings. These platforms are also emotionally complex environments in which stress and emotion regulation may shape learning outcomes. The purpose of this quantitative, nonexperimental study was to examine the relationship between social media use and informal learning in adults, with perceived stress and emotion regulation examined as moderating variables. Secondary data from the Stress in America: The State of Our Nation, 2007–2018 surveys were analyzed, using binary logistic regression with moderation while controlling for age, gender, and …


Ubiquitination-Directed Cytosolic Dna Degradation Governs Cgas-Sting-Mediated Immune Response To Dna Damage, Lei Li, Qi Ye, Jinlu Ma, Zixi Wang, Tianjie Liu, Yuzeshi Lei, Mingming Lu, Jialu Kang, Haohan Xiang, Buyun Li, Shan Xu, Ke Wang, Yule Chen, Jiaqi Chen, Bohan Ma, Wenyue Huang, Mengjiao Cai, Nan Wu, Yanqiang Li, Jiale An, Chongming Jiang, Rui Ye, Jing Liu, Steven H Lin, Yang Gao, Jian Ma, Lei Li Feb 2026

Ubiquitination-Directed Cytosolic Dna Degradation Governs Cgas-Sting-Mediated Immune Response To Dna Damage, Lei Li, Qi Ye, Jinlu Ma, Zixi Wang, Tianjie Liu, Yuzeshi Lei, Mingming Lu, Jialu Kang, Haohan Xiang, Buyun Li, Shan Xu, Ke Wang, Yule Chen, Jiaqi Chen, Bohan Ma, Wenyue Huang, Mengjiao Cai, Nan Wu, Yanqiang Li, Jiale An, Chongming Jiang, Rui Ye, Jing Liu, Steven H Lin, Yang Gao, Jian Ma, Lei Li

Faculty, Staff and Student Publications

Activation of cGAS-STING signaling in cancer cells requires cytosolic DNA produced by intrinsic or treatment-induced DNA damage. However, clinical efforts to exploit this pathway to improve immunotherapy have yielded limited success, highlighting gaps in understanding the link between DNA damage and immunotherapy. Here, we identify ubiquitination-directed cytosolic DNA degradation as a critical determinant for cGAS-STING activation following DNA damage. Mechanistically, the cytosolic DNA exonuclease TREX1 is degraded by the E3 ubiquitin ligase SPOP but is reversely stabilized by the deubiquitinase USP7. Cancer-associated SPOP mutations or USP7 overexpression elevate TREX1 levels, promoting cytosolic DNA degradation and impairing cGAS-STING-mediated immune activation. Notably, …


Multimodal Spatial-Omics Reveal Co-Evolution Of Alveolar Progenitors And Proinflammatory Niches In Progression Of Lung Precursor Lesions, Fuduan Peng, Ansam Sinjab, Yibo Dai, Warapen Treekitkarnmongkol, Sujuan Yang, Lorena I Gomez Bolanos, Tieling Zhou, Minyue Chen, Alejandra G Serrano, Avantika Krishna, Nastaran Karimi, Manvi Sharma, Akshay Basi, Guangsheng Pei, Jianlong Liao, Yunhe Liu, Jiping Feng, Zahraa Rahal, Yang Liu, Jiahui Jiang, Kai Yu, Tala Noun, Yuejiang Liu, Khaja Khan, Kyung Serk Cho, Jichao Chen, Luisa M Solis, Sarah Mazzilli, Steven Dubinett, Tina Cascone, Avrum E Spira, Stephen Swisher, Naoe Jimbo, Takuo Hayashi, Satsuki Kishikawa, Kazuya Takamochi, Tomoo Itoh, Takashi Yao, Kenji Suzuki, Neda Kalhor, Ignacio I Wistuba, Mingyao Li, Seyed Javad Moghaddam, Junya Fujimoto, Jared Burks, Jeffrey Myers, Kadir Akdemir, Linghua Wang, Humam Kadara Feb 2026

Multimodal Spatial-Omics Reveal Co-Evolution Of Alveolar Progenitors And Proinflammatory Niches In Progression Of Lung Precursor Lesions, Fuduan Peng, Ansam Sinjab, Yibo Dai, Warapen Treekitkarnmongkol, Sujuan Yang, Lorena I Gomez Bolanos, Tieling Zhou, Minyue Chen, Alejandra G Serrano, Avantika Krishna, Nastaran Karimi, Manvi Sharma, Akshay Basi, Guangsheng Pei, Jianlong Liao, Yunhe Liu, Jiping Feng, Zahraa Rahal, Yang Liu, Jiahui Jiang, Kai Yu, Tala Noun, Yuejiang Liu, Khaja Khan, Kyung Serk Cho, Jichao Chen, Luisa M Solis, Sarah Mazzilli, Steven Dubinett, Tina Cascone, Avrum E Spira, Stephen Swisher, Naoe Jimbo, Takuo Hayashi, Satsuki Kishikawa, Kazuya Takamochi, Tomoo Itoh, Takashi Yao, Kenji Suzuki, Neda Kalhor, Ignacio I Wistuba, Mingyao Li, Seyed Javad Moghaddam, Junya Fujimoto, Jared Burks, Jeffrey Myers, Kadir Akdemir, Linghua Wang, Humam Kadara

