Digital Commons Network^™

Psychological Distress And Social Support Among Community Paediatric Palliative Care Programme Caregivers: Longitudinal Analysis, Esther Chui Yan Wong, Phillip Lung Wai Au-Doung, Yvonne Yuen Ling Chu, Sandy Sin Yuet Wong, Chi Kong Li, Yin Ting Cheung

Faculty, Staff and Students Publications

No abstract provided.

Fuzzy-Weightedzero-Inconsistency, Fwzic,Multi-Criteria Decision Making, Mcdm, Weighting Methods, Fuzzy Set, Mahmood M. Salih, Rasha A. Yousif

Iraqi Journal for Computer Science and Mathematics

Researchers in various fields have consistently used Multi-Criteria Decision-Making (MCDM) methods for discipline improvement, employing both standard and novel approaches. Selecting a weighting mechanismfor evaluation criteriais critical in MCDM problems. Recognizing the importanceofremaining up to date on such developments in methodology, this study aims to review severalinnovative methods integrated with Fuzzy Weighted Zero Inconsistency (FWZIC). Relying onthe papers taken from the significant databases:IEEE Xplore (IEEE), ScienceDirect (SD), Scopus, and PubMed from 23 August 2023 to 30 October 2023, where each method was read and analyzed for its characteristics and steps. These indexes were deemaed extensive and dependable enough to encompass …

Mobile Augmented Reality Framework In Stem Education: A Systematic Literature Review, Danakorn Nincarean Eh Phon, Nur Fatin Razlieya Binti Mohd Razali

Iraqi Journal for Computer Science and Mathematics

There is a growing concern with preparing a sufficient numberof highly qualified professional in areas of Science, Technology, Engineering and Mathematics (STEM). However, the number of students to reach proficiency and pursue in STEM majors seems to be decreasing. Augmented Reality (AR) is one of the evolving technologies that have potential and effect on learning, especially in STEM education. The aim of this paper is to review and analyzeexisting works that are related to AR in STEM Education. In this study, the common design elements, components or features fordesigning educational AR framework in STEM education were analyzed. This paper determined …

Low-Level Resource Partitioning Supports Coexistence Among Functionally Redundant Bacteria During Successional Dynamics, Xiaoqian Annie Yu, Craig Mclean, Jan-Hendrik Hehemann, David Angeles-Albores, Fuqing Wu, Artur Muszyński, Christopher H Corzett, Parastoo Azadi, Elizabeth B Kujawinski, Eric J Alm, Martin F Polz

Faculty, Staff and Student Publications

Members of microbial communities can substantially overlap in substrate use. However, what enables functionally redundant microorganisms to coassemble or even stably coexist remains poorly understood. Here, we show that during unstable successional dynamics on complex, natural organic matter, functionally redundant bacteria can coexist by partitioning low-concentration substrates even though they compete for one simple, dominant substrate. We allowed ocean microbial communities to self-assemble on leachates of the brown seaweed Fucus vesiculosus and then analyzed the competition among 10 taxonomically diverse isolates representing two distinct stages of the succession. All, but two isolates, exhibited an average of 90% ± 6% pairwise …

Pharmacokinetic Changes And Dosage Adjustment Of Digoxin In Elderly Patients With Atrial Fibrillation: A Narrative Review, Mohammed Alfaqeeh, Lanny I. Permatasari, Miski A. Khairinisa, Taofik Rusdiana

Pharmacology and Clinical Pharmacy Research

Digoxin is a cardiac glycoside medication commonly used to control rapid heart rates in Atrial Fibrillation (AF). However, digoxin has a narrow therapeutic range and can be associated with adverse effects, including increased mortality risk, especially in the elderly. Pharmacokinetic changes occur with aging, affecting the way drugs are absorbed, distributed, metabolized, and eliminated from the body. Thus, this narrative review aimed to assess the optimization of digoxin dosing in elderly patients with AF while considering pharmacokinetic changes due to aging. We performed a comprehensive computerized search of relevant English articles and a manual examination of reference lists from primary …

