Digital Commons Network^™

A Novel Treponema Pallidum Subspecies Pallidum Strain Associated With A Painful Oral Lesion Is A Member Of A Potentially Emerging Nichols-Related Subgroup, Maria Rosa Velasquez, Bridget D De Lay, Diane G Edmondson, Gary P Wormser, Steven J Norris, Kaitlin Cafferky, Eric Munzer, Ciril-Christian Rizk, Marina Keller

Faculty, Staff and Student Publications

Background: Early syphilitic lesions are typically painless; however, several recent case studies have included patients with tender lesions and no evidence of concurrent infections. Here we present the manifestations and serological and molecular findings of a patient from New York State with a painful tongue lesion.

Methods: The diagnosis of syphilis was based on a combination of physical examination, serologic, pathologic, and immunohistochemical findings. DNA obtained from a formalin-fixed, paraffin-embedded biopsy was used to characterize the infecting pathogen using polymerase chain reaction, multilocus sequence typing, and whole-genome sequencing methods.

Results: Polymerase chain reaction and multilocus sequence typing of the biopsy …

Hepatitis B Reactivation And Liver Failure Because Of Covid-19 Infection, Muhammad Mushtaq, Keegan Colletier, Akshata Moghe

Faculty, Staff and Student Publications

Coronavirus disease 2019 (COVID-19) has been associated with liver injury incidence reported between 15% and 53%. Viral binding to ACE2 receptors in hepatobiliary cells is believed to cause liver inflammation. The relationship between hepatitis B and COVID-19 is poorly understood, but patients treated with immunosuppressive therapy for COVID-19 are at higher risk of hepatitis B reactivation (HBVr). We present a case of a patient with HBVr because of COVID-19, in the absence of any immunosuppressive treatment, leading to fulminant liver failure and subsequent requiring liver transplantation. Given low incidence, limited data, and no current guidelines, further studies are needed to …

Impact Of Antiretroviral Therapy During Acute Or Early Hiv Infection On Virologic And Immunologic Outcomes: Results From A Multinational Clinical Trial, Trevor A Crowell, Justin Ritz, Lu Zheng, Asma Naqvi, Joshua C Cyktor, Joseph Puleo, Brian Clagett, Javier R Lama, Cecilia Kanyama, Susan J Little, Susan E Cohn, Sharon A Riddler, Ann C Collier, Sonya L Heath, Pornphen Tantivitayakul, Beatriz Grinsztejn, Roberto C Arduino, James F Rooney, Gert U Van Zyl, Robert W Coombs, Lawrence Fox, Jintanat Ananworanich, Joseph J Eron, Scott F Sieg, John W Mellors, Eric S Daar

Faculty, Staff and Student Publications

Objective: To assess how antiretroviral therapy (ART) initiation during acute or early HIV infection (AEHI) affects the viral reservoir and host immune responses.

Design: Single-arm trial of ART initiation during AEHI at 30 sites in the Americas, Africa, and Asia.

Methods: HIV DNA was measured at week 48 of ART in 5 million CD4 + T cells by sensitive qPCR assays targeting HIV gag and pol . Peripheral blood mononuclear cells were stimulated with potential HIV T cell epitope peptide pools consisting of env , gag , nef, and pol peptides and stained for expression of CD3, CD4, CD8, and …

University Of San Diego Magazine 75th Anniversary 2024, University Of San Diego

University of San Diego Magazine (1992- )

Forging Community; Celebrating Impact; Aesthetic Aspirations; From Grassroots to the Vatican; Lighting the Way Forward; Decade of Discovery; The Stories Within; Those at Our Core; Aiming for Excellence; Twice as Nice; A Simple Yet Grand Vision

Croning Academics: Menopause Matters In Higher Education, Marie Lavelle, Joanna Haynes, Emma Macleod-Johnstone

School of Law, Humanities and Social Sciences

This writing is born out of our experiences of becoming older women, academy hags, facing the performative demands of the neoliberalising patriarchal university. We are raging. With the figure of the Crone, and feminist-killjoy-croning as our creative and livid research method (Ahmed, 2023), we squeeze time out/with impossible university spaces and schedules to tend to grey matters. The paper traces the normalisation of menopause policies in workplaces and universities, following the social trending and capitalisation of menopausal and ageing matters. We question what menopause policies do and argue they constitute a failed project for the advancement of gender equality and …

2024 July, Morehead State University. Office Of Communications & Marketing.

Morehead State Press Release Archive, 1961 to the Present

Press releases for July of 2024.

