Digital Commons Network^™

Radiotherapy Promotes Cuproptosis And Synergizes With Cuproptosis Inducers To Overcome Tumor Radioresistance, Guang Lei, Mingchuang Sun, Jun Cheng, Rui Ye, Zhengze Lu, Amber Horbath, David Huo, Shengrong Wu, Anagha Alapati, Sadhna Aggarwal, Zhihao Xu, Chao Mao, Yuelong Yan, Jun Yao, Qidong Li, Xiong Chen, Hyemin Lee, Li Zhuang, Dadi Jiang, Apar Pataer, Jack A Roth, Nicholas Navin, Albert C Koong, Mingjian James You, Steven H Lin, Boyi Gan

Faculty, Staff and Student Publications

Cuproptosis is a recently identified form of copper-dependent cell death. Here, we reveal that radiotherapy (RT) induces cuproptosis in cancer cells, independent of apoptosis and ferroptosis, and depletes lipoylated proteins and iron-sulfur (Fe-S) cluster proteins-both hallmarks of cuproptosis-in patient tumors. Mechanistically, RT elevates mitochondrial copper levels by upregulating copper transporter 1 (CTR1) and depleting mitochondrial glutathione, a copper chelator, thereby triggering cuproptosis. Integrated analyses of RNA sequencing (RNA-seq) from radioresistant esophageal cancer cells and single-cell RNA-seq from esophageal tumors of patients unresponsive to RT link radioresistance to the downregulation of BTB and CNC homology 1 (BACH1). This downregulation de-represses the …

Promethia 2024-2025

Promethia

No abstract provided.

Inside Out: Autistic Psychologists On The Power Structures Of Diagnosis, Audrey J. Scaer, Christopher R. Dabbs

Ought: The Journal of Autistic Culture

How do relationships between medicalized diagnostic powers and training intersect with the complex social identity of autism? How does self-identification (self-diagnosis) challenge the diagnostic status quo, created and scaffolded by enormously powerful social systems? In this paper, we reflect on the historical and modern dynamics of these power relations. As autistic psychologists actively working with and diagnosing autistic clients, we end this paper with an autoethnographic interrogation of our own self-diagnostic journeys and ways in which we’ve integrated our identities across personal and professional spheres of functioning.

Beyond The Meadow: Exploring The Violence And Dynamics Of Power In Watership Down Through Critical Animal Studies And Cinematographic Lens, Marwa Hussein Abdelfattah

Arts and Design

This paper aims to analyze the 2018 Netflix miniseries adaptation of Richard Adams's classic novel, Watership Down, using Critical Animal Studies and a Cinematographic lens. The analysis focuses on its visual storytelling through the camera angles, lighting, and character representation. Adams’ novel was adapted three times. The first two animated versions were horrifying to the extent that one of them was banned. The most recent version used Computer-Generated Imagery (CGI) technology to be more friendly. The CGI version toned down explicit brutality while maintaining the novel's darker themes. Unlike the two previous versions, the CGI focused on inferred violence and …

The Influence Of Father Involvement On Early Childhood Outcome In China, Shuiyan Guo

Theses and Dissertations

Using a sample from China, this study examined the influence of father involvement on child outcome in early childhood in areas of internalizing problems, externalizing problems and prosocial behaviors. The participants were drawn from the larger PACIFIC project, a cross-cultural study of family processes in Asia. 479 families with a preschool or kindergarten child living in Beijing and Dalian, China were included in this study. Using multiple regression analysis, result indicated that father involvement was not significantly associated with child’s internalizing problems, externalizing problems, and prosocial behaviors. Moderation analysis was also conducted and found that the effect of father involvement …

Patterns Of Late Holocene And Historical Extinctions On Madagascar, Laurie R. Godfrey, Zachary S. Klukkert, Brooke E. Crowley, Robin R. Dawson, Peterson Faina, Benjamin Z. Freed, Evon Hekkala, Cortni Borgerson, Harimanjaka A.M. Rasolonjatovo, Patricia C. Wright, Stephen J. Burns

