Digital Commons Network^™

Retrospective Analysis Of The Impact Of High- And Low-Quality Donor Livers For Patients With High-Acuity Illness, Ron K Varghese, Greta E Handing, Ashley E Montgomery, Abbas A Rana, John A Goss

Faculty, Staff and Students Publications

BACKGROUND Patients with high-acuity liver failure have increased access to marginal and split liver options, owing to historically high waitlist mortality rates. While most research states that donor liver quality has no impact on patients with high-acuity illness, there have been inconsistencies in recent research on how liver quality impacts post-transplant outcomes for these patients. We aimed to quantify donor liver quality with various post-transplantation patient outcomes for patients with high-acuity illness. MATERIAL AND METHODS Using the liver donor risk index (LDRI), model for end stage liver disease (MELD), and clinically relevant recipient factors, we used multivariate logistic regression to …

Pearls & Oy-Sters: Cacna1a-Related Paroxysmal Tonic Upgaze With Ataxia Responsive To Acetazolamide, Steven M Lazar, Farida Abid

Faculty, Staff and Students Publications

A 9-month-old male infant was evaluated for sudden onset of paroxysmal episodes of forced, conjugate upward eye deviation. Extensive in-hospital evaluation including electrophysiology and neuroimaging studies were reassuring against seizures or a structural abnormality. Given the clinical presentation of sudden onset intermittent upward eye deviations, downbeating saccades, associated ataxia, and typical development, a clinical diagnosis of paroxysmal tonic upgaze (PTU) with ataxia was made. Targeted genetic testing of CACNA1A was performed, which revealed a variant of undetermined significance, which was later classified as a de novo pathogenic variant after protein modeling and parental testing performed. Off-label use of oral acetazolamide …

Exploring The Relationship Between Staffing And Long-Term Care Worker Mental Health, Matthew R. Trombley

Doctoral Dissertations and Projects

This research delves into the relationship between staffing levels during a crisis in the healthcare workforce and the mental well-being of long-term care workers, with a specific focus on variables such as burnout, compassion fatigue, and compassion satisfaction. With increasing workforce shortages, the attention to providing quality care during this tumultuous period has become increasingly urgent. There has been scarce empirical research that has explicitly sought to comprehend the connection between staffing levels and the mental health of long-term care professionals. This study was designed as a non-experimental, quantitative correlational investigation, aiming to understand the intricate dynamics between patient-to-staff ratios …

Burnout Triggers In The Novice Registered Nurse, Sharon K. Nguyen

Doctoral Dissertations and Projects

Nurse burnout has been strongly associated with decreased patient satisfaction and reduced retention rates in the novice registered nurse. This phenomenon is exacerbating the already rising global nursing shortage. A strong correlation is established between novice registered nurses who endure repeated or multiple triggers, such as unsafe staffing ratios, inadequate preceptorship, and ineffective leadership to those who succumb to burnout. Burnout is a significant problem in the United States, impacting how healthcare is perceived by the public. In 2019 there were more than six million nurses, making up the largest segment of the healthcare population and directly affecting the safety …

Medication Errors In Hospitals, Isata Jalloh

Doctoral Dissertations and Projects

In hospitals, the issue of medication errors poses a serious problem, often leading to substantial health complications and, in some cases, even deaths among hospitalized as well as discharged patients. This health challenge not only imposes a substantial financial burden on patients, insurance providers, and Federal/State governments but also contributes to elevated healthcare expenses, hindering the effective allocation of resources to address other healthcare issues. Understanding the triggers of medication errors in hospitals is critical in solving this problem. The purpose of this integrative review is to determine the causes/triggers of medication errors in hospitals. This review will highlight the …

The Effects Of Social Gratitude On Anxiety, Depression, And Persistence To Graduate Among College Students, Terrie L. Hilbun

