Digital Commons Network^™

Neutrophil Gelatinase-Associated Lipocalin And Neutrophil-To-Lymphocyte Ratio As Indicators Of Nephropathy In Type 2 Diabetic Mellitus Patients In Ghana: A Case-Control Study, Allwell Adofo Ayirebi, Wina Ivy Ofori Boadu, Stephen Twumasi, Samuel Kwarteng, Benedict Sackey, Lilian Antwi Boateng, Joseph Boachie, Samuel Essien-Baidoo, Daniel Nii Martey Antonio, John Agyemang Sah, Afua Marfowaa, Mayfair Adwapa Mpiani, Joachim Baba Domosie, Abiba Khalifah, Emmanuel Ekow Korsah, Ebenezer Senu, Eugene Arele Ansah, Joseph Yorke, Enoch Odame Anto

Research outputs 2022 to 2026

Introduction: Serum neutrophil gelatinase-associated lipocalin (sNGAL), a renal tubular marker, and neutrophil-to-lymphocyte ratio (NLR), a hematological inflammatory marker are two biomarkers that have recently received attention, because of their association with kidney disease. This study examined the diagnostic value sNGAL and NLR in type 2 diabetes mellitus (T2DM) patients with nephropathy. Materials and Methods: In this hospital-based case-control research, 97 T2DM participants and 70 healthy subjects were included. Participants' information was documented using a structured questionnaire and patient case records. Venous blood was drawn from each participant and early morning midstream urine samples were collected for blood and urine measurements …

Optimizing Agility Training In Team Sport Players—The Role Of Perception-Action Coupling: A Systematic Review With Multi-Level Meta-Analysis, Zhiwei Zhao, Yuhang Liu, Kai Xu

Research outputs 2022 to 2026

Agility, characterized by rapid whole-body movement in response to external stimuli, is a key performance determinant in team sports owing to its reliance on perception-action coupling. Despite its importance, existing evidence on training effects is disproportionately focused on change-of-direction ability, overlooking the perceptual-cognitive demands of true agility. This systematic review therefore sought to quantify the effects of agility-specific training, examine moderators and establish dose-response model in team-sport players, while accounting for perception-action coupling. Following PRISMA 2020 guidelines, systematic searches were conducted in Web of Science, Scopus and PubMed for peer-reviewed English-language studies. Risk of bias was appraised using a modified …

Effect Of A 6-Week Structured Exercise Intervention On Tnf-Α During The Chronic Recovery Phase Of A Burn Injury Compared To Regular Daily Activities: A Pilot Randomised Cross-Over Trial, Tyler Jerome Osborne, Grant Rowe, Dale W. Edgar, Mark Fear, Fiona M. Wood, Timothy Fairchild, Brook Galna, Pippa Kenworthy, Brad Wall

Research outputs 2022 to 2026

Background: Burn injury induces a prolonged inflammatory response that may contribute to long-term metabolic dysfunction. Exercise is known to reduce inflammation in various clinical populations; however, its effect on chronic post-burn inflammation remains unclear. This crossover trial investigated the impact of a 6-week exercise intervention on tumour necrosis factor-alpha (TNF-α) in adults with non-severe burns sustained more than one year prior. Methods: Twenty-one participants were randomised to complete either a 6-week exercise program or a control period first, separated by a 4-week washout. The exercise program comprised three supervised sessions per week of combined resistance and cardiovascular training. Primary (TNF-α) …

Prescribing Tourism: Cultivating Positive Travel Experiences For Individuals With Health Conditions, Fangli Hu, Jun Wen, Sebastian Filep

Research outputs 2022 to 2026

Clinical evidence of tourism's health-related benefits for people with health conditions is notably scarce. Prescribing tourism, wherein medical professionals recommend engaging in tourism activities to enhance overall health and well-being, could offer unique insights into the tourism–health nexus. This paper adopted a conceptual approach, underpinned by a state-of-the-art literature review conducted in accordance with the PRISMA framework to identify knowledge gaps in the existing literature. This paper proposed prescribing tourism as a novel research agenda at the intersection of tourism and health, and further introduced it as a promising approach for people with health conditions, aiming to potentially minimise adverse …

