Digital Commons Network^™

Risk Stratification Of Low-Dose Cytarabine And Venetoclax In Patients With Aml Ineligible For Intensive Chemotherapy, Andrew H Wei, Panayiotis Panayiotidis, Pau Montesinos, Kamel Laribi, Vladimir Ivanov, Inho Kim, Jan Novak, Rebecca Champion, Walter Fiedler, Maria Pagoni, Julie Bergeron, Stephen B Ting, Jing-Zhou Hou, Takahiro Yamauchi, Jianxiang Wang, Stephen A Strickland, Michael R Savona, Tara L Lin, Anoop Enjeti, Ing Soo Tiong, Sangmin Lee, Gail J Roboz, Relja Popovic, Qi Jiang, Zihuan Liu, Yan Sun, Wellington Mendes, Brenda Chyla, Courtney D Dinardo

Faculty, Staff and Student Publications

Prognostic risk categorization aids treatment selection for patients with acute myeloid leukemia (AML). Although the European LeukemiaNet (ELN) classifications (2017 and 2022) for AML have been used to stratify outcomes for patients receiving intensive chemotherapy, their application to patients receiving less intensive therapy, such as azacitidine plus venetoclax, has been less satisfactory. In response, a 4-gene classifier that stratifies older patients with AML unfit for intensive chemotherapy into those with higher benefit (wild type), intermediate benefit (FLT3-internal tandem duplication [ITD] or NRAS/KRAS mutation), or lower benefit (TP53 mutation) after azacitidine plus venetoclax treatment was developed. We hypothesized that this 4-gene …

Beyond The Cisg: Utilizing Unidroit Principles To Synchronize International Contract Law Beyond Sales Of Goods, Noor Albandar

San Diego International Law Journal

Modern advancements have made it easier than ever for individuals and businesses to enter into cross-border transactions. Contract law in the United States employs legal instruments such as the UCC to aid contracting parties, and international law consists of tools such as the CISG supporting cross-border contracts for the sale of goods. Such tools are important because international transactions for goods occur frequently. This Comment will examine the complexities that arise in the face of international contracts, discuss tools for uniform law that are currently utilized by various governing bodies, and propose further implementation of uniform international contract law. In …

Eepd1 Evolved A Unique Dna Clamping Dimer Protecting Reversed Replication Forks, Runze Shen, Altaf H Sarker, Yue Chen, Min Liu, Sunetra Roy, Andrew S Arvai, Albino Bacolla, Zamal Ahmed, Panagiotis Katsonis, Michal Hammel, Isao Kuraoka, Miaw-Sheue Tsai, Corydon Irie, Lukas Webb, Olivier Lichtarge, Chi-Lin Tsai, Susan E Tsutakawa, Katharina Schlacher, John A Tainer

Faculty, Staff and Student Publications

Exonuclease/endonuclease/phosphatase (EEP)-fold hydrolases are canonically monomeric phosphodiesterases exemplified by APE1, DNase I, and TDP2 nucleases. While EEP family domain containing protein 1 (EEPD1) acts in DNA stress responses, its proposed nuclease activities are enigmatic. Here, we integrate hybrid structural methods, evolution, biochemistry, cancer genomics, plus molecular and cell biology to define EEPD1 structure, assembly, and function at stalled DNA replication forks. Results imply EEPD1 surprisingly requires both unique EEP domain dimer and distinctive tandem Helix-hairpin-Helix [(HhH)2] domains to clamp double-stranded (ds) DNA at reversed DNA replication forks for fork protection. Small-angle X-ray Scattering (SAXS), crystal, and cryo-EM structures unveil an …

Novel Csf Biomarkers For Facilitating Diagnosis Of Cns-Hlh From Other Neuroinflammatory Disorders, Sharat Chandra, Kenneth D Greis, Somchai Chutipongtanate, Nathan Luebbering, Aaron Webster, Kelsey E Poisson, Kristen S Fisher, Kristi Smiley, Rebecca A Marsh, Michael B Jordan, Stella M Davies

