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Articles 11311 - 11340 of 1439315
Full-Text Articles in Entire DC Network
Survey Of Medieval Literature On Maternal Mortality, Postpartum Care, And Birth Trauma In Relation To The Crisis In Arkansas, Paige Q. Thompson
Survey Of Medieval Literature On Maternal Mortality, Postpartum Care, And Birth Trauma In Relation To The Crisis In Arkansas, Paige Q. Thompson
English Undergraduate Honors Theses
When the general public thinks of childbirth in the Middle Ages, they think of death and danger. However, Arkansas has the highest maternal mortality rate in the entire United States, and many of those deaths are preventable. There have been previous analyses on different medieval texts as well as research into modern Arkansas, but none have made a direct connection between the two subjects. By analyzing medieval literature to understand cultural norms surrounding childbirth and postpartum care, patterns can be traced to modern Arkansas, where needless deaths are still prevalent. Ultimately, medieval texts demonstrate cultural attitudes surrounding blame toward women …
Addressing Low Vaccination Rates In Lewis County, New York: A Community-Based Participatory Research Study, Samantha Carter
Addressing Low Vaccination Rates In Lewis County, New York: A Community-Based Participatory Research Study, Samantha Carter
Anthropology
Low rates of on-time human papillomavirus (HPV) vaccination continue to remain a significant public health concern, particularly in rural communities, one being Lewis County NY, which reports the lowest rate of vaccination in the state. This study, through Upstate Medical University, uses a Community-Based Participatory Research (CBPR) model in efforts to examine barriers to HPV vaccination and identifying community-driven solutions formulated by committee members from within the community. A steering committee composed of researchers and community members, who were also co-researchers, worked collaboratively to develop and distribute surveys to healthcare providers, dentists, and parents. Responses revealed that while many parents …
Integrating Doulas Into The Medical Team, Alyssa Shaw
Integrating Doulas Into The Medical Team, Alyssa Shaw
Anthropology
This thesis explores the potential integration of doulas into the obstetric medical team, defining birth as a cultural and social experience as well as a physiological process. Drawing on anthropological literature and historical accounts, I examine the shift from social, woman-centered childbirth practices to the medicalized model that occurs in modern American obstetrics. While this transformation has improved maternal and infant mortality rates, it has also caused a loss of continuous emotional and social support for laboring mothers, as well as a shift in autonomy from the birthing person to medical professionals. To investigate how doulas may help bridge this …
Microplastics And Generational Harm, Sara Najafi
Microplastics And Generational Harm, Sara Najafi
Anthropology
Microplastics are persistent environmental contaminants increasingly detected in ecosystems and the human body, raising concerns about their effects on health and future generations. This paper examines the environmental pathways, biological mechanisms, and reproductive consequences of microplastic exposure, with particular attention to female reproductive health and fetal development. Current evidence indicates that microplastics can contribute to oxidative stress, inflammation, endocrine disruption, DNA damage, and cellular dysfunction, while also accumulating in reproductive tissues, follicular fluid, placental tissue, and breast milk. These exposures may impair ovarian function, fetal development, and long-term health outcomes. The paper also considers environmental inequalities that may increase exposure …
Bound To Status: A Comparative Study Of Public And Private College Libraries, Lilianna Fujita
Bound To Status: A Comparative Study Of Public And Private College Libraries, Lilianna Fujita
Anthropology
This ethnographic study compares student culture and behavior at two upstate New York universities — Rensselaer Polytechnic Institute (RPI), a private STEM-focused institution, and the University at Albany (UAlbany), a public research university. Through two rounds of participant observation conducted in each school's library and three semi-structured student interviews, the author examines how institutional type, admissions selectivity, campus environment, and resource allocation shape student social dynamics, gender experiences, and overall well-being. The author argues that differences in student behavior reflect not only individual student dispositions but broader institutional decisions about who is admitted and what social infrastructure is supported.