Systemic Functioning Of Puerto Rican Families With A Cancer Patient: A Qualitative-Oriented Mixed-Methods Study, Nicole M. Velez-Agosto

Psychological Science Faculty Publications

Systemic family interventions of Latino families with a cancer patient have been suggested as effective and necessary, but few studies have focused on evaluating systemic functioning to design culturally relevant interventions. The purpose of study was to assess systemic functioning in Puerto Rican families with a cancer patient using the Spanish translated version of the Family Genogram Interview (FGI) that measures Bowen’s four emotional processes in nuclear family and family of origin. Fifty-one Puerto Rican participants related to a cancer patient were interviewed. Results suggested an acceptable reliability for the FGI-Spanish and higher presence of symptoms in a spouse or …

Predictive Validity Of The Obsessive-Compulsive Inventory-4 And Florida Obsessive-Compulsive Inventory-Ii Severity Scale, Eric A. Storch, Ryan J. Mccarty, Maya Zehavi, Mahnoor Ahmad, Joseph D. Hovey, Isabella A. Cruz, Monica E. Ochoa, Nadeen Salhadar, Laura D. Seligman

Psychological Science Faculty Publications

Efficient and accurate screening tools are crucial for improving early identification and treatment outcomes among individuals with obsessive-compulsive disorder (OCD). This study evaluated the sensitivity and specificity of two OCD screening measures: the Obsessive-Compulsive Inventory-4 (OCI-4) and the Florida Obsessive-Compulsive Inventory-II (FOCI-II) severity scale. The measures were administered in a large transnational sample of Spanish speaking Latin American adults (N = 1696) with elevated obsessive-compulsive symptomatology. Participants completed diagnostic interviews (MINI and Y-BOCS) and self-report assessments across 23 sites in 11 countries. Both measures significantly distinguished OCD from non-OCD cases, with the FOCI-II demonstrating somewhat better predictive performance (AUC = …

Systematic, Bibliographic And Statistical Aspects On Multi Generation Recycled Concrete Materials Research: A Review, Henrique Comba Gomes, Maozhou Meng, Katie Jones, William Vevers, Aissa Bouaissi, Boksun Kim

School of Engineering, Computing and Mathematics

This article aimed to review the current literature related to the topic of multiple generation recycled concrete materials considering systematic, bibliographic and statistical aspects. The review was conducted from an adaptation from the systematic review for engineering and experiments (SREE) method. Papers wrote in English with scientific relevance, title and abstract full aligned with the topic were selected from Scopus and Web of Science databases. Bibliographic aspects highlighted the research novelty, the quality of research and prominence for future works. The systematic review aimed to provide insights in the literature concerning multiple recycling concrete materials. Some of the main aspects …

A Multi-Dimensional Analysis Of Household Food Waste In The Republic Of Ireland: Drivers, Patterns, And Impacts, Courage Yaw Krah

Doctoral

Despite growing research on consumer food waste, existing efforts have fallen short of achieving meaningful reductions. This challenge has primarily been attributed to the complex behavioural and demographic diversity within populations, reflected in varying practices of food acquisition, storage, preparation, and disposal. In addition, there is a limited understanding of the broader impacts of discarded food, particularly the environmental, economic, and nutritional losses. This results in an oversimplified view of HFW and leads to less effective intervention strategies. An integrated assessment that incorporates environmental, nutritional, and economic consequences can provide a more holistic representation of the problem and support the …

Thermally Stable Sic Particulate-Reinforced Sic Composites Up To 2000 ℃ Fabricated By Precursor Impregnation And Pyrolysis Method, Jian Gu, Vu Viet Hung, Lun Feng, William G. Fahrenholtz, Daejong Kim, Seyoung Kim, Sea Hoon Lee