Department of Anthropology Faculty Scholarship and Creative Works

Around 1000 years ago, Madagascar experienced the collapse of populations of large vertebrates that ultimately resulted in many species going extinct. The factors that led to this collapse appear to have differed regionally, but in some ways, key processes were similar across the island. This review evaluates four hypotheses that have been proposed to explain the loss of large vertebrates on Madagascar: Overkill, aridification, synergy, and subsistence shift. We explore regional differences in the paths to extinction and the significance of a prolonged extinction window across the island. The data suggest that people who arrived early and depended on hunting, …

Patterns Of Late Holocene And Historical Extinctions On Madagascar, Laurie R. Godfrey, Zachary S. Klukkert, Brooke E. Crowley, Robin R. Dawson, Peterson Faina, Benjamin Z. Freed, Evon Hekkala, Cortni Borgerson, Harimanjaka A. M. Rasolonjatovo, Patricia C. Wright, Stephen J. Burns

EKU Faculty and Staff Scholarship

Around 1000 years ago, Madagascar experienced the collapse of populations of large vertebrates that ultimately resulted in many species going extinct. The factors that led to this collapse appear to have differed regionally, but in some ways, key processes were similar across the island. This review evaluates four hypotheses that have been proposed to explain the loss of large vertebrates on Madagascar: Overkill, aridification, synergy, and subsistence shift. We explore regional differences in the paths to extinction and the significance of a prolonged extinction window across the island. The data suggest that people who arrived early and depended on hunting, …

Television As Myth And Ritual

Communication Research Trends

Main issue abstract:

Every nation and culture finds a way to continually retell its folktales and myths. If once we did this around camp-fires and through wandering bards, today we recast our traditional stories in modem clothes through our most popular medium, television. Throughout the world the highest audience ratings are for folktale- like soap operas that embody our historical contests, heroes and villains, and, usually, happy endings. The American-produced Dallas and Dynasty are set in the old 'wild West' states ofTexas and Colorado - but extended into new frontiers of high finance and international intrigue. The BBC'sEastEnders celebrates the …

La Transition Linguistique Au Maroc : Ce Que La Langue Doit À La Réforme Et Vice Versa, El Ouafa Idriss

Dirassat

The 2023-2024 school year is unlike any other in terms of Moroccan language policy. The Ministry of National Education, Preschool and Sports has issued a circular calling on its various officials, players and stakeholders to generalize the use of the English language from secondary school level upwards. This new configuration, whose ultimate aim is to establish “linguistic pluralism in a progressive and balanced way”, starts with a sample of 10%, but intends to reach 100% in all public colleges by the 2025-2026 season. So what are the reasons for this choice? What does it say about the linguistic situation in …

Portuguese For Mozambican Mothers – A Language Empowerment App, Josh Kindarara, Alexandre Lopes, Gwendolyn Patwardhan, Riana Santos, Sara Wheeler

Computer Science and Engineering Senior Theses

In Mecúfi, Mozambique, the mothers of children who attend school through the DIFF EDUCATION program have a strong desire to learn Portuguese, the country’s national language, due to colonization. However, they have minimal formal education and little to no experience with technology. They are unable to read or write in any language, including their native language, Makhuwa, making many current educational resources unusable. This leaves these mothers without accessible, culturally relevant tools to help address their linguistic needs.