Design Of An Extensible And Scalable Data Acquisition System For Pulse Shape Discrimination, Prince John
Design Of An Extensible And Scalable Data Acquisition System For Pulse Shape Discrimination, Prince John
McKelvey School of Engineering Graduate Student Theses & Dissertations
This thesis presents the design and development of a highly scalable, end-to-end data acquisition (DAQ) system for nuclear physics experiments that can be deployed in configurations ranging from a few to thousands of detector channels. The system is built as an extensible platform composed of modular 16-channel chipboards that support a wide range of scintillator and detector types and perform real-time, on-board data sparsification and pulse-shape processing. Three versions of the chipboard have been fabricated to date.
The DAQ architecture is based on a family of analog pulse-shape-processing application- specific integrated circuits (ASICs) developed by the IC Design Laboratory at …
Conditioning Hierarchical Diffusion Transformers On Rf Circuit Parameters, Ethan Morton
Conditioning Hierarchical Diffusion Transformers On Rf Circuit Parameters, Ethan Morton
McKelvey School of Engineering Graduate Student Theses & Dissertations
As modern ML techniques have become increasingly advanced, they have begun to be integrated into wireless RF systems for classification, identification, and spectrum management. Deep Neural Networks (DNNs) enable RF system operators and designers to design more flexible systems with greater robustness to errors and attacks. However, neural networks require significant amounts of properly annotated data to train. Current data labeling methods lack the ability to obtain reliable true labels for circuit properties such as carrier frequency offset (CFO), power amplifier (PA) non-linearity, and in-phase/quadrature (IQ) imbalance. This thesis investigates the efficacy of a novel architecture, RF-Diffusion, for generating high-quality …
Temporal Logic Planning In Semantic Maps Of Unknown Environments Using Tl-Rrt, Dongrui Yang
Temporal Logic Planning In Semantic Maps Of Unknown Environments Using Tl-Rrt, Dongrui Yang
McKelvey School of Engineering Graduate Student Theses & Dissertations
Autonomous mobile robots are increasingly expected to perform complex missions in unstructured environments. Traditional path planning approaches handle simple point-to-point navigation, but struggle with complex tasks that involve temporal and logical orderings of objectives. Linear Temporal Logic (LTL) provides a method for complex missions (e.g., sequential visits to multiple targets or surveillance tasks) in a strict way. This thesis presents an integrated planning framework that enables a robot to satisfy LTL-based task specifications in an unknown environment by combining a Temporal Logic RRT* (TL-RRT*) planner with semantic mapping. The robot builds a semantic map of its environment online using simultaneous …
The Social Seam: Combating Social Isolation Through Architecture, Elissa Hammrich
The Social Seam: Combating Social Isolation Through Architecture, Elissa Hammrich
Architecture Theses
A lack of walkable environments and well-supported public spaces has created a crisis of social disconnection across the United States. Historically, dating back to the public squares of ancient Greece, the public realm was a place of communal ritual from which citizens drew their primary identity. Today, however, modern cities are driven by commerce and technology, rapidly losing the genuine spaces that create face-to-face human interaction. By prioritizing the efficient movement of vehicles and goods over human connection, it has left behind fractured, isolated communities.
This thesis explores architectural strategies to combat this social isolation, focusing specifically on the Near …
Nature And Nurture: The Cognitive Image Of A Building And Its Site, Treyton Hardy
Nature And Nurture: The Cognitive Image Of A Building And Its Site, Treyton Hardy
Architecture Theses
Current specialized care facilities often prioritize functionality over the emotional and psychological well-being of their residents. For individuals experiencing dementia, illegible architectural layouts hinder spatial problem-solving and cause severe disorientation. This thesis introduces "Nature & Nurture," a comprehensive dementia recovery and research community proposed for Duluth, Minnesota. By utilizing Kevin Lynch’s Five Elements of the cognitive image, this project establishes an evidence-based architectural framework designed to reduce cognitive load. The design integrates multi-sensory wayfinding cues, continuous circulation paths, and hyper-local landmarks to facilitate environmental recognition rather than demanding complex memory recall. Ultimately, this thesis demonstrates how legible spatial design can …
Advancements In Wall Systems For Cold Climate Timber Frame Structures, Albert Gérard
Advancements In Wall Systems For Cold Climate Timber Frame Structures, Albert Gérard
Architecture Theses
Timber frame buildings hold a privileged place in the homebuilding industry, where they are prized as a uniquely desirable construction method. Commonly cited reasons for their appeal are the way they feature natural materials and the prominent use of solid wood joinery. Although construction methods for the structures themselves were established through a series of seminal 1980s and 1990s English-language publications, the lack of a suitable wall system has continued to present challenges to achieving more widespread adoption.