Materials Science and Engineering Faculty Research & Creative Works

The thermo-mechanical properties of SiC particulate-reinforced SiC composites (SiC-PRCs), fabricated using precursor impregnation & pyrolysis (PIP) process, were analyzed up to 2000 ℃. The relative density of the SiC-PRCs after 4 PIP cycles was 88.6 %. The number of PIP cycles required decreased to nearly half compared with the conventional PIP method by using ultra-high concentration slurries up to 70 vol%. In addition, room-temperature bending strength (215 MPa) and Young's modulus (269 GPa) improved as the solid loading of the slurry increased. The bending strength increased to 232 MPa at 2000 ℃ in Ar. Despite the thermal deterioration of the …

A Software Package For Generating Robust And Accurate Potentials Using The Moment Tensor Potential Framework, Josiah Roberts, Biswas Rijal, Simon Divilov, Jon Paul Maria, William G. Fahrenholtz, Douglas E. Wolfe, Donald W. Brenner, Stefano Curtarolo, Eva Zurek

Materials Science and Engineering Faculty Research & Creative Works

We present the Plan for Robust and Accurate Potentials (PRAPs), a software package for training and using moment tensor potentials (MTPs) in concert with the Machine Learned Interatomic Potentials (MLIP) software package. PRAPs provides an automated workflow to train MTPs using active learning procedures, and a variety of utilities to ease and improve workflows when utilizing the MLIP software. PRAPs was originally developed in the context of crystal structure prediction, in which one calculates convex hulls and predicts low energy metastable and thermodynamically stable structures, but the potentials PRAPs develops are not limited to such applications. PRAPs produces two potentials, …

Superhard Refractory High-Entropy Diborides, M. D. Hossain, N. S. Mcilwaine, N. O. Marquez-Rios, A. C. Feltrin, V. Chawla, R. A. Mayanovic, W. G. Fahrenholtz, D. Penumadu, E. Zurek, D. W. Brenner, D. E. Wolfe, S. Divilov, H. Eckert, S. Curtarolo

Materials Science and Engineering Faculty Research & Creative Works

Using first-principles calculations and companion experimental validations, we demonstrate that the valence electron concentration (VEC) can be used to self-consistently parameterize the bonding characteristics of high-entropy diborides (HEBs) and in turn predict their mechanical properties. When VEC is 10.0 per formula unit (f.u.), HEBs enter the superhard category where Hv>40GPa because bonding states are optimally filled to resist shear deformation. Conversely, above or below a VEC of 10.0, the hardness decreases due to the filling of antibonding or the emptying of bonding states of the HEBs, respectively. This result is supported by analyses of the electronic structure, bonding, antibonding, …

A Borophosphate Glass Doped With Cobalt Oxide Improves Skeletal Muscle Structure And Function In Myopathic Mice, Jacob A. Kendra, Alexandra G. Naman, Rebekah L. Blatt, Carla D. Zingariello, Richard K. Brow, Steven S. Segal, Aaron B. Morton

Materials Science and Engineering Faculty Research & Creative Works

Skeletal muscle myopathy remains a significant cause of disability with limited treatment strategies. Advancements in tissue engineering have led to the development of borophosphate bioactive glasses (BPBGs) capable of enhancing skeletal muscle structure and function. Using a mouse model of severe myopathy (D2.mdx), we investigated muscle force, regeneration, angiogenesis and inflammation at 14, 70 and 140 days post-treatment (dpt). Tibialis anterior (TA) muscles of D2.mdx mice that received a single injection of cobalt oxide-doped BPBG (CoO-TRIM) particles exhibit greater active force, myofiber size, and regeneration through 70 dpt compared to control D2.mdx mice injected with Saline. Vascular endothelial growth factor …

Microwave Dielectric Properties Of Geopolymer Precursor Powders, Linh T. Duong, Abu Naser Rashid Reza, Kristen M. Donnell, Christopher R. Shearer

