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The Leadership Lens: A Phenomenological Study Of The Lived Sensemaking Experiences Of School Leaders Implementing Virginia's New Standards Of Accreditation And Accountability, Paul M. Wilson Jr. Apr 2026

The Leadership Lens: A Phenomenological Study Of The Lived Sensemaking Experiences Of School Leaders Implementing Virginia's New Standards Of Accreditation And Accountability, Paul M. Wilson Jr.

Educational Leadership & Workforce Development Theses & Dissertations

This phenomenological study exposes the complex cognitive and organizational processes school leaders navigate as they translate high-stakes state mandates into localized action. By examining the implementation of Virginia’s revised Standards of Accreditation and Accountability (SOA), this study challenges the prevailing managerial paradigm that views policy implementation as a linear, mechanical execution of directives. Instead, grounded in sensemaking theory and SDT, this research conceptualizes implementation as a situated and interpretive act shaped by leaders’ prior experiences, beliefs, and psychological needs for autonomy, competence, and relatedness.

Using a qualitative phenomenological design, data were collected through semi structured interviews with 12 school and …


A Transcendental Phenomenological Study Of The "Intervention Implementation Experience" With Department Chairs And Program Coordinators During A Performance Improvement, Courtney W. Schoolmaster Apr 2026

A Transcendental Phenomenological Study Of The "Intervention Implementation Experience" With Department Chairs And Program Coordinators During A Performance Improvement, Courtney W. Schoolmaster

STEMPS Theses & Dissertations

Minimal research has been conducted on the experiences of department chairs and program coordinators with the implementation of performance improvement in learning outcome assessment. Focusing on a multidisciplinary college that offered associate degrees, technical diplomas, and certificates, located within the SACSCOC region, this transcendental phenomenology aims to understand the lived experiences of department chairs and program coordinators in a community college during the implementation/maintenance phases of a performance improvement initiative for the college’s program and general learning outcome assessment process.

This phenomenological study was conducted with eighteen department chairs and program coordinators, and two semi-structured interviews were conducted via Webex. …


The War Poetry Map Project: Exploring The Physical And Emotional Geography Of Conflict, Colin D. Halloran Apr 2026

The War Poetry Map Project: Exploring The Physical And Emotional Geography Of Conflict, Colin D. Halloran

English Theses & Dissertations

There can be no question that war is shaped by and has shaped cultures, and yet as an object of study it is rarely looked at from a cultural studies perspective. It is the great epics of war that form the cornerstones of Western literary tradition. It is the impact of war that gave rise to fields like trauma and memory studies. It is the propaganda produced, the hijacking of cultural industries, that help perpetuate wars. The War Poetry Map Project and accompanying written dissertation seek to move beyond historical and political contexts and view war as a cultural object. …


The Role Of Autonomy And Motivation On Teacher Retention: A Mixed Methods Study, Jordan Overton Apr 2026

The Role Of Autonomy And Motivation On Teacher Retention: A Mixed Methods Study, Jordan Overton

STEMPS Theses & Dissertations

Teacher retention remains a persistent concern in the United States, with nearly 13% of classrooms unfilled by licensed teachers. Grounded in self-determination theory and basic psychological needs theory, this mixed methods sequential explanatory study examined the relationship between teacher autonomy, motivation, and intentions to leave, while also exploring the contextual factors that shaped teachers’ perceptions of autonomy within their work environments.

In the quantitative phase, survey data were collected from 123 elementary and middle school teachers across three school divisions in Southeastern Virginia. Measures included teacher autonomy, work motivation, and intentions to leave one’s school or division and the teaching …


Electromyography, Prosthetic Properties, And Running Biomechanics In Recreationally Active Persons With Lower Extremity Amputation, Paige M. Agnew Apr 2026

Electromyography, Prosthetic Properties, And Running Biomechanics In Recreationally Active Persons With Lower Extremity Amputation, Paige M. Agnew