A Translation Of Culture, Dinithi Warnakula
A Translation Of Culture, Dinithi Warnakula
Architecture Theses
This thesis explores the processes of shared occupation, layering and translation in architecture as a means of cultural cohabitation. Located on the Keating Channel waterfront in Toronto, the project explores themes of migration, shifting identities and communal life in an urban context. The thesis, beginning with the theories of Vilém Flusser and Daniel Heller-Roazen, addresses translation as linguistic and geographical condition. The layered Sinhala, Tamil and English characters produce an artefact that throws dynamic shadows that interact with the physical architecture through tiered thresholds, framed views and filtered light conditions. This created cultural commons, spaces for everyday interaction, narration, socialisation …
The Phenomenology Of Home: Exploring The Interlinked Relationships Between Dwelling And Domestic Architecture, George Martin Grunklee
The Phenomenology Of Home: Exploring The Interlinked Relationships Between Dwelling And Domestic Architecture, George Martin Grunklee
Architecture Theses
This thesis explores the concept of home from a phenomenological perspective to inform a communication method and design process for domestic architecture. While “home” holds multiple meanings, this study traces the phenomenological relation between human’s embedded existence and place—to understand home as a condition shaped by the lived experiences of its inhabitants. The aim of this thesis is to understand how the design of domestic architecture is intrinsically linked to dwelling and to the accumulation of lived experiences.
The thesis critically engages phenomenology in architectural practice by exploring case studies which exhibit and foster the concept of home. Frank Lloyd …
Little Wonders: Designing Childcare Facilities That Facilitate Cognitive Development Inspired By Reggio Emilia And Montessori Pedagogies, Makayla Parkin
Little Wonders: Designing Childcare Facilities That Facilitate Cognitive Development Inspired By Reggio Emilia And Montessori Pedagogies, Makayla Parkin
Architecture Theses
This thesis challenges traditional childcare facility design strategies and studies and develops design principles that facilitate and support children’s cognitive development. By understanding how children learn through cognitive and neuroarchitecture research, this thesis targets cognitive milestones within each age range of children to best support their early childhood developmental needs. This proposed childcare facility design will incorporate children’s learning needs, large motor function developmental needs, sensory exploration, interactive design, proximity to nature, and childcare licensing requirements to produce a quality and effective design.
Located in Shakopee, Minnesota this project addresses underserved and growing communities in need of childcare. Therefore, this …
Prairie Haven: Combating Urban Sprawl With Ecological Landscape Assemblage In Forest Lake, Minnesota, Ryan Anthony Calhoun
Prairie Haven: Combating Urban Sprawl With Ecological Landscape Assemblage In Forest Lake, Minnesota, Ryan Anthony Calhoun
Landscape Architecture Theses
Contemporary residential developments frequently default to sprawl, creating fragmented environments that lack both environmental resilience and authentic human interconnection. This thesis explores how landscape architects can utilize Assemblage Theory to design residential developments where sustainable materials, ecological systems, and social elements dynamically assemble to create a meaningful, human-scaled sense-of-place. By synthesizing the structural planning efficiency of New Urbanism, the ecological imperatives of Landscape Urbanism, and the metrics-driven performance of Ecological Urbanism, this research develops a hybridized operational approach to residential development. Applied to a master plan in Forest Lake, Minnesota, the design for “Prairie Haven” demonstrates how treating a neighborhood …
Living Shorelines: A Regenerative Landscape Approach To Coastal Protection And Community Resilience In Bhasan Char, Bangladesh, Anamul Hoque Mojumder
Living Shorelines: A Regenerative Landscape Approach To Coastal Protection And Community Resilience In Bhasan Char, Bangladesh, Anamul Hoque Mojumder
Landscape Architecture Theses
Bhasan Char is a newly formed, unstable silt island in Bangladesh which is home for more than one million Rohingya refugees—an ethnic Muslim minority from Myanmar who have fled decades of systematic persecution and violence—suffering from an ecological and humanitarian crisis. This community faces extreme vulnerability from cyclones and sea-level rise on a landscape of profound precarity.
