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Gene Replacement-Alzheimer's Disease (Gr-Ad): Modeling The Genetics Of Human Dementias In Mice., Kellie Benzow, Kul Karanjeet, Adrian L Oblak, Gregory W. Carter, Michael Sasner, Michael D Koob

Faculty Research 2024

INTRODUCTION: Genetic studies conducted over the past four decades have provided us with a detailed catalog of genes that play critical roles in the etiology of Alzheimer's disease (AD) and related dementias (ADRDs). Despite this progress, as a field we have had only limited success in incorporating this rich complexity of human AD/ADRD genetics findings into our animal models of these diseases. Our primary goal for the gene replacement (GR)-AD project is to develop mouse lines that model the genetics of AD/ADRD as closely as possible.

METHODS: To do this, we are generating mouse lines in which the genes of …

2024 Little International Agricultural Exposition Catalog, Little International Agricultural Exposition South Dakota State University

Little International "Little I" Agricultural Exposition Catalogs

This is the catalog for the 101st Little International 'Little I' Agricultural  Exposition, held on April 5th & 6th, 2024.

Death, Dying, And Overcoming: A Nietzschean Reading Of Yukio Mishima’S Confessions Of A Mask, Chase Mikles

Munn Scholars Awards

Yukio Mishima’s first novel, Confessions of a Mask, was an instant success when it first published in 1949 and served as the beginning of Mishima’s rise to becoming one of, if not the most prominent postwar Japanese writers. However, because of the novel’s heavy nationalistic undertone tied with its very nontraditional and often lamenting perspective towards homosexuality, it has been largely overlooked by Western academia until recently. It presents a complex notion of queer identity, one that John Pistelli describes in his review as “[an] inapplicability of the word ‘queer,’ with all its contemporary political connotations, to a reactionary mid-century …

Preventative Conservation And Pest Management At The Wvu Natural History Museum, Amelia Blevins

Munn Scholars Awards

This paper identifies and proposes feasible solutions to potential threats jeopardizing the longevity of the WVU Natural History Museum and Research Collection with a primary emphasis on pest management. Additionally, this research serves as a starting point for future projects related to the improvement of the WVU Natural History Museum by students or staff. By addressing problems posed by agents of deterioration and providing potential solutions future contributors will be able to mitigate these concerns more efficiently.

April 1 Roundtable Update, Jeffrey M. Wice

Elections, Census & Redistricting Updates

No abstract provided.

Career Readiness: A Study Of Vietnamese University Students' Views On Post-Graduation Prospects, Tobias Amstutz

Independent Study Project (ISP) Collection

This study examines Vietnamese university students' perceptions and attitudes towards post-graduation job prospects, which could serve as an economic indicator. Utilizing survey data from over 200 students across institutions and disciplines, the research investigates how factors such as confidence in educational preparation, chosen field of study, and perceived job readiness relate to demographic characteristics and intentions to pursue the same academic path.

The most significant findings of the study reveal that English language confidence and major fields of study were influential factors in shaping students' perceptions and attitudes. Students with higher English confidence had statistically significantly higher levels of job …

“Njangi Never Dies”: The Social Impacts And Non-Financial Benefits Of Njangis In Batoufam And Yaoundé, Cameroon, Georgia Schaefer-Brown

Independent Study Project (ISP) Collection

Rotating Credits and Savings Associations (ROSCAs) are present in much of the developing world and are incredibly common in Cameroon. The financial impacts of ROSCAs have been researched extensively, but there has been less research on the social impacts and non-financial benefits. This research aims to fill this gap and add to the discussion of ROSCAs in Cameroon (called njangis), as well as demonstrate how njangis are social institutions. This project is in the specific context of njangis in Batoufam and Yaoundé, Cameroon. Interviews and observations informed the conclusion that there are extensive social impacts and non-financial benefits within the …

Avian Diversity And Abundance Among Agricultural Land, Forested Land, And Their Ecotone In Guadalupe, Cerro Punta, Chiriquí Province, Republic Of Panamá., Stella Rae Kinard

Independent Study Project (ISP) Collection

As the human population increases, finding the balance between modifying land use for resources and protecting areas to preserve species that are threatened by anthropogenic disturbance is an ever growing problem. Guadalupe is a town in the Western Highlands of Panamá that struggles in this balance as its primary income source is agriculture, but it is located on the border of two protected areas, Parque Nacional La Amistad and Parque Nacional Volcán Barú. By understanding the unique ways in which avifauna utilize distinct vegetative landscapes, recommendations can be made for management styles of farms in Guadalupe to implement practices that …