Rehabilitation Sciences Theses & Dissertations

Lower extremity loss affects nearly 150,000 individuals in the United States yearly yielding extreme health care costs annually. Typically, prosthetic devices are prescribed for 5-8 years despite known changes to an individual’s gait as time progresses. Patients can expect to undergo approximately 8-12 weeks of gait retraining to improve their comfort and efficiency. Biomechanical changes occur when running with a specific running prosthetic including considerable biomechanical and neuromuscular interlimb asymmetries and alterations in loading patterns. The purpose of this dissertation was to investigate the biomechanical demands for lower extremity prosthesis users during running. The first study synthesized peer reviewed evidence …


Cultural Memory And Colonial Legacies: The Pandemic Era In France, Kathryn (Kate) R. Cross Apr 2026

Cultural Memory And Colonial Legacies: The Pandemic Era In France, Kathryn (Kate) R. Cross

Graduate Program in International Studies Theses & Dissertations

In the twenty-first century, how are former colonial powers addressing colonial legacies? Amidst the massive social movements of the pandemic years and greater representations of a new generation of politicians in major elections, the global zeitgeist was increasingly characterized by representation of disenfranchised and previously silenced memories and narratives. These shifts, especially in France, are a sharp contrast to the unofficial historic policy of amnesia maintained regarding traumatic legacies and build on movements that began at the turn of the century. The environment has facilitated an increased ability for cultural products to create, shape, and sustain cultural memories of colonial …


Bioengineering The Future Of The Human Species: H+’S Ideological Iterations Of Trans-/Posthumanity As Exemplified By Futurist Literary Texts = (Bio)Technological Solutions For (And/Or) Reification Of Systemic Inequities?, Marjorie E. Bomhower Apr 2026

Bioengineering The Future Of The Human Species: H+’S Ideological Iterations Of Trans-/Posthumanity As Exemplified By Futurist Literary Texts = (Bio)Technological Solutions For (And/Or) Reification Of Systemic Inequities?, Marjorie E. Bomhower

English Theses & Dissertations

While humanity has, throughout our species’ history, endeavored to dream and create astonishing, and ever-evolving, (bio)technologies with the utopian ideals of bettering our day-to day lives and achieving greater longevity, our endeavors have (thus far) not only produced remarkable, beneficial advances in longevity and quality of life, but have also yielded devastating and dire outcomes; often at the cost and victimization of marginalized communities. This dissertation focuses on select (bio)technologies – particularly, those promoted by H+ (the most current and popular technoutopianist non-profit, “educational,” organization) – with an investigation of current and nascent (bio)technological evolutions, futurist literary texts, and critical/digital …


Axillary Management After Neoadjuvant Endocrine Therapy (Net), Laura Leonard, Min Yi, Emma Wingate, Puneet Singh, Abigail Caudle, Rosa F Hwang, Isabelle Bedrosian, Vicente Valero, Jennifer Litton, Nuhad Ibrahim, Kelly K Hunt Apr 2026

Axillary Management After Neoadjuvant Endocrine Therapy (Net), Laura Leonard, Min Yi, Emma Wingate, Puneet Singh, Abigail Caudle, Rosa F Hwang, Isabelle Bedrosian, Vicente Valero, Jennifer Litton, Nuhad Ibrahim, Kelly K Hunt

Faculty, Staff and Student Publications

BACKGROUND: In patients with hormone receptor-positive (HR

PATIENTS AND METHODS: We performed a retrospective review of patients with clinical stage I-III, HR

RESULTS: A total of 230 patients were included; 120 (52.2%) were clinically node-negative (cN0), while 110 (47.8%) were clinically node-positive (cN+). In the cN+ group, 7.3% (8/110) had a nodal pathologic complete response (pCR). In total, 76.4% (84/110) in the cN+ group underwent axillary lymph node dissection (ALND) as the initial axillary procedure, and 90.9% (100/110) underwent ALND overall. In total, 98.3% (118/120) with cN0 disease underwent sentinel lymph node dissection (SLND), and 28 (23.7%) had positive nodes. …