Doctoral Dissertations and Projects

Anxiety and depression have become increasingly prevalent among college students, leading to negative consequences such as decreased persistence to graduate. This study’s goal was to research the effects of a two-week gratitude intervention on attitude health, focusing on gratitude, depression, anxiety, and persistence of college students. The participants were drawn from a convenience sample of community college students located in northeast Alabama. A single pre-and post-test design was utilized, to compare the effects of a social gratitude intervention on gratitude, anxiety, depression, and persistence. A total of 25 volunteers, aged 18 or older, participated. It was hypothesized that there would …

Colliding Worlds: Visual Culture In France And Colonial Algeria (1918-1962), Lacy Murphy

Arts & Sciences Graduate Student Theses and Dissertations

The decline of French colonialism in Algeria and the Algerian War lay at the fault line of several tectonic forces. World War I, World War II, and the Cold War challenged France’s global stature, destabilized the colonial apparatus, and fostered unprecedented intercolonial intellectual exchange. These events provided the global context for Algeria’s national revolution, a prolonged period of conflict that was all in one a civil war that redefined Algerian identity, a political and military scandal that led to the downfall of the French Fourth Republic in 1958, influenced Cold War politics, and continues to shape national identity in both …

The Mental Health Effects Of Vicarious Trauma, Moral Injury, And Positive Religious Coping With Canine Comfort Handlers, Terri Jeanne O'Brien-Cross

Doctoral Dissertations and Projects

The intention of this study was to examine whether positive religious coping buffered the mental health effects of vicarious trauma and moral injuries in canine comfort handlers. By examining whether positive religious coping would reduce symptoms of posttraumatic stress disorder (PTSD), a better understanding of the mental, emotional, and spiritual effects of volunteer handlers was discovered. Handlers work throughout their communities and deploy to crisis events such as mass shootings and natural disasters. By partnering with highly trained canines, they provide support and comfort to those in need. During these interactions, handlers are often exposed to traumatic situations and may …

Tfeb Drives Mtorc1 Hyperactivation And Kidney Disease In Tuberous Sclerosis Complex, Nicola Alesi, Damir Khabibullin, Dean M Rosenthal, Elie W Akl, Pieter M Cory, Michel Alchoueiry, Samer Salem, Melissa Daou, William F Gibbons, Jennifer A Chen, Long Zhang, Harilaos Filippakis, Laura Graciotti, Caterina Miceli, Jlenia Monfregola, Claudia Vilardo, Manrico Morroni, Chiara Di Malta, Gennaro Napolitano, Andrea Ballabio, Elizabeth P Henske

Duncan NRI Faculty and Staff Publications

Tuberous Sclerosis Complex (TSC) is caused by TSC1 or TSC2 mutations, leading to hyperactivation of mechanistic target of rapamycin complex 1 (mTORC1) and lesions in multiple organs including lung (lymphangioleiomyomatosis) and kidney (angiomyolipoma and renal cell carcinoma). Previously, we found that TFEB is constitutively active in TSC. Here, we generated two mouse models of TSC in which kidney pathology is the primary phenotype. Knockout of TFEB rescues kidney pathology and overall survival, indicating that TFEB is the primary driver of renal disease in TSC. Importantly, increased mTORC1 activity in the TSC2 knockout kidneys is normalized by TFEB knockout. In TSC2-deficient …

Prediction Of Hydrogel Degradation Time Based On Central Composite Design, Ying Wang, Deji Liu, Ruiquan Liao, Guangming Zhang, Manlai Zhang, Xiaohui Li

Faculty, Staff and Student Publications

In this study, a self-degrading hydrogel was formed by free-radical-initiated copolymerization, which can be used for oil and gas well strip pressure operations. Fourier transform infrared spectroscopy (FTIR), nuclear magnetic resonance (1H NMR), scanning electron microscopy (SEM), and thermogravimetry-mass spectrometry (TGA-MS) were used to study the reaction mechanism as well as the microstructure of the gels. Then, the effects of the four factors and their interactions on gel degradation time were determined by central composite design (CCD). Then, the effects of copolymer concentration, cross-linker, initiator, and reaction temperature and their interactions on gel degradation time were determined by central composite …