Faculty, Staff and Students Publications

Central nervous system (CNS)-hemophagocytic lymphohistiocytosis (HLH) can mimic other neuroinflammatory disorders (ONID), often leading to misdiagnosis. Current diagnostic studies do not reliably distinguish CNS-HLH from ONID. We hypothesized that novel cerebrospinal fluid (CSF) biomarkers identified using unbiased proteomic analysis can facilitate diagnosis of CNS-HLH from ONID. Banked CSF samples were categorized into 3 groups, CNS-HLH, ONID, and controls without CNS inflammation. Proteomic analysis was performed on 25 samples per group (total N = 75). Proteins demonstrating significant changes (>1.5-fold higher and P< .05) in the CNS-HLH compared with ONID and associated with HLH pathophysiology were selected as candidate biomarkers. Cross-platform validation of candidate biomarkers, along with known biomarkers CXCL9 and osteopontin, was performed using enzyme-linked immunosorbent assay (ELISA). One hundred twenty-two proteins were identified on CSF proteomic analysis at 99% confidence. Of these, 10 proteins demonstrated a >1.5-fold change with a P< .05 in CNS-HLH compared with ONID. SerpinG1, lysozyme, and CD14 were selected as candidate biomarkers. ELISA confirmed significant elevation of all 5 biomarkers in CNS-HLH relative to ONID. Median SerpinG1 levels were1242.9 ng/mL in CNS-HLH vs 292.2 ng/mL in ONID (P ≤ .001), lysozyme 222.2 ng/mL vs 65.6 ng/mL (P = .001), and CD14 180.3 ng/mL vs 64.5 ng/mL (P ≤ .001). Median CXCL9 levels were 223.7 ng/mL in CNS-HLH vs 15.5 ng/mL in ONID (P ≤ .001), and osteopontin levels were 356.5 ng/mL vs 92.9 ng/mL (P = .001). These findings demonstrate that novel CSF biomarkers SerpinG1, lysozyme, CD14, and CXCL9 can facilitate diagnosis of CNS-HLH from ONID.

"The Only Place I Feel Understood": A Mixed Methods Survey Of Adolescent And Caregiver Perspectives On Social Media And Parental Controls, Melanie Watt Ramos, Constance M Wiemann, Lauren A Bretz

Faculty, Staff and Students Publications

Purpose

Methods

Results

Synthesis Of Data Products For Ocean Carbonate Chemistry, Li Qing Jiang, Amanda Fay, Jens Daniel Müller, Luke Gregor, Alizée Roobaert, Lydia Keppler, Dustin Carroll, Siv K. Lauvset, Tim Devries, Judith Hauck, Christian Rödenbeck, Nicolas Metzl, Andrea J. Fassbender, Jean Pierre Gattuso, Peter Landschützer, Rik Wanninkhof, Christopher Sabine, Simone R. Alin, Mario Hoppema

Faculty Research, Scholarly, and Creative Activity

As the largest active carbon reservoir on Earth, the ocean is a cornerstone of the global carbon cycle, playing a pivotal role in modulating ocean health and the Earth’s climate system. Understanding these crucial roles requires access to a broad array of data products documenting the changing chemistry of the global ocean as a vast and interconnected system. This review article provides an overview of 68 existing ocean carbonate chemistry data products and data product sets, encompassing compilations of cruise datasets, derived gap-filled data products, model simulations, and compilations thereof. It is intended to help researchers identify and access data …

Celf1 Is A Non-Canonical Eif4e Binding Protein That Promotes Translation Of Epithelial-Mesenchymal Transition Effector Mrnas, Arindam Chaudhury, Natee Kongchan, Shebna A Massey, Rajesh Sharma, Rituraj Pal, Na Zhao, Phoebe Tsoi, Yingmin Zhu, Emuejevoke Olokpa, Sufeng Mao, Sonia Del Rincon, Lucas C Reineke, Richard E Lloyd, Marco Sardiello, Jeffrey M Rosen, Choel Kim, Josephine C Ferreon, Joel R Neilson

