Digital Commons Network^™

Correlations Of Physical And Psychological Health In Parents Of Individuals With Autism Spectrum Disorder, Norah L. Johnson, Abir K. Bekhet, Emily Zint, June Wang, Sylvia Peña, Amy V. Van Hecke, Mauricio Garnier-Villarreal, Alexander V. Ng

College of Nursing Faculty Research and Publications

Background: Individuals with autism spectrum disorder (ASD) have social communication difficulties and restricted, repetitive, and/or sensory behaviors or interests. The prevalence of ASD is now 1 in 36 individuals. Parents of individuals with ASD face challenges that can affect their physical and psychological wellbeing.

Objective: With the long-term goal to tailor an exercise program, the purpose of this study was 2-fold: (1) establish the baseline physical and mental health of parents of individuals with ASD and (2) estimate the relationship of physiologic variables with psychological variables of health for parents of individuals with ASD.

Methods: This descriptive, cross-sectional study (N …

Enhancing Social And Emotional Competencies In Rural Middle School Students: A Cluster-Randomized Study On Character Playbook, Gina Ricker Phd, Joanne Angosta

The Rural Educator

This cluster-randomized pre-post study examined the effectiveness of Character Playbook, a digitally delivered, universal social-emotional learning (SEL) program, in enhancing social and emotional knowledge and confidence among rural middle school students. Pre- and post-assessments and surveys measured students’ knowledge and self-reported confidence related to social and emotional skills. The sample consisted of 128 students from two rural middle schools. Analyses of covariance with multiple imputations to account for missing data revealed that students who participated in Character Playbook demonstrated significantly higher knowledge and more positive confidence toward their social and emotional learning competency than the control group. These findings, with …

Author Correction: The Evolution Of Lung Cancer And Impact Of Subclonal Selection In Tracerx, Alexander M Frankell, Michelle Dietzen, Maise Al Bakir, Emilia L Lim, Takahiro Karasaki, Sophia Ward, Selvaraju Veeriah, Emma Colliver, Ariana Huebner, Abigail Bunkum, Mark S Hill, Kristiana Grigoriadis, David A Moore, James R M Black, Wing Kin Liu, Kerstin Thol, Oriol Pich, Thomas B K Watkins, Cristina Naceur-Lombardelli, Daniel E Cook, Roberto Salgado, Gareth A Wilson, Chris Bailey, Mihaela Angelova, Robert Bentham, Carlos Martínez-Ruiz, Christopher Abbosh, Andrew G Nicholson, John Le Quesne, Dhruva Biswas, Rachel Rosenthal, Clare Puttick, Sonya Hessey, Claudia Lee, Paulina Prymas, Antonia Toncheva, Jon Smith, Wei Xing, Jerome Nicod, Gillian Price, Keith M Kerr, Babu Naidu, Gary Middleton, Kevin G Blyth, Dean A Fennell, Martin D Forster, Siow Ming Lee, Mary Falzon, Madeleine Hewish, Michael J Shackcloth, Eric Lim, Sarah Benafif, Peter Russell, Ekaterini Boleti, Matthew G Krebs, Jason F Lester, Dionysis Papadatos-Pastos, Tanya Ahmad, Ricky M Thakrar, David Lawrence, Neal Navani, Sam M Janes, Caroline Dive, Fiona H Blackhall, Yvonne Summers, Judith Cave, Teresa Marafioti, Javier Herrero, Sergio A Quezada, Karl S Peggs, Roland F Schwarz, Peter Van Loo, Daniël M Miedema, Nicolai J Birkbak, Crispin T Hiley, Allan Hackshaw, Simone Zaccaria, Tracerx Consortium, Mariam Jamal-Hanjani, Nicholas Mcgranahan, Charles Swanton

Faculty, Staff and Student Publications

No abstract provided.