Toward Standardization, Harmonization, And Integration Of Social Determinants Of Health Data: A Texas Clinical And Translational Science Award Institutions Collaboration, Catherine K Craven, Linda Highfield, Mujeeb Basit, Elmer V Bernstam, Byeong Yeob Choi, Robert L Ferrer, Jonathan A Gelfond, Sandi L Pruitt, Vaishnavi Kannan, Paula K Shireman, Heidi Spratt, Kayla J Torres Morales, Chen-Pin Wang, Zhan Wang, Meredith N Zozus, Edward C Sankary, Susanne Schmidt

Faculty, Staff and Student Publications

INTRODUCTION: The focus on social determinants of health (SDOH) and their impact on health outcomes is evident in U.S. federal actions by Centers for Medicare & Medicaid Services and Office of National Coordinator for Health Information Technology. The disproportionate impact of COVID-19 on minorities and communities of color heightened awareness of health inequities and the need for more robust SDOH data collection. Four Clinical and Translational Science Award (CTSA) hubs comprising the Texas Regional CTSA Consortium (TRCC) undertook an inventory to understand what contextual-level SDOH datasets are offered centrally and which individual-level SDOH are collected in structured fields in each …

The Experience Of Physical Recovery And Physical Rehabilitation Following Hospital Discharge For Intensive Care Survivors—A Qualitative Systematic Review, Sian Goddard, Hilary Gunn, Bridie Kent, Rachel Dennett

School of Health Professions

Background: Over 120,000 people in the UK survive critical illness each year, with over 60% of these experiencing mobility issues and reduced health-related quality of life after discharge home. This qualitative systematic review aimed to explore critical care survivors’ perceptions, opinions, and experiences of physical recovery and physical rehabilitation following hospital discharge. Methods: This review followed the Joanna Briggs Institute (JBI) methodology with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and was conducted between January 2020 and June 2022. The search was conducted using the following databases: Embase, CINAHL, Medline Ovid, Cochrane, and the Joanna Briggs Institute, …

Comparing The Effectiveness Of Static And Dynamic Audiovisual In An Additional Geography Lesson In One Pathway College In Jakarta, Erni Adelina, Peny Meliaty Hutabarat

Jurnal Vokasi Indonesia

Students are now used to using audiovisual platforms to learn as they once were forced to adapt to this type of learning due to face-to-face lessons were impossible at that time because of the pandemic. Audiovisual learning resources came out sporadically to accommodate the needs of study at home or anywhere possible. The static audiovisual (enhanced podcast) and dynamic audiovisual (video) are two types of virtual platforms educators continuously harness to support their lesson teachings even though the face-to-face meetings have been allowed gradually. However, there are not many studies conducted to analyze whether one type is more effective in …

From Panels To Shelves: The Evolving Intersection Of Comics And Italian Libraries. History, Issues, Perspectives, Andrea Tosti

SANE journal: Sequential Art Narrative in Education

Despite comics' popularity and cultural significance in Italy, its integration into Italian libraries has been slow, problematic, and uneven. This is reflected in the scarcity of academic research on the topic, which demands further in-depth exploration.

In the context of Italian libraries, characterized by chronic underfunding and staffing shortages, comics might be perceived as a low priority. However, as essential cultural institutions, libraries must strive to reflect both the contemporary era and the evolving reading habits of their audience. Comics, in this regard, could prove to be – and in part already are – a critical resource, a 'booster' for …

The Utah Statesman, January 8, 2024, Utah State University

The Utah Statesman

Weekly student newspaper of Utah State University in Logan.

Biotic Interactions Vary Across Species' Ranges And Are Likely Conserved Through Geological Time, Iulian Gherghel, Ryan Andrew Martin

Faculty Scholarship

Aim: The evolutionary interactions between western spadefoot toads (genus Spea) represent a textbook example of character displacement, facilitated by dietary specialization of one Spea species on fairy shrimp (Anostraca) when all three co-occur. The aim of this study is to understand the covariation between predator (Spea) and prey (Anostraca) range shifts in response to climate change oscillations, and whether biotic interactions can be used to project species distribution models on different time scales when studying species with dietary specialization. Taxon: Amphibia: Spea spp. and Crustacea: Anostraca. Location: North America. Methods: Using multiple modelling techniques, we first estimated the potential distribution …

Refugee Health In Philadelphia, Marc Altshuler, Md

Academic Commons Workshops and Presentations

No abstract provided.