Electrical and Computer Engineering Faculty Research & Creative Works

Geopolymers are sustainable structural materials with properties similar to ordinary Portland cement concrete. To better understand the fundamental reaction mechanisms of geopolymers, a microwave materials characterization approach is used. In this research work, the dielectric properties (permittivity and loss factor) of common precursor powders used to make geopolymers (GPPs)—fly ash, lime, metakaolin, silica fume, slag, and zeolite—are measured over the S- and X-band frequency ranges (i.e., 2.0–4.0 GHz and 8.2–12.4 GHz, respectively). The physical characteristics, elemental composition, mineralogical properties, and phase characterization of the GPPs are then correlated to dielectric properties. Permittivity of GPP, classified as pozzolanic or latent hydraulic, …

Interpretable Machine Learning For Personalized Profiling Of Mild Cognitive Impairment From Daily Activities, Budhitama Subagdja, Ah-Hwee Tan, Kenneth Kwok, Iris Rawtaer

Research Collection School Of Computing and Information Systems

Continuous monitoring of individual daily activities is essential to detect mild cognitive impairment (MCI) wherein timely intervention can still be applied to prevent more severe mental decline. Recent approaches in predicting MCI are mostly considering digital biomarkers across individuals but often neglecting specific indicators from a single person over a long period of time. Making this personalized, dynamic, and highly noisy prediction model with irregular distribution of missing information to be explainable and actionable for clinical use, remains a challenge. This paper presents a study on a personalized MCI prediction and profiling from an in-home and mobile cognitive health monitoring …

A Novel Privacy-Preserving User Information Queries Scheme With Functional Policy, Yuhang Lei, Rui Shi, Yang Yang, Chunjie Cao, Huamin Feng

Research Collection School Of Computing and Information Systems

Privacy-preserving information queries enable a requester to obtain only the value f(x) computed over sensitive data x, while preventing disclosure of the underlying records. Existing approaches typically reveal full data, incur high on-chain overhead, or lack fair and verifiable delivery of function outputs. We propose a general-purpose, blockchain-compatible framework that ensures the requester learns only f(x) with no extra leakage and that the provider receives fair payment. The design integrates Adaptor Signatures (AS) for fair exchange and Inner-Product Functional Encryption (IPFE) for fine-grained function extraction. The framework is domain-agnostic and applicable to privacy-sensitive applications such as medical insurance and financial …

Design, Testing, And Safety Performance Of Movable Guardrail Systems: A Prisma-Based Systematic Review, Navid Hashemi Taba, Ahdieh Sadat Khatavakhotan, Majid Tolouei-Rad

Research outputs 2022 to 2026

Movable guardrail systems are increasingly used in work zones, reversible lanes, and temporary traffic operations; however, evidence on their crashworthiness, material performance, and operational reliability remains dispersed across multiple design typologies and regulatory frameworks. This PRISMA-compliant systematic review synthesizes 78 studies involving full-scale crash tests, validated finite-element simulations, field performance evaluations, and compliance evaluations under MASH, EN 1317, NCHRP 350, and AS/NZS 3845.1. The findings indicate that modular rigid barriers reliably achieve TL-3/TL-4 performance when joint alignment and foundation conditions are properly controlled; semi-rigid steel systems provide a practical balance between containment capacity and redeployability, but remain sensitive to post …

Stard-Net: Spatiotemporal Attention For Robust Detection Of Tiny Airborne Objects From Moving Drones, Hasibur Rahman, Sanjay Kumar Madria

Computer Science Faculty Research & Creative Works

The rapid adoption of drones across various domains, alongside advancements in computer vision, has driven growing interest in vision-based airborne object detection from moving aerial platforms. However, this task remains challenging due to the small scale of objects, camouflage within cluttered backgrounds, and occlusions. To address these challenges, we introduce an end-to-end detection framework that integrates a Drone Receptive Field Block (DRFB) to extract multiscale and geometrically diverse features, specifically designed to enhance the detection of small and camouflaged airborne objects. To model motion patterns over time while preserving spatial structure, particularly for detecting camouflaged, cluttered and occluded objects with …

