Digital Commons Network^™

Detecting Doubt In Reflective Learning: A Learning Analytics Study With Large And Small Language Models, Eng Lieh Ouh, Kar Way Tan, Siaw Ling Lo, Yuhao Zhang

Research Collection School Of Computing and Information Systems

Reflective learning enhances understanding, especially when instructors promptly address difficulties raised in student reflections. Automated doubt detection can reduce time for instructors, yet existing classification approaches take substantial time for manual annotation and model training. This paper investigates whether large and small language models (LLMs, SLMs) can automate doubt detection without time-consuming training. Using a dataset of anonymized student reflections, we evaluate zeroshot, few-shot prompting, and multi-step reasoning against prior supervised classification baselines. We show that LLMs (GPT-4o, Claude-4, Gemini-2.5) surpass earlier F1 scores without prompting, while prompting further improves their performance. However, using proprietary LLMs can raise cost and …

Gencode: A Generic Data Augmentation Framework For Boosting Deep Learning-Based Code Understanding, Zeming Dong, Qiang Hu, Xiaofei Xie, Maxime Cordy, Mike Papadakis, Yves Le Traon, Jianjun Zhao

Research Collection School Of Computing and Information Systems

Pre-trained code models lead the era of code intelligence, with multiple models designed with impressive performance. However, one important problem, data augmentation for code data that automatically helps developers prepare training data lacks study in this field. In this paper, we introduce a generic data augmentation framework, GenCode, to enhance the training of code understanding models. Simply speaking, GenCode follows a generation-and-selection paradigm to prepare useful training code data. Specifically, it employs code augmentation techniques to generate new code candidates first and then identifies important ones as the training data by influence scores. To evaluate the effectiveness of GenCode, we …

Latinos In Rural Areas Of Massachusetts, Phillip Granberry, Rodolfo R. Vega, Florita Coto Tristán, Rafael M. Pérez Medina

Gastón Institute Publications

In previous reports, the Gastón Institute has noted that the Latino population is dispersed across the state, but mainly to urban areas. In 2024, Latinos living in Massachusetts rural areas1 numbered 38,500, or 3.6% of the state's overall Latino population. Although Massachusetts is the third most densely populated among the fifty U.S. states, 52% of its land is classified as rural. These rural areas hold over 45% of the state's cities and towns and about 700,000 residents (9.9% of the total population). This report underscores the limited Latino presence in rural areas compared to urban areas and analyzes differences in …

The Quality Assurance Machine – A Software Quality Assurance Architecture For Ml-Enabled Systems, Shane E. Downing

All-Inclusive List of Electronic Theses and Dissertations

This dissertation evaluates whether a reusable assurance architecture, the Quality Assurance Machine (QAM), can provide effective product and process quality assurance for ML-enabled software platforms. The QAM is a system-level SQA architecture that turns plans and policies into versioned configurations, executes them in controlled environments, and produces preserved run evidence that supports traceability, auditability, and controlled change. The study follows Design Science Research and evaluates the instantiated artifact using eight assurance requirements (AR1–AR8) synthesized from standards-based guidance, including IEEE 730 and ISO/IEC/IEEE 15026. A four-year longitudinal evaluation combines two methods. First, operational evidence from routine regression and release-validation runs, defect …

Personality Characteristics Of Emergency Nurses And Their Subjective Fit In The Emergency Department, Jose Michael Maria

Theses & Dissertations

Nursing workforce challenges in the United States persist despite widespread recruitment and retention efforts, and the COVID-19 pandemic has further exacerbated shortages, turnover, and workforce instability. Despite interventions such as residency programs, financial incentives, and organizational initiatives, long-term retention remains inconsistent, particularly in high-demand settings like emergency departments. Ongoing issues such as overcrowding, rising patient acuity, and workforce attrition contribute to burnout, compassion fatigue, and compromised patient outcomes, perpetuating a cycle of staffing strain. Grounded in Person–Environment Fit theory, this research proposes that aligning emergency nurses’ personality traits with the specialty practice environment, the emergency department, may offer a more …