This project focuses on developing an educational application designed for non-literate mothers in rural Mozambique. The app emphasizes visual and auditory learning …

A First Look Into Parental Strategies, And Challenges Around Children’S Device Usage In Urban Nepal, Rizu Paudel, Prakriti Dumaru, Ankit Shrestha, Mahdi Nasrullah Al-Ameen

Computer Science Student Research

There have been substantial changes in the landscape of technology use by children in Global South during COVID-19, when the shift to online learning platforms necessitated parents to avail personal devices (e.g., smartphones, computers) for their children to fulfill their educational needs. However, the use of devices by children are not limited to serving educational purpose only. Our study positions itself in a critical post-pandemic period in Nepal, characterized by the increase in device use by children, while a little study to date, investigated parental mediation in this developing country. To this end, we conducted semi-structured interviews with 20 parents, …

Combining Remote And Collaborative Research: A Critical Reflection On Large-Scale, Comparative, And Interdisciplinary Research In Times Of A Global Crisis, Ferdiansyah Thajib, Thomas Stodulka, Patricia Kanngiesser, Daniel Haun, Jahnavi Sunderarajan, Magie Junker, Tongtong Meng, Wanting Sun, Zhen Zhang, Sandra Masaquiza, Monika Swastyastu, Desri Julita Taek, Arianna Abis, Disney Tjizao, Denis Chishala, Ljubica Petrović, Blanca Striegler, Janina Weyrowitz, Bernardo Arroyo-Garcia, Katja Liebal

School of Psychology

This paper examines the methodological and ethical challenges of conducting remoteresearch on child-animal relationships across thirty communities in seventeen countriesduring the COVID-19 pandemic. It critically assesses remote research as a mode ofcollaboration informed by decolonial aspirations, highlighting the complexities of navigatingtemporal and geographical distances, mitigating global inequalities, and addressing politicaland methodological tensions at the intersection of psychological anthropology and crosscultural developmental psychology. By engaging with these challenges, the paper fosterscritical dialogue on research ethics and methodologies between anthropology andpsychology, advancing a broader intellectual engagement toward translocal equity

[2025 Honorable Mention] The White Savior Trope In A “Post-Racial” Era, Gannon Camp

Ethnic Studies Research Paper Award

This paper explores how the media's promotion of the white savior trope, particularly following Obama's election, contributed to a false perception among Caucasians that significant racial issues had been resolved, despite evidence to the contrary.

Ascende Altius: Issue 5, Cynthia Haynes, Uofm Graduate School

Ascende Altius

Welcome to the UofM Graduate School newsletter Ascende Altius! This May 2025 edition documents key developments and achievements within the University of Memphis graduate community. It features a message from the Vice Provost and Dean, Dr. Deborah Tollefsen, outlining strategic initiatives including the awarding of Dissertation Completion Grants, the launch of a doctoral research grant competition, and enhancements to professional development programming.

This newsletter spotlights outstanding graduate students and alumni, celebrates faculty recognized for exemplary mentorship, and provides highlights from Spring Commencement, the Student Research Forum, and the Graduate Student Association Awards. Ascende Altius affirms the Graduate School’s ongoing …

Mutant P53 Gain Of Function: Why Many See It, Why Some Do Not, Guillermina Lozano, Carol Prives, Kanaga Sabapathy

Faculty, Staff and Student Publications

Mutations in the TP53 tumor-suppressor gene in human cancer are unique in that 60% to 70% are of the missense variety, resulting in a full-length protein that is often highly expressed in patients' tumors. These missense mutant proteins often exhibit pro-oncogenic activities (referred to as gain of function) in mouse models and human cell lines and correlate with poor cancer prognosis in some cases.

A Multimodal Therapeutic Strategy For Inflammatory Bowel Disease Using Microrna-146a Mimic Encapsulated In Lipid Nanoparticles., Kanika Suri, Vishnu Hosur, Rohit Panchakshari, Mansoor M Amiji

Faculty Research 2025

Dysregulated microRNAs (miRNAs) have significant potential as diagnostic tools for various chronic diseases; however, their therapeutic applications remain largely unexplored. Given their capacity to regulate multiple pathways, miRNAs are promising candidates for treating pleiotropic diseases, such as inflammatory bowel disease (IBD). In our study, we conducted a comprehensive review of the literature of miRNA-146 levels in the inflamed tissues of IBD patients and murine colitis models. Initially, we quantified the expression of miRNA-146a and miRNA-146b in the colons of mice using the dextran sodium sulfate (DSS)-inducedacute model of IBD. We selected miRNA-146a for further study due to its anti-inflammatory properties …