A Survey On Heterogeneous Computing Using Smartnics And Emerging Data Processing Units, Nathan Tibbetts, Sifat Ibtisum, Satish Puri

Computer Science Faculty Research & Creative Works

The emergence of new, off-path smart network cards (SmartNICs), known generally as Data Processing Units (DPU), has opened a wide range of research opportunities. Of particular interest is the use of these and related devices in tandem with their host's CPU, creating a heterogeneous computing system with new properties and strengths to be explored, capable of accelerating a wide variety of workloads. This survey begins by providing the motivation and relevant background information for this new field, including its origins, a few current hardware offerings, major programming languages and frameworks for using them, and associated challenges. We then review and …

Intramolecular Nonbonding Interactions And Geared Phenyl Twisting In Para-Disubstituted 1,4-Diphenylazines: Electron Correlation Effects On Molecular Conformations And Enantiomerization, Kaidi Yang, Harmeet Bhoday, Rainer Glaser

Chemistry Faculty Research & Creative Works

The results are reported of potential energy surface (PES) analyses of six symmetrical azines Y_p − Ph − RC=N − N=CR − Ph − Y_p, namely, the benzaldehyde azines 1H, 2H, and 8H with R = H and the acetophenone azines 1M, 2M, and 8M with R = Me. The Y substituents Cl (1), Br (2), and Me (8) were studied because sets of polymorphs I (C2-symmetry, azine twist τ ≈ 135 ± 10°, disrotatory phenyl twists ϕi ≠ 0°) and II (Ci-symmetry, τ = 180°, conrotatory ϕi ≠ 0°) were crystallized for these three azines. The …

Compensation For Victims Of Crimes: Should Victims’ Financial Means And Insurance Coverage Matter? — Criminal Procedure Code 2010, S 359(1); Public Prosecutor V Ong Eng Siew [2025] Sghc 55, Benjamin Joshua Ong

Research Collection Yong Pung How School Of Law

Under s 359(1) of the Criminal Procedure Code 2010, the court can order an offender to compensate the victim with a sum which the victim would have been able to recover in a civil claim in tort against the offender. The courts have used this useful power extensively, though problems remain. One such problem is seen in Ong Eng Siew, where the court declined to make a compensation order. Given the purpose of the compensation system, the court was not correct to hold – in effect – that the purpose of s 359(1) is to benefit only impecunious victims, and …

Evolutionary Conservation Of Midline Axon Guidance Activity Between Drosophila And Tribolium Frazzled, Piyasi Ghosh, Benjamin C. Wadsworth, Logan Terry, Timothy A. Evans

Biological Sciences Faculty Publications and Presentations

The regulation of midline crossing of axons is of fundamental importance for the proper development of nervous system connectivity in bilaterian animals. A number of conserved axon guidance signaling pathways coordinate to attract or repel axons at the nervous system midline to ensure the proper regulation of midline crossing. The attractive Netrin-Frazzled/DCC (Net-Fra) signaling pathway is widely conserved among bilaterians, but it is not clear whether the mechanisms by which Net and Fra promote midline crossing are also conserved. In Drosophila, Fra can promote midline crossing via Netrin-dependent and Netrin-independent mechanisms, by acting as a canonical midline attractive receptor and …

E3 Ubiquitin Ligases And Asthma Relief, Ajay P. Nayak

Department of Medicine Faculty Papers

No abstract provided.

Ia Et Maintien De L'Ordre : Rapport De Synthèse Des Connaissances Sur La Gouvernance Et L'Utilisation De L'Intelligence Artificielle Par La Police Au Canada, Benjamin Perrin, Geoffrey Liew, Isabelle Sweeney

All Faculty Publications

Les services de police de partout au Canada utilisent, ou explorent, un large éventail de technologies d'intelligence artificielle (IA), y compris la reconnaissance faciale, le maintien de l'ordre prédictif basé sur la localisation, les lecteurs de plaques d'immatriculation automatisés, les rapports de police assistés par IA, la reconnaissance d'objets et l'analyse vidéo, la surveillance des médias sociaux, la détection de coups de feu, le génotypage probabiliste et l'exploration de données.