Caring For Transgender People In Healthcare: A Qualitative Descriptive Study With Nurses Working In An Acute Healthcare Setting, Gabriela Roxana Matson

Theses & Dissertations

Transgender individuals frequently encounter numerous obstacles when accessing healthcare services, including stigma, discrimination, and inadequate understanding from healthcare providers. Structural, interpersonal, and anticipation barriers significantly hinder transgender patients' access to care. Structural barriers include a lack of healthcare providers knowledgeable in transgender health and financial constraints. Interpersonal barriers involve discrimination, such as refusal to use correct pronouns or provide gender-affirming care. Anticipation barriers stem from fear of mistreatment, causing many to avoid seeking medical care altogether. Nurses play a vital role in upholding inclusive and affirming healthcare This qualitative descriptive study explored the subjective experiences of registered nurses who provided …

Bridge Building In Professional Development For Educators Working With Latinx Families: An Action Research Approach Leading To Equitable Family Engagement, Nicole Deanna Bell

Theses & Dissertations

Latinx students represent a growing population in public schools, and research highlights the importance of focusing on collectivist family engagement strategies to align with their cultural ideals. However, there is limited research on how school systems, beginning with teachers and administrators, can shift their definitions and practices to embed more collectivist-oriented strategies that foster more welcoming and inclusive spaces for Latinx families. This action-research study explored whether an asset-based lens introduced through a one-day professional development workshop could serve as a catalyst for such change. The workshop centered on participants’ storytelling, building understanding of the collectivist-individualist dichotomy, and presenting strategies …

Market Reactions To Deceptive Language In Fake News: Implications From Language Expectancy Theory And Transfer Learning, Ka Chung Ng, Ping Fan Ke, Ping Fan, Mike So, Tam, Kar Yan

Research Collection School Of Computing and Information Systems

The advent of generative artificial intelligence (AI) has heightened the proliferation of fake news. A key challenge is the limited real-world data to investigate the societal impact of fake news produced by generative AI. In this paper, we examine stock market reactions to financial news articles that exhibit stylometric similarity to human-crafted and AI-crafted fake financial news. Grounded in language expectancy theory, we employ a style-based transfer learning model, pre-trained to recognizing deceptive language employed in various types of fake news intricacies. We then apply this model to a comprehensive dataset of financial news, assigning a “veracity style score” to …

Quantitative Bounds On Resource Usage Of Probabilistic Programs, Krishnendu Chatterjee, Amir Kafshdar Goharshady, Tobias Meggendorfer, Dorde Zikelic

Research Collection School Of Computing and Information Systems

Cost analysis, also known as resource usage analysis, is the task of finding bounds on the total cost of a program and is a well-studied problem in static analysis. In this work, we consider two classical quantitative problems in cost analysis for probabilistic programs. The first problem is to find a bound on the expected total cost of the program. This is a natural measure for the resource usage of the program and can also be directly applied to average-case runtime analysis. The second problem asks for a tail bound, i.e. ‍given a threshold t the goal is to find …

Political Costs And Strategic Corporate Communication, Christine Cuny, Jungbae Kim, Mihir N. Mehta

Research Collection School Of Accountancy

When subject to public scrutiny, do firms strategically use advertising to reduce expected political costs? Advertising can ease public concerns, thereby reducing the pressure on politicians to act harshly against scrutinized firms and their industries. We use repeated congressional testimony by industry members as a novel way to identify political scrutiny. Our central finding is that scrutinized industries increase their advertising spending 132 percent more in the electorates of politicians overseeing the hearings than in the electorates of other politicians. Further, strategic advertising is complementary to income-decreasing accounting choices and a substitute for lobbying. Overall, our study sheds light on …