Traditional hard-engineered defenses are costly, ecologically damaging, and ineffective against the island’s dynamic geomorphology. This research proposes a regenerative "Living Shorelines" model, intersecting coastal resilience with refugee empowerment through Blue-Green Infrastructure. Drawing on successful global precedents in Vietnam and the USA, the study …
Fields Of Home: Dignified Housing Design For Migrant Farmworkers In Rural North Dakota And Rural Minnesota, Kenady Slominski
Fields Of Home: Dignified Housing Design For Migrant Farmworkers In Rural North Dakota And Rural Minnesota, Kenady Slominski
Architecture Theses
Migrant agricultural workers are often faced with challenges regarding their housing. These housing conditions lack privacy, permanence, and a connection to the community. Existing solutions tend to prioritize efficiency and cost over the emotional, social, and cultural needs of residents. Therefore, the existing solutions are unable to create a sense of dignity. Additionally, there is limited regional research addressing migrant worker housing conditions in Minnesota and North Dakota specifically.
This project explores how architectural design can improve living conditions through a focus on dignity and community integration. The proposed development consists of duplex homes in one- and two-bedroom units with …
Erasing Boundaries: Strategies For Universities And Cities In Developing Integrated Planning, Jack Quinn
Erasing Boundaries: Strategies For Universities And Cities In Developing Integrated Planning, Jack Quinn
Architecture Theses
The population of the Fargo-Moorhead area is steadily growing per year, however since 2010 both Concordia and Minnesota State University Moorhead have seen a steady decrease in students. Factors such as President Trump’s immigration policies, lower birth rates, and high school students who are doubting the value of a college education has set the stage for a difficult future for universities in the United States of America. This thesis will explore Town-Gown relations, studentification, and the strategies behind the best designed campuses in America. It will explore the relationship between neighboring schools, P3 developments, dive into what the Metro college …
Re-Barn: Adaptive Barn Reuse As A Model For Aging In Place And Multigenerational Living On A Rural North Dakota Farmstead, Jared Eggermont
Re-Barn: Adaptive Barn Reuse As A Model For Aging In Place And Multigenerational Living On A Rural North Dakota Farmstead, Jared Eggermont
Architecture Theses
Across rural landscapes, agricultural buildings are increasingly left vacant as farming practices evolve, while a growing senior population remains in homes ill-equipped to support aging, often facing challenges with daily needs, health, and social connection as younger generations leave for urban areas. These underutilized farmsteads present an opportunity to support multigenerational living through the reuse of existing structures, allowing families to remain rooted while adapting to changing needs. This thesis explores how rethinking agricultural buildings can sustain social and physical continuity, drawing on research into adaptive reuse, aging in place, multigenerational households, and rural living. It proposes design strategies on …
Building On Memory: Towards A Digital Future Informed By Historical Theory, Lucas Laskow
Building On Memory: Towards A Digital Future Informed By Historical Theory, Lucas Laskow
Architecture Theses
This project synthesizes 2,000 years of architectural theory to establish an ethical framework for integrating artificial intelligence into contemporary design. The research culminates in “The Chandler,” demonstrating how AI can enhance, rather than replace, human-driven spatial and cultural values.