“I Know How Much He Cares For Our Learning”: Moral Life In University Elt Classrooms, Leila Tajik, Seyyed Abdolhamid Mirhosseini, Mahsa Kashkooli

The Qualitative Report

In Iran’s higher education English language teaching (ELT) context, we explored the moral nuances embedded in two conversation courses offered to undergraduate students majoring in English Literature at one of the branches of the Islamic Azad University (IAU) in Tehran. We collected data through classroom observations, field notes, and semi-structured individual and focus group interviews. Our content analysis revealed a range of moral values embedded in significant incidents, which we categorized into five themes: (a) relations, (b) rules and regulations, (c) assessment, (d) curricular substructure, and (I) culture. These themes were further subcategorized into more specific concepts that emerged from …

Singer’S Guide To Hak Jun Yoon’S Selected Art Songs, Sunmin Cha

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Composer Hak Jun Yoon is at the forefront of popularizing Korean art songs through the combination of artistry and mass appeal, positioning him as one of the representative composers of contemporary Korea. Recently, Yoon’s songs gained significant popularity after being featured on the Korean vocal competition TV program “Phantom Singer,” playing a major role in sparking public interest in Korean art songs in general. This document aims to widen that circle to more classical singers by analyzing poetic and musical elements in four of Yoon’s representative songs: “On the Way to You,” “A Flower Blooms Alone,” “Lingering Scent,” and “The …

At-Risk Tackling Techniques And Effectiveness In English Premiership Rugby, Brady P Moore, Dakota Doucet, Bobby Dow, Sree M Vemu, Takashi Hirase, Rex A W Marco

Faculty, Staff and Student Publications

Background: Head-down tackling has been associated with higher rates of head and neck injuries and less successful tackles compared with head-up tackling in American football. In rugby, head and neck injuries have been associated with tackling, with the tackler's head positioned in front of the ball carrier.

Purpose: To assess the success and risks of tackling techniques used in the English Rugby Premiership matches.

Study design: Cross-sectional study; Level of evidence, 3.

Methods: Three reviewers analyzed 1000 consecutive solo defensive tackling attempts during the 2022 to 2023 season in 6 English Rugby Premiership matches. Slow-motion replays were used to analyze …

Parallel Degradome-Seq And Dms-Mapseq Substantially Revise The Mirna Biogenesis Atlas In Arabidopsis, Xingxing Yan, Changhao Li, Kaiye Liu, Tianru Zhang, Qian Xu, Xindi Li, Jiaying Zhu, Ziying Wang, Anikah Yusuf, Shuqing Cao, Xu Peng, James J Cai, Xiuren Zhang

Faculty, Staff and Student Publications

MicroRNAs (miRNAs) are produced from highly structured primary transcripts (pri-miRNAs) and regulate numerous biological processes in eukaryotes. Due to the extreme heterogeneity of these structures, the initial processing sites of plant pri-miRNAs and the structural rules that determine their processing have been predicted for many miRNAs but remain elusive for others. Here we used semi-active DCL1 mutants and advanced degradome-sequencing strategies to accurately identify the initial processing sites for 147 of 326 previously annotated Arabidopsis miRNAs and to illustrate their associated pri-miRNA cleavage patterns. Elucidating the in vivo RNA secondary structures of 73 pri-miRNAs revealed that about 95% of them …

Delayed Hip Arthroscopy For Femoroacetabular Impingement Syndrome Does Not Increase Revision But Does Increase Rates Of Chronic Opiate Use, Kian Niknam, Ryan Freshman, Sergio E Flores, Drew A Lansdown, Stephanie E Wong, Alan L Zhang

Faculty, Staff and Student Publications

Introduction: In recent years, the utilization of hip arthroscopy to treat femoroacetabular impingement syndrome (FAIS) has increased due to its low complication rates, positive impact on patient-reported outcomes (PROs), and association with faster rehabilitation. Despite this, there are high rates of revision and conversion to total hip arthroplasty (THA) in some of these patients. It is unclear whether time from initial FAIS diagnosis to surgery is a risk factor for poor outcomes. In this study, we examined the relationship between timing of hip arthroscopy for FAIS and rates of 2-year revision hip procedures, 2-year conversion to total hip arthroplasty (THA), …

Is There A Therapeutic Role For Immunosuppression For Gastrointestinal Involvement In Patients With Systemic Sclerosis?, Zsuzsanna H Mcmahan, Michael Hughes

Faculty, Staff and Student Publications

No abstract provided.