Exploring The Mutual Benefits Of Reciprocal Mentorship In A Community-Based Program: Fostering Community Cultural Wealth Of Latino Students And Families, Elizabeth Gil, Ceceilia Parnther

GSE Faculty Publications

This case study examines reciprocal mentoring in a community-based program (CBP) serving immigrant Latino families with school-aged children. University student volunteers shared technological and college knowledge and grew in leadership skills. Simultaneously, they gained familial and cultural support and belonging from program families. The CBP fostered all forms of community cultural wealth capital. Study findings can inform educational leaders seeking to develop mutually beneficial partnerships between education institutions and community organizations to support student success

Serial Mediation Analysis Of Psychological Inflexibility And Daytime Insomnia Rumination In The Relationship Between Dysfunctional Beliefs About Sleep And Insomnia In College Students, Guadalupe G. San Miguel, Mercedes G. Woolley, Eric B. Lee, Brooke M. Smith, Demi Culianos, Michael E. Levin, Michael P. Twohig

Psychology Faculty Publications

Emerging research suggests that psychological inflexibility may be a factor contributing to the development and maintenance of insomnia. However, less is known about the potential cognitive pathways that may explain this relationship. In this study, we investigated the serial mediating effects of psychological inflexibility and daytime insomnia related rumination on the association between dysfunctional beliefs and attitudes about sleep (DBAS) and insomnia symptoms. The sample included 490 college students who underwent assessments at two time points over a one-month period. The results of our mediational tests yielded significant indirect effects, supporting the prediction that psychological inflexibility and daytime insomnia rumination …

Bridging The Nature-Cultural Heritage Gap: Evaluating Sustainable Entanglements Through Cemeteries In Urban Asia, David Ocon, Wei Ping Young

Research Collection School of Social Sciences

The expanding footprint of urban Asian settlements and increasing living standards have put pressure on cemetery sites. Public health narratives and the sanctity associated with death matters in Asian urban landscapes have fed into the rhetoric of cemeteries as undesirable heritage spaces. Often lacking protection, many cemeteries have been exhumed, cleared, and relocated to allow room for new developments and infrastructure, risking the survival of this quiet element of the urban cultural patrimony. Within an Asian context, synergies between nature and cultural heritage preservation are not prevalent in major cities like Singapore, Hong Kong, Tokyo, Manila, Kuala Lumpur, and Bangkok. …

Cash, Crowds, And Cooperation: The Effects Of Population Density And Resource Scarcity On Cooperation In The Dictator Game, Tan Kai Lin, Lynn, Norman P. Li, Kenneth Tan

Research Collection School of Social Sciences

The adaptive benefits of cooperation among humans have been widely studied. However, is being cooperative always adaptive across various combinations of ecological conditions? Existing work has focused on cultural, inter-, and intra-individual predictors of cooperation yet there is a lack of research on how an individual's ecology may come into play. In this work, we focus on the interaction of two ecological factors—population density and resource scarcity—on cooperation. Population density is often accompanied by social competition for limited resources. We hypothesise that in response to cues of high (versus low) population density, people facing resource-scarcity would adaptively lower their cooperativeness, …

Hot At The Top: The Influence Of Self-Rated Attractiveness On Self-Perceived Status, Lynn K. L. Tan, Michal Folwarczny, Tobias Otterbring, Norman P. Li

Research Collection School of Social Sciences

Beautism reflects the phenomenon of a widespread positivity bias that physically attractive people enjoy. This bias results in more attractive people receiving more positive social judgments, interactions, and economic outcomes. However, the literature has largely focused on third-party judgments of physical attractiveness, neglecting examinations of how self-rated attractiveness may predict self-evaluations. We sought to address this gap by examining how self-rated attractiveness predicts self-inferred social status, which is related to a myriad of psychosocial outcomes. Across one pilot test, one cross-sectional study, and a between-subjects experiment, we find converging evidence for the notion that self-rated physical attractiveness positively predicts higher …

