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Articles 13141 - 13170 of 1439291
Full-Text Articles in Entire DC Network
Association Between Superstition Levels On Sports-Specific Success Motivation In Active Athletes: A Study In Ankara Province , Canan Sayin Temur
Association Between Superstition Levels On Sports-Specific Success Motivation In Active Athletes: A Study In Ankara Province , Canan Sayin Temur
Turkish Journal of Medical Sciences
Background/aim: When athletes perceive themselves as strong, they may seek to maintain their motivation through the control of random external factors. The present study examines the effect of superstitions on sports-specific success motivation among active athletes.
Materials and methods: The research population consisted of licensed athletes in the athletics branch, while the sample comprised licensed and active athletes based in Ankara. A total of 408 athletes participated in the research, including 201 women, and 207 men. The participants completed a three-part questionnaire consisting of a Personal Information Form, the Motivation in Sports Scale, and the Superstitious Beliefs and Behaviors in …
Clinical Applications Of Topical Platelet-Rich Plasma In Cardiac Surgery: A Scoping Review, Jaron M. Davis
Clinical Applications Of Topical Platelet-Rich Plasma In Cardiac Surgery: A Scoping Review, Jaron M. Davis
Student Works
Background: Postoperative wound complications persist as a significant challenge within adult cardiac surgery. Deep and superficial sternal wound infections, along with complications at saphenous vein harvest sites, are linked to increased morbidity, extended hospital stays, and substantial healthcare expenses. Topical platelet-rich plasma (PRP), commonly known as platelet gel, has been suggested as a biologically active adjunct that may facilitate tissue repair and mitigate postoperative complications. While PRP has garnered attention in surgical practice, the overall scope and consistency of the supporting evidence in cardiac surgery remain ambiguous.
Objective: The purpose of this scoping review is to map and describe the …
Sulfuric Acid Mist Generation, Calculation, And Suppression Mechanism And Methods In Electrowinning: A Review, Ashish Kakoria, Mirza Muhammad Zaid, Guang Xu
Sulfuric Acid Mist Generation, Calculation, And Suppression Mechanism And Methods In Electrowinning: A Review, Ashish Kakoria, Mirza Muhammad Zaid, Guang Xu
Mining Engineering Faculty Research & Creative Works
This review discusses the events of acid mist production at the final stage of hydrometallurgical metal production in copper electrowinning. This review entails the complete process of oxygen bubble generation on the anode and its stages to form into acid mist at the surface of the electrolyte. When these bubbles burst at the solution/air interface, fine acid-containing liquid droplets become airborne and spread throughout the workspace, with the impact factors suppressing the acid mist produced during the process. Also, parameters such as bubble size, temperature, surface tension, and visco-elasticity also affect the acid mist. Sulfuric acid affects the tank houses …
2026 Academic & Creative Excellence Reception Program, Lynn University
2026 Academic & Creative Excellence Reception Program, Lynn University
Academic and Creative Excellence (ACE) Reception Programs
The program for the 2026 Academic and Creative Excellence (ACE) Reception - the 18th annual - organized by the Lynn Library, working in conjunction with the Office of Academic Affairs. The reception was held Tuesday, April 14 in the Salon at the Keith C. and Elaine Johnson Wold Performing Arts Center.
The Faculty Scholarship and Creative Activities Award is presented to Dr. Roberta Rust.
Alumna Turns Gratitude Into Opportunity For Journalism Students, Michael Newsom
Alumna Turns Gratitude Into Opportunity For Journalism Students, Michael Newsom
University of Mississippi News
OXFORD, Miss. – As a broadcast journalism student at the University of Mississippi, Ashley Anderson Mattei spent late nights in the newsroom, learning by doing and making real decisions that mirror the demands of professional media leadership.