Strategies And Resources For Integrating Technology Into The Secondary Education World Language Classroom, Angelina M. Bauer

Masters Projects

This document is a research-based project that includes a reference manual of strategies for technology integration in the World Language curriculum, as well as an example lesson plan that implements many of the strategies. Many of the strategies and examples can be adapted to fit multiple subject areas. The theoretical framework upon which the project is constructed is a combination of TPACK and several of Stephen Krashen's Theories of Second Language Acquisition.

Development Of An Anisotropic Hyperelastic Material Model For Porcine Colorectal Tissues, Youssef Fahmy, Mohamed B. Trabia, Brian Ward, Lucas Gallup, Mary Froehlich

Mechanical Engineering Faculty Research

Many colonic surgeries include colorectal anastomoses whose leaks may be life-threatening, affecting thousands of patients annually. Various studies propose that mechanical interaction between the staples and neighboring tissues may play an important role in anastomotic leakage. Therefore, understanding the mechanical behavior of colorectal tissue is essential to characterizing the reasons for this type of failure. So far, experimental data characterizing the mechanical properties of colorectal tissue have been few and inconsistent, which has significantly limited understanding their behavior. This research proposes an approach to developing an anisotropic hyperelastic material model for colorectal tissues based on uniaxial testing of freshly harvested …

Using Fisheries-Dependent Data To Investigate Landings Of European Lobster (Homarus Gammarus) Within An Offshore Wind Farm, Harry Thatcher, Thomas Stamp, Pippa J Moore, David Wilcockson, Silvana Birchenough

School of Biological and Marine Sciences

The need for alternative strategies to assist in the monitoring and sustainable management of fisheries’ resources is becoming increasingly important. In recent years, greater utilization of fishers’ knowledge has been advocated as a potentially valuable source of data that could be applied to fisheries management issues. In the current study, we addressed this by investigating the landing per unit effort (LPUE) of European lobster (Homarus gammarus) from within an offshore wind farm using a fisheries-dependent commercial fishing logbook. The logbook was provided by a single fisherman who targeted lobsters within the wind farm between 2015 and 2022 using single pots …

Variants In The Wdr44 Wd40-Repeat Domain Cause A Spectrum Of Ciliopathy By Impairing Ciliogenesis Initiation, Andrea Accogli, Saurabh Shakya, Taewoo Yang, Christine Insinna, Soo Yeon Kim, David Bell, Kirill R Butov, Mariasavina Severino, Marcello Niceta, Marcello Scala, Hyun Sik Lee, Taekyeong Yoo, Jimmy Stauffer, Huijie Zhao, Chiara Fiorillo, Marina Pedemonte, Maria C Diana, Simona Baldassari, Viktoria Zakharova, Anna Shcherbina, Yulia Rodina, Christina Fagerberg, Laura Sønderberg Roos, Jolanta Wierzba, Artur Dobosz, Amanda Gerard, Lorraine Potocki, Jill A Rosenfeld, Seema R Lalani, Tiana M Scott, Daryl Scott, Mahshid S Azamian, Raymond Louie, Hannah W Moore, Neena L Champaigne, Grace Hollingsworth, Annalaura Torella, Vincenzo Nigro, Rafal Ploski, Vincenzo Salpietro, Federico Zara, Simone Pizzi, Giovanni Chillemi, Marzia Ognibene, Erin Cooney, Jenny Do, Anders Linnemann, Martin J Larsen, Suzanne Specht, Kylie J Walters, Hee-Jung Choi, Murim Choi, Marco Tartaglia, Phillippe Youkharibache, Jong-Hee Chae, Valeria Capra, Sung-Gyoo Park, Christopher J Westlake