Interpretative Representation And Justice: The Effects Of Inadequate Translation On The Human Rights Of Migrants In The Justice System In Spain, Danielle E. Libby

Independent Study Project (ISP) Collection

Across the world there is an increasing human rights issue regarding the improper treatment of immigrants in the justice system. Fundamental human rights are protected by Spanish and European Union law, which includes the right to interpretative representation. Adequate interpretation and translation are recognized by many individuals in academia and law as crucial for adequate communication. The right to interpretative representation is essential to address the cross-linguistic and cross-cultural needs of migrants when entering a state that does not standardize their native tongue institutionally. When inadequacies appear with interpretation throughout the justice system, improper communication often occurs, causing issues for …

A Physiological Approach To Renal Clearance: From Premature Neonates To Adults, Nick Holford, Conor J. O'Hanlon, Karel Allegaert, Brian Anderson, Amilcar Falcão, Nicolas Simon, Yoke Lin Lo, Alison H. Thomson, Catherine M.T. Sherwin, Evelyne Jacqz-Aigrain, Carolina Llanos-Paez, Stefanie Hennig, Linas Mockus, Carl Kirkpatrick

Pediatrics Faculty Publications

Aims: We propose using glomerular filtration rate (GFR) as the physiological basis for distinguishing components of renal clearance. Methods: Gentamicin, amikacin and vancomycin are thought to be predominantly excreted by the kidneys. A mixed-effects joint model of the pharmacokinetics of these drugs was developed, with a wide dispersion of weight, age and serum creatinine. A dataset created from 18 sources resulted in 27,338 drug concentrations from 9,901 patients. Body size and composition, maturation and renal function were used to describe differences in drug clearance and volume of distribution. Results: This study demonstrates that GFR is a predictor of two distinct …

Moral Distress And Moral Injury In Military Healthcare Clinicians: A Scoping Review, Melissa A. Wilson, Amy Shay, J. Irene Harris, Nicole Faller, Timothy J. Usset, Angela Simmons

Nursing Faculty Publications

Introduction: Healthcare clinicians are often at risk of psychological distress due to the nature of their occupation. Military healthcare providers are at risk for additional psychological suffering related to unique moral and ethical situations encountered in military service. This scoping review identifies key characteristics of moral distress and moral injury and how these concepts relate to the military healthcare clinician who is both a care provider and service member.

Methods: A scoping review of moral distress and moral injury literature as relates to the military healthcare clinician was conducted on the basis of the Joanna Briggs Institute scoping review framework. …

Undergraduate And Graduate Course Descriptions, Spring 2024, Wright State University

Course Descriptions

Wright State University undergraduate and graduate course descriptions from Spring 2024

Mary Dean Lee Interviewed By Victoria Riva, Mary Dean Lee, Victoria Riva, Stephanie Opperman

Collecting the Past

Victoria Riva interviews Dr. Mary Dean Lee about growing up in Milledgeville Georgia.

Listen to the podcast version here:

YouTube

https://youtu.be/a-VjHJIZ05A?si=sPAJgc_EMHEuE0TV

Spotify

https://spotifyanchor-web.app.link/e/nElxuuiTwNb

Performance Outcomes In Introductory Statistics: R Vs. Spss Usage At A Community College, Venessa Singhroy Ph.D., Bianca Sosnovski

Publications and Research

This dataset corresponds to a study investigating the performance outcomes of students enrolled in two sections of an introductory statistics course at a community college in New York. The study, titled "Examining Differences in Performance Outcomes between Statistics Classes using High-coding vs. Low-coding Statistical Software Packages," explores the impact of utilizing different statistical software packages (R and SPSS) on student performance and motivation. The dataset comprises assessments administered to participants, including the Mathematics Motivation Questionnaire, Reading Comprehension Assessment, Algebra Assessment, Statistics Assessment, and Coding Assessment. Participants were divided into two sections: one utilizing R and the other utilizing SPSS for …

The Numeracy Intervention Project, Paige Smith

Master's Theses & Capstone Projects

This study focused on the Numeracy Intervention Project designed to detect gaps in student's mathematical learning. Research took place in the special education setting with one participant. Participants qualified by having an Individualized Education Plan with a goal specific to math instruction. The intervention took place over a two-week time period where the researcher and student met each day for thirty minutes. The Numeracy Intervention provided a scripted baseline assessment, hands on manipulatives, and several specific skill activities. Results from the baseline to post assessment showed no significant results. Study limitations and future research are included.