The Impact Of An Interactive Open Education Textbook For An Undergraduate Introductory Chemistry Course For Nonmajors, Erin Avram
Chemistry Faculty Publications
Reading informational text is a critical skill across most professions. Unfortunately, students are less likely to purchase the required course materials now compared to 2010. A free, interactive text was developed for an introductory chemistry course for non-STEM majors. This involved remixing existing texts and incorporating interactive activities to engage students during the learning process and provide opportunities for them to gauge their learning. Based on the results of a student survey, 82% of students reported that it was very important to them that the text was free and 80% of students who responded reported that they used the eText …
Engineering Ferrate(Vi) For Water And Wastewater Treatment: Translating Science Into Technology, Zepei Tang, Zhenli He, Yang Deng
Engineering Ferrate(Vi) For Water And Wastewater Treatment: Translating Science Into Technology, Zepei Tang, Zhenli He, Yang Deng
Department of Earth and Environmental Studies Faculty Scholarship and Creative Works
Over the past five decades, ferrate(VI) (FeO42–) for water and wastewater treatment has remained largely at the laboratory scale, with limited pilot- and full-scale implementation. This gap between sustained research and scarce real-world deployment places the technology in the Valley of Death─a high-risk stage of development─and highlights the need for an engineering-centric approach to enable practical application. This article presents an engineering framework to guide the development and translation of ferrate(VI) technology for water and wastewater treatment. From a system perspective, ferrate(VI) technology comprises three core subsystems: generation, treatment, and solid–liquid separation. Technology maturity depends on both the advancement of …
Johnson & Johnson V. Samsung Bioepis Co Ltd
Johnson & Johnson V. Samsung Bioepis Co Ltd
2026 Decisions
USDC for the District of New Jersey
Coverage, Traits, And Geographic Distribution Of Online Surgeon Reviews: Large-Scale Cross-Sectional Analysis, Michael Geng, Carlos Riveros, Yash B. Shah, Sanjana Ranganathan, Kai Fok, Renil Sinu Titus, Vatsala Mundra, Eusebio Luna Velasquez, Dharam Kaushik, Allan S. Detsky, Angela Jerath, Benjamin N. Breyer, Yusuke Tsugawa, Christopher J. D. Wallis, Raj Satkunasivam
Coverage, Traits, And Geographic Distribution Of Online Surgeon Reviews: Large-Scale Cross-Sectional Analysis, Michael Geng, Carlos Riveros, Yash B. Shah, Sanjana Ranganathan, Kai Fok, Renil Sinu Titus, Vatsala Mundra, Eusebio Luna Velasquez, Dharam Kaushik, Allan S. Detsky, Angela Jerath, Benjamin N. Breyer, Yusuke Tsugawa, Christopher J. D. Wallis, Raj Satkunasivam
Student Papers, Posters & Projects
BACKGROUND: The use of online physician rating platforms has significantly increased and has been shown to influence physician selection. There are limited data on the use of these platforms for rating surgeons.
OBJECTIVE: In this study, we sought to assess the geographic distribution of and patterns in rating scores of surgeons in the United States. Additionally, we examined rating volumes across different surgical specialties and the association between peer-nominated and patient-initiated ratings on online rating platforms in the United States.