Usability Of Mhealth In Patient With Type 1 And Type 2 Diabetes Mellitus: A Review, Andhara M. Belinda, Tiana Milanda

Pharmacology and Clinical Pharmacy Research

Diabetes mellitus (DM) is a group of metabolic illnesses identified by elevated blood glucose levels. The glycated hemoglobin (HbA1C) test is used to evaluate a person’s control of their blood glucose levels. According to a recent study, mHealth interventions may be particularly helpful for assisting patients with diabetes mellitus to self-monitor their status on their HbA1c level. Therefore, this systematic review aims to provide an overview of how mHealth affects individuals with diabetes mellitus, concentrating on HbA1c evaluation. A systematic review was conducted by reviewing the PubMed, Google Scholar, and Mendeley databases for randomized control trials published between February 2017 …

Positive Effects Of Conservative Religion On The Mental Health Of Sexual Minorities, Jaxon Jessup

Student Works

Sexual minorities often struggle to navigate their sexuality and conservative religious beliefs. Conservative religion is often thought to be toxic for sexual minorities because of the emphasis on traditional marriage (Anderton et al., 2012), and often, the LGBT community will reject sexual minorities that choose to remain in religion (O'Brien, 2007). Conservative religion, however, provides many resources that could benefit sexual (and other) minorities. Religion can help create a sense of identity through teachings and community involvement that may strengthen positive self-perception; it may also create a sense of belonging within a supportive community, especially when individuals are raised among …

Navigating Formula Shortages: Associations Of Parental Perspectives On Transitioning To Alternative Infant Formulas For Cow's Milk Protein Allergy During The 2022 National Formula Shortage, Abigail Fabbrini, Andrew Farrar, Jerry M. Brown, Lea V. Oliveros, Jared Florio, Jesse Beacker, Luke Lamos, Jessica V. Baran, Michael Wilsey

Student Publications

The COVID-19 pandemic led to supply chain disruptions causing a severe shortage of infant formula. The shortage impacted parents of infants with cow’s milk protein allergy (CMPA) who rely on specialized formulas. However, research on parent perspectives during formula shortages is limited. We aimed to understand the factors guiding parents’ decisions when transitioning to alternative amino acid formula (AAF) or extensively hydrolyzed formula (eHF) during the national formula shortage. We conducted a survey using the ZSMoments platform and found that before the shortage, parents valued safety (83%), tolerability (78%), and reputability (78%) as primary factors in selecting eHFs and AAFs. …

The Irish National Chronic Obstructive Pulmonary Disease Quality Improvement Collaborative: An Adaptive Learning Collaborative, Orla Woods, Rachel Macdonell, John Brennan, Lucia Prihodova, Breda Cushen, Richard W Costello, Timothy J Mcdonnell

Faculty, Staff and Student Publications

BACKGROUND: Chronic obstructive pulmonary disease (COPD) is the the most common disease-specific cause of adult emergency hospital admissions in Ireland. Preliminary groundwork indicated that treatment of acute exacerbations of COPD (AECOPD) in Ireland is not standardised between public hospitals. Applying Institute for Healthcare Improvement Breakthrough Series and Model for Improvement methodologies, Royal College of Physicians of Ireland designed and conducted a novel flexible and adaptive quality improvement (QI) collaborative which, using embedded evaluation, aimed to deliver QI teaching to enable teams to implement bespoke, locally applicable changes to improve and standardise acute COPD care at presentation, admission and discharge stages …

Supraventricular Tachycardia Associated With Repeat Cesarean Section Under Spinal Anesthesia, Malik A Althobiani, Rebecca Shuttleworth, John Conway, Jonathan Dainton, Anna Duckworth, Ana Jorge Da Ponte, Jessica Mandizha, Joseph W Lanario, Michael A Gibbons, Sarah Lines, Chris J Scotton, John R Hurst, Joanna C Porter, Anne-Marie Russell

Faculty, Staff and Student Publications

INTRODUCTION: Patients diagnosed with Interstitial Lung Diseases (ILD) use devices to self-monitor their health and well-being. Little is known about the range of devices, selection, frequency and terms of use and overall utility. We sought to quantify patients' usage and experiences with home digital devices, and further evaluate their perceived utility and barriers to adaptation.