The Impact Of Multimedia Glossing In Vocabulary Retention In Farsi Learning: Challenges And Opportunities, Farideh Langari Ferdowsi Apr 2026

The Impact Of Multimedia Glossing In Vocabulary Retention In Farsi Learning: Challenges And Opportunities, Farideh Langari Ferdowsi

Doctoral Dissertations

Vocabulary acquisition is key to developing foreign language skills, but students, especially those learning less commonly taught languages, often struggle with new words’ retention. Multimedia glossing, which combines text, audio, and visuals, aims to help students manage cognitive load and learn vocabulary more effectively. While most research has focused on student perspectives, little is known about Farsi language teachers’ views on multimedia glossing and its challenges. This qualitative study explores Farsi teachers’ opinions on using multimedia glossing to support vocabulary learning and retention, as well as the obstacles they face.

This study took place at a Bay Area language school …


Women's Displacement And The Reclamation Of Identity: Navigating Landscapes Of Contestation In The Postcolonial Novel, Carol P. Harvest Apr 2026

Women's Displacement And The Reclamation Of Identity: Navigating Landscapes Of Contestation In The Postcolonial Novel, Carol P. Harvest

English Theses & Dissertations

Landscapes affected by colonial domination are contested landscapes—places not only in danger of environmental destruction through colonial and neocolonial violence but also landscapes of struggle for people who survive in these precarious spaces. Historically, separate postcolonial and ecocritical literary analysis addressed contested landscapes; postcolonial critique centered on the lasting devastation of colonial violence on people and place, while ecocriticism, in its infancy, enjoyed the privilege of ignorance, focusing on endangered species and the preservation of land, but it did not consider the impact of landscapes on the very people who were largely forced to either leave or cross “natural” spaces. …


Does Short-Termism Pay? National Short-Termism, Investment, Innovation, And Equity Returns, Andrew H. Cohen Apr 2026

Does Short-Termism Pay? National Short-Termism, Investment, Innovation, And Equity Returns, Andrew H. Cohen

Theses and Dissertations in Business Administration

We examine whether national short-termism, inferred from corporate language, predicts future real activity, equity returns, risk, and risk-adjusted performance. Using large-scale textual analysis of issuer-linked disclosures and earnings transcripts from the largest firms in twenty major equity markets, we construct country-quarter and annual Short-Termism Scores (STS) capturing the relative emphasis on short- versus long-horizon language.

Higher short-termism predicts lower subsequent gross fixed capital formation, lower research and development intensity, and lower multi-year equity index returns across horizons of up to sixteen quarters. In addition, higher short-termism is associated with greater future market volatility and lower Sharpe ratios, indicating a deterioration …


Personality Predictors Of Cybersecurity Vulnerability: Insights From Self-Reports And Stimulated Threat Scenarios, Saroja Roy Grandhi Apr 2026

Personality Predictors Of Cybersecurity Vulnerability: Insights From Self-Reports And Stimulated Threat Scenarios, Saroja Roy Grandhi

Psychology Theses & Dissertations

In this cyber dependent and enabled era, understanding the role of human factors in digital security is essential. This study investigates the relationship between Big-Five personality traits and cybersecurity behaviors by examining both self-reported and stimulated behaviors in security threat scenarios. Participants completed validated questionnaires to report their personality traits, cybersecurity practices and engage in task-based stimulations to capture behaviors such as phishing detection, password creation, and response to security alerts. The study tested whether higher conscientiousness, openness, and agreeableness would be associated with stronger cybersecurity practices and smaller discrepancies between self-reported and observed behaviors. And, whether greater extraversion and …


Effects Of Cross-Language Instructional Design On Foreign Language Learners' Cognitive Load: Approaching The Redundancy Principle Of Multimedia Learning, Leonor Mendiola Adams Apr 2026

Effects Of Cross-Language Instructional Design On Foreign Language Learners' Cognitive Load: Approaching The Redundancy Principle Of Multimedia Learning, Leonor Mendiola Adams

STEMPS Theses & Dissertations

Because conceptualizations of cognitive resources play a critical role in determining the effectiveness of instructional design (Greeno, 2011; Greeno et al., 1996; Mayer, 2011, 2019), this study explores the effects of cross-language instructional design on learners’ perceived intrinsic, extraneous, and germane cognitive load content corresponding to content complexity, instructional presentation demands, and depth of understanding and schema construction, respectively.