METHODS: We conducted a cross-sectional study by identifying 201,154 surgeons in the United States via the National Plan and Provider …
Dasatinib And Quercetin Senolytic Treatment Delays Early Onset Intervertebral Disc Degeneration In Sm/J Mice, Emanuel J. Novais, Olivia K. Ottone, Sanjana Jagannath, Esther Jesutofunmi Akande, Makarand V. Risbud
Dasatinib And Quercetin Senolytic Treatment Delays Early Onset Intervertebral Disc Degeneration In Sm/J Mice, Emanuel J. Novais, Olivia K. Ottone, Sanjana Jagannath, Esther Jesutofunmi Akande, Makarand V. Risbud
Department of Orthopaedic Surgery Faculty Papers
Genetic background is a major determinant of disc degeneration, a leading cause of chronic back pain and disability. Herein, we demonstrate that premature disc cell senescence contributes to early-onset degeneration in SM/J mice and test two systemic senotherapeutic strategies to mitigate it: Navitoclax (Nav.) and a cocktail of Dasatinib and Quercetin (DQ). While Nav. treatment did not improve severe degeneration in SM/J mice or senescence status, DQ-treated mice showed lower grades of degeneration and a decreased abundance of senescence markers, including p19ARF, p21, and the senescence-associated secretory phenotype (SASP). DQ improved disc cell viability and phenotype retention and retarded fibrosis …
Hester's Dubious Roots And Legacy: Open Fields Doctrine Under Scrutiny, Laura K. Donohue
Hester's Dubious Roots And Legacy: Open Fields Doctrine Under Scrutiny, Laura K. Donohue
Texas A&M Law Review
For over a century, open fields doctrine has shaped Fourth Amendment law, denying people the right to be secure on their own property. Its impact has steadily expanded, with the result that, by some estimates, the government can now engage in warrantless surveillance of some 96% of private land and buildings regardless of fences, postings, the distance from public roads or byways, or the use to which the property is put. An originalist approach throws the doctrine into disarray: at the time of the Founding, common law protected the curtilage, which extended to the fields, barns, storehouses, and other buildings …
Regulating Data Monetization, Peter Ormerod
Regulating Data Monetization, Peter Ormerod
Texas A&M Law Review
Companies today generate hundreds of billions of dollars each year by collecting massive amounts of information about human activity and wringing predictive insights from it. The scale of these influence activities is stunning: your driving habits dictate your car insurance rates, buying the wrong thing will increase your borrowing costs, and the information ecosystem you inhabit is finely tuned for keeping your attention available to the highest bidder.
States have recently enacted new consumer privacy laws that confer on individuals a series of generally applicable rights over their personal information. But this approach has proven ineffective at disciplining firms’ data …
Antitrust & The Immoral Energy Economy, Kristen Van De Biezenbos
Antitrust & The Immoral Energy Economy, Kristen Van De Biezenbos
Texas A&M Law Review
The age of climate change is upon us, but regulations and programs intended to decarbonize the electricity sector have been effectively stymied by utilities defending their monopoly power. The lack of robust antitrust enforcement against the utilities to date is a result of the belief that regulation is sufficient to police monopoly anticompetitive activity, that the natural monopoly structure of utilities makes them a poor fit for antitrust principles, and that the utilities are immune from Sherman Act claims under the state action exemption. But these rationales reflect a misunderstanding of the purpose of public utility law and its preference …
Hybrid Bermudagrass Dormancy Management In A Cool-Season Climate, Clarissa H. Peterson
Hybrid Bermudagrass Dormancy Management In A Cool-Season Climate, Clarissa H. Peterson
Theses and Dissertations