METHODS: A team of expert clinicians and patient partners interested in self-management approaches designed a 48-question cross-sectional electronic survey; specifically targeted at individuals diagnosed with ILD. The survey was critically appraised by the interdisciplinary self-management group at Royal Devon University Hospitals NHS Foundation Trust during …

Levodopa Rescues Retinal Function In The Transgenic A53t Alpha-Synuclein Model Of Parkinson's Disease, Katie K N Tran, Vickie H Y Wong, Kirstan A Vessey, David I Finkelstein, Bang V Bui, Christine T O Nguyen

Faculty, Staff and Student Publications

BACKGROUND: Loss of substantia nigra dopaminergic cells and alpha-synuclein (α-syn)-rich intraneuronal deposits within the central nervous system are key hallmarks of Parkinson's disease (PD). Levodopa (L-DOPA) is the current gold-standard treatment for PD. This study aimed to evaluate

METHODS: Anaesthetised 6-month-old mice expressing human A53T alpha-synuclein (HOM) and wildtype (WT) control littermates were intraperitoneally given 20 mg/kg L-DOPA (50 mg levodopa, 2.5 mg benserazide) or vehicle saline (

RESULTS: We found that photoreceptor (a-wave) and bipolar cell (b-wave) ERG responses (

CONCLUSIONS: These findings deepen our understanding of dopamine and alpha-synuclein interactions in the retina and provide a high-throughput preclinical …

Vaccines: A Promising Therapy For Myelodysplastic Syndrome, Kriti Gera, Anjali Chauhan, Paul Castillo, Maryam Rahman, Akash Mathavan, Akshay Mathavan, Elizabeth Oganda-Rivas, Leighton Elliott, John R Wingard, Elias J Sayour

Faculty, Staff and Student Publications

Myelodysplastic neoplasms (MDS) define clonal hematopoietic malignancies characterized by heterogeneous mutational and clinical spectra typically seen in the elderly. Curative treatment entails allogeneic hematopoietic stem cell transplant, which is often not a feasible option due to older age and significant comorbidities. Immunotherapy has the cytotoxic capacity to elicit tumor-specific killing with long-term immunological memory. While a number of platforms have emerged, therapeutic vaccination presents as an appealing strategy for MDS given its promising safety profile and amenability for commercialization. Several preclinical and clinical trials have investigated the efficacy of vaccines in MDS; these include peptide vaccines targeting tumor antigens, whole …

Increased Cysteinyl-Trna Synthetase Drives Neuroinflammation In Alzheimer’S Disease, Xiu-Hong Qi, Peng Chen, Yue-Ju Wang, Zhe-Ping Zhou, Xue-Chun Liu, Hui Fang, Chen-Wei Wang, Ji Liu, Rong-Yu Liu, Han-Kui Liu, Zhen-Xin Zhang, Jiang-Ning Zhou

Faculty, Staff and Student Publications

Background

Microglia-mediated neuroinflammation in Alzheimer’s disease (AD) is not only a response to pathophysiological events, but also plays a causative role in neurodegeneration. Cytoplasmic cysteinyl-tRNA synthetase (CARS) is considered to be a stimulant for immune responses to diseases; however, it remains unknown whether CARS is involved in the pathogenesis of AD.