The Supernatural Shadow Of The Philosophic Fallacy: A Critical Examination Of John Dew-Ey’S Experience And Nature, Danica Jenck

Center for Dewey Studies Essay Award

In Experience and Nature, John Dewey asserts the existence of the philosophic fallacy. He describes the philosophic fallacy as understanding reality through abstractions rather than material causes that are situated in experience. However, Dewey’s writings on moral and religious development, particularly his criticisms of the supernatural, puts his philosophic fallacy into question. I argue that Dewey’s rejection of the supernatural is a mistake that limits his ability to clearly articulate his metaphysical project, demonstrating that Dewey’s rejection of supernatural experience commits the philosophic fallacy and is based in a Eurocentric tendency that can be escaped by challenging Eurocentric metaphysical …

Hyaluronan Network Remodeling By Zeb1 And Itih2 Enhances The Motility And Invasiveness Of Cancer Cells, Sieun Lee, Jihye Park, Seongran Cho, Eun Ju Kim, Seonyeong Oh, Younseo Lee, Sungsoo Park, Keunsoo Kang, Dong Hoon Shin, Song Yi Ko, Jonathan M Kurie, Young-Ho Ahn

Faculty, Staff and Student Publications

Hyaluronan (HA) in the extracellular matrix promotes epithelial-mesenchymal transition (EMT) and metastasis; however, the mechanism by which the HA network constructed by cancer cells regulates cancer progression and metastasis in the tumor microenvironment (TME) remains largely unknown. In this study, inter-α-trypsin inhibitor heavy chain 2 (ITIH2), an HA-binding protein, was confirmed to be secreted from mesenchymal-like lung cancer cells when cocultured with cancer-associated fibroblasts. ITIH2 expression is transcriptionally upregulated by the EMT-inducing transcription factor ZEB1, along with HA synthase 2 (HAS2), which positively correlates with ZEB1 expression. Depletion of ITIH2 and HAS2 reduced HA matrix formation and the migration and …

Bound: The Imaginative Surplus Of Contractual Intent, Elizabeth F. Emens

Faculty Scholarship

Contract law is generally understood in terms of enforcement. The legal definition of a contract is a promise that the state will enforce. Individuals are empowered by contract law to create legal arrangements that the state will step in and enforce. And yet most contracts never make it to court.

This Article inverts the conventional focus on enforcement through a study of extralegal contracts. These are formal written agreements that parties call contracts but are not intended for legal enforcement. Examples of these extralegal contracts include no-suicide contracts and contracts for sexual slavery.

Examining extralegal contracts offers multiple insights. First, …

Multiplicity As An Ai Governance Principle, Michal Shur-Ofry

Indiana Law Journal

As AI becomes increasingly embedded in our daily lives, this Article explores one of its critical, yet overlooked, societal implications: the propensity of large language models (LLMs) to generate mainstream, standardized content, potentially narrowing their users’ worldviews.

Taking a close look at the technological underpinnings of LLMs, the analysis suggests that—due to the combination of human judgments, training datasets, and inherent features of the underlying technological paradigm—LLMs’ outputs are likely to be geared toward the popular and to project to their users concentrated, mainstream worldviews, sidelining a broader spectrum of perspectives. This Article explores the asymmetrical power relations between LLMs …

Personal Information Sharing Behavior Using Social Media: A Bibliometric Analysis From 2007-2024, Ashraf Sharif, Khalid Mahmood, Shafiq Ur Rehman

Libraries

This study explores personal information sharing behavior publication patterns and trends on social media from 2007-2024 with an aim to highlight the annual growth of personal information sharing behavior (PISB) on social media platforms, key patterns in the PISB literature in terms of frequently cited authors, countries, institutions, sources, highly cited papers, collaboration and authorship patterns, thematic evolution, keyword and key factor analysis (such as countries, sources, and keywords). We used Scopus database for data extraction, and 1020 pertinent records were chosen. The data was evaluated with Microsoft Excel, Access, Biblioshiny and VOSviewer software. The United States of America is …