Hybrid bermudagrass (Cynodon dactylon [L.] Pers. × C. transvaalensis Burtt Davy) (HBG) is a water efficient warm-season turfgrass increasingly adopted in cool-season and semi-arid regions due to climate change and the demand for reduced irrigation inputs. However, prolonged winter dormancy limits its visual quality (verdure) and seasonal performance. This thesis evaluated multiple management strategies to modify dormancy dynamics and improve off-season turf quality in a cool-season environment. Field experiments assessed the effects of growth covers, fertilizers, colorants, surfactants, organic acids, and overseeding with cool-season species on HBG dormancy over two seasons. Dormancy responses were quantified using normalized difference vegetation index …
From Beauty To Burden: Mapping The Health And Psychosocial Impacts Of Fragrances And Cosmetic Products Use In The Uae, Sharifa Alblooshi, Mariam Al Ali, Dana N. Abdelrahim, Suheir Awadalla
From Beauty To Burden: Mapping The Health And Psychosocial Impacts Of Fragrances And Cosmetic Products Use In The Uae, Sharifa Alblooshi, Mariam Al Ali, Dana N. Abdelrahim, Suheir Awadalla
All Works
Background The dynamic beauty care sector in the Middle East is on an upward trend in the UAE; however, concerns persist about the side effects of this industry, attributed to chemical exposure, which is believed to contribute to skin problems and other health issues. In the UAE, there is a lack of data on consumer usage, awareness, and the health effects associated with it.Methods This study presents the results of an online survey administered to 461 female subjects in the United Arab Emirates as part of a cross-sectional study. The survey consisted of 55 questions on product use, knowledge, attitudes, …
Knowledge, Attitude And Practice Towards Sarcopenia Among Diabetic Patients Attending Outpatient Department Of A Tertiary Care Centre In Kerala, India, Vysakh Ts, Ajas Sn, Asha Raby N
Knowledge, Attitude And Practice Towards Sarcopenia Among Diabetic Patients Attending Outpatient Department Of A Tertiary Care Centre In Kerala, India, Vysakh Ts, Ajas Sn, Asha Raby N
Muthanna Medical Journal
Background: Sarcopenia is a progressive skeletal muscle disorder increasingly seen in individuals with diabetes, leading to functional decline and poor quality of life. Despite Kerala's high diabetes burden, sarcopenia remains underrecognized. This study assessed knowledge, attitude, and practice (KAP) regarding sarcopenia among diabetic patients and examined inter-domain relationships. Methods: A 6-month institutional cross-sectional study was conducted in the Family Medicine outpatient department of St. Joseph's Hospital Trust, Kochi. Using consecutive sampling, 154 diabetic patients (type 1 or 2) aged ≥ 40 years were enrolled. Data were collected using a pilot-tested questionnaire covering sociodemographic and clinical details, knowledge (12 items), attitude …
Prognostic Significance And Clinicopathological Associations Of Tumor Budding And Poorly Differentiated Clusters In Endometrioid Endometrial Carcinoma , Hani̇fe Seda Mavi̇li̇, Ömer Atmiş, Fatma Seher Pehli̇van, Fatma Sezen Çavdaroğlu Deveci̇, Ali̇ Riza Kandi̇loğlu
Prognostic Significance And Clinicopathological Associations Of Tumor Budding And Poorly Differentiated Clusters In Endometrioid Endometrial Carcinoma , Hani̇fe Seda Mavi̇li̇, Ömer Atmiş, Fatma Seher Pehli̇van, Fatma Sezen Çavdaroğlu Deveci̇, Ali̇ Riza Kandi̇loğlu
Turkish Journal of Medical Sciences
Background/aim: Tumor budding (TB) and poorly differentiated clusters (PDCs) are histopathological parameters that have been associated with poor prognosis in various malignancies, particularly colorectal carcinoma. Although numerous studies have demonstrated an association between the microcystic, elongated, and fragmented (MELF) pattern in endometrial carcinomas and lymphovascular invasion as well as lymph node metastasis, the literature regarding TB and PDCs in this context remains limited. This study aimed to investigate the potential associations of the MELF pattern, TB, and PDCs with overall survival, progression-free survival, and clinicopathological parameters in cases of endometrioid endometrial carcinoma (EEC).