Methods

Postmortem human temporal cortical tissues at different Braak stages and AD patient-derived serum samples were used to investigate the changes of CARS levels in AD by immunocytochemical staining, real-time PCR, western blotting and ELISA. After that, C57BL/6J and APP/PS1 transgenic mice and BV-2 cell line were used to …

One-Pot Assembly Of Drug-Eluting Silk Coatings With Applications For Nerve Regeneration, Tanner D. Fink, Jessica L. Funnell, Ryan J. Gilbert, R. Helen Zha

Chemical and Biochemical Engineering Faculty Research & Creative Works

Clinical use of polymeric scaffolds for tissue engineering often suffers from their inability to promote strong cellular interactions. Functionalization with biomolecules may improve outcomes; however, current functionalization approaches using covalent chemistry or physical adsorption can lead to loss of biomolecule bioactivity. Here, we demonstrate a novel bottom-up approach for enhancing the bioactivity of poly (l-lactic acid) electro spun scaffolds though interfacial coassembly of protein payloads with silk fibroin into nano thin coatings. In our approach, protein payloads are first added into an aqueous solution with Bombyx mori-derived silk fibroin. Phosphate anions are then added to trigger coassembly of the payload …

D-Mannose Reduces Cellular Senescence And Nlrp3/Gasdermind/Il-1Β-Driven Pyroptotic Uroepithelial Cell Shedding In The Murine Bladder, Chetanchandra S Joshi, Arnold M Salazar, Caihong Wang, Marianne M Ligon, Rayvanth R Chappidi, Bisiayo E Fashemi, Paul A Felder, Amy Mora, Sandra L Grimm, Cristian Coarfa, Indira U Mysorekar

Faculty, Staff and Students Publications

Aging is a risk factor for disease via increased susceptibility to infection, decreased ability to maintain homeostasis, inefficiency in combating stress, and decreased regenerative capacity. Multiple diseases, including urinary tract infection (UTI), are more prevalent with age; however, the mechanisms underlying the impact of aging on the urinary tract mucosa and the correlation between aging and disease remain poorly understood. Here, we show that, relative to young (8-12 weeks) mice, the urothelium of aged (18-24 months) female mice accumulates large lysosomes with reduced acid phosphatase activity and decreased overall autophagic flux in the aged urothelium, indicative of compromised cellular homeostasis. …

Gene Flow And Isolation In The Arid Nearctic Revealed By Genomic Analyses Of Desert Spiny Lizards, Carlos J. Pavón-Vázquez, Qaantah Rana, Keaka Farleigh, Erika Crispo, Mimi Zeng, Jeevanie Liliah, Daniel Mulcahy, Alfredo Ascanio, Tereza Jezkova, Adam D. Leaché, Tomas Flouri, Ziheng Yang, Christopher Blair

Publications and Research

The opposing forces of gene flow and isolation are two major processes shaping genetic diversity. Understanding how these vary across space and time is necessary to identify the environmental features that promote diversification. The detection of considerable geographic structure in taxa from the arid Nearctic has prompted research into the drivers of isolation in the region. Several geographic features have been proposed as barriers to gene flow, including the Colorado River, Western Continental Divide, and a hypothetical Mid-Peninsular Seaway in Baja California. However, recent studies suggest that the role of barriers in genetic differentiation may have been overestimated when compared …

Comparison Of Biomedical Science Students’ Perceptions Of Online Versus Paper-Based Examinations, Elizabeth Winters, Kris Jeremy, William G. Mitchell, Mmf Subhan

School of Biomedical Sciences

Introduction: Online examinations are becoming increasingly incorporated into higher education. However, Biomedical Science students’ perspectives on exam format preferences remains unexplored. This study aims to investigate exam format preferences and attitudes of these students.Methods: A self-reported survey of 31 questions on online exam perceptions was utilized and composed of six dimensions: affective factors, validity, practicality, reliability, security, and pedagogy. Scores measured student attitudes around online exams. Additionally, categorical questions examined attitudes around open-book online exams (OBOEs), closed-book online exams (CBOEs), and paper-based exams (PBEs). Qualitative analysis was conducted via the use of open-ended questions and a focus group on five …