Grounded in the redundancy principle of the Cognitive Theory of Multimedia Learning, this research further investigates whether the principle operates differently when learners’ native language is strategically incorporated into foreign language learning contexts. According to the cognitive theory of multimedia learning, …


“Recollecting The Told Story”: Storytelling, Activism, And The Black Maternal Health Emergency, Lamaya C. Williams Apr 2026

“Recollecting The Told Story”: Storytelling, Activism, And The Black Maternal Health Emergency, Lamaya C. Williams

English Theses & Dissertations

Storytelling is a foundational component of Black knowledge creation and transmission. This dissertation centers Black women’s stories of birth and mothering—drawing on both primary source birth stories and fictional narratives—to examine the United States’ Black Maternal Health Emergency (BMHE). The BMHE is a complex and urgent issue wherein structural racism, medical bias, and intersecting social determinants disproportionately endanger the health of Black mothers. As such, Black mothers in the United States are three times more likely to die from a pregnancy-related condition compared to their white counterparts.

This study examines the birth stories of women who survived the BMHE and …


Back Yard Lingo: Language As Cultural Identity In American Circus, Aíne Norris Apr 2026

Back Yard Lingo: Language As Cultural Identity In American Circus, Aíne Norris

English Theses & Dissertations

This project is an exploration of the deeply insider language of American circus and identifies meaningful patterns and connections between language, identity, and community. Drawing upon the theoretical lenses of cultural studies and community of practice, the study offers a thorough examination of how circus people use insider language for business, performance, and community purposes that enhance belonging, share knowledge, gatekeep, and protect their group identity.

The research employs a mixed-methods, scaffolded design that integrates both qualitative and quantitative data approaches, examining the cultural importance of circus language as written and spoken by the insider community. The design begins with …


Eagle-Winged Worms: Seeing Contingent Faculty Through Currere, Nicholas Hayes Apr 2026

Eagle-Winged Worms: Seeing Contingent Faculty Through Currere, Nicholas Hayes

Theses and Dissertations from DePaul University

This currere explores my experiences as part-time contingent faculty working at multiple institutions (a so-called freeway flyer). Covering the years from 2005-2015, the regressive mode draws from my experiences teaching writing composition and literature at a community college, arts college, and three religious universities. A central impetus for this exploration is a desire to understand the ways I was socialized by these institutions and how that socialization shaped my understanding of my identity within and through my status as contingent faculty. Higher education (especially first-year writing programs) has become dependent on contingent faculty. The increased reliance on part-time contingent faculty …


The Role Communication, Collaboration, And Leadership Practices Play In Parents’ High School Volunteering Experiences: An Exploratory Qualitative Case Study, Julee Gould Apr 2026

The Role Communication, Collaboration, And Leadership Practices Play In Parents’ High School Volunteering Experiences: An Exploratory Qualitative Case Study, Julee Gould

Theses and Dissertations from DePaul University

This qualitative case study explored parents’ perceptions and experiences related to volunteering at a suburban high school in California, with a focus on both the motivations and challenges that shape involvement. Guided by two central research questions, the study explored (1) parents’ perceptions regarding the motivations and challenges for parent volunteering at the high school and (2) how parents feel about their experiences when volunteering as their children transition from elementary to secondary school. While existing research consistently links parent involvement to improved academic and emotional outcomes for students, parental engagement often declines during the secondary years. By integrating an …


Surviving The Hood: An Autoethnography On Violence, Trauma, And Agency, Deonte Tanner Apr 2026

Surviving The Hood: An Autoethnography On Violence, Trauma, And Agency, Deonte Tanner