Materials and methods: A total of 190 …
Hypertext Transfer Protocol Fingerprinting: Techniques For Attacker-In-The-Middle Proxy Detection, Evasion, And Counter-Evasion, Jensen George Wood
Hypertext Transfer Protocol Fingerprinting: Techniques For Attacker-In-The-Middle Proxy Detection, Evasion, And Counter-Evasion, Jensen George Wood
Theses and Dissertations
Attacker-in-the-middle (AitM) phishing toolkits have emerged as a critical threat to enterprise and individual security by enabling adversaries to bypass multi-factor authentication (MFA) and compromise cloud-based accounts at scale. Traditional detection techniques--such as IP blocklists or content-based detection methods--are often ineffective against these increasingly sophisticated attacks. We propose a novel method that detects malicious proxies by identifying artifacts they introduce into HTTP request headers. To evaluate our approach, we systematically analyze traffic passed through several open-source AitM toolkits and proxies, identifying distinct modifications to header structures and content, then formalize these features as YARA rules for automated use. To validate …
Language And Emotional Experience: A Worldwide Study, Natalie Lorange, Chelsea Romney
Language And Emotional Experience: A Worldwide Study, Natalie Lorange, Chelsea Romney
FHSS Mentored Research Conference
This qualitative study explored how native language influences emotional experience. Fourteen participants from diverse countries were recruited to capture a range of linguistic perspectives and experiences. Data were analyzed using thematic analysis, resulting in four key themes: (1) shared experience as central in creating emotional meaning, (2) the power of words in shaping emotional experience, (3) stronger emotional resonance in native or frequently used languages, and (4) the importance of regional differences in emotional experience. Findings suggest that while emotions may be largely universal, linguistic and cultural differences play a significant role in an individual's emotional identity. The study highlights …
Advancing Hand Therapy Practice Through Specialized Clinical Reasoning And Patient Education, Candace Heinlein
Advancing Hand Therapy Practice Through Specialized Clinical Reasoning And Patient Education, Candace Heinlein
Capstone Projects
This doctoral capstone experience (DCE) was completed at Corewell Health Grand Rapids Hospitals Hand Therapy Clinic and focused on two ACOTE concentration areas including advanced clinical practice skills and education. The experience combined hands-on clinical practice in a specialized outpatient hand therapy setting with the development of high-quality client education materials and home exercise programs (HEPs). Objectives were created to address identified needs through the creation of client education handouts, development of diagnosis-specific Medbridge HEP templates, and creation of training resources to improve therapist efficiency with Medbridge use. Outcomes of the project included improved access to evidence-based educational materials, reduced …
Trading Precarities: How Bangladeshi Freelancers Leverage The Digital Economy Amid Local Insecurity And Ai Disruption, Naim Bin Hasan
Trading Precarities: How Bangladeshi Freelancers Leverage The Digital Economy Amid Local Insecurity And Ai Disruption, Naim Bin Hasan
Electronic Theses and Dissertations 2020 - Present
This study examines how Bangladeshi freelancers use digital platform work to cope with precarious local labor markets and how this strategy both mitigates and reproduces insecurity. In this form of work, freelancers compete for short-term, skill-based remote jobs posted by global clients. Drawing on 30 in-depth interviews and virtual ethnography, this study challenges dominant Western understandings of the precariat that assume workers fall from stable employment into insecure work. Instead, the findings show that many freelancers enter platform labor strategically as a way out of already unstable and limited local opportunities. While freelancing carries a promise of foreign income, flexibility, …
Path Planning And Control For Vertical Takeoff And Landing Aircraft, Dean Benjamin Anderson
Path Planning And Control For Vertical Takeoff And Landing Aircraft, Dean Benjamin Anderson
Theses and Dissertations
One of the challenging problems of unmanned aerial vehicles (uav) is controlling vertical takeoff and landing (vtol) aircraft. Vtol aircraft can take off and land without landing strips while retain the efficiency of fixed-wing airplanes for long range flight. Unfortunately, the transition from takeoff and forward flight, and from forward flight to landing, is an extremely difficult control problem. Most current controllers for transition switch between flight regimes based solely on airspeed. The trajectory for such switching transitions is a straight vertical ascension followed by a straight forward startup flight; it does not allow for the development of more complex …
Messages From The Provost, Georgia Southern University