How Does This End?: The Ukraine War And The Future Of Russia, Jonathan M. Acuff, Hannah N. Clegg

Journal of Strategic Security

We analyze a range of future scenarios for Russia related to the Ukraine War. Although regime change is a publicly-stated objective for several leaders of NATO countries, we find very little prospect for it. The Russian economy has largely evaded the effects of the sanctions. Despite enormous casualties and incompetence in the management of the war, both Putin and the war remain popular with the Russian public. Contrary to most analysis to date, the Wagner Group mutiny of June 2023 is not an indication of Putin’s weakness, but his strength. The coercive mechanisms of the Russian state remain intact. Indeed, …

Progress And Challenges In Combating Corruption In Ukraine: Pathways Forward, Semen Kravtsov, Kostiantyn Orobets, Nataliia Shyshpanova, Oksana Vovchenko, Olena Berezovska-Chmil

Journal of Strategic Security

In the context of war, the issue of corruption in Ukraine and abuse of office attracts great attention from experts, scholars, and civil society. The article aims to highlight the dynamics of combating corruption in Ukraine. This includes its main challenges, achievements, and ways of overcoming them in the context of war. The paper employs analysis and synthesis methods to study the dynamics of combating corruption in Ukraine. The authors have reviewed reforms in various sectors to identify key achievements in each corruption risk area. The article highlights the key achievements in the dynamics of combating corruption in Ukraine during …

Making Us Security Cooperation In Fragile States Work: Organizational Capital In Aid Provision, Randell Yi, Edward J. O'Connell

Journal of Strategic Security

The article examine how materiel and non-materiel organizational capital, as conveyed by military aid, differ in their effects on recipient nations with respect to governance. The authors analyze the Varieties of Democracy (vDem) dataset’s Regime Corruption Index alongside Security Sector Assistance expenditures as reported by the US Aid to Security Sector Actors (USASSA) dataset. They find that non-materiel forms of investment toward building partner nation capacity create generally better governance outcomes than materiel ones that involve transfers of weapons systems or supplies. They further contend that investments toward social cohesion and norms transmission “build the capacity to have capacity built.” …

Us Military Foreign Disaster Relief: Challenges And Proposed Mitigations, James M. Ward

Journal of Strategic Security

Climate Change will increase the frequency and intensity of disasters necessitating United States Department of Defense (DoD) intervention. The US Congress and DoD have produced reports and demanded action for climate change-related security concerns, but have largely left foreign disaster relief capacity unaddressed. The DoD does not have dedicated force structure for humanitarian assistance and disaster relief (HA/DR), potentially compromising mission readiness and operational effectiveness as well as jeopardizing U.S. foreign interests. Proposed mitigations for the status quo include bolstering international organizations, expanding the United States Agency for International Development (USAID) capacity to respond to disasters, and creating dedicated DoD …

Video Games And Radical Movements: "Ein Prozent" And "Heimat Defender", Göksel Türker, Ali Gök

Journal of Strategic Security

The far-right, which poses a threat of escalating into terrorism or inciting violence, employs a variety of tactics to spread its ideologies among the general public. In this context, "Heimat Defender: Rebellion," a two-dimensional video game supported by the far-right Ein Prozent operating in Germany, draws attention. In the study, the game in question was examined on the far-right and especially Ein Prozent ideology and subjected to discourse analysis. The analysis revealed that the game plot was shaped according to the friend-enemy perception of Ein Prozent and the far-right. Accordingly, in the game in question, opposition to multiculturalism, immigration, globalism, …

The Handbook Of African Intelligence Cultures. Ryan Shaffer, Editor. London: Rowman & Littlefield, 2023., Edward M. Roche Ph.D., Jd

Journal of Strategic Security

No abstract provided.

Precision: A History Of American Warfare. By James Patton Rogers. Manchester, England: Manchester University Press, 2023., Amos C. Fox

Journal of Strategic Security

No abstract provided.