Preliminary Assessment Of Boat-Generated Wake Influence On The Ecological Structure Of A Seagrass Meadow, Noah Alexander Gorman

Harriet L Wilkes Honors College Theses 2020 - Present

Seagrass meadows are crucial ecosystems for countless marine fauna and flora. With the decline of these ecosystems globally, understanding the threats they face represents the first step in mitigating further destruction and establishing effective restoration efforts. The purpose of this thesis was to provide a preliminary assessment of the scale and intensity of boat-generated wakes on a severely reduced shallow-water seagrass meadow located in the southernmost portion of the Indian River Lagoon along a high-traffic recreational boating area. Wake intensity and seagrass structure (species composition, distribution, and abundance) was measured within Coral Cove Park, Jupiter, Florida. Results showed that the …

Doubly Almost Bipartite Leonard Pairs, Shuichi Masuda

Dissertations and Theses

In Linear algebra, the concept of Leonard pair (LP) was motivated by the theory of Q-polynomial distance-regular graphs. In this dissertation, we will first give a brief introduction to LPs and to two closely-related classes of objects: (i) bipartite Leonard pairs (BLPs) and (ii) almost bipartite Leonard pairs (ABLPs). Taking these as departure points, we will introduce a new class of object - doubly almost bipartite Leonard pairs (DABLPs). The primary aim of our work is to fully classify (up to isomorphism) this new family. In addition, since there is known to be a natural correspondence between Leonard pairs …

Supporting Identity Through Creative Writing: A Curriculum, Caleb Ehrenhaft , '25

Senior Theses, Projects, and Awards

No abstract provided.

Innovator, Scholar, Friend: Remembering Dmitry Karshtedt, Laura Pedraza-Fariña, David L. Schwartz

Northwestern Journal of Technology and Intellectual Property

No abstract provided.

Pedagogues And Prodigies: A Conductor’S Guide To Selected Works Of Sweelinck, L. Mozart, Schumann, Saint-Saëns, Thompson, And Larsen, Mason Rice

Research Papers

This research is presented to aid any educators, directors, and conductors who wish to program these composers and the selected pieces for their choral ensembles. The pieces chosen for analysis were presented in a Masters graduate recital on February 16, 2024, and were performed in the order of the paper, except that Reasons for Loving the Harmonica and The Best of Rooms were switched. Each chapter is laid out in four sections that focus on the selected piece: a brief biography of the composer, a musical analysis, rehearsal considerations, and a review of recordings. The selected pieces included in this …

Finding Identities: Identities In Video Games From A Gender, Race, And Identity Representation, Osayame Erinmwingbovo

ART 108: Introduction to Games Studies

In this paper I will bring light to the exploration of gender, race, and identity in video games. While also having a focus on how the representation crosses with social and cultural contexts. I will be researching different games from many different genres, which will show light to the way video games reflect and shape societal attitudes towards gender, race, and identity. When using close textual analysis and theoretical framework from topics that include critical race theory, media, and feminist theory. This research will help to seek to explore the nuances and complexities of representation in gaming which implicates video …

The Correlation Between Mutations Of Pms2 And Ovarian Cancer​, Elaine Vanterpool, Mayah Seal

Student Posters

No abstract provided.

Zeitgeist Of The 2010s And Impact On Fashion Trends, Sophie Scott Anderson

Senior Theses

The zeitgeist of the 2010s can be examined through shifts in technology, politics, economy, environment, religion, and entertainment. This research explores how fashion serves as both a mirror and a driver of societal change during this transformative decade. Trend diffusion itself evolved from the traditional theories of trickle-up and trickle-down because of the prominence of influencer culture, giving average consumers the platform to influence numerous like-minded consumers. Defining the 2010s zeitgeist requires an analysis of the significant patterns in the technological and sociocultural environment through as many sources as possible for a holistic approach. Sociologically, fashion has been accepted as …

The Increase Of Allergies In Developed Countries: A Comparison Of The Quality Of Life And Psychosocial Burden Of Individuals With Food Allergies In Switzerland And The United States Of America, Adrienne Ell