Bien que promettant des avantages en matière de productivité et de sécurité publique, ces outils soulèvent également diverses préoccupations et risques. Le Canada manque actuellement de mesures législatives et de …

Spatial Profiling Reveals Distinct Molecular And Immune Evolution Of Mouse Lung Adenocarcinoma Precancers With Or Without Carcinogen Exposure, Bo Zhu, Muhammad Aminu, Pingjun Chen, Jian-Rong Li, Chuanpeng Dong, Chenyang Li, Yanhua Tian, Shao-Wei Lu, Hong Chen, Chenxi Ma, Xin Hu, Jie Ye, Andrew Y Liu, Beibei Huang, Frank R Rojas, Parra Cuentas Edwin Roger, Ou Shi, Monique B Nilsson, Alissa Poteete, Khaja B Khan, Wei Lu, Luisa M Solis Soto, Junya Fujimoto, Cara Haymaker, Ignacio I Wistuba, Zhubo Wei, Linghua Wang, Don L Gibbons, Ken Chen, Alexandre Reuben, Jason M Schenkel, John V Heymach, Chao Cheng, Jia Wu, Jianjun Zhang

Faculty, Staff and Student Publications

Tumor evolution involves genetic, transcriptional, and phenotypic alterations that shape cancer cell behavior and interactions with the microenvironment. While single‐cell technologies have advanced our understanding of this process, spatial dynamics remain incompletely characterized. Here, whole‐exome sequencing (WES), imaging mass cytometry (IMC), and spatial transcriptomics (ST) were integrated to study molecular evolution and immune responses in two lung adenocarcinoma (LUAD) mouse models: a genetically engineered model (129S4/Sv‐KrasLSL‐G12D, termed 129S4 K) and a carcinogen‐induced precancer model (129S4 U). Compared to 129S4 K, 129S4 U tumors exhibited higher mutational, neoantigen but lower copy number variation (CNV) burdens at matched developmental timepoints, consistent with …

Non-Synaptic Function And Localization Of Syntaxin-Binding Protein 1 In A Mouse Model Of Stxbp1-Related Epileptic Encephalopathy, Tao Yang, Rajat Banerjee, Yamei Deng, Sheetal Jahagirdar, Joo Hyun Kim, Wu Chen, Mingshan Xue, Alexey I Nesvizhskii, Michael D Uhler, Jack M Parent, Yu Wang

Duncan NRI Faculty and Staff Publications

Objective: De novo mutations in the syntaxin-binding protein 1 (STXBP1), encoded by STXBP1, are among the most prevalent causes of variable neurodevelopmental disorders, including epileptic encephalopathy, developmental delay, and movement disorders. Although STXBP1 has been proposed as a critical presynaptic protein controlling synaptic vesicle exocytosis, clinical phenotypes also suggest that its biological function could be more diverse.

Methods: The expression pattern of STXBP1 was studied using immunostaining in vitro and in vivo. Synaptosome isolation was performed to investigate the synaptic and non-synaptic localization of STXBP1 in the brain. STXBP1 immunoprecipitation followed by mass spectrometry (MS) was conducted to identify protein …

Validation Of Longitudinal Biomarker Screening Algorithms For Hcc Detection In Patients With Cirrhosis, Amit G Singal, Qingchun Jin, Jorge Marrero, Neehar D Parikh, Anna S Lok, Camden Lopez, Stephanie Page-Lester, Lewis R Roberts, Rajender Reddy, Michelle Luster, Saira Khaderi, Sumeet K Asrani, Hashem B El-Serag, Fasiha Kanwal, Ziding Feng, Nabihah Tayob

Faculty, Staff and Students Publications

Background: Blood-based biomarker panels, including GALAD, have been proposed as an alternative to abdominal ultrasound for hepatocellular carcinoma (HCC) surveillance. Studies suggest longitudinal evaluation of biomarkers can improve test performance; however, no large studies have validated these findings.