Theses and Dissertations from DePaul University

The epidemic of gun violence is no secret in the United States. Many empirical studies have focused on gun violence, trauma, and race, and have even offered solutions to the phenomenon. However, limited research has called forward the voice of those most impacted (Black boys) and the counters they believe are feasible to their own experience. This work was grounded in critical race theory (CRT). At the same time, it attempted to supplement CRT with careful reflection on what helped me avoid the very kinds of historical and structural exclusions facing Black boys in the hood that CRT helps reveal. …


Antecedents Of The Principal Investigator’S Commercial Success When Funded By Small Business Innovation Research Program, Mohammed Bekkour Apr 2026

Antecedents Of The Principal Investigator’S Commercial Success When Funded By Small Business Innovation Research Program, Mohammed Bekkour

Theses and Dissertations from DePaul University

The commercial performance of Small Business Innovation Research (SBIR) projects remains substantially below national expectations despite decades of investment and strong technical output. Prior research suggests that commercialization outcomes depend not only on technological merit but also on the behavioral, cognitive, and managerial competencies of the Principal Investigator (PI), who often serves as both scientific lead and entrepreneurial decision-maker. Yet, systematic examination of PI-level attributes within SBIR contexts remains limited. This study investigates how six key constructs—Iterative Learning Process, Proactiveness, Organizational Risk Orientation, Scope Definition, Management Competence, and Simultaneous Project Engagement—relate to commercialization success among SBIR Phase II awardees. Drawing …


Beyond The Script: A Qualitative Study Exploring Drama Teachers’ Experiences Using Improvisation In Chicago Public Schools, Nicole Theresa Minardi Apr 2026

Beyond The Script: A Qualitative Study Exploring Drama Teachers’ Experiences Using Improvisation In Chicago Public Schools, Nicole Theresa Minardi

Theses and Dissertations from DePaul University

Scripted and standardized curricula remain prevalent in American classrooms. Relying on an authoritarian view of education, in which the teacher imparts knowledge to students, scripted curricula can delegitimize the teaching profession, stifle dialogue, and limit student engagement. Conversely, decentering the teacher can create space for more collaborative and engaged learning. This basic interpretive qualitative study explored how Chicago Public Schools drama teachers described their experiences incorporating improvisation into their instruction. Grounded in critical pedagogy and a social constructivist epistemology, this study examined how drama teachers currently use improvisation in their classrooms, as well as the benefits and challenges they encounter …


Does One Size Fit All? A Lifespan Perspective On The Relationship Between Work Design And Mental Health, Christina Ju Apr 2026

Does One Size Fit All? A Lifespan Perspective On The Relationship Between Work Design And Mental Health, Christina Ju

Theses and Dissertations from DePaul University

As the global workforce ages, traditional work design models that assume job resources are universally beneficial require re-evaluation. Drawing upon lifespan development and socioemotional selectivity theory, this longitudinal study examined how chronological age moderates the effects of skill discretion and coworker support on job-related mental health over a 20-year period. Data from three waves of the Midlife in the United States (MIDUS) survey (N = 3,890) were analyzed using linear mixed models to separate within-person changes from between-person differences. Results indicated that skill discretion and coworker support were positively associated with job-related mental health overall. The hypothesis that the benefits …


Social Capital In The Puerto Rican Deaf Community, Javier Figueroa Quintana Apr 2026

Social Capital In The Puerto Rican Deaf Community, Javier Figueroa Quintana

Theses and Dissertations from DePaul University

There is limited literature regarding the social capital of deaf individuals in the United States (U.S.). There are few studies on deaf individuals in Puerto Rico (P.R.), and none explicitly examines deaf Puerto Ricans’ social capital. This qualitative study aimed to understand and capture the experiences of the deaf Puerto Rican community by focusing on how deaf Puerto Ricans utilize social capital to achieve success. The two main research questions guiding this study are: How have deaf Puerto Ricans utilized social capital to achieve success? What are deaf Puerto Ricans' perceptions of success? This study centers around Yosso's (2005) Community …