Outcomes Of Bridging Intravenous Thrombolysis Versus Endovascular Therapy Alone In Late-Window Acute Ischemic Stroke, Jelle Demeestere, Muhammad M Qureshi, Lieselotte Vandewalle, Anke Wouters, Daniel Strbian, Raul G Nogueira, Simon Nagel, Hiroshi Yamagami, Volker Puetz, Mohamad Abdalkader, Diogo C Haussen, Mahmoud H Mohammaden, Markus A Möhlenbruch, Marta Olivé-Gadea, Simon Winzer, Marc Ribo, Patrik Michel, João Pedro Marto, Kanta Tanaka, Shinichi Yoshimura, Nicolas Martinez-Majander, Francois Caparros, Hilde Henon, Liisa Tomppo, Anne Dusart, Flavio Bellante, João Nuno Ramos, Jessica Jesser, Sunil A Sheth, Santiago Ortega-Gutiérrez, James E Siegler, Stefania Nannoni, Johannes Kaesmacher, Tomas Dobrocky, Sergio Salazar-Marioni, Mudassir Farooqui, Pekka Virtanen, Rita Ventura, Syed F Zaidi, Alicia C Castonguay, Kazutaka Uchida, Ajit S Puri, Nobuyuki Sakai, Kazunori Toyoda, Behzad Farzin, Hesham E Masoud, Piers Klein, Jenny Bui, Federica Rizzo, Daniel P O Kaiser, Philippe Desfontaines, Davide Strambo, Charlotte Cordonnier, Eugene Lin, Peter A Ringleb, Daniel Roy, Osama O Zaidat, Urs Fischer, Jean Raymond, Robin Lemmens, Thanh N Nguyen

Faculty, Staff and Student Publications

Background: Studies comparing bridging intravenous thrombolysis (IVT) with direct endovascular therapy (EVT) in patients with acute ischemic stroke who present late are limited. We aimed to compare the clinical outcomes and safety of bridging IVT in patients with acute ischemic stroke due to anterior circulation large vessel occlusion who underwent EVT 6 to 24 hours after time last known well.

Methods: We enrolled patients with anterior circulation large vessel occlusion stroke and a National Institutes of Health Stroke Scale score of ≥6 from 20 centers across 10 countries in the multicenter retrospective CLEAR study (CT for Late Endovascular Reperfusion) between …

Long-Term Weight Loss Effects Of Semaglutide In Obesity Without Diabetes In The Select Trial, Donna H Ryan, Ildiko Lingvay, John Deanfield, Steven E Kahn, Eric Barros, Bartolome Burguera, Helen M Colhoun, Cintia Cercato, Dror Dicker, Deborah B Horn, G Kees Hovingh, Ole Kleist Jeppesen, Alexander Kokkinos, A Michael Lincoff, Sebastian M Meyhöfer, Tugce Kalayci Oral, Jorge Plutzky, André P Van Beek, John P H Wilding, Robert F Kushner

Faculty, Staff and Student Publications

In the SELECT cardiovascular outcomes trial, semaglutide showed a 20% reduction in major adverse cardiovascular events in 17,604 adults with preexisting cardiovascular disease, overweight or obesity, without diabetes. Here in this prespecified analysis, we examined effects of semaglutide on weight and anthropometric outcomes, safety and tolerability by baseline body mass index (BMI). In patients treated with semaglutide, weight loss continued over 65 weeks and was sustained for up to 4 years. At 208 weeks, semaglutide was associated with mean reduction in weight (-10.2%), waist circumference (-7.7 cm) and waist-to-height ratio (-6.9%) versus placebo (-1.5%, -1.3 cm and -1.0%, respectively; P < 0.0001 for all comparisons versus placebo). Clinically meaningful weight loss occurred in both sexes and all races, body sizes and regions. Semaglutide was associated with fewer serious adverse events. For each BMI category (

A Word From The Writing Team (July 2024), Pam Walter, Mfa

A Word From the Writing Team (Newsletter)

This issue includes:

• Publication Spotlight
• Join Us for Summer Writing Time
• For FY24-25, the Open Access Publishing Fund Process is Changing
• Jefferson has Funding Agreements with Specific Publishers
• The OPWPC Canvas Page Offers Helpful Tools
• Scott Memorial Library Archive Renovations are Done!