Faculty, Staff and Student Publications

The co-evolution of different cell subsets in the progression of precursor lesions to lung adenocarcinoma (LUAD) is incompletely understood. We generated spatial transcriptomic maps of 56 human precursor lesions and LUADs from 25 patients and of an independent cohort of 36 lesions from 19 patients, analyzing a total of 486,519 spots and 5.4 million cells. We identify region-specific programs that distinguish precursors from LUADs. Spatially resolved clonal architectures reveal patient-specific heterogeneity in evolution of precursors to LUADs. We find epithelial alveolar progenitors expressing tumor-associated meta-programs and residing in niches enriched with proinflammatory subsets including IL1B high macrophages. Epithelial-proinflammatory niches are …


Wdr4 Regulates Ribosome Biogenesis And Intestinal Homeostasis Via Let-7, Kreeti Kajal, Elham Rastegari, Wen-Der Wang, Jian-Chiuan Li, Chun-Hong Chen, Wan Hsuan Chou, Wei Chiao Chang, Tzu-Yang Lin, Kevin Tsai, Tsai Ming Lu, Kartik Venkatachalam, Hwei-Jan Hsu Feb 2026

Wdr4 Regulates Ribosome Biogenesis And Intestinal Homeostasis Via Let-7, Kreeti Kajal, Elham Rastegari, Wen-Der Wang, Jian-Chiuan Li, Chun-Hong Chen, Wan Hsuan Chou, Wei Chiao Chang, Tzu-Yang Lin, Kevin Tsai, Tsai Ming Lu, Kartik Venkatachalam, Hwei-Jan Hsu

Faculty, Staff and Student Publications

Proper regulation of ribosome biogenesis is essential for stem cell function and tissue homeostasis, yet its upstream control in adult intestinal stem cells (ISCs) remains unclear. Here, we identify the WD repeat protein Wdr4 as a key regulator of ISC homeostasis in the Drosophila midgut. Wdr4 cooperates with the methyltransferase Mettl1 to catalyze N⁷-methylguanosine (m⁷G) modification of let-7 miRNA. Wdr4 or Mettl1 depletion disrupts this modification, reducing let-7 levels and aberrantly activating TOR-JNK-dMyc signaling. This drives elevated ribosome biogenesis, ISC overproliferation, misdifferentiation, and intestinal dysplasia. Overexpression of let-7, inhibition of TOR, or suppression of JNK rescues these defects. Importantly, expression …


Prevalence Of Her2-Low Status And Outcomes In Early-Stage Her2-Negative Breast Cancer, Akshara Singareeka Raghavendra, Diane D Liu, Sarah Pasyar, Senthil Damodaran, Yu Shen, Jason A Mouabbi, Carlos H Barcenas, Debu Tripathy Feb 2026

Prevalence Of Her2-Low Status And Outcomes In Early-Stage Her2-Negative Breast Cancer, Akshara Singareeka Raghavendra, Diane D Liu, Sarah Pasyar, Senthil Damodaran, Yu Shen, Jason A Mouabbi, Carlos H Barcenas, Debu Tripathy

Faculty, Staff and Student Publications

HER2-low breast cancer (IHC 1+ or 2+ without HER2 gene amplification) is a distinct and understudied subtype. In a cohort of 14,593 early-stage breast cancer patients treated at MD Anderson from 2006 to 2019, 60.4% were HER2-low. Multivariable analysis showed HER2-low status was independently associated with race, histologic subtype, higher nuclear grade and stage, and estrogen receptor (ER) positivity. Among 2464 patients receiving neoadjuvant chemotherapy, HER2-low status was not linked to pathologic complete response (pCR), overall survival (OS), or disease-free survival (DFS) compared to HER2-0 tumors. Factors predicting pCR included nuclear grade III, stage I, invasive ductal carcinoma, lower ER/PR …