Faculty, Staff and Students Publications

Mounting evidence is revealing an increasing complexity of gene regulation at the level of messenger RNA (mRNA) translation. Within mammalian cells, canonical cap-dependent mRNA translation depends on the eIF4F complex, consisting of the m7G mRNA cap-binding protein eukaryotic initiation factor 4E (eIF4E), the helicase eIF4A (eIF4A), and the eIF4G (eIF4G1) scaffolding protein. eIF4G1 additionally binds poly(A) binding protein (PABPC1) to facilitate mRNA circularization and nucleates pre-translation initiation complex assembly to initiate ribosomal scanning. In breast epithelial cells, the CELF1 RNA-binding protein specifically promotes the translation of select epithelial-to-mesenchymal transition (EMT) effector mRNAs by binding GU-rich elements (GREs) within their 3' …

Sikap Indonesia Terhadap Perjanjian Internasional Yang Dibuat Pemerintah Belanda, D. Sidik Suraputra, S.H.

Jurnal Hukum & Pembangunan

Abstract

Relationship Between Vegetation Greenness (Ndvi) And Land Surface Temperature Across Land Cover Types In Ciwidey Sub-Watershed (1990–2020), Syal Syabila, Kuswantoro Marko, Revi Hernina

Jurnal Geografi Lingkungan Tropik (Journal of Geography of Tropical Environments)

Land cover change significantly influences vegetation greenness and land surface temperature (LST), particularly in upstream watershed regions experiencing rapid development. This study aims to analyze changes in vegetation greenness (NDVI), land surface temperature, and their relationship across different land cover types in the Ciwidey Sub-Watershed, Bandung Regency, during 1990–2020. Landsat 5 TM and Landsat 8 OLI images (Path/Row 122/65) acquired in July 1990, 2005, and 2020 were processed using radiometric correction, supervised classification (Maximum Likelihood), NDVI extraction, and mono-window LST algorithm. Land cover classification accuracy was assessed using confusion matrix analysis. Linear regression was applied to evaluate the relationship between …

Reliability And Score Agreement Of A Modified Lower Quarter Y-Balance Test As Compared To The Lower Quarter Y-Balance Test In Healthy Adults, Braden L. Lawson, Jordan Morris, Alan Brubaker Rodriguez, Wendy Wheeler

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

Introduction: The Y-Balance Test (YBT) is a dynamic balance test assessing range of motion, flexibility, neuromuscular control, and strength. The YBT is used to evaluate individuals for increased injury risk, deficiencies, and progress of rehabilitation. Due to the higher cost associated with materials in a YBT kit, a modified YBT (mYBT) was created using three cloth measuring tapes, and three blocks of wood to help mitigate financial barriers. In previous studies the mYBT has demonstrated adequate agreement of composite scores with the Upper Quarter Y-Balance Test (UQYBT). The purpose of this study was to determine the agreement of composite scores …

The Effect Of Vitamin D Supplementation On Serum 25(Oh)D And Its Association With Stress Fractures In High-Risk, Physically Active Adults: A Critically Appraised Topic, Connor Lewis, Martha Yost, Aric J. Warren

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

Clinical Scenario: In collegiate athletic and military populations alike, the repetitive and intense training increase the risk of experiencing a stress fracture, representing a significant time loss and financial cost. Research suggests the use of supplemental vitamin D to prevent the occurrence of stress fractures in high-risk adults. Clinical Question: In high risk, physically active adults, does the effect of vitamin D supplementation on serum 25-hydroxyvitamin D [25(OH)D] concentration effect the occurrence of stress fractures? Clinical Bottom Line: The findings suggest that clinicians should consider the use of supplemental vitamin D as a protective measure against the occurrence of stress …

Nonfiction In First Person, Without Apology, Natalia Rachel Singer

Creative Nonfiction Magazine

No abstract provided.

Conversation With Diane Ackerman, Kathleen Veslany

Creative Nonfiction Magazine

No abstract provided.