The assertion that human design is inherently superior to artificial intelligence relies on the flawed premise that intuitive leaps outweigh data-driven synthesis. Rather than diminishing the architect’s role, the evolution of AI demands that designers become ethical interpreters who ask the right questions. This project investigates how past architectural theorists, from Vitruvius’s foundational triad to Bruce Allsopp’s humanist return, provide a …
Illinois State University, One Hundred And Sixty-Seventh Annual Commencement, May 2026, Illinois State Universtiy
Illinois State University, One Hundred And Sixty-Seventh Annual Commencement, May 2026, Illinois State Universtiy
Commencement Programs
Illinois State University
One Hundred and Sixty-Seventh Annual Commencement
May 2026
Multidisciplinary Approach To Complex Lower Extremity Limb Salvage In Pyogenic Arthritis, Pyoderma Gangrenosum, And Acne (Papa) Syndrome: A Case Report, Michael M Talanker, Anthony V Basta, Tien Do, Robert Tung, Addison Allen, Morgan Martin, Bryan L Ruygrok, Patrick J Kellam, Jeffrey G Trost, Mohin A Bhadkamkar
Multidisciplinary Approach To Complex Lower Extremity Limb Salvage In Pyogenic Arthritis, Pyoderma Gangrenosum, And Acne (Papa) Syndrome: A Case Report, Michael M Talanker, Anthony V Basta, Tien Do, Robert Tung, Addison Allen, Morgan Martin, Bryan L Ruygrok, Patrick J Kellam, Jeffrey G Trost, Mohin A Bhadkamkar
Faculty, Staff and Student Publications
Limb salvage using free tissue transfer in patients with rare autoinflammatory syndromes is poorly described, and the safety of microvascular reconstruction in this population remains uncertain. Hereditary pyogenic arthritis, pyoderma gangrenosum, and acne (PAPA) syndrome is characterized by dysregulated inflammation, pathergy, and impaired wound healing, raising concern for flap compromise and postoperative complications. We report a rare case of lower extremity free tissue transfer in a patient with PAPA syndrome. A 66-year-old woman with rheumatoid arthritis and PAPA syndrome presented with rapid wound breakdown, violaceous ulceration, exposed hardware, and periprosthetic joint infection following left total knee arthroplasty (TKA). Examination revealed …
Severe, Non-Apneic Respiratory Dysfunction And Hypoxia Following Generalized Convulsive Seizures, Haley E Pysick, Rup K Sainju, Roshni Nair, Deidre N Dragon, Eduardo Bravo, Laura Vilella, Xiaojin Li, Samden D Lhatoo, George B Richerson, Brian K Gehlbach
Severe, Non-Apneic Respiratory Dysfunction And Hypoxia Following Generalized Convulsive Seizures, Haley E Pysick, Rup K Sainju, Roshni Nair, Deidre N Dragon, Eduardo Bravo, Laura Vilella, Xiaojin Li, Samden D Lhatoo, George B Richerson, Brian K Gehlbach
Faculty, Staff and Student Publications
Objective: Sudden unexpected death in epilepsy (SUDEP) is a devastating consequence of some generalized convulsive seizures (GCS). Recent work has focused on seizure related apnea as a biomarker of SUDEP risk, frequently without characterizing the adequacy of non-apneic ventilation or identifying other dysfunctional breathing patterns. We hypothesized that GCS frequently induce immediate, severe, non-apneic respiratory dysfunction that can induce critical hypoxia and bradycardia and sought to characterize breathing patterns after GCS.