High-Throughput Multi-Organ Proteomics Workflow For Drug Efficacy And Toxicity Analysis, Yun Xiong, Lin Tan, Wai-Kin Chan, Dandan Zhu, Huimin Zhang, Eric S Yin, Sri Ramya Donepudi, Jibin Ding, Bo Wei, Bao Tran, Sara Martinez, Iqbal Mahmud, Faiza Hanif Waghu, Hamish I Stewart, Daniel J Hermanson, Rehan Akbani, John N Weinstein, Junjie Chen, Philip L Lorenzi Feb 2026

High-Throughput Multi-Organ Proteomics Workflow For Drug Efficacy And Toxicity Analysis, Yun Xiong, Lin Tan, Wai-Kin Chan, Dandan Zhu, Huimin Zhang, Eric S Yin, Sri Ramya Donepudi, Jibin Ding, Bo Wei, Bao Tran, Sara Martinez, Iqbal Mahmud, Faiza Hanif Waghu, Hamish I Stewart, Daniel J Hermanson, Rehan Akbani, John N Weinstein, Junjie Chen, Philip L Lorenzi

Faculty, Staff and Student Publications

Rapid and comprehensive analysis of complex proteomes across large sample sets is vital for unlocking the potential of systems biology. We present a high-throughput mass spectrometry (MS) proteomics method that integrates narrow-window data-independent acquisition (nDIA) with short-gradient micro-flow chromatography, enabling profiling of >240 samples per day. This optimized MS approach identifies 6,201 and 7,466 human proteins with 1- and 2-min gradients, respectively. As a practical application, we analyzed 507 samples composed of 13 different tissues from mice treated with the enzyme-drug L-asparaginase (ASNase) or its glutaminase-free Q59L mutant, generating a quantitative profile of 11,472 proteins following drug treatment. The MS …


Artificial Intelligence In Crisis Communication: Investigating Source Effects And Matched Crisis Responses On Stakeholder Perceptions, Erika J. Schneider, Victoria A. Kyriakopoulos, Youngji Seo, Nalae Hong, Moon Lee, Joon Soo Lim Feb 2026

Artificial Intelligence In Crisis Communication: Investigating Source Effects And Matched Crisis Responses On Stakeholder Perceptions, Erika J. Schneider, Victoria A. Kyriakopoulos, Youngji Seo, Nalae Hong, Moon Lee, Joon Soo Lim

Media Studies - All Scholarship

As public relations efforts increasingly integrate AI into operations, examining how the disclosure of AI as the source in organizational crisis communications affects public perceptions is increasingly relevant. This research investigates the effects of AI disclosure across matched crisis responses within a 3 (match crisis response: victim crisis-scapegoating, accidental crisis-excuse, preventable crisis-apology) x 2 (source disclosure: AI vs. human) experimental design survey. Key findings reveal that crisis responses with human sources, compared to those with AI disclosure, led to greater perceptions of organizational reputation and credibility across the three matched crisis responses. AI-disclosed messages from the company were also associated …


The Impact Of Central Bank Digital Currencies News On Bank Stability: Evidence From Asean-5 Countries, Firman Hidayat, Raditya Sukmana, Masrizal Masrizal, Rahmat Heru Setianto Feb 2026

The Impact Of Central Bank Digital Currencies News On Bank Stability: Evidence From Asean-5 Countries, Firman Hidayat, Raditya Sukmana, Masrizal Masrizal, Rahmat Heru Setianto

Bulletin of Monetary Economics and Banking

This study constructs an index reflecting Central Bank Digital Currency (CBDC) news coverage and evaluates its impact on bank stability. The CBDC Attention Index (CBDCAI) is formulated based on more than 533 Reuters Digital News Report articles from 2019 to 2023. Employing the System Generalized Method of Moments (GMM) approach with data from 92 banks across ASEAN-5 nations, and implementing quantile regression for robustness checks, the findings demonstrate a significant relationship between the CBDCAI and bank stability, alongside variables such as bank size and capitalization. These results offer valuable guidance for central banks, especially within the ASEAN-5 region, as they …


Fear From Eating Outside? Assessing The Impact Of Covid-19 Pandemic On Consumer’S Willingness To Utilize Catering Services In China, Yunwei Li, Qiuping Ji, Vivian Valdmanis, Jingqi Li, Guanrou Deng, Rui Guo, Yu Hao, Zhi-Nan Lu Feb 2026

Fear From Eating Outside? Assessing The Impact Of Covid-19 Pandemic On Consumer’S Willingness To Utilize Catering Services In China, Yunwei Li, Qiuping Ji, Vivian Valdmanis, Jingqi Li, Guanrou Deng, Rui Guo, Yu Hao, Zhi-Nan Lu