Elementary Teachers' Self-Efficacy And Its Role In Stem Implementation, Caroline Buechel, Michael K. Daugherty, Vinson Carter, Emine Sahin Topalcengiz

Curriculum and Instruction Faculty Publications and Presentations

To equip students with 21st-century skills, teachers must have both deep STEM content knowledge and the confidence to implement and teach appropriate STEM content. Many elementary teachers have inadequate STEM background knowledge, low confidence, and STEM self-efficacy for implementing STEM in the classroom; as a result, teachers' classroom practices are affected. The study examined how elementary teachers perceive their ability to implement STEM in the classroom. The STEM Efficacy Survey was sent to a randomized pool of 100 elementary educators, and 18 of them agreed to participate in the study. This instrument was designed to elicit responses related to the …

Reduced Oxygen Desaturation In The Vastus Lateralis Of Chronic Stroke Survivors During Graded Muscle Contractions, Allison S. Hyngstrom, Jennifer N. Nguyen, Spencer A. Murphy, Stephanie C. Raab, Brian D. Schmit, David D. Gutterman, Matthew J. Durand

Physical Therapy Faculty Research and Publications

Background

Few studies have examined changes in skeletal muscle physiology post-stroke. This study examined changes in tissue oxygen saturation (StO₂) of the vastus lateralis (VL) muscle of stroke survivors and age-matched control participants during maximal and submaximal isometric contractions of the knee extensor muscles.

Objectives

We hypothesized that tissue oxygen desaturation (ΔStO₂) during knee extensor muscle contractions would be less in the VL in the paretic vs. the non-paretic and control legs.

Methods

Ten chronic stroke survivors (>6 months post-stroke) with lower extremity muscle weakness and 10 age-matched controls completed this prospective cohort study. Maximum …

“What Memory Wants From Me”: Contemporary Female Writers On The Calling To Remember, Daria Smirnova

Theses and Dissertations

This dissertation explores the intersections of transnational memory studies and feminist autobiographical writing through the works of Maria Stepanova, Annie Ernaux, and Lea Ypi. It argues that contemporary literature, especially that written by women, provides innovative frameworks for understanding identity, memory, and the sociopolitical context of our time. By examining how these authors intertwine personal and collective histories, the study highlights the shift in memory studies from monumental, nation-centered history to transnational, mobile memory modalities. I have pinpointed three themes to which these authors significantly contribute within the feminist and political discourse on memory: the relationship between gender and memory, …

Ap Art History For Marshall Public Schools, Gage Bunting

Theses

Advanced Placement Art History (AP Art History) is a course that, while being one of the less popular AP offerings, exists in thousands of schools already. College Board is the institution that facilitates these courses and sets the requirements each school must follow in order to offer the course. With that said, there is not a rigid requirement that all courses be taught in the same manner, and because of that, the curriculum of this project was adapted to enhance learning for students of Marshall High School.

The art department of Marshall High School has evolved in recent years and …

Data For All: Creating A Sustainable Community Partnership To Increase Health And Racial Equity, Emily Zoe Mann

Tampa Library Faculty and Staff Publications

This poster discusses the formation of a collaborative partnership between several community institutions including an academic library, public library and center for health equity in order to increase community data literacy working towards racial equity within the community. We will discuss working across communities to assess needs and how to meet needs within the different community guidelines, strategic goals, and theories of change. The overarching goal of this ongoing project is to make data less intimidating and empower our community to use local data to create local change. In an effort increase collaborative work in different communities there will be …

Three Essays On Environmental, Social, And Governance (Esg), Zhengwei Fu

Theses and Dissertations

This abstract synthesizes findings from three studies examining the impact of environmental, social, and governance (ESG). In essay one, using environmental regulatory enforcement data from EPA, I find that facility-level political connections are positively related to the likelihood of experiencing environmental regulatory enforcement. The effect is mainly driven by political connections related to Democratic senators. Consequently, politically connected facilities reduce their air pollution. The effect of political connection is diminished when the authority of senators over environmental regulatory enforcement becomes weaker after the 2017 presidential election. Heterogeneity analyses reveal that the impact of political connection is stronger in states with …