“What You Bring Matters”: A Case Study Of Middle School Engineering Teachers’ Pedagogical Content Knowledge, Jessica D. Gale, Dyanne Baptiste Porter, Meltem Alemdar, Sunni H. Newton, Abeera P. Rehmat, Jasmine Choi

Journal of Pre-College Engineering Education Research (J-PEER)

Precollege engineering teachers bring unique backgrounds to their teaching practice. Many follow nontraditional routes to teaching engineering, often coming from teaching other subjects or careers in other fields. Among the many variations influencing engineering teaching practices is pedagogical content knowledge (PCK). This multiple case study explores the PCK of five middle school engineering teachers implementing the same middle school engineering curriculum, STEM innovation and design (STEM-ID). STEM-ID engages students in contextualized challenges that incorporate foundational mathematics and science and advanced manufacturing tools such as computer-aided design and 3D printing while introducing engineering concepts such as pneumatics, aeronautics, and robotics. Drawing …

Numenor, The Mighty And Frail: Proceedings Of The Tolkien Society Seminar 2023 (2025), Ed. By Will Sherwood, Douglas Charles Kane

Journal of Tolkien Research

Book review, by Douglas Charles Kane, of Numenor, The Mighty and Frail: Proceedings of The Tolkien Society Seminar 2023 (2025), ed. by Will Sherwood

Newspaper Illustration

Moberly Family Papers

A newspaper sheet featuring an illustrated story depicting 2 men and a mule. The backside has more written stories and articles.

Everything Is Sound, Kiana Rastrou

Fresh Voices: Composition at Cal Poly

No abstract provided.

Welcome To My Journey, Valeria Salazar

Fresh Voices: Composition at Cal Poly

No abstract provided.

My Most Terrifying Teacher, Emma Pierotti

Fresh Voices: Composition at Cal Poly

No abstract provided.

Rocky Mountain National Park: Local History Miscellaneous Papers 1926 - 1927. Nara Rg 79 Romo Box 13, F M. Johnson, Clarence King, Anna Dickinson, J D. Whitney, W E. Andre, Rufus Sage, Joel Estes, E J. Lamb, Francis Parkman, Roger Toll

Rocky Mountain National Park

Miscellaneous Papers including; Surveying Activities; Letters of James T. Gardiner; The Hayden Survey; writings of Anna Dickenson; J. D. Whitney; W. E. Andree; Rufus Sage; Joel Estes; E. J. Lamb; Francis Parkman; Kit Carson; Dick Rutledge; William Hallett; F. E. Clements; Roger W. Toll; Edmund Rogers; Frank M. Johnson; James Terry Gardiner; Cuthbert Mills; Shep Madera; Jacque Charploot; Clarence Kelsey; Robert Adams; C. C. McCreary; Arch Marvine; Story Ladd; Henry Adams.

Cameron Pass; Medicine Bow Range; North Platte River; Cache la Poudre; South Platte Valley; Charles Christopher Parry; Earl of Dunraven; Windham; Thomas Wyndham Quin;

Rocky Mountain National Park History 1915-1940; 101 Local History File Box 13 (#4), Roger Toll

Rocky Mountain National Park

Miscellaneous Papers including; Surveying Activities; Letters of James T. Gardiner; The Hayden Survey; writings of Anna Dickenson; J. D. Whitney; W. E. Andree; Rufus Sage; Joel Estes; E. J. Lamb; Francis Parkman; Kit Carson; Dick Rutledge; William Hallet

Betty Yelm; Rudy March; Edmund B. Rogers; Verne E. Chatelani; George B. Pratt; Apache; Arapahoe; Comanche Navajo; Osage; Pawnee; J. E. Graf; Dorr G. Yeager; John C. Preston; Louise Bryant; Plainview Lodge; W. A. Bryant; Louise Bryant; Patience Gairns; Owen Wister; Long's Peak; Mount Meeker; Estes Park; Roger Toll; Edward T. Taylor; Rocky Mountain Motorist; Mariana Modena; Lucas Brandt; Mable Shaffer; Josiah …

Miscellaneous Papers On The Early Establishment Of Rocky Mountain National Park: 101 Local History File Box 13 (#2), Anna Dickinson, Roger Toll, Rufus Sage, Joel Estes, Patsey Estes, Abner Sprague, Esther Pickens, Harry Ruffner, Dunham Wrght

Rocky Mountain National Park

Miscellaneous Papers including; Surveying Activities; Letters of James T. Gardiner; The Hayden Survey; writings of Anna Dickenson; J. D. Whitney; W. E. Andree; Rufus Sage; Joel Estes; E. J. Lamb; Francis Parkman; Kit Carson; Dick Rutledge; William Hallet