Bulletin of Monetary Economics and Banking

Since the onset of economic reforms, the catering industry has been playing a crucial role in China’s economic development. However, due to the outbreak of the COVID-19 pandemic, the Chinese government has implemented strict pandemic prevention policies such as (home quarantine and suspending work and production facilities) leading to losses for a variety of industries, especially catering industry. As the main driving force on the demand side, residents’ willingness to pay for catering can play an important role in the post-pandemic economic recovery. In this study, we employ primary data of 1,072 respondents from an online survey to investigate the …


20260209: Dr. Kelli Johnson's Donation, 1952-2025, University Libraries Feb 2026

20260209: Dr. Kelli Johnson's Donation, 1952-2025, University Libraries

Guides to University Archives

These items include materials from University Libraries at Marshall University from 1952-2025. Items were received in 2026 from Dr. Kelli Johnson within the University Libraries and include notable materials about various campus events, such as the MU Textbook Affordability Committee (2022), the Dr. Carter G. Woodson Dinner Honoring Dr. Carla Hayden, Librarian of Congress (2018), Greater Huntington Wall of Fame 2024 Induction Ceremony, June Harless Center 25 Years Celebration (2025), Hooding Ceremony for Grad Students (2025), Marshall vs. Morris Harvey (1952), and WV's Experience in Civil Rights with Eve Faulkes (2024). Please download the finding aid for a full list …


Sustainable Food Systems And Planetary Health Education For Nutritionists And Dietitians:: Prioritising Curriculum Concepts With Q Methodology, Liza Barbour, Sarah Browne, Tracy Everitt, Clare Pettinger, Jessica Wegener, Tina Farokhifar, Sarah Kim, Charlene Tsen, Gary Bonar, Liesel Carlsson Feb 2026

Sustainable Food Systems And Planetary Health Education For Nutritionists And Dietitians:: Prioritising Curriculum Concepts With Q Methodology, Liza Barbour, Sarah Browne, Tracy Everitt, Clare Pettinger, Jessica Wegener, Tina Farokhifar, Sarah Kim, Charlene Tsen, Gary Bonar, Liesel Carlsson

School of Health Professions

Purpose: The global food system is undermining human and planetary health. Urgenttransdisciplinary action is required among food system stakeholders equipped to address complexchallenges. This study identified and prioritised curriculum concepts for tertiary education, with theaim of preparing entry-level nutritionists and dietitians to contribute to sustainable food systems andplanetary health within their practice.Methodology: A mixed-methods Q study was conducted. Curriculum concepts were identified fromliterature and an online survey (n 84, 23 countries), then prioritised by workshop participants (n 43, 11countries) based on relevance for entry-level nutritionists and dietitians. Participants reflected on theirdecision-making process using a post-workshop survey. Data were analysed using …


Lanthorn, Vol. 60, No. 11, February 9, 2026, Grand Valley State University Feb 2026

Lanthorn, Vol. 60, No. 11, February 9, 2026, Grand Valley State University

Volume 60, August 4, 2025 – April 20, 2026

Lanthorn is Grand Valley State's student newspaper, published from 1968 to the present.


Generalization Under Sub-Population Shift: Equitable Models For Imbalanced, Long-Tailed, And Fair Representation Learni, Faizanuddin Ansari Feb 2026

Generalization Under Sub-Population Shift: Equitable Models For Imbalanced, Long-Tailed, And Fair Representation Learni, Faizanuddin Ansari

Doctoral Theses

Machine learning systems often experience performance degradation in real-world scenarios due to subpopulation shift defined as mismatches in the distribution of classes or attributes within datasets. This thesis investigates generalization failures arising from class imbalance, long-tailed distributions, and attribute-level biases (specifically, attribute-level biases that originate from demographic imbalances in sensitive domains, such as medical imaging). It proposes principled strategies to mitigate these effects in both classical and deep learning frameworks. Class imbalance and long-tailed distributions pose significant challenges, especially in real-world applications where minority classes are underrepresented yet critically important. To address these challenges, this work develops novel algorithms and …