Cities And Climate Change, Matthias Roth, Enric Aguilar, Winston T. L. Chow

Research Collection College of Integrative Studies

We are pleased to present this special virtual collection of articles, highlighting the multifaceted interactions between cities, local climates, and global anthropogenic climate change. Climate change and urbanisation are the two global megatrends that transform human life and, at the same time, directly impact each other. Urban areas have the highest density of human populations and experience altered atmospheric conditions due to anthropogenic modification of natural physical settings and extra emissions of air pollutants and trace gases. One of the most obvious examples of climate modification due to humans is the urban heat island (UHI). This phenomenon describes urban regions, …

Spiritual Gentrification Amid The Rise Of Platform Urbanism: "Wanghong Temples" And Emerging Buddhist Cultural Economies In Tianzhu Road, Hangzhou, China, Han Zhang, Junxi Qian, Lily Kong

Research Collection School of Social Sciences

This study scrutinizes how the Tianzhu Road in the Lingyin Community - a peri-urban area in Hangzhou ringed by a cluster of temples that constitutes a distinct spiritual enclave - has been reworked through a two-phase gentrification process driven by the spiritual aesthetics and platform logics. Drawing on a two-month ethnography and media content analysis, this study conceptualizes spiritual gentrification as a spiritual aesthetics and culture-oriented recalibration of urban space in which spiritual elements operate as symbolic capital, attracting culturally motivated entrepreneurs and aligning the spiritual atmosphere with slow-life values as an alternative to urban modernity. In particular, platform urbanism …

Brief Virtual Reality And Mixed Reality Mindfulness Breathing Exercise For Emotional Well-Being And Cognitive Functions In University Students: Within-Subjects Experimental Design Study, Zoey Khai Yee Eun, Charmaine Jiali Koh, Hwajin Yang, Adalia Yin Hui Goh, Meilan Hu, K Tennakoon Appuhamillage Sandeeshwara Kasturiratna, Andree Hartanto

Research Collection School of Social Sciences

Background: Mindfulness has been shown to enhance emotional well-being and cognitive performance, yet much of this evidence stems from interventions requiring prolonged practice, making them time-consuming and less accessible. Recent studies suggest that brief mindfulness sessions may also yield positive outcomes, but the effectiveness of such interventions in virtual reality (VR) and mixed reality (MR) remains underexplored. Objective: This study investigates the effects of brief mindfulness breathing exercises delivered through VR and MR on attentional and emotional restoration and self-control capacity. Methods: Using a within-subjects experimental design, 102 undergraduate participants (n=83, 81.4% female; mean age 20.87, SD 1.89) completed a …

The Restorative Effects Of Nature Exposure Via Virtual Reality On Well-Being, Self-Control, And Working Memory, Zoey K. Y. Eun, Hwajin Yang, Nicole R. Y. Chen, Andree Hartanto

Research Collection School of Social Sciences

The psychological benefits of nature exposure are vital for well-being in an increasingly urbanised world. While previous research has consistently demonstrated the restorative effects of natural environments on both physical and psychological health, findings on virtual nature simulations remain mixed, possibly due to the limited immersive quality of conventional displays. Virtual reality (VR), however, provides immersive visual and auditory engagement, making it a promising alternative for delivering nature-based experiences when direct exposure to real nature environments is unavailable. The present study examined the effects of VR-simulated nature on attentional and emotional restoration and self-control capacity, using a preregistered, within-subjects experimental …

A Stress-Induced Digital Escapism Framework For Understanding The Link Between Stress And Problematic Social Media Use, Hwajin Yang, Frosch Yi Xuan Quek, Xiu Hui Salin Yap, Yue Qi Germaine Tng, Gilaine Rui Ng

Research Collection School of Social Sciences

Given that stress is a significant risk factor for problematic social media use, understanding the underlying psychological mechanisms is essential. We introduce the Stress-Induced Digital Escapism (SIDE) framework, which posits that negative internal emotional responses to external stressors may increase reliance on maladaptive emotion regulation strategies that fail to alleviate distress. These processes may, in turn, strengthen escapism motives that lead to seeking emotional relief through compulsive social media use. Using structural equation modeling (N = 238), we examined three integrated psychological pathways—negative stress reactions, maladaptive emotion regulation strategies, and escapism motives—as sequential mediators linking external demands to problematic social …