Miscellaneous Papers Dealing With Rocky Mountain National Park Mineral Rights, Timber Rights And Homestead Exceptions And Extensions. 610 Private Holdings File #1 Box 14, Howard Baker, David Canfield, George F. Ingalls, Stanley Joseph, William E. Robertson, Francis Lanoue, Lawrence C. Merriam, Raymond Mulvany, George Hodson, Carl Swartzlow, Alexander Vogelsang, L C. Way, Albert Bitner

Rocky Mountain National Park

Miscellaneous Papers dealing with Rocky Mountain National Park mineral rights, timber rights and homestead exceptions and extensions.  Howard W. Baker; David H. Canfield; George F. Ingalls; Stanley Joseph; William E. Robertson; Francis D. La Noue;  Lawrence C. Merriam; Raymond O. Mulvany; Geroge Hodson; Carl R. Swartzlow; Alexander Vogelsang; L . G. Way; Albert Bitner; Chester Brodie;

Howard W. Baker; David H. Canfield; George F. Ingalls; Stanley Joseph; William E. Robertson; Francis D. La Noue;  Lawrence C. Merriam; Raymond O. Mulvany; George Hodson; Carl R. Swartzlow; Alexander Vogelsang; L . G. Way; Albert Bitner; Chester Brodie;

Rocky Mountain National Park Local History 1922-1929 File Box 13 #3, Roger Toll, Edmund Rogers, Frank M. Johnson, James Terry Gardiner, Culbert Mills, Shep Madera, Jacque Charploot, Clarence Kelsey, Robert Adams, C C. Mccreary, Arch Marvine, Story Ladd, Henry Adams

Rocky Mountain National Park

Miscellaneous Papers including; Surveying Activities; Letters of James T. Gardiner; The Hayden Survey; writings of Anna Dickenson; J. D. Whitney; W. E. Andree; Rufus Sage; Joel Estes; E. J. Lamb; Francis Parkman; Kit Carson; Dick Rutledge; William Hallett; F. E. Clements; Roger W. Toll; Edmund Rogers; Frank M. Johnson; James Terry Gardiner; Cuthbert Mills; Shep Madera; Jacque Charploot; Clarence Kelsey; Robert Adams; C. C. McCreary; Arch Marvine; Story Ladd; Henry Adams.

Miscellaneous Papers Concerning Purchase Of Privately Owned Lands Within Rocky Mountain National Park; 610 Private Holdings File #3 Box 14, George Miller, Howard Baker, David Canfield, Joseph Taylor, John Mclaughlin, Thomas Allen, James Cooik

Rocky Mountain National Park

Miscellaneous papers concerning purchase of privately owned lands within Rocky Mountain National Park; George Miller; Howard Baker; Hillary Tolson; David Canfield; Joseph Taylor; John McLaughlin; G. A. Moskey; James Cook; F. A. Kittredge; Thomas J. Allen; Donald Kilton; Alice Grange; Eliz Grange; harry Blinn; Ernest Gooch; Alma Gooch; Charles Woods; Freeland Staley; Mable Stopher; Sprague's Hotel; Moraine Lodge; Myrna Evans; Harry Blinn; Edmund Rogers; Charles Chapman; Jack Woods Cottages; J. Preston; Edward Allen; Evelyn Sword; Gertrude Grant; John Griffith; Donald Kilton; Abner Sprague; Eugene Autry; Allen White; William Workman; Edward Doyle; Catherine Walters; Carl Hartzell; George McConley;

Rocky Mountain National Park Lands Acquired By Purchase. 610-01 Purchasing Of Lands File Box 15, Arno Cammerer, F J. Solinsky, Edmond Rogers, John C. Preston, Roger Toll, Stephen Mather, A J. Shepherd, J F. Liebman, Guy Helvering

Rocky Mountain National Park

Miscellaneous letter, memos, list and grinds concerning land purchases between 1923-1935 for Rocky Mountain National Park.   Estes park Development Company; Pieter Hondius; Bradley Patrick; J. D. Stead; J. E. Smith; Autrey Woods; John Griffith; E. O. Gooch; H. E. Blinn; W. A. White; Donald Kilton; J. M. B. Petriken; E. S. Allen; H. K. Allen; F. O. Stanley; Charles Chapman; Alice Grange; C. H. Woods; A. E. Sprague; C. L. reed; W. H. Ashton; Evelyn Sword; William Workman; Redwood Fisher; James Van Duesen; C. B. Duesen; Ethel Curryy; Leonard Pruyn; Thom Skinner; Alex Adams; W. A. Hannus; W. B. Crowther; …