Messages From The Provost, Georgia Southern University
Messages from the Provost
- Message from the Provost
- Where Care Meets Impact
- Where Students Lead
- Where Innovation Takes Flight
Electroenzymatic Cascades For Nitrogen Upgrading: Beyond Ammonia Towards Value-Added Nitrogen Chemicals, Rohit G. Jadhav, Vamshi Krishna Kamaja, Wassim El Housseini, Monica Brachi, Shelley D. Minteer
Electroenzymatic Cascades For Nitrogen Upgrading: Beyond Ammonia Towards Value-Added Nitrogen Chemicals, Rohit G. Jadhav, Vamshi Krishna Kamaja, Wassim El Housseini, Monica Brachi, Shelley D. Minteer
Chemistry Faculty Research & Creative Works
The global transition toward sustainable chemical manufacturing demands technologies that leverage natural carbon and nitrogen cycles while minimizing reliance on sacrificial reagents and fossil resources. These biogeochemical cycles are fundamental to life, and enzymes catalyze many of their key transformations. Bio electrochemical, specifically electroenzymatic, systems offer a promising route to sustainable synthesis by enabling selective redox transformations powered by electricity. However, whereas carbon-cycle enzymes are now well established in bio electrochemical synthesis, enzymes from the nitrogen cycle remain comparatively underexplored. Moreover, the nitrogen cycle alone does not access many value-added nitrogen-containing products, which require additional C-N bond formation and organic …
Quantum Scattering Of Hc5n And Para-H2 On A New Potential Energy Surface, Shan Gao, François Lique, Ernesto Quintas-Sánchez, Richard Dawes, Jérôme Loreau
Quantum Scattering Of Hc5n And Para-H2 On A New Potential Energy Surface, Shan Gao, François Lique, Ernesto Quintas-Sánchez, Richard Dawes, Jérôme Loreau
Chemistry Faculty Research & Creative Works
In the interstellar medium (ISM), non-local thermodynamic equilibrium situations are common due to low density, and one needs to consider the effect of molecular collisions in order to interpret the observations. Among the species detected in the ISM, cyanopolyynes, with the general molecular formula HC2n+1N (n = 1, 2, …), are characterized by large dipole moments and small rotational constants and constitute an indispensable class of candidates for the sensitive tracers of local density and temperature. We present a study of the collisional (de-) excitation of HC5N by para-H2 (p-H2) in its ground …
Modeling The Combined Effects Of Forest Fire And Climate Change On Snow-Water Storage In The Oregon Cascades, Joseph D. Vigil
Modeling The Combined Effects Of Forest Fire And Climate Change On Snow-Water Storage In The Oregon Cascades, Joseph D. Vigil
Dissertations and Theses
Forest fire and climate change are reshaping the snow hydrology of the Pacific Northwest of the United States, yet the combined effects of these disturbances on snow accumulation, storage, and melt timing remain poorly quantified in these Mediterranean mountain watersheds. This study integrates field-based snow and radiation observations with physically based modelling to evaluate how postfire forest structure, postfire snow albedo decay, and future climate change influence snow-water storage in the Breitenbush watershed of the western Oregon Cascades. This work was conducted as part of a broader U.S. Army Corps of Engineers effort to improve postfire hydrologic prediction and flood …
International Consensus On The Evaluation And Management Of Hypothalamic Hamartomas: Results From A Modified Delphi Survey, Nathan T Cohen, Xiaotong Li, Madison M Berl, Chima O Oluigbo, Hiroshi Shirozu, Samuel F Berkovic, Margaret Zacharin, Wirginia Maixner, Andreas Schulze-Bonhage, Kerstin Klotz, Nicola Specchio, Sarah Ferrand-Sorbets, Christine Bulteau, Alexis A Arzimanoglou, Jean Regis, J Helen Cross, Martin M Tisdall, Hanna Richardson, Arthur Cukiert, Cristine Cukiert, Julia Jacobs, Elizabeth J Donner, Phillip L Pearl, John F Kerrigan, Angus A Wilfong, Kevin C J Yuen, Dennis J Dlugos, Daniel Curry, Irfan Ali, John Ragheb, Lisa Soeby, Erica Webster, William D Gaillard
International Consensus On The Evaluation And Management Of Hypothalamic Hamartomas: Results From A Modified Delphi Survey, Nathan T Cohen, Xiaotong Li, Madison M Berl, Chima O Oluigbo, Hiroshi Shirozu, Samuel F Berkovic, Margaret Zacharin, Wirginia Maixner, Andreas Schulze-Bonhage, Kerstin Klotz, Nicola Specchio, Sarah Ferrand-Sorbets, Christine Bulteau, Alexis A Arzimanoglou, Jean Regis, J Helen Cross, Martin M Tisdall, Hanna Richardson, Arthur Cukiert, Cristine Cukiert, Julia Jacobs, Elizabeth J Donner, Phillip L Pearl, John F Kerrigan, Angus A Wilfong, Kevin C J Yuen, Dennis J Dlugos, Daniel Curry, Irfan Ali, John Ragheb, Lisa Soeby, Erica Webster, William D Gaillard
Faculty, Staff and Students Publications
Background and objectives: Hypothalamic hamartomas (HH) are rare brain lesions associated with epilepsy and numerous comorbidities. Worldwide treatment is varied. There is a paucity of high-quality evidence to guide treatment. This study aimed to establish expert consensus on the evaluation and management of HH.