Research "Junkification" Is Caused By Researchers, Not Journals, Simon Sebastian Groome, Jose C. Yong, Norman P. Li

Research Collection School of Social Sciences

Concerns about declining research quality have increasingly been framed as “junkification,” whereby academic output expands in volume while declining in epistemic value. A recent paper by Rhodes and Linnenluecke (2025) attributes this trend to changes in publishing, arguing that research quality erodes as journals and publishers become increasingly oriented toward output quantity and metrics, driven by monetization. In 2009, Nobel Laureate James Watson remarked that scientific publishing in the mid-twentieth century was both easier and of a higher standard than today (Web of Stories, 2017). If publishing is much easier of late, as Rhodes and Linnenelucke (R&L) argued, then how …

Meritocracy And Equal Access To The Public Sector: A Comparative Analysis Of Accessibility To Public Sector Jobs And Public Services, Beomgeun Cho, Heasun Choi

Research Collection School of Social Sciences

This study investigates the impact of meritocracy on equal access to the public sector, focusing on public sector employment and services. While meritocratic principles promote impartiality and fairness in administrative processes, their effectiveness in improving equal accessibility remains understudied and contested. Drawing on the literature linking meritocracy to democratic stability, we argue that strong meritocratic systems enhance equal access to the public sector regardless of social groups and gender by fostering professional stewardship in the bureaucracy and strengthening checks and balances between bureaucrats and politicians. Our findings, drawn from a panel dataset consisting of 161 countries over 49 years, suggest …

Not Just Anyone: Living Situation Is Indirectly Associated With Cognitive Impairment Via Depressive Symptoms, Chin Hong Tan, Jacinth Jia Xin Tan

Research Collection School of Social Sciences

Objectives: Socially isolated individuals are at a greater risk of cognitive decline. We examined whether this relationship is dependent on the type of household living situation, living alone or living with others (spouse/ partner or relative/friend), and the indirect effects of depression. Methods: We evaluated 10,545 cognitively normal (CN, mean age = 71.6) and 9334 individuals with mild cognitive impairment (MCI, mean age = 72.9) cross-sectional data from the National Alzheimer's Coordinating Center. Participants' living situation was classified as living alone, living with spouse/partner, or living with a relative/friend. Cognitive function and depression were assessed by a neuropsychological battery and …

Miserly Thinking: Understanding The Factors Shaping Public Support Towards Project Wolbachia In Singapore, Shirley S. Ho, Agnes S. F. Chuah, Fiona J. W. Goh, Nova Mengxia Huang, Mengxue Qu, Hye Kyung Kim, Sonny Rosenthal

Research Collection College of Integrative Studies

Project Wolbachia is a vector control method that releases male Wolbachia-infected Aedes mosquitoes to curb dengue transmission in Singapore. While research has primarily focused on its efficacy, few studies have examined public opinion. This study draws upon the cognitive miser model and scientific literacy model to examine the factors shaping public support for Project Wolbachia. A nationally representative door-to-door survey was conducted in Singapore (N = 1,000) using multi-stage stratified random sampling. Our findings revealed that while knowledge about Project Wolbachia explains public support, laypeople may often rely on cognitive shortcuts, such as value predispositions, media attention, and pre-existing perceptions, …

Patterns In Awareness And Uptake Of The Lpa Among Older Adults In Singapore, Paulin Tay Straughan, Emi Loh, Shu Fang Ng, Yi Wen (Chen Yiwen) Tan, Wensi Lim

Research Collection School of Social Sciences

Findings from a survey with 7910 Singapore Life Panel members reveal that awareness of the Lasting Power of Attorney (LPA) was relatively high, but actual uptake remained low, with only one in three having made an LPA and pronounced gaps among lower socioeconomic groups. Despite this, attitudes towards LPA were generally positive, with perceived benefits centered on peace of mind and reducing burdens on family members. A major barrier to adoption is the misconception that children automatically have the legal authority to make decisions if parents lose mental capacity. Structural and psychological barriers, including cost, complexity, and limited guidance, further …