Methods: We leveraged the HCC Early Detection Strategy (HEDS) study (n=1019 patients with cirrhosis; 99 incident HCC) and Texas HCC Consortium (THCCC) (n=2345 patients with cirrhosis; 126 incident HCC) to compare the performance of fixed-threshold GALAD (cutoff of -1.36), and 4 longitudinal algorithms: longitudinal GALAD, PALAD, mFB-ALAD, and mPEB-ALAD. The HEDS cohort was used to derive longitudinal algorithms, and external validation was …

Beyond Redemption?: Examining The Sixth Circuit’S Dangerousness Approach For As-Applied Challenges To The Felon-In-Possession Ban, Jack Baker

Vanderbilt Law Review

The federal felon-in-possession statute permanently bans felons from possessing firearms, regardless of the severity of the predicate felony conviction. Both a murder conviction and a mail-fraud conviction equally satisfy the statute's elements. Critics thus argue that the statute is too expansive. Despite the criticism, the felon-in-possession ban has generally survived Second Amendment challenges. But the U.S. Supreme Court's decision in New York State Rifle & Pistol Ass'n v. Bruen opened a new angle for constitutional challenges to the felon-in-possession ban. In Bruen, the Supreme Court established a history-and-tradition test for Second Amendment cases. Courts must now find historically analogous gun …

Ai & Policing: Knowledge Synthesis Report On The Governance & Use Of Artificial Intelligence By Police In Canada, Benjamin Perrin, Geoffrey Liew, Isabelle Sweeney

All Faculty Publications

Police services across Canada are using, or exploring, a broad range of artificial intelligence (AI) technologies, including facial recognition, location-based predictive policing, automated licence plate readers, AI-assisted police reports, object recognition and video analytics, social media monitoring, gunshot detection, probabilistic genotyping, and data mining.

While promising productivity and public safety benefits, these tools also raise various concerns and risks. Canada currently lacks AI-specific legislation and regulations governing these new technologies, or even a statement of principles on the governance and use of AI by police.

The Impact Of Bilingual Superintendents On A Multilingual Job Site, Cesar Barajas

Construction Management

Language barriers are frequently encountered on construction job sites. Construction crews can often be limited in their proficiency when speaking English and in states like California, construction superintendents oversee a lot of Spanish-speaking crews. This study aims to identify if bilingual superintendents lead to better performing projects. Communication impacts major metrics of project performance including schedule, rework costs, safety performance, and coordination across trades. This qualitative study includes superintendents, project managers, and field crew semi structured interviews backed by survey answers. Interview participants discuss specific examples of how communication can affect jobsite performance both negatively and positively. Subjects are asked …

The Filamentous Ultrastructure Of The Popz Condensate Is Required For Its Cellular Function, Daniel Scholl, Tumara Boyd, Andrew P Latham, Alexandra Salazar, Asma M A M Khan, Steven Boeynaems, Alex S Holehouse, Gabriel C Lander, Andrej Sali, Donghyun Park, Ashok A Deniz, Keren Lasker

Duncan NRI Faculty and Staff Publications

Biomolecular condensates have key roles in regulating cellular processes. Yet, the relationship between atomic features and condensate function remains poorly understood. We studied this relationship using the polar organizing protein Z (PopZ). Here, we revealed hierarchical assembly of PopZ into a filamentous condensate by integrating cryo-electron tomography, biochemistry, single-molecule techniques and molecular dynamics simulations. The PopZ helical domain drives filamentation and condensation, while the disordered region inhibits them. Phase-dependent conformational changes prevent interfilament contacts in the dilute phase and expose client-binding sites in the dense phase. Perturbing filament formation in vitro alters the dynamics of scaffold and client proteins and …