Faculty, Staff and Students Publications

WDR44 prevents ciliogenesis initiation by regulating RAB11-dependent vesicle trafficking. Here, we describe male patients with missense and nonsense variants within the WD40 repeats (WDR) of WDR44, an X-linked gene product, who display ciliopathy-related developmental phenotypes that we can model in zebrafish. The patient phenotypic spectrum includes developmental delay/intellectual disability, hypotonia, distinct craniofacial features and variable presence of brain, renal, cardiac and musculoskeletal abnormalities. We demonstrate that WDR44 variants associated with more severe disease impair ciliogenesis initiation and ciliary signaling. Because WDR44 negatively regulates ciliogenesis, it was surprising that pathogenic missense variants showed reduced abundance, which we link to misfolding of …

Designing And Implementing An Ecg Reader And Heart Disease Classification Device Using Deep Learning (Comprehensive Review), Ghasaq Saad Jameel, M N. Al-Turfi, Dr. Hussain Falih Mahdi, Saba Nasser Hussain

Iraqi Journal for Computer Science and Mathematics

Cardiovascular cases remain a significant health care concern, necessitating new development methods for their prompt and accurate identification where a promising advancements is demonstrated using Deep Learning (DL) in automating heart anomalies detection, including irregular heartbeats, heart attacks, and abnormal heart rhythms, through the analysis of electrocardiogram (ECG) signals, which guided this article to explore the integration of DL methodologies in examining ECG data to enhance the diagnosis of various cardiac ailments and delves into the development of novel ECG devices designed to facilitate efficient data acquisition while ensuring patient comfort and accessibility.The devices used must provide real-time monitoring, seamless …

Faculty Senate Agenda January 8, 2024, Utah State University

Faculty Senate & Faculty Senate Executive Committee

• 3:00 Call to Order
• 3:05 University Business
• 3:20 Faculty Senate Business
• 3:30 Information

• 3:35 Reports

• 4:00 Old Business

• 4:05 New Business

• Adjourn: 4:30

Associations Between Coordination And Wearable Sensor Variables Vary By Recording Context But Not Assessment Type, Jeffrey D Konrad, Natasha Marrus, Keith R Lohse, Kayla M Thuet, Catherine E Lang

2020-Current year OA Pubs

Motor coordination is an important driver of development and improved coordination assessments could facilitate better screening, diagnosis, and intervention for children at risk of developmental disorders. Wearable sensors could provide data that enhance the characterization of coordination and the clinical utility of that data may vary depending on how sensor variables from different recording contexts relate to coordination. We used wearable sensors at the wrists to capture upper-limb movement in 85 children aged 6-12. Sensor variables were extracted from two recording contexts.

Achieving Reliable Patient Reported Outcomes Collection To Measure Health Care Improvement In A Learning Health Network: Lessons From Pediatric Rheumatology Care And Outcomes Improvement Network., Nancy Pan, Esi M. Morgan, Meghan Ryan, Beth Gottlieb, Julia G. Harris, Tzielan Lee, Y Ingrid Goh

Manuscripts, Articles, Book Chapters and Other Papers

INTRODUCTION: Data from the Pediatric Rheumatology Care and Outcomes Improvement Network (PR-COIN) registry suggests that reliable collection of patient-reported outcomes (PROs) varies across sites. The objective of this study was to better understand the practices of collecting PROs at PR-COIN sites.

METHODS: A REDCap survey was sent to the lead representative for each PR-COIN site. Registry data were analyzed to better understand the completion rates of PROs. Interviews of physician leaders of high performing sites were conducted by videoconference, audiotranscribed and themes were summarized. Quantitative data were analyzed using descriptive statistics and qualitative data were thematically analyzed.