Growth Hormone Pathway As A Prognostic And Therapeutic Biomarker In Patients With Unresectable Hepatocellular Carcinoma Treated With Radiation Therapy, Joe R Eid, Safa Kaseb, Lianchun Xiao, Ryan Sun, Mahesh Kumar Kannan, Manal Hassan, Asif Rashid, Hop S Tran Cao, Hesham M Amin, Eugene J Koay

Faculty, Staff and Student Publications

Purpose: Radiation therapy (RT) has emerged as an effective local therapy option for patients with unresectable hepatocellular carcinoma (HCC) and is associated with improved overall survival (OS). However, some patients still have poor outcomes after RT, and biomarkers are needed to stratify prognostic groups. High circulating growth hormone (GH) levels promote HCC proliferation and survival and are associated with aggressive disease. In this study, we evaluated whether pretreatment GH levels are associated with OS and progression-free survival (PFS) in patients who underwent RT for unresectable HCC.

Methods and materials: Patients undergoing RT for HCC during 2017-2023 were identified from a …

The Role Of Mother Tongues In Foreign Language Acquisition: Teachers’ Perception Of Multilingual Learners, Sean Aval

Doctoral Dissertations

This qualitative study, rooted in phenomenological inquiry, explored the extent to which an understanding of language transfer informs the pedagogical decisions of foreign language teachers, most notably in how they approach the teaching of sentence construction, apply the Grammar Translation Method (GTM), and understand the errors of their foreign language students produce. The research was implemented at an Undergraduate Foreign Language School of a government-operated language institute, and drew on two complementary data sources: in-depth interviews with four experienced foreign language instructors, each of whom responded to twelve open-ended questions, and a written survey was administered to twenty-three additional foreign …

Nonmarriage? Rethinking Religious Marriage In Modern States, Shahar Lifshitz

Cardozo Law Review

This Article examines the civil regulation of religious marriage in liberal democracies. While legal scholarship has extensively explored nonmarital intimate relationships, it has paid comparatively little attention to couples who regard themselves as married under religious law without corresponding civil status, as well as couples who remain religiously married following a civil divorce. These arrangements, prevalent among religious minorities such as Orthodox Jews and Muslims, often generate significant legal and personal harms, including exclusion from civil protections, economic vulnerability, and constrained exit from intimate relationships.

This Article develops a structured analytical framework grounded in three liberal perspectives. The individual-rights perspective …

How Employment-Based Clinical Experience During Undergraduate Education Influences Transition To Practice: A Qualitative Systematic Review, Seung A. Park, Marion Eckert, Rebecca Sharp, Belinda Clark, Micah D.J. Peters

Research outputs 2022 to 2026

Aim: To synthesize qualitative evidence on the experiences of undergraduate nursing students and new graduate nurses engaged in formal paid employment models or health-related work during their undergraduate studies, to examine how these employment-based clinical experiences influence their transition to nursing practice, and to identify elements that facilitate or hinder this transition. Design: Qualitative systematic review. Methods: Searches were conducted in MEDLINE, Embase, Emcare (Ovid), CINAHL Complete (EBSCOhost), ERIC (ProQuest), and gray literature sources, including ProQuest Dissertations and Theses and Google Scholar. No date or country limits were applied, although only English-language studies were included. The review followed JBI methodology …

Growing Older Across Time And Space: The Impact Of Various Forms Of Capital On Social Support Networks Among Older Vietnamese Migrants, Hien Thi Nguyen, Lukasz Krzyzowski, Loretta Baldassar

Research outputs 2022 to 2026

Much has been written about the important role of social support networks (SSNs) for the well-being of older adults, encompassing their social, emotional and practical needs. Less is known about what happens to the SSNs of older people when they migrate, and even fewer studies have examined the impact of different forms of capital on these networks. Drawing on ethnographic interviews and participant observation with 22 older Vietnamese migrants in Australia (2020–21), this paper explores the influence of different forms of social, cultural, economic and symbolic capital on their SSNs. Data analysis comprised egocentric social network analysis of the connections …