Miscellaneous Papers Dealing With Land Purchases For Rocky Mountain National Park. 610 Private Holdings File #2 Box 14, Lawrence Merriam, David Canfield, Staley Joseph, Francis Lanoue, Howard Baker, Frank Childs, Jerome Miller, John Mclaughlin, George Miller, George Mccaslin, Thomas Welsh, Chester Brodie, Conrad Wirth, Hillory Tolson, John Dower

Rocky Mountain National Park

Miscellaneous Papers discussing appraisals and purchasing of land for Rocky Mountain National Park:  Lawrence Merriam; David Canfield; Staley Joseph; Francis La Noue; Howard Baker; Frank Childs; Jerome Miller; John McLaughlin; George Miller; George McCaslin; Thomas Welsh; Chester Brodie; Conrad Wirth; Hilory Tolson; John Dowerr; Clair Hayden; Frank Gadchanx; T. C. Lee; Henry Rhone; Carolyn Rhone; Crum Cabin; Edward Jackson; William Hall; Myra Lewis; Rocky Mountain Boys Campo; Deer Ridge Chalet; Moraine Park; Beaver Meadow; Brinwood Hotel; Bear Lake Road; Ray Bunnell; Deer Ridge Chalet; Wild Basin; Neil Stanley; Harry Buckingham; Jeanette Cunningham; Wayne Cunningham; Clair Okie Hayden; Frank Gadchaux; Baker …

Miscellaneous Papers And Photos Concerning Homestead Claims Within Rocky Mountain National Park; 610 Private Holdings File #5 Box 14, C R. Trowbridge, Reed Higby, L C. Way, Roger Toll

Rocky Mountain National Park

Miscellaneous Papers and photos concerning homestead claims within Rocky Mountain National Park.     Hewes Kirkwood Quarry; Hewes Kirkwood Ranch; Saint Williams Lodge; F. L. Herron; Charlee Hewes; Alpine Brook; Hewes Kirkwood Inn; Ernest Sjpgren; Longs Peak; Carl Piltz; Almond House; Harry Gulvin;

Miscellaneous Papers Dealing With Land Surveys And Water Rights Within Rocky Mountain Nationoal Park; 614 Land Surveys File Box 15, Van V. Dunn

Rocky Mountain National Park

A discussion of building a road beginning at  the junction of the Estes Park road and Fish Creek.  Estes Park Development Company; Dunraven Ranch; K. J. MacCallum; Burton Sanborn; G. M. Houston; F. O. Stanley; F. J. Burnett; Matthew Auld; Frank Bond; F. J. Solinsky; Grand Lodg3e; Grand Lodge Water System; Harbinson's Ranch

Various Papers And Maps Concerning Assessed Value Of All Privately Owned Property Located In Rocky Mountain National Park. 610 Private Holdings File #2 Box 15, Roger Toll, Robert Sterling Yard, Martha Spears, L C. Way, Clay Tallman

Rocky Mountain National Park

Various Papers and maps concerning assessed value of all privately owned property located in rocky Mountain National Park.  1923 Map of Rocky Mountain National Park; William Hall; Horace Slusser; David Dannells; Mary Dannells; Allen's Park; Julian Johnson; C. S. Burford; Deer Mountain; Harry Nicholls; Grand River; Mary Kirkwood; Fred Bunnell; Henry Lynch; Ray Bunnell; Carl Hartsell; Imogene Greene; Alexander Adams; Lizzie Dickerson; Louise Adams; Robert Southerland; Annie Gregg; James Cairns; Rebeccal McClaren Smith; Andrew Harbison; Mary Harbison; Samuel Stone; James Mitchell; Kate Harbison; Benjamin Mitchell; Ezra Kauffmann; John Hedrick; Isaac Mayfield; Christian Young; Almond House; Mark Christensen; John Rausch; ray …