Walk A Mile In My Shoes: Perspectives Towards Sharing Of Health And Experience Data Among Individuals Living With Sickle Cell Disorder, Simon Leigh, Rebecca Baines, Sebastian Stevens, Zainab Garba-Sani, Daniella Austin, Arunangsu Chatterjee

Peninsula Medical School

Background: Advancements in digital health technologies (DHTs) mean people are increasingly recording and managing personal health data. As observed during the COVID-19 pandemic, sharing of such data may provide unrivalled opportunities in advancing our understanding of conditions otherwise poorly understood, including rare conditions. Methods: A semi-structured focus group (n=25) explored perspectives and experiences of sharing health data among those with a group of rare haematological conditions, sickle cell disorder (SCD). The focus group explored (I) what ‘feeling well’ looks like; (II) how this could be monitored using DHTs; (III) which data healthcare professionals (HCPs) should pay greater attention to and; …

History In The Margins: Paratextual Notes In Codex Koridethi (Θ 038), Jonathan Campbell

Andrews University Seminary Studies (AUSS)

In this article I examine the paratextual features of the ninth- century four-Gospel manuscript Codex Koridethi (Θ 038). I argue that a thorough study of this manuscript’s paratextual features gives fascinating insight into its history. There are thirty-three marginal notes contained within this manuscript, nine of which are in Greek, and twenty-four in Georgian. These notes are unusual because they do not relate to the biblical text. Instead, they attest to various prayers, endowments, and laws which the community found important enough to record in this holy book. The notes are broken down into three categories. First, several give historical …

Pioneer Women Administrators In The Interamerican Division Of The Adventist Church (1906–1940), Daniel Alberto Mora

Andrews University Seminary Studies (AUSS)

This article focuses on previously unpublished data concerning pioneer women who helped establish and govern different levels of the Adventist Church between 1906 and 1940 in what is now the Inter-American Division. The article begins with information obtained from different yearbooks, and then traces the identity and work of pioneer Adventist women in documents such as General Conference minutes, newspapers, civil registries, and through information provided by their descendants. It also highlights the contributions of these women as the first local missionaries and founders of the Sabbath School (1880s) and Young People’s Missionary Volunteer (YPMV) (1900s) departments. It also highlights …

The Origin Of Arabic Words In The Ancient Egyptian Language, Deena Alesaily

Journal of the General Union of Arab Archaeologists

أصل الكلمات العربية من اللغة المصرية القديمة [Ar]

يھدف المقال الحالي إلى إجراء دراسة تحلیلیة بناءً على البيانات التي تم جمعها في هذا البحث من اللغة العربية الفصحى، تم تفسير كلمات لغاتها لهذه الدراسة التي نشأت من أصل المصرية القديمة. إلقاء نظرة عميقة على مختلف جوانب الحضارة المصرية القديمة والعديد من جوانب حياتنا المعاصرة يؤكد لنا أن هناك استمرارية بين الماضي والحاضر في العديد من تقاليدنا التي ورثناها، وكذلك بعض المعتقدات الدينية. سيظهر الموروث من أسلافنا بشكل أوضح في لغتنا العربية، مثل أسماء بعض مدننا وقرانا، وبعض المفردات العربية الفصحى المستخدمة في الحياة اليومية. في سياق الاهتمام بإحياء …

Reviving The Ancient Egyptian Festivals As An Authentic Tourism Product, Azza Saad, Mona Taha Hussein, Emad Eddin Abu Elenain

Journal of the General Union of Arab Archaeologists

إحياء المهرجانات المصرية القديمة كمنتج سياحي أصيل [Ar]