The Philosophy Of Incarceration And Punishment And Its Evolvement. Is It Enough?, Katherine Sebok

Capstone Projects – Politics and Government

This research project explores the evolution of incarceration philosophies and their disconnect from outdated prison infrastructure in the United States, with a focus on Illinois. From ancient civilizations’ reliance on retributive justice to the modern era’s emphasis on rehabilitation, punishment practices have evolved, yet many facilities remain stuck in the past. The “tough-on-crime” era deepened the divide, leading to overcrowding and neglect. While recent reforms prioritize rehabilitation, progress is hindered by outdated facilities. Illinois’ plans to demolish and rebuild Logan and Stateville Correctional Centers offer renewed hope, but the lengthy process requires significant investment and commitment from all involved parties.

A Narrative Review Of Little League Shoulder: Proximal Humeral Physis Widening Is Only One Piece Of The Puzzle, It Is Time To Consider Posterior Glenoid Dysplasia, Natalie L Myers, Sean M Kennedy, Amanda J Arnold, Zachary A Gehring, Kaylin J Kruseman, John E Conway, Russ M Paine, Lane B Bailey, J Craig Garrison

Faculty, Staff and Student Publications

Baseball athletes across all levels of play are at an increased risk for upper extremity injury due to the supraphysiologic demands on the shoulder and elbow during overhead throwing. Little league baseball players present with a unique subset of injuries that can affect the growth plate, commonly at the shoulder or the elbow. Ascertaining a diagnosis and plan of care for little league shoulder (LLS) historically focuses on the proximal humeral physis in skeletally immature throwing athletes presenting with shoulder pain. However, while not a current standard of care, posterior glenoid dysplasia is often present in youth baseball athletes presenting …

Author Correction: Mediators Of Necroptosis: From Cell Death To Metabolic Regulation, Xiaoqin Wu, Laura E Nagy, Jérémie Gautheron

Faculty, Staff and Student Publications

No abstract provided.

Hyperglycemia Is Associated With Computed Tomography Perfusion Core Volume Underestimation In Patients With Acute Ischemic Stroke With Large-Vessel Occlusion, Arash Niktabe, Juan Carlos Martinez-Gutierrez, Sergio Salazar-Marioni, Rania Abdelkhaleq, Juan Carlos Rodriguez Quintero, Jerome A Jeevarajan, Muhammad Bilal Tariq, Ananya S Iyyangar, Hussain M Azeem, Anjan Nagesh Ballekere, Ngoc Mai Le, Louise D Mccullough, Sunil A Sheth, Youngran Kim

Faculty, Staff and Student Publications

Background: CT Perfusion (CTP) predictions of infarct core play an important role in the determination of treatment eligibility in large vessel occlusion (LVO) acute ischemic stroke (AIS). Prior studies have demonstrated that blood glucose can affect cerebral blood flow (CBF). Here we examine the influence of acute and chronic hyperglycemia on CTP estimations of infarct core.

Methods: From our prospectively collected multi-center observational cohort, we identified patients with LVO AIS who underwent CTP with RAPID (IschemaView, Stanford, CA) post-processing, followed by endovascular therapy with substantial reperfusion (TICI 2b-3) within 90 minutes, and final infarct volume (FIV) determination by MRI 48-72 …

The Time-Dependent Association Between Irritable Bowel Syndrome And All-Cause And Cause-Specific Mortality: A Prospective Cohort Study Within The Uk Biobank, Fangyu Li, Yukiko Yano, Lola Étiévant, Carrie R Daniel, Shreela V Sharma, Eric L Brown, Ruosha Li, Erikka Loftfield, Qing Lan, Rashmi Sinha, Baharak Moshiree, Maki Inoue-Choi, Emily Vogtmann

Faculty, Staff and Student Publications

Introduction: Irritable bowel syndrome (IBS) is one of the most common functional gastrointestinal disorders, but few studies have evaluated mortality risks among individuals with IBS. We explored the association between IBS and all-cause and cause-specific mortality in the UK Biobank.