Multimodal Spatial-Omics Reveal Co-Evolution Of Alveolar Progenitors And Proinflammatory Niches In Progression Of Lung Precursor Lesions, Fuduan Peng, Ansam Sinjab, Yibo Dai, Warapen Treekitkarnmongkol, Sujuan Yang, Lorena I Gomez Bolanos, Tieling Zhou, Minyue Chen, Alejandra G Serrano, Avantika Krishna, Nastaran Karimi, Manvi Sharma, Akshay Basi, Guangsheng Pei, Jianlong Liao, Yunhe Liu, Jiping Feng, Zahraa Rahal, Yang Liu, Jiahui Jiang, Kai Yu, Tala Noun, Yuejiang Liu, Khaja Khan, Kyung Serk Cho, Jichao Chen, Luisa M Solis, Sarah Mazzilli, Steven Dubinett, Tina Cascone, Avrum E Spira, Stephen Swisher, Naoe Jimbo, Takuo Hayashi, Satsuki Kishikawa, Kazuya Takamochi, Tomoo Itoh, Takashi Yao, Kenji Suzuki, Neda Kalhor, Ignacio I Wistuba, Mingyao Li, Seyed Javad Moghaddam, Junya Fujimoto, Jared Burks, Jeffrey Myers, Kadir Akdemir, Linghua Wang, Humam Kadara Feb 2026

Multimodal Spatial-Omics Reveal Co-Evolution Of Alveolar Progenitors And Proinflammatory Niches In Progression Of Lung Precursor Lesions, Fuduan Peng, Ansam Sinjab, Yibo Dai, Warapen Treekitkarnmongkol, Sujuan Yang, Lorena I Gomez Bolanos, Tieling Zhou, Minyue Chen, Alejandra G Serrano, Avantika Krishna, Nastaran Karimi, Manvi Sharma, Akshay Basi, Guangsheng Pei, Jianlong Liao, Yunhe Liu, Jiping Feng, Zahraa Rahal, Yang Liu, Jiahui Jiang, Kai Yu, Tala Noun, Yuejiang Liu, Khaja Khan, Kyung Serk Cho, Jichao Chen, Luisa M Solis, Sarah Mazzilli, Steven Dubinett, Tina Cascone, Avrum E Spira, Stephen Swisher, Naoe Jimbo, Takuo Hayashi, Satsuki Kishikawa, Kazuya Takamochi, Tomoo Itoh, Takashi Yao, Kenji Suzuki, Neda Kalhor, Ignacio I Wistuba, Mingyao Li, Seyed Javad Moghaddam, Junya Fujimoto, Jared Burks, Jeffrey Myers, Kadir Akdemir, Linghua Wang, Humam Kadara

Faculty, Staff and Student Publications

The co-evolution of different cell subsets in the progression of precursor lesions to lung adenocarcinoma (LUAD) is incompletely understood. We generated spatial transcriptomic maps of 56 human precursor lesions and LUADs from 25 patients and of an independent cohort of 36 lesions from 19 patients, analyzing a total of 486,519 spots and 5.4 million cells. We identify region-specific programs that distinguish precursors from LUADs. Spatially resolved clonal architectures reveal patient-specific heterogeneity in evolution of precursors to LUADs. We find epithelial alveolar progenitors expressing tumor-associated meta-programs and residing in niches enriched with proinflammatory subsets including IL1B high macrophages. Epithelial-proinflammatory niches are …


Research Review: "Black Veterans' Insight On Racial Disparities In Military Administrative Separations", Institute For Veterans And Military Families At Syracuse University Feb 2026

Research Review: "Black Veterans' Insight On Racial Disparities In Military Administrative Separations", Institute For Veterans And Military Families At Syracuse University

Institute for Veterans and Military Families

Military service provides a path toward the middle class by granting veterans benefits, including healthcare and compensation for disabilities acquired during service. Military characterization of service, assigned by the Department of Defense at separation, can qualify or disqualify veterans from benefits access. Black service members are 50% more likely than White service members to receive an Other Than Honorable rather than an Honorable discharge, resulting in disproportionate impediments to the benefits designed to facilitate re-entry into civilian life and prevent poverty. Yet, the Department of Defense provides little meaningful remedy for Black veterans to correct less than Honorable discharges, instead …


Cationic Poly(Glucosamine)-Based Polymers Bind To Glycans With Varying Affinity Facilitating Transport Across The Glycocalyx Of Endothelial Cells, Claire Bridges, Lu Fu, Dan Wang, James D. Sterling, Susanna Liang, Shenda M. Baker, Jonathan Yeow, Megan S. Lord Feb 2026

Cationic Poly(Glucosamine)-Based Polymers Bind To Glycans With Varying Affinity Facilitating Transport Across The Glycocalyx Of Endothelial Cells, Claire Bridges, Lu Fu, Dan Wang, James D. Sterling, Susanna Liang, Shenda M. Baker, Jonathan Yeow, Megan S. Lord