تعد المهرجانات من المكونات الأساسية لصناعة السياحة نظرا لأهميتها في الترويج للمقصد السياحي وتعزيز صورته، وأصبحت الأصالة من العناصر الرئيسية التي تؤثر بشكل مباشر على التصنيف العالمي للمنطقة المزارة. و بالرغم من تزايد اعداد الباحتين والدراسين لمفهوم الأصالة في السياحة إلا أن تجربة المهرجانات القديمة لم يتم التطرق إليها. استنادا على تلك الفجوة البحثية، تهدف الدراسة إلى إلقاء الضوء علي الأصالة المتحققة من المهرجانات المصرية القديمة عن طريق دراسة نوعية لتحديد كيفية توظيف تلك الأحداث كوسيلة لترويج السياحة في مصر. وجدير بالذكر أن المهرجانات كانت معروفة في مصر منذ العصور القديمة بل …

The Rhyton Vessel Of Persian And Greek Origins In The Light Of Petosiris Tomb In Tuna El-Gebel (Comparative And Analytical Study), Tony Taleb Abd El Salam

Journal of the General Union of Arab Archaeologists

أواني الريتون ما بين الفارسي واليوناني من خلال مقبرة بيتوزيريس بتونا الجبل دراسة تحليلية مقارنة [Ar]

يعد إناء الريتون من الأواني الهامة التي اسُتخدمت في الاحتفالات والطقوس الدينية كأواني لشرب الماء أو الخمر، ويرجع ظهورها إلي الربع الأخير من القرن الرابع قبل الميلاد في بلاد اليونان، حيث يذكر المؤرخ هيرودوت، بأن اليونانيين عثروا عقب الحروب الفارسية علي كثير من مقتنيات المعسكر الفارسي والتي كانت من بينها أواني الريتون. وتنقسم أواني الريتون من حيث الشكل إلي ثلاثة أنواع، النوع الأول: يتمثل في إناء الريتون المنحني ويكون فيه الإناء ذو قاعدة تُمثل الجزء السفلي من الإناء يعلوها رأس الحيوان التي تُمثل الجزء …

The Inscribed Lintel Of Seshemnefer Discovered Recently At Saqqara, Saleh Soleiman

Journal of the General Union of Arab Archaeologists

العتب المنقوش الخاص بـ سشم نفر المكتشف حديثاً بسقارة [Ar]
يهدف البحث لدراسة عتب منحوت من الحجر الجيري ومكتشف حديثاً بجبانة جسر المدير، غرب هرم ونيس بوسط سقارة، حيث تم وصف العتب وترجمة نصه، بالوصف والترجمة تعليق يرتبط باسم المتوفى ولقبه وصيغة القربان حتب دي نسوت وصيغة برت خرو، كما تم استعراض الاسم الشخصي للمتوفى من حيث النطق والمعني وتاريخ ومكان ظهوره، ودراسة لقب المتوفى من حيث تأريخ ومكان ظهوره واستمراريته، مع أضافة التعليق على نعوت أنوبيس الأربعة الواردة على العتب، وسُجل الشكل الجديد على هذا العتب لكتابة اسم المتوفى، سشم نفر، مع استعراض بداية ظهور صيغة برت خرو نت، …

Evolving Trends In Sustainable Religious Tourism: A Bibliometric Analysis, Anita Kumari, Pooja Thakur

International Journal of Religious Tourism and Pilgrimage

As the world strives to overcome the pressing challenges of sustainable development, the tourism industry, with its substantial environmental and social impacts, calls for renewed attention. Within this domain, religious tourism has emerged as a distinctive and integral component of the sustainable tourism discourse. This study employs bibliometric analysis to examine the growth, key themes, and emerging trends in research on sustainable and religious tourism from the year 2011 to 2022, using the open-access Dimensions database. The findings indicate a continuous and steady growth in the body of literature pertaining to sustainability in religious tourism. The key themes and potential …

A Machine Learning Algorithms For Detecting Phishing Websites: A Comparative Study, Dr. Mohammed A. Taha, Haider D. A. Jabar, Widad K. Mohammed