The Impact Of Social Support On Somatic Health Symptoms In Emerging Adults: Examining The Role Of Cortisol And Cytokines, Autumn Sharon Rajcevich Schwer Apr 2026

The Impact Of Social Support On Somatic Health Symptoms In Emerging Adults: Examining The Role Of Cortisol And Cytokines, Autumn Sharon Rajcevich Schwer

Theses and Dissertations from DePaul University

There is a wealth of previous research demonstrating that increased levels of social support are associated with mental health benefits, with several potential pathways supported, including social support leading to increased emotional comfort and resilience (Mohan et al., 2024). However, research also demonstrates that increased social support is associated with numerous physical health benefits as well, including lowered risk of chronic disease development and longer lifespans (Hale et al., 2005). But there seems to be a gap in research regarding how social support creates this positive physiological effect. The present study aimed to address this gap and investigate the potential …


Hemispheric Processing Of Conspiracy Theories: The Role Of Inference Constraint And Individual Differences, Abigail Van Nuland Apr 2026

Hemispheric Processing Of Conspiracy Theories: The Role Of Inference Constraint And Individual Differences, Abigail Van Nuland

Theses and Dissertations from DePaul University

This study explored how textual constraint and individual differences influence the hemispheric processing of inferences as individuals read about conspiracy theories. In Study 1, participants judged the likelihood of a conspiracy after reading either a clear cause (i.e., strongly constrained text), a vague cause (i.e., weakly constrained text), or neutral text about a historical event. In addition, several individual difference measures were administered to participants. It was found that participants were more likely to report that official explanations were not accurate (i.e., indicating a possible conspiracy) after reading a vague text compared to a clear text. However, participants who scored …


Mapping The Landscape Of Occupational Health Psychology Research On Immigrant Workers: A Systematic Review, Himali Bhandari Apr 2026

Mapping The Landscape Of Occupational Health Psychology Research On Immigrant Workers: A Systematic Review, Himali Bhandari

Theses and Dissertations from DePaul University

Research on immigrant populations covers a wide range of topics including immigrationpatterns, demographics, working conditions, and occupational health. Nevertheless, studies specifically on immigrant workers within occupational health psychology (OHP) are scattered. To address this inconsistency, this systematic review analyzed OHP research focusing on immigrant workers, highlighting key immigrant characteristics and the psychological theories and frameworks used to explain why and how immigrant workers face high occupational health and safety risks. Peer-reviewed empirical articles were retrieved from APA PsycINFO, APA PsycArticles, and Academic Search Complete using a predefined set of search terms. Qualitative analysis of the included studies (N = 44), …


Youth Perspectives On A Community Program For Children With Special Healthcare Needs: A Qualitative Study Assessing Program Acceptability, Brittany Ricart Apr 2026

Youth Perspectives On A Community Program For Children With Special Healthcare Needs: A Qualitative Study Assessing Program Acceptability, Brittany Ricart

Theses and Dissertations from DePaul University

Objective. A significant number of families have youth with special healthcare needs (CYSHCN). CYSHCN experience dysfunction across multiple life domains, however CYSHCN have also demonstrated significant resilience. Protective factors include social support which can be strengthened through mentoring-based interventions. Team IMPACT is a non-profit organization that matches CYSHCN with college sports teams and includes crucial components, such as social support and mentorship, in a team-sport and community setting. The current study aimed to better understand the acceptability and influence of the Team IMPACT program on youth participants and their health-related behaviors. Methods. Twenty-five participants (mean age = 11.32) completed virtual …


Factors Associated With Objective Neuropsychological Performance In Individuals With Mild Traumatic Brain Injury: A Systematic Review And Meta-Analysis, Kailyn Marie Bare Apr 2026

Factors Associated With Objective Neuropsychological Performance In Individuals With Mild Traumatic Brain Injury: A Systematic Review And Meta-Analysis, Kailyn Marie Bare