Business and Information Technology Faculty Research & Creative Works

Natural polysaccharides, such as chitosan, offer promising avenues for drug delivery due to their cytocompatibility and ability to interact with cell surfaces. However, the endothelial glycocalyx, a glycan-rich extracellular matrix, presents a barrier that must be navigated for effective intracellular delivery. This study investigates how cationic poly(glucosamine)-based polymers, functionalized with guanidinium or ammonium groups, interact with key glycocalyx components including hyaluronan (HA) and heparan sulfate (HS). We demonstrate that these cationic polymers form tunable biomolecular condensates with glycans, with stronger binding observed for sulfated glycans, HS and heparin, than unsulfated HA. Derivatized chitosan polymers with varied cationic side chains exhibit …


Chimes: February 9, 2026, Calvin University Feb 2026

Chimes: February 9, 2026, Calvin University

Chimes

Turning Point USA opens new chapter at Calvin by Ian Tjoelker

CTC's "Peter and the Starcatcher": Magic, imagination and childhood play by McKenna Wilkinson

Architectural History Exhibition presents Knollcrest architect's market plan by Alec DeYoung & Ella Vanden Berg

SAGA: "Seen, known and loved" by Sarah Sparling

Project Neighborhood coming to an end in 2027 by Evangeline Anga

"Wake Up Dead Man" is an investigation of murder and the church by Maya Oeverman


Familial History Of Aortic Disease Does Not Affect Outcomes Of Fenestrated-Branched Endovascular Aortic Repair In Patients With Complex Aortic Aneurysms, Aidin Baghbani, Safa Savadi, Titia A L Sulzer, Emanuel R Tenorio, Thomas Mesnard, Andrea Vacirca, Bernardo C Mendes, Naveed U Saqib, Steven Maximus, Ying Huang, Gustavo S Oderich Feb 2026

Familial History Of Aortic Disease Does Not Affect Outcomes Of Fenestrated-Branched Endovascular Aortic Repair In Patients With Complex Aortic Aneurysms, Aidin Baghbani, Safa Savadi, Titia A L Sulzer, Emanuel R Tenorio, Thomas Mesnard, Andrea Vacirca, Bernardo C Mendes, Naveed U Saqib, Steven Maximus, Ying Huang, Gustavo S Oderich

Faculty, Staff and Student Publications

Purpose: Familial history of aortic disease has been associated with increased risk of aneurysm-related complications after standard endovascular aortic repair. The aim of this study was to evaluate outcomes of fenestrated-branched endovascular aortic repair (FB-EVAR) for complex aortic aneurysms in patients with or without familial aortic aneurysms (FAAs).

Materials and methods: We reviewed the clinical data of consecutive patients enrolled in a prospective non-randomized study to investigate outcomes after FB-EVAR for treatment of complex aortic aneurysms between 2013 and 2022. Familial aortic aneurysm was defined as occurrence of an aortic aneurysm or dissections in a first- or second-degree relative and …


“U’R-In(E)!- Urine-Albumin-Creatinine Ratio–The Old Kid On A New Block!, Yakubu Bene-Alhasan, Vijay Nambi, Christie Ballantyne Feb 2026

“U’R-In(E)!- Urine-Albumin-Creatinine Ratio–The Old Kid On A New Block!, Yakubu Bene-Alhasan, Vijay Nambi, Christie Ballantyne

Faculty, Staff and Students Publications

No abstract provided.


Consensus Paper: Models Of Cerebellar Functions, Shinji Kakei, Andreea C Bostan, Timothy J Ebner, Mohammad Amin Fakharian, Hiroaki Gomi, Xavier Guell, Marie Hemelt, Huu Hoang, Court Hull, Masato Inoue, Takahiro Ishikawa, Masashi Kameda, Mitsuo Kawato, Shigeru Kitazawa, Mario Manto, Javier F Medina, Hiroshi Mitoma, Keiko Ohmae, Shogo Ohmae, Ken-Ichi Okada, Laurentiu S Popa, Jeremy D Schmahmann, Reza Shadmehr, Peter L Strick, Hirokazu Tanaka, Masaki Tanaka, Tadashi Yamazaki Feb 2026

Consensus Paper: Models Of Cerebellar Functions, Shinji Kakei, Andreea C Bostan, Timothy J Ebner, Mohammad Amin Fakharian, Hiroaki Gomi, Xavier Guell, Marie Hemelt, Huu Hoang, Court Hull, Masato Inoue, Takahiro Ishikawa, Masashi Kameda, Mitsuo Kawato, Shigeru Kitazawa, Mario Manto, Javier F Medina, Hiroshi Mitoma, Keiko Ohmae, Shogo Ohmae, Ken-Ichi Okada, Laurentiu S Popa, Jeremy D Schmahmann, Reza Shadmehr, Peter L Strick, Hirokazu Tanaka, Masaki Tanaka, Tadashi Yamazaki