Iraqi Journal for Computer Science and Mathematics

Phishing website attacks are a type of cyber-attack in which perpetrators create fraudulent websites that mimic legitimate platforms, such as online banking or social media, with the intent of tricking unsuspecting users into divulging sensitive information. This includes passwords, credit card details, usernames, and other personal data. These phishing websites aredesigned to look authentic and often employ various techniques, such as URL spoofing, social engineering, and email or text message phishing, to lure victims into revealing their confidential information. Web apps are growing increasingly complex and difficult to identify at first glance, especially when they use encryption and obfuscation techniques. …

Emotion Recognition Using Various Measures And Computational Methods: Review, Abir Hamrouni, Fatima Bendella

Iraqi Journal for Computer Science and Mathematics

Emotion recognition has garnered significant attention as a burgeoning research domain, owing to its potential applications across diverse fields such ashuman-computer interaction, affective gaming, marketing, and human-robotinteraction.Accurately interpreting and appropriately responding to human emotions remains a critical challenge in the development of systems. This obstacle necessitates a thoroughunderstanding of emotions to enhance user experiences within suchsystems.This paper conducts a comprehensive review focusing on advancements in emotion recognition techniques, with an emphasis on leveraging a variety of sensors and computational methods. Our study findingshighlight the significantimprovement to emotion recognition accuracy when multiple measures and computational methods, rather than a single modality, …

Illuminating The Landscape Of Sibling Relationship Quality: An Evidence And Gap Map, Megan R. Holmes, Anna E. Bender, Kari A. O'Donnell, Emily K. Miller, Ivan T. Conard

Faculty Scholarship

This paper used an evidence and gap map (EGM) to advance the scientific understanding of sibling relationship quality among children aged 2 to 18 years by synthesizing literature on 277 empirical studies from 1985 to 2022 to delineate patterns of study design, sampling, and measurement. Most existing research has utilized majority of White, middle-to-upper class, and/or two-caregiver family samples. Nearly 85% (n = 235) of studies used quantitative methods to measure sibling relationship quality across eight domains: conflict, warmth/affection, quality, cohesion, hostility, power/control, positive engagement, and conflict management. A total of 122 studies used a measure of sibling relationship quality …

Cyp26a1 Links Wnt And Retinoic Acid Signaling: A Target To Differentiate Aldh+ Stem Cells In Apc-Mutant Crc, Caroline O.B. Facey, Victoria O. Hunsu, Chi Zhang, Brian Osmond, Lynn M. Opdenaker, Bruce M. Boman

Department of Pharmacology and Experimental Therapeutics Faculty Papers

APC mutation is the main driving mechanism of CRC development and leads to constitutively activated WNT signaling, overpopulation of ALDH+ stem cells (SCs), and incomplete differentiation. We previously reported that retinoic acid (RA) receptors are selectively expressed in ALDH+ SCs, which provides a way to target cancer SCs with retinoids to induce differentiation. Hypotheses: A functional link exists between the WNT and RA pathways, and APC mutation generates a WNT:RA imbalance that decreases retinoid-induced differentiation and increases ALDH+ SCs. Accordingly, to restore parity in WNT:RA signaling, we induce wt-APC expression in APC-mutant CRC cells, and we assess the ability of …

Taxonomy, Open Challenges, Motivations, And Recommendations In Driver Behavior Recognition: A Systematic Review, Mohamed A. Ahmed, Mohammed Basim Omar, Harith A. Hussein, Z.T Al Qaysi, Mahmood M. Salih, S A. Hamddi, Qabas A. Hameed, Reem D. Ismail

Iraqi Journal for Computer Science and Mathematics

Driver behavior has a major role in many of the unpleasant things that happen when driving, such as crashes or accidents, heavy traffic, abrupt braking, and acceleration and deceleration. Numerous investigations have been carried out to look into the variables influencing driving behavior. To offer a thorough analysis and classify these findings according to a logical classification, further research is required. The goal of this systematic review is to enhance knowledge about the variables influencing driving behavior. A taxonomy on the subject of driver behavior in various ITS domains and their categories was also produced by this work.A systematic review …