Solving Global Problems Requires Global Cohesion, Harvey Whitehouse, John, Lord Alderdice, Carlos Alvarado Quesada, Peter Gluckman, Hakima El Haité, Lukas Reinhardt

New England Journal of Public Policy

A growing body of evidence from evolutionary anthropology and social psychology suggests that group cohesion can be scaled up beyond the level of nations and even regional blocs and transnational religions to encompass humanity at large. This article brings together insights from globally renowned political leaders, activists, and academics by arguing that this scaling up is not only possible but necessary to address the most pressing collective action problems facing our planet today. Drawing on evidence from experiments, longitudinal studies, and multi-country surveys, along with extensive practical experience—from serving as a head of state to playing leading roles in climate …

Why Study Others?, Richard Feinberg

Pacific Studies

No abstract provided.

Exploring Who, Where, And When: A Mixed-Methods Analysis Of A New Study Abroad Program, Garrett Schoep, Elijah Duane Blake

Construction Management

Study abroad programs can have a significant impact on the lives of college students. These programs create opportunities for students to experience the world, while earning college credit. As Cal Poly is transitioning from the quarter system to the semester system, there is an increase demand for a new study abroad program that is tailored to students’ preferences. Understanding what students want from a study abroad program is extremely important. To better understand student preferences, a survey was created and distributed to Cal Poly students. The goal of the survey was to identify trends amongst students to get a better …

Exploring Advanced Theory Of Mind Development Across Sociocultural Contexts: An Evaluation Of The Strange Stories In Children From Mexico And Us–Mexico Border Communities, Katherine Rice Warnell, Amy A. Weimer, Rong Huang, Daniela Kuri

Psychological Science Faculty Publications

Recent research on advanced theory of mind (ToM) has questioned the extent to which existing ToM measures capture a single construct, particularly for groups understudied in developmental research. The present study examined the factor structure of one of the most commonly used advanced ToM measures, the Strange Stories task, in samples of low- and middle-income children in dual-language Spanish-English schools in US–Mexico border communities and in Mexico (N = 237 children, n = 108 male, n = 129 female, Mage = 10.05 years, SD = 1.15 years; 96.3% Hispanic/Latine). No clear factor structure emerged for the Strange Stories …

Theatricality Of The Ephemeral: Media Of Surplus And Spectatorship In Liang Dynasty (南朝梁, 502-557) Palace-Style Poetry And Hou Hsiao-Hsien’S A City Of Sadness (1989), Yingyi Wang

Comparative Literature M.A. Essays

This essay focuses on the mediation of spectatorship experience by “ephemeral media” in Liang Dynasty (南朝梁, 502-557) palace-style poetry and Hou Hsiao-hsien’s film A City of Sadness (1989). Drawing from Alexander Galloway’s “the interface effects” in new media studies, I investigate how the diegetic “ephemeral media” in these two texts, such as dust, candlelight, silence, and writing, function as opaque interfaces that complicate spectatorship. I examine spectatorship experience from the angle of ephemeral media by looking at how they direct spectators’ attention from the world of representations to processes of mediation. Transplanting Xiaofei Tian’s notion of the “surplus” in her …

Using Multiculturalism To Combat The Negative Creativity Effect Of Cultural Tightness: How It Is Done Matters, Jung Kiu Choi

Dissertations and Theses Collection (Open Access)

This study investigates the multifaceted influence of cultural tightness and multiculturalism on the global commercial success of pop music. Addressing an under-explored moderating effect of multicultural factors on creative output under tight culture, this research analyzes Billboard Global 200 and Spotify Top 50 chart data from 2013-2021. The empirical analysis reveals that cultural tightness negatively impacts pop song’s success. Conversely, multiculturalism, specifically through diverse languages and performance teams, generally enhances global success. A key finding is that while multicultural production teams do not directly correlate with success, they critically moderate the detrimental effects of cultural tightness, a buffering effect unique …