Faculty, Staff and Students Publications

For a long time, from the nineteenth century to most of the twentieth century, the cerebellum was thought to be an organ that regulates movement. Towards the end of the twentieth century, the brain functions associated with the cerebellum began to extend beyond motor control. Now, there is a consensus that the cerebellum is involved not only in motor functions but also in the most basic autonomic functions and the most complex cognitive and emotional functions, with a focus on predictions and internal models. A new functional model of the cerebellum is needed to explain all layers of brain functions …


Fractionated Radiotherapy Adjuvant To Surgery Of Who-2 Meningioma With And Without Gross Total Resection: A Multicenter, Retrospective Cohort Study Of 1,452 Patients, Christian Mirian, Lasse Rehné Jensen, Adam Gorm Hoffmann, Tareq A Juratli, Andrea Daniela Maier, Pernilla Lindner, Anders Broechner, Sverre H Torp, Helen A Shih, Ramin A Morshed, Jacob S Young, Stephen T Magill, Walter Stummer, Dorothee Cäcilia Spille, Benjamin Brokinkel, Martin Proescholdt, Yasuhiro Kuroi, Konstantinos Gousias, Matthias Simon, Ricardo Prat-Acin, Stéphane Goutagny, Johannes Wach, Erdem Güresir, Junkoh Yamamoto, Young Zoon Kim, Joo Ho Lee, Daniel W Kim, Matthew Koshy, Donald M Cannon, Dennis C Shrieve, Chang-Ok Suh, Jong Hee Chang, Maria Kamenova, Sven Straumann, Jehuda Soleman, Ilker Y Eyüpoglu, Tony Catalan, Austin Lui, Philip V Theodosopoulos, Michael W Mcdermott, Pedro Góes, Fang Wang, Luis Souhami, Marie-Christine Guiot, Tamás Csonka, Toshiki Endo, Tejpal Gupta, Akash J Patel, Tiemo J Klisch, Jun Won Kim, Francesco Maiuri, Valeria Barresi, María Dolores Tabernero, Simon Skyrman, Mechthild Krause, Ian Law, Bjarne Winther Kristensen, Tina Nørgaard Munch, Torstein Meling, Kåre Fugleholm, Paul Blanche, Tiit Mathiesen Feb 2026

Fractionated Radiotherapy Adjuvant To Surgery Of Who-2 Meningioma With And Without Gross Total Resection: A Multicenter, Retrospective Cohort Study Of 1,452 Patients, Christian Mirian, Lasse Rehné Jensen, Adam Gorm Hoffmann, Tareq A Juratli, Andrea Daniela Maier, Pernilla Lindner, Anders Broechner, Sverre H Torp, Helen A Shih, Ramin A Morshed, Jacob S Young, Stephen T Magill, Walter Stummer, Dorothee Cäcilia Spille, Benjamin Brokinkel, Martin Proescholdt, Yasuhiro Kuroi, Konstantinos Gousias, Matthias Simon, Ricardo Prat-Acin, Stéphane Goutagny, Johannes Wach, Erdem Güresir, Junkoh Yamamoto, Young Zoon Kim, Joo Ho Lee, Daniel W Kim, Matthew Koshy, Donald M Cannon, Dennis C Shrieve, Chang-Ok Suh, Jong Hee Chang, Maria Kamenova, Sven Straumann, Jehuda Soleman, Ilker Y Eyüpoglu, Tony Catalan, Austin Lui, Philip V Theodosopoulos, Michael W Mcdermott, Pedro Góes, Fang Wang, Luis Souhami, Marie-Christine Guiot, Tamás Csonka, Toshiki Endo, Tejpal Gupta, Akash J Patel, Tiemo J Klisch, Jun Won Kim, Francesco Maiuri, Valeria Barresi, María Dolores Tabernero, Simon Skyrman, Mechthild Krause, Ian Law, Bjarne Winther Kristensen, Tina Nørgaard Munch, Torstein Meling, Kåre Fugleholm, Paul Blanche, Tiit Mathiesen

Faculty, Staff and Students Publications

Purpose

The role of adjuvant fractionated radiotherapy (aFRT) after gross total resection (GTR) of WHO-2 meningiomas remains unclear. We aimed to estimate the effect of aFRT on recurrence risk and survival following GTR and subtotal resection (STR).