Cold Rivals: The New Era Of Us-China Strategic Competition Ed. Evan S. Medeiros, Georgetown University Press, 2023., Mark T. Peters Ii Ph.D.

Journal of Strategic Security

No abstract provided.

Nuclear War: A Scenario By Annie Jacobson, New York: Dutton, 2024., Edward M. Roche, Ph.D., Jd

Journal of Strategic Security

No abstract provided.

Paying A Heavy Price: Costs Of Care For People With Severe Obesity In Nursing Homes, Luisa Fernandez, Bianca Shieu, Alison Trinkoff, Nicholas Castle, David G Wolf, Steven Handler, John A Harris

Faculty, Staff and Student Publications

Background and objectives: The prevalence of resident obesity in nursing homes has increased dramatically from 22% to 28% between 2005 and 2015. To provide care for people with obesity, nursing homes have changed their admissions, staffing, and equipment, but underlying these changes are increased resources and financial costs of care. The purpose of this study is to describe nursing home organizational aspects of caring for older adults with obesity, with a focus on economic factors, from the perspective of nursing home staff and leadership.

Research design and methods: This qualitative study used descriptive approaches; data were collected through semistructured telephone …

Developmental Patterns And Social Determinants Of Adolescent Polysubstance Use Among Connecticut Youth, Jennika K. Jenkins

Psychology Theses & Dissertations

Adolescent substance use continues to be a leading health concern in the United States. Although individual substance trends have demonstrated a decrease in use, it seems as if polysubstance use is on the rise among this population. Prior research into adolescent polysubstance use patterns tends to include only commonly used substances (e.g., alcohol, cannabis, tobacco) and neglects prescription drug misuse and illicit substances. Further, subanalyses by grade are typically not completed, leaving a gap in our understanding of developmentally appropriate prevention strategies. The present study utilized 13 substance use indicator variables to estimate substance use patterns among adolescents in grades …

The Years Of Embers In Mauritania: Ethnicity And Narratives, Hawa Saidou Barane Ba

Graduate Program in International Studies Theses & Dissertations

The borders in Africa were drawn according to the interests of colonial powers and without consideration of the continent’s ethnic, cultural, and linguistic realities. Thus, roughly 80% of African countries borders were drawn without considering the crucial and pre-existing realities of pre-colonial African societies, splitting ethnically and culturally homogenous groups and grouping diverse others under the same political unit. (Beck, 1993; Lefebvre, 2011). Consequently, many African countries end up with an ethnically diverse population that faces the challenge of living harmoniously together in social cohesion, creating an environment prone to ethnic conflicts, political instabilities, and weak national identities. Mauritania, for …

Theoretical Semi-Quantitative Risk Assessment Methodology For Tunnel Design And Construction Processes, Ozgur Satici, Esra Satici

Geosciences and Geological and Petroleum Engineering Faculty Research & Creative Works

All engineering projects involve risk management applications. Sometimes, risks cannot be effectively managed, leading to catastrophic consequences. Engineers must consciously or unconsciously manage these risks. Regardless of how risks are handled, project risks need to be systematically evaluated. Therefore, risk management procedures must be implemented in every project, particularly in geo-engineering projects, to mitigate undesirable consequences and achieve project objectives. However, the use of risk management procedures in underground excavation projects is not common. Numerous commonly employed underground excavation techniques lack assessment of risks, notably geotechnical risks. Most of them only evaluate rock structures and excavation stability in accordance with …

Magnetic Properties Of Diluted Hexaferrites, Logan Sowadski, Sean Anderson, Cameron Lerch, Julia E. Medvedeva, Thomas Vojta

Physics Faculty Research & Creative Works

We revisit the magnetic properties of the hexagonal ferrite PbFe_12-xGa_xO₁₉. Recent experiments have reported puzzling dependences of the ordering temperature and the saturation magnetization on the Ga concentration x. To explain these observations, we perform large-scale Monte Carlo simulations, focusing on the effects of an unequal distribution of the Ga impurities over the five distinct Fe sublattices. Ab initio density-functional calculations predict that the Ga ions preferably occupy the 12k sublattice and (to a lesser extent) the 2a sublattice. We incorporate this insight into a nonuniform model of the Ga distribution. Monte Carlo simulations …