Parenthood And Mental Health Among University Populations In Sub-Saharan Africa: A Cross-Sectional Study, Tuwani A. Rasengane, Ngozika Esther Ezinne, Antor Ndep, Nnamdi John Eseme, Susarah Maria Richter, Kingsley E. Agho, Ebele Gertrude Ejidike, Michael Agyemang Kwarteng, Kelechukwu Enyinnaya Ahaiwe, Nnaemeka Meribe, Obed Adonteng-Kissi, Edith Daniel-Nwosu, Mchillary Ogiemudia Osamudiamen, Ike Onyebuchi Oforbuike, Grace Obumneke Ogbonna, Isaura Ilorena D.Alva Brito Dos Santos, Okechi Ulumma Amaechi, Ugochukwu E. Uzuegbu, Khathutshelo Percy Mashige, Uchechukwu Levi Osuagwu

Research outputs 2022 to 2026

Background and Aims: This study examined the association between parenthood status and psychological well-being among university staff and students in sub-Saharan Africa (SSA). Methods: A cross-sectional, web-based survey was conducted across 22 universities in four SSA countries using convenience sampling. A total of 1189 university staff and students, including parents and non-parents, participated. Mental health outcomes were assessed using the Depression, Anxiety, and Stress Scales (DASS-21). Multinomial logistic regression models were used to examine associations between parenthood status and mental health outcomes after adjusting for sociodemographic and contextual factors. Results: Participants with children had lower odds of moderate depression (adjusted …

Role Of Allied Health Professions In Falls Prevention For Community-Dwelling Older Adults: A Scoping Review, Amy Lawton, Nicholas Tripodi, Rebecca Wospil, Breanna M. Wright, Hylton B. Menz, Suzanne Martin, Daniel R. Bonanno, Corey Linton, Andisheh Bastani, Andrew Ross, Rees Thomas, Daniel Corcoran, Timothy Mcnamara, Danielle Baxter, Brett Vaughan, Rebecca Lane, Jack Feehan

Research outputs 2022 to 2026

Objective: Falls among community-dwelling older adults are prevalent and have serious individual, societal and economic consequences. Allied health professionals provide key falls prevention interventions yet their representation in current clinical practice guidelines is inconsistent. Increased recognition of allied health roles and delivering context-specific guidelines for falls care could help to address workforce gaps and optimise care approaches. This scoping review explored the roles of the allied health professions in falls prevention screening, assessment and intervention for community-dwelling older adults. Design: Scoping review, using the Joanna Briggs Institute methodology for scoping reviews. Data sources: PubMed, CINAHL, Scopus, Cochrane, Web of Science …

Medical Simulation In Toxicology: Enhancing Clinical Competence, Decision Making And Patient Care In Resource-Limited Settings, Rakesh Ghimire, Anjana Thapa, Sanjeev Kharel, Shristi Kharel Ghimire, Rabin Basnet, Farshad Mazda Shirazi, Allan J. Hamilton

Research outputs 2022 to 2026

Medical simulation has emerged as a transformative approach in toxicology education. By providing immersive, hands-on experience, simulation enhances learner engagement, critical thinking, and long-term knowledge retention while offering a safe environment to practice clinical decision-making without jeopardizing patient safety. Despite these advantages, the integration of simulation-based training remains limited in low-and middle-income countries (LMICs) due to resource constraints, lack of standardized curricula, and limited access to high-fidelity simulators. Additionally, little research has explored its optimal application in these settings. This review explores available evidence regarding the effectiveness of medical simulation in the diagnosis and treatment of toxicological emergencies in LMICs. …

Gender Disparities Among General Surgeons: A Comprehensive Review, Julie Holihan, Devi Bavishi, Kush Brahmbhatt, Rebecca Franks, Zuhair Ali, Karla Bernardi, Christine Castillo, Mike Liang, Rachel Wong, Michele Loor

Faculty, Staff and Student Publications

Background: Unlike in-house call, the Accreditation Council for Graduate Medical Education (ACGME) does not require a postcall day for "home call" shifts. Despite this, we hypothesize that on-call residents are still in the hospital for the majority of their shift despite having the luxury of home call and, thus, are not protected by ACGME postcall duty hour regulations.