Independent Study Project (ISP) Collection

The Hygiene Hypothesis suggests that as societies become increasingly sterile and there is less exposure to microorganisms early in life; consequently, there is an increase in inflammatory autoimmune disorders and allergies due to a maladapted immune system to the new sterile environment. This hypothesis can offer a possible explanation for the observed increase in allergies, specifically food allergies, in developed countries. To explore the psychosocial burden of allergies and evaluate the quality of life this paper will explore the food allergen labeling policies for prepackaged foods, the regulation of allergen information for non-prepackaged foods, and the psychosocial burden food allergies …

Nutri-Score, Warning Signs, And Facts Up Front – In Theory And In Practice A Comparative Analysis Of The Effectiveness Of Front-Of-Package Labeling Systems, Muskaan Makkar

Independent Study Project (ISP) Collection

Suboptimal diets contribute significantly to poor health and chronic diseases, with excessive sodium intake and low consumption of whole grains, fruits, and vegetables being major risk factors. To address this global nutrition burden, various countries have implemented front-of-package labeling (FOPL) systems such as the Nutri-Score, Warning Signs, and Facts Up Front.

This paper aims to analyze the effectiveness of these systems – which vary in development, design, content, and implementation – in both theory and practice. The methodology involves a comparative analysis of three FOPL systems, assessing their theoretical effectiveness with international guidelines and practical effectiveness through expert interviews and …

Exploring The Medicalization Of Menstruation: Analyzing Menstrual Hygiene Initiatives By Igos, Non-Profits And National Government In Switzerland, Victoria Wright

Independent Study Project (ISP) Collection

Menstrual health serves as a critical indicator of reproductive health. It is pivotal in achieving various Sustainable Development Goals (SDGs) related to women's and girls' comfort, agency, participation, safety, well-being, and dignity (Loughnan et al., 2020). This research investigates the medicalization of menstruation in Switzerland through a mixed-methods approach examining the strategies and roles of key stakeholders such as the WHO, local government initiatives, and NGOs in shaping the landscape of menstrual medicalization.

The findings reveal that while medicalization has brought about progressive changes, including the introduction of menstrual leave policies, it has resulted in a complex regulatory landscape, increased …

Role-Playing And Rentierism: Rethinking Morocco’S Approach To Migration Diplomacy With The Eu, Mia Mcgrath

Independent Study Project (ISP) Collection

Morocco’s unique situation as a Mediterranean “gateway” between Africa and Europe makes the country a key strategic partner to the European Union. When it comes to migration diplomacy, however, cooperation between the two actors is hardly a given. This paper studies Morocco-EU migration diplomacy between 2000 and 2020. It provides an overview of the events and agreements that have shaped the relationship, with a focus on Morocco’s rationale. I argue that Morocco makes use of two tools to strengthen its negotiating position and narrow the gap in relative power – role-playing and rentierism. The former is an element of International …

Understanding The Evolutionary Conservation Of Ilp3 Gene Across Drosophila, Elias Ciudad, Cassandra Morales, Kendra Lancaster, Lori Boies

Posters - 2024

Drosophila melanogaster is a commonly used model organism in genetics and developmental biology. Research on the insulin signaling pathway in D. melanogaster provides evidence that it is similar to the human pathway and involved in metabolism, growth and lifespan regulation (5). The Genomic Education Partnership’s (GEP) Pathways Project is a network analysis that focuses on insulin signaling in the genus Drosophila through the annotation of genes (1). The approach of the project is to understand the evolutionary change in genes across species over time in biological pathways and look at the growth and metabolic homeostasis (2). Insulin, in Drosophila, is …

Mcnair Scholars Research Journal Xvi, St. Mary's University

McNair Scholars Research Journal

This is the sixteenth journal for the McNair Scholars Program at St. Mary's University

"Congratulations to the 2023 McNair Scholars on a wonderful summer of research… and congratulations to the McNair Program on a new, five year grant! It is amazing to realize that St. Mary’s was first funded for a Ronald E. McNair Post-baccalaureate Achievement grant in 2007 and that this marks our fourth consecutive successful funding. I say it is amazing because it seems like only yesterday we were receiving the exciting news this wonderful program would be available to help St. Mary’s students achieve their doctoral dreams. …

Library News April 2024, Research Medical Library

Library News 2024

• Acceptable Uses and Limitations of Generative AI in the Writing Process
• How to Overcome Writer's Block
• Journal Matching Tools
• Accessible Use of Color in Images
• How to Request a Consultation
• "Wait on" Or "Wait for"? Here's the Answer You've Been Waiting For!
• Need an Article? Use Interlibrary Loan