Methods: A modified Delphi survey was designed by the Medical Advisory Board of Hope for Hypothalamic Hamartomas and was conducted among 17 International League Against Epilepsy level II epilepsy surgery centers. The survey included 257 questions in round 1 and 81 refined questions in round 2, covering domains of diagnosis, imaging, medical and surgical treatment, neuropsychological …
Dapk2 Regulates Pkm2 Phosphorylation At Threonine 45 To Facilitate Disturbed Flow-Induced Atherosclerosis, Shuai Guo, Long Xu, Yixin Chen, Yuan Zhao, Yuting Zhang, Runfa Yu, Kaixiang Cao, Litao Wang, Wenjia Ai, Jiang-Yun Luo, Lu Lu, Jun He, Yuan Zhou, Li Wang, Andrew H Baker, Yuqing Huo, Yiming Xu
Dapk2 Regulates Pkm2 Phosphorylation At Threonine 45 To Facilitate Disturbed Flow-Induced Atherosclerosis, Shuai Guo, Long Xu, Yixin Chen, Yuan Zhao, Yuting Zhang, Runfa Yu, Kaixiang Cao, Litao Wang, Wenjia Ai, Jiang-Yun Luo, Lu Lu, Jun He, Yuan Zhou, Li Wang, Andrew H Baker, Yuqing Huo, Yiming Xu
Faculty, Staff and Students Publications
Background: Oscillatory shear stress (OSS), resulting from disturbed blood flow, is implicated in atherosclerotic plaque formation by incompletely understood mechanisms. This study aims to elucidate the involvement of death-associated protein kinase (DAPK) 2 in OSS-induced endothelial cell (EC) activation and atherosclerosis.
Methods: Publicly available resources, including genome-wide microarray, RNA sequencing, and single-cell RNA sequencing, were utilized to identify key OSS-sensitive regulatory factors. Techniques such as mass spectrometry, immunoprecipitation, proximity ligation assay, and RNA sequencing were employed to identify pyruvate kinase M2 (PKM2) as the binding protein of DAPK2 and determine the specific site of PKM2 phosphorylation by DAPK2. To assess …
Global Impact Of Germline Structural Variation On The Cancer Proteome, Fengju Chen, Yiqun Zhang, Luis F Paulin, Darshan S Chandrashekar, Sooryanarayana Varambally, Fritz J Sedlazeck, Chad J Creighton
Global Impact Of Germline Structural Variation On The Cancer Proteome, Fengju Chen, Yiqun Zhang, Luis F Paulin, Darshan S Chandrashekar, Sooryanarayana Varambally, Fritz J Sedlazeck, Chad J Creighton
Faculty, Staff and Students Publications
Proteome and transcriptome data combined can help assess the relevance of non-coding germline variants. Here, we combine germline Structural Variants (SVs) with mass spectrometry-based proteomics on tumors from 1637 cancer patients spanning various tumor tissues of origin to determine the extent SV breakpoint patterns involve differential protein expression of nearby genes. Rare and singleton SVs disrupting protein expression of known cancer susceptibility genes collectively involve 6% of patients. About 24% of the hundreds of genes with SV-associated non-coding cis-regulatory alterations at the mRNA level are similarly associated at the protein level. Both rare and common SVs may associate with differential …