Competing With The Platform: Complementor Positioning And Cross-Platform Response To Entry, Aldona Kapacinskaite, Ahmadreza Mostajabi

Research Collection Lee Kong Chian School Of Business

Research SummaryThis study contrasts traditional entry dynamics with platform owner entry into a complementor market and examines cross-platform complementor response to competition with the platform. Generalists experience low repositioning cost and are more likely to shift effort away, while specialists focus their effort on the focal platform. We examine Apple's “Files” app entry and find support for our hypotheses: generalists shift effort toward the competing platform, while specialists double down on the focal platform. Moreover, empirically comparing Apple's entry with that of other large firms, we find that only the platform owner elicits a strong complementor response. This article contributes …

The Impact Of Islam On Malaysia Before Independence, Sadiqa Binti Abdul Rahman

Journal of Middle East and Islamic Studies

This article discusses the influence and significance of the introduction of Islam in the Malaya on Malays before achieving independence. Prior to the advent of Islam, the Malaya was heavily influenced by several belief systems, including Hinduism, Animism, Buddhism, Dynamism, Hyang, and others. Nevertheless, Malaya, like other regions influenced by Islamic Civilization, has embraced the Sunnah teachings of Prophet Muhammad. Since 12 AD, the way of life in Malaya has been firmly rooted in Islamic teachings. The research objectives are to examine the general background of Malaysia and analyse the impact of the arrival of Islam in Malaya on the …

Behavioral Therapies Targeting Reward Mechanisms In Substance Use Disorders, Margaret C Wardle, Heather E Webber, Jin H Yoon, Angela M Heads, Angela L Stotts, Scott D Lane, Joy M Schmitz

Faculty, Staff and Student Publications

Behavioral therapies are considered best practices in the treatment of substance use disorders (SUD) and used as first-line approaches for SUDs without FDA-approved pharmacotherapies. Decades of research on the neuroscience of drug reward and addiction have informed the development of current leading behavioral therapies that, while differing in focus and technique, have in common the overarching goal of shifting reward responding away from drug and toward natural non-drug rewards. This review begins by describing key neurobiological processes of reward in addiction, followed by a description of how various behavioral therapies address specific reward processes. Based on this review, a conceptual …

High-Dimensional Multivariate Analysis Of Variance Via Geometric Median And Bootstrapping, Guanghui Cheng, Ruitao Lin, Liuhua Peng

Faculty, Staff and Student Publications

The geometric median, which is applicable to high-dimensional data, can be viewed as a generalization of the univariate median used in 1-dimensional data. It can be used as a robust estimator for identifying the location of multi-dimensional data and has a wide range of applications in real-world scenarios. This paper explores the problem of high-dimensional multivariate analysis of variance (MANOVA) using the geometric median. A maximum-type statistic that relies on the differences between the geometric medians among various groups is introduced. The distribution of the new test statistic is derived under the null hypothesis using Gaussian approximations, and its consistency …

Optimization And Validation Of Multi-Echo, Multi-Contrast Sage Acquisition In Fmri, Elizabeth G Keeling, Maurizio Bergamino, Sudarshan Ragunathan, C Chad Quarles, Allen T Newton, Ashley M Stokes

Faculty, Staff and Student Publications

The purpose of this study was to optimize and validate a multi-contrast, multi-echo fMRI method using a combined spin- and gradient-echo (SAGE) acquisition. It was hypothesized that SAGE-based blood oxygen level-dependent (BOLD) functional MRI (fMRI) will improve sensitivity and spatial specificity while reducing signal dropout. SAGE-fMRI data were acquired with five echoes (2 gradient-echoes, 2 asymmetric spin-echoes, and 1 spin-echo) across 12 protocols with varying acceleration factors, and temporal SNR (tSNR) was assessed. The optimized protocol was then implemented in working memory and vision tasks in 15 healthy subjects. Task-based analysis was performed using individual echoes, quantitative dynamic relaxation times …