Methods: Adult patients admitted to an epilepsy monitoring unit were studied. The effects of GCS on breathing and heart rate were analyzed using nasal pressure transducers, chest and abdominal …
Assessment Of Skin In Patients With Systemic Sclerosis Using High-Frequency Ultrasound And Shear Wave Elastography: A Comparative Study With Histology, Molecular, And Clinical Parameters, Ruhani Desai, Filemon Tan, Minghua Wu, Jeffery L Browning, Samuel Theodore, Meng Zhang, Brian Skaug, Harshdeep Singh Chawla, Manmohan Singh, Salavat Aglyamov, Kirill V Larin, Maureen Mayes, Shervin Assassi
Assessment Of Skin In Patients With Systemic Sclerosis Using High-Frequency Ultrasound And Shear Wave Elastography: A Comparative Study With Histology, Molecular, And Clinical Parameters, Ruhani Desai, Filemon Tan, Minghua Wu, Jeffery L Browning, Samuel Theodore, Meng Zhang, Brian Skaug, Harshdeep Singh Chawla, Manmohan Singh, Salavat Aglyamov, Kirill V Larin, Maureen Mayes, Shervin Assassi
Faculty, Staff and Student Publications
Objective: Ultrasound (US) has been proposed as a potential tool for assessing skin fibrosis in systemic sclerosis (SSc). However, a large-scale comparison of US-based assessment with histologic markers of skin fibrosis has not been reported. We evaluated US-based skin assessments for their face validity (differentiation between involved SSc and healthy control [HC] skin), construct validity (comparison to modified Rodnan skin score [mRSS]), and criterion validity (comparison to histologic and gene expression fibrosis markers).
Methods: Twenty HCs and 52 patients with SSc underwent clinical and US assessment followed by a forearm skin biopsy. Predefined areas were assessed on the finger, hand, …
Brief Report: Hepatitis B Vaccination Histories In Persons With Hiv Needing Revaccination, Minhee Kang, Triin Umbleja, Anchalee Avihingsanon, Sandra W Cardoso, Josphat Kosgei, Karen J Vigil, Ta Thi Dieu Ngan, Unoda Chakalisa, Stephanie Caruso, Kenneth E Sherman, Kristen M Marks
Brief Report: Hepatitis B Vaccination Histories In Persons With Hiv Needing Revaccination, Minhee Kang, Triin Umbleja, Anchalee Avihingsanon, Sandra W Cardoso, Josphat Kosgei, Karen J Vigil, Ta Thi Dieu Ngan, Unoda Chakalisa, Stephanie Caruso, Kenneth E Sherman, Kristen M Marks
Faculty, Staff and Student Publications
Introduction: Past studies of hepatitis B vaccines in people with HIV (PWH) have shown mixed results about improving responses with increases in dose or dose frequency, leading to inconsistent guidelines and practice. We examined vaccine series completion and revaccinations in PWH lacking a seroprotective response.
Methods: Hepatitis B vaccination histories were evaluated as a retrospective study in 561 participants of A5379 trial (NCT04193189). Individuals in 41 sites in Africa, Asia, South America, and the United States qualified for the trial with antibody titers below the seroprotective level (< 10 mIU/mL) despite past hepatitis B vaccinations. The primary measure of interest was the number of vaccines in the past vaccination records.
Results: Of the 1098 trial candidates, 561 (51%) did not …
Quantitative Muscle Magnetic Resonance Imaging Demonstrates Resolution Of Muscle Edema In Refractory Dermatomyositis: A Post Hoc Analysis Of A Proof-Of-Concept Clinical Trial Of Tofacitinib, Mona Dabiri, Anshula Nallapati, Marwin Groener, Patrick Debs, Jemima Albayda, Eleni Tiniakou, Lisa Christopher-Stine, Laura Fayad, Julie J Paik
Quantitative Muscle Magnetic Resonance Imaging Demonstrates Resolution Of Muscle Edema In Refractory Dermatomyositis: A Post Hoc Analysis Of A Proof-Of-Concept Clinical Trial Of Tofacitinib, Mona Dabiri, Anshula Nallapati, Marwin Groener, Patrick Debs, Jemima Albayda, Eleni Tiniakou, Lisa Christopher-Stine, Laura Fayad, Julie J Paik
Faculty, Staff and Student Publications
Objective: To evaluate changes in muscle edema using short-tau inversion recovery (STIR) imaging and quantitative diffusion-weighted imaging (DWI) with apparent diffusion coefficient (ADC) mapping in patients with refractory dermatomyositis (DM) treated with tofacitinib.