Beauty In The Feed: Exploring The Role Of Social Media In Women's Body Image And Emotional Satisfaction, Momina Hassan

University Honors Theses

Through a thematic analysis assessing four peer-reviewed studies, this thesis explores the relationship between social media (e.g., content, engagement factors) and how it impacts women's body image and emotional satisfaction. The studies varied in methodological approach and age demographics, but included only female participants. The research reviewed in this thesis calls attention to the harmful effects social media can have on women's health such as body dissatisfaction, anxiety, depression and disordered eating. The two main themes that emerged were appearance-based social comparison, and psychological impacts on mental health (e.g., anxiety, depression, disordered eating). Exposure to idealized images on social media …

Allergic Fungal Rhinosinusitis Diagnosis, Management, Associated Conditions, Pathophysiology, And Future Directions: Summary Of A Multidisciplinary Workshop, Lauren T Roland, Cecelia Damask, Amber U Luong, Antoine Azar, Charles S Ebert, Thomas Edwards, Katherine N Cahill, Do-Yeon Cho, David Corry, Tara L Croston, Alexandra F Freeman, Amin Javer, Paneez Khoury, Jean Kim, Michael Koval, Edward D Mccoul, James W Mims, Anju Peters, Jay F Piccirillo, Richard P Ramonell, Amali Samarasinghe, Robert P Schleimer, Prestina Smith-Davidson, Andrej Spec, Michael E Wechsler, Sarah K Wise, Joshua M Levy

The Brown Foundation: Institute of Molecular Medicine

Allergic fungal rhinosinusitis (AFRS) is a unique endotype of chronic rhinosinusitis with nasal polyps (CRSwNP). Despite high recurrence rates and often more severe presenting signs compared with other subtypes of CRSwNP, research dedicated to AFRS has been lacking. Diagnostic criteria are outdated, the mechanistic relationship of AFRS to other associated diseases is unclear, and the pathophysiology of disease and risk factors for recurrence have not been well studied. In December 2023, a multidisciplinary group of rhinologists, otolaryngologists, pulmonologists, allergists, immunologists, scientists, and infectious disease experts met at the National Institute of Health to discuss unmet needs for future AFRS research …

Allergic Fungal Rhinosinusitis Diagnosis, Management, Associated Conditions, Pathophysiology, And Future Directions: Summary Of A Multidisciplinary Workshop, Lauren T Roland, Cecelia Damask, Amber U Luong, Antoine Azar, Charles S Ebert, Thomas Edwards, Katherine N Cahill, Do-Yeon Cho, David Corry, Tara L Croston, Alexandra F Freeman, Amin Javer, Paneez Khoury, Jean Kim, Michael Koval, Edward D Mccoul, James W Mims, Anju Peters, Jay F Piccirillo, Richard P Ramonell, Amali Samarasinghe, Robert P Schleimer, Prestina Smith-Davidson, Andrej Spec, Michael E Wechsler, Sarah K Wise, Joshua M Levy

The Brown Foundation: Institute of Molecular Medicine

Allergic fungal rhinosinusitis (AFRS) is a unique endotype of chronic rhinosinusitis with nasal polyps (CRSwNP). Despite high recurrence rates and often more severe presenting signs compared with other subtypes of CRSwNP, research dedicated to AFRS has been lacking. Diagnostic criteria are outdated, the mechanistic relationship of AFRS to other associated diseases is unclear, and the pathophysiology of disease and risk factors for recurrence have not been well studied. In December 2023, a multidisciplinary group of rhinologists, otolaryngologists, pulmonologists, allergists, immunologists, scientists, and infectious disease experts met at the National Institute of Health to discuss unmet needs for future AFRS research …