Theses and Dissertations from DePaul University

Adults are expected to recover from cognitive symptoms following mild traumatic brain injury (mTBI) within three months; however, a subset report persistent symptoms. Previous meta-analyses have found that these symptoms are due to factors aside from the mTBI itself, and additional research is needed to determine what factors may contribute to objective cognitive functioning in the chronic stage of mTBI. This review examined biopsychosocial and injury-related correlates of objective cognitive functioning in adults with a history of mTBI. A systematic search was conducted in APA PsycINFO, CINAHL, PubMed, SCOPUS, MEDLINE, and SPORTDiscus to identify studies published since 2015 examining associations …


Mentoring Relationship Quality: An Evaluation Of Environmental Risk And Protective Factor Predictors For Urban Black Youth, Brittanie Nicole Gage Apr 2026

Mentoring Relationship Quality: An Evaluation Of Environmental Risk And Protective Factor Predictors For Urban Black Youth, Brittanie Nicole Gage

Theses and Dissertations from DePaul University

Mentoring programs are an important intervention promoting positive developmental outcomes among youth exposed to chronic environmental stressors, particularly Black youth living in underinvested communities. Research has demonstrated moderate positive effects of mentoring on youth outcomes however, less is known about factors influencing mentoring effectiveness. Mentoring relationship quality (MRQ) has emerged as a key component of mentoring effectiveness, suggesting that perceived closeness and support within the relationship can enhance youth outcomes. Less is known regarding the environmental risks and protective factors shaping youths’ ability to engage meaningfully in mentoring relationships. Parent–child relationship quality, exposure to violent stressors, and adaptive and maladaptive …


Neutrophil-Microglia Interaction Drives Motor Dysfunction In A Neuromyelitis Optica Model Induced By Subarachnoid Aqp4-Igg, Fangfang Qi, Vanda A Lennon, Shunyi Zhao, Yong Guo, Husheng Ding, Caiyun Liu, Whitney M Bartley, Tingjun Chen, Claudia F Lucchinetti, Long-Jun Wu Apr 2026

Neutrophil-Microglia Interaction Drives Motor Dysfunction In A Neuromyelitis Optica Model Induced By Subarachnoid Aqp4-Igg, Fangfang Qi, Vanda A Lennon, Shunyi Zhao, Yong Guo, Husheng Ding, Caiyun Liu, Whitney M Bartley, Tingjun Chen, Claudia F Lucchinetti, Long-Jun Wu

Faculty, Staff and Student Publications

Neutrophils and neutrophil extracellular traps (NETs) contribute to early neuromyelitis optica (NMO) histopathology initiated by IgG targeting astrocytic aquaporin-4 (AQP4) water channels. Yet, the mechanisms underlying neutrophil recruitment and their pathogenic roles in disease progression remain unclear. To investigate molecular-cellular events preceding classical complement cascade activation in a mouse NMO model, we continuously infused, via spinal subarachnoid route, a non-complement-activating mouse monoclonal AQP4-IgG. Parenchymal infiltration of netting neutrophils containing C5a ensued with microglial activation and motor impairment but no blood-brain barrier leakage. Motor impairment and neuronal dysfunction both reversed when AQP4-IgG infusion stopped. Two-photon microscopy and electron microscopy-based reconstructions revealed …


Structural Silence: When Ai Infrastructure Fails Speakers Of Underrepresented Languages, Avijit Roy, Proma Roy Apr 2026

Structural Silence: When Ai Infrastructure Fails Speakers Of Underrepresented Languages, Avijit Roy, Proma Roy

Publications and Research

Artificial intelligence tools for education and language support are increasingly framed as scalable responses to access gaps in under-resourced communities. Yet the infrastructure underlying these tools—training corpora, tokenization schemes, evaluation benchmarks, and deployment architectures—encodes a set of assumptions that systematically disadvantages speakers of underrepresented languages before a single model is trained. This paper examines those assumptions through the lens of Bengali, one of the world’s most widely spoken languages with roughly 285 million speakers (Ethnologue, 2025; International Communication and Leadership School, 2026), and the structural barriers that emerge when attempting to build AI-assisted educational tools for Bengali-speaking learners in low-connectivity …