Methods: We included 502,369 participants from the UK Biobank with mortality data through 2022. IBS was defined using baseline self-report and linkage to primary care or hospital admission data. We estimated hazard ratios (HRs) and 95% confidence intervals (CIs) for all-cause and cause-specific mortality using multivariable Cox proportional hazards regression models within partitioned follow-up time categories (0-5, >5-10, and >10 …

Social Media And Dermatology During The Covid-19 Pandemic: Analyzing User-Submitted Posts Seeking Dermatologic Advice On Reddit, Vivek V Shukla, Benjamin A Carper, Namasivayam Ambalavanan, Matthew A Rysavy, Edward F Bell, Abhik Das, Ravi M Patel, Carl T D'Angio, Kristi L Watterberg, C Michael Cotten, Stephanie L Merhar, Myra H Wyckoff, Pablo J Sánchez, Neha Kumbhat, Waldemar A Carlo, Eunice Kennedy Shriver National Institute Of Child Health And Human Development Neonatal Research Network

Faculty, Staff and Student Publications

HYPOTHESIS: Increased social distancing was associated with a lower incidence of extremely preterm live births (EPLB) during the initial COVID-19 pandemic period.

STUDY DESIGN: Prospective study at the NICHD Neonatal Research Network sites comparing EPLB (22

RESULTS: EPLB and EPIS percentages did not significantly decrease (1.58-1.45%, p = 0.07, and 0.08-0.06%, p = 0.14, respectively). SDI was not significantly correlated with percent change of EPLB (CC = 0.29, 95% CI = -0.12, 0.71) or EPIS (CC = -0.23, 95% CI = -0.65, 0.18). Percent change in mean gestational age was positively correlated with SDI (CC = 0.49, 95% CI = …

Expanded-Access Use Of Elamipretide In A Patient With Membrane Protein-Associated Neurodegeneration, Jorge Patino, Anna Haertling Clearman, Lindsey Miller, Mary Kay Koenig

Faculty, Staff and Student Publications

This case report presents a progressively declining 17-year-old patient with membrane protein-associated neurodegeneration who demonstrated symptomatic improvements in her dysarthria, dysphagia, and gait, and objective improvements in her 6-minute walk test and 5 times sit-to-stand test during elamipretide treatment.

The Role Of Occipital Condyle And Atlas Anomalies On Occipital Cervical Fusion Outcomes In Chiari Malformation Type I With Syringomyelia: A Study From The Park-Reeves Syringomyelia Research Consortium, Alexander T Yahanda, Joyce Koueik, Laurie L Ackerman, P David Adelson, Gregory W Albert, Philipp R Aldana, Tord D Alden, Richard C E Anderson, David F Bauer, Tammy Bethel-Anderson, Karin Bierbrauer, Douglas L Brockmeyer, Joshua J Chern, Daniel E Couture, David J Daniels, Brian J Dlouhy, Susan R Durham, Richard G Ellenbogen, Ramin Eskandari, Herbert E Fuchs, Gerald A Grant, Patrick C Graupman, Stephanie Greene, Jeffrey P Greenfield, Naina L Gross, Daniel J Guillaume, Todd C Hankinson, Gregory G Heuer, Mark Iantosca, Bermans J Iskandar, Eric M Jackson, George I Jallo, James M Johnston, Bruce A Kaufman, Robert F Keating, Nickalus R Khan, Mark D Krieger, Jeffrey R Leonard, Cormac O Maher, Francesco T Mangano, Jonathan Martin, J Gordon Mccomb, Sean D Mcevoy, Thanda Meehan, Arnold H Menezes, Michael S Muhlbauer, Brent R O'Neill, Greg Olavarria, John Ragheb, Nathan R Selden, Manish N Shah, Chevis N Shannon, Joshua S Shimony, Matthew D Smyth, Scellig S D Stone, Jennifer M Strahle, Mandeep S Tamber, James C Torner, Gerald F Tuite, Elizabeth C Tyler-Kabara, Scott D Wait, John C Wellons, William E Whitehead, Tae Sung Park, David D Limbrick, Raheel Ahmed