Methods

We analyzed 1452 patients with WHO-2 from our international, multicenter database (followed between 1989 and 2019). Outcomes were recurrence (10-year follow-up) and death (5-year follow-up). Risk estimates were obtained using competing risks and survival analysis. Average treatment effects were estimated by G-computation, adjusted for potential confounding by age, sex, Simpson grade, Ki-67 proliferation index, location, country group (universal healthcare or not), …


Myokine Sirpα Exacerbates Kidney Disease In Diabetes, Jiao Wu, Elisa Russo, Daniela Verzola, Qingtian Li, Helena Zhang, Bhuvaneswari Krishnan, David Sheikh-Hamad, Zhaoyong Hu, William E Mitch, Sandhya S Thomas Feb 2026

Myokine Sirpα Exacerbates Kidney Disease In Diabetes, Jiao Wu, Elisa Russo, Daniela Verzola, Qingtian Li, Helena Zhang, Bhuvaneswari Krishnan, David Sheikh-Hamad, Zhaoyong Hu, William E Mitch, Sandhya S Thomas

Faculty, Staff and Students Publications

Mechanisms responsible for skeletal muscle kidney crosstalk have not been defined. We have determined that a circulating mediator, signal regulatory protein α (SIRPα), impairs intracellular insulin-mediated functions. To elucidate the effect of myokine SIRPα on diabetic kidney disease (DKD), flox mice and muscle-specific (m-specific) SIRPα-KO mice were subjected to an obesity-induced model of diabetes, high-fat diet (HFD; 60%) or insulin-deficient hyperglycemia model, streptozotocin (STZ), and were subsequently exposed to anti-SIRPα monoclonal antibodies. In the obesity-induced diabetic mice, serum SIRPα increased. Genetic deletion of muscle SIRPα protected against obesity and improved intracellular insulin signaling in muscle and adipose tissue, with reduced …


String Project Honors Recital: February 8, 2026, Illinois State University School Of Music Feb 2026

String Project Honors Recital: February 8, 2026, Illinois State University School Of Music

School of Music Programs

This is the ninety-fourth program of the 2025-2026 season.

Kemp Recital Hall

February 8, 2026

1:00 p.m.


Advocate, Spring 2026, Office Of Development And Alumni Affairs, University Of San Diego School Of Law Feb 2026

Advocate, Spring 2026, Office Of Development And Alumni Affairs, University Of San Diego School Of Law

Advocate

No abstract provided.


Discovery And Characterization Of A Novel Pseudomonas Phage Of A New Genus, Paul Nicholls, Justin R Clark, Anthony Maresso Feb 2026

Discovery And Characterization Of A Novel Pseudomonas Phage Of A New Genus, Paul Nicholls, Justin R Clark, Anthony Maresso

Faculty, Staff and Students Publications

Background: Bacteriophages exhibit great diversity and are classically divided into lytic and temperate lifestyles. Commonly, bioinformatics is used to predict the temperate lifestyle. As the nosocomial pathogen Pseudomonas aeruginosa is common in freshwater, this biome represents an ideal location for the discovery of Pseudomonas phages.

Materials and methods: We characterized a genetically distinct species of Pseudomonas phage using next-generation sequencing and conventional microbiological methods. We characterized its lifestyle by purifying infected colonies and identifying persistent phage production.

Results: Genetics revealed a phage of a novel genus. Characterization showed a narrow host range and bioinformatics suggested a lytic lifestyle. Experimental data …


Addressing The Pitfalls Of Misinformation In The Classroom Through Game Based Learning, Taylor S. Strong, Jerome Bingham Feb 2026

Addressing The Pitfalls Of Misinformation In The Classroom Through Game Based Learning, Taylor S. Strong, Jerome Bingham

Georgia International Conference on Information Literacy

As instruction librarians we must strive to strengthen students' literacy when it comes to research. Only a 3rd of American high school students are graduating with the necessary reading and math skills needed for college-level classes. In conjunction with these low reading levels.The current and incoming students are a part of the Gen-Z or Zoomer generation.One of the largest problems Gen Z students face in their daily lives is combating misinformation. The University of Virginia in conjunction with the University of Cambridge conducted a recent study about generations and misinformation. Only 11% of 18 to 29 year olds earned a …


Leveling Up: Introducing High School Students To The College Library, Lisa Nichols, Helen E. Bischoff Feb 2026

Leveling Up: Introducing High School Students To The College Library, Lisa Nichols, Helen E. Bischoff

Georgia International Conference on Information Literacy

For many high school students, visiting a college campus can inspire future aspirations and reduce anxiety by allowing them to visualize themselves as college students. This presentation highlights our experiences as academic librarians collaborating with local high school teachers and librarians to introduce students to the foundations of academic research and critical inquiry while also exposing them to both the college library and the campus environment. Through interactive workshops held on site in the high school library and then on a college campus in an academic library, students had the opportunity to engage with college-level research tools, explore the academic …