Methods: A prospective single center survey study was conducted by surveying junior and senior residents who completed overnight call shifts from January 2023 to April 2023 at one of the busiest level 1 trauma centers in the United States. Data include number …

Psychotropic Medications And Their Interactions With Subcortical Brain Volume In Bipolar Disorder: An Enigma Mega-Analysis, Sinead King, John O'Connor, Emma Corley, Giulia Tronchin, Elisa Fontana, Leila Nabulsi, Melody J Y Kang, Joaquim Radua, Brian Hallahan, Christoph Abé, Martin Alda, Dag Alnæs, Silvia Alonso-Lana, Silvia Amoretti, Jochen Bauer, Francesco Benedetti, Klaus Berger, Michael Berk, Erlend Bøen, Joscha Böhnlein, Birgitte Boye, Beatrice Bravi, Erick J Canales-Rodríguez, Udo Dannlowski, Caroline Demro, Annabella Di Giorgio, Ana M Diaz-Zuluaga, Torbjørn Elvsåshagen, Pauline Favre, Tracy Erwin-Grabner, María Florencia Forte, Janice M Fullerton, Lisa S Furlong, Susan L Rossell, David C Glahn, Benjamin I Goldstein, Ian H Gotlib, Roberto Goya-Maldonado, Melissa J Green, Dominik Grotegerd, Oliver Gruber, Bartholomeus C M Haarman, Tim Hahn, Tomas Hajek, Leonie Hater, Marco Hermesdorf, Josselin Houenou, Fleur M Howells, James A Karantonis, Kody G Kennedy, Tilo Kircher, Anna Luisa Klahn, Maximilian Konowski, Bernd Krämer, Elijah Lahud, Rayus Kuplicki, Mikael Landén, Carlos López-Jaramillo, Bradley J Macintosh, Hannah Meinert, Susanne Meinert, Elisa M T Melloni, Philip B Mitchell, Benson Mwangi, Igor Nenadić, Bronwyn J Overs, Nadine Parker, Godfrey Pearlson, Edith Pomarol-Clotet, James J Prisciandaro, Yann Quidé, Gloria Roberts, Amanda Rodrigue, Elena Rodríguez-Cano, Lisa Rauer, Matthew D Sacchet, Raymond Salvador, Fabio Sambataro, Theodore D Satterthwaite, Jonathan Savitz, Freda Scheffler, Navid Schürmeyer, Chen Shen, Kang Sim, Jair C Soares, Aleix Solanes, Márcio Gerhardt Soeiro-De-Souza, Scott R Sponheim, Dan J Stein, Frederike Stein, Henk S Temmingh, Lea Teutenberg, Sophia I Thomopoulos, Snezana Urosevic, Tamsyn E Van Rheenen, Eduard Vieta, Lars T Westlye, Daniel H Wolf, Mon-Ju Wu, Lakshmi N Yatham, Giovana B Zunta-Soares, Dara M Cannon, Paul M Thompson, Ole A Andreassen, Christopher R K Ching, Colm Mcdonald

Faculty, Staff and Student Publications

MRI studies in bipolar disorder (BD) have yielded inconsistent findings, partly due to the varied use of psychotropic medications. This study utilised a mega-analysis approach, accounting for concurrent medication status (syndrome-based and Neuroscience-based Nomenclature (NbN) classifications), in order to assess the association of medication status with subcortical brain volumes in BD. Data from 2,664 BD patients and 4,065 controls (CN) were pooled from 34 research groups as part of the ENIGMA Bipolar Disorder Working Group. Standardized ENIGMA protocols were used to measure subcortical brain volumes. Linear-mixed-effects regression evaluated the association between psychotropic medications and subcortical volumes, and moderation analyses explored …