Methods: This post hoc imaging analysis included patients from a 12-week, open-label trial of tofacitinib 11 mg daily in refractory DM. Bilateral thigh magnetic resonance imaging was obtained at baseline and week 12 using standardized STIR, T1-weighted, and DWI sequences. Muscle edema (ME) and fascial edema were assessed qualitatively on STIR imaging. ADC values were measured in muscles demonstrating baseline STIR hyperintensity using three nonoverlapping regions of …
Race To Mitigate Aortic Dissection: Exercise, Pde5a, And The Dissecting Aorta, Siddharth K Prakash
Race To Mitigate Aortic Dissection: Exercise, Pde5a, And The Dissecting Aorta, Siddharth K Prakash
Faculty, Staff and Student Publications
No abstract provided.
The Impact Of Rapid Infusers On The Hemostatic Potential Of Cryoprecipitate Products, Connor D Purvis, Samantha Redden, Andrew Jacobson, Yao-Wei Wang, Julie Campbell, Jessica Cardenas, Jan-Michael Van Gent, Bryan A Cotton
The Impact Of Rapid Infusers On The Hemostatic Potential Of Cryoprecipitate Products, Connor D Purvis, Samantha Redden, Andrew Jacobson, Yao-Wei Wang, Julie Campbell, Jessica Cardenas, Jan-Michael Van Gent, Bryan A Cotton
Faculty, Staff and Student Publications
Background: In cases of massive transfusion, intravenous access can be limited. Additionally, delivering different products through separate lines and infusion methods adds unnecessary steps. RBC, plasma, and whole blood (WB) are delivered via rapid infusers; cryoprecipitate (CRYO) is infused through separate access and is not approved with these devices.
Study design and methods: We examined the impact of different transfusion methods on hemostatic performance and factor activity using two available CRYO products. Ten bags of CRYO, ten bags pathogen-reduced CRYO (Intercept® Fibrinogen Complex, IFC), and 20 units of WB were obtained. Each CRYO bag was infused with one unit of …
Estrogen As A Therapeutic Agent: Targeting Endotheliopathy And Coagulopathy In Trauma, Niruktha Raghavan, Mira Patel, Bryan A Cotton, Julia Coleman, Donald Jenkins
Estrogen As A Therapeutic Agent: Targeting Endotheliopathy And Coagulopathy In Trauma, Niruktha Raghavan, Mira Patel, Bryan A Cotton, Julia Coleman, Donald Jenkins
Faculty, Staff and Student Publications
Background: Traumatic injury remains a leading cause of death, often due to uncontrolled hemorrhage and trauma-induced coagulopathy (TIC). TIC is critically triggered by the endotheliopathy of trauma, involving endothelial cell injury and glycocalyx degradation. Despite conventional advances, the stable casualty rate underscores the urgent need for new precision resuscitation strategies that acknowledge factors like biological sex.
Design: The central hypothesis is that estrogen confers a survival advantage in hormonally active females through a dual action: endothelial cell stabilization (halting glycocalyx shedding) and its inherent procoagulant effect. The analysis assesses the therapeutic potential of both exogenous estrogen and female-derived blood products …
Declaring Futility After Traumatic Injury And The Burden Of Failure On The Surgeon, Jan-Michael Van Gent, Bryan A Cotton
Declaring Futility After Traumatic Injury And The Burden Of Failure On The Surgeon, Jan-Michael Van Gent, Bryan A Cotton
Faculty, Staff and Student Publications
In this edition of the THOR supplement in Transfusion, there are two articles that deal with resuscitation futility and transfusion. In one article, Yazer et al. delve into the details of the studies outlined in this editorial and summarize the literature on the topic of transfusion and futility. The second article by Dr. Jay Malone discusses the ethical issues surrounding massive transfusion and resuscitation. Taken together, these articles address the clinical and ethical issues surrounding this very emotive and difficult topic.