Faculty, Staff and Student Publications

Objective: Congenital anomalies of the atlanto-occipital articulation may be present in patients with Chiari malformation type I (CM-I). However, it is unclear how these anomalies affect the biomechanical stability of the craniovertebral junction (CVJ) and whether they are associated with an increased incidence of occipitocervical fusion (OCF) following posterior fossa decompression (PFD). The objective of this study was to determine the prevalence of condylar hypoplasia and atlas anomalies in children with CM-I and syringomyelia. The authors also investigated the predictive contribution of these anomalies to the occurrence of OCF following PFD (PFD+OCF).

Methods: The authors analyzed the prevalence of condylar …

The Impact Of Hearing Impairment On Patient Care And Autonomy, Savannah Baimbridge, Julie Neil, Gabriel M Aisenberg

Faculty, Staff and Student Publications

Sensory deficits, including hypoacusis, can cause a barrier to communication between healthcare providers and patients, which in turn can lead to misdiagnosis and loss of patient autonomy. Such deficits are frequently overlooked in clinical encounters. We present a 92-year-old Spanish-speaking female who presented twice to the Emergency Department for complications of a diabetic foot infection. Limited evaluation, documentation, and accommodations regarding the patient's hypoacusis led to a misinterpretation of her mental status and a transfer of decision-making to surrogates. A two-toe amputation, mechanical intubation, and intensive care unit stay were followed. It was only after these events that the caregivers …

Reproducibility Of Quantitative Myocardial Perfusion And Coronary Flow Capacity By Positron Emission Tomography: 3d Digital Silicon Photomultiplier Solid State Vs Legacy 2d Analogue Systems For Clinical Practice And Trials, Amanda Roby, Lindsey Harmon, Kelly Sander, Linh Bui, Danai Kitkungvan, Monica Patel, Jagat Narula, Nils P Johnson, K Lance Gould

Faculty, Staff and Student Publications

Aims: Quantitative rest-stress myocardial perfusion in millilitres per minute per gram among multiple 2D and 3D positron emission tomography-computed tomography (PET-CT) scanners is essential for personalized cardiac management and clinical trials. Accordingly, this study reports the accuracy and precision of quantitative rest-stress millilitres per minute per gram and coronary flow capacity among 2D and two different digital 3D silicon photomultiplier (SiPM) PET-CT scanners for quantifying the severity of coronary pathophysiology for clinical trials or guiding interventions vs. medical treatment.

Methods and results: One hundred seventy-one participants underwent 748 paired serial rest or stress PET perfusion imaging in the same person …

Use Of Ipsc-Derived Smooth Muscle Cells To Model Physiology And Pathology, Callie S Kwartler, Jose Emiliano Esparza Pinelo

Faculty, Staff and Student Publications

The implementation of human induced pluripotent stem cell (hiPSC) models has introduced an additional tool for identifying molecular mechanisms of disease that complement animal models. Patient-derived or CRISPR/Cas9-edited induced pluripotent stem cells differentiated into smooth muscle cells (SMCs) have been leveraged to discover novel mechanisms, screen potential therapeutic strategies, and model in vivo development. The field has evolved over almost 15 years of research using hiPSC-SMCs and has made significant strides toward overcoming initial challenges such as the lineage specificity of SMC phenotypes. However, challenges both specific (eg, the lack of specific markers to thoroughly validate hiPSC-SMCs) and general (eg, …

The Role Of Nr4a Transcription Factors In The Body And Their Effects In The Pancreatic Beta Cell, Jacob A. Herring

Theses and Dissertations

A central aspect of type 1 and type 2 diabetes is decreased functional β-cell mass which leads to systemic glucose dysregulation. Functional β-cell mass takes into account β-cell insulin secretion, β-cell proliferation, and β-cell survival. Several treatments are currently used to help maintain glucose levels in individuals with diabetes. However, cures for these diseases are not available due to inability to expand functional β-cell mass. Transcription factors control expression of target genes critical for various functions, and transcription factors that control β-cell function, proliferation and survival play a significant role in β-cell development and function. A more thorough examination of …