RESULTS: All 23 …

Developmental Basis Of Shh Medulloblastoma Heterogeneity, Maxwell P Gold, Winnie Ong, Andrew M Masteller, David R Ghasemi, Julie Anne Galindo, Noel R Park, Nhan C Huynh, Aneesh Donde, Veronika Pister, Raul A Saurez, Maria C Vladoiu, Grace H Hwang, Tanja Eisemann, Laura K Donovan, Adam D Walker, Joseph Benetatos, Christelle Dufour, Livia Garzia, Rosalind A Segal, Robert J Wechsler-Reya, Jill P Mesirov, Andrey Korshunov, Kristian W Pajtler, Scott L Pomeroy, Olivier Ayrault, Shawn M Davidson, Jennifer A Cotter, Michael D Taylor, Ernest Fraenkel

Faculty, Staff and Students Publications

Many genes that drive normal cellular development also contribute to oncogenesis. Medulloblastoma (MB) tumors likely arise from neuronal progenitors in the cerebellum, and we hypothesized that the heterogeneity observed in MBs with sonic hedgehog (SHH) activation could be due to differences in developmental pathways. To investigate this question, here we perform single-nucleus RNA sequencing on highly differentiated SHH MBs with extensively nodular histology and observed malignant cells resembling each stage of canonical granule neuron development. Through innovative computational approaches, we connect these results to published datasets and find that some established molecular subtypes of SHH MB appear arrested at different …

The Million Veteran Program 1990-1991 Gulf War Era Survey: An Evaluation Of Veteran Response, Characteristics, And Representativeness Of The Gulf War Era Veteran Population, Kelly M Harrington, Rachel Quaden, Lea Steele, Drew A Helmer, Elizabeth R Hauser, Sarah T Ahmed, Mihaela Aslan, Krishnan Radhakrishnan, Jacqueline Honerlaw, Xuan-Mai T Nguyen, Sumitra Muralidhar, John Concato, Kelly Cho, J Michael Gaziano, Stacey B Whitbourne, On Behalf Of The Va Million Veteran Program

Center for Medical Ethics and Health Policy Staff Publications

To address gaps in understanding the pathophysiology of Gulf War Illness (GWI), the VA Million Veteran Program (MVP) developed and implemented a survey to MVP enrollees who served in the U.S. military during the 1990–1991 Persian Gulf War (GW). Eligible Veterans were invited via mail to complete a survey assessing health conditions as well as GW-specific deployment characteristics and exposures. We evaluated the representativeness of this GW-era cohort relative to the broader population by comparing demographic, military, and health characteristics between respondents and non-respondents, as well as with all GW-era Veterans who have used Veterans Health Administration (VHA) services and …

Facilitating Interdisciplinary Team Response For Addressing Ftic Student Covid-Era Needs, Catherine Robert, Kimshi Hickman, Marilee Bresciani Ludvik

SAGE Open Access Agreement Publications-Archive

Designing first-year experiences for first-time in college students (FTICs) is challenging and the Covid-19 pandemic created additional issues for university professionals striving to support them. In 2020–21, universities struggled with a decrease in FTIC enrollment and first-year term-to-term persistence. Even with a plan to collect academic and psychological well-being predictive data in the summer, student success professionals, faculty, and data analysts knew little about how the use of that data would best serve first-year students entering college during the pandemic. This article describes a unique interdisciplinary response that one Hispanic Serving Institution (HSI) engaged in for creating an intervention plan …

Trustee's Objection To Debtor's First Amended Disclosure Statement

Catholic Dioceses in Bankruptcy

No abstract provided.

Physics 100 Level Laboratory Data Collection Tables, Kalani Hettiarachchilage

Open Educational Resources

The physics 100-level laboratory part demonstrates and applies the material learned from related classes. This document shows guidelines for collecting data and analyzing them by using Microsoft Excel. Laboratory components of PHY 114/ PHY 206/SLS 261 (Introduction to Physics and Nature of Physical Processes), PHY116/PHY 121 (Physics I and General Physics I), and PHY 156/PHY 161 (Physics II and General Physics II) at College of Staten Island are in-person mandatory sessions for students and it is required to pass to receive a passing grade for that class. This part is taught by different instructors. Although everyone is supposed to follow …